Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PDE10_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PDE10_HUMAN
GO:0046872 metal ion binding 60.0000 4 yes
GO:0001664 G protein-coupled receptor binding 40.0000 4 no
GO:0019902 phosphatase binding 40.0000 4 no
GO:0004112 cyclic-nucleotide phosphodiesterase activity 30.0000 6 yes
GO:0004114 3,5-cyclic-nucleotide phosphodiesterase activity 30.0000 7 yes
GO:0004115 3,5-cyclic-AMP phosphodiesterase activity 30.0000 8 yes
GO:0008081 phosphoric diester hydrolase activity 30.0000 5 yes
GO:0017076 purine nucleotide binding 30.0000 4 yes
GO:0030554 adenyl nucleotide binding 30.0000 5 yes
GO:0032555 purine ribonucleotide binding 30.0000 4 yes
GO:0032559 adenyl ribonucleotide binding 30.0000 5 yes
GO:0042578 phosphoric ester hydrolase activity 30.0000 4 yes
GO:0047555 3,5-cyclic-GMP phosphodiesterase activity 30.0000 8 yes
GO:0019900 kinase binding 30.0000 4 no
GO:0019903 protein phosphatase binding 30.0000 5 no
GO:0035254 glutamate receptor binding 30.0000 4 no
GO:0001540 amyloid-beta binding 30.0000 4 no
GO:0046914 transition metal ion binding 30.0000 5 no
GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity 20.0000 8 yes
GO:0019001 guanyl nucleotide binding 20.0000 5 yes
GO:0030551 cyclic nucleotide binding 20.0000 4 yes
GO:0030552 cAMP binding 20.0000 4 yes
GO:0030553 cGMP binding 20.0000 4 yes
GO:0032561 guanyl ribonucleotide binding 20.0000 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PDE10_HUMAN
GO:0010646 regulation of cell communication 100.0000 4 yes
GO:0009966 regulation of signal transduction 80.0000 4 yes
GO:0048523 negative regulation of cellular process 80.0000 4 yes
GO:0048522 positive regulation of cellular process 80.0000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 70.0000 4 no
GO:0051246 regulation of protein metabolic process 70.0000 5 no
GO:0060255 regulation of macromolecule metabolic process 70.0000 4 no
GO:0080090 regulation of primary metabolic process 70.0000 4 no
GO:0050804 modulation of chemical synaptic transmission 70.0000 5 no
GO:0099177 regulation of trans-synaptic signaling 70.0000 4 no
GO:1902531 regulation of intracellular signal transduction 60.0000 5 yes
GO:0009893 positive regulation of metabolic process 60.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 60.0000 5 no
GO:0010647 positive regulation of cell communication 60.0000 5 no
GO:0023056 positive regulation of signaling 60.0000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 60.0000 5 no
GO:0051247 positive regulation of protein metabolic process 60.0000 6 no
GO:0043085 positive regulation of catalytic activity 60.0000 4 no
GO:0050890 cognition 60.0000 4 no
GO:0001932 regulation of protein phosphorylation 50.0000 7 no
GO:0019220 regulation of phosphate metabolic process 50.0000 6 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0031399 regulation of protein modification process 50.0000 6 no
GO:0042325 regulation of phosphorylation 50.0000 7 no
GO:0051174 regulation of phosphorus metabolic process 50.0000 5 no
GO:0007268 chemical synaptic transmission 50.0000 6 no
GO:0050806 positive regulation of synaptic transmission 50.0000 5 no
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0060341 regulation of cellular localization 50.0000 4 no
GO:0098916 anterograde trans-synaptic signaling 50.0000 5 no
GO:0099537 trans-synaptic signaling 50.0000 4 no
GO:0006796 phosphate-containing compound metabolic process 40.0000 4 yes
GO:0048585 negative regulation of response to stimulus 40.0000 4 yes
GO:0001934 positive regulation of protein phosphorylation 40.0000 8 no
GO:0010562 positive regulation of phosphorus metabolic process 40.0000 6 no
GO:0010941 regulation of cell death 40.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 40.0000 5 no
GO:0031401 positive regulation of protein modification process 40.0000 7 no
GO:0042327 positive regulation of phosphorylation 40.0000 8 no
GO:0045937 positive regulation of phosphate metabolic process 40.0000 7 no
GO:0071310 cellular response to organic substance 40.0000 4 no
GO:0022607 cellular component assembly 40.0000 4 no
GO:0032880 regulation of protein localization 40.0000 5 no
GO:0043933 protein-containing complex organization 40.0000 4 no
GO:0051049 regulation of transport 40.0000 4 no
GO:1903829 positive regulation of protein localization 40.0000 5 no
GO:1905475 regulation of protein localization to membrane 40.0000 6 no
GO:1905477 positive regulation of protein localization to membrane 40.0000 6 no
GO:0010243 response to organonitrogen compound 40.0000 4 no
GO:0006163 purine nucleotide metabolic process 30.0000 5 yes
GO:0006195 purine nucleotide catabolic process 30.0000 6 yes
GO:0006198 cAMP catabolic process 30.0000 7 yes
GO:0006753 nucleoside phosphate metabolic process 30.0000 4 yes
GO:0009117 nucleotide metabolic process 30.0000 5 yes
GO:0009150 purine ribonucleotide metabolic process 30.0000 6 yes
GO:0009154 purine ribonucleotide catabolic process 30.0000 6 yes
GO:0009166 nucleotide catabolic process 30.0000 6 yes
GO:0009187 cyclic nucleotide metabolic process 30.0000 6 yes
GO:0009214 cyclic nucleotide catabolic process 30.0000 7 yes
GO:0009259 ribonucleotide metabolic process 30.0000 5 yes
GO:0009261 ribonucleotide catabolic process 30.0000 5 yes
GO:0009968 negative regulation of signal transduction 30.0000 5 yes
GO:0010648 negative regulation of cell communication 30.0000 5 yes
GO:0019439 aromatic compound catabolic process 30.0000 4 yes
GO:0019693 ribose phosphate metabolic process 30.0000 4 yes
GO:0023057 negative regulation of signaling 30.0000 4 yes
GO:0034655 nucleobase-containing compound catabolic process 30.0000 4 yes
GO:0044270 cellular nitrogen compound catabolic process 30.0000 4 yes
GO:0046058 cAMP metabolic process 30.0000 7 yes
GO:0046434 organophosphate catabolic process 30.0000 4 yes
GO:0046700 heterocycle catabolic process 30.0000 4 yes
GO:0072521 purine-containing compound metabolic process 30.0000 4 yes
GO:0072523 purine-containing compound catabolic process 30.0000 5 yes
GO:1901136 carbohydrate derivative catabolic process 30.0000 4 yes
GO:1901292 nucleoside phosphate catabolic process 30.0000 5 yes
GO:1901361 organic cyclic compound catabolic process 30.0000 4 yes
GO:1901565 organonitrogen compound catabolic process 30.0000 4 yes
GO:1902532 negative regulation of intracellular signal transduction 30.0000 6 yes
GO:0009889 regulation of biosynthetic process 30.0000 4 no
GO:0010468 regulation of gene expression 30.0000 5 no
GO:0010556 regulation of macromolecule biosynthetic process 30.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 30.0000 5 no
GO:0048584 positive regulation of response to stimulus 30.0000 4 no
GO:0070848 response to growth factor 30.0000 4 no
GO:0007612 learning 30.0000 4 no
GO:0008104 protein localization 30.0000 4 no
GO:0010038 response to metal ion 30.0000 4 no
GO:0030030 cell projection organization 30.0000 4 no
GO:0031344 regulation of cell projection organization 30.0000 5 no
GO:0051129 negative regulation of cellular component organization 30.0000 5 no
GO:0051338 regulation of transferase activity 30.0000 4 no
GO:0051347 positive regulation of transferase activity 30.0000 5 no
GO:0060627 regulation of vesicle-mediated transport 30.0000 4 no
GO:0065003 protein-containing complex assembly 30.0000 5 no
GO:0071241 cellular response to inorganic substance 30.0000 4 no
GO:0071248 cellular response to metal ion 30.0000 5 no
GO:0120036 plasma membrane bounded cell projection organization 30.0000 5 no
GO:1990778 protein localization to cell periphery 30.0000 5 no
GO:0010942 positive regulation of cell death 30.0000 5 no
GO:0030162 regulation of proteolysis 30.0000 6 no
GO:0051336 regulation of hydrolase activity 30.0000 4 no
GO:0060291 long-term synaptic potentiation 30.0000 4 no
GO:0097305 response to alcohol 30.0000 4 no
GO:0032386 regulation of intracellular transport 30.0000 5 no
GO:0042127 regulation of cell population proliferation 30.0000 4 no
GO:0071417 cellular response to organonitrogen compound 30.0000 4 no
GO:1901699 cellular response to nitrogen compound 30.0000 4 no
GO:1901701 cellular response to oxygen-containing compound 30.0000 4 no
GO:0009892 negative regulation of metabolic process 30.0000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 30.0000 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 30.0000 5 no
GO:0051248 negative regulation of protein metabolic process 30.0000 6 no
GO:1903076 regulation of protein localization to plasma membrane 30.0000 7 no
GO:1903078 positive regulation of protein localization to plasma membrane 30.0000 7 no
GO:1904375 regulation of protein localization to cell periphery 30.0000 6 no
GO:1904377 positive regulation of protein localization to cell periphery 30.0000 6 no
GO:0010752 regulation of cGMP-mediated signaling 20.0000 6 yes
GO:0010754 negative regulation of cGMP-mediated signaling 20.0000 7 yes
GO:0046068 cGMP metabolic process 20.0000 7 yes
GO:0046069 cGMP catabolic process 20.0000 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
AKAP5_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE1_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE2_HUMAN [view entry] [view interactions] Low throughput yes no
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
PDE10_HUMAN [view entry] [view interactions] Low throughput yes no
WDR3_HUMAN [view interactions] High throughput no no
APH1A_HUMAN [view interactions] High throughput no yes
APH1B_HUMAN [view interactions] High throughput no no
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
CASA1_HUMAN [view interactions] High throughput no no
HNRPL_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
CSK_HUMAN [view interactions] High throughput no yes
TOP1_HUMAN [view interactions] High throughput no yes
CNGA3_HUMAN [view interactions] High throughput no no
CP2U1_HUMAN [view interactions] High throughput no yes
PDE7A_HUMAN [view interactions] High throughput no yes
PDE8A_HUMAN [view entry] [view interactions] High throughput yes yes
PDE3A_HUMAN [view interactions] High throughput no no
PDE5A_HUMAN [view interactions] High throughput no yes
PDE6C_HUMAN [view interactions] High throughput no no
LAT1_HUMAN [view interactions] High throughput no yes