ARHG2_HUMAN
Evidence for PS localization
Functions
Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability . Involved in neuronal progenitor cell division and differentiation (PubMed). Involved in the migration of precerebellar neurons . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI003167 | DOC_PP2A_B56_1 | DOC | 967 | 972 | - |
| ELMI003167 | DOC_PP2A_B56_1 | DOC | 967 | 972 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ARHG2_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 23.9583 | 4 | no |
| GO:0019900 | kinase binding | 23.9583 | 4 | no |
| GO:0019901 | protein kinase binding | 22.9167 | 5 | no |
| GO:0000166 | nucleotide binding | 21.8750 | 4 | no |
| GO:0017076 | purine nucleotide binding | 21.8750 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 21.8750 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.8750 | 4 | no |
| GO:0043169 | cation binding | 19.7917 | 4 | yes |
| GO:0046872 | metal ion binding | 19.7917 | 5 | yes |
| GO:0015631 | tubulin binding | 12.5000 | 4 | yes |
| GO:0030695 | GTPase regulator activity | 12.5000 | 4 | yes |
| GO:0051020 | GTPase binding | 12.5000 | 4 | yes |
| GO:0031267 | small GTPase binding | 10.4167 | 5 | yes |
| GO:0008017 | microtubule binding | 9.3750 | 5 | yes |
| GO:0005085 | guanyl-nucleotide exchange factor activity | 7.2917 | 5 | yes |
| GO:0008270 | zinc ion binding | 7.2917 | 7 | yes |
| GO:0046914 | transition metal ion binding | 7.2917 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ARHG2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 57.2917 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 56.2500 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 55.2083 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 55.2083 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 55.2083 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 54.1667 | 4 | yes |
| GO:0010646 | regulation of cell communication | 53.1250 | 4 | yes |
| GO:0006996 | organelle organization | 44.7917 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 44.7917 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 44.7917 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 43.7500 | 5 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 42.7083 | 5 | yes |
| GO:0022607 | cellular component assembly | 40.6250 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 39.5833 | 4 | yes |
| GO:0010468 | regulation of gene expression | 39.5833 | 6 | yes |
| GO:0051246 | regulation of protein metabolic process | 38.5417 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 38.5417 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 36.4583 | 5 | yes |
| GO:0030030 | cell projection organization | 35.4167 | 4 | no |
| GO:0008104 | protein localization | 35.4167 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 35.4167 | 5 | yes |
| GO:0031399 | regulation of protein modification process | 35.4167 | 6 | yes |
| GO:0009892 | negative regulation of metabolic process | 34.3750 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 33.3333 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 33.3333 | 5 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 31.2500 | 5 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 31.2500 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 31.2500 | 6 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 30.2083 | 6 | yes |
| GO:0036211 | protein modification process | 30.2083 | 4 | no |
| GO:0043412 | macromolecule modification | 30.2083 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 30.2083 | 7 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 29.1667 | 6 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 29.1667 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 29.1667 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 28.1250 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 28.1250 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 27.0833 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 27.0833 | 7 | yes |
| GO:0048584 | positive regulation of response to stimulus | 26.0417 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 26.0417 | 7 | yes |
| GO:0031401 | positive regulation of protein modification process | 26.0417 | 7 | yes |
| GO:0033043 | regulation of organelle organization | 26.0417 | 5 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 25.0000 | 6 | yes |
| GO:0031344 | regulation of cell projection organization | 25.0000 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 25.0000 | 6 | no |
| GO:0007010 | cytoskeleton organization | 25.0000 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 25.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 25.0000 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 25.0000 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 25.0000 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 25.0000 | 5 | yes |
| GO:0043067 | regulation of programmed cell death | 25.0000 | 4 | yes |
| GO:0045595 | regulation of cell differentiation | 25.0000 | 4 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 23.9583 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 23.9583 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 23.9583 | 5 | yes |
| GO:0009968 | negative regulation of signal transduction | 23.9583 | 5 | yes |
| GO:0141124 | intracellular signaling cassette | 22.9167 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 22.9167 | 6 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 22.9167 | 6 | yes |
| GO:0045937 | positive regulation of phosphate metabolic process | 22.9167 | 7 | yes |
| GO:0071702 | organic substance transport | 21.8750 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 21.8750 | 5 | no |
| GO:0009890 | negative regulation of biosynthetic process | 21.8750 | 5 | no |
| GO:0051049 | regulation of transport | 21.8750 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 21.8750 | 6 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 20.8333 | 5 | yes |
| GO:2000145 | regulation of cell motility | 20.8333 | 4 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 20.8333 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 20.8333 | 6 | no |
| GO:0042327 | positive regulation of phosphorylation | 20.8333 | 8 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 20.8333 | 5 | yes |
| GO:0097435 | supramolecular fiber organization | 19.7917 | 4 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 19.7917 | 8 | yes |
| GO:0030334 | regulation of cell migration | 19.7917 | 5 | yes |
| GO:0042127 | regulation of cell population proliferation | 19.7917 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 19.7917 | 4 | yes |
| GO:0051129 | negative regulation of cellular component organization | 18.7500 | 5 | yes |
| GO:0071310 | cellular response to organic substance | 18.7500 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 18.7500 | 4 | yes |
| GO:0080134 | regulation of response to stress | 18.7500 | 4 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 17.7083 | 4 | yes |
| GO:2000147 | positive regulation of cell motility | 17.7083 | 5 | yes |
| GO:0006357 | regulation of transcription by RNA polymerase II | 17.7083 | 8 | yes |
| GO:0030335 | positive regulation of cell migration | 17.7083 | 6 | yes |
| GO:0040017 | positive regulation of locomotion | 17.7083 | 4 | yes |
| GO:0051254 | positive regulation of RNA metabolic process | 16.6667 | 6 | yes |
| GO:0015031 | protein transport | 16.6667 | 4 | yes |
| GO:1902532 | negative regulation of intracellular signal transduction | 15.6250 | 6 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 15.6250 | 7 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 15.6250 | 8 | yes |
| GO:0007015 | actin filament organization | 14.5833 | 5 | yes |
| GO:0010243 | response to organonitrogen compound | 14.5833 | 4 | yes |
| GO:0032886 | regulation of microtubule-based process | 14.5833 | 4 | yes |
| GO:0070507 | regulation of microtubule cytoskeleton organization | 13.5417 | 5 | yes |
| GO:0006886 | intracellular protein transport | 13.5417 | 4 | yes |
| GO:0043066 | negative regulation of apoptotic process | 13.5417 | 6 | yes |
| GO:0043069 | negative regulation of programmed cell death | 13.5417 | 5 | yes |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 13.5417 | 6 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 11.4583 | 4 | yes |
| GO:0080135 | regulation of cellular response to stress | 11.4583 | 4 | yes |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | 11.4583 | 9 | yes |
| GO:1902904 | negative regulation of supramolecular fiber organization | 10.4167 | 6 | yes |
| GO:0010628 | positive regulation of gene expression | 10.4167 | 7 | yes |
| GO:0010639 | negative regulation of organelle organization | 10.4167 | 6 | yes |
| GO:0031110 | regulation of microtubule polymerization or depolymerization | 10.4167 | 6 | yes |
| GO:0051494 | negative regulation of cytoskeleton organization | 9.3750 | 7 | yes |
| GO:0071417 | cellular response to organonitrogen compound | 9.3750 | 4 | yes |
| GO:1901699 | cellular response to nitrogen compound | 9.3750 | 4 | yes |
| GO:0045597 | positive regulation of cell differentiation | 9.3750 | 5 | yes |
| GO:0071345 | cellular response to cytokine stimulus | 8.3333 | 5 | yes |
| GO:2001233 | regulation of apoptotic signaling pathway | 8.3333 | 5 | yes |
| GO:0034097 | response to cytokine | 8.3333 | 4 | yes |
| GO:0045664 | regulation of neuron differentiation | 8.3333 | 5 | yes |
| GO:0062197 | cellular response to chemical stress | 7.2917 | 4 | yes |
| GO:0140546 | defense response to symbiont | 7.2917 | 4 | yes |
| GO:0035023 | regulation of Rho protein signal transduction | 7.2917 | 7 | yes |
| GO:0043244 | regulation of protein-containing complex disassembly | 7.2917 | 5 | yes |
| GO:1901879 | regulation of protein depolymerization | 6.2500 | 6 | yes |
| GO:1901880 | negative regulation of protein depolymerization | 6.2500 | 7 | yes |
| GO:0001817 | regulation of cytokine production | 6.2500 | 4 | yes |
| GO:0043242 | negative regulation of protein-containing complex disassembly | 6.2500 | 6 | yes |
| GO:0071356 | cellular response to tumor necrosis factor | 5.2083 | 6 | yes |
| GO:2001234 | negative regulation of apoptotic signaling pathway | 5.2083 | 6 | yes |
| GO:2001236 | regulation of extrinsic apoptotic signaling pathway | 5.2083 | 6 | yes |
| GO:0031111 | negative regulation of microtubule polymerization or depolymerization | 5.2083 | 7 | yes |
| GO:0034612 | response to tumor necrosis factor | 5.2083 | 5 | yes |
| GO:0051091 | positive regulation of DNA-binding transcription factor activity | 5.2083 | 4 | yes |
| GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 5.2083 | 5 | yes |
| GO:2001222 | regulation of neuron migration | 4.1667 | 6 | yes |
| GO:2001242 | regulation of intrinsic apoptotic signaling pathway | 4.1667 | 6 | yes |
| GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway | 4.1667 | 7 | yes |
| GO:0045666 | positive regulation of neuron differentiation | 4.1667 | 6 | yes |
| GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 4.1667 | 8 | yes |
| GO:0060544 | regulation of necroptotic process | 3.1250 | 6 | yes |
| GO:0062098 | regulation of programmed necrotic cell death | 3.1250 | 5 | yes |
| GO:1902041 | regulation of extrinsic apoptotic signaling pathway via death domain receptors | 3.1250 | 7 | yes |
| GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | 3.1250 | 8 | yes |
| GO:1903555 | regulation of tumor necrosis factor superfamily cytokine production | 3.1250 | 5 | yes |
| GO:2001224 | positive regulation of neuron migration | 3.1250 | 7 | yes |
| GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway | 3.1250 | 7 | yes |
| GO:0007026 | negative regulation of microtubule depolymerization | 3.1250 | 7 | yes |
| GO:0031114 | regulation of microtubule depolymerization | 3.1250 | 6 | yes |
| GO:0032495 | response to muramyl dipeptide | 3.1250 | 4 | yes |
| GO:0032680 | regulation of tumor necrosis factor production | 3.1250 | 6 | yes |
| GO:0055059 | asymmetric neuroblast division | 2.0833 | 4 | yes |
| GO:0060546 | negative regulation of necroptotic process | 2.0833 | 7 | yes |
| GO:0062099 | negative regulation of programmed necrotic cell death | 2.0833 | 6 | yes |
| GO:0071225 | cellular response to muramyl dipeptide | 2.0833 | 5 | yes |
| GO:0071470 | cellular response to osmotic stress | 2.0833 | 4 | yes |
| GO:0071474 | cellular hyperosmotic response | 2.0833 | 5 | yes |
| GO:0106049 | regulation of cellular response to osmotic stress | 2.0833 | 5 | yes |
| GO:1902218 | regulation of intrinsic apoptotic signaling pathway in response to osmotic stress | 2.0833 | 6 | yes |
| GO:1902219 | negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress | 2.0833 | 7 | yes |
| GO:1903557 | positive regulation of tumor necrosis factor superfamily cytokine production | 2.0833 | 6 | yes |
| GO:0001819 | positive regulation of cytokine production | 2.0833 | 5 | yes |
| GO:0006972 | hyperosmotic response | 2.0833 | 4 | yes |
| GO:0032675 | regulation of interleukin-6 production | 2.0833 | 5 | yes |
| GO:0032755 | positive regulation of interleukin-6 production | 2.0833 | 6 | yes |
| GO:0032760 | positive regulation of tumor necrosis factor production | 2.0833 | 7 | yes |
| GO:0047484 | regulation of response to osmotic stress | 2.0833 | 5 | yes |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 2.0833 | 9 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MARK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PAK4_HUMAN | [view interactions] | Low throughput | no | yes |
| NEB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KSR1_HUMAN | [view interactions] | Low throughput | no | yes |
| 1433T_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RHOA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MARK3_HUMAN | [view interactions] | Low throughput | no | yes |
| RHOB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FYB1_HUMAN | [view interactions] | Low throughput | no | no |
| ASAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTPRF_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK01_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBP21_HUMAN | [view interactions] | Low throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DYLT1_HUMAN | [view interactions] | Low throughput | no | no |
| OGG1_HUMAN | [view interactions] | Low throughput | no | yes |
| PAXI_HUMAN | [view interactions] | Low throughput | no | yes |
| HECD1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI52_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT44_HUMAN | [view interactions] | High throughput | no | yes |
| CIA2A_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| LUR1L_HUMAN | [view interactions] | High throughput | no | no |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| SIR6_HUMAN | [view interactions] | High throughput | no | yes |
| RL35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANM1_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| CAVN3_HUMAN | [view interactions] | High throughput | no | no |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| VIGLN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SLX4_HUMAN | [view interactions] | High throughput | no | yes |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| B3GN2_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSN7A_HUMAN | [view interactions] | High throughput | no | yes |
| KLC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSME3_HUMAN | [view interactions] | High throughput | no | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SELH_HUMAN | [view interactions] | High throughput | no | yes |
| WASF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAZA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DBNL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPM4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG40_HUMAN | [view interactions] | High throughput | no | no |
| RHG42_HUMAN | [view interactions] | High throughput | no | yes |
| BBLN_HUMAN | [view interactions] | High throughput | no | yes |
| DAB2P_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EPS8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FCHO2_HUMAN | [view interactions] | High throughput | no | yes |
| PRIC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEGT_HUMAN | [view interactions] | High throughput | no | yes |
| ARHG7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHIO_HUMAN | [view interactions] | High throughput | no | yes |
| URP2_HUMAN | [view interactions] | High throughput | no | no |
| FGD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDLI5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRIC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRBS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VINEX_HUMAN | [view interactions] | High throughput | no | no |
| SRGP1_HUMAN | [view interactions] | High throughput | no | no |
| STRP2_HUMAN | [view interactions] | High throughput | no | yes |
| VINC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP3B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGN2_HUMAN | [view interactions] | High throughput | no | no |
| NEDD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WASC5_HUMAN | [view interactions] | High throughput | no | yes |
| WASC4_HUMAN | [view interactions] | High throughput | no | yes |
| FKB15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WAC2A_HUMAN | [view interactions] | High throughput | no | yes |
| ARHG1_HUMAN | [view interactions] | High throughput | no | no |
| DOCK7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CKAP2_HUMAN | [view interactions] | High throughput | no | yes |
| MA7D3_HUMAN | [view interactions] | High throughput | no | no |
| PKHA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANR52_HUMAN | [view interactions] | High throughput | no | yes |
| PLST_HUMAN | [view interactions] | High throughput | no | yes |
| CAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SKA1_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAP1S_HUMAN | [view interactions] | High throughput | no | no |
| MAP7_HUMAN | [view interactions] | High throughput | no | yes |
| MTUS1_HUMAN | [view interactions] | High throughput | no | no |
| NCK1_HUMAN | [view interactions] | High throughput | no | yes |
| GTSE1_HUMAN | [view interactions] | High throughput | no | no |
| 2A5D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| MA7D2_HUMAN | [view interactions] | High throughput | no | yes |
| DCLK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDZ11_HUMAN | [view interactions] | High throughput | no | yes |
| C170B_HUMAN | [view interactions] | High throughput | no | yes |
| MAP9_HUMAN | [view interactions] | High throughput | no | no |
| DVL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEDD1_HUMAN | [view interactions] | High throughput | no | yes |
| SRP54_HUMAN | [view interactions] | High throughput | no | yes |
| ARHG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| MIC26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI36_HUMAN | [view interactions] | High throughput | no | no |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VP33B_HUMAN | [view interactions] | High throughput | no | yes |
| MARK4_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| GBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPP6_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANR28_HUMAN | [view interactions] | High throughput | no | no |
| PP6R1_HUMAN | [view interactions] | High throughput | no | no |
| 2A5B_HUMAN | [view interactions] | High throughput | no | yes |
| 2A5E_HUMAN | [view interactions] | High throughput | no | yes |
| PP2AB_HUMAN | [view interactions] | High throughput | no | yes |
| 2A5A_HUMAN | [view interactions] | High throughput | no | yes |
| 2ABA_HUMAN | [view interactions] | High throughput | no | yes |
| TRPM7_HUMAN | [view interactions] | High throughput | no | no |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUDC1_HUMAN | [view interactions] | High throughput | no | no |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| KCRU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP6R3_HUMAN | [view interactions] | High throughput | no | yes |
| SORL_HUMAN | [view interactions] | High throughput | no | yes |
| PP2AA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEX14_HUMAN | [view interactions] | High throughput | no | yes |
| FOXO3_HUMAN | [view interactions] | High throughput | no | yes |
| M3K14_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| PTBP3_HUMAN | [view interactions] | High throughput | no | no |
| USE1_HUMAN | [view interactions] | High throughput | no | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PEX5R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| LN28A_HUMAN | [view interactions] | High throughput | no | no |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| MD13L_HUMAN | [view interactions] | High throughput | no | no |
| RP25L_HUMAN | [view interactions] | High throughput | no | yes |
| IKBD_HUMAN | [view interactions] | High throughput | no | no |
| IKBE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| RAB38_HUMAN | [view interactions] | High throughput | no | no |
| NOTC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| AKA10_HUMAN | [view interactions] | High throughput | no | no |
| CE170_HUMAN | [view interactions] | High throughput | no | yes |
| SCLT1_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNTRL_HUMAN | [view interactions] | High throughput | no | yes |
| AKIP_HUMAN | [view interactions] | High throughput | no | yes |
| BET1_HUMAN | [view interactions] | High throughput | no | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYRK2_HUMAN | [view interactions] | High throughput | no | yes |
| ALK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VGFR1_HUMAN | [view interactions] | High throughput | no | no |
| FLT3_HUMAN | [view interactions] | High throughput | no | no |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MERTK_HUMAN | [view interactions] | High throughput | no | yes |
| PGFRB_HUMAN | [view interactions] | High throughput | no | yes |
| ROS1_HUMAN | [view interactions] | High throughput | no | no |
| PLCG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAF10_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MMS19_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| CP250_HUMAN | [view interactions] | High throughput | no | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| WDR83_HUMAN | [view interactions] | High throughput | no | yes |
| FGL1_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KIFC1_HUMAN | [view interactions] | High throughput | no | yes |
| RAD18_HUMAN | [view interactions] | High throughput | no | yes |
| PAK5_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| UBE2A_HUMAN | [view interactions] | High throughput | no | no |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| RNF31_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| PP6R2_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BACH1_HUMAN | [view interactions] | High throughput | no | no |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
| RU17_HUMAN | [view interactions] | High throughput | no | yes |
| PLK1_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| MRCKA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FUBP1_HUMAN | [view interactions] | High throughput | no | yes |
| LRC31_HUMAN | [view interactions] | High throughput | no | no |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| BAG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TULP3_HUMAN | [view interactions] | High throughput | no | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| ZNRF2_HUMAN | [view interactions] | High throughput | no | yes |
| FBSP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPB1_HUMAN | [view interactions] | High throughput | no | yes |
| SPSB4_HUMAN | [view interactions] | High throughput | no | no |
| PNMA2_HUMAN | [view interactions] | High throughput | no | yes |
| KCNE3_HUMAN | [view interactions] | High throughput | no | yes |
| RL26L_HUMAN | [view interactions] | High throughput | no | yes |
| HNRC2_HUMAN | [view interactions] | High throughput | no | no |