SPTN2_HUMAN
Probably plays an important role in neuronal membrane skeleton. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in SPTN2_HUMAN |
---|---|---|---|---|
GO:0043168 | anion binding | 40.7895 | 4 | no |
GO:0000166 | nucleotide binding | 39.4737 | 4 | no |
GO:0017076 | purine nucleotide binding | 39.4737 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 39.4737 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 38.1579 | 4 | no |
GO:0019900 | kinase binding | 32.8947 | 4 | no |
GO:0019901 | protein kinase binding | 32.8947 | 5 | no |
GO:0003779 | actin binding | 22.3684 | 4 | yes |
GO:0005525 | GTP binding | 22.3684 | 5 | no |
GO:0019001 | guanyl nucleotide binding | 22.3684 | 6 | no |
GO:0032561 | guanyl ribonucleotide binding | 22.3684 | 5 | no |
GO:0043169 | cation binding | 21.0526 | 4 | no |
GO:0045296 | cadherin binding | 15.7895 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in SPTN2_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 63.1579 | 4 | no |
GO:0051128 | regulation of cellular component organization | 59.2105 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 51.3158 | 4 | yes |
GO:0006996 | organelle organization | 50.0000 | 4 | yes |
GO:0010646 | regulation of cell communication | 50.0000 | 4 | no |
GO:0022607 | cellular component assembly | 47.3684 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 47.3684 | 4 | no |
GO:0008104 | protein localization | 46.0526 | 4 | no |
GO:0009966 | regulation of signal transduction | 43.4211 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 42.1053 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 40.7895 | 4 | no |
GO:0033043 | regulation of organelle organization | 38.1579 | 5 | yes |
GO:0009893 | positive regulation of metabolic process | 38.1579 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 38.1579 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 36.8421 | 5 | no |
GO:0044087 | regulation of cellular component biogenesis | 35.5263 | 4 | yes |
GO:0030030 | cell projection organization | 35.5263 | 4 | no |
GO:0007010 | cytoskeleton organization | 34.2105 | 5 | yes |
GO:0009889 | regulation of biosynthetic process | 34.2105 | 4 | no |
GO:0010468 | regulation of gene expression | 34.2105 | 6 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 34.2105 | 5 | no |
GO:0010647 | positive regulation of cell communication | 34.2105 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 34.2105 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 34.2105 | 4 | no |
GO:0023056 | positive regulation of signaling | 32.8947 | 4 | no |
GO:0051493 | regulation of cytoskeleton organization | 31.5789 | 6 | yes |
GO:0009967 | positive regulation of signal transduction | 31.5789 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 30.2632 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 30.2632 | 5 | no |
GO:0032970 | regulation of actin filament-based process | 28.9474 | 4 | yes |
GO:0031344 | regulation of cell projection organization | 28.9474 | 5 | no |
GO:0042981 | regulation of apoptotic process | 28.9474 | 5 | no |
GO:0043067 | regulation of programmed cell death | 28.9474 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 28.9474 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 28.9474 | 6 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 28.9474 | 6 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 28.9474 | 5 | no |
GO:0060341 | regulation of cellular localization | 27.6316 | 4 | no |
GO:0032956 | regulation of actin cytoskeleton organization | 26.3158 | 5 | yes |
GO:0051049 | regulation of transport | 26.3158 | 4 | no |
GO:0071702 | organic substance transport | 26.3158 | 4 | no |
GO:0032880 | regulation of protein localization | 26.3158 | 5 | no |
GO:0051129 | negative regulation of cellular component organization | 25.0000 | 5 | yes |
GO:1902903 | regulation of supramolecular fiber organization | 25.0000 | 5 | yes |
GO:0031399 | regulation of protein modification process | 25.0000 | 6 | no |
GO:0071705 | nitrogen compound transport | 25.0000 | 4 | no |
GO:0141124 | intracellular signaling cassette | 25.0000 | 4 | no |
GO:0019220 | regulation of phosphate metabolic process | 23.6842 | 6 | no |
GO:0042325 | regulation of phosphorylation | 23.6842 | 7 | no |
GO:0051174 | regulation of phosphorus metabolic process | 23.6842 | 5 | no |
GO:0034330 | cell junction organization | 22.3684 | 4 | yes |
GO:0110053 | regulation of actin filament organization | 22.3684 | 6 | yes |
GO:0001932 | regulation of protein phosphorylation | 22.3684 | 7 | no |
GO:0051240 | positive regulation of multicellular organismal process | 22.3684 | 4 | no |
GO:1902533 | positive regulation of intracellular signal transduction | 22.3684 | 6 | no |
GO:0006915 | apoptotic process | 21.0526 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 21.0526 | 4 | no |
GO:0030155 | regulation of cell adhesion | 21.0526 | 4 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 21.0526 | 4 | no |
GO:0015031 | protein transport | 21.0526 | 4 | no |
GO:0043066 | negative regulation of apoptotic process | 21.0526 | 6 | no |
GO:0043069 | negative regulation of programmed cell death | 21.0526 | 5 | no |
GO:0043933 | protein-containing complex organization | 21.0526 | 4 | no |
GO:1903829 | positive regulation of protein localization | 21.0526 | 5 | no |
GO:0043254 | regulation of protein-containing complex assembly | 19.7368 | 5 | yes |
GO:0050808 | synapse organization | 17.1053 | 5 | yes |
GO:0032535 | regulation of cellular component size | 15.7895 | 4 | yes |
GO:0010639 | negative regulation of organelle organization | 14.4737 | 6 | yes |
GO:0032271 | regulation of protein polymerization | 13.1579 | 6 | yes |
GO:0034329 | cell junction assembly | 13.1579 | 5 | yes |
GO:0008064 | regulation of actin polymerization or depolymerization | 11.8421 | 6 | yes |
GO:0030832 | regulation of actin filament length | 11.8421 | 5 | yes |
GO:0051494 | negative regulation of cytoskeleton organization | 11.8421 | 7 | yes |
GO:1902904 | negative regulation of supramolecular fiber organization | 11.8421 | 6 | yes |
GO:0030833 | regulation of actin filament polymerization | 10.5263 | 7 | yes |
GO:0031333 | negative regulation of protein-containing complex assembly | 9.2105 | 6 | yes |
GO:0043244 | regulation of protein-containing complex disassembly | 9.2105 | 5 | yes |
GO:0043242 | negative regulation of protein-containing complex disassembly | 7.8947 | 6 | yes |
GO:1901879 | regulation of protein depolymerization | 7.8947 | 6 | yes |
GO:1901880 | negative regulation of protein depolymerization | 7.8947 | 7 | yes |
GO:0007416 | synapse assembly | 6.5789 | 6 | yes |
GO:0030834 | regulation of actin filament depolymerization | 6.5789 | 7 | yes |
GO:0030835 | negative regulation of actin filament depolymerization | 6.5789 | 7 | yes |
GO:0030837 | negative regulation of actin filament polymerization | 5.2632 | 7 | yes |
GO:0032272 | negative regulation of protein polymerization | 5.2632 | 7 | yes |
GO:0051693 | actin filament capping | 5.2632 | 8 | yes |
GO:1902115 | regulation of organelle assembly | 5.2632 | 5 | yes |
GO:0099150 | regulation of postsynaptic specialization assembly | 2.6316 | 6 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
UN13B_HUMAN | [view interactions] | Low throughput | no | no |
ACTZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AP2A2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SPTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ACTB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
SPTN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CELR3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AURKB_HUMAN | [view interactions] | High throughput | no | yes |
MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYO19_HUMAN | [view interactions] | High throughput | no | yes |
FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
BOD1_HUMAN | [view interactions] | High throughput | no | yes |
CALL3_HUMAN | [view interactions] | High throughput | no | yes |
SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ATAD2_HUMAN | [view interactions] | High throughput | no | no |
MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ASF1A_HUMAN | [view interactions] | High throughput | no | no |
PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SGTB_HUMAN | [view interactions] | High throughput | no | yes |
SORT_HUMAN | [view interactions] | High throughput | no | yes |
KSR1_HUMAN | [view interactions] | High throughput | no | yes |
MOT11_HUMAN | [view interactions] | High throughput | no | no |
MLH1_HUMAN | [view interactions] | High throughput | no | yes |
SNF5_HUMAN | [view interactions] | High throughput | no | yes |
CHK2_HUMAN | [view interactions] | High throughput | no | yes |
NF2L2_HUMAN | [view interactions] | High throughput | no | yes |
PK3CA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SCRB2_HUMAN | [view interactions] | High throughput | no | yes |
DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBCK_HUMAN | [view interactions] | High throughput | no | yes |
HASP_HUMAN | [view interactions] | High throughput | no | yes |
CNKR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HOME1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NCKP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
KALRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
BMI1_HUMAN | [view interactions] | High throughput | no | yes |
ANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CK5P2_HUMAN | [view interactions] | High throughput | no | yes |
CEP63_HUMAN | [view interactions] | High throughput | no | yes |
APC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CDK1_HUMAN | [view interactions] | High throughput | no | no |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PCNT_HUMAN | [view interactions] | High throughput | no | yes |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CTDSL_HUMAN | [view interactions] | High throughput | no | no |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
KCNK3_HUMAN | [view interactions] | High throughput | no | no |
SIR7_HUMAN | [view interactions] | High throughput | no | yes |
OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
TRI25_HUMAN | [view interactions] | High throughput | no | yes |
UBE2A_HUMAN | [view interactions] | High throughput | no | no |
CACO2_HUMAN | [view interactions] | High throughput | no | yes |
RN123_HUMAN | [view interactions] | High throughput | no | yes |
K1C17_HUMAN | [view interactions] | High throughput | no | no |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
APEX1_HUMAN | [view interactions] | High throughput | no | yes |
RU17_HUMAN | [view interactions] | High throughput | no | yes |
GRIA4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PINK1_HUMAN | [view interactions] | High throughput | no | yes |
YAP1_HUMAN | [view interactions] | High throughput | no | yes |
TFCP2_HUMAN | [view interactions] | High throughput | no | no |
ZCH18_HUMAN | [view interactions] | High throughput | no | yes |
CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ANLN_HUMAN | [view interactions] | High throughput | no | yes |
CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
ECT2_HUMAN | [view interactions] | High throughput | no | no |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
KI20A_HUMAN | [view interactions] | High throughput | no | yes |
PRC1_HUMAN | [view interactions] | High throughput | no | yes |
AKT3_HUMAN | [view interactions] | High throughput | no | yes |
NUDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KIFA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SSUH2_HUMAN | [view interactions] | High throughput | no | no |
MBNL1_HUMAN | [view interactions] | High throughput | no | yes |
BHE23_HUMAN | [view interactions] | High throughput | no | no |
NOLC1_HUMAN | [view interactions] | High throughput | no | yes |
CC113_HUMAN | [view interactions] | High throughput | no | no |
ABRA_HUMAN | [view interactions] | High throughput | no | no |
CR021_HUMAN | [view interactions] | High throughput | no | no |
NEMO_HUMAN | [view interactions] | High throughput | no | yes |
CCR1_HUMAN | [view interactions] | High throughput | no | no |
KGD4_HUMAN | [view interactions] | High throughput | no | yes |
ZC3C1_HUMAN | [view interactions] | High throughput | no | yes |
TOP3B_HUMAN | [view interactions] | High throughput | no | no |
TFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CATL1_HUMAN | [view interactions] | High throughput | no | yes |
CATB_HUMAN | [view interactions] | High throughput | no | yes |
IFM1_HUMAN | [view interactions] | High throughput | no | no |
DPP4_HUMAN | [view interactions] | High throughput | no | no |
IFM3_HUMAN | [view interactions] | High throughput | no | yes |
CLC4D_HUMAN | [view interactions] | High throughput | no | no |
CLC4E_HUMAN | [view interactions] | High throughput | no | no |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
RHOQ_HUMAN | [view interactions] | High throughput | no | no |
RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOC_HUMAN | [view interactions] | High throughput | no | no |
RHOD_HUMAN | [view interactions] | High throughput | no | no |
RHOF_HUMAN | [view interactions] | High throughput | no | no |
RHOU_HUMAN | [view interactions] | High throughput | no | no |
RHOH_HUMAN | [view interactions] | High throughput | no | yes |
RND1_HUMAN | [view interactions] | High throughput | no | no |
RND3_HUMAN | [view interactions] | High throughput | no | no |
SOX2_HUMAN | [view interactions] | High throughput | no | yes |
CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ANM1_HUMAN | [view interactions] | High throughput | no | yes |
PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
UBP53_HUMAN | [view interactions] | High throughput | no | yes |
BAP1_HUMAN | [view interactions] | High throughput | no | yes |
CLD4_HUMAN | [view interactions] | High throughput | no | yes |
RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TRI67_HUMAN | [view interactions] | High throughput | no | no |
GCSP_HUMAN | [view interactions] | High throughput | no | yes |
MIDN_HUMAN | [view interactions] | High throughput | no | no |
TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
KDM5C_HUMAN | [view interactions] | High throughput | no | no |
COR1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
EXOC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ILF2_HUMAN | [view interactions] | High throughput | no | yes |
CNDD3_HUMAN | [view interactions] | High throughput | no | no |
CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DYLT1_HUMAN | [view interactions] | High throughput | no | no |
DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
ANK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
CK052_HUMAN | [view interactions] | High throughput | no | no |
CAV1_HUMAN | [view interactions] | High throughput | no | no |
DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
ERGI1_HUMAN | [view interactions] | High throughput | no | yes |
FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CXD3_HUMAN | [view interactions] | High throughput | no | no |
LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
LAMP3_HUMAN | [view interactions] | High throughput | no | no |
LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LMAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OCLN_HUMAN | [view interactions] | High throughput | no | no |
RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
TMPS2_HUMAN | [view interactions] | High throughput | no | no |
RFA1_HUMAN | [view interactions] | High throughput | no | yes |
RFA2_HUMAN | [view interactions] | High throughput | no | yes |
RFA3_HUMAN | [view interactions] | High throughput | no | yes |
KCNQ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |