WASF1_HUMAN
Evidence for PS localization
Functions
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation (PubMed). The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex . As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes . Also involved in the regulation of mitochondrial dynamics (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI001663 | LIG_Actin_WH2_1 | LIG | 498 | 514 | - |
| ELMI003408 | LIG_PROFILIN_1 | LIG | 326 | 332 | - |
| ELMI001663 | LIG_Actin_WH2_1 | LIG | 498 | 514 | - |
| ELMI003408 | LIG_PROFILIN_1 | LIG | 326 | 332 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in WASF1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 33.8462 | 4 | no |
| GO:0000166 | nucleotide binding | 29.2308 | 4 | no |
| GO:0017076 | purine nucleotide binding | 29.2308 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 29.2308 | 4 | no |
| GO:0019900 | kinase binding | 27.6923 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.6923 | 4 | no |
| GO:0019901 | protein kinase binding | 24.6154 | 5 | no |
| GO:0003779 | actin binding | 21.5385 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 21.5385 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 21.5385 | 5 | no |
| GO:0034237 | protein kinase A regulatory subunit binding | 6.1538 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in WASF1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 72.3077 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 69.2308 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 56.9231 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 55.3846 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 52.3077 | 4 | no |
| GO:0010646 | regulation of cell communication | 52.3077 | 4 | yes |
| GO:0022607 | cellular component assembly | 52.3077 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 50.7692 | 4 | no |
| GO:0009966 | regulation of signal transduction | 44.6154 | 4 | yes |
| GO:0031344 | regulation of cell projection organization | 43.0769 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 43.0769 | 6 | no |
| GO:0030030 | cell projection organization | 43.0769 | 4 | yes |
| GO:0006996 | organelle organization | 41.5385 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 41.5385 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 40.0000 | 5 | no |
| GO:0033043 | regulation of organelle organization | 40.0000 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 38.4615 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 36.9231 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 36.9231 | 5 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 35.3846 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 35.3846 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 33.8462 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 33.8462 | 4 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 33.8462 | 6 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 32.3077 | 5 | no |
| GO:0031399 | regulation of protein modification process | 32.3077 | 6 | no |
| GO:0008104 | protein localization | 32.3077 | 4 | no |
| GO:0051049 | regulation of transport | 32.3077 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 32.3077 | 6 | yes |
| GO:0141124 | intracellular signaling cassette | 32.3077 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 32.3077 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.7692 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 30.7692 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 30.7692 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 30.7692 | 4 | yes |
| GO:0010468 | regulation of gene expression | 30.7692 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.7692 | 5 | no |
| GO:0007010 | cytoskeleton organization | 29.2308 | 5 | yes |
| GO:0032956 | regulation of actin cytoskeleton organization | 29.2308 | 5 | yes |
| GO:0032970 | regulation of actin filament-based process | 29.2308 | 4 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 29.2308 | 5 | yes |
| GO:0042325 | regulation of phosphorylation | 27.6923 | 7 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 27.6923 | 5 | no |
| GO:0030334 | regulation of cell migration | 27.6923 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 27.6923 | 4 | no |
| GO:2000145 | regulation of cell motility | 27.6923 | 4 | no |
| GO:0110053 | regulation of actin filament organization | 27.6923 | 6 | yes |
| GO:0009892 | negative regulation of metabolic process | 27.6923 | 4 | no |
| GO:0010975 | regulation of neuron projection development | 26.1538 | 7 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 26.1538 | 5 | no |
| GO:0071310 | cellular response to organic substance | 26.1538 | 4 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 26.1538 | 4 | no |
| GO:0007015 | actin filament organization | 26.1538 | 5 | yes |
| GO:0009967 | positive regulation of signal transduction | 26.1538 | 5 | yes |
| GO:0097435 | supramolecular fiber organization | 26.1538 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 26.1538 | 7 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.1538 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 24.6154 | 5 | no |
| GO:0031346 | positive regulation of cell projection organization | 24.6154 | 6 | no |
| GO:0050807 | regulation of synapse organization | 24.6154 | 5 | no |
| GO:2000026 | regulation of multicellular organismal development | 24.6154 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 24.6154 | 5 | no |
| GO:0034330 | cell junction organization | 24.6154 | 4 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 24.6154 | 4 | yes |
| GO:0042127 | regulation of cell population proliferation | 23.0769 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 23.0769 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 23.0769 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 23.0769 | 6 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 23.0769 | 4 | no |
| GO:0036211 | protein modification process | 23.0769 | 4 | no |
| GO:0043412 | macromolecule modification | 23.0769 | 4 | no |
| GO:0010638 | positive regulation of organelle organization | 23.0769 | 6 | yes |
| GO:0043933 | protein-containing complex organization | 23.0769 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 23.0769 | 5 | no |
| GO:0030031 | cell projection assembly | 21.5385 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 21.5385 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 21.5385 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 21.5385 | 4 | no |
| GO:0048812 | neuron projection morphogenesis | 21.5385 | 5 | no |
| GO:0060284 | regulation of cell development | 21.5385 | 5 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 21.5385 | 4 | no |
| GO:0031175 | neuron projection development | 21.5385 | 6 | no |
| GO:0051495 | positive regulation of cytoskeleton organization | 21.5385 | 7 | yes |
| GO:1902905 | positive regulation of supramolecular fiber organization | 21.5385 | 6 | yes |
| GO:0010648 | negative regulation of cell communication | 21.5385 | 5 | no |
| GO:0023057 | negative regulation of signaling | 21.5385 | 4 | no |
| GO:0007264 | small GTPase-mediated signal transduction | 18.4615 | 5 | yes |
| GO:0065003 | protein-containing complex assembly | 18.4615 | 5 | yes |
| GO:0050808 | synapse organization | 16.9231 | 5 | yes |
| GO:0008154 | actin polymerization or depolymerization | 13.8462 | 6 | yes |
| GO:0016601 | Rac protein signal transduction | 10.7692 | 6 | yes |
| GO:0071363 | cellular response to growth factor stimulus | 10.7692 | 4 | yes |
| GO:0097581 | lamellipodium organization | 10.7692 | 6 | yes |
| GO:0030041 | actin filament polymerization | 9.2308 | 7 | yes |
| GO:0034315 | regulation of Arp2/3 complex-mediated actin nucleation | 9.2308 | 8 | yes |
| GO:0051125 | regulation of actin nucleation | 9.2308 | 7 | yes |
| GO:0051127 | positive regulation of actin nucleation | 9.2308 | 7 | yes |
| GO:0051258 | protein polymerization | 9.2308 | 6 | yes |
| GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation | 9.2308 | 8 | yes |
| GO:0090287 | regulation of cellular response to growth factor stimulus | 7.6923 | 4 | yes |
| GO:0099563 | modification of synaptic structure | 7.6923 | 6 | yes |
| GO:1990138 | neuron projection extension | 7.6923 | 4 | yes |
| GO:0098657 | import into cell | 6.1538 | 4 | yes |
| GO:0098885 | modification of postsynaptic actin cytoskeleton | 6.1538 | 8 | yes |
| GO:0099010 | modification of postsynaptic structure | 6.1538 | 7 | yes |
| GO:0051386 | regulation of neurotrophin TRK receptor signaling pathway | 4.6154 | 5 | yes |
| GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway | 4.6154 | 6 | yes |
| GO:0072673 | lamellipodium morphogenesis | 4.6154 | 5 | yes |
| GO:0097484 | dendrite extension | 4.6154 | 5 | yes |
| GO:0006898 | receptor-mediated endocytosis | 3.0769 | 4 | yes |
| GO:1990089 | response to nerve growth factor | 3.0769 | 4 | yes |
| GO:1990090 | cellular response to nerve growth factor stimulus | 3.0769 | 5 | yes |
| GO:1990416 | cellular response to brain-derived neurotrophic factor stimulus | 3.0769 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ABI2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NCKP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| BSN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTN12_HUMAN | [view interactions] | Low throughput | no | yes |
| HXK4_HUMAN | [view interactions] | Low throughput | no | yes |
| BAD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NYAP2_HUMAN | [view interactions] | Low throughput | no | no |
| PR40A_HUMAN | [view interactions] | Low throughput | no | no |
| KAP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MAPK2_HUMAN | [view interactions] | Low throughput | no | yes |
| BAIP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SRBS2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GBB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNAI3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ARPC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ABI1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PROF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ABL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PROF2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BRK1_HUMAN | [view interactions] | Low throughput | no | no |
| FNBP1_HUMAN | [view interactions] | High throughput | no | yes |
| CIP4_HUMAN | [view interactions] | High throughput | no | no |
| P85A_HUMAN | [view interactions] | High throughput | no | yes |
| HOME1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSF2B_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF2_HUMAN | [view interactions] | High throughput | no | yes |
| ING5_HUMAN | [view interactions] | High throughput | no | yes |
| EFHC1_HUMAN | [view interactions] | High throughput | no | yes |
| ABI3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| ITF2_HUMAN | [view interactions] | High throughput | no | yes |
| AIPL1_HUMAN | [view interactions] | High throughput | no | no |
| IFT20_HUMAN | [view interactions] | High throughput | no | yes |
| MED20_HUMAN | [view interactions] | High throughput | no | no |
| PTPRE_HUMAN | [view interactions] | High throughput | no | no |
| EPHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| KCNK3_HUMAN | [view interactions] | High throughput | no | no |
| NXN_HUMAN | [view interactions] | High throughput | no | no |
| CAD23_HUMAN | [view interactions] | High throughput | no | yes |
| OSTF1_HUMAN | [view interactions] | High throughput | no | yes |
| RBTN2_HUMAN | [view interactions] | High throughput | no | yes |
| DNMBP_HUMAN | [view interactions] | High throughput | no | no |
| RYK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN511_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| LNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN746_HUMAN | [view interactions] | High throughput | no | no |
| TIM50_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NYAP1_HUMAN | [view interactions] | High throughput | no | no |
| MYO16_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKT3_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| RHG12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPDZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NHSL3_HUMAN | [view interactions] | High throughput | no | yes |
| NCK1_HUMAN | [view interactions] | High throughput | no | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KC1G3_HUMAN | [view interactions] | High throughput | no | yes |
| WASF3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WASF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| ZC3HF_HUMAN | [view interactions] | High throughput | no | yes |
| TXND9_HUMAN | [view interactions] | High throughput | no | yes |
| FBP1L_HUMAN | [view interactions] | High throughput | no | yes |
| WASL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARHG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRGP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARL4C_HUMAN | [view interactions] | High throughput | no | yes |
| BRSK2_HUMAN | [view interactions] | High throughput | no | no |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NTRK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTK7_HUMAN | [view interactions] | High throughput | no | yes |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NHSL1_HUMAN | [view interactions] | High throughput | no | yes |
| NCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATC2_HUMAN | [view interactions] | High throughput | no | yes |
| WASC3_HUMAN | [view interactions] | High throughput | no | yes |
| CBLC_HUMAN | [view interactions] | High throughput | no | yes |
| NHSL2_HUMAN | [view interactions] | High throughput | no | yes |
| AMZ1_HUMAN | [view interactions] | High throughput | no | no |
| CGB2_HUMAN | [view interactions] | High throughput | no | no |
| UBX11_HUMAN | [view interactions] | High throughput | no | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCD10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |