Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AKAP5_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Multivalent scaffold protein that anchors the cAMP-dependent protein kinase/PKA to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors (PubMed). Association with the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Plays a role in long term synaptic potentiation by regulating protein trafficking from the dendritic recycling endosomes to the plasma membrane and controlling both structural and functional plasticity at excitatory synapses (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in AKAP5_HUMAN
GO:0043168 anion binding 44.6809 4 no
GO:0019900 kinase binding 40.4255 4 no
GO:0043169 cation binding 40.4255 4 no
GO:0046872 metal ion binding 40.4255 5 no
GO:0000166 nucleotide binding 36.1702 4 no
GO:0017076 purine nucleotide binding 36.1702 5 no
GO:0032555 purine ribonucleotide binding 36.1702 4 no
GO:0019901 protein kinase binding 34.0426 5 no
GO:0035639 purine ribonucleoside triphosphate binding 27.6596 4 no
GO:0030554 adenyl nucleotide binding 23.4043 6 no
GO:0032559 adenyl ribonucleotide binding 23.4043 5 no
GO:0005509 calcium ion binding 23.4043 6 no
GO:0019902 phosphatase binding 19.1489 4 yes
GO:0019903 protein phosphatase binding 14.8936 5 yes
GO:0001664 G protein-coupled receptor binding 10.6383 4 yes
GO:0008179 adenylate cyclase binding 8.5106 4 yes
GO:0035254 glutamate receptor binding 8.5106 4 yes
GO:0031690 adrenergic receptor binding 6.3830 5 yes
GO:0017124 SH3 domain binding 4.2553 4 yes
GO:0030346 protein phosphatase 2B binding 4.2553 6 yes
GO:0031698 beta-2 adrenergic receptor binding 4.2553 6 yes
GO:0034237 protein kinase A regulatory subunit binding 4.2553 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in AKAP5_HUMAN
GO:0048522 positive regulation of cellular process 76.5957 4 yes
GO:0048523 negative regulation of cellular process 70.2128 4 no
GO:0060255 regulation of macromolecule metabolic process 68.0851 4 no
GO:0031323 regulation of cellular metabolic process 65.9574 4 no
GO:0080090 regulation of primary metabolic process 65.9574 4 no
GO:0010646 regulation of cell communication 61.7021 4 yes
GO:0009966 regulation of signal transduction 53.1915 4 yes
GO:0051049 regulation of transport 51.0638 4 yes
GO:0022607 cellular component assembly 48.9362 4 no
GO:0009893 positive regulation of metabolic process 48.9362 4 no
GO:0051246 regulation of protein metabolic process 46.8085 5 no
GO:1902531 regulation of intracellular signal transduction 44.6809 5 yes
GO:0009889 regulation of biosynthetic process 44.6809 4 no
GO:0010556 regulation of macromolecule biosynthetic process 44.6809 5 no
GO:0010604 positive regulation of macromolecule metabolic process 44.6809 5 no
GO:0031325 positive regulation of cellular metabolic process 44.6809 5 no
GO:0031326 regulation of cellular biosynthetic process 44.6809 5 no
GO:0051128 regulation of cellular component organization 44.6809 4 no
GO:0048584 positive regulation of response to stimulus 42.5532 4 yes
GO:0010468 regulation of gene expression 42.5532 6 no
GO:0008104 protein localization 42.5532 4 no
GO:0010647 positive regulation of cell communication 42.5532 5 yes
GO:0023056 positive regulation of signaling 42.5532 4 yes
GO:0009892 negative regulation of metabolic process 38.2979 4 no
GO:0031324 negative regulation of cellular metabolic process 38.2979 5 no
GO:0051050 positive regulation of transport 36.1702 4 yes
GO:0019220 regulation of phosphate metabolic process 36.1702 6 no
GO:0031399 regulation of protein modification process 36.1702 6 no
GO:0051174 regulation of phosphorus metabolic process 36.1702 5 no
GO:0009967 positive regulation of signal transduction 36.1702 5 yes
GO:0060341 regulation of cellular localization 34.0426 4 yes
GO:0001932 regulation of protein phosphorylation 34.0426 7 no
GO:0042325 regulation of phosphorylation 34.0426 7 no
GO:0010605 negative regulation of macromolecule metabolic process 31.9149 5 no
GO:0051247 positive regulation of protein metabolic process 31.9149 6 no
GO:0071310 cellular response to organic substance 31.9149 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 31.9149 5 no
GO:0141124 intracellular signaling cassette 31.9149 4 no
GO:0032880 regulation of protein localization 29.7872 5 yes
GO:0034762 regulation of transmembrane transport 29.7872 4 yes
GO:0043269 regulation of monoatomic ion transport 29.7872 5 yes
GO:0050804 modulation of chemical synaptic transmission 29.7872 5 yes
GO:0099177 regulation of trans-synaptic signaling 29.7872 4 yes
GO:0042127 regulation of cell population proliferation 29.7872 4 no
GO:0044057 regulation of system process 29.7872 4 no
GO:0051726 regulation of cell cycle 29.7872 4 no
GO:0034765 regulation of monoatomic ion transmembrane transport 27.6596 5 yes
GO:1902533 positive regulation of intracellular signal transduction 27.6596 6 yes
GO:1904062 regulation of monoatomic cation transmembrane transport 27.6596 6 yes
GO:0023057 negative regulation of signaling 27.6596 4 no
GO:0071702 organic substance transport 27.6596 4 no
GO:0071705 nitrogen compound transport 27.6596 4 no
GO:0033365 protein localization to organelle 27.6596 5 no
GO:0051252 regulation of RNA metabolic process 27.6596 5 no
GO:0010959 regulation of metal ion transport 27.6596 6 yes
GO:0001934 positive regulation of protein phosphorylation 25.5319 8 no
GO:0010243 response to organonitrogen compound 25.5319 4 no
GO:0010562 positive regulation of phosphorus metabolic process 25.5319 6 no
GO:0010648 negative regulation of cell communication 25.5319 5 no
GO:0031401 positive regulation of protein modification process 25.5319 7 no
GO:0042327 positive regulation of phosphorylation 25.5319 8 no
GO:0045937 positive regulation of phosphate metabolic process 25.5319 7 no
GO:0048585 negative regulation of response to stimulus 25.5319 4 no
GO:1901701 cellular response to oxygen-containing compound 25.5319 4 no
GO:0006355 regulation of DNA-templated transcription 25.5319 7 no
GO:0009891 positive regulation of biosynthetic process 25.5319 5 no
GO:2001141 regulation of RNA biosynthetic process 25.5319 6 no
GO:0051924 regulation of calcium ion transport 23.4043 7 yes
GO:0006996 organelle organization 23.4043 4 no
GO:0009968 negative regulation of signal transduction 23.4043 5 no
GO:0031344 regulation of cell projection organization 23.4043 5 no
GO:0043549 regulation of kinase activity 23.4043 5 no
GO:0045595 regulation of cell differentiation 23.4043 4 no
GO:0045859 regulation of protein kinase activity 23.4043 6 no
GO:0051094 positive regulation of developmental process 23.4043 4 no
GO:0051338 regulation of transferase activity 23.4043 4 no
GO:2000026 regulation of multicellular organismal development 23.4043 4 no
GO:0022603 regulation of anatomical structure morphogenesis 23.4043 4 no
GO:0043933 protein-containing complex organization 23.4043 4 no
GO:0031328 positive regulation of cellular biosynthetic process 23.4043 6 no
GO:0043270 positive regulation of monoatomic ion transport 21.2766 5 yes
GO:0060627 regulation of vesicle-mediated transport 21.2766 4 yes
GO:1903169 regulation of calcium ion transmembrane transport 21.2766 7 yes
GO:0010563 negative regulation of phosphorus metabolic process 21.2766 6 no
GO:0014070 response to organic cyclic compound 21.2766 4 no
GO:0030030 cell projection organization 21.2766 4 no
GO:0030334 regulation of cell migration 21.2766 5 no
GO:0045936 negative regulation of phosphate metabolic process 21.2766 7 no
GO:0051241 negative regulation of multicellular organismal process 21.2766 4 no
GO:0051248 negative regulation of protein metabolic process 21.2766 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 21.2766 6 no
GO:2000145 regulation of cell motility 21.2766 4 no
GO:0006357 regulation of transcription by RNA polymerase II 21.2766 8 no
GO:0010038 response to metal ion 21.2766 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 21.2766 6 no
GO:0010564 regulation of cell cycle process 21.2766 5 no
GO:1901699 cellular response to nitrogen compound 21.2766 4 no
GO:0044087 regulation of cellular component biogenesis 21.2766 4 no
GO:0034764 positive regulation of transmembrane transport 19.1489 5 yes
GO:0034767 positive regulation of monoatomic ion transmembrane transport 19.1489 6 yes
GO:1904064 positive regulation of cation transmembrane transport 19.1489 7 yes
GO:0051223 regulation of protein transport 17.0213 5 yes
GO:0051928 positive regulation of calcium ion transport 17.0213 6 yes
GO:0070201 regulation of establishment of protein localization 17.0213 6 yes
GO:0098916 anterograde trans-synaptic signaling 17.0213 6 yes
GO:0099536 synaptic signaling 17.0213 4 yes
GO:0099537 trans-synaptic signaling 17.0213 5 yes
GO:1903829 positive regulation of protein localization 17.0213 5 yes
GO:1904427 positive regulation of calcium ion transmembrane transport 17.0213 7 yes
GO:0007268 chemical synaptic transmission 17.0213 7 yes
GO:0050848 regulation of calcium-mediated signaling 14.8936 6 yes
GO:0043086 negative regulation of catalytic activity 12.7660 4 yes
GO:0050806 positive regulation of synaptic transmission 12.7660 5 yes
GO:0051222 positive regulation of protein transport 12.7660 5 yes
GO:1904951 positive regulation of establishment of protein localization 12.7660 6 yes
GO:0032386 regulation of intracellular transport 12.7660 5 yes
GO:0090279 regulation of calcium ion import 10.6383 8 yes
GO:1905475 regulation of protein localization to membrane 10.6383 6 yes
GO:0032388 positive regulation of intracellular transport 8.5106 5 yes
GO:0033157 regulation of intracellular protein transport 8.5106 6 yes
GO:0050850 positive regulation of calcium-mediated signaling 8.5106 7 yes
GO:0070884 regulation of calcineurin-NFAT signaling cascade 8.5106 8 yes
GO:0070886 positive regulation of calcineurin-NFAT signaling cascade 8.5106 9 yes
GO:0090280 positive regulation of calcium ion import 8.5106 7 yes
GO:0090316 positive regulation of intracellular protein transport 8.5106 6 yes
GO:0106056 regulation of calcineurin-mediated signaling 8.5106 7 yes
GO:0106058 positive regulation of calcineurin-mediated signaling 8.5106 8 yes
GO:1903076 regulation of protein localization to plasma membrane 8.5106 7 yes
GO:1904375 regulation of protein localization to cell periphery 8.5106 6 yes
GO:1905664 regulation of calcium ion import across plasma membrane 8.5106 8 yes
GO:1905665 positive regulation of calcium ion import across plasma membrane 8.5106 8 yes
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 8.5106 4 yes
GO:1903078 positive regulation of protein localization to plasma membrane 6.3830 7 yes
GO:1904377 positive regulation of protein localization to cell periphery 6.3830 6 yes
GO:1905477 positive regulation of protein localization to membrane 6.3830 6 yes
GO:2001135 regulation of endocytic recycling 4.2553 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KAP3_HUMAN [view entry] [view interactions] Low throughput yes yes
PP2BA_HUMAN [view entry] [view interactions] Low throughput yes yes
RXFP1_HUMAN [view interactions] Low throughput no yes
KCNK2_HUMAN [view entry] [view interactions] Low throughput yes no
AKA11_HUMAN [view interactions] Low throughput no yes
PP2BB_HUMAN [view entry] [view interactions] Low throughput yes yes
CANB1_HUMAN [view entry] [view interactions] Low throughput yes yes
GBRB3_HUMAN [view entry] [view interactions] Low throughput yes no
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE2_HUMAN [view entry] [view interactions] Low throughput yes no
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIA1_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
TRPV1_HUMAN [view entry] [view interactions] Low throughput yes no
PDE10_HUMAN [view entry] [view interactions] Low throughput yes no
IQGA1_HUMAN [view entry] [view interactions] Low throughput yes no
CALM2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
CAD22_HUMAN [view interactions] Low throughput no no
CADH1_HUMAN [view entry] [view interactions] Low throughput yes no
CADH2_HUMAN [view entry] [view interactions] Low throughput yes no
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
KCNJ2_HUMAN [view entry] [view interactions] Low throughput yes yes
ADCY2_HUMAN [view interactions] Low throughput no yes
KAP2_HUMAN [view entry] [view interactions] Low throughput yes yes
KAPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
CLK1_HUMAN [view interactions] High throughput no yes
KAPCB_HUMAN [view entry] [view interactions] High throughput yes yes
NUCL_HUMAN [view interactions] High throughput no yes
S2512_HUMAN [view entry] [view interactions] High throughput yes yes
HSP72_HUMAN [view entry] [view interactions] High throughput yes no
OTU6B_HUMAN [view interactions] High throughput no yes
KAPCG_HUMAN [view interactions] High throughput no no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CDK1_HUMAN [view interactions] High throughput no no
KAP0_HUMAN [view entry] [view interactions] High throughput yes yes
ROP1A_HUMAN [view interactions] High throughput no no
ROP1L_HUMAN [view interactions] High throughput no no
TMM17_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
CTDSL_HUMAN [view interactions] High throughput no no
JUN_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
FOS_HUMAN [view interactions] High throughput no yes
MDM2_HUMAN [view entry] [view interactions] High throughput yes yes
NMDZ1_HUMAN [view entry] [view interactions] High throughput yes yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
TNPO1_HUMAN [view entry] [view interactions] High throughput yes yes
DERL1_HUMAN [view interactions] High throughput no yes
RM43_HUMAN [view interactions] High throughput no no
TRPV4_HUMAN [view interactions] High throughput no yes
TRPM8_HUMAN [view interactions] High throughput no no
TRPA1_HUMAN [view interactions] High throughput no no
TRPV2_HUMAN [view interactions] High throughput no yes
TRPV3_HUMAN [view interactions] High throughput no no
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
E41L3_HUMAN [view entry] [view interactions] High throughput yes yes
PTPRA_HUMAN [view interactions] High throughput no yes
CK052_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
OCLN_HUMAN [view interactions] High throughput no no
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
ZFPL1_HUMAN [view interactions] High throughput no yes
NRP1_HUMAN [view entry] [view interactions] High throughput yes yes
AMPN_HUMAN [view interactions] High throughput no no
H31_HUMAN [view interactions] High throughput no yes
RSBNL_HUMAN [view interactions] High throughput no yes
RMXL1_HUMAN [view interactions] High throughput no yes
PRP4B_HUMAN [view interactions] High throughput no yes
IPO4_HUMAN [view interactions] High throughput no no
SMS2_HUMAN [view interactions] High throughput no yes
SUV91_HUMAN [view interactions] High throughput no no
LC7L3_HUMAN [view interactions] High throughput no yes