IGHA1_HUMAN
Evidence for PS localization
Functions
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed, PubMed). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed, PubMed). Ig alpha is the major immunoglobulin class in body secretions (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in IGHA1_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 33.3333 | 4 | no |
| GO:0019901 | protein kinase binding | 33.3333 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 25.0000 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in IGHA1_HUMAN |
|---|---|---|---|---|
| GO:0080090 | regulation of primary metabolic process | 66.6667 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 58.3333 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 58.3333 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 58.3333 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 58.3333 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 58.3333 | 4 | no |
| GO:0010646 | regulation of cell communication | 58.3333 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 50.0000 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 50.0000 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 50.0000 | 4 | no |
| GO:0009894 | regulation of catabolic process | 50.0000 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 50.0000 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 50.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 50.0000 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 50.0000 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
| GO:0050776 | regulation of immune response | 41.6667 | 4 | yes |
| GO:0010468 | regulation of gene expression | 41.6667 | 6 | no |
| GO:0022607 | cellular component assembly | 41.6667 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 41.6667 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 41.6667 | 5 | no |
| GO:0043933 | protein-containing complex organization | 41.6667 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 41.6667 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 41.6667 | 6 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 41.6667 | 6 | no |
| GO:0032880 | regulation of protein localization | 41.6667 | 5 | no |
| GO:0060341 | regulation of cellular localization | 41.6667 | 4 | no |
| GO:0009966 | regulation of signal transduction | 41.6667 | 4 | no |
| GO:0002684 | positive regulation of immune system process | 33.3333 | 4 | yes |
| GO:0050778 | positive regulation of immune response | 33.3333 | 5 | yes |
| GO:0006996 | organelle organization | 33.3333 | 4 | no |
| GO:0031399 | regulation of protein modification process | 33.3333 | 6 | no |
| GO:0033043 | regulation of organelle organization | 33.3333 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 33.3333 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 33.3333 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 33.3333 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 33.3333 | 4 | no |
| GO:0051049 | regulation of transport | 33.3333 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0042176 | regulation of protein catabolic process | 33.3333 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 33.3333 | 4 | no |
| GO:1903829 | positive regulation of protein localization | 33.3333 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 33.3333 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 33.3333 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 33.3333 | 5 | no |
| GO:0002429 | immune response-activating cell surface receptor signaling pathway | 25.0000 | 4 | yes |
| GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 25.0000 | 4 | yes |
| GO:0006958 | complement activation, classical pathway | 25.0000 | 4 | yes |
| GO:0050851 | antigen receptor-mediated signaling pathway | 25.0000 | 5 | yes |
| GO:0140546 | defense response to symbiont | 25.0000 | 4 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 25.0000 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 25.0000 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 25.0000 | 6 | no |
| GO:0031400 | negative regulation of protein modification process | 25.0000 | 7 | no |
| GO:0043066 | negative regulation of apoptotic process | 25.0000 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 25.0000 | 5 | no |
| GO:0043244 | regulation of protein-containing complex disassembly | 25.0000 | 5 | no |
| GO:0051050 | positive regulation of transport | 25.0000 | 4 | no |
| GO:0060491 | regulation of cell projection assembly | 25.0000 | 5 | no |
| GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 25.0000 | 6 | no |
| GO:0006355 | regulation of DNA-templated transcription | 25.0000 | 7 | no |
| GO:0008104 | protein localization | 25.0000 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 25.0000 | 5 | no |
| GO:0010243 | response to organonitrogen compound | 25.0000 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.0000 | 6 | no |
| GO:0014070 | response to organic cyclic compound | 25.0000 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
| GO:0030334 | regulation of cell migration | 25.0000 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.0000 | 6 | no |
| GO:0034330 | cell junction organization | 25.0000 | 4 | no |
| GO:0048638 | regulation of developmental growth | 25.0000 | 4 | no |
| GO:0048732 | gland development | 25.0000 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 25.0000 | 5 | no |
| GO:2000145 | regulation of cell motility | 25.0000 | 4 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 25.0000 | 6 | no |
| GO:0001932 | regulation of protein phosphorylation | 25.0000 | 7 | no |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 25.0000 | 4 | no |
| GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway | 25.0000 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 25.0000 | 5 | no |
| GO:0010639 | negative regulation of organelle organization | 25.0000 | 6 | no |
| GO:0010648 | negative regulation of cell communication | 25.0000 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 25.0000 | 6 | no |
| GO:0023057 | negative regulation of signaling | 25.0000 | 4 | no |
| GO:0031346 | positive regulation of cell projection organization | 25.0000 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 25.0000 | 7 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 25.0000 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 25.0000 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0065003 | protein-containing complex assembly | 25.0000 | 5 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 25.0000 | 5 | no |
| GO:1902904 | negative regulation of supramolecular fiber organization | 25.0000 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 25.0000 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 25.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 25.0000 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 25.0000 | 6 | no |
| GO:0003094 | glomerular filtration | 16.6667 | 5 | yes |
| GO:0019730 | antimicrobial humoral response | 16.6667 | 4 | yes |
| GO:0019731 | antibacterial humoral response | 16.6667 | 5 | yes |
| GO:0042742 | defense response to bacterium | 16.6667 | 4 | yes |
| GO:0050853 | B cell receptor signaling pathway | 16.6667 | 6 | yes |
| GO:0060263 | regulation of respiratory burst | 16.6667 | 4 | yes |
| GO:0060267 | positive regulation of respiratory burst | 16.6667 | 5 | yes |
| GO:0097205 | renal filtration | 16.6667 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ALBU_HUMAN | [view interactions] | Low throughput | no | no |
| FCAR_HUMAN | [view interactions] | Low throughput | no | no |
| IGHA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PIGR_HUMAN | [view interactions] | Low throughput | no | no |
| IGJ_HUMAN | [view interactions] | Low throughput | no | no |
| CLCA1_HUMAN | [view interactions] | Low throughput | no | no |
| HAVR1_HUMAN | [view interactions] | Low throughput | no | yes |
| CA2D2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTR9_HUMAN | [view interactions] | High throughput | no | yes |
| PARD3_HUMAN | [view interactions] | High throughput | no | yes |
| K1C9_HUMAN | [view interactions] | High throughput | no | no |
| SPEF2_HUMAN | [view interactions] | High throughput | no | no |
| FIBA_HUMAN | [view interactions] | High throughput | no | no |
| TGM4_HUMAN | [view interactions] | High throughput | no | no |
| K2C1_HUMAN | [view interactions] | High throughput | no | no |
| LV147_HUMAN | [view interactions] | High throughput | no | no |
| UNC79_HUMAN | [view interactions] | High throughput | no | no |
| HEP2_HUMAN | [view interactions] | High throughput | no | no |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| KVD40_HUMAN | [view interactions] | High throughput | no | no |
| CKAP2_HUMAN | [view interactions] | High throughput | no | yes |
| TBC19_HUMAN | [view interactions] | High throughput | no | yes |
| TIAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRFE_HUMAN | [view interactions] | High throughput | no | no |
| TRY3_HUMAN | [view interactions] | High throughput | no | no |
| TTHY_HUMAN | [view interactions] | High throughput | no | no |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| F13B_HUMAN | [view interactions] | High throughput | no | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| STK4_HUMAN | [view interactions] | High throughput | no | yes |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| FHI1A_HUMAN | [view interactions] | High throughput | no | yes |
| FADD_HUMAN | [view interactions] | High throughput | no | yes |
| TANK_HUMAN | [view interactions] | High throughput | no | yes |
| SLX4_HUMAN | [view interactions] | High throughput | no | yes |
| ATG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| I5P1_HUMAN | [view interactions] | High throughput | no | yes |
| FRMD1_HUMAN | [view interactions] | High throughput | no | no |
| DDX31_HUMAN | [view interactions] | High throughput | no | no |
| NPB_HUMAN | [view interactions] | High throughput | no | no |
| QCR8_HUMAN | [view interactions] | High throughput | no | yes |
| RUXF_HUMAN | [view interactions] | High throughput | no | no |
| HBM_HUMAN | [view interactions] | High throughput | no | no |
| EAPP_HUMAN | [view interactions] | High throughput | no | yes |
| ALDH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KI2S2_HUMAN | [view interactions] | High throughput | no | no |
| ICE2_HUMAN | [view interactions] | High throughput | no | no |
| ZN491_HUMAN | [view interactions] | High throughput | no | no |
| PKHG6_HUMAN | [view interactions] | High throughput | no | yes |
| TF2B_HUMAN | [view interactions] | High throughput | no | yes |
| EFTS_HUMAN | [view interactions] | High throughput | no | no |
| GKN1_HUMAN | [view interactions] | High throughput | no | no |
| ITPI2_HUMAN | [view interactions] | High throughput | no | yes |
| PCKGM_HUMAN | [view interactions] | High throughput | no | no |
| ACOT8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRAP1_HUMAN | [view interactions] | High throughput | no | no |
| KT3K_HUMAN | [view interactions] | High throughput | no | yes |
| PK3CA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| APC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| CK5P3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDKA1_HUMAN | [view interactions] | High throughput | no | yes |
| KV320_HUMAN | [view interactions] | High throughput | no | no |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| CLUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTREX_HUMAN | [view interactions] | High throughput | no | yes |
| IGLC1_HUMAN | [view interactions] | High throughput | no | no |
| PLMN_HUMAN | [view interactions] | High throughput | no | no |
| SRTD3_HUMAN | [view interactions] | High throughput | no | no |
| APOC1_HUMAN | [view interactions] | High throughput | no | no |
| K1C14_HUMAN | [view interactions] | High throughput | no | no |
| QTRT2_HUMAN | [view interactions] | High throughput | no | yes |
| PNMA1_HUMAN | [view interactions] | High throughput | no | yes |
| GTPB3_HUMAN | [view interactions] | High throughput | no | yes |
| GDF10_HUMAN | [view interactions] | High throughput | no | yes |
| APOA1_HUMAN | [view interactions] | High throughput | no | no |
| K1C10_HUMAN | [view interactions] | High throughput | no | no |
| CATL1_HUMAN | [view interactions] | High throughput | no | yes |