SPTN2_HUMAN
Evidence for PS localization
Functions
Probably plays an important role in neuronal membrane skeleton. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SPTN2_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 39.1892 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 39.1892 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 37.8378 | 4 | no |
| GO:0019900 | kinase binding | 32.4324 | 4 | no |
| GO:0019901 | protein kinase binding | 32.4324 | 5 | no |
| GO:0003779 | actin binding | 22.9730 | 4 | yes |
| GO:0005525 | GTP binding | 22.9730 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 22.9730 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 22.9730 | 5 | no |
| GO:0003924 | GTPase activity | 21.6216 | 7 | no |
| GO:0016462 | pyrophosphatase activity | 21.6216 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 21.6216 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 21.6216 | 6 | no |
| GO:0045296 | cadherin binding | 17.5676 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SPTN2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 58.1081 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 56.7568 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 51.3514 | 4 | yes |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | no |
| GO:0006996 | organelle organization | 48.6486 | 4 | yes |
| GO:0022607 | cellular component assembly | 45.9459 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 45.9459 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 43.2432 | 4 | no |
| GO:0009966 | regulation of signal transduction | 43.2432 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 40.5405 | 4 | no |
| GO:0008104 | protein localization | 40.5405 | 4 | no |
| GO:0033043 | regulation of organelle organization | 39.1892 | 5 | yes |
| GO:0031323 | regulation of cellular metabolic process | 39.1892 | 4 | no |
| GO:0007010 | cytoskeleton organization | 36.4865 | 5 | yes |
| GO:0016192 | vesicle-mediated transport | 36.4865 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 36.4865 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 36.4865 | 5 | no |
| GO:0030030 | cell projection organization | 36.4865 | 4 | no |
| GO:0051049 | regulation of transport | 36.4865 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 35.1351 | 6 | yes |
| GO:0051246 | regulation of protein metabolic process | 35.1351 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 33.7838 | 5 | no |
| GO:0032970 | regulation of actin filament-based process | 32.4324 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 32.4324 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 32.4324 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 32.4324 | 4 | no |
| GO:0023056 | positive regulation of signaling | 31.0811 | 4 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 29.7297 | 5 | yes |
| GO:0010468 | regulation of gene expression | 29.7297 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 29.7297 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 28.3784 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 28.3784 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 28.3784 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 28.3784 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 27.0270 | 6 | no |
| GO:0010941 | regulation of cell death | 27.0270 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 27.0270 | 5 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 25.6757 | 5 | yes |
| GO:0071310 | cellular response to organic substance | 25.6757 | 4 | no |
| GO:0071702 | organic substance transport | 25.6757 | 4 | no |
| GO:0071705 | nitrogen compound transport | 25.6757 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 24.3243 | 5 | yes |
| GO:0042981 | regulation of apoptotic process | 24.3243 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 24.3243 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 24.3243 | 5 | no |
| GO:0034330 | cell junction organization | 22.9730 | 4 | yes |
| GO:0110053 | regulation of actin filament organization | 22.9730 | 6 | yes |
| GO:0031399 | regulation of protein modification process | 22.9730 | 6 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.9730 | 6 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 22.9730 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 22.9730 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.9730 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 21.6216 | 4 | no |
| GO:0032880 | regulation of protein localization | 21.6216 | 5 | no |
| GO:0036211 | protein modification process | 21.6216 | 4 | no |
| GO:0043412 | macromolecule modification | 21.6216 | 4 | no |
| GO:0060341 | regulation of cellular localization | 21.6216 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 21.6216 | 5 | no |
| GO:0051050 | positive regulation of transport | 21.6216 | 4 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 21.6216 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 21.6216 | 4 | no |
| GO:0043254 | regulation of protein-containing complex assembly | 20.2703 | 5 | yes |
| GO:0015031 | protein transport | 20.2703 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 20.2703 | 7 | no |
| GO:0032535 | regulation of cellular component size | 17.5676 | 4 | yes |
| GO:0032271 | regulation of protein polymerization | 16.2162 | 6 | yes |
| GO:0050808 | synapse organization | 16.2162 | 5 | yes |
| GO:0008064 | regulation of actin polymerization or depolymerization | 14.8649 | 6 | yes |
| GO:0010639 | negative regulation of organelle organization | 14.8649 | 6 | yes |
| GO:0030832 | regulation of actin filament length | 14.8649 | 5 | yes |
| GO:0034329 | cell junction assembly | 14.8649 | 5 | yes |
| GO:0030833 | regulation of actin filament polymerization | 13.5135 | 7 | yes |
| GO:0031333 | negative regulation of protein-containing complex assembly | 10.8108 | 6 | yes |
| GO:0051494 | negative regulation of cytoskeleton organization | 10.8108 | 7 | yes |
| GO:1902904 | negative regulation of supramolecular fiber organization | 10.8108 | 6 | yes |
| GO:0043244 | regulation of protein-containing complex disassembly | 9.4595 | 5 | yes |
| GO:0043242 | negative regulation of protein-containing complex disassembly | 8.1081 | 6 | yes |
| GO:1901879 | regulation of protein depolymerization | 8.1081 | 6 | yes |
| GO:1901880 | negative regulation of protein depolymerization | 8.1081 | 7 | yes |
| GO:0007416 | synapse assembly | 6.7568 | 6 | yes |
| GO:0030834 | regulation of actin filament depolymerization | 6.7568 | 7 | yes |
| GO:0030835 | negative regulation of actin filament depolymerization | 6.7568 | 7 | yes |
| GO:0030837 | negative regulation of actin filament polymerization | 6.7568 | 7 | yes |
| GO:0032272 | negative regulation of protein polymerization | 6.7568 | 7 | yes |
| GO:0051693 | actin filament capping | 6.7568 | 8 | yes |
| GO:0099173 | postsynapse organization | 6.7568 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in SPTN2_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 4.0541 | 3 | no |
| DOID:0050701 | electroclinical syndrome | 2.7027 | 6 | no |
| DOID:0112202 | developmental and epileptic encephalopathy | 2.7027 | 7 | no |
| DOID:1826 | epilepsy | 2.7027 | 5 | no |
| DOID:936 | brain disease | 2.7027 | 4 | no |
| DOID:114 | heart disease | 2.7027 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| UN13B_HUMAN | [view interactions] | Low throughput | no | no |
| ACTZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SPTN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CELR3_HUMAN | [view interactions] | High throughput | no | no |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BOD1_HUMAN | [view interactions] | High throughput | no | yes |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATAD2_HUMAN | [view interactions] | High throughput | no | no |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ASF1A_HUMAN | [view interactions] | High throughput | no | no |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SGTB_HUMAN | [view interactions] | High throughput | no | yes |
| SORT_HUMAN | [view interactions] | High throughput | no | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| MLH1_HUMAN | [view interactions] | High throughput | no | yes |
| SNF5_HUMAN | [view interactions] | High throughput | no | yes |
| CHK2_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCRB2_HUMAN | [view interactions] | High throughput | no | yes |
| DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBCK_HUMAN | [view interactions] | High throughput | no | yes |
| HASP_HUMAN | [view interactions] | High throughput | no | yes |
| CNKR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HOME1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NCKP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KALRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| APC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDK1_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTDSL_HUMAN | [view interactions] | High throughput | no | no |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2A_HUMAN | [view interactions] | High throughput | no | no |
| CACO2_HUMAN | [view interactions] | High throughput | no | yes |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| K1C17_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| RU17_HUMAN | [view interactions] | High throughput | no | yes |
| GRIA4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| ZCH18_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| AKT3_HUMAN | [view interactions] | High throughput | no | yes |
| NUDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIFA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSUH2_HUMAN | [view interactions] | High throughput | no | no |
| MBNL1_HUMAN | [view interactions] | High throughput | no | yes |
| BHE23_HUMAN | [view interactions] | High throughput | no | no |
| NOLC1_HUMAN | [view interactions] | High throughput | no | yes |
| CC113_HUMAN | [view interactions] | High throughput | no | no |
| ABRA_HUMAN | [view interactions] | High throughput | no | no |
| CR021_HUMAN | [view interactions] | High throughput | no | no |
| NEMO_HUMAN | [view interactions] | High throughput | no | yes |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| KGD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NIPA_HUMAN | [view interactions] | High throughput | no | yes |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| TFR1_HUMAN | [view interactions] | High throughput | no | yes |
| CATL1_HUMAN | [view interactions] | High throughput | no | yes |
| CATB_HUMAN | [view interactions] | High throughput | no | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| CLC4D_HUMAN | [view interactions] | High throughput | no | no |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KDM5C_HUMAN | [view interactions] | High throughput | no | no |
| COR1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EXOC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ILF2_HUMAN | [view interactions] | High throughput | no | yes |
| CNDD3_HUMAN | [view interactions] | High throughput | no | no |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DYLT1_HUMAN | [view interactions] | High throughput | no | no |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| ANK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI1_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LMAN1_HUMAN | [view interactions] | High throughput | no | yes |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| KCNQ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRM1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PKHG4_HUMAN | [view interactions] | Computational | no | no |
| ANK2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SPTN4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| SRC_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| SPTN5_HUMAN | [view interactions] | Computational | no | no |
| EAA4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |