Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

IGHA1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed, PubMed). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed, PubMed). Ig alpha is the major immunoglobulin class in body secretions (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in IGHA1_HUMAN
GO:0019900 kinase binding 27.2727 4 no
GO:0044389 ubiquitin-like protein ligase binding 27.2727 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in IGHA1_HUMAN
GO:0048522 positive regulation of cellular process 72.7273 4 yes
GO:0031323 regulation of cellular metabolic process 63.6364 4 no
GO:0051171 regulation of nitrogen compound metabolic process 63.6364 4 no
GO:0080090 regulation of primary metabolic process 63.6364 4 no
GO:0009893 positive regulation of metabolic process 63.6364 4 yes
GO:0048523 negative regulation of cellular process 54.5455 4 no
GO:0051246 regulation of protein metabolic process 54.5455 5 no
GO:0060255 regulation of macromolecule metabolic process 54.5455 4 no
GO:0010646 regulation of cell communication 54.5455 4 no
GO:0009889 regulation of biosynthetic process 45.4545 4 no
GO:0009892 negative regulation of metabolic process 45.4545 4 no
GO:0010605 negative regulation of macromolecule metabolic process 45.4545 5 no
GO:0031324 negative regulation of cellular metabolic process 45.4545 5 no
GO:0031326 regulation of cellular biosynthetic process 45.4545 5 no
GO:0009894 regulation of catabolic process 45.4545 4 no
GO:0010604 positive regulation of macromolecule metabolic process 45.4545 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 45.4545 5 no
GO:0009966 regulation of signal transduction 45.4545 4 no
GO:0048584 positive regulation of response to stimulus 45.4545 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 36.3636 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 36.3636 5 no
GO:0051248 negative regulation of protein metabolic process 36.3636 6 no
GO:0010468 regulation of gene expression 36.3636 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 36.3636 5 no
GO:0022607 cellular component assembly 36.3636 4 no
GO:0031325 positive regulation of cellular metabolic process 36.3636 5 no
GO:0042176 regulation of protein catabolic process 36.3636 5 no
GO:0001932 regulation of protein phosphorylation 36.3636 7 no
GO:0019220 regulation of phosphate metabolic process 36.3636 6 no
GO:0031399 regulation of protein modification process 36.3636 6 no
GO:0042127 regulation of cell population proliferation 36.3636 4 no
GO:0042325 regulation of phosphorylation 36.3636 7 no
GO:0051128 regulation of cellular component organization 36.3636 4 no
GO:0051130 positive regulation of cellular component organization 36.3636 5 no
GO:0051174 regulation of phosphorus metabolic process 36.3636 5 no
GO:0051247 positive regulation of protein metabolic process 36.3636 6 no
GO:1902531 regulation of intracellular signal transduction 36.3636 5 no
GO:0002684 positive regulation of immune system process 36.3636 4 yes
GO:0050776 regulation of immune response 36.3636 4 yes
GO:0050778 positive regulation of immune response 36.3636 5 yes
GO:0050867 positive regulation of cell activation 27.2727 5 yes
GO:0051249 regulation of lymphocyte activation 27.2727 5 yes
GO:0051251 positive regulation of lymphocyte activation 27.2727 6 yes
GO:0061024 membrane organization 27.2727 4 yes
GO:0006996 organelle organization 27.2727 4 no
GO:0006355 regulation of DNA-templated transcription 27.2727 6 no
GO:0009891 positive regulation of biosynthetic process 27.2727 5 no
GO:0030334 regulation of cell migration 27.2727 5 no
GO:0031328 positive regulation of cellular biosynthetic process 27.2727 6 no
GO:0032880 regulation of protein localization 27.2727 5 no
GO:0048732 gland development 27.2727 4 no
GO:0051049 regulation of transport 27.2727 4 no
GO:0051252 regulation of RNA metabolic process 27.2727 5 no
GO:0060341 regulation of cellular localization 27.2727 4 no
GO:1903506 regulation of nucleic acid-templated transcription 27.2727 7 no
