NMDE2_HUMAN
Evidence for PS localization
Functions
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed, PubMed, PubMed, PubMed). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed, PubMed). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Contributes to neural pattern formation in the developing brain. Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NMDE2_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 37.6623 | 4 | yes |
| GO:0043169 | cation binding | 35.7143 | 4 | yes |
| GO:0046872 | metal ion binding | 34.4156 | 5 | yes |
| GO:0000166 | nucleotide binding | 31.8182 | 4 | no |
| GO:0017076 | purine nucleotide binding | 31.8182 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 31.1688 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 29.8701 | 4 | no |
| GO:0019900 | kinase binding | 25.9740 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 25.9740 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 25.3247 | 5 | no |
| GO:0005524 | ATP binding | 24.0260 | 5 | no |
| GO:0019901 | protein kinase binding | 22.0779 | 5 | no |
| GO:0016301 | kinase activity | 21.4286 | 4 | no |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 20.1299 | 4 | no |
| GO:0046914 | transition metal ion binding | 9.0909 | 6 | yes |
| GO:0008270 | zinc ion binding | 7.1429 | 7 | yes |
| GO:0005216 | monoatomic ion channel activity | 6.4935 | 4 | yes |
| GO:0008066 | glutamate receptor activity | 6.4935 | 4 | yes |
| GO:0015267 | channel activity | 6.4935 | 4 | yes |
| GO:0046943 | carboxylic acid transmembrane transporter activity | 6.4935 | 4 | yes |
| GO:0004970 | glutamate-gated receptor activity | 5.8442 | 4 | yes |
| GO:0005230 | extracellular ligand-gated monoatomic ion channel activity | 5.8442 | 6 | yes |
| GO:0015276 | ligand-gated monoatomic ion channel activity | 5.8442 | 5 | yes |
| GO:0022824 | transmitter-gated monoatomic ion channel activity | 5.8442 | 5 | yes |
| GO:0022834 | ligand-gated channel activity | 5.8442 | 6 | yes |
| GO:0022835 | transmitter-gated channel activity | 5.8442 | 4 | yes |
| GO:0022836 | gated channel activity | 5.8442 | 5 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 5.8442 | 4 | yes |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 5.1948 | 4 | yes |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 4.5455 | 4 | yes |
| GO:0031406 | carboxylic acid binding | 4.5455 | 4 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 4.5455 | 5 | yes |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 4.5455 | 5 | yes |
| GO:1904315 | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential | 4.5455 | 6 | yes |
| GO:0004972 | NMDA glutamate receptor activity | 3.8961 | 5 | yes |
| GO:0005244 | voltage-gated monoatomic ion channel activity | 3.8961 | 5 | yes |
| GO:0015085 | calcium ion transmembrane transporter activity | 3.8961 | 6 | yes |
| GO:0022832 | voltage-gated channel activity | 3.8961 | 6 | yes |
| GO:0005261 | monoatomic cation channel activity | 3.2468 | 5 | yes |
| GO:0005262 | calcium channel activity | 3.2468 | 6 | yes |
| GO:0022849 | glutamate-gated calcium ion channel activity | 2.5974 | 5 | yes |
| GO:0099094 | ligand-gated monoatomic cation channel activity | 2.5974 | 6 | yes |
| GO:0099604 | ligand-gated calcium channel activity | 2.5974 | 7 | yes |
| GO:0099507 | ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential | 1.2987 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NMDE2_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 66.8831 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 62.9870 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 51.2987 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 51.2987 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 51.2987 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 45.4545 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 43.5065 | 4 | no |
| GO:0051049 | regulation of transport | 42.8571 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 42.2078 | 4 | yes |
| GO:0008104 | protein localization | 37.6623 | 4 | no |
| GO:0023056 | positive regulation of signaling | 37.0130 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 35.7143 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 35.0649 | 4 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 34.4156 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 34.4156 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 34.4156 | 5 | yes |
| GO:0022607 | cellular component assembly | 33.7662 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.1169 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 32.4675 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 32.4675 | 5 | yes |
| GO:0009967 | positive regulation of signal transduction | 29.8701 | 5 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 29.2208 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 29.2208 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 29.2208 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 29.2208 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 27.9221 | 5 | no |
| GO:0010468 | regulation of gene expression | 27.2727 | 6 | no |
| GO:0009892 | negative regulation of metabolic process | 26.6234 | 4 | no |
| GO:0006996 | organelle organization | 26.6234 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.9740 | 5 | no |
| GO:0071702 | organic substance transport | 25.9740 | 4 | no |
| GO:0036211 | protein modification process | 25.3247 | 4 | no |
| GO:0043412 | macromolecule modification | 25.3247 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 25.3247 | 5 | no |
| GO:0060341 | regulation of cellular localization | 25.3247 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.3247 | 6 | yes |
| GO:0071705 | nitrogen compound transport | 24.6753 | 4 | no |
| GO:0033043 | regulation of organelle organization | 24.6753 | 5 | no |
| GO:0031399 | regulation of protein modification process | 24.0260 | 6 | no |
| GO:0048585 | negative regulation of response to stimulus | 24.0260 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 23.3766 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 23.3766 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 23.3766 | 4 | no |
| GO:0141124 | intracellular signaling cassette | 22.7273 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 22.7273 | 5 | no |
| GO:0023057 | negative regulation of signaling | 22.7273 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.0779 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.0779 | 5 | no |
| GO:0015031 | protein transport | 22.0779 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 21.4286 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 21.4286 | 7 | no |
| GO:0042325 | regulation of phosphorylation | 21.4286 | 7 | no |
| GO:0099536 | synaptic signaling | 20.7792 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 20.7792 | 5 | yes |
| GO:0030030 | cell projection organization | 20.7792 | 4 | no |
| GO:0051050 | positive regulation of transport | 20.7792 | 4 | no |
| GO:0098916 | anterograde trans-synaptic signaling | 20.1299 | 6 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 20.1299 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 20.1299 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 20.1299 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 20.1299 | 4 | no |
| GO:0032880 | regulation of protein localization | 20.1299 | 5 | no |
| GO:0007268 | chemical synaptic transmission | 20.1299 | 7 | yes |
| GO:0031344 | regulation of cell projection organization | 20.1299 | 5 | yes |
| GO:0043085 | positive regulation of catalytic activity | 20.1299 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 20.1299 | 4 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 19.4805 | 6 | yes |
| GO:0034762 | regulation of transmembrane transport | 19.4805 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 18.8312 | 5 | yes |
| GO:0043269 | regulation of monoatomic ion transport | 18.1818 | 5 | yes |
| GO:0044057 | regulation of system process | 18.1818 | 4 | yes |
| GO:0051336 | regulation of hydrolase activity | 16.8831 | 4 | yes |
| GO:0050890 | cognition | 16.8831 | 4 | yes |
| GO:0050807 | regulation of synapse organization | 16.2338 | 5 | yes |
| GO:0034765 | regulation of monoatomic ion transmembrane transport | 14.9351 | 5 | yes |
| GO:0051129 | negative regulation of cellular component organization | 14.9351 | 5 | yes |
| GO:1904062 | regulation of monoatomic cation transmembrane transport | 14.2857 | 6 | yes |
| GO:0030162 | regulation of proteolysis | 14.2857 | 6 | yes |
| GO:0050806 | positive regulation of synaptic transmission | 12.9870 | 5 | yes |
| GO:0099175 | regulation of postsynapse organization | 11.6883 | 6 | yes |
| GO:0051345 | positive regulation of hydrolase activity | 11.0390 | 5 | yes |
| GO:0048168 | regulation of neuronal synaptic plasticity | 10.3896 | 4 | yes |
| GO:0006811 | monoatomic ion transport | 9.7403 | 4 | yes |
| GO:0006812 | monoatomic cation transport | 9.7403 | 5 | yes |
| GO:0030001 | metal ion transport | 9.7403 | 6 | yes |
| GO:0052547 | regulation of peptidase activity | 8.4416 | 5 | yes |
| GO:0045862 | positive regulation of proteolysis | 8.4416 | 7 | yes |
| GO:0052548 | regulation of endopeptidase activity | 7.7922 | 6 | yes |
| GO:2000116 | regulation of cysteine-type endopeptidase activity | 7.7922 | 7 | yes |
| GO:0007215 | glutamate receptor signaling pathway | 7.7922 | 4 | yes |
| GO:0051966 | regulation of synaptic transmission, glutamatergic | 7.1429 | 6 | yes |
| GO:0060291 | long-term synaptic potentiation | 7.1429 | 4 | yes |
| GO:0097305 | response to alcohol | 7.1429 | 4 | yes |
| GO:0006816 | calcium ion transport | 7.1429 | 7 | yes |
| GO:0031644 | regulation of nervous system process | 7.1429 | 5 | yes |
| GO:0051259 | protein complex oligomerization | 6.4935 | 6 | yes |
| GO:0098815 | modulation of excitatory postsynaptic potential | 6.4935 | 4 | yes |
| GO:2000463 | positive regulation of excitatory postsynaptic potential | 5.8442 | 5 | yes |
| GO:0007420 | brain development | 5.8442 | 4 | yes |
| GO:0045471 | response to ethanol | 5.8442 | 5 | yes |
| GO:0035235 | ionotropic glutamate receptor signaling pathway | 5.1948 | 4 | yes |
| GO:0035249 | synaptic transmission, glutamatergic | 5.1948 | 8 | yes |
| GO:0051968 | positive regulation of synaptic transmission, glutamatergic | 4.5455 | 6 | yes |
| GO:0060078 | regulation of postsynaptic membrane potential | 4.5455 | 4 | yes |
| GO:0060079 | excitatory postsynaptic potential | 4.5455 | 5 | yes |
| GO:0098655 | monoatomic cation transmembrane transport | 4.5455 | 4 | yes |
| GO:0098662 | inorganic cation transmembrane transport | 4.5455 | 4 | yes |
| GO:2001056 | positive regulation of cysteine-type endopeptidase activity | 4.5455 | 8 | yes |
| GO:0010950 | positive regulation of endopeptidase activity | 4.5455 | 7 | yes |
| GO:0010952 | positive regulation of peptidase activity | 4.5455 | 6 | yes |
| GO:0051262 | protein tetramerization | 3.8961 | 7 | yes |
| GO:0070588 | calcium ion transmembrane transport | 3.8961 | 5 | yes |
| GO:0031345 | negative regulation of cell projection organization | 3.8961 | 6 | yes |
| GO:0097553 | calcium ion transmembrane import into cytosol | 3.2468 | 6 | yes |
| GO:0098976 | excitatory chemical synaptic transmission | 2.5974 | 8 | yes |
| GO:1902950 | regulation of dendritic spine maintenance | 2.5974 | 7 | yes |
| GO:0051290 | protein heterotetramerization | 1.9481 | 8 | yes |
| GO:0051291 | protein heterooligomerization | 1.9481 | 7 | yes |
| GO:1902951 | negative regulation of dendritic spine maintenance | 1.9481 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MAGI3_HUMAN | [view interactions] | Low throughput | no | no |
| INADL_HUMAN | [view interactions] | Low throughput | no | no |
| NMDZ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LIN7B_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DLG3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DAPK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMDE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCC2B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACTN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LRRC7_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| AP2A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NETO1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DPYL2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| APC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PTN5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MET_HUMAN | [view interactions] | Low throughput | no | yes |
| RHG32_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLGP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RGRF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP1M1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP4M1_HUMAN | [view interactions] | Low throughput | no | yes |
| RACK1_HUMAN | [view interactions] | Low throughput | no | yes |
| AKAP5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MIB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCG_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TANC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHC2_HUMAN | [view interactions] | Low throughput | no | yes |
| SHC3_HUMAN | [view interactions] | Low throughput | no | yes |
| FAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCC2G_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PDE10_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| APLP1_HUMAN | [view interactions] | Low throughput | no | yes |
| APLP2_HUMAN | [view interactions] | Low throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| PRR7_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NMD3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SYUA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MAP1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EXOC7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ERBIN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LIN7A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CSK21_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCC2D_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CSK22_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CSK2B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LRP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRIC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| AP2B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IQEC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RIMS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RB11B_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DLG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VANG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PFKAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BSN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DP13A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AINX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZO1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TP53B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP2BA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTN11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NSF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRFN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| IL16_HUMAN | [view interactions] | High throughput | no | no |
| PTPRC_HUMAN | [view interactions] | High throughput | no | no |
| PTPRG_HUMAN | [view interactions] | High throughput | no | no |
| PTPRB_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRJ_HUMAN | [view interactions] | High throughput | no | yes |
| PTN12_HUMAN | [view interactions] | High throughput | no | yes |
| CAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCRIB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EXOC4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KDM5B_HUMAN | [view interactions] | High throughput | no | no |
| NOS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HOME1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKAP9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP2AA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MP2K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MP2K2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KS6A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KS6A3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RALA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P85A_HUMAN | [view interactions] | High throughput | no | yes |
| PLCG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PA24A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CADH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DSG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MTAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| SPTA1_HUMAN | [view interactions] | High throughput | no | no |
| SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIN7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KALRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EAA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OTU7A_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| GRID1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GRID2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDKL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHCR7_HUMAN | [view interactions] | High throughput | no | yes |
| GRIA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEPT3_HUMAN | [view interactions] | High throughput | no | no |
| SEPT6_HUMAN | [view interactions] | High throughput | no | yes |
| SEPT8_HUMAN | [view interactions] | High throughput | no | no |
| AGRL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTNA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTND2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| DLGP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELFN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| E41L3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F1712_HUMAN | [view interactions] | High throughput | no | no |
| F171B_HUMAN | [view interactions] | High throughput | no | yes |
| MGLYR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2AY_HUMAN | [view interactions] | High throughput | no | yes |
| KCNB2_HUMAN | [view interactions] | High throughput | no | no |
| KCD12_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NCAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PCDH8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PEBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLPR3_HUMAN | [view interactions] | High throughput | no | no |
| PLPR4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PSD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDHA_HUMAN | [view interactions] | High throughput | no | yes |
| SGIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYT11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TEN4_HUMAN | [view interactions] | High throughput | no | no |
| UBAP2_HUMAN | [view interactions] | High throughput | no | yes |
| WASF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRC4C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAOK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |