CACP_HUMAN
Evidence for PS localization
Functions
Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio. Also plays a crucial role in the transport of fatty acids for beta-oxidation (PubMed, PubMed). Responsible for the synthesis of short- and branched-chain acylcarnitines (PubMed). Active towards some branched-chain amino acid oxidation pathway (BCAAO) intermediates (PubMed). Trans-2-enoyl-CoAs and 2-methylacyl-CoAs are poor substrates (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CACP_HUMAN |
|---|---|---|---|---|
| GO:0016747 | acyltransferase activity, transferring groups other than amino-acyl groups | 17.3913 | 4 | yes |
| GO:0008374 | O-acyltransferase activity | 13.0435 | 5 | yes |
| GO:0008458 | carnitine O-octanoyltransferase activity | 8.6957 | 7 | yes |
| GO:0016406 | carnitine O-acyltransferase activity | 8.6957 | 6 | yes |
| GO:0016407 | acetyltransferase activity | 8.6957 | 5 | yes |
| GO:0016413 | O-acetyltransferase activity | 8.6957 | 6 | yes |
| GO:0016414 | O-octanoyltransferase activity | 8.6957 | 6 | yes |
| GO:0016415 | octanoyltransferase activity | 8.6957 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CACP_HUMAN |
|---|---|---|---|---|
| GO:0019752 | carboxylic acid metabolic process | 39.1304 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 39.1304 | 4 | yes |
| GO:0006631 | fatty acid metabolic process | 34.7826 | 4 | yes |
| GO:0032787 | monocarboxylic acid metabolic process | 34.7826 | 6 | yes |
| GO:0006635 | fatty acid beta-oxidation | 30.4348 | 6 | yes |
| GO:0009062 | fatty acid catabolic process | 30.4348 | 5 | yes |
| GO:0016042 | lipid catabolic process | 30.4348 | 4 | yes |
| GO:0016054 | organic acid catabolic process | 30.4348 | 4 | yes |
| GO:0019395 | fatty acid oxidation | 30.4348 | 5 | yes |
| GO:0030258 | lipid modification | 30.4348 | 4 | yes |
| GO:0034440 | lipid oxidation | 30.4348 | 5 | yes |
| GO:0044242 | cellular lipid catabolic process | 30.4348 | 4 | yes |
| GO:0046395 | carboxylic acid catabolic process | 30.4348 | 5 | yes |
| GO:0072329 | monocarboxylic acid catabolic process | 30.4348 | 6 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 30.4348 | 4 | no |
| GO:0010468 | regulation of gene expression | 26.0870 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 26.0870 | 4 | no |
| GO:0022607 | cellular component assembly | 26.0870 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 26.0870 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 21.7391 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 21.7391 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 21.7391 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 21.7391 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 21.7391 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 21.7391 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 21.7391 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 21.7391 | 4 | no |
| GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase | 13.0435 | 7 | yes |
| GO:0006577 | amino-acid betaine metabolic process | 8.6957 | 4 | yes |
| GO:0009437 | carnitine metabolic process | 8.6957 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| H2B1H_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB2_HUMAN | [view interactions] | High throughput | no | yes |
| KCNQ1_HUMAN | [view interactions] | High throughput | no | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| MLF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MLF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUDC3_HUMAN | [view interactions] | High throughput | no | yes |
| CYBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEX5_HUMAN | [view interactions] | High throughput | no | yes |
| RGS3_HUMAN | [view interactions] | High throughput | no | no |
| FBXL4_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HINT2_HUMAN | [view interactions] | High throughput | no | yes |
| PFD5_HUMAN | [view interactions] | High throughput | no | yes |
| SPAT2_HUMAN | [view interactions] | High throughput | no | yes |
| SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
| PTSS1_HUMAN | [view interactions] | High throughput | no | no |
| UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTU1_HUMAN | [view interactions] | High throughput | no | no |
| THIM_HUMAN | [view interactions] | High throughput | no | yes |
| FA12_HUMAN | [view interactions] | High throughput | no | no |
| KBL_HUMAN | [view interactions] | High throughput | no | yes |
| DIC_HUMAN | [view interactions] | High throughput | no | yes |
| CBR4_HUMAN | [view interactions] | High throughput | no | yes |
| RSLAB_HUMAN | [view interactions] | High throughput | no | no |
| SYYM_HUMAN | [view interactions] | High throughput | no | no |
| RT02_HUMAN | [view interactions] | High throughput | no | no |
| ACSM5_HUMAN | [view interactions] | High throughput | no | yes |
| MRM2_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MAP12_HUMAN | [view interactions] | High throughput | no | no |
| MYL10_HUMAN | [view interactions] | High throughput | no | no |
| NPSR1_HUMAN | [view interactions] | High throughput | no | no |
| NUD16_HUMAN | [view interactions] | High throughput | no | yes |
| NPS3A_HUMAN | [view interactions] | High throughput | no | yes |
| PLD5_HUMAN | [view interactions] | High throughput | no | no |
| ETKMT_HUMAN | [view interactions] | High throughput | no | yes |
| NIPS2_HUMAN | [view interactions] | High throughput | no | yes |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACOX1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCAT_HUMAN | [view interactions] | High throughput | no | yes |
| CPT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV2_HUMAN | [view interactions] | High throughput | no | yes |
| SCO1_HUMAN | [view interactions] | High throughput | no | yes |
| AASD1_HUMAN | [view interactions] | High throughput | no | yes |
| ACADL_HUMAN | [view interactions] | High throughput | no | no |
| ACADS_HUMAN | [view interactions] | High throughput | no | yes |
| ACADV_HUMAN | [view interactions] | High throughput | no | yes |
| ECH1_HUMAN | [view interactions] | High throughput | no | yes |
| ECI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSDL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACOT8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHRS4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ECHP_HUMAN | [view interactions] | High throughput | no | no |
| ECHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEX14_HUMAN | [view interactions] | High throughput | no | yes |
| SPTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HAOX2_HUMAN | [view interactions] | Computational | no | no |
| PAOX_HUMAN | [view interactions] | Computational | no | no |
| LONP2_HUMAN | [view interactions] | Computational | no | yes |
| HACL1_HUMAN | [view interactions] | Computational | no | no |
| IDHC_HUMAN | [view interactions] | Computational | no | no |
| HMGCL_HUMAN | [view interactions] | Computational | no | yes |
| GNPAT_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GSTK1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| BAAT_HUMAN | [view interactions] | Computational | no | no |
| HYES_HUMAN | [view interactions] | Computational | no | no |
| OCTC_HUMAN | [view interactions] | Computational | no | yes |
| ACOT2_HUMAN | [view interactions] | Computational | no | yes |
| SOX_HUMAN | [view interactions] | Computational | no | no |
| OXDD_HUMAN | [view interactions] | Computational | no | yes |
| ACOT4_HUMAN | [view interactions] | Computational | no | yes |
| NOS2_HUMAN | [view interactions] | Computational | no | yes |
| AMACR_HUMAN | [view interactions] | Computational | no | yes |
| ACOX3_HUMAN | [view interactions] | Computational | no | yes |
| NUD19_HUMAN | [view interactions] | Computational | no | no |
| S27A2_HUMAN | [view interactions] | Computational | no | no |
| NUDT7_HUMAN | [view interactions] | Computational | no | yes |
| DECR2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| MPV17_HUMAN | [view interactions] | Computational | no | no |
| PECR_HUMAN | [view interactions] | Computational | no | yes |
| DCMC_HUMAN | [view interactions] | Computational | no | no |
| SCP2_HUMAN | [view interactions] | Computational | no | no |
| SPYA_HUMAN | [view interactions] | Computational | no | no |
| CATA_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| IDE_HUMAN | [view interactions] | Computational | no | yes |
| OXDA_HUMAN | [view interactions] | Computational | no | no |
| HAOX1_HUMAN | [view interactions] | Computational | no | no |
| ACOX2_HUMAN | [view interactions] | Computational | no | yes |
| TYSD1_HUMAN | [view interactions] | Computational | no | yes |