KAP3_HUMAN
Evidence for PS localization
Functions
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KAP3_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 37.3134 | 4 | yes |
| GO:0043169 | cation binding | 34.3284 | 4 | no |
| GO:0046872 | metal ion binding | 34.3284 | 5 | no |
| GO:0000166 | nucleotide binding | 31.3433 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 31.3433 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 31.3433 | 4 | yes |
| GO:0019900 | kinase binding | 26.8657 | 4 | yes |
| GO:0019901 | protein kinase binding | 23.8806 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 23.8806 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 23.8806 | 5 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 22.3881 | 4 | no |
| GO:0019887 | protein kinase regulator activity | 14.9254 | 4 | yes |
| GO:0031625 | ubiquitin protein ligase binding | 13.4328 | 5 | yes |
| GO:0044389 | ubiquitin-like protein ligase binding | 13.4328 | 4 | yes |
| GO:0004860 | protein kinase inhibitor activity | 8.9552 | 5 | yes |
| GO:0019210 | kinase inhibitor activity | 8.9552 | 4 | yes |
| GO:0030551 | cyclic nucleotide binding | 8.9552 | 5 | yes |
| GO:0030552 | cAMP binding | 8.9552 | 5 | yes |
| GO:0034236 | protein kinase A catalytic subunit binding | 8.9552 | 4 | yes |
| GO:0004862 | cAMP-dependent protein kinase inhibitor activity | 7.4627 | 6 | yes |
| GO:0008603 | cAMP-dependent protein kinase regulator activity | 7.4627 | 5 | yes |
| GO:0030291 | protein serine/threonine kinase inhibitor activity | 7.4627 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KAP3_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 64.1791 | 4 | no |
| GO:0010646 | regulation of cell communication | 56.7164 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 53.7313 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 50.7463 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 49.2537 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 47.7612 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 47.7612 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 43.2836 | 5 | yes |
| GO:0006996 | organelle organization | 41.7910 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 38.8060 | 6 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 38.8060 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 38.8060 | 4 | no |
| GO:0051049 | regulation of transport | 38.8060 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 37.3134 | 5 | no |
| GO:0023056 | positive regulation of signaling | 37.3134 | 4 | no |
| GO:0031399 | regulation of protein modification process | 34.3284 | 6 | yes |
| GO:0042325 | regulation of phosphorylation | 34.3284 | 7 | yes |
| GO:0008104 | protein localization | 32.8358 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 32.8358 | 5 | no |
| GO:0022607 | cellular component assembly | 32.8358 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 32.8358 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 32.8358 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 31.3433 | 7 | yes |
| GO:0009892 | negative regulation of metabolic process | 31.3433 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 31.3433 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 29.8507 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 29.8507 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 29.8507 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 28.3582 | 5 | no |
| GO:0060341 | regulation of cellular localization | 28.3582 | 4 | no |
| GO:0010563 | negative regulation of phosphorus metabolic process | 26.8657 | 6 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.8657 | 5 | yes |
| GO:0045936 | negative regulation of phosphate metabolic process | 26.8657 | 7 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 25.3731 | 6 | yes |
| GO:0051338 | regulation of transferase activity | 25.3731 | 4 | yes |
| GO:0036211 | protein modification process | 25.3731 | 4 | no |
| GO:0043412 | macromolecule modification | 25.3731 | 4 | no |
| GO:0032880 | regulation of protein localization | 25.3731 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 25.3731 | 4 | no |
| GO:0043933 | protein-containing complex organization | 25.3731 | 4 | no |
| GO:0031400 | negative regulation of protein modification process | 23.8806 | 7 | yes |
| GO:0042326 | negative regulation of phosphorylation | 23.8806 | 8 | yes |
| GO:0043549 | regulation of kinase activity | 23.8806 | 5 | yes |
| GO:0043067 | regulation of programmed cell death | 23.8806 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 23.8806 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 23.8806 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 23.8806 | 5 | no |
| GO:0051050 | positive regulation of transport | 23.8806 | 4 | no |
| GO:0045859 | regulation of protein kinase activity | 22.3881 | 6 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 22.3881 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 22.3881 | 4 | yes |
| GO:0030030 | cell projection organization | 22.3881 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 22.3881 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 22.3881 | 5 | no |
| GO:0010468 | regulation of gene expression | 22.3881 | 6 | no |
| GO:0043269 | regulation of monoatomic ion transport | 22.3881 | 5 | no |
| GO:0001933 | negative regulation of protein phosphorylation | 20.8955 | 8 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 20.8955 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 20.8955 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 20.8955 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 20.8955 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 20.8955 | 7 | no |
| GO:0141124 | intracellular signaling cassette | 20.8955 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 20.8955 | 5 | no |
| GO:0010959 | regulation of metal ion transport | 20.8955 | 6 | no |
| GO:0071310 | cellular response to organic substance | 20.8955 | 4 | no |
| GO:0034762 | regulation of transmembrane transport | 20.8955 | 4 | no |
| GO:0044057 | regulation of system process | 20.8955 | 4 | no |
| GO:0043086 | negative regulation of catalytic activity | 19.4030 | 4 | yes |
| GO:0050890 | cognition | 16.4179 | 4 | yes |
| GO:0071900 | regulation of protein serine/threonine kinase activity | 16.4179 | 7 | yes |
| GO:0033673 | negative regulation of kinase activity | 14.9254 | 6 | yes |
| GO:0051348 | negative regulation of transferase activity | 14.9254 | 5 | yes |
| GO:0006469 | negative regulation of protein kinase activity | 13.4328 | 7 | yes |
| GO:0071901 | negative regulation of protein serine/threonine kinase activity | 10.4478 | 8 | yes |
| GO:0007612 | learning | 7.4627 | 4 | yes |
| GO:2000479 | regulation of cAMP-dependent protein kinase activity | 7.4627 | 8 | yes |
| GO:2000480 | negative regulation of cAMP-dependent protein kinase activity | 7.4627 | 9 | yes |
| GO:0006631 | fatty acid metabolic process | 4.4776 | 4 | yes |
| GO:0019752 | carboxylic acid metabolic process | 4.4776 | 5 | yes |
| GO:0032787 | monocarboxylic acid metabolic process | 4.4776 | 6 | yes |
| GO:0043436 | oxoacid metabolic process | 4.4776 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CFA91_HUMAN | [view interactions] | Low throughput | no | no |
| RYR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KAP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BIG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | Low throughput | no | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AKAP5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AKA11_HUMAN | [view interactions] | Low throughput | no | yes |
| GNAO_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TNR1A_HUMAN | [view interactions] | Low throughput | no | yes |
| GNAI3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| USO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCH1_HUMAN | [view interactions] | High throughput | no | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKAP9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKP13_HUMAN | [view interactions] | High throughput | no | yes |
| PLAK2_HUMAN | [view interactions] | High throughput | no | no |
| MTAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAA25_HUMAN | [view interactions] | High throughput | no | yes |
| VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KC1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CP131_HUMAN | [view interactions] | High throughput | no | no |
| HBP1_HUMAN | [view interactions] | High throughput | no | yes |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| IQCN_HUMAN | [view interactions] | High throughput | no | no |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| TIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HPT_HUMAN | [view interactions] | High throughput | no | no |
| TRFE_HUMAN | [view interactions] | High throughput | no | no |
| H12_HUMAN | [view interactions] | High throughput | no | yes |
| FIBG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTN22_HUMAN | [view interactions] | High throughput | no | yes |
| CEP57_HUMAN | [view interactions] | High throughput | no | yes |
| TOX2_HUMAN | [view interactions] | High throughput | no | no |
| DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SCML1_HUMAN | [view interactions] | High throughput | no | no |
| FGOP2_HUMAN | [view interactions] | High throughput | no | yes |
| RN145_HUMAN | [view interactions] | High throughput | no | yes |
| COQ3_HUMAN | [view interactions] | High throughput | no | no |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CCD71_HUMAN | [view interactions] | High throughput | no | no |
| DUS16_HUMAN | [view interactions] | High throughput | no | yes |
| DYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MACA2_HUMAN | [view interactions] | High throughput | no | no |
| CTCFL_HUMAN | [view interactions] | High throughput | no | no |
| UBE3C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZHX1R_HUMAN | [view interactions] | High throughput | no | yes |
| PIGF_HUMAN | [view interactions] | High throughput | no | no |
| IT70B_HUMAN | [view interactions] | High throughput | no | no |
| MD2BP_HUMAN | [view interactions] | High throughput | no | no |
| LRC49_HUMAN | [view interactions] | High throughput | no | no |
| KIFA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CARD9_HUMAN | [view interactions] | High throughput | no | no |
| TLS1_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| PDPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYCBP_HUMAN | [view interactions] | High throughput | no | yes |
| GNAI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCAF7_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| LASP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXD2_HUMAN | [view interactions] | High throughput | no | yes |
| FIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKBP8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAVS_HUMAN | [view interactions] | High throughput | no | yes |
| MFN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTCH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
| PTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIRO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RMD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S2546_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEX14_HUMAN | [view interactions] | High throughput | no | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NBEA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK5P2_HUMAN | [view interactions] | High throughput | no | yes |
| KAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| KAPCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OFD1_HUMAN | [view interactions] | High throughput | no | yes |
| BABA1_HUMAN | [view interactions] | High throughput | no | yes |
| SC16A_HUMAN | [view interactions] | High throughput | no | yes |
| CCD77_HUMAN | [view interactions] | High throughput | no | yes |
| PCM1_HUMAN | [view interactions] | High throughput | no | yes |
| CEP72_HUMAN | [view interactions] | High throughput | no | yes |
| CSN7A_HUMAN | [view interactions] | High throughput | no | yes |
| CEP68_HUMAN | [view interactions] | High throughput | no | yes |
| SURF4_HUMAN | [view interactions] | High throughput | no | yes |
| VAV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CE170_HUMAN | [view interactions] | High throughput | no | yes |
| KC1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| CXB7_HUMAN | [view interactions] | High throughput | no | no |
| ZN707_HUMAN | [view interactions] | High throughput | no | yes |
| SP17_HUMAN | [view interactions] | High throughput | no | no |
| AKA28_HUMAN | [view interactions] | High throughput | no | no |
| AMY1B_HUMAN | [view interactions] | High throughput | no | no |
| AMY1A_HUMAN | [view interactions] | High throughput | no | no |
| AMY1C_HUMAN | [view interactions] | High throughput | no | no |
| KAP0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKX_HUMAN | [view interactions] | High throughput | no | yes |
| CRBG3_HUMAN | [view interactions] | High throughput | no | no |
| PAUF_HUMAN | [view interactions] | High throughput | no | no |
| AKA7G_HUMAN | [view interactions] | High throughput | no | yes |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAPCG_HUMAN | [view interactions] | High throughput | no | no |
| ROP1A_HUMAN | [view interactions] | High throughput | no | no |
| SSX2_HUMAN | [view interactions] | High throughput | no | no |
| ALX3_HUMAN | [view interactions] | High throughput | no | no |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| NMDZ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC1_HUMAN | [view interactions] | High throughput | no | no |
| ARGL1_HUMAN | [view interactions] | High throughput | no | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TX101_HUMAN | [view interactions] | High throughput | no | no |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEP63_HUMAN | [view interactions] | High throughput | no | yes |
| POC5_HUMAN | [view interactions] | High throughput | no | yes |
| KINH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ECM1_HUMAN | [view interactions] | High throughput | no | no |
| TAF12_HUMAN | [view interactions] | High throughput | no | yes |
| SMAKA_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOM20_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOM22_HUMAN | [view interactions] | High throughput | no | yes |
| AKA10_HUMAN | [view interactions] | High throughput | no | no |
| PK1IP_HUMAN | [view interactions] | High throughput | no | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |