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CACP_HUMAN

Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio. Also plays a crucial role in the transport of fatty acids for beta-oxidation (PubMed, PubMed). Responsible for the synthesis of short- and branched-chain acylcarnitines (PubMed). Active towards some branched-chain amino acid oxidation pathway (BCAAO) intermediates (PubMed). Trans-2-enoyl-CoAs and 2-methylacyl-CoAs are poor substrates (PubMed). [View more on UniProt]

Interacting region for partners were not defined.

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in CACP_HUMAN
GO:0003723 RNA binding 21.0526 4 no
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 15.7895 4 yes
GO:0008374 O-acyltransferase activity 10.5263 5 yes
GO:0008458 carnitine O-octanoyltransferase activity 10.5263 7 yes
GO:0016406 carnitine O-acyltransferase activity 10.5263 6 yes
GO:0016407 acetyltransferase activity 10.5263 5 yes
GO:0016414 O-octanoyltransferase activity 10.5263 6 yes
GO:0016415 octanoyltransferase activity 10.5263 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CACP_HUMAN
GO:0019752 carboxylic acid metabolic process 36.8421 5 yes
GO:0043436 oxoacid metabolic process 36.8421 4 yes
GO:0031323 regulation of cellular metabolic process 36.8421 4 no
GO:0006631 fatty acid metabolic process 31.5789 4 yes
GO:0006635 fatty acid beta-oxidation 31.5789 6 yes
GO:0009062 fatty acid catabolic process 31.5789 5 yes
GO:0016042 lipid catabolic process 31.5789 4 yes
GO:0016054 organic acid catabolic process 31.5789 4 yes
GO:0019395 fatty acid oxidation 31.5789 5 yes
GO:0030258 lipid modification 31.5789 4 yes
GO:0032787 monocarboxylic acid metabolic process 31.5789 6 yes
GO:0034440 lipid oxidation 31.5789 5 yes
GO:0044242 cellular lipid catabolic process 31.5789 4 yes
GO:0046395 carboxylic acid catabolic process 31.5789 5 yes
GO:0072329 monocarboxylic acid catabolic process 31.5789 6 yes
GO:0009889 regulation of biosynthetic process 31.5789 4 no
GO:0010556 regulation of macromolecule biosynthetic process 31.5789 5 no
GO:0031326 regulation of cellular biosynthetic process 31.5789 5 no
GO:0060255 regulation of macromolecule metabolic process 31.5789 4 no
GO:0010468 regulation of gene expression 26.3158 6 no
GO:0022607 cellular component assembly 26.3158 4 no
GO:0048523 negative regulation of cellular process 26.3158 4 no
GO:0080090 regulation of primary metabolic process 21.0526 4 no
GO:0071310 cellular response to organic substance 21.0526 4 no
GO:0043933 protein-containing complex organization 21.0526 4 no
GO:0006163 purine nucleotide metabolic process 21.0526 5 no
GO:0006753 nucleoside phosphate metabolic process 21.0526 4 no
GO:0006796 phosphate-containing compound metabolic process 21.0526 4 no
GO:0009117 nucleotide metabolic process 21.0526 5 no
GO:0009150 purine ribonucleotide metabolic process 21.0526 6 no
GO:0009259 ribonucleotide metabolic process 21.0526 5 no
GO:0019693 ribose phosphate metabolic process 21.0526 4 no
GO:0072521 purine-containing compound metabolic process 21.0526 4 no
GO:0006996 organelle organization 21.0526 4 no
GO:0009893 positive regulation of metabolic process 21.0526 4 no
GO:0051128 regulation of cellular component organization 21.0526 4 no
GO:0071702 organic substance transport 21.0526 4 no
GO:0006577 amino-acid betaine metabolic process 10.5263 4 yes
GO:0009437 carnitine metabolic process 10.5263 5 yes
GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase 10.5263 7 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
H2B1H_HUMAN [view interactions] High throughput no yes
HSPB2_HUMAN [view interactions] High throughput no yes
KCNQ1_HUMAN [view interactions] High throughput no yes
CAV3_HUMAN [view interactions] High throughput no no
MLF1_HUMAN [view entry] [view interactions] High throughput yes yes
MLF2_HUMAN [view entry] [view interactions] High throughput yes yes
NUDC3_HUMAN [view interactions] High throughput no yes
CYBP_HUMAN [view entry] [view interactions] High throughput yes yes
PEX5_HUMAN [view interactions] High throughput no yes
RGS3_HUMAN [view interactions] High throughput no no
FBXL4_HUMAN [view interactions] High throughput no yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
HINT2_HUMAN [view interactions] High throughput no yes
PFD5_HUMAN [view interactions] High throughput no yes
SPAT2_HUMAN [view interactions] High throughput no yes
SMAD4_HUMAN [view interactions] High throughput no yes
PTSS1_HUMAN [view interactions] High throughput no no
UCRI_HUMAN [view entry] [view interactions] High throughput yes yes
COX41_HUMAN [view entry] [view interactions] High throughput yes yes
MTU1_HUMAN [view interactions] High throughput no no
THIM_HUMAN [view interactions] High throughput no yes
FA12_HUMAN [view interactions] High throughput no no
KBL_HUMAN [view interactions] High throughput no yes
DIC_HUMAN [view interactions] High throughput no yes
CBR4_HUMAN [view interactions] High throughput no yes
RSLAB_HUMAN [view interactions] High throughput no no
SYYM_HUMAN [view interactions] High throughput no no
RT02_HUMAN [view interactions] High throughput no no
ACSM5_HUMAN [view interactions] High throughput no yes
MRM2_HUMAN [view interactions] High throughput no yes
NDUS7_HUMAN [view entry] [view interactions] High throughput yes no
MAP12_HUMAN [view interactions] High throughput no no
MYL10_HUMAN [view interactions] High throughput no no
NPSR1_HUMAN [view interactions] High throughput no no
NUD16_HUMAN [view interactions] High throughput no yes
NPS3A_HUMAN [view interactions] High throughput no yes
PLD5_HUMAN [view interactions] High throughput no no
ETKMT_HUMAN [view interactions] High throughput no yes
NIPS2_HUMAN [view interactions] High throughput no yes
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
ACOX1_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
MCAT_HUMAN [view interactions] High throughput no yes
CPT2_HUMAN [view entry] [view interactions] High throughput yes yes
ECHM_HUMAN [view interactions] High throughput no yes
ELAV2_HUMAN [view interactions] High throughput no yes
SCO1_HUMAN [view interactions] High throughput no yes
AASD1_HUMAN [view interactions] High throughput no yes
ACADL_HUMAN [view interactions] High throughput no no
ACADS_HUMAN [view interactions] High throughput no yes
ACADV_HUMAN [view interactions] High throughput no yes
ECH1_HUMAN [view interactions] High throughput no yes
ECI2_HUMAN [view entry] [view interactions] High throughput yes yes
DHB4_HUMAN [view entry] [view interactions] High throughput yes yes
HSDL2_HUMAN [view entry] [view interactions] High throughput yes yes
ACOT8_HUMAN [view entry] [view interactions] High throughput yes yes
DR4L2_HUMAN [view interactions] High throughput no no
DHRS4_HUMAN [view entry] [view interactions] High throughput yes no
ECHP_HUMAN [view interactions] High throughput no no
ECHB_HUMAN [view entry] [view interactions] High throughput yes yes
PEX14_HUMAN [view interactions] High throughput no yes
CHIN_HUMAN [view interactions] High throughput no no
NQO2_HUMAN [view interactions] High throughput no yes
SPTB2_HUMAN [view entry] [view interactions] High throughput yes yes
CLPP_HUMAN [view interactions] High throughput no yes
CISY_HUMAN [view entry] [view interactions] High throughput yes yes