ARHG2_HUMAN
Evidence for PS localization
Functions
Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability . Involved in neuronal progenitor cell division and differentiation (PubMed). Involved in the migration of precerebellar neurons . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI003167 | DOC_PP2A_B56_1 | DOC | 967 | 972 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ARHG2_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 31.1828 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 30.1075 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 30.1075 | 4 | no |
| GO:0019900 | kinase binding | 24.7312 | 4 | no |
| GO:0019901 | protein kinase binding | 23.6559 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 20.4301 | 5 | no |
| GO:0046872 | metal ion binding | 19.3548 | 4 | yes |
| GO:0015631 | tubulin binding | 11.8280 | 4 | yes |
| GO:0030695 | GTPase regulator activity | 10.7527 | 4 | yes |
| GO:0051020 | GTPase binding | 10.7527 | 4 | yes |
| GO:0031267 | small GTPase binding | 9.6774 | 5 | yes |
| GO:0008017 | microtubule binding | 8.6022 | 5 | yes |
| GO:0005085 | guanyl-nucleotide exchange factor activity | 5.3763 | 5 | yes |
| GO:0008270 | zinc ion binding | 5.3763 | 6 | yes |
| GO:0046914 | transition metal ion binding | 5.3763 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ARHG2_HUMAN |
|---|---|---|---|---|
| GO:0051128 | regulation of cellular component organization | 55.9140 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 54.8387 | 4 | yes |
| GO:0010646 | regulation of cell communication | 48.3871 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 47.3118 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 47.3118 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 47.3118 | 4 | yes |
| GO:0006996 | organelle organization | 46.2366 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 46.2366 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 46.2366 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 41.9355 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 36.5591 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 36.5591 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 35.4839 | 5 | yes |
| GO:0030030 | cell projection organization | 34.4086 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 34.4086 | 4 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 34.4086 | 6 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 34.4086 | 5 | yes |
| GO:0031399 | regulation of protein modification process | 34.4086 | 6 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 34.4086 | 5 | yes |
| GO:0007010 | cytoskeleton organization | 33.3333 | 5 | no |
| GO:0010468 | regulation of gene expression | 33.3333 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 32.2581 | 5 | yes |
| GO:0022607 | cellular component assembly | 31.1828 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 31.1828 | 5 | yes |
| GO:0051130 | positive regulation of cellular component organization | 30.1075 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.1075 | 5 | yes |
| GO:0033043 | regulation of organelle organization | 30.1075 | 5 | yes |
| GO:0042325 | regulation of phosphorylation | 30.1075 | 7 | yes |
| GO:0036211 | protein modification process | 29.0323 | 4 | no |
| GO:0043412 | macromolecule modification | 29.0323 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 29.0323 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 29.0323 | 6 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 29.0323 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 27.9570 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 27.9570 | 6 | yes |
| GO:0045937 | positive regulation of phosphate metabolic process | 27.9570 | 7 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 27.9570 | 6 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 27.9570 | 6 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 26.8817 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 26.8817 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 26.8817 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 26.8817 | 7 | yes |
| GO:0009892 | negative regulation of metabolic process | 25.8065 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 25.8065 | 7 | yes |
| GO:0042327 | positive regulation of phosphorylation | 25.8065 | 8 | yes |
| GO:0051252 | regulation of RNA metabolic process | 25.8065 | 5 | yes |
| GO:0008104 | protein localization | 24.7312 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 23.6559 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 23.6559 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 23.6559 | 4 | no |
| GO:0010941 | regulation of cell death | 23.6559 | 4 | yes |
| GO:0071310 | cellular response to organic substance | 23.6559 | 4 | yes |
| GO:0080134 | regulation of response to stress | 23.6559 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 22.5806 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 22.5806 | 5 | no |
| GO:0010975 | regulation of neuron projection development | 22.5806 | 7 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 22.5806 | 8 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 22.5806 | 6 | yes |
| GO:0045595 | regulation of cell differentiation | 22.5806 | 4 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 22.5806 | 5 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 22.5806 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 22.5806 | 6 | yes |
| GO:0010647 | positive regulation of cell communication | 21.5054 | 5 | no |
| GO:0023056 | positive regulation of signaling | 21.5054 | 4 | no |
| GO:0051338 | regulation of transferase activity | 20.4301 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 20.4301 | 5 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 20.4301 | 6 | yes |
| GO:0042981 | regulation of apoptotic process | 20.4301 | 6 | yes |
| GO:0043067 | regulation of programmed cell death | 20.4301 | 5 | yes |
| GO:0048585 | negative regulation of response to stimulus | 19.3548 | 4 | yes |
| GO:0097435 | supramolecular fiber organization | 19.3548 | 4 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 19.3548 | 4 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 18.2796 | 6 | yes |
| GO:0030334 | regulation of cell migration | 18.2796 | 5 | yes |
| GO:0051094 | positive regulation of developmental process | 18.2796 | 4 | yes |
| GO:0051129 | negative regulation of cellular component organization | 18.2796 | 5 | yes |
| GO:0071702 | organic substance transport | 18.2796 | 4 | yes |
| GO:0080135 | regulation of cellular response to stress | 18.2796 | 4 | yes |
| GO:2000145 | regulation of cell motility | 18.2796 | 4 | yes |
| GO:0010648 | negative regulation of cell communication | 17.2043 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 17.2043 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 17.2043 | 4 | yes |
| GO:0030335 | positive regulation of cell migration | 16.1290 | 6 | yes |
| GO:0040017 | positive regulation of locomotion | 16.1290 | 4 | yes |
| GO:0042127 | regulation of cell population proliferation | 16.1290 | 4 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 16.1290 | 6 | yes |
| GO:2000147 | positive regulation of cell motility | 16.1290 | 5 | yes |
| GO:0009968 | negative regulation of signal transduction | 15.0538 | 5 | yes |
| GO:0010243 | response to organonitrogen compound | 15.0538 | 4 | yes |
| GO:0015031 | protein transport | 15.0538 | 4 | yes |
| GO:0007015 | actin filament organization | 13.9785 | 5 | yes |
| GO:0032886 | regulation of microtubule-based process | 13.9785 | 4 | yes |
| GO:0006886 | intracellular protein transport | 12.9032 | 4 | yes |
| GO:0051254 | positive regulation of RNA metabolic process | 12.9032 | 6 | yes |
| GO:0070507 | regulation of microtubule cytoskeleton organization | 12.9032 | 5 | yes |
| GO:1901699 | cellular response to nitrogen compound | 12.9032 | 4 | yes |
| GO:0010628 | positive regulation of gene expression | 11.8280 | 6 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 11.8280 | 7 | yes |
| GO:0060548 | negative regulation of cell death | 11.8280 | 5 | yes |
| GO:1902532 | negative regulation of intracellular signal transduction | 11.8280 | 6 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 11.8280 | 7 | yes |
| GO:1903508 | positive regulation of nucleic acid-templated transcription | 11.8280 | 8 | yes |
| GO:0031110 | regulation of microtubule polymerization or depolymerization | 10.7527 | 6 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 10.7527 | 4 | yes |
| GO:0071417 | cellular response to organonitrogen compound | 10.7527 | 4 | yes |
| GO:0006357 | regulation of transcription by RNA polymerase II | 9.6774 | 7 | yes |
| GO:0010639 | negative regulation of organelle organization | 9.6774 | 6 | yes |
| GO:0034097 | response to cytokine | 9.6774 | 4 | yes |
| GO:0043066 | negative regulation of apoptotic process | 9.6774 | 7 | yes |
| GO:0043069 | negative regulation of programmed cell death | 9.6774 | 6 | yes |
| GO:0045597 | positive regulation of cell differentiation | 9.6774 | 5 | yes |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 9.6774 | 6 | yes |
| GO:1901652 | response to peptide | 9.6774 | 4 | yes |
| GO:1902904 | negative regulation of supramolecular fiber organization | 9.6774 | 6 | yes |
| GO:0051494 | negative regulation of cytoskeleton organization | 8.6022 | 7 | yes |
| GO:0071345 | cellular response to cytokine stimulus | 8.6022 | 5 | yes |
| GO:1901653 | cellular response to peptide | 8.6022 | 5 | yes |
| GO:0043244 | regulation of protein-containing complex disassembly | 7.5269 | 5 | yes |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | 7.5269 | 8 | yes |
| GO:0034612 | response to tumor necrosis factor | 6.4516 | 5 | yes |
| GO:0043242 | negative regulation of protein-containing complex disassembly | 6.4516 | 6 | yes |
| GO:0045664 | regulation of neuron differentiation | 6.4516 | 5 | yes |
| GO:0046578 | regulation of Ras protein signal transduction | 6.4516 | 7 | yes |
| GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 6.4516 | 8 | yes |
| GO:0051091 | positive regulation of DNA-binding transcription factor activity | 6.4516 | 4 | yes |
| GO:0062197 | cellular response to chemical stress | 6.4516 | 4 | yes |
| GO:1901879 | regulation of protein depolymerization | 6.4516 | 6 | yes |
| GO:1901880 | negative regulation of protein depolymerization | 6.4516 | 7 | yes |
| GO:2001233 | regulation of apoptotic signaling pathway | 5.3763 | 5 | yes |
| GO:0031111 | negative regulation of microtubule polymerization or depolymerization | 5.3763 | 7 | yes |
| GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 5.3763 | 5 | yes |
| GO:0071356 | cellular response to tumor necrosis factor | 5.3763 | 6 | yes |
| GO:0035023 | regulation of Rho protein signal transduction | 4.3011 | 8 | yes |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 4.3011 | 9 | yes |
| GO:2001222 | regulation of neuron migration | 4.3011 | 6 | yes |
| GO:2001234 | negative regulation of apoptotic signaling pathway | 3.2258 | 6 | yes |
| GO:2001236 | regulation of extrinsic apoptotic signaling pathway | 3.2258 | 6 | yes |
| GO:2001242 | regulation of intrinsic apoptotic signaling pathway | 3.2258 | 6 | yes |
| GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway | 3.2258 | 7 | yes |
| GO:0001817 | regulation of cytokine production | 3.2258 | 4 | yes |
| GO:0007026 | negative regulation of microtubule depolymerization | 3.2258 | 7 | yes |
| GO:0031114 | regulation of microtubule depolymerization | 3.2258 | 6 | yes |
| GO:0045666 | positive regulation of neuron differentiation | 3.2258 | 6 | yes |
| GO:2001224 | positive regulation of neuron migration | 3.2258 | 7 | yes |
| GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway | 2.1505 | 7 | yes |
| GO:0001819 | positive regulation of cytokine production | 2.1505 | 5 | yes |
| GO:0006972 | hyperosmotic response | 2.1505 | 4 | yes |
| GO:0010939 | regulation of necrotic cell death | 2.1505 | 5 | yes |
| GO:0032495 | response to muramyl dipeptide | 2.1505 | 5 | yes |
| GO:0032675 | regulation of interleukin-6 production | 2.1505 | 5 | yes |
| GO:0032680 | regulation of tumor necrosis factor production | 2.1505 | 6 | yes |
| GO:0032755 | positive regulation of interleukin-6 production | 2.1505 | 6 | yes |
| GO:0032760 | positive regulation of tumor necrosis factor production | 2.1505 | 7 | yes |
| GO:0047484 | regulation of response to osmotic stress | 2.1505 | 5 | yes |
| GO:0055059 | asymmetric neuroblast division | 2.1505 | 4 | yes |
| GO:0060544 | regulation of necroptotic process | 2.1505 | 7 | yes |
| GO:0060546 | negative regulation of necroptotic process | 2.1505 | 8 | yes |
| GO:0060547 | negative regulation of necrotic cell death | 2.1505 | 6 | yes |
| GO:0062098 | regulation of programmed necrotic cell death | 2.1505 | 6 | yes |
| GO:0062099 | negative regulation of programmed necrotic cell death | 2.1505 | 7 | yes |
| GO:0071225 | cellular response to muramyl dipeptide | 2.1505 | 6 | yes |
| GO:0071470 | cellular response to osmotic stress | 2.1505 | 4 | yes |
| GO:0071474 | cellular hyperosmotic response | 2.1505 | 5 | yes |
| GO:0106049 | regulation of cellular response to osmotic stress | 2.1505 | 5 | yes |
| GO:1902041 | regulation of extrinsic apoptotic signaling pathway via death domain receptors | 2.1505 | 7 | yes |
| GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | 2.1505 | 8 | yes |
| GO:1902218 | regulation of intrinsic apoptotic signaling pathway in response to osmotic stress | 2.1505 | 6 | yes |
| GO:1902219 | negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress | 2.1505 | 7 | yes |
| GO:1903555 | regulation of tumor necrosis factor superfamily cytokine production | 2.1505 | 5 | yes |
| GO:1903557 | positive regulation of tumor necrosis factor superfamily cytokine production | 2.1505 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NEB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DYLT1_HUMAN | [view interactions] | Low throughput | no | no |
| OGG1_HUMAN | [view interactions] | Low throughput | no | yes |
| PAXI_HUMAN | [view interactions] | Low throughput | no | yes |
| RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NEB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MARK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PAK4_HUMAN | [view interactions] | Low throughput | no | yes |
| KSR1_HUMAN | [view interactions] | Low throughput | no | yes |
| 1433T_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MARK3_HUMAN | [view interactions] | Low throughput | no | yes |
| RHOB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FYB1_HUMAN | [view interactions] | Low throughput | no | no |
| ASAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTPRF_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK01_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBP21_HUMAN | [view interactions] | Low throughput | no | no |
| MMS19_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| CP250_HUMAN | [view interactions] | High throughput | no | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| WDR83_HUMAN | [view interactions] | High throughput | no | yes |
