Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PEX5R_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PEX5R_HUMAN
GO:0045296 cadherin binding 25.0000 4 no
GO:0008324 cation transmembrane transporter activity 12.5000 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 12.5000 4 yes
GO:0051020 GTPase binding 12.5000 4 yes
GO:0005216 ion channel activity 10.0000 4 yes
GO:0005261 cation channel activity 10.0000 5 yes
GO:0015267 channel activity 10.0000 4 yes
GO:0031267 small GTPase binding 10.0000 5 yes
GO:0005217 intracellular ligand-gated ion channel activity 7.5000 6 yes
GO:0005221 intracellular cyclic nucleotide activated cation channel activity 7.5000 7 yes
GO:0015276 ligand-gated ion channel activity 7.5000 5 yes
GO:0022834 ligand-gated channel activity 7.5000 6 yes
GO:0022836 gated channel activity 7.5000 5 yes
GO:0043855 cyclic nucleotide-gated ion channel activity 7.5000 6 yes
GO:0099094 ligand-gated cation channel activity 7.5000 6 yes
GO:0005048 signal sequence binding 5.0000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PEX5R_HUMAN
GO:0051128 regulation of cellular component organization 47.5000 4 no
GO:0048522 positive regulation of cellular process 47.5000 4 no
GO:0010646 regulation of cell communication 45.0000 4 yes
GO:0008104 protein localization 37.5000 4 yes
GO:0048523 negative regulation of cellular process 35.0000 4 no
GO:0022607 cellular component assembly 35.0000 4 no
GO:0009966 regulation of signal transduction 30.0000 4 yes
GO:0006996 organelle organization 27.5000 4 no
GO:0033043 regulation of organelle organization 27.5000 5 no
GO:0060255 regulation of macromolecule metabolic process 27.5000 4 no
GO:0071702 organic substance transport 25.0000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 25.0000 4 no
GO:0080090 regulation of primary metabolic process 25.0000 4 no
GO:0032970 regulation of actin filament-based process 22.5000 4 no
GO:0051493 regulation of cytoskeleton organization 22.5000 6 no
GO:1902903 regulation of supramolecular fiber organization 22.5000 5 no
GO:0009893 positive regulation of metabolic process 22.5000 4 no
GO:0015031 protein transport 22.5000 4 no
GO:0016192 vesicle-mediated transport 22.5000 4 no
GO:0034330 cell junction organization 22.5000 4 no
GO:0051049 regulation of transport 22.5000 4 no
GO:0071705 nitrogen compound transport 22.5000 4 no
GO:0071310 cellular response to organic substance 22.5000 4 no
GO:1901701 cellular response to oxygen-containing compound 22.5000 4 no
GO:0031344 regulation of cell projection organization 22.5000 5 no
GO:1902531 regulation of intracellular signal transduction 12.5000 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in PEX5R_HUMAN
DOID:331 central nervous system disease 5.0000 3 no
DOID:936 brain disease 5.0000 4 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PEX14_HUMAN [view interactions] Low throughput no yes
HCN1_HUMAN [view entry] [view interactions] Low throughput yes yes
HCN3_HUMAN [view interactions] Low throughput no yes
HCN2_HUMAN [view entry] [view interactions] Low throughput yes no
PEX7_HUMAN [view interactions] Low throughput no yes
TNKS1_HUMAN [view interactions] High throughput no yes
K1C18_HUMAN [view interactions] High throughput no no
K2C8_HUMAN [view interactions] High throughput no no
VIME_HUMAN [view entry] [view interactions] High throughput yes no
RS25_HUMAN [view entry] [view interactions] High throughput yes yes
CYFP2_HUMAN [view entry] [view interactions] High throughput yes yes
AGO2_HUMAN [view interactions] High throughput no yes
WDR7_HUMAN [view entry] [view interactions] High throughput yes no
UN13A_HUMAN [view entry] [view interactions] High throughput yes no
TENR_HUMAN [view entry] [view interactions] High throughput yes no
TANC2_HUMAN [view entry] [view interactions] High throughput yes yes
SPTB2_HUMAN [view entry] [view interactions] High throughput yes yes
SPTN1_HUMAN [view entry] [view interactions] High throughput yes yes
S4A4_HUMAN [view entry] [view interactions] High throughput yes no
S12A5_HUMAN [view entry] [view interactions] High throughput yes yes
SKT_HUMAN [view entry] [view interactions] High throughput yes yes
PPR3F_HUMAN [view interactions] High throughput no yes
PEX5_HUMAN [view interactions] High throughput no yes
PARD3_HUMAN [view interactions] High throughput no yes
NCKP1_HUMAN [view entry] [view interactions] High throughput yes yes
NCAN_HUMAN [view entry] [view interactions] High throughput yes no
MYO5A_HUMAN [view entry] [view interactions] High throughput yes yes
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
KCD16_HUMAN [view entry] [view interactions] High throughput yes yes
ICAM5_HUMAN [view entry] [view interactions] High throughput yes yes
HCN4_HUMAN [view interactions] High throughput no yes
GIT1_HUMAN [view entry] [view interactions] High throughput yes yes
GABR2_HUMAN [view entry] [view interactions] High throughput yes yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
CTND2_HUMAN [view entry] [view interactions] High throughput yes no
CTNA1_HUMAN [view entry] [view interactions] High throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
CTNA2_HUMAN [view entry] [view interactions] High throughput yes yes
CADH2_HUMAN [view entry] [view interactions] High throughput yes no
CAD11_HUMAN [view interactions] High throughput no no
CSKI1_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
ARHG2_HUMAN [view entry] [view interactions] High throughput yes yes
AP2B1_HUMAN [view entry] [view interactions] High throughput yes yes
AP2A2_HUMAN [view entry] [view interactions] High throughput yes yes
AP2A1_HUMAN [view entry] [view interactions] High throughput yes yes
ANK2_HUMAN [view entry] [view interactions] High throughput yes yes
AGO3_HUMAN [view interactions] High throughput no yes
AGO1_HUMAN [view interactions] High throughput no no
ADDA_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
AKT3_HUMAN [view interactions] High throughput no yes
PEX13_HUMAN [view interactions] Computational no yes
PEX1_HUMAN [view interactions] Computational no no
GNPAT_HUMAN [view entry] [view interactions] Computational yes no
RAB8B_HUMAN [view entry] [view interactions] Computational yes no
PEX6_HUMAN [view interactions] Computational no yes
PEX10_HUMAN [view interactions] Computational no yes
PEX3_HUMAN [view interactions] Computational no yes
PEX16_HUMAN [view interactions] Computational no yes