Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AKAP5_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Multivalent scaffold protein that anchors the cAMP-dependent protein kinase/PKA to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors (PubMed). Association with the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Plays a role in long term synaptic potentiation by regulating protein trafficking from the dendritic recycling endosomes to the plasma membrane and controlling both structural and functional plasticity at excitatory synapses (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in AKAP5_HUMAN
GO:0017076 purine nucleotide binding 37.0968 4 no
GO:0032555 purine ribonucleotide binding 37.0968 4 no
GO:0046872 metal ion binding 33.8710 4 no
GO:0019900 kinase binding 30.6452 4 no
GO:0019901 protein kinase binding 29.0323 5 no
GO:0030554 adenyl nucleotide binding 27.4194 5 no
GO:0032559 adenyl ribonucleotide binding 27.4194 5 no
GO:0035639 purine ribonucleoside triphosphate binding 27.4194 4 no
GO:0005216 ion channel activity 20.9677 4 no
GO:0015267 channel activity 20.9677 4 no
GO:0022836 gated channel activity 20.9677 5 no
GO:0019902 phosphatase binding 16.1290 4 yes
GO:0019903 protein phosphatase binding 12.9032 5 yes
GO:0035254 glutamate receptor binding 11.2903 4 yes
GO:0008179 adenylate cyclase binding 9.6774 4 yes
GO:0001664 G protein-coupled receptor binding 8.0645 4 yes
GO:0034237 protein kinase A regulatory subunit binding 4.8387 4 yes
GO:0017124 SH3 domain binding 3.2258 4 yes
GO:0030346 protein phosphatase 2B binding 3.2258 6 yes
GO:0031690 adrenergic receptor binding 3.2258 5 yes
GO:0031698 beta-2 adrenergic receptor binding 3.2258 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in AKAP5_HUMAN
GO:0048522 positive regulation of cellular process 69.3548 4 yes
GO:0048523 negative regulation of cellular process 58.0645 4 no
GO:0010646 regulation of cell communication 58.0645 4 yes
GO:0051049 regulation of transport 58.0645 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 56.4516 4 no
GO:0060255 regulation of macromolecule metabolic process 56.4516 4 no
GO:0080090 regulation of primary metabolic process 56.4516 4 no
GO:0031323 regulation of cellular metabolic process 53.2258 4 no
GO:0009893 positive regulation of metabolic process 43.5484 4 no
GO:0051246 regulation of protein metabolic process 43.5484 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 41.9355 5 no
GO:0009966 regulation of signal transduction 41.9355 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 40.3226 5 no
GO:0031325 positive regulation of cellular metabolic process 40.3226 5 no
GO:0008104 protein localization 38.7097 4 no
GO:0051128 regulation of cellular component organization 38.7097 4 no
GO:0050804 modulation of chemical synaptic transmission 38.7097 5 yes
GO:0099177 regulation of trans-synaptic signaling 38.7097 4 yes
GO:0010468 regulation of gene expression 37.0968 5 no
GO:0022607 cellular component assembly 37.0968 4 no
GO:0031399 regulation of protein modification process 35.4839 6 no
GO:0019220 regulation of phosphate metabolic process 33.8710 6 no
GO:0051174 regulation of phosphorus metabolic process 33.8710 5 no
GO:0010647 positive regulation of cell communication 33.8710 5 yes
GO:0023056 positive regulation of signaling 33.8710 4 yes
GO:0043269 regulation of ion transport 32.2581 5 no
GO:0001932 regulation of protein phosphorylation 32.2581 7 no
GO:0042325 regulation of phosphorylation 32.2581 7 no
GO:0051050 positive regulation of transport 32.2581 4 yes
GO:0009889 regulation of biosynthetic process 29.0323 4 no
GO:0009892 negative regulation of metabolic process 29.0323 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 29.0323 5 no
GO:0031324 negative regulation of cellular metabolic process 29.0323 5 no
GO:0044057 regulation of system process 29.0323 4 no
GO:0071310 cellular response to organic substance 29.0323 4 no
GO:0051247 positive regulation of protein metabolic process 29.0323 6 no
GO:0060341 regulation of cellular localization 29.0323 4 yes
GO:1902531 regulation of intracellular signal transduction 27.4194 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 27.4194 5 no
GO:0031326 regulation of cellular biosynthetic process 27.4194 5 no
GO:0051252 regulation of RNA metabolic process 27.4194 5 no
GO:0071702 organic substance transport 27.4194 4 no
GO:0071705 nitrogen compound transport 27.4194 4 no
GO:0034762 regulation of transmembrane transport 27.4194 4 no
GO:0034765 regulation of ion transmembrane transport 27.4194 5 no
GO:1904062 regulation of cation transmembrane transport 27.4194 6 no
GO:0006355 regulation of DNA-templated transcription 25.8065 6 no
GO:1903506 regulation of nucleic acid-templated transcription 25.8065 7 no
GO:2001141 regulation of RNA biosynthetic process 25.8065 6 no
GO:0016192 vesicle-mediated transport 25.8065 4 no
GO:0010562 positive regulation of phosphorus metabolic process 25.8065 6 no
GO:0031401 positive regulation of protein modification process 25.8065 7 no
GO:0045937 positive regulation of phosphate metabolic process 25.8065 7 no
GO:0051338 regulation of transferase activity 25.8065 4 no
GO:0032880 regulation of protein localization 25.8065 5 yes
GO:0043085 positive regulation of catalytic activity 25.8065 4 yes
GO:0010243 response to organonitrogen compound 24.1935 4 no
GO:0010605 negative regulation of macromolecule metabolic process 24.1935 5 no
GO:0033365 protein localization to organelle 24.1935 5 no
GO:0048584 positive regulation of response to stimulus 24.1935 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 24.1935 5 no
GO:0051240 positive regulation of multicellular organismal process 24.1935 4 no
GO:0010959 regulation of metal ion transport 24.1935 6 no
GO:0001934 positive regulation of protein phosphorylation 24.1935 8 no
GO:0042327 positive regulation of phosphorylation 24.1935 8 no
GO:0043549 regulation of kinase activity 24.1935 5 no
GO:0045859 regulation of protein kinase activity 24.1935 6 no
GO:0006796 phosphate-containing compound metabolic process 22.5806 4 no
GO:0014070 response to organic cyclic compound 22.5806 4 no
GO:0051726 regulation of cell cycle 22.5806 4 no
GO:0015031 protein transport 20.9677 4 no
GO:0022603 regulation of anatomical structure morphogenesis 20.9677 4 no
GO:0090257 regulation of muscle system process 20.9677 5 no
GO:0009967 positive regulation of signal transduction 20.9677 5 no
GO:0006996 organelle organization 20.9677 4 no
GO:0010941 regulation of cell death 20.9677 4 no
GO:0022898 regulation of transmembrane transporter activity 20.9677 4 no
GO:0032412 regulation of ion transmembrane transporter activity 20.9677 5 no
GO:0060627 regulation of vesicle-mediated transport 17.7419 4 yes
GO:1903829 positive regulation of protein localization 14.5161 5 yes
GO:0050806 positive regulation of synaptic transmission 14.5161 5 yes
GO:0051223 regulation of protein transport 14.5161 5 yes
GO:0070201 regulation of establishment of protein localization 14.5161 6 yes
GO:0007268 chemical synaptic transmission 12.9032 6 yes
GO:0043086 negative regulation of catalytic activity 12.9032 4 yes
GO:0098916 anterograde trans-synaptic signaling 12.9032 5 yes
GO:0099537 trans-synaptic signaling 12.9032 4 yes
GO:1905475 regulation of protein localization to membrane 11.2903 6 yes
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 9.6774 4 yes
GO:1904375 regulation of protein localization to cell periphery 8.0645 6 yes
GO:1904951 positive regulation of establishment of protein localization 8.0645 6 yes
GO:1905477 positive regulation of protein localization to membrane 8.0645 6 yes
GO:0051222 positive regulation of protein transport 8.0645 5 yes
GO:1903076 regulation of protein localization to plasma membrane 6.4516 7 yes
GO:1904377 positive regulation of protein localization to cell periphery 6.4516 6 yes
GO:0031279 regulation of cyclase activity 6.4516 4 yes
GO:0031281 positive regulation of cyclase activity 6.4516 5 yes
GO:0032386 regulation of intracellular transport 6.4516 5 yes
GO:0033157 regulation of intracellular protein transport 6.4516 6 yes
GO:0045761 regulation of adenylate cyclase activity 6.4516 5 yes
GO:0045762 positive regulation of adenylate cyclase activity 6.4516 6 yes
GO:0051339 regulation of lyase activity 6.4516 4 yes
GO:0051349 positive regulation of lyase activity 6.4516 5 yes
GO:1903078 positive regulation of protein localization to plasma membrane 4.8387 7 yes
GO:0010738 regulation of protein kinase A signaling 4.8387 6 yes
GO:0032388 positive regulation of intracellular transport 4.8387 5 yes
GO:0090316 positive regulation of intracellular protein transport 4.8387 6 yes
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 3.2258 5 yes
GO:1900271 regulation of long-term synaptic potentiation 3.2258 4 yes
GO:1900273 positive regulation of long-term synaptic potentiation 3.2258 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in AKAP5_HUMAN
DOID:0050700 cardiomyopathy 4.8387 4 no
DOID:0060036 intrinsic cardiomyopathy 4.8387 5 no
DOID:114 heart disease 4.8387 3 no
DOID:2843 long QT syndrome 4.8387 6 no
DOID:10273 heart conduction disease 3.2258 4 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KCNJ2_HUMAN [view entry] [view interactions] Low throughput yes yes
ADCY2_HUMAN [view interactions] Low throughput no yes
KAPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
KAP2_HUMAN [view entry] [view interactions] Low throughput yes yes
KAP3_HUMAN [view entry] [view interactions] Low throughput yes yes
PP2BA_HUMAN [view entry] [view interactions] Low throughput yes yes
RXFP1_HUMAN [view interactions] Low throughput no yes
KCNK2_HUMAN [view interactions] Low throughput no no
AKA11_HUMAN [view interactions] Low throughput no yes
PP2BB_HUMAN [view entry] [view interactions] Low throughput yes yes
CANB1_HUMAN [view entry] [view interactions] Low throughput yes yes
GBRB3_HUMAN [view entry] [view interactions] Low throughput yes no
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE2_HUMAN [view entry] [view interactions] Low throughput yes no
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIA1_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
TRPV1_HUMAN [view entry] [view interactions] Low throughput yes no
PDE10_HUMAN [view entry] [view interactions] Low throughput yes no
IQGA1_HUMAN [view entry] [view interactions] Low throughput yes no
CALM2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
CAD22_HUMAN [view interactions] Low throughput no no
CADH1_HUMAN [view entry] [view interactions] Low throughput yes no
CADH2_HUMAN [view entry] [view interactions] Low throughput yes no
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
OTU6B_HUMAN [view interactions] High throughput no yes
HSP72_HUMAN [view entry] [view interactions] High throughput yes no
CMC1_HUMAN [view entry] [view interactions] High throughput yes yes
NUCL_HUMAN [view interactions] High throughput no yes
KAPCB_HUMAN [view entry] [view interactions] High throughput yes yes
CLK1_HUMAN [view interactions] High throughput no yes
LC7L3_HUMAN [view interactions] High throughput no yes
SUV91_HUMAN [view interactions] High throughput no no
SMS2_HUMAN [view interactions] High throughput no yes
IPO4_HUMAN [view interactions] High throughput no no
PRP4B_HUMAN [view interactions] High throughput no yes
RMXL1_HUMAN [view interactions] High throughput no yes
RSBNL_HUMAN [view interactions] High throughput no yes
H31_HUMAN [view interactions] High throughput no yes
KAPCG_HUMAN [view interactions] High throughput no no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CDK1_HUMAN [view interactions] High throughput no no
KAP0_HUMAN [view entry] [view interactions] High throughput yes yes
ROP1A_HUMAN [view interactions] High throughput no no
ROP1L_HUMAN [view interactions] High throughput no no
TMM17_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
CTDSL_HUMAN [view interactions] High throughput no no
JUN_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
FOS_HUMAN [view interactions] High throughput no yes
MDM2_HUMAN [view interactions] High throughput no yes
NMDZ1_HUMAN [view entry] [view interactions] High throughput yes yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
TNPO1_HUMAN [view entry] [view interactions] High throughput yes yes
DERL1_HUMAN [view interactions] High throughput no yes
RM43_HUMAN [view interactions] High throughput no no
TRPV4_HUMAN [view interactions] High throughput no yes
TRPM8_HUMAN [view interactions] High throughput no no
TRPA1_HUMAN [view interactions] High throughput no no
TRPV2_HUMAN [view interactions] High throughput no yes
TRPV3_HUMAN [view interactions] High throughput no no
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
E41L3_HUMAN [view entry] [view interactions] High throughput yes yes
PTPRA_HUMAN [view interactions] High throughput no yes
CK052_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP1_HUMAN [view interactions] High throughput no yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
OCLN_HUMAN [view interactions] High throughput no no
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
ZFPL1_HUMAN [view interactions] High throughput no yes
NRP1_HUMAN [view entry] [view interactions] High throughput yes yes
AMPN_HUMAN [view interactions] High throughput no no
AKAP1_HUMAN [view entry] [view interactions] Computational yes yes
KCC2B_HUMAN [view entry] [view interactions] Computational yes yes
ADCY8_HUMAN [view entry] [view interactions] Computational yes yes
AKP13_HUMAN [view interactions] Computational no yes
KAP1_HUMAN [view entry] [view interactions] Computational yes yes
ADCY5_HUMAN [view interactions] Computational no no
ROBO3_HUMAN [view interactions] Computational no no
CCG4_HUMAN [view entry] [view interactions] Computational yes no
MYO6_HUMAN [view entry] [view interactions] Computational yes no
ADRB2_HUMAN [view entry] [view interactions] Computational yes no
E41L1_HUMAN [view entry] [view interactions] Computational yes yes
GRIA3_HUMAN [view entry] [view interactions] Computational yes yes
CCG2_HUMAN [view entry] [view interactions] Computational yes no
ADCY6_HUMAN [view interactions] Computational no yes
CABP1_HUMAN [view entry] [view interactions] Computational yes yes
CCG8_HUMAN [view entry] [view interactions] Computational yes no
RPGF4_HUMAN [view entry] [view interactions] Computational yes yes
AKA12_HUMAN [view entry] [view interactions] Computational yes no
GRIA4_HUMAN [view entry] [view interactions] Computational yes no
AKA7G_HUMAN [view interactions] Computational no yes
RPGF3_HUMAN [view interactions] Computational no yes
KCC2D_HUMAN [view entry] [view interactions] Computational yes yes
ROBO2_HUMAN [view interactions] Computational no yes
CAC1C_HUMAN [view entry] [view interactions] Computational yes no
CCG3_HUMAN [view entry] [view interactions] Computational yes no