Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NCKP1_HUMAN

Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in NCKP1_HUMAN
GO:0000166 nucleotide binding 31.1321 4 no
GO:0017076 purine nucleotide binding 31.1321 5 no
GO:0043168 anion binding 31.1321 4 no
GO:0019900 kinase binding 31.1321 4 no
GO:0032555 purine ribonucleotide binding 30.1887 4 no
GO:0035639 purine ribonucleoside triphosphate binding 30.1887 4 no
GO:0019901 protein kinase binding 27.3585 5 no
GO:0030554 adenyl nucleotide binding 25.4717 6 no
GO:0003779 actin binding 25.4717 4 no
GO:0005524 ATP binding 24.5283 5 no
GO:0032559 adenyl ribonucleotide binding 24.5283 5 no
GO:0043169 cation binding 20.7547 4 no
GO:0046872 metal ion binding 20.7547 5 no
GO:0003723 RNA binding 20.7547 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in NCKP1_HUMAN
GO:0048522 positive regulation of cellular process 63.2075 4 yes
GO:0051128 regulation of cellular component organization 56.6038 4 yes
GO:0048523 negative regulation of cellular process 55.6604 4 no
GO:0010646 regulation of cell communication 54.7170 4 no
GO:0031323 regulation of cellular metabolic process 54.7170 4 no
GO:0060255 regulation of macromolecule metabolic process 53.7736 4 no
GO:0080090 regulation of primary metabolic process 47.1698 4 no
GO:0009966 regulation of signal transduction 46.2264 4 no
GO:0006996 organelle organization 43.3962 4 yes
GO:0022607 cellular component assembly 41.5094 4 yes
GO:0051246 regulation of protein metabolic process 38.6792 5 no
GO:0009893 positive regulation of metabolic process 37.7358 4 no
GO:0010604 positive regulation of macromolecule metabolic process 36.7925 5 no
GO:0009889 regulation of biosynthetic process 36.7925 4 no
GO:0010556 regulation of macromolecule biosynthetic process 36.7925 5 no
GO:0031326 regulation of cellular biosynthetic process 36.7925 5 no
GO:0030030 cell projection organization 35.8491 4 yes
GO:0031325 positive regulation of cellular metabolic process 34.9057 5 no
GO:1902531 regulation of intracellular signal transduction 34.9057 5 no
GO:0010468 regulation of gene expression 34.9057 6 no
GO:0031399 regulation of protein modification process 33.9623 6 no
GO:0033043 regulation of organelle organization 33.0189 5 yes
GO:0044087 regulation of cellular component biogenesis 33.0189 4 yes
GO:0051130 positive regulation of cellular component organization 33.0189 5 yes
GO:0019220 regulation of phosphate metabolic process 33.0189 6 no
GO:0051174 regulation of phosphorus metabolic process 33.0189 5 no
GO:0009892 negative regulation of metabolic process 33.0189 4 no
GO:0008104 protein localization 32.0755 4 no
GO:0010605 negative regulation of macromolecule metabolic process 32.0755 5 no
GO:0031324 negative regulation of cellular metabolic process 32.0755 5 no
GO:0051049 regulation of transport 32.0755 4 no
GO:0031344 regulation of cell projection organization 31.1321 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 30.1887 6 yes
GO:0051493 regulation of cytoskeleton organization 29.2453 6 yes
GO:0051247 positive regulation of protein metabolic process 29.2453 6 no
GO:0007010 cytoskeleton organization 29.2453 5 yes
GO:0042325 regulation of phosphorylation 28.3019 7 no
GO:0048584 positive regulation of response to stimulus 28.3019 4 no
GO:0001932 regulation of protein phosphorylation 27.3585 7 no
GO:0120036 plasma membrane bounded cell projection organization 27.3585 5 no
GO:0032956 regulation of actin cytoskeleton organization 26.4151 5 yes
GO:0032970 regulation of actin filament-based process 26.4151 4 yes
GO:0010647 positive regulation of cell communication 26.4151 5 no
GO:0023056 positive regulation of signaling 26.4151 4 no
GO:1902903 regulation of supramolecular fiber organization 25.4717 5 yes
GO:0050804 modulation of chemical synaptic transmission 25.4717 5 no
GO:0099177 regulation of trans-synaptic signaling 25.4717 4 no
GO:0022603 regulation of anatomical structure morphogenesis 24.5283 4 no
GO:0031401 positive regulation of protein modification process 24.5283 7 no
GO:0051129 negative regulation of cellular component organization 24.5283 5 no
GO:0110053 regulation of actin filament organization 23.5849 6 yes
GO:0141124 intracellular signaling cassette 23.5849 4 yes
GO:0045595 regulation of cell differentiation 23.5849 4 no
GO:0010975 regulation of neuron projection development 22.6415 7 no
GO:0009890 negative regulation of biosynthetic process 22.6415 5 no
GO:0006796 phosphate-containing compound metabolic process 21.6981 4 no
GO:0009967 positive regulation of signal transduction 21.6981 5 no
GO:0051240 positive regulation of multicellular organismal process 21.6981 4 no
GO:0071310 cellular response to organic substance 21.6981 4 no
GO:0097435 supramolecular fiber organization 21.6981 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 21.6981 6 no
GO:0031327 negative regulation of cellular biosynthetic process 21.6981 6 no
GO:0034330 cell junction organization 21.6981 4 no
GO:0044089 positive regulation of cellular component biogenesis 20.7547 5 yes
GO:0010562 positive regulation of phosphorus metabolic process 20.7547 6 no
GO:0036211 protein modification process 20.7547 4 no
GO:0042327 positive regulation of phosphorylation 20.7547 8 no
GO:0043412 macromolecule modification 20.7547 4 no
GO:0045937 positive regulation of phosphate metabolic process 20.7547 7 no
GO:0051050 positive regulation of transport 20.7547 4 no
GO:0051248 negative regulation of protein metabolic process 20.7547 6 no
GO:0031346 positive regulation of cell projection organization 18.8679 6 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 18.8679 4 yes
GO:0032535 regulation of cellular component size 17.9245 4 yes
GO:0043254 regulation of protein-containing complex assembly 17.9245 5 yes
GO:0010638 positive regulation of organelle organization 17.9245 6 yes
GO:0048812 neuron projection morphogenesis 16.9811 5 yes
GO:0051495 positive regulation of cytoskeleton organization 16.0377 7 yes
GO:1902905 positive regulation of supramolecular fiber organization 16.0377 6 yes
GO:0030031 cell projection assembly 14.1509 5 yes
GO:0007264 small GTPase-mediated signal transduction 13.2075 5 yes
GO:0032271 regulation of protein polymerization 12.2642 6 yes
GO:0006915 apoptotic process 12.2642 4 yes
GO:0030832 regulation of actin filament length 10.3774 5 yes
GO:0031334 positive regulation of protein-containing complex assembly 10.3774 6 yes
GO:0008064 regulation of actin polymerization or depolymerization 10.3774 6 yes
GO:0030833 regulation of actin filament polymerization 9.4340 7 yes
GO:0060491 regulation of cell projection assembly 9.4340 5 yes
GO:0120032 regulation of plasma membrane bounded cell projection assembly 9.4340 6 yes
GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 7.5472 6 yes
GO:0016601 Rac protein signal transduction 7.5472 6 yes
GO:0030865 cortical cytoskeleton organization 6.6038 6 yes
GO:0032273 positive regulation of protein polymerization 6.6038 7 yes
GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation 5.6604 8 yes
GO:0051125 regulation of actin nucleation 5.6604 7 yes
GO:0051127 positive regulation of actin nucleation 5.6604 7 yes
GO:1902743 regulation of lamellipodium organization 5.6604 7 yes
GO:1902745 positive regulation of lamellipodium organization 5.6604 7 yes
GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation 5.6604 8 yes
GO:0010591 regulation of lamellipodium assembly 5.6604 7 yes
GO:0010592 positive regulation of lamellipodium assembly 5.6604 7 yes
GO:0030838 positive regulation of actin filament polymerization 4.7170 7 yes
GO:0030866 cortical actin cytoskeleton organization 4.7170 4 yes
GO:0007417 central nervous system development 2.8302 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CYFP1_HUMAN [view entry] [view interactions] Low throughput yes yes
NYAP1_HUMAN [view interactions] Low throughput no no
MYO16_HUMAN [view interactions] Low throughput no no
ABI1_HUMAN [view entry] [view interactions] Low throughput yes yes
WASF2_HUMAN [view entry] [view interactions] Low throughput yes yes
CYFP2_HUMAN [view entry] [view interactions] Low throughput yes yes
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
BRK1_HUMAN [view interactions] Low throughput no no
WASF1_HUMAN [view entry] [view interactions] Low throughput yes yes
NYAP2_HUMAN [view interactions] Low throughput no no
ABI2_HUMAN [view entry] [view interactions] Low throughput yes yes
SYN2_HUMAN [view entry] [view interactions] High throughput yes no
WIPF2_HUMAN [view entry] [view interactions] High throughput yes yes
ROCK2_HUMAN [view entry] [view interactions] High throughput yes yes
ATG7_HUMAN [view interactions] High throughput no yes
PRS6A_HUMAN [view entry] [view interactions] High throughput yes yes
PRS7_HUMAN [view interactions] High throughput no yes
PURA_HUMAN [view entry] [view interactions] High throughput yes no
IF4G1_HUMAN [view entry] [view interactions] High throughput yes yes
SFSWA_HUMAN [view interactions] High throughput no yes
ACACA_HUMAN [view entry] [view interactions] High throughput yes yes
DPOA2_HUMAN [view interactions] High throughput no yes
PDCD4_HUMAN [view interactions] High throughput no yes
CCAR2_HUMAN [view interactions] High throughput no yes
HS105_HUMAN [view entry] [view interactions] High throughput yes yes
DBLOH_HUMAN [view interactions] High throughput no no
STK26_HUMAN [view interactions] High throughput no no
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
BIG1_HUMAN [view interactions] High throughput no yes
ACTC_HUMAN [view interactions] High throughput no no
GBF1_HUMAN [view interactions] High throughput no yes
BICD1_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
HOOK1_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
TOLIP_HUMAN [view entry] [view interactions] High throughput yes yes
TAOK2_HUMAN [view entry] [view interactions] High throughput yes yes
CCNF_HUMAN [view interactions] High throughput no no
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
GLUT4_HUMAN [view interactions] High throughput no no
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
HAKAI_HUMAN [view interactions] High throughput no yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
NHSL1_HUMAN [view interactions] High throughput no yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
LRRK2_HUMAN [view interactions] High throughput no yes
RIN3_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
GAS7_HUMAN [view entry] [view interactions] High throughput yes yes
P85A_HUMAN [view interactions] High throughput no yes
PCD10_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
STK16_HUMAN [view interactions] High throughput no no
SIK1_HUMAN [view interactions] High throughput no yes
STK38_HUMAN [view entry] [view interactions] High throughput yes yes
SGK3_HUMAN [view interactions] High throughput no yes
AURKB_HUMAN [view interactions] High throughput no yes
M3K2_HUMAN [view interactions] High throughput no yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
SNP25_HUMAN [view entry] [view interactions] High throughput yes yes
DMXL2_HUMAN [view entry] [view interactions] High throughput yes yes
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
AP2A1_HUMAN [view entry] [view interactions] High throughput yes yes
BAIP2_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
DYN1_HUMAN [view entry] [view interactions] High throughput yes yes
DPYL2_HUMAN [view entry] [view interactions] High throughput yes yes
E41L1_HUMAN [view entry] [view interactions] High throughput yes yes
E41L3_HUMAN [view entry] [view interactions] High throughput yes yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
NFL_HUMAN [view entry] [view interactions] High throughput yes yes
NFM_HUMAN [view entry] [view interactions] High throughput yes yes
SGIP1_HUMAN [view entry] [view interactions] High throughput yes yes
SPTN1_HUMAN [view entry] [view interactions] High throughput yes yes
SPTB2_HUMAN [view entry] [view interactions] High throughput yes yes
SPTN2_HUMAN [view entry] [view interactions] High throughput yes yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
PEX5R_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
SCN2A_HUMAN [view entry] [view interactions] High throughput yes yes
CE192_HUMAN [view interactions] High throughput no yes
ITF2_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
CE128_HUMAN [view interactions] High throughput no yes
CE152_HUMAN [view interactions] High throughput no yes
TMM17_HUMAN [view interactions] High throughput no yes
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
EPHA4_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA7_HUMAN [view entry] [view interactions] High throughput yes no
EPHB2_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes
ROR2_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
NXN_HUMAN [view interactions] High throughput no no
CAD23_HUMAN [view interactions] High throughput no yes
OSTP_HUMAN [view interactions] High throughput no yes
DNMBP_HUMAN [view interactions] High throughput no no
RYK_HUMAN [view entry] [view interactions] High throughput yes no
PROF2_HUMAN [view entry] [view interactions] High throughput yes yes
SIR7_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
HUWE1_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
ZN511_HUMAN [view interactions] High throughput no yes
UBX11_HUMAN [view interactions] High throughput no yes
DTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
NCK2_HUMAN [view entry] [view interactions] High throughput yes yes
HSPB9_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
ABCG1_HUMAN [view interactions] High throughput no yes
CAF1A_HUMAN [view interactions] High throughput no yes
ZN746_HUMAN [view interactions] High throughput no no
AMZ1_HUMAN [view interactions] High throughput no no
IKIP_HUMAN [view interactions] High throughput no no
TIM50_HUMAN [view entry] [view interactions] High throughput yes yes
WASF3_HUMAN [view entry] [view interactions] High throughput yes yes
CBLC_HUMAN [view interactions] High throughput no yes
GRRE1_HUMAN [view interactions] High throughput no no
PAAT_HUMAN [view interactions] High throughput no yes
HOME3_HUMAN [view entry] [view interactions] High throughput yes yes
COG6_HUMAN [view interactions] High throughput no yes
CXB7_HUMAN [view interactions] High throughput no no
U5S1_HUMAN [view interactions] High throughput no yes
PIHD1_HUMAN [view interactions] High throughput no yes
RNF4_HUMAN [view interactions] High throughput no yes
LARP7_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
ATX3_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
LMBRL_HUMAN [view interactions] High throughput no no
WWP2_HUMAN [view interactions] High throughput no no
TIF1B_HUMAN [view interactions] High throughput no yes
CUL9_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
AKT3_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
CSN5_HUMAN [view interactions] High throughput no yes
CUL4A_HUMAN [view interactions] High throughput no no
WDR5_HUMAN [view interactions] High throughput no no
FGOP2_HUMAN [view interactions] High throughput no yes
NCK1_HUMAN [view interactions] High throughput no yes
RHG12_HUMAN [view entry] [view interactions] High throughput yes yes
NHS_HUMAN [view interactions] High throughput no yes
MPPD2_HUMAN [view interactions] High throughput no no
NHSL3_HUMAN [view interactions] High throughput no yes
ES8L1_HUMAN [view interactions] High throughput no no
SPTCS_HUMAN [view interactions] High throughput no yes
LHX4_HUMAN [view interactions] High throughput no no
GP182_HUMAN [view interactions] High throughput no no
SGF29_HUMAN [view interactions] High throughput no yes
FBX32_HUMAN [view interactions] High throughput no no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
KC1G3_HUMAN [view interactions] High throughput no yes
ADNP2_HUMAN [view interactions] High throughput no yes
H2A2A_HUMAN [view interactions] High throughput no yes
HOME1_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
H2B1C_HUMAN [view interactions] High throughput no yes
H1X_HUMAN [view interactions] High throughput no yes
MECR_HUMAN [view entry] [view interactions] High throughput yes yes
TTC28_HUMAN [view interactions] High throughput no no
ENAH_HUMAN [view entry] [view interactions] High throughput yes yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
H2AZ_HUMAN [view interactions] High throughput no yes
P4HA1_HUMAN [view interactions] High throughput no yes
MYL6B_HUMAN [view entry] [view interactions] High throughput yes no
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
ABL2_HUMAN [view entry] [view interactions] High throughput yes yes
ABL1_HUMAN [view entry] [view interactions] High throughput yes yes
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
PP2AA_HUMAN [view entry] [view interactions] High throughput yes yes
PSMD6_HUMAN [view interactions] High throughput no yes
TLS1_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC6_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
PARPT_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
RHG24_HUMAN [view interactions] High throughput no yes
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
MET14_HUMAN [view interactions] High throughput no yes
EZH2_HUMAN [view interactions] High throughput no no
UBE2H_HUMAN [view interactions] High throughput no yes
ACTS_HUMAN [view interactions] High throughput no no
CAP2_HUMAN [view entry] [view interactions] High throughput yes yes
CLU_HUMAN [view interactions] High throughput no yes
MCM4_HUMAN [view interactions] High throughput no yes
ERF1_HUMAN [view interactions] High throughput no yes
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
PPM1A_HUMAN [view interactions] High throughput no yes
PPM1B_HUMAN [view interactions] High throughput no yes
DPYL1_HUMAN [view entry] [view interactions] High throughput yes yes
SYN1_HUMAN [view entry] [view interactions] High throughput yes no