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KAP3_HUMAN

Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in KAP3_HUMAN
GO:0017076 purine nucleotide binding 34.6154 4 yes
GO:0032555 purine ribonucleotide binding 34.6154 4 yes
GO:0046872 metal ion binding 33.3333 4 no
GO:0019900 kinase binding 28.2051 4 yes
GO:0019901 protein kinase binding 26.9231 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 26.9231 4 no
GO:0030554 adenyl nucleotide binding 25.6410 5 yes
GO:0032559 adenyl ribonucleotide binding 25.6410 5 yes
GO:0019887 protein kinase regulator activity 12.8205 4 yes
GO:0031625 ubiquitin protein ligase binding 11.5385 5 yes
GO:0044389 ubiquitin-like protein ligase binding 11.5385 4 yes
GO:0034236 protein kinase A catalytic subunit binding 8.9744 4 yes
GO:0004860 protein kinase inhibitor activity 7.6923 5 yes
GO:0004862 cAMP-dependent protein kinase inhibitor activity 7.6923 6 yes
GO:0008603 cAMP-dependent protein kinase regulator activity 7.6923 5 yes
GO:0019210 kinase inhibitor activity 7.6923 4 yes
GO:0030291 protein serine/threonine kinase inhibitor activity 7.6923 6 yes
GO:0030551 cyclic nucleotide binding 7.6923 4 yes
GO:0030552 cAMP binding 7.6923 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in KAP3_HUMAN
GO:0048522 positive regulation of cellular process 58.9744 4 no
GO:0010646 regulation of cell communication 56.4103 4 yes
GO:0060255 regulation of macromolecule metabolic process 53.8462 4 yes
GO:0080090 regulation of primary metabolic process 53.8462 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 52.5641 4 yes
GO:0031323 regulation of cellular metabolic process 52.5641 4 yes
GO:0048523 negative regulation of cellular process 50.0000 4 yes
GO:0051246 regulation of protein metabolic process 50.0000 5 yes
GO:0009966 regulation of signal transduction 46.1538 4 no
GO:0051174 regulation of phosphorus metabolic process 42.3077 5 yes
GO:0019220 regulation of phosphate metabolic process 42.3077 6 yes
GO:0009893 positive regulation of metabolic process 41.0256 4 no
GO:0051049 regulation of transport 37.1795 4 no
GO:0031399 regulation of protein modification process 37.1795 6 yes
GO:0042325 regulation of phosphorylation 37.1795 7 yes
GO:0006996 organelle organization 34.6154 4 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0022607 cellular component assembly 33.3333 4 no
GO:0031325 positive regulation of cellular metabolic process 32.0513 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 32.0513 5 no
GO:0051247 positive regulation of protein metabolic process 32.0513 6 no
GO:0001932 regulation of protein phosphorylation 32.0513 7 yes
GO:0051128 regulation of cellular component organization 30.7692 4 no
GO:0010647 positive regulation of cell communication 29.4872 5 no
GO:0023056 positive regulation of signaling 29.4872 4 no
GO:1902531 regulation of intracellular signal transduction 29.4872 5 no
GO:0043085 positive regulation of catalytic activity 29.4872 4 no
GO:0010243 response to organonitrogen compound 29.4872 4 yes
GO:0008104 protein localization 28.2051 4 no
GO:0051050 positive regulation of transport 28.2051 4 no
GO:0009892 negative regulation of metabolic process 28.2051 4 yes
GO:0010468 regulation of gene expression 26.9231 5 no
GO:0006796 phosphate-containing compound metabolic process 26.9231 4 no
GO:0036211 protein modification process 26.9231 4 no
GO:0043412 macromolecule modification 26.9231 4 no
GO:0050804 modulation of chemical synaptic transmission 25.6410 5 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 25.6410 5 yes
GO:0051338 regulation of transferase activity 25.6410 4 yes
GO:0099177 regulation of trans-synaptic signaling 25.6410 4 yes
GO:0071310 cellular response to organic substance 25.6410 4 no
GO:0010941 regulation of cell death 25.6410 4 no
GO:0031324 negative regulation of cellular metabolic process 25.6410 5 yes
GO:0030030 cell projection organization 24.3590 4 no
GO:0060341 regulation of cellular localization 24.3590 4 no
GO:0010562 positive regulation of phosphorus metabolic process 24.3590 6 no
GO:0045937 positive regulation of phosphate metabolic process 24.3590 7 no
GO:0043067 regulation of programmed cell death 24.3590 5 no
GO:0048584 positive regulation of response to stimulus 24.3590 4 no
GO:0010605 negative regulation of macromolecule metabolic process 24.3590 5 yes
GO:0043933 protein-containing complex organization 23.0769 4 no
GO:0031401 positive regulation of protein modification process 23.0769 7 no
GO:0042327 positive regulation of phosphorylation 23.0769 8 no
GO:0042981 regulation of apoptotic process 23.0769 6 no
GO:0014070 response to organic cyclic compound 23.0769 4 yes
GO:0043549 regulation of kinase activity 23.0769 5 yes
GO:0051248 negative regulation of protein metabolic process 21.7949 6 yes
GO:0120036 plasma membrane bounded cell projection organization 21.7949 5 no
GO:0009967 positive regulation of signal transduction 21.7949 5 no
GO:0043269 regulation of ion transport 20.5128 5 no
GO:0001934 positive regulation of protein phosphorylation 20.5128 8 no
GO:0051336 regulation of hydrolase activity 20.5128 4 no
GO:1901701 cellular response to oxygen-containing compound 20.5128 4 no
GO:0010563 negative regulation of phosphorus metabolic process 20.5128 6 yes
GO:0031400 negative regulation of protein modification process 20.5128 7 yes
GO:0045859 regulation of protein kinase activity 20.5128 6 yes
GO:0045936 negative regulation of phosphate metabolic process 20.5128 7 yes
GO:0050890 cognition 16.6667 4 yes
GO:0043086 negative regulation of catalytic activity 16.6667 4 yes
GO:0042326 negative regulation of phosphorylation 15.3846 8 yes
GO:0001933 negative regulation of protein phosphorylation 14.1026 8 yes
GO:0071900 regulation of protein serine/threonine kinase activity 12.8205 7 yes
GO:0007612 learning 8.9744 4 yes
GO:0051348 negative regulation of transferase activity 7.6923 5 yes
GO:2000479 regulation of cAMP-dependent protein kinase activity 7.6923 8 yes
GO:0006469 negative regulation of protein kinase activity 7.6923 7 yes
GO:0033673 negative regulation of kinase activity 7.6923 6 yes
GO:0071901 negative regulation of protein serine/threonine kinase activity 6.4103 8 yes
GO:2000480 negative regulation of cAMP-dependent protein kinase activity 6.4103 9 yes
GO:0097338 response to clozapine 3.8462 5 yes
GO:0019752 carboxylic acid metabolic process 3.8462 5 yes
GO:0043436 oxoacid metabolic process 3.8462 4 yes
GO:0006631 fatty acid metabolic process 2.5641 4 yes
GO:0032787 monocarboxylic acid metabolic process 2.5641 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in KAP3_HUMAN
DOID:0050700 cardiomyopathy 5.1282 4 no
DOID:0060036 intrinsic cardiomyopathy 5.1282 5 no
DOID:114 heart disease 5.1282 3 no
DOID:2843 long QT syndrome 3.8462 6 no
DOID:0060674 catecholaminergic polymorphic ventricular tachycardia 2.5641 5 no
DOID:10273 heart conduction disease 2.5641 4 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
LRRK2_HUMAN [view interactions] Low throughput no yes
KAPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
AKA11_HUMAN [view interactions] Low throughput no yes
AKAP5_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAO_HUMAN [view entry] [view interactions] Low throughput yes yes
TNR1A_HUMAN [view interactions] Low throughput no yes
GNAI3_HUMAN [view entry] [view interactions] Low throughput yes yes
CFA91_HUMAN [view interactions] Low throughput no no
RYR2_HUMAN [view entry] [view interactions] Low throughput yes yes
KAP3_HUMAN [view entry] [view interactions] Low throughput yes yes
BIG2_HUMAN [view entry] [view interactions] Low throughput yes yes
KAPCB_HUMAN [view entry] [view interactions] High throughput yes yes
MYOME_HUMAN [view interactions] High throughput no no
KAP2_HUMAN [view entry] [view interactions] High throughput yes yes
CK5P2_HUMAN [view interactions] High throughput no yes
CCD77_HUMAN [view interactions] High throughput no yes
CE170_HUMAN [view interactions] High throughput no yes
VAV2_HUMAN [view entry] [view interactions] High throughput yes yes
SURF4_HUMAN [view interactions] High throughput no yes
CEP68_HUMAN [view interactions] High throughput no yes
CSN7A_HUMAN [view interactions] High throughput no yes
PCM1_HUMAN [view interactions] High throughput no yes
CEP72_HUMAN [view interactions] High throughput no yes
SC16A_HUMAN [view interactions] High throughput no yes
BABA1_HUMAN [view interactions] High throughput no yes
OFD1_HUMAN [view interactions] High throughput no yes
MIB1_HUMAN [view entry] [view interactions] High throughput yes yes
KC1E_HUMAN [view entry] [view interactions] High throughput yes yes
NUFP1_HUMAN [view interactions] High throughput no yes
CXB7_HUMAN [view interactions] High throughput no no
ZN707_HUMAN [view interactions] High throughput no yes
AKA28_HUMAN [view interactions] High throughput no no
SP17_HUMAN [view interactions] High throughput no no
KAP0_HUMAN [view entry] [view interactions] High throughput yes yes
AKA7G_HUMAN [view interactions] High throughput no yes
ZG16B_HUMAN [view interactions] High throughput no no
CRBG3_HUMAN [view interactions] High throughput no no
PRKX_HUMAN [view interactions] High throughput no yes
KAP1_HUMAN [view entry] [view interactions] High throughput yes yes
AMY1B_HUMAN [view interactions] High throughput no no
AMY1A_HUMAN [view interactions] High throughput no no
AMY1C_HUMAN [view interactions] High throughput no no
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
KAPCG_HUMAN [view interactions] High throughput no no
ROP1A_HUMAN [view interactions] High throughput no no
SSX2_HUMAN [view interactions] High throughput no no
ALX3_HUMAN [view interactions] High throughput no no
SOX2_HUMAN [view interactions] High throughput no yes
NMDZ1_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC1_HUMAN [view interactions] High throughput no no
ARGL1_HUMAN [view interactions] High throughput no yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
TX101_HUMAN [view interactions] High throughput no no
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
KINH_HUMAN [view entry] [view interactions] High throughput yes no
ECM1_HUMAN [view interactions] High throughput no no
TAF12_HUMAN [view interactions] High throughput no yes
SMAKA_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes
TOM20_HUMAN [view entry] [view interactions] High throughput yes yes
TOM22_HUMAN [view interactions] High throughput no yes
AKA10_HUMAN [view interactions] High throughput no no
PK1IP_HUMAN [view interactions] High throughput no yes
NMDE2_HUMAN [view entry] [view interactions] High throughput yes no
USO1_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
GCH1_HUMAN [view interactions] High throughput no no
AKAP9_HUMAN [view entry] [view interactions] High throughput yes yes
AKP13_HUMAN [view interactions] High throughput no yes
AKAP2_HUMAN [view interactions] High throughput no no
MTAP2_HUMAN [view entry] [view interactions] High throughput yes yes
NAA25_HUMAN [view interactions] High throughput no yes
VAPB_HUMAN [view entry] [view interactions] High throughput yes yes
KC1D_HUMAN [view entry] [view interactions] High throughput yes yes
DC1I2_HUMAN [view entry] [view interactions] High throughput yes yes
CP131_HUMAN [view interactions] High throughput no no
HBP1_HUMAN [view interactions] High throughput no yes
HERC2_HUMAN [view interactions] High throughput no yes
IQCN_HUMAN [view interactions] High throughput no no
HAX1_HUMAN [view interactions] High throughput no no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
TRI25_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
NR2C2_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
TIP_HUMAN [view entry] [view interactions] High throughput yes yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
HPT_HUMAN [view interactions] High throughput no no
TRFE_HUMAN [view interactions] High throughput no no
H12_HUMAN [view interactions] High throughput no yes
FIBG_HUMAN [view entry] [view interactions] High throughput yes no
PTN22_HUMAN [view interactions] High throughput no yes
CEP57_HUMAN [view interactions] High throughput no yes
TOX2_HUMAN [view interactions] High throughput no no
DYL1_HUMAN [view entry] [view interactions] High throughput yes no
SCML1_HUMAN [view interactions] High throughput no no
FGOP2_HUMAN [view interactions] High throughput no yes
RN145_HUMAN [view interactions] High throughput no yes
COQ3_HUMAN [view interactions] High throughput no no
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
CCD71_HUMAN [view interactions] High throughput no no
DUS16_HUMAN [view interactions] High throughput no yes
DYL2_HUMAN [view entry] [view interactions] High throughput yes no
K0895_HUMAN [view interactions] High throughput no no
CTCFL_HUMAN [view interactions] High throughput no no
UBE3C_HUMAN [view entry] [view interactions] High throughput yes yes
ZHX1R_HUMAN [view interactions] High throughput no yes
PIGF_HUMAN [view interactions] High throughput no no
TT30B_HUMAN [view interactions] High throughput no no
MD2BP_HUMAN [view interactions] High throughput no no
LRC49_HUMAN [view interactions] High throughput no no
KIFA3_HUMAN [view entry] [view interactions] High throughput yes yes
UBXN6_HUMAN [view entry] [view interactions] High throughput yes yes
CARD9_HUMAN [view interactions] High throughput no no
OGT1_HUMAN [view entry] [view interactions] High throughput yes yes
MYCBP_HUMAN [view interactions] High throughput no yes
GNAI2_HUMAN [view entry] [view interactions] High throughput yes yes
DCAF7_HUMAN [view interactions] High throughput no yes
DYR1A_HUMAN [view interactions] High throughput no yes
LASP1_HUMAN [view entry] [view interactions] High throughput yes yes
EXD2_HUMAN [view interactions] High throughput no yes
FIS1_HUMAN [view entry] [view interactions] High throughput yes yes
FKBP8_HUMAN [view entry] [view interactions] High throughput yes yes
MAVS_HUMAN [view interactions] High throughput no yes
MFN2_HUMAN [view entry] [view interactions] High throughput yes yes
MTCH1_HUMAN [view entry] [view interactions] High throughput yes yes
MTCH2_HUMAN [view entry] [view interactions] High throughput yes yes
OCAD1_HUMAN [view interactions] High throughput no yes
PTN1_HUMAN [view interactions] High throughput no yes
MIRO2_HUMAN [view entry] [view interactions] High throughput yes yes
RMD3_HUMAN [view interactions] High throughput no yes
S2546_HUMAN [view entry] [view interactions] High throughput yes yes
PEX14_HUMAN [view interactions] High throughput no yes
NBEA_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
CCL11_HUMAN [view interactions] Computational no no
AKAP8_HUMAN [view interactions] Computational no yes
ADCY3_HUMAN [view interactions] Computational no yes
PP1A_HUMAN [view entry] [view interactions] Computational yes yes
STMN1_HUMAN [view interactions] Computational no yes
EZRI_HUMAN [view entry] [view interactions] Computational yes no
BAD_HUMAN [view entry] [view interactions] Computational yes yes
CD3Z_HUMAN [view interactions] Computational no no
CREM_HUMAN [view interactions] Computational no no
THRB_HUMAN [view interactions] Computational no no
ADCY4_HUMAN [view interactions] Computational no yes
MK03_HUMAN [view entry] [view interactions] Computational yes yes
GBB1_HUMAN [view entry] [view interactions] Computational yes yes
MPIP3_HUMAN [view interactions] Computational no yes
NOS1_HUMAN [view entry] [view interactions] Computational yes yes
FAK1_HUMAN [view entry] [view interactions] Computational yes yes
ADCY1_HUMAN [view entry] [view interactions] Computational yes no
GBG1_HUMAN [view interactions] Computational no no
2A5D_HUMAN [view entry] [view interactions] Computational yes yes
NPY4R_HUMAN [view interactions] Computational no yes
PPR1B_HUMAN [view entry] [view interactions] Computational yes yes
TLN1_HUMAN [view entry] [view interactions] Computational yes no
CREB1_HUMAN [view interactions] Computational no yes
AKAP3_HUMAN [view interactions] Computational no no
CND1_HUMAN [view interactions] Computational no yes
ADCY8_HUMAN [view entry] [view interactions] Computational yes yes
PKN1_HUMAN [view entry] [view interactions] Computational yes yes
MLC1_HUMAN [view interactions] Computational no no
BCL2_HUMAN [view interactions] Computational no no
NHRF1_HUMAN [view interactions] Computational no no
CDK1_HUMAN [view interactions] Computational no no
ADRB2_HUMAN [view entry] [view interactions] Computational yes no
ANGT_HUMAN [view interactions] Computational no no
ADCY6_HUMAN [view interactions] Computational no yes
ADCY7_HUMAN [view interactions] Computational no yes
CD2_HUMAN [view interactions] Computational no no
SDF1_HUMAN [view interactions] Computational no no
RHOA_HUMAN [view entry] [view interactions] Computational yes yes
ITA1_HUMAN [view interactions] Computational no yes
GNAS1_HUMAN [view entry] [view interactions] Computational yes yes
CSK_HUMAN [view interactions] Computational no yes
PAXI_HUMAN [view interactions] Computational no yes
MLXPL_HUMAN [view interactions] Computational no no
CCL4_HUMAN [view interactions] Computational no no
ITB1_HUMAN [view entry] [view interactions] Computational yes no
ADCY5_HUMAN [view interactions] Computational no no
CFTR_HUMAN [view interactions] Computational no no
KPCE_HUMAN [view entry] [view interactions] Computational yes yes
B2CL1_HUMAN [view interactions] Computational no yes
ADCY9_HUMAN [view interactions] Computational no yes
CCNB1_HUMAN [view interactions] Computational no no
RPGF4_HUMAN [view entry] [view interactions] Computational yes yes
EDN1_HUMAN [view interactions] Computational no no
AAKG1_HUMAN [view interactions] Computational no no
LIPS_HUMAN [view entry] [view interactions] Computational yes no