NMDE2_HUMAN
Evidence for PS localization
Functions
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed, PubMed, PubMed, PubMed). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed, PubMed). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Contributes to neural pattern formation in the developing brain. Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NMDE2_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 32.6923 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 30.7692 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 30.7692 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 29.4872 | 4 | no |
| GO:0019900 | kinase binding | 24.3590 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 24.3590 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 24.3590 | 5 | no |
| GO:0005524 | ATP binding | 23.0769 | 5 | no |
| GO:0019901 | protein kinase binding | 21.7949 | 5 | no |
| GO:0016301 | kinase activity | 21.7949 | 4 | no |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 20.5128 | 4 | no |
| GO:0005216 | ion channel activity | 14.1026 | 4 | yes |
| GO:0015267 | channel activity | 14.1026 | 4 | yes |
| GO:0022836 | gated channel activity | 13.4615 | 5 | yes |
| GO:0008324 | cation transmembrane transporter activity | 12.8205 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 12.8205 | 4 | yes |
| GO:0005261 | cation channel activity | 12.1795 | 5 | yes |
| GO:0008066 | glutamate receptor activity | 11.5385 | 4 | yes |
| GO:0005230 | extracellular ligand-gated ion channel activity | 10.2564 | 6 | yes |
| GO:0015276 | ligand-gated ion channel activity | 10.2564 | 5 | yes |
| GO:0022824 | transmitter-gated ion channel activity | 10.2564 | 5 | yes |
| GO:0022834 | ligand-gated channel activity | 10.2564 | 6 | yes |
| GO:0022835 | transmitter-gated channel activity | 10.2564 | 4 | yes |
| GO:0004970 | ionotropic glutamate receptor activity | 9.6154 | 5 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 8.9744 | 5 | yes |
| GO:0005244 | voltage-gated ion channel activity | 8.3333 | 4 | yes |
| GO:0005262 | calcium channel activity | 8.3333 | 6 | yes |
| GO:0015085 | calcium ion transmembrane transporter activity | 8.3333 | 6 | yes |
| GO:0022832 | voltage-gated channel activity | 8.3333 | 6 | yes |
| GO:0022843 | voltage-gated cation channel activity | 8.3333 | 5 | yes |
| GO:0046914 | transition metal ion binding | 8.3333 | 5 | yes |
| GO:0099094 | ligand-gated cation channel activity | 8.3333 | 6 | yes |
| GO:0001540 | amyloid-beta binding | 6.4103 | 4 | yes |
| GO:0008270 | zinc ion binding | 6.4103 | 6 | yes |
| GO:0031406 | carboxylic acid binding | 5.7692 | 4 | yes |
| GO:0004972 | NMDA glutamate receptor activity | 5.1282 | 6 | yes |
| GO:0016597 | amino acid binding | 5.1282 | 4 | yes |
| GO:0022849 | glutamate-gated calcium ion channel activity | 3.8462 | 6 | yes |
| GO:0099604 | ligand-gated calcium channel activity | 3.8462 | 7 | yes |
| GO:0016594 | glycine binding | 3.2051 | 4 | yes |
| GO:0016595 | glutamate binding | 3.2051 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NMDE2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 66.6667 | 4 | yes |
| GO:0010646 | regulation of cell communication | 64.7436 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 51.9231 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 51.2821 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 50.6410 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 48.0769 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 47.4359 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 47.4359 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 46.7949 | 4 | no |
| GO:0051049 | regulation of transport | 46.7949 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 41.0256 | 5 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 39.1026 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 39.1026 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 38.4615 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 37.8205 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 37.8205 | 4 | yes |
| GO:0008104 | protein localization | 37.8205 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 36.5385 | 5 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 35.8974 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 32.6923 | 6 | yes |
| GO:0022607 | cellular component assembly | 32.0513 | 4 | yes |
| GO:0010468 | regulation of gene expression | 32.0513 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 32.0513 | 4 | no |
| GO:0031399 | regulation of protein modification process | 32.0513 | 6 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 31.4103 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.7692 | 5 | no |
| GO:0010941 | regulation of cell death | 30.1282 | 4 | yes |
| GO:0036211 | protein modification process | 28.8462 | 4 | no |
| GO:0043412 | macromolecule modification | 28.8462 | 4 | no |
| GO:0060341 | regulation of cellular localization | 28.2051 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 28.2051 | 7 | no |
| GO:0019220 | regulation of phosphate metabolic process | 28.2051 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 28.2051 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 28.2051 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 28.2051 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 27.5641 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 27.5641 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.5641 | 5 | no |
| GO:0071702 | organic substance transport | 26.9231 | 4 | no |
| GO:0006996 | organelle organization | 26.9231 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 26.9231 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 26.2821 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 26.2821 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 25.6410 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 25.6410 | 5 | no |
| GO:0071705 | nitrogen compound transport | 25.6410 | 4 | no |
| GO:0043269 | regulation of ion transport | 25.6410 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 25.0000 | 7 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 24.3590 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 24.3590 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 23.7179 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 23.7179 | 5 | no |
| GO:0023057 | negative regulation of signaling | 23.7179 | 4 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 23.7179 | 8 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 23.7179 | 6 | no |
| GO:0042327 | positive regulation of phosphorylation | 23.7179 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 23.7179 | 7 | no |