| FGL1_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KIFC1_HUMAN | [view interactions] | High throughput | no | yes |
| RAD18_HUMAN | [view interactions] | High throughput | no | yes |
| PAK5_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| UBE2A_HUMAN | [view interactions] | High throughput | no | no |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| RNF31_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| PP6R2_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BACH1_HUMAN | [view interactions] | High throughput | no | no |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
| RU17_HUMAN | [view interactions] | High throughput | no | yes |
| PLK1_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| MRCKA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FUBP1_HUMAN | [view interactions] | High throughput | no | yes |
| LRC31_HUMAN | [view interactions] | High throughput | no | no |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| BAG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TULP3_HUMAN | [view interactions] | High throughput | no | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| ZNRF2_HUMAN | [view interactions] | High throughput | no | yes |
| FBSP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPB1_HUMAN | [view interactions] | High throughput | no | yes |
| SPSB4_HUMAN | [view interactions] | High throughput | no | no |
| PNMA2_HUMAN | [view interactions] | High throughput | no | yes |
| KCNE3_HUMAN | [view interactions] | High throughput | no | yes |
| RL26L_HUMAN | [view interactions] | High throughput | no | yes |
| HNRC2_HUMAN | [view interactions] | High throughput | no | no |
| HECD1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI52_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT44_HUMAN | [view interactions] | High throughput | no | yes |
| CIA2A_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| LUR1L_HUMAN | [view interactions] | High throughput | no | no |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| SIR6_HUMAN | [view interactions] | High throughput | no | yes |
| RL35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSN7A_HUMAN | [view interactions] | High throughput | no | yes |
| KLC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSME3_HUMAN | [view interactions] | High throughput | no | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SELH_HUMAN | [view interactions] | High throughput | no | yes |
| WASF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAZA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DBNL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPM4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG40_HUMAN | [view interactions] | High throughput | no | no |
| RHG42_HUMAN | [view interactions] | High throughput | no | yes |
| BBLN_HUMAN | [view interactions] | High throughput | no | yes |
| DAB2P_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EPS8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FCHO2_HUMAN | [view interactions] | High throughput | no | yes |
| PRIC1_HUMAN | [view interactions] | High throughput | no | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEGT_HUMAN | [view interactions] | High throughput | no | yes |
| ARHG7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHIO_HUMAN | [view interactions] | High throughput | no | yes |
| URP2_HUMAN | [view interactions] | High throughput | no | no |
| FGD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDLI5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRIC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRBS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VINEX_HUMAN | [view interactions] | High throughput | no | no |
| SRGP1_HUMAN | [view interactions] | High throughput | no | no |
| STRP2_HUMAN | [view interactions] | High throughput | no | yes |
| VINC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CKAP2_HUMAN | [view interactions] | High throughput | no | yes |
| MA7D3_HUMAN | [view interactions] | High throughput | no | no |
| PKHA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANR52_HUMAN | [view interactions] | High throughput | no | yes |
| PLST_HUMAN | [view interactions] | High throughput | no | yes |
| CAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SKA1_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAP1S_HUMAN | [view interactions] | High throughput | no | no |
| MAP7_HUMAN | [view interactions] | High throughput | no | yes |
| MTUS1_HUMAN | [view interactions] | High throughput | no | no |
| NCK1_HUMAN | [view interactions] | High throughput | no | yes |
| GTSE1_HUMAN | [view interactions] | High throughput | no | no |
| 2A5D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| MA7D2_HUMAN | [view interactions] | High throughput | no | yes |
| DCLK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDZ11_HUMAN | [view interactions] | High throughput | no | yes |
| C170B_HUMAN | [view interactions] | High throughput | no | yes |
| MAP9_HUMAN | [view interactions] | High throughput | no | no |
| DVL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEDD1_HUMAN | [view interactions] | High throughput | no | yes |
| SRP54_HUMAN | [view interactions] | High throughput | no | yes |
| ARHG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| MIC26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI36_HUMAN | [view interactions] | High throughput | no | no |
| VP33B_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARK4_HUMAN | [view interactions] | High throughput | no | yes |
| PPP6_HUMAN | [view interactions] | High throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANR28_HUMAN | [view interactions] | High throughput | no | no |
| PP6R1_HUMAN | [view interactions] | High throughput | no | no |
| 2A5B_HUMAN | [view interactions] | High throughput | no | yes |
| 2A5A_HUMAN | [view interactions] | High throughput | no | yes |
| 2A5E_HUMAN | [view interactions] | High throughput | no | yes |
| PP2AB_HUMAN | [view interactions] | High throughput | no | yes |
| 2ABA_HUMAN | [view interactions] | High throughput | no | yes |
| TRPM7_HUMAN | [view interactions] | High throughput | no | no |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUDC1_HUMAN | [view interactions] | High throughput | no | no |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| SORL_HUMAN | [view interactions] | High throughput | no | yes |
| PP6R3_HUMAN | [view interactions] | High throughput | no | yes |
| KCRU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP2AA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| PEX14_HUMAN | [view interactions] | High throughput | no | yes |
| FOXO3_HUMAN | [view interactions] | High throughput | no | yes |
| M3K14_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| PTBP3_HUMAN | [view interactions] | High throughput | no | no |
| USE1_HUMAN | [view interactions] | High throughput | no | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PEX5R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| RP25L_HUMAN | [view interactions] | High throughput | no | yes |
| IKBD_HUMAN | [view interactions] | High throughput | no | no |
| IKBE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| RAB38_HUMAN | [view interactions] | High throughput | no | no |
| NOTC1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| AKA10_HUMAN | [view interactions] | High throughput | no | no |
| CE170_HUMAN | [view interactions] | High throughput | no | yes |
| SCLT1_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNTRL_HUMAN | [view interactions] | High throughput | no | yes |
| AKIP_HUMAN | [view interactions] | High throughput | no | yes |
| BET1_HUMAN | [view interactions] | High throughput | no | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYRK2_HUMAN | [view interactions] | High throughput | no | yes |
| ALK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| VGFR1_HUMAN | [view interactions] | High throughput | no | no |
| FLT3_HUMAN | [view interactions] | High throughput | no | no |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MERTK_HUMAN | [view interactions] | High throughput | no | yes |
| PGFRB_HUMAN | [view interactions] | High throughput | no | yes |
| ROS1_HUMAN | [view interactions] | High throughput | no | no |
| PLCG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAF10_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TBA1B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RIPK2_HUMAN | [view interactions] | Computational | no | yes |
| TBB4A_HUMAN | [view interactions] | Computational | no | yes |
| TBB1_HUMAN | [view interactions] | Computational | no | yes |
| RELN_HUMAN | [view interactions] | Computational | no | no |
| CGNL1_HUMAN | [view interactions] | Computational | no | no |
| TBA4A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TBA3E_HUMAN | [view interactions] | Computational | no | no |
| CING_HUMAN | [view interactions] | Computational | no | no |
| TBB2B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TBB6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TBA8_HUMAN | [view interactions] | Computational | no | yes |
| TBA1C_HUMAN | [view interactions] | Computational | no | yes |
| TBB8_HUMAN | [view interactions] | Computational | no | no |
| MK08_HUMAN | [view interactions] | Computational | no | yes |
| FAK1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| M3K11_HUMAN | [view interactions] | Computational | no | yes |
| FYN_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| MP2K7_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| EXOC2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| TBA3D_HUMAN | [view interactions] | Computational | no | no |
| TBA3C_HUMAN | [view interactions] | Computational | no | no |
| TBB5_HUMAN | [view interactions] | Computational | no | yes |
| DAB1_HUMAN | [view interactions] | Computational | no | yes |
| NOD1_HUMAN | [view interactions] | Computational | no | no |
| TBAL3_HUMAN | [view interactions] | Computational | no | no |
| LRP8_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| TBB2A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TBB4B_HUMAN | [view interactions] | Computational | no | yes |