MLF1_HUMAN
Evidence for PS localization
Functions
Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI003005 | LIG_14-3-3_CanoR_1 | LIG | 31 | 36 | - |
| ELMI003005 | LIG_14-3-3_CanoR_1 | LIG | 31 | 36 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MLF1_HUMAN |
|---|---|---|---|---|
| GO:0031625 | ubiquitin protein ligase binding | 22.5000 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 22.5000 | 4 | no |
| GO:0003677 | DNA binding | 7.5000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MLF1_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 57.5000 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 57.5000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 52.5000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 52.5000 | 4 | no |
| GO:0010646 | regulation of cell communication | 42.5000 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 40.0000 | 4 | yes |
| GO:0010468 | regulation of gene expression | 40.0000 | 6 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 40.0000 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 40.0000 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 40.0000 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 40.0000 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 37.5000 | 4 | no |
| GO:0060341 | regulation of cellular localization | 37.5000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 35.0000 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 35.0000 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 35.0000 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 32.5000 | 7 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 32.5000 | 5 | yes |
| GO:0051252 | regulation of RNA metabolic process | 32.5000 | 5 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 32.5000 | 6 | yes |
| GO:0006996 | organelle organization | 32.5000 | 4 | no |
| GO:0031399 | regulation of protein modification process | 32.5000 | 6 | no |
| GO:0032880 | regulation of protein localization | 32.5000 | 5 | no |
| GO:0051049 | regulation of transport | 32.5000 | 4 | no |
| GO:0008104 | protein localization | 30.0000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.0000 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 25.0000 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0009894 | regulation of catabolic process | 22.5000 | 4 | no |
| GO:0030162 | regulation of proteolysis | 22.5000 | 6 | no |
| GO:0036211 | protein modification process | 22.5000 | 4 | no |
| GO:0043412 | macromolecule modification | 22.5000 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 22.5000 | 5 | no |
| GO:0071310 | cellular response to organic substance | 22.5000 | 4 | no |
| GO:0051726 | regulation of cell cycle | 17.5000 | 4 | yes |
| GO:0010564 | regulation of cell cycle process | 12.5000 | 5 | yes |
| GO:0090304 | nucleic acid metabolic process | 10.0000 | 4 | yes |
| GO:0002244 | hematopoietic progenitor cell differentiation | 7.5000 | 4 | yes |
| GO:0009059 | macromolecule biosynthetic process | 7.5000 | 4 | yes |
| GO:0016070 | RNA metabolic process | 7.5000 | 5 | yes |
| GO:1901796 | regulation of signal transduction by p53 class mediator | 7.5000 | 6 | yes |
| GO:1901987 | regulation of cell cycle phase transition | 7.5000 | 6 | yes |
| GO:0002318 | myeloid progenitor cell differentiation | 5.0000 | 5 | yes |
| GO:0006351 | DNA-templated transcription | 5.0000 | 6 | yes |
| GO:0032774 | RNA biosynthetic process | 5.0000 | 5 | yes |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 5.0000 | 4 | yes |
| GO:0141187 | nucleic acid biosynthetic process | 5.0000 | 5 | yes |
| GO:1901362 | organic cyclic compound biosynthetic process | 5.0000 | 4 | yes |
| GO:1902806 | regulation of cell cycle G1/S phase transition | 5.0000 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 1433Z_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DYL2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EIF3G_HUMAN | [view interactions] | Low throughput | no | yes |
| CYBP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NUCL_HUMAN | [view interactions] | Low throughput | no | yes |
| NRBP_HUMAN | [view interactions] | Low throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CENPU_HUMAN | [view interactions] | Low throughput | no | no |
| CSN3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| COP1_HUMAN | [view interactions] | Low throughput | no | no |
| 1433S_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| THSD4_HUMAN | [view interactions] | High throughput | no | no |
| NDC80_HUMAN | [view interactions] | High throughput | no | no |
| E41L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BUB1_HUMAN | [view interactions] | High throughput | no | no |
| ZWINT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KAPCG_HUMAN | [view interactions] | High throughput | no | no |
| KAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRCA2_HUMAN | [view interactions] | High throughput | no | no |
| KIF11_HUMAN | [view interactions] | High throughput | no | yes |
| TROP_HUMAN | [view interactions] | High throughput | no | no |
| ERC6L_HUMAN | [view interactions] | High throughput | no | yes |
| WAC2A_HUMAN | [view interactions] | High throughput | no | yes |
| CRBG3_HUMAN | [view interactions] | High throughput | no | no |
| PMF1_HUMAN | [view interactions] | High throughput | no | no |
| FA83H_HUMAN | [view interactions] | High throughput | no | yes |
| SPC24_HUMAN | [view interactions] | High throughput | no | no |
| ATG2B_HUMAN | [view interactions] | High throughput | no | no |
| DSN1_HUMAN | [view interactions] | High throughput | no | yes |
| AKA11_HUMAN | [view interactions] | High throughput | no | yes |
| DNJB8_HUMAN | [view interactions] | High throughput | no | no |
| PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| MAGAB_HUMAN | [view interactions] | High throughput | no | no |
| GRIK5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MLF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| IRS4_HUMAN | [view interactions] | High throughput | no | no |
| GNB5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TET3_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD3_HUMAN | [view interactions] | High throughput | no | yes |
| ZBED4_HUMAN | [view interactions] | High throughput | no | yes |
| REC8_HUMAN | [view interactions] | High throughput | no | yes |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MOS_HUMAN | [view interactions] | High throughput | no | no |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GNAZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERCC3_HUMAN | [view interactions] | High throughput | no | yes |
| DNJB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNA15_HUMAN | [view interactions] | High throughput | no | yes |
| MCM5_HUMAN | [view interactions] | High throughput | no | no |
| MCM7_HUMAN | [view interactions] | High throughput | no | no |
| CACP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLCN2_HUMAN | [view interactions] | High throughput | no | yes |
| MLF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUDC3_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKBPL_HUMAN | [view interactions] | High throughput | no | yes |
| NAL12_HUMAN | [view interactions] | High throughput | no | yes |
| GBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAD51_HUMAN | [view interactions] | High throughput | no | yes |
| NR1H3_HUMAN | [view interactions] | High throughput | no | yes |
| SKP2_HUMAN | [view interactions] | High throughput | no | yes |
| SIM2_HUMAN | [view interactions] | High throughput | no | yes |
| RCN2_HUMAN | [view interactions] | High throughput | no | yes |
| SETB1_HUMAN | [view interactions] | High throughput | no | yes |
| RCN1_HUMAN | [view interactions] | High throughput | no | yes |
| STK11_HUMAN | [view interactions] | High throughput | no | yes |
| KLH38_HUMAN | [view interactions] | High throughput | no | no |
| EIPR1_HUMAN | [view interactions] | High throughput | no | yes |
| TFDP3_HUMAN | [view interactions] | High throughput | no | no |
| GET4_HUMAN | [view interactions] | High throughput | no | yes |
| GTD2A_HUMAN | [view interactions] | High throughput | no | no |
| SIR6_HUMAN | [view interactions] | High throughput | no | yes |
| HUS1B_HUMAN | [view interactions] | High throughput | no | no |
| SMRD2_HUMAN | [view interactions] | High throughput | no | no |
| TRI43_HUMAN | [view interactions] | High throughput | no | no |
| ERF1_HUMAN | [view interactions] | High throughput | no | yes |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| TBB1_HUMAN | [view interactions] | High throughput | no | yes |
| TLR7_HUMAN | [view interactions] | High throughput | no | no |
| E2AK4_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| Z3H7B_HUMAN | [view interactions] | High throughput | no | no |
| UBP18_HUMAN | [view interactions] | High throughput | no | yes |
| CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI17_HUMAN | [view interactions] | High throughput | no | yes |
| DJC13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMT1_HUMAN | [view interactions] | High throughput | no | yes |
| TBCE_HUMAN | [view interactions] | High throughput | no | no |
| EDRF1_HUMAN | [view interactions] | High throughput | no | no |
| FYB2_HUMAN | [view interactions] | High throughput | no | no |
| I2BP1_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF2_HUMAN | [view interactions] | High throughput | no | yes |
| TANK_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| MEOX2_HUMAN | [view interactions] | High throughput | no | no |
| MAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNRG_HUMAN | [view interactions] | High throughput | no | yes |
| KAPCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HTR5B_HUMAN | [view interactions] | High throughput | no | yes |
| CK5P2_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK1_HUMAN | [view interactions] | High throughput | no | yes |
| KNL1_HUMAN | [view interactions] | High throughput | no | no |
| HAUS6_HUMAN | [view interactions] | High throughput | no | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| ALMS1_HUMAN | [view interactions] | High throughput | no | no |
| RGPD5_HUMAN | [view interactions] | High throughput | no | no |
| HAUS8_HUMAN | [view interactions] | High throughput | no | yes |
| HERC1_HUMAN | [view interactions] | High throughput | no | no |
| GRDN_HUMAN | [view interactions] | High throughput | no | no |
| APOB_HUMAN | [view interactions] | High throughput | no | no |
| P73_HUMAN | [view interactions] | High throughput | no | no |
| TRBP2_HUMAN | [view interactions] | High throughput | no | yes |
| HYPK_HUMAN | [view interactions] | High throughput | no | no |
| DUS16_HUMAN | [view interactions] | High throughput | no | yes |
| CE295_HUMAN | [view interactions] | High throughput | no | yes |
| AASD1_HUMAN | [view interactions] | High throughput | no | yes |
| KI20B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PROZ_HUMAN | [view interactions] | High throughput | no | no |
| PLEC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WNK1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RBG1L_HUMAN | [view interactions] | High throughput | no | yes |
| CDC16_HUMAN | [view interactions] | High throughput | no | yes |
| TSHR_HUMAN | [view interactions] | High throughput | no | no |
| BAG4_HUMAN | [view interactions] | High throughput | no | yes |
| RELL2_HUMAN | [view interactions] | High throughput | no | no |
| UT2_HUMAN | [view interactions] | High throughput | no | no |
| NRSN1_HUMAN | [view interactions] | High throughput | no | yes |
| BORC8_HUMAN | [view interactions] | High throughput | no | yes |
| PRLD2_HUMAN | [view interactions] | High throughput | no | no |
| TNR1B_HUMAN | [view interactions] | High throughput | no | no |
| KNG1_HUMAN | [view interactions] | High throughput | no | no |
| SCAR3_HUMAN | [view interactions] | High throughput | no | yes |
| MAGA9_HUMAN | [view interactions] | High throughput | no | no |
| KI2L1_HUMAN | [view interactions] | High throughput | no | no |
| KI2L4_HUMAN | [view interactions] | High throughput | no | no |
| MRAP2_HUMAN | [view interactions] | High throughput | no | no |
| ANM6_HUMAN | [view interactions] | High throughput | no | yes |
| OTUD3_HUMAN | [view interactions] | High throughput | no | yes |
| KCNE3_HUMAN | [view interactions] | High throughput | no | yes |
| TMM74_HUMAN | [view interactions] | High throughput | no | no |
| SOLH1_HUMAN | [view interactions] | High throughput | no | no |
| DNJB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP6R3_HUMAN | [view interactions] | High throughput | no | yes |
| NPAS1_HUMAN | [view interactions] | High throughput | no | no |
| AN13A_HUMAN | [view interactions] | High throughput | no | yes |
| CF141_HUMAN | [view interactions] | High throughput | no | no |
| ACACB_HUMAN | [view interactions] | High throughput | no | no |
| BAG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BLTP2_HUMAN | [view interactions] | High throughput | no | yes |
| IFT56_HUMAN | [view interactions] | High throughput | no | no |
| GPC5B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSPB8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TDRD3_HUMAN | [view interactions] | High throughput | no | yes |
| DBLOH_HUMAN | [view interactions] | High throughput | no | no |
| S2512_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EYA4_HUMAN | [view interactions] | High throughput | no | yes |