| GO:0099537 | trans-synaptic signaling | 23.0769 | 4 | yes |
| GO:0032880 | regulation of protein localization | 23.0769 | 5 | no |
| GO:0051050 | positive regulation of transport | 23.0769 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 23.0769 | 4 | no |
| GO:0033043 | regulation of organelle organization | 23.0769 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.4359 | 5 | no |
| GO:0034762 | regulation of transmembrane transport | 22.4359 | 4 | no |
| GO:0007268 | chemical synaptic transmission | 21.7949 | 6 | yes |
| GO:0043933 | protein-containing complex organization | 21.7949 | 4 | yes |
| GO:0051336 | regulation of hydrolase activity | 21.7949 | 4 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 21.7949 | 5 | yes |
| GO:0015031 | protein transport | 21.7949 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 21.7949 | 4 | no |
| GO:0071310 | cellular response to organic substance | 21.7949 | 4 | no |
| GO:0016310 | phosphorylation | 21.7949 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 21.1538 | 6 | no |
| GO:0051338 | regulation of transferase activity | 21.1538 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 21.1538 | 4 | no |
| GO:0009894 | regulation of catabolic process | 21.1538 | 4 | no |
| GO:0006468 | protein phosphorylation | 21.1538 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 20.5128 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 20.5128 | 5 | no |
| GO:0034765 | regulation of ion transmembrane transport | 20.5128 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 19.2308 | 5 | yes |
| GO:0031344 | regulation of cell projection organization | 18.5897 | 5 | yes |
| GO:0006811 | ion transport | 17.9487 | 4 | yes |
| GO:0050890 | cognition | 17.9487 | 4 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 17.9487 | 6 | yes |
| GO:0030162 | regulation of proteolysis | 16.6667 | 6 | yes |
| GO:0006812 | cation transport | 15.3846 | 5 | yes |
| GO:0050806 | positive regulation of synaptic transmission | 15.3846 | 5 | yes |
| GO:0030001 | metal ion transport | 13.4615 | 6 | yes |
| GO:0051129 | negative regulation of cellular component organization | 13.4615 | 5 | yes |
| GO:0010942 | positive regulation of cell death | 12.8205 | 5 | yes |
| GO:0051345 | positive regulation of hydrolase activity | 12.8205 | 5 | yes |
| GO:0050807 | regulation of synapse organization | 12.1795 | 5 | yes |
| GO:1901214 | regulation of neuron death | 12.1795 | 5 | yes |
| GO:0007215 | glutamate receptor signaling pathway | 11.5385 | 4 | yes |
| GO:0006816 | calcium ion transport | 10.2564 | 7 | yes |
| GO:0045862 | positive regulation of proteolysis | 10.2564 | 7 | yes |
| GO:0052547 | regulation of peptidase activity | 9.6154 | 5 | yes |
| GO:0007420 | brain development | 8.9744 | 4 | yes |
| GO:0052548 | regulation of endopeptidase activity | 8.9744 | 6 | yes |
| GO:0099175 | regulation of postsynapse organization | 8.9744 | 6 | yes |
| GO:2000116 | regulation of cysteine-type endopeptidase activity | 8.9744 | 7 | yes |
| GO:0060291 | long-term synaptic potentiation | 8.3333 | 4 | yes |
| GO:0097305 | response to alcohol | 7.6923 | 4 | yes |
| GO:0060078 | regulation of postsynaptic membrane potential | 7.0513 | 4 | yes |
| GO:0060079 | excitatory postsynaptic potential | 7.0513 | 5 | yes |
| GO:0010950 | positive regulation of endopeptidase activity | 6.4103 | 7 | yes |
| GO:0010952 | positive regulation of peptidase activity | 6.4103 | 6 | yes |
| GO:0098655 | cation transmembrane transport | 6.4103 | 4 | yes |
| GO:0098660 | inorganic ion transmembrane transport | 6.4103 | 4 | yes |
| GO:0098662 | inorganic cation transmembrane transport | 6.4103 | 5 | yes |
| GO:2001056 | positive regulation of cysteine-type endopeptidase activity | 6.4103 | 8 | yes |
| GO:0051259 | protein complex oligomerization | 5.7692 | 6 | yes |
| GO:0031345 | negative regulation of cell projection organization | 5.1282 | 6 | yes |
| GO:0045471 | response to ethanol | 5.1282 | 5 | yes |
| GO:1901216 | positive regulation of neuron death | 5.1282 | 6 | yes |
| GO:0070588 | calcium ion transmembrane transport | 4.4872 | 6 | yes |
| GO:0097553 | calcium ion transmembrane import into cytosol | 4.4872 | 7 | yes |
| GO:0051262 | protein tetramerization | 3.8462 | 7 | yes |
| GO:0098976 | excitatory chemical synaptic transmission | 3.8462 | 7 | yes |
| GO:1902950 | regulation of dendritic spine maintenance | 3.2051 | 7 | yes |
| GO:1902951 | negative regulation of dendritic spine maintenance | 2.5641 | 7 | yes |
| GO:0051290 | protein heterotetramerization | 1.9231 | 8 | yes |
| GO:0051291 | protein heterooligomerization | 1.9231 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in NMDE2_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 4.4872 | 3 | no |
| DOID:0050700 | cardiomyopathy | 3.2051 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 3.2051 | 5 | no |
| DOID:114 | heart disease | 3.2051 | 3 | no |
| DOID:1289 | neurodegenerative disease | 3.2051 | 4 | no |
| DOID:2843 | long QT syndrome | 1.9231 | 6 | no |
| DOID:936 | brain disease | 1.9231 | 4 | no |
| DOID:0050753 | cerebellar ataxia | 1.2821 | 6 | no |
| DOID:0050950 | autosomal recessive cerebellar ataxia | 1.2821 | 7 | no |
| DOID:0050951 | hereditary ataxia | 1.2821 | 5 | no |
| DOID:0060038 | specific developmental disorder | 1.2821 | 3 | no |
| DOID:1059 | intellectual disability | 1.2821 | 4 | no |
| DOID:12930 | dilated cardiomyopathy | 1.2821 | 6 | no |
| DOID:231 | motor neuron disease | 1.2821 | 5 | no |
| DOID:332 | amyotrophic lateral sclerosis | 1.2821 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RGRF1_HUMAN | [view interactions] | Low throughput | no | yes |
| AP1M1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP4M1_HUMAN | [view interactions] | Low throughput | no | yes |
| RACK1_HUMAN | [view interactions] | Low throughput | no | yes |
| AKAP5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MIB2_HUMAN | [view interactions] | Low throughput | no | yes |
| KPCB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCG_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TANC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHC2_HUMAN | [view interactions] | Low throughput | no | yes |
| SHC3_HUMAN | [view interactions] | Low throughput | no | yes |
| FAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCC2G_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PDE10_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| APLP1_HUMAN | [view interactions] | Low throughput | no | yes |
| APLP2_HUMAN | [view interactions] | Low throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| PRR7_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NMD3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SYUA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MAP1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EXOC7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ERBIN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LIN7A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CSK21_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCC2D_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CSK22_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CSK2B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LRP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRIC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| AP2B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IQEC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IQEC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RIMS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RB11B_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DLG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MAGI3_HUMAN | [view interactions] | Low throughput | no | no |
| INADL_HUMAN | [view interactions] | Low throughput | no | no |
| NMDZ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LIN7B_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DLG3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DAPK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACTN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCC2B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMDE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LRRC7_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| AP2A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NETO1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DPYL2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| APC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PTN5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MET_HUMAN | [view interactions] | Low throughput | no | yes |
| RHG32_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLGP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EXOC4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KDM5B_HUMAN | [view interactions] | High throughput | no | no |
| NOS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HOME1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKAP9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP2AA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MP2K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MP2K2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KS6A1_HUMAN | [view interactions] | High throughput | no | yes |
| KS6A3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RALA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P85A_HUMAN | [view interactions] | High throughput | no | yes |
| PLCG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PA24A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CADH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DSG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MTAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| SPTA1_HUMAN | [view interactions] | High throughput | no | no |
| SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIN7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KALRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EAA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| GRID1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GRID2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EPS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VANG2_HUMAN | [view interactions] | High throughput | no | no |
| NSF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTN11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP2BA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TP53B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZO1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AINX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DP13A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BSN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PFKAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GRM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRFN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| IL16_HUMAN | [view interactions] | High throughput | no | no |
| PTPRC_HUMAN | [view interactions] | High throughput | no | no |
| PTPRG_HUMAN | [view interactions] | High throughput | no | no |
| PTPRB_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRJ_HUMAN | [view interactions] | High throughput | no | yes |
| PTN12_HUMAN | [view interactions] | High throughput | no | yes |
| CAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCRIB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NRG1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GRIA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CCG2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GRIA3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PDYN_HUMAN | [view interactions] | Computational | no | yes |
| RELN_HUMAN | [view interactions] | Computational | no | no |
| GRIA2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GRIA4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CCG3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| MPDZ_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KAPCG_HUMAN | [view interactions] | Computational | no | no |
| SHAN1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MECP2_HUMAN | [view interactions] | Computational | no | yes |
| KIF17_HUMAN | [view interactions] | Computational | no | no |
| NMDE4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NMDE3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CCG8_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| NTRK2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GRM5_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| LRP8_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| APBA1_HUMAN | [view interactions] | Computational | no | no |
| BDNF_HUMAN | [view interactions] | Computational | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DAB1_HUMAN | [view interactions] | Computational | no | yes |
| RASN_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| 5HT3A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| NMD3B_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GRM3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PP1B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DRD2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CCG7_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CDK5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KAPCB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ERBB4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |