Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

APC_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
171 Ser Ile Familialadenomatouspolyposis1(FAP1) -
414 Arg Cys Familialadenomatouspolyposis1(FAP1) -
784 Ser Thr Familialadenomatouspolyposis1(FAP1) -
817 Gly Cys Gastriccancer(GASC) -
880 Ile Thr Gastriccancer(GASC) -
911 Glu Gly Familialadenomatouspolyposis1(FAP1) -
942 Asn Asp Gastriccancer(GASC) -
1120 Gly Glu Gastriccancer(GASC) -
1171 Arg His Gastriccancer(GASC) -
1176 Pro Leu Familialadenomatouspolyposis1(FAP1) -
1197 Phe Ser Gastriccancer(GASC) -
1259 Ile Thr Gastriccancer(GASC) -
1312 Gly Glu Gastriccancer(GASC) -
1313 Thr Ala Familialadenomatouspolyposis1(FAP1) -
1326 Val Ala Gastriccancer(GASC) -
1348 Arg Trp Familialadenomatouspolyposis1(FAP1) -
2839 Leu Phe Familialadenomatouspolyposis1(FAP1) -
722 Ser Gly Familialadenomatouspolyposis1(FAP1) -
1184 Ala Pro Familialadenomatouspolyposis1(FAP1) -
1296 Ala Val Medulloblastoma(MDB) -
1472 Val Ile Medulloblastoma(MDB) -
1495 Ser Gly Medulloblastoma(MDB) -

Linear motifs

ELM instance Name Type Start End Partner
ELMI001285 LIG_SxIP_EBH_1 LIG 2801 2811 -
ELMI003247 MOD_CDK_SPxK_1 MOD 1357 1363 -
ELMI003815 MOD_CK1_1 MOD 1507 1513 -
ELMI000913 TRG_NES_CRM1_1 TRG 67 78 -
ELMI000914 TRG_NES_CRM1_1 TRG 163 176 -
ELMI001380 TRG_NLS_MonoCore_2 TRG 2048 2053 -
ELMI001379 TRG_NLS_MonoExtC_3 TRG 2048 2053 -
ELMI001378 TRG_NLS_MonoExtN_4 TRG 2048 2054 -
ELMI002398 TRG_NLS_MonoExtN_4 TRG 2049 2054 -
ELMI001285 LIG_SxIP_EBH_1 LIG 2801 2811 -
ELMI003247 MOD_CDK_SPxK_1 MOD 1357 1363 -
ELMI003815 MOD_CK1_1 MOD 1507 1513 -
ELMI000913 TRG_NES_CRM1_1 TRG 67 78 -
ELMI000914 TRG_NES_CRM1_1 TRG 163 176 -
ELMI001380 TRG_NLS_MonoCore_2 TRG 2048 2053 -
ELMI001379 TRG_NLS_MonoExtC_3 TRG 2048 2053 -
ELMI001378 TRG_NLS_MonoExtN_4 TRG 2048 2054 -
ELMI002398 TRG_NLS_MonoExtN_4 TRG 2049 2054 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in APC_HUMAN
GO:0043168 anion binding 26.0870 4 no
GO:0019900 kinase binding 24.3478 4 yes
GO:0000166 nucleotide binding 24.3478 4 no
GO:0017076 purine nucleotide binding 24.3478 5 no
GO:0045296 cadherin binding 22.6087 4 no
GO:0032555 purine ribonucleotide binding 22.6087 4 no
GO:0035639 purine ribonucleoside triphosphate binding 22.6087 4 no
GO:0019901 protein kinase binding 21.7391 5 yes
GO:0003723 RNA binding 21.7391 4 no
GO:0030554 adenyl nucleotide binding 20.8696 6 no
GO:0015631 tubulin binding 18.2609 4 yes
GO:0008017 microtubule binding 15.6522 5 yes
GO:0044389 ubiquitin-like protein ligase binding 10.4348 4 yes
GO:0031625 ubiquitin protein ligase binding 9.5652 5 yes
GO:0019887 protein kinase regulator activity 7.8261 4 yes
GO:0051010 microtubule plus-end binding 6.0870 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in APC_HUMAN
GO:0048522 positive regulation of cellular process 60.8696 4 yes
GO:0060255 regulation of macromolecule metabolic process 57.3913 4 yes
GO:0048523 negative regulation of cellular process 54.7826 4 yes
GO:0080090 regulation of primary metabolic process 51.3043 4 yes
GO:0006996 organelle organization 50.4348 4 no
GO:0010646 regulation of cell communication 50.4348 4 yes
GO:0031323 regulation of cellular metabolic process 50.4348 4 yes
GO:0008104 protein localization 47.8261 4 no
GO:0022607 cellular component assembly 46.0870 4 yes
GO:0051128 regulation of cellular component organization 45.2174 4 yes
GO:0009966 regulation of signal transduction 43.4783 4 yes
GO:0009893 positive regulation of metabolic process 41.7391 4 yes
GO:0009889 regulation of biosynthetic process 40.8696 4 no
GO:0010556 regulation of macromolecule biosynthetic process 40.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 40.0000 5 no
GO:0010604 positive regulation of macromolecule metabolic process 40.0000 5 yes
GO:0010468 regulation of gene expression 39.1304 6 no
GO:0051246 regulation of protein metabolic process 37.3913 5 yes
GO:0007010 cytoskeleton organization 33.9130 5 no
GO:0031325 positive regulation of cellular metabolic process 31.3043 5 no
GO:0051049 regulation of transport 28.6957 4 no
GO:0009892 negative regulation of metabolic process 28.6957 4 yes
GO:0051247 positive regulation of protein metabolic process 27.8261 6 yes
GO:0023056 positive regulation of signaling 26.9565 4 no
GO:0010605 negative regulation of macromolecule metabolic process 26.9565 5 yes
GO:0031324 negative regulation of cellular metabolic process 26.9565 5 yes
GO:0010647 positive regulation of cell communication 26.0870 5 no
GO:0030030 cell projection organization 26.0870 4 no
GO:1902531 regulation of intracellular signal transduction 26.0870 5 no
GO:0044087 regulation of cellular component biogenesis 26.0870 4 yes
GO:0060341 regulation of cellular localization 25.2174 4 yes
GO:0071702 organic substance transport 25.2174 4 no
GO:0071705 nitrogen compound transport 25.2174 4 no
GO:0048584 positive regulation of response to stimulus 25.2174 4 no
GO:0031399 regulation of protein modification process 25.2174 6 yes
GO:0033043 regulation of organelle organization 25.2174 5 yes
GO:0042127 regulation of cell population proliferation 25.2174 4 yes
GO:0051130 positive regulation of cellular component organization 25.2174 5 yes
GO:0120036 plasma membrane bounded cell projection organization 24.3478 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 23.4783 5 no
GO:0032880 regulation of protein localization 23.4783 5 yes
GO:0042981 regulation of apoptotic process 23.4783 5 yes
GO:0043067 regulation of programmed cell death 23.4783 4 yes
GO:0043933 protein-containing complex organization 23.4783 4 yes
GO:0048585 negative regulation of response to stimulus 23.4783 4 yes
GO:0009967 positive regulation of signal transduction 22.6087 5 no
GO:0010648 negative regulation of cell communication 22.6087 5 yes
GO:0023057 negative regulation of signaling 22.6087 4 yes
GO:0051252 regulation of RNA metabolic process 21.7391 5 no
GO:0009968 negative regulation of signal transduction 21.7391 5 yes
GO:0019220 regulation of phosphate metabolic process 21.7391 6 yes
GO:0031344 regulation of cell projection organization 21.7391 5 yes
GO:0051174 regulation of phosphorus metabolic process 21.7391 5 yes
GO:0051493 regulation of cytoskeleton organization 21.7391 6 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 20.8696 6 yes
GO:0009891 positive regulation of biosynthetic process 20.8696 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 20.8696 6 no
GO:0015031 protein transport 20.8696 4 no
GO:0031328 positive regulation of cellular biosynthetic process 20.8696 6 no
GO:0036211 protein modification process 20.8696 4 no
GO:0043412 macromolecule modification 20.8696 4 no
GO:0006355 regulation of DNA-templated transcription 20.8696 7 no
GO:2001141 regulation of RNA biosynthetic process 20.8696 6 no
GO:0009894 regulation of catabolic process 20.8696 4 yes
GO:0065003 protein-containing complex assembly 20.0000 5 yes
GO:0001932 regulation of protein phosphorylation 19.1304 7 yes
GO:0042325 regulation of phosphorylation 19.1304 7 yes
GO:0045595 regulation of cell differentiation 19.1304 4 yes
GO:0034330 cell junction organization 18.2609 4 yes
GO:1902903 regulation of supramolecular fiber organization 17.3913 5 yes
GO:2000145 regulation of cell motility 17.3913 4 yes
GO:0051129 negative regulation of cellular component organization 17.3913 5 yes
GO:0051240 positive regulation of multicellular organismal process 17.3913 4 yes
GO:0008285 negative regulation of cell population proliferation 16.5217 5 yes
GO:0030334 regulation of cell migration 16.5217 5 yes
GO:0044089 positive regulation of cellular component biogenesis 15.6522 5 yes
GO:0051248 negative regulation of protein metabolic process 15.6522 6 yes
GO:1903829 positive regulation of protein localization 14.7826 5 yes
GO:0031346 positive regulation of cell projection organization 14.7826 6 yes
GO:0042176 regulation of protein catabolic process 14.7826 5 yes
GO:0051726 regulation of cell cycle 14.7826 4 yes
GO:0016055 Wnt signaling pathway 13.9130 4 yes
GO:0051338 regulation of transferase activity 13.9130 4 yes
GO:0043549 regulation of kinase activity 13.0435 5 yes
GO:0045859 regulation of protein kinase activity 13.0435 6 yes
GO:0006508 proteolysis 12.1739 4 yes
GO:0034329 cell junction assembly 12.1739 5 yes
GO:2000147 positive regulation of cell motility 11.3043 5 yes
GO:0009896 positive regulation of catabolic process 11.3043 5 yes
GO:0030335 positive regulation of cell migration 11.3043 6 yes
GO:0032886 regulation of microtubule-based process 11.3043 4 yes
GO:0040017 positive regulation of locomotion 11.3043 4 yes
GO:0045216 cell-cell junction organization 11.3043 5 yes
GO:0031400 negative regulation of protein modification process 10.4348 7 yes
GO:0070507 regulation of microtubule cytoskeleton organization 9.5652 5 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 9.5652 4 yes
GO:0009057 macromolecule catabolic process 9.5652 4 yes
GO:0010563 negative regulation of phosphorus metabolic process 9.5652 6 yes
GO:0030111 regulation of Wnt signaling pathway 9.5652 5 yes
GO:0045732 positive regulation of protein catabolic process 9.5652 6 yes
GO:0045936 negative regulation of phosphate metabolic process 9.5652 7 yes
GO:1902904 negative regulation of supramolecular fiber organization 8.6957 6 yes
GO:0007043 cell-cell junction assembly 8.6957 6 yes
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 8.6957 5 yes
GO:0010639 negative regulation of organelle organization 8.6957 6 yes
GO:0043065 positive regulation of apoptotic process 8.6957 6 yes
GO:0043068 positive regulation of programmed cell death 8.6957 5 yes
GO:0051494 negative regulation of cytoskeleton organization 8.6957 7 yes
GO:0060491 regulation of cell projection assembly 7.8261 5 yes
GO:0060828 regulation of canonical Wnt signaling pathway 7.8261 6 yes
GO:0120032 regulation of plasma membrane bounded cell projection assembly 7.8261 6 yes
GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 7.8261 6 yes
GO:1901565 organonitrogen compound catabolic process 7.8261 4 yes
GO:0006974 DNA damage response 7.8261 4 yes
GO:0010564 regulation of cell cycle process 7.8261 5 yes
GO:0019941 modification-dependent protein catabolic process 7.8261 6 yes
GO:0030163 protein catabolic process 7.8261 4 yes
GO:0031110 regulation of microtubule polymerization or depolymerization 7.8261 6 yes
GO:0043632 modification-dependent macromolecule catabolic process 7.8261 5 yes
GO:0051603 proteolysis involved in protein catabolic process 7.8261 5 yes
GO:1901879 regulation of protein depolymerization 6.9565 6 yes
GO:1901880 negative regulation of protein depolymerization 6.9565 7 yes
GO:0001933 negative regulation of protein phosphorylation 6.9565 8 yes
GO:0006511 ubiquitin-dependent protein catabolic process 6.9565 7 yes
GO:0042326 negative regulation of phosphorylation 6.9565 8 yes
GO:0043086 negative regulation of catalytic activity 6.9565 4 yes
GO:0043242 negative regulation of protein-containing complex disassembly 6.9565 6 yes
GO:0043244 regulation of protein-containing complex disassembly 6.9565 5 yes
GO:0071900 regulation of protein serine/threonine kinase activity 6.0870 7 yes
GO:0007346 regulation of mitotic cell cycle 6.0870 5 yes
GO:0010498 proteasomal protein catabolic process 6.0870 5 yes
GO:0030178 negative regulation of Wnt signaling pathway 6.0870 6 yes
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 6.0870 6 yes
GO:0051348 negative regulation of transferase activity 6.0870 5 yes
GO:0061640 cytoskeleton-dependent cytokinesis 5.2174 4 yes
GO:0090090 negative regulation of canonical Wnt signaling pathway 5.2174 7 yes
GO:0006469 negative regulation of protein kinase activity 5.2174 7 yes
GO:0007399 nervous system development 5.2174 4 yes
GO:0033673 negative regulation of kinase activity 5.2174 6 yes
GO:0045786 negative regulation of cell cycle 5.2174 5 yes
GO:0070830 bicellular tight junction assembly 4.3478 8 yes
GO:0120192 tight junction assembly 4.3478 7 yes
GO:0120193 tight junction organization 4.3478 6 yes
GO:0000281 mitotic cytokinesis 4.3478 4 yes
GO:0045930 negative regulation of mitotic cell cycle 4.3478 6 yes
GO:0071901 negative regulation of protein serine/threonine kinase activity 3.4783 8 yes
GO:1904029 regulation of cyclin-dependent protein kinase activity 3.4783 5 yes
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 3.4783 6 yes
GO:0008286 insulin receptor signaling pathway 3.4783 6 yes
GO:0031111 negative regulation of microtubule polymerization or depolymerization 3.4783 7 yes
GO:0051783 regulation of nuclear division 2.6087 6 yes
GO:0051983 regulation of chromosome segregation 2.6087 6 yes
GO:0051988 regulation of attachment of spindle microtubules to kinetochore 2.6087 6 yes
GO:0120161 regulation of cold-induced thermogenesis 2.6087 4 yes
GO:0120162 positive regulation of cold-induced thermogenesis 2.6087 5 yes
GO:1901987 regulation of cell cycle phase transition 2.6087 6 yes
GO:1901988 negative regulation of cell cycle phase transition 2.6087 7 yes
GO:1901990 regulation of mitotic cell cycle phase transition 2.6087 6 yes
GO:1901991 negative regulation of mitotic cell cycle phase transition 2.6087 7 yes
GO:1902806 regulation of cell cycle G1/S phase transition 2.6087 7 yes
GO:1902807 negative regulation of cell cycle G1/S phase transition 2.6087 8 yes
GO:1904030 negative regulation of cyclin-dependent protein kinase activity 2.6087 6 yes
GO:1904779 regulation of protein localization to centrosome 2.6087 6 yes
GO:1904781 positive regulation of protein localization to centrosome 2.6087 6 yes
GO:1905818 regulation of chromosome separation 2.6087 7 yes
GO:2000045 regulation of G1/S transition of mitotic cell cycle 2.6087 7 yes
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle 2.6087 8 yes
GO:0007026 negative regulation of microtubule depolymerization 2.6087 7 yes
GO:0007088 regulation of mitotic nuclear division 2.6087 6 yes
GO:0010948 negative regulation of cell cycle process 2.6087 6 yes
GO:0031114 regulation of microtubule depolymerization 2.6087 6 yes
GO:0031272 regulation of pseudopodium assembly 2.6087 7 yes
GO:0031274 positive regulation of pseudopodium assembly 2.6087 7 yes
GO:0033044 regulation of chromosome organization 2.6087 6 yes
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity 2.6087 6 yes
GO:0051784 negative regulation of nuclear division 1.7391 7 yes
GO:0051985 negative regulation of chromosome segregation 1.7391 7 yes
GO:0060632 regulation of microtubule-based movement 1.7391 5 yes
GO:0071173 spindle assembly checkpoint signaling 1.7391 6 yes
GO:0071174 mitotic spindle checkpoint signaling 1.7391 5 yes
GO:0072132 mesenchyme morphogenesis 1.7391 4 yes
GO:1902099 regulation of metaphase/anaphase transition of cell cycle 1.7391 7 yes
GO:1902100 negative regulation of metaphase/anaphase transition of cell cycle 1.7391 8 yes
GO:1905819 negative regulation of chromosome separation 1.7391 8 yes
GO:2000816 negative regulation of mitotic sister chromatid separation 1.7391 9 yes
GO:2001251 negative regulation of chromosome organization 1.7391 7 yes
GO:0000075 cell cycle checkpoint signaling 1.7391 4 yes
GO:0003203 endocardial cushion morphogenesis 1.7391 5 yes
GO:0007093 mitotic cell cycle checkpoint signaling 1.7391 4 yes
GO:0007094 mitotic spindle assembly checkpoint signaling 1.7391 6 yes
GO:0010965 regulation of mitotic sister chromatid separation 1.7391 8 yes
GO:0030071 regulation of mitotic metaphase/anaphase transition 1.7391 7 yes
GO:0031577 spindle checkpoint signaling 1.7391 5 yes
GO:0033045 regulation of sister chromatid segregation 1.7391 7 yes
GO:0033046 negative regulation of sister chromatid segregation 1.7391 8 yes
GO:0033047 regulation of mitotic sister chromatid segregation 1.7391 8 yes
GO:0033048 negative regulation of mitotic sister chromatid segregation 1.7391 9 yes
GO:0045839 negative regulation of mitotic nuclear division 1.7391 7 yes
GO:0045841 negative regulation of mitotic metaphase/anaphase transition 1.7391 8 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MARE2_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG3_HUMAN [view entry] [view interactions] Low throughput yes yes
MUC1_HUMAN [view interactions] Low throughput no no
XPO1_HUMAN [view entry] [view interactions] Low throughput yes yes
APC_HUMAN [view entry] [view interactions] Low throughput yes no
AP2A_HUMAN [view interactions] Low throughput no no
CSK2B_HUMAN [view entry] [view interactions] Low throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] Low throughput yes no
MD2L1_HUMAN [view interactions] Low throughput no no
BUB3_HUMAN [view interactions] Low throughput no yes
AXIN2_HUMAN [view interactions] Low throughput no yes
ZRAN1_HUMAN [view interactions] Low throughput no yes
OTU7B_HUMAN [view interactions] Low throughput no yes
PCNA_HUMAN [view interactions] Low throughput no no
RFA2_HUMAN [view interactions] Low throughput no yes
STRN_HUMAN [view entry] [view interactions] Low throughput yes yes
STRN4_HUMAN [view entry] [view interactions] Low throughput yes yes
UBR5_HUMAN [view interactions] Low throughput no no
UBP7_HUMAN [view interactions] Low throughput no yes
MKRN1_HUMAN [view interactions] Low throughput no no
PRC1_HUMAN [view interactions] Low throughput no yes
AMER3_HUMAN [view interactions] Low throughput no no
RNF43_HUMAN [view interactions] Low throughput no yes
SPT13_HUMAN [view interactions] Low throughput no yes
CDC42_HUMAN [view entry] [view interactions] Low throughput yes yes
AXIN1_HUMAN [view interactions] Low throughput no yes
FBW1A_HUMAN [view interactions] Low throughput no yes
PAXI_HUMAN [view interactions] Low throughput no yes
KC1E_HUMAN [view entry] [view interactions] Low throughput yes yes
AMER2_HUMAN [view interactions] Low throughput no yes
AMER1_HUMAN [view interactions] Low throughput no yes
GSK3B_HUMAN [view entry] [view interactions] Low throughput yes yes
CTNA1_HUMAN [view entry] [view interactions] Low throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
CTBP1_HUMAN [view entry] [view interactions] Low throughput yes yes
DVL2_HUMAN [view interactions] Low throughput no yes
CRBN_HUMAN [view interactions] Low throughput no yes
PLAK_HUMAN [view entry] [view interactions] Low throughput yes yes
MARE1_HUMAN [view entry] [view interactions] Low throughput yes yes
NKD1_HUMAN [view interactions] Low throughput no no
CNBP1_HUMAN [view interactions] Low throughput no no
UBP15_HUMAN [view entry] [view interactions] Low throughput yes yes
KCTD1_HUMAN [view interactions] Low throughput no no
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
SCRIB_HUMAN [view entry] [view interactions] Low throughput yes no
DVLP1_HUMAN [view interactions] Low throughput no no
TBA4A_HUMAN [view entry] [view interactions] Low throughput yes yes
HTRA2_HUMAN [view interactions] Low throughput no yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
ASAP2_HUMAN [view interactions] Low throughput no yes
LRP8_HUMAN [view entry] [view interactions] Low throughput yes no
BUB1B_HUMAN [view interactions] Low throughput no no
KC1A_HUMAN [view interactions] Low throughput no yes
2A5A_HUMAN [view interactions] Low throughput no yes
EPCR_HUMAN [view interactions] Low throughput no yes
KIFA3_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE1_HUMAN [view entry] [view interactions] Low throughput yes yes
KIF3B_HUMAN [view entry] [view interactions] Low throughput yes no
KHDR1_HUMAN [view interactions] Low throughput no yes
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
RBP2_HUMAN [view interactions] Low throughput no yes
ASAP1_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE2_HUMAN [view entry] [view interactions] Low throughput yes no
PTN13_HUMAN [view interactions] Low throughput no yes
ARHG4_HUMAN [view interactions] Low throughput no yes
SIAH1_HUMAN [view interactions] Low throughput no yes
CSK21_HUMAN [view entry] [view interactions] Low throughput yes yes
BUB1_HUMAN [view interactions] Low throughput no no
STRN3_HUMAN [view entry] [view interactions] Low throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
NU4M_HUMAN [view interactions] High throughput no yes
HNRPM_HUMAN [view entry] [view interactions] High throughput yes yes
U520_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
CSN5_HUMAN [view interactions] High throughput no yes
TNKS1_HUMAN [view interactions] High throughput no yes
HECD1_HUMAN [view interactions] High throughput no yes
RN146_HUMAN [view interactions] High throughput no yes
CP250_HUMAN [view interactions] High throughput no no
AP2M1_HUMAN [view entry] [view interactions] High throughput yes yes
EF1D_HUMAN [view entry] [view interactions] High throughput yes yes
MARK2_HUMAN [view entry] [view interactions] High throughput yes yes
PKP2_HUMAN [view interactions] High throughput no yes
MBD4_HUMAN [view interactions] High throughput no yes
AKP13_HUMAN [view interactions] High throughput no yes
RFOX2_HUMAN [view interactions] High throughput no yes
SENP1_HUMAN [view entry] [view interactions] High throughput yes no
BBX_HUMAN [view interactions] High throughput no no
TRAF1_HUMAN [view interactions] High throughput no no
SYNCI_HUMAN [view interactions] High throughput no no
ACADV_HUMAN [view interactions] High throughput no yes
IQCN_HUMAN [view interactions] High throughput no no
ZN785_HUMAN [view interactions] High throughput no no
KC1D_HUMAN [view entry] [view interactions] High throughput yes yes
UBP30_HUMAN [view interactions] High throughput no yes
RN114_HUMAN [view interactions] High throughput no no
ZFP91_HUMAN [view interactions] High throughput no yes
TRI32_HUMAN [view entry] [view interactions] High throughput yes yes
HEY1_HUMAN [view interactions] High throughput no yes
RNF31_HUMAN [view interactions] High throughput no yes
SMU1_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
PP1G_HUMAN [view entry] [view interactions] High throughput yes yes
KIF14_HUMAN [view interactions] High throughput no no
KIF23_HUMAN [view interactions] High throughput no yes
RIGI_HUMAN [view interactions] High throughput no yes
KRT38_HUMAN [view interactions] High throughput no no
TX1B3_HUMAN [view interactions] High throughput no no
SULF2_HUMAN [view interactions] High throughput no yes
SLU7_HUMAN [view interactions] High throughput no yes
ZBT44_HUMAN [view interactions] High throughput no yes
C2C4B_HUMAN [view interactions] High throughput no no
DVL1_HUMAN [view entry] [view interactions] High throughput yes yes
NET5_HUMAN [view interactions] High throughput no no
RN145_HUMAN [view interactions] High throughput no yes
COQ3_HUMAN [view interactions] High throughput no no
FHL2_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
BL1S6_HUMAN [view interactions] High throughput no yes
SAV1_HUMAN [view interactions] High throughput no yes
S35G1_HUMAN [view interactions] High throughput no no
CCD71_HUMAN [view interactions] High throughput no no
K1C17_HUMAN [view interactions] High throughput no no
EMIL3_HUMAN [view interactions] High throughput no yes
MD1L1_HUMAN [view interactions] High throughput no yes
SPB1_HUMAN [view interactions] High throughput no yes
ENTP1_HUMAN [view interactions] High throughput no yes
RM18_HUMAN [view interactions] High throughput no yes
MAP10_HUMAN [view interactions] High throughput no no
TELO2_HUMAN [view interactions] High throughput no yes
KRT37_HUMAN [view interactions] High throughput no no
LIN7B_HUMAN [view entry] [view interactions] High throughput yes no
FA83B_HUMAN [view interactions] High throughput no no
RUVB2_HUMAN [view interactions] High throughput no yes
YM012_HUMAN [view interactions] High throughput no no
SLN11_HUMAN [view interactions] High throughput no yes
RHG21_HUMAN [view entry] [view interactions] High throughput yes yes
SIR6_HUMAN [view interactions] High throughput no yes
WIZ_HUMAN [view interactions] High throughput no yes
RBCC1_HUMAN [view interactions] High throughput no no
PLK4_HUMAN [view interactions] High throughput no yes
FLOT2_HUMAN [view entry] [view interactions] High throughput yes yes
TRAP1_HUMAN [view entry] [view interactions] High throughput yes yes
TNKS2_HUMAN [view interactions] High throughput no no
COPZ1_HUMAN [view interactions] High throughput no no
FBW1B_HUMAN [view interactions] High throughput no yes
DDX21_HUMAN [view interactions] High throughput no yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
TBB4B_HUMAN [view interactions] High throughput no yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
NHSL1_HUMAN [view interactions] High throughput no yes
MARH5_HUMAN [view interactions] High throughput no no
KIF7_HUMAN [view interactions] High throughput no yes
PARPT_HUMAN [view interactions] High throughput no no
LZTS2_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
LIN7C_HUMAN [view entry] [view interactions] High throughput yes yes
GSK3A_HUMAN [view interactions] High throughput no yes
ZN408_HUMAN [view interactions] High throughput no no
CTNA3_HUMAN [view interactions] High throughput no no
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
CCDC6_HUMAN [view interactions] High throughput no yes
CDK9_HUMAN [view interactions] High throughput no yes
VHL_HUMAN [view entry] [view interactions] High throughput yes yes
NOLC1_HUMAN [view interactions] High throughput no yes
SNF5_HUMAN [view interactions] High throughput no yes
TIF1B_HUMAN [view interactions] High throughput no yes
ALDH2_HUMAN [view entry] [view interactions] High throughput yes no
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
DCC_HUMAN [view entry] [view interactions] High throughput yes yes
MCM5_HUMAN [view interactions] High throughput no no
CDK4_HUMAN [view interactions] High throughput no no
DDB1_HUMAN [view interactions] High throughput no yes
I22R1_HUMAN [view interactions] High throughput no no
SC23A_HUMAN [view entry] [view interactions] High throughput yes yes
IL22_HUMAN [view interactions] High throughput no no
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
PK3CA_HUMAN [view entry] [view interactions] High throughput yes yes
APCL_HUMAN [view entry] [view interactions] High throughput yes no
CSKP_HUMAN [view entry] [view interactions] High throughput yes yes
PLK1_HUMAN [view interactions] High throughput no yes
K1C9_HUMAN [view interactions] High throughput no no
K2C1_HUMAN [view interactions] High throughput no no
IGHA1_HUMAN [view entry] [view interactions] High throughput yes yes
NU107_HUMAN [view interactions] High throughput no no
HOOK3_HUMAN [view entry] [view interactions] High throughput yes yes
PTBP3_HUMAN [view interactions] High throughput no no
NIN_HUMAN [view interactions] High throughput no no
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
F120C_HUMAN [view interactions] High throughput no yes
MYCB2_HUMAN [view entry] [view interactions] High throughput yes no
PATL1_HUMAN [view interactions] High throughput no yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
SMAG2_HUMAN [view interactions] High throughput no yes
HDAC4_HUMAN [view interactions] High throughput no yes
CEP85_HUMAN [view interactions] High throughput no no
CNOT9_HUMAN [view interactions] High throughput no yes
MKRN2_HUMAN [view interactions] High throughput no yes
KIF3A_HUMAN [view entry] [view interactions] High throughput yes yes
ARP3_HUMAN [view entry] [view interactions] High throughput yes yes
AMOT_HUMAN [view entry] [view interactions] High throughput yes no
ANC2_HUMAN [view interactions] High throughput no no
B3GA1_HUMAN [view interactions] High throughput no yes
FA20C_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
AN32B_HUMAN [view interactions] High throughput no yes
CP135_HUMAN [view interactions] High throughput no no
BAAT_HUMAN [view interactions] High throughput no no
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
TSTD2_HUMAN [view interactions] High throughput no yes
E41LA_HUMAN [view interactions] High throughput no yes
CATL2_HUMAN [view interactions] High throughput no yes
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
FANCC_HUMAN [view interactions] High throughput no yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
MP2K1_HUMAN [view entry] [view interactions] High throughput yes yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
F16P1_HUMAN [view interactions] High throughput no no
GOGA1_HUMAN [view interactions] High throughput no yes
SIAS_HUMAN [view interactions] High throughput no yes
KDM1A_HUMAN [view interactions] High throughput no yes
CANB2_HUMAN [view interactions] High throughput no no
K1C18_HUMAN [view interactions] High throughput no no
RASA1_HUMAN [view interactions] High throughput no yes
K2C8_HUMAN [view interactions] High throughput no no
SMAD1_HUMAN [view interactions] High throughput no yes
LATS1_HUMAN [view entry] [view interactions] High throughput yes yes
TGFB1_HUMAN [view interactions] High throughput no no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
TEFF1_HUMAN [view interactions] High throughput no no
MARE3_HUMAN [view entry] [view interactions] High throughput yes yes
TMOD1_HUMAN [view entry] [view interactions] High throughput yes yes
AFAD_HUMAN [view entry] [view interactions] High throughput yes yes
ZN510_HUMAN [view interactions] High throughput no yes
OCLN_HUMAN [view interactions] High throughput no no
AGR3_HUMAN [view interactions] High throughput no no
PARD3_HUMAN [view interactions] High throughput no yes
CCL5_HUMAN [view interactions] High throughput no no
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
CASC3_HUMAN [view interactions] High throughput no yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
CP17A_HUMAN [view interactions] High throughput no no
SEP10_HUMAN [view interactions] High throughput no yes
DKK3_HUMAN [view interactions] High throughput no yes
STIL_HUMAN [view interactions] High throughput no no
DIRA3_HUMAN [view interactions] High throughput no yes
STX4_HUMAN [view entry] [view interactions] High throughput yes no
HXC6_HUMAN [view interactions] High throughput no no
SYNE3_HUMAN [view interactions] High throughput no no
IL24_HUMAN [view interactions] High throughput no no
ZO2_HUMAN [view entry] [view interactions] High throughput yes no
ARY2_HUMAN [view interactions] High throughput no no
TRI36_HUMAN [view interactions] High throughput no no
PDLI2_HUMAN [view interactions] High throughput no no
ZFPL1_HUMAN [view interactions] High throughput no yes
ST14_HUMAN [view entry] [view interactions] High throughput yes yes
ZYX_HUMAN [view interactions] High throughput no no
TFF1_HUMAN [view interactions] High throughput no no
TAXB1_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
PHLP1_HUMAN [view interactions] High throughput no yes
AP2B1_HUMAN [view entry] [view interactions] High throughput yes yes
AR13B_HUMAN [view interactions] High throughput no yes
ANXA7_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC1_HUMAN [view interactions] High throughput no no
ANR17_HUMAN [view interactions] High throughput no yes
PF21A_HUMAN [view interactions] High throughput no yes
ACTN1_HUMAN [view entry] [view interactions] High throughput yes yes
RCOR1_HUMAN [view interactions] High throughput no yes
CGNL1_HUMAN [view interactions] High throughput no no
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
SMC3_HUMAN [view entry] [view interactions] High throughput yes yes
RICTR_HUMAN [view interactions] High throughput no yes
CBP_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
COG5_HUMAN [view interactions] High throughput no yes
DCAF4_HUMAN [view interactions] High throughput no yes
COG4_HUMAN [view interactions] High throughput no no
NUP43_HUMAN [view interactions] High throughput no yes
DYST_HUMAN [view entry] [view interactions] High throughput yes yes
RFA4_HUMAN [view interactions] High throughput no yes
EPAS1_HUMAN [view interactions] High throughput no no
AGFG1_HUMAN [view interactions] High throughput no yes
HGS_HUMAN [view entry] [view interactions] High throughput yes yes
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
ERBIN_HUMAN [view entry] [view interactions] High throughput yes yes
FBX30_HUMAN [view interactions] High throughput no yes
FHOD1_HUMAN [view interactions] High throughput no no
KINH_HUMAN [view entry] [view interactions] High throughput yes no
ING5_HUMAN [view interactions] High throughput no yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
K1C13_HUMAN [view interactions] High throughput no no
K1C14_HUMAN [view interactions] High throughput no no
K1C23_HUMAN [view interactions] High throughput no no
AGRL1_HUMAN [view interactions] High throughput no no
LAMA4_HUMAN [view interactions] High throughput no no
LAMA3_HUMAN [view interactions] High throughput no no
K2C5_HUMAN [view entry] [view interactions] High throughput yes no
K1C19_HUMAN [view interactions] High throughput no no
K1C15_HUMAN [view interactions] High throughput no no
MACF1_HUMAN [view entry] [view interactions] High throughput yes yes
GANP_HUMAN [view interactions] High throughput no yes
MBD5_HUMAN [view interactions] High throughput no no
MYH10_HUMAN [view entry] [view interactions] High throughput yes yes
MYH11_HUMAN [view entry] [view interactions] High throughput yes no
NCKP5_HUMAN [view interactions] High throughput no no
NAV1_HUMAN [view interactions] High throughput no yes
NAV2_HUMAN [view interactions] High throughput no yes
NAV3_HUMAN [view interactions] High throughput no yes
MYO6_HUMAN [view entry] [view interactions] High throughput yes no
NU153_HUMAN [view interactions] High throughput no yes
NEBU_HUMAN [view interactions] High throughput no no
NU214_HUMAN [view interactions] High throughput no no
NUP42_HUMAN [view interactions] High throughput no no
NUP58_HUMAN [view interactions] High throughput no yes
NUP98_HUMAN [view interactions] High throughput no no
NUP54_HUMAN [view interactions] High throughput no yes
P121A_HUMAN [view interactions] High throughput no yes
ASPP1_HUMAN [view interactions] High throughput no yes
RANB9_HUMAN [view entry] [view interactions] High throughput yes yes
PSMD1_HUMAN [view entry] [view interactions] High throughput yes yes
RBM4B_HUMAN [view interactions] High throughput no yes
CYH2_HUMAN [view entry] [view interactions] High throughput yes yes
SC31A_HUMAN [view entry] [view interactions] High throughput yes yes
SETB1_HUMAN [view interactions] High throughput no yes
RS27_HUMAN [view entry] [view interactions] High throughput yes no
SPTB2_HUMAN [view entry] [view interactions] High throughput yes yes
SPTN2_HUMAN [view entry] [view interactions] High throughput yes yes
SYNE1_HUMAN [view entry] [view interactions] High throughput yes yes
TAF1_HUMAN [view interactions] High throughput no yes
EXPH5_HUMAN [view interactions] High throughput no no
RO52_HUMAN [view interactions] High throughput no yes
TPR_HUMAN [view interactions] High throughput no yes
ZN106_HUMAN [view interactions] High throughput no no
NOSTN_HUMAN [view interactions] High throughput no yes
CYTSA_HUMAN [view interactions] High throughput no yes
PNISR_HUMAN [view interactions] High throughput no yes
P121C_HUMAN [view interactions] High throughput no yes
NCK5L_HUMAN [view interactions] High throughput no yes
GGYF2_HUMAN [view interactions] High throughput no yes
ATOSA_HUMAN [view interactions] High throughput no yes
K1328_HUMAN [view interactions] High throughput no yes
CO4A_HUMAN [view interactions] High throughput no no
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
CKAP5_HUMAN [view entry] [view interactions] High throughput yes yes
ESR1_HUMAN [view interactions] High throughput no no
PKNX1_HUMAN [view interactions] High throughput no yes
FAK1_HUMAN [view entry] [view interactions] High throughput yes yes
ANR28_HUMAN [view interactions] High throughput no no
LATS2_HUMAN [view interactions] High throughput no yes
FTM_HUMAN [view interactions] High throughput no yes
CE128_HUMAN [view interactions] High throughput no yes
SAS6_HUMAN [view interactions] High throughput no no
TOM20_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR4_HUMAN [view interactions] High throughput no no
FHI2A_HUMAN [view interactions] High throughput no yes
HOOK2_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
KCNK3_HUMAN [view interactions] High throughput no no
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes