WASF1_HUMAN
Evidence for PS localization
Functions
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation (PubMed). The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex . As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes . Also involved in the regulation of mitochondrial dynamics (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI001663 | LIG_Actin_WH2_1 | LIG | 498 | 514 | - |
| ELMI003408 | LIG_PROFILIN_1 | LIG | 326 | 332 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in WASF1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 32.3529 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 30.8824 | 4 | no |
| GO:0019900 | kinase binding | 29.4118 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 29.4118 | 4 | no |
| GO:0003779 | actin binding | 27.9412 | 4 | yes |
| GO:0019901 | protein kinase binding | 26.4706 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 22.0588 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 20.5882 | 5 | no |
| GO:0034237 | protein kinase A regulatory subunit binding | 5.8824 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in WASF1_HUMAN |
|---|---|---|---|---|
| GO:0051128 | regulation of cellular component organization | 70.5882 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 69.1176 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 52.9412 | 4 | no |
| GO:0033043 | regulation of organelle organization | 51.4706 | 5 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 51.4706 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 50.0000 | 6 | yes |
| GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 48.5294 | 4 | yes |
| GO:0022607 | cellular component assembly | 48.5294 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 48.5294 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 48.5294 | 4 | no |
| GO:0006996 | organelle organization | 45.5882 | 4 | yes |
| GO:0032956 | regulation of actin cytoskeleton organization | 44.1176 | 5 | yes |
| GO:0032970 | regulation of actin filament-based process | 44.1176 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 42.6471 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 42.6471 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 42.6471 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 41.1765 | 4 | no |
| GO:0030030 | cell projection organization | 39.7059 | 4 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 38.2353 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 38.2353 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 38.2353 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 38.2353 | 6 | no |
| GO:0110053 | regulation of actin filament organization | 36.7647 | 6 | yes |
| GO:0051246 | regulation of protein metabolic process | 35.2941 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 35.2941 | 5 | no |
| GO:0007010 | cytoskeleton organization | 33.8235 | 5 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 33.8235 | 5 | yes |
| GO:0051049 | regulation of transport | 33.8235 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 33.8235 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 33.8235 | 5 | no |
| GO:0007015 | actin filament organization | 32.3529 | 5 | yes |
| GO:0010638 | positive regulation of organelle organization | 32.3529 | 6 | yes |
| GO:0097435 | supramolecular fiber organization | 32.3529 | 4 | yes |
| GO:0008104 | protein localization | 32.3529 | 4 | no |
| GO:0071310 | cellular response to organic substance | 30.8824 | 4 | yes |
| GO:0010468 | regulation of gene expression | 30.8824 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 30.8824 | 7 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 30.8824 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 29.4118 | 4 | yes |
| GO:0031399 | regulation of protein modification process | 29.4118 | 6 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 29.4118 | 5 | no |
| GO:0051495 | positive regulation of cytoskeleton organization | 27.9412 | 7 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 27.9412 | 4 | no |
| GO:0030334 | regulation of cell migration | 27.9412 | 5 | no |
| GO:2000145 | regulation of cell motility | 27.9412 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 27.9412 | 4 | no |
| GO:1902905 | positive regulation of supramolecular fiber organization | 26.4706 | 6 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 26.4706 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 25.0000 | 5 | yes |
| GO:0016192 | vesicle-mediated transport | 25.0000 | 4 | yes |
| GO:0023056 | positive regulation of signaling | 25.0000 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 25.0000 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.0000 | 5 | no |
| GO:0031346 | positive regulation of cell projection organization | 25.0000 | 6 | no |
| GO:0001932 | regulation of protein phosphorylation | 25.0000 | 7 | no |
| GO:0009889 | regulation of biosynthetic process | 25.0000 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 25.0000 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.0000 | 5 | no |
| GO:0030031 | cell projection assembly | 23.5294 | 5 | no |
| GO:0032535 | regulation of cellular component size | 23.5294 | 4 | no |
| GO:0043254 | regulation of protein-containing complex assembly | 23.5294 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 23.5294 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 23.5294 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 22.0588 | 5 | yes |
| GO:0032990 | cell part morphogenesis | 22.0588 | 4 | yes |
| GO:0034330 | cell junction organization | 22.0588 | 4 | yes |
| GO:0048858 | cell projection morphogenesis | 22.0588 | 5 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 22.0588 | 6 | yes |
| GO:0010975 | regulation of neuron projection development | 22.0588 | 7 | no |
| GO:0060491 | regulation of cell projection assembly | 22.0588 | 5 | no |
| GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 22.0588 | 6 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 22.0588 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 22.0588 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 22.0588 | 6 | no |
| GO:0032271 | regulation of protein polymerization | 22.0588 | 6 | no |
| GO:0042127 | regulation of cell population proliferation | 22.0588 | 4 | no |
| GO:0042327 | positive regulation of phosphorylation | 22.0588 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 22.0588 | 7 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 22.0588 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 22.0588 | 4 | no |
| GO:0036211 | protein modification process | 22.0588 | 4 | no |
| GO:0043412 | macromolecule modification | 22.0588 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 22.0588 | 5 | no |
| GO:0071417 | cellular response to organonitrogen compound | 22.0588 | 4 | no |
| GO:1901699 | cellular response to nitrogen compound | 22.0588 | 4 | no |
| GO:0051338 | regulation of transferase activity | 22.0588 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 22.0588 | 4 | no |
| GO:0060341 | regulation of cellular localization | 20.5882 | 4 | no |
| GO:0010941 | regulation of cell death | 20.5882 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 20.5882 | 5 | no |
| GO:0045597 | positive regulation of cell differentiation | 20.5882 | 5 | no |
| GO:0080134 | regulation of response to stress | 20.5882 | 4 | no |
| GO:0043933 | protein-containing complex organization | 19.1176 | 4 | yes |
| GO:0007264 | small GTPase mediated signal transduction | 17.6471 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 17.6471 | 5 | yes |
| GO:0006897 | endocytosis | 16.1765 | 5 | yes |
| GO:0007265 | Ras protein signal transduction | 16.1765 | 5 | yes |
| GO:0008154 | actin polymerization or depolymerization | 14.7059 | 6 | yes |
| GO:0050808 | synapse organization | 14.7059 | 5 | yes |
| GO:0034315 | regulation of Arp2/3 complex-mediated actin nucleation | 11.7647 | 8 | yes |
| GO:0051125 | regulation of actin nucleation | 11.7647 | 7 | yes |
| GO:0070848 | response to growth factor | 11.7647 | 4 | yes |
| GO:0097581 | lamellipodium organization | 11.7647 | 6 | yes |
| GO:0016601 | Rac protein signal transduction | 10.2941 | 6 | yes |
| GO:0030041 | actin filament polymerization | 10.2941 | 7 | yes |
| GO:0051127 | positive regulation of actin nucleation | 10.2941 | 7 | yes |
| GO:0051258 | protein polymerization | 10.2941 | 6 | yes |
| GO:0099563 | modification of synaptic structure | 10.2941 | 6 | yes |
| GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation | 10.2941 | 8 | yes |
| GO:0071363 | cellular response to growth factor stimulus | 8.8235 | 5 | yes |
| GO:0007005 | mitochondrion organization | 5.8824 | 5 | yes |
| GO:0090287 | regulation of cellular response to growth factor stimulus | 5.8824 | 4 | yes |
| GO:0098885 | modification of postsynaptic actin cytoskeleton | 5.8824 | 8 | yes |
| GO:0099010 | modification of postsynaptic structure | 5.8824 | 7 | yes |
| GO:1990138 | neuron projection extension | 5.8824 | 4 | yes |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 4.4118 | 4 | yes |
| GO:0051386 | regulation of neurotrophin TRK receptor signaling pathway | 4.4118 | 5 | yes |
| GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway | 4.4118 | 6 | yes |
| GO:0072673 | lamellipodium morphogenesis | 4.4118 | 7 | yes |
| GO:0097484 | dendrite extension | 4.4118 | 5 | yes |
| GO:0006898 | receptor-mediated endocytosis | 2.9412 | 6 | yes |
| GO:0010970 | transport along microtubule | 2.9412 | 4 | yes |
| GO:0072384 | organelle transport along microtubule | 2.9412 | 4 | yes |
| GO:0099111 | microtubule-based transport | 2.9412 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| BAIP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SRBS2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GBB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GNAI3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARPC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ABI1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PROF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ABL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PROF2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BRK1_HUMAN | [view interactions] | Low throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| BSN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NCKP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ABI2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTN12_HUMAN | [view interactions] | Low throughput | no | yes |
| HXK4_HUMAN | [view interactions] | Low throughput | no | yes |
| BAD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NYAP2_HUMAN | [view interactions] | Low throughput | no | no |
| PR40A_HUMAN | [view interactions] | Low throughput | no | yes |
| KAP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MAPK2_HUMAN | [view interactions] | Low throughput | no | yes |
| NHSL1_HUMAN | [view interactions] | High throughput | no | yes |
| NCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATC2_HUMAN | [view interactions] | High throughput | no | yes |
| WASC3_HUMAN | [view interactions] | High throughput | no | yes |
| CBLC_HUMAN | [view interactions] | High throughput | no | yes |
| NHSL2_HUMAN | [view interactions] | High throughput | no | yes |
| AMZ1_HUMAN | [view interactions] | High throughput | no | no |
| CGB2_HUMAN | [view interactions] | High throughput | no | no |
| UBX11_HUMAN | [view interactions] | High throughput | no | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCD10_HUMAN | [view interactions] | High throughput | no | yes |
| FNBP1_HUMAN | [view interactions] | High throughput | no | yes |
| CIP4_HUMAN | [view interactions] | High throughput | no | no |
| P85A_HUMAN | [view interactions] | High throughput | no | yes |
| HOME1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSF2B_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF2_HUMAN | [view interactions] | High throughput | no | yes |
| ING5_HUMAN | [view interactions] | High throughput | no | yes |
| EFHC1_HUMAN | [view interactions] | High throughput | no | yes |
| ABI3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| ITF2_HUMAN | [view interactions] | High throughput | no | yes |
| AIPL1_HUMAN | [view interactions] | High throughput | no | no |
| IFT20_HUMAN | [view interactions] | High throughput | no | yes |
| MED20_HUMAN | [view interactions] | High throughput | no | no |
| PTPRE_HUMAN | [view interactions] | High throughput | no | no |
| EPHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NXN_HUMAN | [view interactions] | High throughput | no | no |
| CAD23_HUMAN | [view interactions] | High throughput | no | yes |
| OSTF1_HUMAN | [view interactions] | High throughput | no | yes |
| RBTN2_HUMAN | [view interactions] | High throughput | no | yes |
| DNMBP_HUMAN | [view interactions] | High throughput | no | no |
| RYK_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN511_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| LNX1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN746_HUMAN | [view interactions] | High throughput | no | no |
| TIM50_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NYAP1_HUMAN | [view interactions] | High throughput | no | no |
| MYO16_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKT3_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| RHG12_HUMAN | [view interactions] | High throughput | no | yes |
| MPDZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1522_HUMAN | [view interactions] | High throughput | no | yes |
| NCK1_HUMAN | [view interactions] | High throughput | no | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KC1G3_HUMAN | [view interactions] | High throughput | no | yes |
| WASF3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WASF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZC3HF_HUMAN | [view interactions] | High throughput | no | yes |
| TXND9_HUMAN | [view interactions] | High throughput | no | yes |
| FBP1L_HUMAN | [view interactions] | High throughput | no | yes |
| WASL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARHG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRGP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARF1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| B2CL1_HUMAN | [view interactions] | Computational | no | yes |
| WIPF3_HUMAN | [view interactions] | Computational | no | yes |
| ARP2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SRGP2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| NCKPL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ARC1A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ARC1B_HUMAN | [view interactions] | Computational | no | no |
| NOE1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| MK03_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SPN90_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CDC42_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NCF1_HUMAN | [view interactions] | Computational | no | no |
| ARPC4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| WIPF1_HUMAN | [view interactions] | Computational | no | no |
| MK01_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ARPC3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ARPC5_HUMAN | [view interactions] | Computational | no | yes |
| WASP_HUMAN | [view interactions] | Computational | no | yes |
| WIPF2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |