Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SPTN2_HUMAN

Probably plays an important role in neuronal membrane skeleton. [View more on UniProt]

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in SPTN2_HUMAN
GO:0043168 anion binding 40.7895 4 no
GO:0000166 nucleotide binding 39.4737 4 no
GO:0017076 purine nucleotide binding 39.4737 5 no
GO:0032555 purine ribonucleotide binding 39.4737 4 no
GO:0035639 purine ribonucleoside triphosphate binding 38.1579 4 no
GO:0019900 kinase binding 32.8947 4 no
GO:0019901 protein kinase binding 32.8947 5 no
GO:0003779 actin binding 22.3684 4 yes
GO:0005525 GTP binding 22.3684 5 no
GO:0019001 guanyl nucleotide binding 22.3684 6 no
GO:0032561 guanyl ribonucleotide binding 22.3684 5 no
GO:0043169 cation binding 21.0526 4 no
GO:0045296 cadherin binding 15.7895 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SPTN2_HUMAN
GO:0048522 positive regulation of cellular process 63.1579 4 no
GO:0051128 regulation of cellular component organization 59.2105 4 yes
GO:0048523 negative regulation of cellular process 51.3158 4 yes
GO:0006996 organelle organization 50.0000 4 yes
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0022607 cellular component assembly 47.3684 4 yes
GO:0060255 regulation of macromolecule metabolic process 47.3684 4 no
GO:0008104 protein localization 46.0526 4 no
GO:0009966 regulation of signal transduction 43.4211 4 no
GO:0080090 regulation of primary metabolic process 42.1053 4 no
GO:0031323 regulation of cellular metabolic process 40.7895 4 no
GO:0033043 regulation of organelle organization 38.1579 5 yes
GO:0009893 positive regulation of metabolic process 38.1579 4 no
GO:0010604 positive regulation of macromolecule metabolic process 38.1579 5 no
GO:0051246 regulation of protein metabolic process 36.8421 5 no
GO:0044087 regulation of cellular component biogenesis 35.5263 4 yes
GO:0030030 cell projection organization 35.5263 4 no
GO:0007010 cytoskeleton organization 34.2105 5 yes
GO:0009889 regulation of biosynthetic process 34.2105 4 no
GO:0010468 regulation of gene expression 34.2105 6 no
GO:0010556 regulation of macromolecule biosynthetic process 34.2105 5 no
GO:0010647 positive regulation of cell communication 34.2105 5 no
GO:0031326 regulation of cellular biosynthetic process 34.2105 5 no
GO:0048584 positive regulation of response to stimulus 34.2105 4 no
GO:0023056 positive regulation of signaling 32.8947 4 no
GO:0051493 regulation of cytoskeleton organization 31.5789 6 yes
GO:0009967 positive regulation of signal transduction 31.5789 5 no
GO:0031325 positive regulation of cellular metabolic process 30.2632 5 no
GO:1902531 regulation of intracellular signal transduction 30.2632 5 no
GO:0032970 regulation of actin filament-based process 28.9474 4 yes
GO:0031344 regulation of cell projection organization 28.9474 5 no
GO:0042981 regulation of apoptotic process 28.9474 5 no
GO:0043067 regulation of programmed cell death 28.9474 4 no
GO:0051130 positive regulation of cellular component organization 28.9474 5 no
GO:0051247 positive regulation of protein metabolic process 28.9474 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 28.9474 6 no
GO:0120036 plasma membrane bounded cell projection organization 28.9474 5 no
GO:0060341 regulation of cellular localization 27.6316 4 no
GO:0032956 regulation of actin cytoskeleton organization 26.3158 5 yes
GO:0051049 regulation of transport 26.3158 4 no
GO:0071702 organic substance transport 26.3158 4 no
GO:0032880 regulation of protein localization 26.3158 5 no
GO:0051129 negative regulation of cellular component organization 25.0000 5 yes
GO:1902903 regulation of supramolecular fiber organization 25.0000 5 yes
GO:0031399 regulation of protein modification process 25.0000 6 no
GO:0071705 nitrogen compound transport 25.0000 4 no
GO:0141124 intracellular signaling cassette 25.0000 4 no
GO:0019220 regulation of phosphate metabolic process 23.6842 6 no
GO:0042325 regulation of phosphorylation 23.6842 7 no
GO:0051174 regulation of phosphorus metabolic process 23.6842 5 no
GO:0034330 cell junction organization 22.3684 4 yes
GO:0110053 regulation of actin filament organization 22.3684 6 yes
GO:0001932 regulation of protein phosphorylation 22.3684 7 no
GO:0051240 positive regulation of multicellular organismal process 22.3684 4 no
GO:1902533 positive regulation of intracellular signal transduction 22.3684 6 no
GO:0006915 apoptotic process 21.0526 4 no
GO:0009892 negative regulation of metabolic process 21.0526 4 no
GO:0030155 regulation of cell adhesion 21.0526 4 no
GO:0022603 regulation of anatomical structure morphogenesis 21.0526 4 no
GO:0015031 protein transport 21.0526 4 no
GO:0043066 negative regulation of apoptotic process 21.0526 6 no
GO:0043069 negative regulation of programmed cell death 21.0526 5 no
GO:0043933 protein-containing complex organization 21.0526 4 no
GO:1903829 positive regulation of protein localization 21.0526 5 no
GO:0043254 regulation of protein-containing complex assembly 19.7368 5 yes
GO:0050808 synapse organization 17.1053 5 yes
GO:0032535 regulation of cellular component size 15.7895 4 yes
GO:0010639 negative regulation of organelle organization 14.4737 6 yes
GO:0032271 regulation of protein polymerization 13.1579 6 yes
GO:0034329 cell junction assembly 13.1579 5 yes
GO:0008064 regulation of actin polymerization or depolymerization 11.8421 6 yes
GO:0030832 regulation of actin filament length 11.8421 5 yes
GO:0051494 negative regulation of cytoskeleton organization 11.8421 7 yes
GO:1902904 negative regulation of supramolecular fiber organization 11.8421 6 yes
GO:0030833 regulation of actin filament polymerization 10.5263 7 yes
GO:0031333 negative regulation of protein-containing complex assembly 9.2105 6 yes
GO:0043244 regulation of protein-containing complex disassembly 9.2105 5 yes
GO:0043242 negative regulation of protein-containing complex disassembly 7.8947 6 yes
GO:1901879 regulation of protein depolymerization 7.8947 6 yes
GO:1901880 negative regulation of protein depolymerization 7.8947 7 yes
GO:0007416 synapse assembly 6.5789 6 yes
GO:0030834 regulation of actin filament depolymerization 6.5789 7 yes
GO:0030835 negative regulation of actin filament depolymerization 6.5789 7 yes
GO:0030837 negative regulation of actin filament polymerization 5.2632 7 yes
GO:0032272 negative regulation of protein polymerization 5.2632 7 yes
GO:0051693 actin filament capping 5.2632 8 yes
GO:1902115 regulation of organelle assembly 5.2632 5 yes
GO:0099150 regulation of postsynaptic specialization assembly 2.6316 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
UN13B_HUMAN [view interactions] Low throughput no no
ACTZ_HUMAN [view entry] [view interactions] Low throughput yes yes
AP2A2_HUMAN [view entry] [view interactions] Low throughput yes yes
SPTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
ACTB_HUMAN [view entry] [view interactions] Low throughput yes no
SPTN2_HUMAN [view entry] [view interactions] Low throughput yes yes
CELR3_HUMAN [view entry] [view interactions] High throughput yes no
AURKB_HUMAN [view interactions] High throughput no yes
MY18A_HUMAN [view entry] [view interactions] High throughput yes yes
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
MYO19_HUMAN [view interactions] High throughput no yes
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
BOD1_HUMAN [view interactions] High throughput no yes
CALL3_HUMAN [view interactions] High throughput no yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
ATAD2_HUMAN [view interactions] High throughput no no
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
IQGA1_HUMAN [view entry] [view interactions] High throughput yes no
ASF1A_HUMAN [view interactions] High throughput no no
PP1B_HUMAN [view entry] [view interactions] High throughput yes yes
SGTB_HUMAN [view interactions] High throughput no yes
SORT_HUMAN [view interactions] High throughput no yes
KSR1_HUMAN [view interactions] High throughput no yes
MOT11_HUMAN [view interactions] High throughput no no
MLH1_HUMAN [view interactions] High throughput no yes
SNF5_HUMAN [view interactions] High throughput no yes
CHK2_HUMAN [view interactions] High throughput no yes
NF2L2_HUMAN [view interactions] High throughput no yes
PK3CA_HUMAN [view entry] [view interactions] High throughput yes yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
TBB3_HUMAN [view entry] [view interactions] High throughput yes yes
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
SCRB2_HUMAN [view interactions] High throughput no yes
DAPK1_HUMAN [view entry] [view interactions] High throughput yes yes
TBCK_HUMAN [view interactions] High throughput no yes
HASP_HUMAN [view interactions] High throughput no yes
CNKR2_HUMAN [view entry] [view interactions] High throughput yes no
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
CYFP2_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
HOME1_HUMAN [view entry] [view interactions] High throughput yes yes
MYCB2_HUMAN [view entry] [view interactions] High throughput yes no
NCKP1_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
KALRN_HUMAN [view entry] [view interactions] High throughput yes yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
BMI1_HUMAN [view interactions] High throughput no yes
ANK2_HUMAN [view entry] [view interactions] High throughput yes yes
CK5P2_HUMAN [view interactions] High throughput no yes
CEP63_HUMAN [view interactions] High throughput no yes
APC_HUMAN [view entry] [view interactions] High throughput yes no
ADRB2_HUMAN [view entry] [view interactions] High throughput yes no
CDK1_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
STXB1_HUMAN [view entry] [view interactions] High throughput yes yes
PCNT_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
CTDSL_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
KCNK3_HUMAN [view interactions] High throughput no no
SIR7_HUMAN [view interactions] High throughput no yes
OBSL1_HUMAN [view interactions] High throughput no yes
CCDC8_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
UBE2A_HUMAN [view interactions] High throughput no no
CACO2_HUMAN [view interactions] High throughput no yes
RN123_HUMAN [view interactions] High throughput no yes
K1C17_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
UBP14_HUMAN [view entry] [view interactions] High throughput yes yes
APEX1_HUMAN [view interactions] High throughput no yes
RU17_HUMAN [view interactions] High throughput no yes
GRIA4_HUMAN [view entry] [view interactions] High throughput yes no
PINK1_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
TFCP2_HUMAN [view interactions] High throughput no no
ZCH18_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
ANLN_HUMAN [view interactions] High throughput no yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
CHM4C_HUMAN [view interactions] High throughput no yes
ECT2_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
PRC1_HUMAN [view interactions] High throughput no yes
AKT3_HUMAN [view interactions] High throughput no yes
NUDC2_HUMAN [view entry] [view interactions] High throughput yes yes
KIFA3_HUMAN [view entry] [view interactions] High throughput yes yes
SSUH2_HUMAN [view interactions] High throughput no no
MBNL1_HUMAN [view interactions] High throughput no yes
BHE23_HUMAN [view interactions] High throughput no no
NOLC1_HUMAN [view interactions] High throughput no yes
CC113_HUMAN [view interactions] High throughput no no
ABRA_HUMAN [view interactions] High throughput no no
CR021_HUMAN [view interactions] High throughput no no
NEMO_HUMAN [view interactions] High throughput no yes
CCR1_HUMAN [view interactions] High throughput no no
KGD4_HUMAN [view interactions] High throughput no yes
ZC3C1_HUMAN [view interactions] High throughput no yes
TOP3B_HUMAN [view interactions] High throughput no no
TFR1_HUMAN [view entry] [view interactions] High throughput yes yes
CATL1_HUMAN [view interactions] High throughput no yes
CATB_HUMAN [view interactions] High throughput no yes
IFM1_HUMAN [view interactions] High throughput no no
DPP4_HUMAN [view interactions] High throughput no no
IFM3_HUMAN [view interactions] High throughput no yes
CLC4D_HUMAN [view interactions] High throughput no no
CLC4E_HUMAN [view interactions] High throughput no no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND1_HUMAN [view interactions] High throughput no no
RND3_HUMAN [view interactions] High throughput no no
SOX2_HUMAN [view interactions] High throughput no yes
CALD1_HUMAN [view entry] [view interactions] High throughput yes no
ANM1_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC6_HUMAN [view interactions] High throughput no yes
UBP53_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
CLD4_HUMAN [view interactions] High throughput no yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
GCSP_HUMAN [view interactions] High throughput no yes
MIDN_HUMAN [view interactions] High throughput no no
TNIP1_HUMAN [view interactions] High throughput no yes
KDM5C_HUMAN [view interactions] High throughput no no
COR1B_HUMAN [view entry] [view interactions] High throughput yes no
EXOC2_HUMAN [view entry] [view interactions] High throughput yes no
ILF2_HUMAN [view interactions] High throughput no yes
CNDD3_HUMAN [view interactions] High throughput no no
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
DYLT1_HUMAN [view interactions] High throughput no no
DNJC5_HUMAN [view interactions] High throughput no yes
ANK3_HUMAN [view entry] [view interactions] High throughput yes yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
B3GA1_HUMAN [view interactions] High throughput no yes
CK052_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
DIRA3_HUMAN [view interactions] High throughput no yes
ERGI1_HUMAN [view interactions] High throughput no yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
CXD3_HUMAN [view interactions] High throughput no no
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP2_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LCK_HUMAN [view entry] [view interactions] High throughput yes no
LMAN1_HUMAN [view entry] [view interactions] High throughput yes yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
OCLN_HUMAN [view interactions] High throughput no no
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
ZFPL1_HUMAN [view interactions] High throughput no yes
TMPS2_HUMAN [view interactions] High throughput no no
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
KCNQ2_HUMAN [view entry] [view interactions] High throughput yes yes
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes