Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NCKP1_HUMAN

Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in NCKP1_HUMAN
GO:0019900 kinase binding 31.9588 4 no
GO:0003779 actin binding 31.9588 4 no
GO:0017076 purine nucleotide binding 29.8969 4 no
GO:0032555 purine ribonucleotide binding 29.8969 4 no
GO:0035639 purine ribonucleoside triphosphate binding 29.8969 4 no
GO:0019901 protein kinase binding 28.8660 5 no
GO:0005524 ATP binding 21.6495 5 no
GO:0030554 adenyl nucleotide binding 21.6495 5 no
GO:0032559 adenyl ribonucleotide binding 21.6495 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in NCKP1_HUMAN
GO:0048522 positive regulation of cellular process 63.9175 4 yes
GO:0051128 regulation of cellular component organization 63.9175 4 yes
GO:0010646 regulation of cell communication 55.6701 4 no
GO:0060255 regulation of macromolecule metabolic process 54.6392 4 no
GO:0031323 regulation of cellular metabolic process 51.5464 4 no
GO:0048523 negative regulation of cellular process 51.5464 4 no
GO:0051171 regulation of nitrogen compound metabolic process 50.5155 4 no
GO:0080090 regulation of primary metabolic process 50.5155 4 no
GO:0006996 organelle organization 49.4845 4 yes
GO:0009966 regulation of signal transduction 46.3918 4 no
GO:0022607 cellular component assembly 44.3299 4 yes
GO:0009893 positive regulation of metabolic process 42.2680 4 no
GO:0030030 cell projection organization 40.2062 4 yes
GO:0033043 regulation of organelle organization 40.2062 5 yes
GO:0044087 regulation of cellular component biogenesis 39.1753 4 yes
GO:0051130 positive regulation of cellular component organization 39.1753 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 39.1753 5 no
GO:0051246 regulation of protein metabolic process 39.1753 5 no
GO:0051493 regulation of cytoskeleton organization 38.1443 6 yes
GO:0031344 regulation of cell projection organization 37.1134 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 36.0825 6 yes
GO:0031325 positive regulation of cellular metabolic process 36.0825 5 no
GO:0051049 regulation of transport 36.0825 4 no
GO:0010468 regulation of gene expression 35.0515 5 no
GO:0019220 regulation of phosphate metabolic process 35.0515 6 no
GO:0031399 regulation of protein modification process 35.0515 6 no
GO:0051173 positive regulation of nitrogen compound metabolic process 35.0515 5 no
GO:0051174 regulation of phosphorus metabolic process 35.0515 5 no
GO:0007010 cytoskeleton organization 34.0206 5 yes
GO:0032956 regulation of actin cytoskeleton organization 32.9897 5 yes
GO:0032970 regulation of actin filament-based process 32.9897 4 yes
GO:0120036 plasma membrane bounded cell projection organization 32.9897 5 no
GO:0008104 protein localization 31.9588 4 no
GO:1902903 regulation of supramolecular fiber organization 30.9278 5 yes
GO:0009892 negative regulation of metabolic process 30.9278 4 no
GO:0042325 regulation of phosphorylation 30.9278 7 no
GO:1902531 regulation of intracellular signal transduction 30.9278 5 no
GO:0110053 regulation of actin filament organization 29.8969 6 yes
GO:0010605 negative regulation of macromolecule metabolic process 29.8969 5 no
GO:0050804 modulation of chemical synaptic transmission 28.8660 5 no
GO:0099177 regulation of trans-synaptic signaling 28.8660 4 no
GO:0001932 regulation of protein phosphorylation 27.8351 7 no
GO:0045595 regulation of cell differentiation 27.8351 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 27.8351 5 no
GO:0051247 positive regulation of protein metabolic process 27.8351 6 no
GO:0010647 positive regulation of cell communication 26.8041 5 no
GO:0023056 positive regulation of signaling 26.8041 4 no
GO:0048584 positive regulation of response to stimulus 26.8041 4 no
GO:0097435 supramolecular fiber organization 26.8041 4 no
GO:0022603 regulation of anatomical structure morphogenesis 26.8041 4 no
GO:0009889 regulation of biosynthetic process 25.7732 4 no
GO:0031324 negative regulation of cellular metabolic process 25.7732 5 no
GO:0031346 positive regulation of cell projection organization 24.7423 6 yes
GO:0044089 positive regulation of cellular component biogenesis 24.7423 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 24.7423 5 no
GO:0031326 regulation of cellular biosynthetic process 24.7423 5 no
GO:0051338 regulation of transferase activity 24.7423 4 no
GO:0051129 negative regulation of cellular component organization 24.7423 5 no
GO:0010638 positive regulation of organelle organization 23.7113 6 yes
GO:0010562 positive regulation of phosphorus metabolic process 23.7113 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 23.7113 5 no
GO:0036211 protein modification process 23.7113 4 no
GO:0042327 positive regulation of phosphorylation 23.7113 8 no
GO:0043412 macromolecule modification 23.7113 4 no
GO:0045937 positive regulation of phosphate metabolic process 23.7113 7 no
GO:0010975 regulation of neuron projection development 23.7113 7 no
GO:0007015 actin filament organization 23.7113 5 no
GO:0071310 cellular response to organic substance 23.7113 4 no
GO:0043254 regulation of protein-containing complex assembly 22.6804 5 yes
GO:0006796 phosphate-containing compound metabolic process 22.6804 4 no
GO:0043085 positive regulation of catalytic activity 22.6804 4 no
GO:0051248 negative regulation of protein metabolic process 22.6804 6 no
GO:0051094 positive regulation of developmental process 22.6804 4 no
GO:0016192 vesicle-mediated transport 22.6804 4 no
GO:0034330 cell junction organization 22.6804 4 no
GO:0031401 positive regulation of protein modification process 21.6495 7 no
GO:0043549 regulation of kinase activity 21.6495 5 no
GO:0051050 positive regulation of transport 21.6495 4 no
GO:0032535 regulation of cellular component size 20.6186 4 yes
GO:0051495 positive regulation of cytoskeleton organization 20.6186 7 yes
GO:1902905 positive regulation of supramolecular fiber organization 20.6186 6 yes
GO:0051252 regulation of RNA metabolic process 20.6186 5 no
GO:0009967 positive regulation of signal transduction 20.6186 5 no
GO:0010941 regulation of cell death 20.6186 4 no
GO:0080134 regulation of response to stress 20.6186 4 no
GO:0031175 neuron projection development 20.6186 6 no
GO:0010243 response to organonitrogen compound 20.6186 4 no
GO:0032990 cell part morphogenesis 19.5876 4 yes
GO:0048858 cell projection morphogenesis 19.5876 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 19.5876 6 yes
GO:0030031 cell projection assembly 18.5567 5 yes
GO:0032271 regulation of protein polymerization 18.5567 6 yes
GO:0048812 neuron projection morphogenesis 17.5258 7 yes
GO:0008064 regulation of actin polymerization or depolymerization 15.4639 6 yes
GO:0030832 regulation of actin filament length 15.4639 5 yes
GO:0030833 regulation of actin filament polymerization 15.4639 7 yes
GO:0060491 regulation of cell projection assembly 15.4639 5 yes
GO:0120032 regulation of plasma membrane bounded cell projection assembly 15.4639 6 yes
GO:0007264 small GTPase mediated signal transduction 13.4021 4 yes
GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 13.4021 6 yes
GO:0007265 Ras protein signal transduction 11.3402 5 yes
GO:0031334 positive regulation of protein-containing complex assembly 11.3402 6 yes
GO:0006915 apoptotic process 10.3093 4 yes
GO:0010591 regulation of lamellipodium assembly 10.3093 7 yes
GO:0010592 positive regulation of lamellipodium assembly 10.3093 7 yes
GO:0032273 positive regulation of protein polymerization 10.3093 7 yes
GO:1902743 regulation of lamellipodium organization 10.3093 7 yes
GO:1902745 positive regulation of lamellipodium organization 10.3093 7 yes
GO:0030865 cortical cytoskeleton organization 9.2784 6 yes
GO:0030838 positive regulation of actin filament polymerization 8.2474 7 yes
GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation 8.2474 8 yes
GO:0051125 regulation of actin nucleation 8.2474 7 yes
GO:0016601 Rac protein signal transduction 7.2165 6 yes
GO:0051127 positive regulation of actin nucleation 7.2165 7 yes
GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation 7.2165 8 yes
GO:0030866 cortical actin cytoskeleton organization 5.1546 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in NCKP1_HUMAN
DOID:114 heart disease 3.0928 3 no
DOID:0050700 cardiomyopathy 2.0619 4 no
DOID:0060036 intrinsic cardiomyopathy 2.0619 5 no
DOID:2843 long QT syndrome 2.0619 6 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CYFP1_HUMAN [view entry] [view interactions] Low throughput yes yes
NYAP1_HUMAN [view interactions] Low throughput no no
MYO16_HUMAN [view interactions] Low throughput no no
ABI1_HUMAN [view entry] [view interactions] Low throughput yes yes
WASF2_HUMAN [view entry] [view interactions] Low throughput yes yes
CYFP2_HUMAN [view entry] [view interactions] Low throughput yes yes
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
BRK1_HUMAN [view interactions] Low throughput no no
WASF1_HUMAN [view entry] [view interactions] Low throughput yes yes
NYAP2_HUMAN [view interactions] Low throughput no no
ABI2_HUMAN [view entry] [view interactions] Low throughput yes yes
DPYL1_HUMAN [view entry] [view interactions] High throughput yes yes
SYN1_HUMAN [view entry] [view interactions] High throughput yes no
SYN2_HUMAN [view entry] [view interactions] High throughput yes no
WIPF2_HUMAN [view entry] [view interactions] High throughput yes yes
ACTC_HUMAN [view interactions] High throughput no no
GBF1_HUMAN [view interactions] High throughput no yes
BICD1_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
HOOK1_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
TOLIP_HUMAN [view entry] [view interactions] High throughput yes yes
GLUT4_HUMAN [view interactions] High throughput no no
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
HAKAI_HUMAN [view interactions] High throughput no yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
NHSL1_HUMAN [view interactions] High throughput no yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
LRRK2_HUMAN [view interactions] High throughput no yes
RIN3_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
GAS7_HUMAN [view entry] [view interactions] High throughput yes yes
P85A_HUMAN [view interactions] High throughput no yes
PCD10_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
STK16_HUMAN [view interactions] High throughput no no
SIK1_HUMAN [view interactions] High throughput no yes
STK38_HUMAN [view entry] [view interactions] High throughput yes yes
SGK3_HUMAN [view interactions] High throughput no yes
AURKB_HUMAN [view interactions] High throughput no yes
M3K2_HUMAN [view interactions] High throughput no yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
SNP25_HUMAN [view entry] [view interactions] High throughput yes yes
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
DMXL2_HUMAN [view entry] [view interactions] High throughput yes yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
SPTN2_HUMAN [view entry] [view interactions] High throughput yes yes
SPTB2_HUMAN [view entry] [view interactions] High throughput yes yes
SPTN1_HUMAN [view entry] [view interactions] High throughput yes yes
SGIP1_HUMAN [view entry] [view interactions] High throughput yes yes
NFM_HUMAN [view entry] [view interactions] High throughput yes yes
NFL_HUMAN [view entry] [view interactions] High throughput yes yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
E41L3_HUMAN [view entry] [view interactions] High throughput yes yes
E41L1_HUMAN [view entry] [view interactions] High throughput yes yes
DPYL2_HUMAN [view entry] [view interactions] High throughput yes yes
DYN1_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
BAIP2_HUMAN [view entry] [view interactions] High throughput yes yes
AP2A1_HUMAN [view entry] [view interactions] High throughput yes yes
PEX5R_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
ITF2_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
CE128_HUMAN [view interactions] High throughput no yes
CE152_HUMAN [view interactions] High throughput no yes
TMM17_HUMAN [view interactions] High throughput no yes
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
LAMP1_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
EPHA4_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA7_HUMAN [view entry] [view interactions] High throughput yes no
EPHB2_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR1_HUMAN [view interactions] High throughput no yes
ROR2_HUMAN [view entry] [view interactions] High throughput yes yes
NXN_HUMAN [view interactions] High throughput no no
CAD23_HUMAN [view interactions] High throughput no yes
OSTP_HUMAN [view interactions] High throughput no yes
DNMBP_HUMAN [view interactions] High throughput no no
RYK_HUMAN [view interactions] High throughput no no
PROF2_HUMAN [view entry] [view interactions] High throughput yes yes
SIR7_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
HUWE1_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
ZN511_HUMAN [view interactions] High throughput no yes
UBX11_HUMAN [view interactions] High throughput no yes
DTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
NCK2_HUMAN [view entry] [view interactions] High throughput yes yes
HSPB9_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
ABCG1_HUMAN [view interactions] High throughput no yes
CAF1A_HUMAN [view interactions] High throughput no yes
ZN746_HUMAN [view interactions] High throughput no no
AMZ1_HUMAN [view interactions] High throughput no no
IKIP_HUMAN [view interactions] High throughput no no
TIM50_HUMAN [view entry] [view interactions] High throughput yes yes
WASF3_HUMAN [view entry] [view interactions] High throughput yes yes
CBLC_HUMAN [view interactions] High throughput no yes
GRRE1_HUMAN [view interactions] High throughput no no
PAAT_HUMAN [view interactions] High throughput no yes
HOME3_HUMAN [view entry] [view interactions] High throughput yes yes
COG6_HUMAN [view interactions] High throughput no yes
CXB7_HUMAN [view interactions] High throughput no no
U5S1_HUMAN [view interactions] High throughput no yes
PIHD1_HUMAN [view interactions] High throughput no yes
RNF4_HUMAN [view interactions] High throughput no yes
LARP7_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
ATX3_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
LMBRL_HUMAN [view interactions] High throughput no no
WWP2_HUMAN [view interactions] High throughput no no
TIF1B_HUMAN [view interactions] High throughput no yes
CUL9_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
AKT3_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
CSN5_HUMAN [view interactions] High throughput no yes
CUL4A_HUMAN [view interactions] High throughput no no
WDR5_HUMAN [view interactions] High throughput no no
FGOP2_HUMAN [view interactions] High throughput no yes
NCK1_HUMAN [view interactions] High throughput no yes
RHG12_HUMAN [view interactions] High throughput no yes
NHS_HUMAN [view interactions] High throughput no yes
MPPD2_HUMAN [view interactions] High throughput no no
K1522_HUMAN [view interactions] High throughput no yes
ES8L1_HUMAN [view interactions] High throughput no no
SPTCS_HUMAN [view interactions] High throughput no yes
LHX4_HUMAN [view interactions] High throughput no no
GP182_HUMAN [view interactions] High throughput no no
SGF29_HUMAN [view interactions] High throughput no yes
FBX32_HUMAN [view interactions] High throughput no no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
KC1G3_HUMAN [view interactions] High throughput no yes
ADNP2_HUMAN [view interactions] High throughput no yes
H2A2A_HUMAN [view interactions] High throughput no yes
HOME1_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
H2B1C_HUMAN [view interactions] High throughput no yes
H1X_HUMAN [view interactions] High throughput no yes
MECR_HUMAN [view entry] [view interactions] High throughput yes yes
TTC28_HUMAN [view interactions] High throughput no no
ENAH_HUMAN [view entry] [view interactions] High throughput yes yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
H2AZ_HUMAN [view interactions] High throughput no yes
P4HA1_HUMAN [view interactions] High throughput no yes
MYL6B_HUMAN [view entry] [view interactions] High throughput yes no
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
ABL2_HUMAN [view entry] [view interactions] High throughput yes yes
ABL1_HUMAN [view entry] [view interactions] High throughput yes yes
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
PP2AA_HUMAN [view entry] [view interactions] High throughput yes yes
PSMD6_HUMAN [view interactions] High throughput no yes
ACTS_HUMAN [view interactions] High throughput no no
CAP2_HUMAN [view entry] [view interactions] High throughput yes yes
CLU_HUMAN [view interactions] High throughput no yes
MCM4_HUMAN [view interactions] High throughput no yes
ERF1_HUMAN [view interactions] High throughput no yes
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
PPM1A_HUMAN [view interactions] High throughput no yes
PPM1B_HUMAN [view interactions] High throughput no yes
ARPC2_HUMAN [view entry] [view interactions] Computational yes yes
NCKPL_HUMAN [view entry] [view interactions] Computational yes yes
ARF1_HUMAN [view entry] [view interactions] Computational yes yes
WASL_HUMAN [view entry] [view interactions] Computational yes yes
ARP2_HUMAN [view entry] [view interactions] Computational yes yes
PIR_HUMAN [view interactions] Computational no no
MK03_HUMAN [view entry] [view interactions] Computational yes yes
SRA1_HUMAN [view interactions] Computational no yes
ARP3_HUMAN [view entry] [view interactions] Computational yes yes
ARC1B_HUMAN [view interactions] Computational no no
PSA7_HUMAN [view interactions] Computational no yes
ARPC4_HUMAN [view entry] [view interactions] Computational yes no
ARPC3_HUMAN [view entry] [view interactions] Computational yes yes
MK01_HUMAN [view entry] [view interactions] Computational yes yes
DIAP3_HUMAN [view interactions] Computational no no
CDC42_HUMAN [view entry] [view interactions] Computational yes yes
ARPC5_HUMAN [view interactions] Computational no yes
WASP_HUMAN [view interactions] Computational no yes