Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ACOT8_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

(Microbial infection) May mediate Nef-induced down-regulation of CD4 cell-surface expression (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ACOT8_HUMAN
GO:0000166 nucleotide binding 29.4118 4 no
GO:0017076 purine nucleotide binding 29.4118 5 no
GO:0003723 RNA binding 23.5294 4 no
GO:0019900 kinase binding 23.5294 4 no
GO:0019901 protein kinase binding 23.5294 5 no
GO:0030554 adenyl nucleotide binding 23.5294 6 no
GO:0032555 purine ribonucleotide binding 23.5294 4 no
GO:0035639 purine ribonucleoside triphosphate binding 23.5294 4 no
GO:0043168 anion binding 23.5294 4 no
GO:0043169 cation binding 23.5294 4 no
GO:0046872 metal ion binding 23.5294 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in ACOT8_HUMAN
GO:0048523 negative regulation of cellular process 47.0588 4 yes
GO:0031323 regulation of cellular metabolic process 41.1765 4 yes
GO:0031326 regulation of cellular biosynthetic process 41.1765 5 yes
GO:0060255 regulation of macromolecule metabolic process 41.1765 4 yes
GO:0080090 regulation of primary metabolic process 41.1765 4 yes
GO:0009889 regulation of biosynthetic process 41.1765 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 41.1765 5 yes
GO:0031324 negative regulation of cellular metabolic process 35.2941 5 yes
GO:0051246 regulation of protein metabolic process 35.2941 5 yes
GO:0009966 regulation of signal transduction 35.2941 4 no
GO:0010468 regulation of gene expression 35.2941 6 no
GO:0010646 regulation of cell communication 35.2941 4 no
GO:0048522 positive regulation of cellular process 35.2941 4 no
GO:1902531 regulation of intracellular signal transduction 35.2941 5 no
GO:0009890 negative regulation of biosynthetic process 35.2941 5 yes
GO:0009892 negative regulation of metabolic process 35.2941 4 yes
GO:0019752 carboxylic acid metabolic process 29.4118 5 yes
GO:0031327 negative regulation of cellular biosynthetic process 29.4118 6 yes
GO:0032787 monocarboxylic acid metabolic process 29.4118 6 yes
GO:0043436 oxoacid metabolic process 29.4118 4 yes
GO:0009893 positive regulation of metabolic process 29.4118 4 no
GO:0043933 protein-containing complex organization 29.4118 4 no
GO:0006796 phosphate-containing compound metabolic process 29.4118 4 yes
GO:0006996 organelle organization 29.4118 4 yes
GO:0008202 steroid metabolic process 29.4118 4 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 29.4118 6 yes
GO:0010605 negative regulation of macromolecule metabolic process 29.4118 5 yes
GO:1901362 organic cyclic compound biosynthetic process 23.5294 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 23.5294 5 no
GO:0051128 regulation of cellular component organization 23.5294 4 no
GO:0009968 negative regulation of signal transduction 23.5294 5 no
GO:0010648 negative regulation of cell communication 23.5294 5 no
GO:0023057 negative regulation of signaling 23.5294 4 no
GO:0042981 regulation of apoptotic process 23.5294 5 no
GO:0043067 regulation of programmed cell death 23.5294 4 no
GO:0048585 negative regulation of response to stimulus 23.5294 4 no
GO:1902532 negative regulation of intracellular signal transduction 23.5294 6 no
GO:0006355 regulation of DNA-templated transcription 23.5294 7 no
GO:0006357 regulation of transcription by RNA polymerase II 23.5294 8 no
GO:0009059 macromolecule biosynthetic process 23.5294 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 23.5294 5 no
GO:0048584 positive regulation of response to stimulus 23.5294 4 no
GO:0051252 regulation of RNA metabolic process 23.5294 5 no
GO:2001141 regulation of RNA biosynthetic process 23.5294 6 no
GO:0006915 apoptotic process 23.5294 4 no
GO:0006631 fatty acid metabolic process 23.5294 4 yes
GO:0019693 ribose phosphate metabolic process 17.6471 4 yes
GO:0030258 lipid modification 17.6471 4 yes
GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase 17.6471 7 yes
GO:0033865 nucleoside bisphosphate metabolic process 17.6471 5 yes
GO:0033875 ribonucleoside bisphosphate metabolic process 17.6471 6 yes
GO:0034032 purine nucleoside bisphosphate metabolic process 17.6471 5 yes
GO:0034440 lipid oxidation 17.6471 5 yes
GO:0044242 cellular lipid catabolic process 17.6471 4 yes
GO:0046395 carboxylic acid catabolic process 17.6471 5 yes
GO:0051248 negative regulation of protein metabolic process 17.6471 6 yes
GO:0072329 monocarboxylic acid catabolic process 17.6471 6 yes
GO:0072521 purine-containing compound metabolic process 17.6471 4 yes
GO:0001676 long-chain fatty acid metabolic process 17.6471 5 yes
GO:0006163 purine nucleotide metabolic process 17.6471 5 yes
GO:0006635 fatty acid beta-oxidation 17.6471 6 yes
GO:0006753 nucleoside phosphate metabolic process 17.6471 4 yes
GO:0008610 lipid biosynthetic process 17.6471 4 yes
GO:0009062 fatty acid catabolic process 17.6471 5 yes
GO:0009117 nucleotide metabolic process 17.6471 5 yes
GO:0009150 purine ribonucleotide metabolic process 17.6471 6 yes
GO:0009259 ribonucleotide metabolic process 17.6471 5 yes
GO:0016042 lipid catabolic process 17.6471 4 yes
GO:0016054 organic acid catabolic process 17.6471 4 yes
GO:0019395 fatty acid oxidation 17.6471 5 yes
GO:0033559 unsaturated fatty acid metabolic process 11.7647 5 yes
GO:0036109 alpha-linolenic acid metabolic process 11.7647 4 yes
GO:0008206 bile acid metabolic process 11.7647 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ISG15_HUMAN [view interactions] High throughput no no
RING2_HUMAN [view interactions] High throughput no yes
PML_HUMAN [view interactions] High throughput no yes
MTMRE_HUMAN [view entry] [view interactions] High throughput yes yes
TP4A1_HUMAN [view interactions] High throughput no no
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA4_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
BRD1_HUMAN [view interactions] High throughput no yes
BRD8_HUMAN [view interactions] High throughput no yes
SP100_HUMAN [view interactions] High throughput no no
TAF1_HUMAN [view interactions] High throughput no yes
TRI66_HUMAN [view interactions] High throughput no no
INS_HUMAN [view interactions] High throughput no no
NMRL1_HUMAN [view interactions] High throughput no yes
DX39A_HUMAN [view interactions] High throughput no yes
CDC26_HUMAN [view interactions] High throughput no yes
COA7_HUMAN [view interactions] High throughput no yes
VSTM1_HUMAN [view interactions] High throughput no no
SNX21_HUMAN [view interactions] High throughput no yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
BRCA1_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
VIGLN_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
OTUL_HUMAN [view interactions] High throughput no yes
CL16A_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
OTUD4_HUMAN [view interactions] High throughput no yes
FBX7_HUMAN [view interactions] High throughput no yes
ACSL1_HUMAN [view interactions] High throughput no no
ACSL6_HUMAN [view entry] [view interactions] High throughput yes yes
ELAV2_HUMAN [view interactions] High throughput no yes
PEX7_HUMAN [view interactions] High throughput no yes
TRAP1_HUMAN [view entry] [view interactions] High throughput yes yes
NEDD8_HUMAN [view entry] [view interactions] High throughput yes yes
NMT1_HUMAN [view interactions] High throughput no yes
THIK_HUMAN [view entry] [view interactions] High throughput yes yes
CACP_HUMAN [view entry] [view interactions] High throughput yes yes
HACL1_HUMAN [view interactions] High throughput no no
PTGR3_HUMAN [view interactions] High throughput no yes
RBM47_HUMAN [view interactions] High throughput no yes
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
ADAS_HUMAN [view interactions] High throughput no yes
AMPN_HUMAN [view interactions] High throughput no no
TM11B_HUMAN [view interactions] High throughput no no
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
NEDD1_HUMAN [view interactions] High throughput no yes
IGHA1_HUMAN [view entry] [view interactions] High throughput yes yes
KLH23_HUMAN [view interactions] High throughput no no
PTN3_HUMAN [view interactions] High throughput no yes
ODPA_HUMAN [view entry] [view interactions] High throughput yes yes
MK04_HUMAN [view interactions] High throughput no no
MAST1_HUMAN [view interactions] High throughput no yes
HSC20_HUMAN [view interactions] High throughput no yes
PEX5_HUMAN [view interactions] High throughput no yes
REL_HUMAN [view interactions] High throughput no yes
P4HA3_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
CATA_HUMAN [view entry] [view interactions] High throughput yes no
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
PRD16_HUMAN [view interactions] High throughput no no