GO:1903829 positive regulation of protein localization 27.2727 5 no
GO:2000145 regulation of cell motility 27.2727 4 no
GO:2001141 regulation of RNA biosynthetic process 27.2727 6 no
GO:0007167 enzyme-linked receptor protein signaling pathway 27.2727 4 no
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 27.2727 5 no
GO:0009967 positive regulation of signal transduction 27.2727 5 no
GO:0010639 negative regulation of organelle organization 27.2727 6 no
GO:0010647 positive regulation of cell communication 27.2727 5 no
GO:0010941 regulation of cell death 27.2727 4 no
GO:0023056 positive regulation of signaling 27.2727 4 no
GO:0031344 regulation of cell projection organization 27.2727 5 no
GO:0031346 positive regulation of cell projection organization 27.2727 6 no
GO:0031401 positive regulation of protein modification process 27.2727 7 no
GO:0033043 regulation of organelle organization 27.2727 5 no
GO:0042981 regulation of apoptotic process 27.2727 6 no
GO:0043067 regulation of programmed cell death 27.2727 5 no
GO:0044087 regulation of cellular component biogenesis 27.2727 4 no
GO:0044089 positive regulation of cellular component biogenesis 27.2727 5 no
GO:0051129 negative regulation of cellular component organization 27.2727 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 27.2727 6 no
GO:1902533 positive regulation of intracellular signal transduction 27.2727 6 no
GO:1902903 regulation of supramolecular fiber organization 27.2727 5 no
GO:1902904 negative regulation of supramolecular fiber organization 27.2727 6 no
GO:0009968 negative regulation of signal transduction 27.2727 5 no
GO:0010648 negative regulation of cell communication 27.2727 5 no
GO:0023057 negative regulation of signaling 27.2727 4 no
GO:0043549 regulation of kinase activity 27.2727 5 no
GO:0043933 protein-containing complex organization 27.2727 4 no
GO:0045595 regulation of cell differentiation 27.2727 4 no
GO:0045859 regulation of protein kinase activity 27.2727 6 no
GO:0048585 negative regulation of response to stimulus 27.2727 4 no
GO:0051240 positive regulation of multicellular organismal process 27.2727 4 no
GO:0051338 regulation of transferase activity 27.2727 4 no
GO:0065003 protein-containing complex assembly 27.2727 5 no
GO:0002429 immune response-activating cell surface receptor signaling pathway 27.2727 4 yes
GO:0002694 regulation of leukocyte activation 27.2727 4 yes
GO:0002696 positive regulation of leukocyte activation 27.2727 5 yes
GO:0002768 immune response-regulating cell surface receptor signaling pathway 27.2727 4 yes
GO:0006958 complement activation, classical pathway 27.2727 4 yes
GO:0050851 antigen receptor-mediated signaling pathway 27.2727 5 yes
GO:0050865 regulation of cell activation 27.2727 4 yes
GO:0050871 positive regulation of B cell activation 18.1818 7 yes
GO:0060249 anatomical structure homeostasis 18.1818 4 yes
GO:0060263 regulation of respiratory burst 18.1818 4 yes
GO:0060267 positive regulation of respiratory burst 18.1818 5 yes
GO:0097205 renal filtration 18.1818 4 yes
GO:0099024 plasma membrane invagination 18.1818 6 yes
GO:0001894 tissue homeostasis 18.1818 5 yes
GO:0001895 retina homeostasis 18.1818 6 yes
GO:0003094 glomerular filtration 18.1818 5 yes
GO:0006911 phagocytosis, engulfment 18.1818 7 yes
GO:0010324 membrane invagination 18.1818 5 yes
GO:0019730 antimicrobial humoral response 18.1818 4 yes
GO:0019731 antibacterial humoral response 18.1818 5 yes
GO:0042742 defense response to bacterium 18.1818 4 yes
GO:0050853 B cell receptor signaling pathway 18.1818 6 yes
GO:0050864 regulation of B cell activation 18.1818 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ALBU_HUMAN [view interactions] Low throughput no no
FCAR_HUMAN [view interactions] Low throughput no no
IGHA1_HUMAN [view entry] [view interactions] Low throughput yes yes
PIGR_HUMAN [view interactions] Low throughput no no
IGJ_HUMAN [view interactions] Low throughput no no
CLCA1_HUMAN [view interactions] Low throughput no no
HAVR1_HUMAN [view interactions] Low throughput no yes
CK5P3_HUMAN [view entry] [view interactions] High throughput yes yes
CDKA1_HUMAN [view interactions] High throughput no yes
TTHY_HUMAN [view interactions] High throughput no no
TRY3_HUMAN [view interactions] High throughput no no
TRFE_HUMAN [view interactions] High throughput no no
TIAM1_HUMAN [view entry] [view interactions] High throughput yes yes
TBC19_HUMAN [view interactions] High throughput no yes
CKAP2_HUMAN [view interactions] High throughput no yes
KVD40_HUMAN [view interactions] High throughput no no
FINC_HUMAN [view interactions] High throughput no yes
HEP2_HUMAN [view interactions] High throughput no no
UNC79_HUMAN [view interactions] High throughput no no
LV147_HUMAN [view interactions] High throughput no no
K2C1_HUMAN [view interactions] High throughput no no
TGM4_HUMAN [view interactions] High throughput no no
FIBA_HUMAN [view interactions] High throughput no no
SPEF2_HUMAN [view interactions] High throughput no no
K1C9_HUMAN [view interactions] High throughput no no
PARD3_HUMAN [view interactions] High throughput no yes
CTR9_HUMAN [view interactions] High throughput no yes
CA2D2_HUMAN [view entry] [view interactions] High throughput yes yes
CATL1_HUMAN [view interactions] High throughput no yes
K1C10_HUMAN [view interactions] High throughput no no
APOA1_HUMAN [view interactions] High throughput no no
GDF10_HUMAN [view interactions] High throughput no yes
GTPB3_HUMAN [view interactions] High throughput no yes
PNMA1_HUMAN [view interactions] High throughput no yes
QTRT2_HUMAN [view interactions] High throughput no yes
K1C14_HUMAN [view interactions] High throughput no no
APOC1_HUMAN [view interactions] High throughput no no
SRTD3_HUMAN [view interactions] High throughput no no
PLMN_HUMAN [view interactions] High throughput no no
IGLC1_HUMAN [view interactions] High throughput no no
MTREX_HUMAN [view interactions] High throughput no yes
CLUS_HUMAN [view entry] [view interactions] High throughput yes yes
CHM4C_HUMAN [view interactions] High throughput no yes
KV320_HUMAN [view interactions] High throughput no no
JUN_HUMAN [view interactions] High throughput no yes
F13B_HUMAN [view interactions] High throughput no no
LRRK2_HUMAN [view interactions] High throughput no yes
STK4_HUMAN [view interactions] High throughput no yes
NFKB1_HUMAN [view interactions] High throughput no yes
FHI1A_HUMAN [view interactions] High throughput no yes
FADD_HUMAN [view interactions] High throughput no yes
TANK_HUMAN [view interactions] High throughput no yes
SLX4_HUMAN [view interactions] High throughput no yes
ATG5_HUMAN [view interactions] High throughput no no
I5P1_HUMAN [view interactions] High throughput no yes
FRMD1_HUMAN [view interactions] High throughput no no
DDX31_HUMAN [view interactions] High throughput no no
NPB_HUMAN [view interactions] High throughput no no
QCR8_HUMAN [view interactions] High throughput no yes
RUXF_HUMAN [view interactions] High throughput no no
HBM_HUMAN [view interactions] High throughput no no
EAPP_HUMAN [view interactions] High throughput no yes
ALDH2_HUMAN [view entry] [view interactions] High throughput yes no
KI2S2_HUMAN [view interactions] High throughput no no
ICE2_HUMAN [view interactions] High throughput no no
EFTS_HUMAN [view interactions] High throughput no no
ZN491_HUMAN [view interactions] High throughput no no
PKHG6_HUMAN [view interactions] High throughput no yes
TF2B_HUMAN [view interactions] High throughput no yes
GKN1_HUMAN [view interactions] High throughput no no
PCKGM_HUMAN [view interactions] High throughput no no
ITPI2_HUMAN [view interactions] High throughput no yes
KT3K_HUMAN [view interactions] High throughput no yes
PRAP1_HUMAN [view interactions] High throughput no no
ACOT8_HUMAN [view entry] [view interactions] High throughput yes yes
PK3CA_HUMAN [view entry] [view interactions] High throughput yes yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
APC_HUMAN [view entry] [view interactions] High throughput yes no
CAV1_HUMAN [view interactions] High throughput no no