PEX5R_HUMAN
Evidence for PS localization
Functions
Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PEX5R_HUMAN |
|---|---|---|---|---|
| GO:0045296 | cadherin binding | 25.6410 | 4 | no |
| GO:0003723 | RNA binding | 23.0769 | 4 | no |
| GO:0043169 | cation binding | 23.0769 | 4 | no |
| GO:0046872 | metal ion binding | 23.0769 | 5 | no |
| GO:0003779 | actin binding | 20.5128 | 4 | no |
| GO:0051020 | GTPase binding | 15.3846 | 4 | yes |
| GO:0031267 | small GTPase binding | 12.8205 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PEX5R_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 53.8462 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 48.7179 | 4 | no |
| GO:0010646 | regulation of cell communication | 41.0256 | 4 | yes |
| GO:0008104 | protein localization | 35.8974 | 4 | yes |
| GO:0022607 | cellular component assembly | 35.8974 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 35.8974 | 4 | no |
| GO:0009966 | regulation of signal transduction | 30.7692 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 30.7692 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 30.7692 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 28.2051 | 4 | no |
| GO:0033043 | regulation of organelle organization | 25.6410 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 25.6410 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 25.6410 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.6410 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.6410 | 5 | no |
| GO:0071702 | organic substance transport | 23.0769 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 23.0769 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 23.0769 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 23.0769 | 6 | no |
| GO:0006996 | organelle organization | 23.0769 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 23.0769 | 5 | no |
| GO:0030030 | cell projection organization | 23.0769 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 23.0769 | 5 | no |
| GO:0010468 | regulation of gene expression | 23.0769 | 6 | no |
| GO:0071310 | cellular response to organic substance | 23.0769 | 4 | no |
| GO:0015031 | protein transport | 20.5128 | 4 | no |
| GO:0071705 | nitrogen compound transport | 20.5128 | 4 | no |
| GO:0010975 | regulation of neuron projection development | 20.5128 | 7 | no |
| GO:0010243 | response to organonitrogen compound | 20.5128 | 4 | no |
| GO:0032970 | regulation of actin filament-based process | 20.5128 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 20.5128 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 20.5128 | 6 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 20.5128 | 5 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 20.5128 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 17.9487 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PEX14_HUMAN | [view interactions] | Low throughput | no | yes |
| HCN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HCN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| HCN3_HUMAN | [view interactions] | Low throughput | no | yes |
| PEX7_HUMAN | [view interactions] | Low throughput | no | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| K2C8_HUMAN | [view interactions] | High throughput | no | no |
| K1C18_HUMAN | [view interactions] | High throughput | no | no |
| RS25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADDA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGO1_HUMAN | [view interactions] | High throughput | no | no |
| AGO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGO3_HUMAN | [view interactions] | High throughput | no | yes |
| ANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARHG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSKI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAD11_HUMAN | [view interactions] | High throughput | no | no |
| CADH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTNA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTND2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GABR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GIT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCN4_HUMAN | [view interactions] | High throughput | no | yes |
| ICAM5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCD16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCAN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NCKP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARD3_HUMAN | [view interactions] | High throughput | no | yes |
| PEX5_HUMAN | [view interactions] | High throughput | no | yes |
| PPR3F_HUMAN | [view interactions] | High throughput | no | yes |
| SKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S12A5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S4A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TANC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TENR_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UN13A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WDR7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKT3_HUMAN | [view interactions] | High throughput | no | yes |
| ACVL1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |