KAP3_HUMAN
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in KAP3_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 34.6154 | 4 | yes |
GO:0032555 | purine ribonucleotide binding | 34.6154 | 4 | yes |
GO:0046872 | metal ion binding | 33.3333 | 4 | no |
GO:0019900 | kinase binding | 28.2051 | 4 | yes |
GO:0019901 | protein kinase binding | 26.9231 | 5 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 26.9231 | 4 | no |
GO:0030554 | adenyl nucleotide binding | 25.6410 | 5 | yes |
GO:0032559 | adenyl ribonucleotide binding | 25.6410 | 5 | yes |
GO:0019887 | protein kinase regulator activity | 12.8205 | 4 | yes |
GO:0031625 | ubiquitin protein ligase binding | 11.5385 | 5 | yes |
GO:0044389 | ubiquitin-like protein ligase binding | 11.5385 | 4 | yes |
GO:0034236 | protein kinase A catalytic subunit binding | 8.9744 | 4 | yes |
GO:0004860 | protein kinase inhibitor activity | 7.6923 | 5 | yes |
GO:0004862 | cAMP-dependent protein kinase inhibitor activity | 7.6923 | 6 | yes |
GO:0008603 | cAMP-dependent protein kinase regulator activity | 7.6923 | 5 | yes |
GO:0019210 | kinase inhibitor activity | 7.6923 | 4 | yes |
GO:0030291 | protein serine/threonine kinase inhibitor activity | 7.6923 | 6 | yes |
GO:0030551 | cyclic nucleotide binding | 7.6923 | 4 | yes |
GO:0030552 | cAMP binding | 7.6923 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in KAP3_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 58.9744 | 4 | no |
GO:0010646 | regulation of cell communication | 56.4103 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 53.8462 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 53.8462 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 52.5641 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 52.5641 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | yes |
GO:0051246 | regulation of protein metabolic process | 50.0000 | 5 | yes |
GO:0009966 | regulation of signal transduction | 46.1538 | 4 | no |
GO:0051174 | regulation of phosphorus metabolic process | 42.3077 | 5 | yes |
GO:0019220 | regulation of phosphate metabolic process | 42.3077 | 6 | yes |
GO:0009893 | positive regulation of metabolic process | 41.0256 | 4 | no |
GO:0051049 | regulation of transport | 37.1795 | 4 | no |
GO:0031399 | regulation of protein modification process | 37.1795 | 6 | yes |
GO:0042325 | regulation of phosphorylation | 37.1795 | 7 | yes |
GO:0006996 | organelle organization | 34.6154 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
GO:0022607 | cellular component assembly | 33.3333 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 32.0513 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 32.0513 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 32.0513 | 6 | no |
GO:0001932 | regulation of protein phosphorylation | 32.0513 | 7 | yes |
GO:0051128 | regulation of cellular component organization | 30.7692 | 4 | no |
GO:0010647 | positive regulation of cell communication | 29.4872 | 5 | no |
GO:0023056 | positive regulation of signaling | 29.4872 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 29.4872 | 5 | no |
GO:0043085 | positive regulation of catalytic activity | 29.4872 | 4 | no |
GO:0010243 | response to organonitrogen compound | 29.4872 | 4 | yes |
GO:0008104 | protein localization | 28.2051 | 4 | no |
GO:0051050 | positive regulation of transport | 28.2051 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 28.2051 | 4 | yes |
GO:0010468 | regulation of gene expression | 26.9231 | 5 | no |
GO:0006796 | phosphate-containing compound metabolic process | 26.9231 | 4 | no |
GO:0036211 | protein modification process | 26.9231 | 4 | no |
GO:0043412 | macromolecule modification | 26.9231 | 4 | no |
GO:0050804 | modulation of chemical synaptic transmission | 25.6410 | 5 | yes |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 25.6410 | 5 | yes |
GO:0051338 | regulation of transferase activity | 25.6410 | 4 | yes |
GO:0099177 | regulation of trans-synaptic signaling | 25.6410 | 4 | yes |
GO:0071310 | cellular response to organic substance | 25.6410 | 4 | no |
GO:0010941 | regulation of cell death | 25.6410 | 4 | no |
GO:0031324 | negative regulation of cellular metabolic process | 25.6410 | 5 | yes |
GO:0030030 | cell projection organization | 24.3590 | 4 | no |
GO:0060341 | regulation of cellular localization | 24.3590 | 4 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 24.3590 | 6 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 24.3590 | 7 | no |
GO:0043067 | regulation of programmed cell death | 24.3590 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 24.3590 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 24.3590 | 5 | yes |
GO:0043933 | protein-containing complex organization | 23.0769 | 4 | no |
GO:0031401 | positive regulation of protein modification process | 23.0769 | 7 | no |
GO:0042327 | positive regulation of phosphorylation | 23.0769 | 8 | no |
GO:0042981 | regulation of apoptotic process | 23.0769 | 6 | no |
GO:0014070 | response to organic cyclic compound | 23.0769 | 4 | yes |
GO:0043549 | regulation of kinase activity | 23.0769 | 5 | yes |
GO:0051248 | negative regulation of protein metabolic process | 21.7949 | 6 | yes |
GO:0120036 | plasma membrane bounded cell projection organization | 21.7949 | 5 | no |
GO:0009967 | positive regulation of signal transduction | 21.7949 | 5 | no |
GO:0043269 | regulation of ion transport | 20.5128 | 5 | no |
GO:0001934 | positive regulation of protein phosphorylation | 20.5128 | 8 | no |
GO:0051336 | regulation of hydrolase activity | 20.5128 | 4 | no |
GO:1901701 | cellular response to oxygen-containing compound | 20.5128 | 4 | no |
GO:0010563 | negative regulation of phosphorus metabolic process | 20.5128 | 6 | yes |
GO:0031400 | negative regulation of protein modification process | 20.5128 | 7 | yes |
GO:0045859 | regulation of protein kinase activity | 20.5128 | 6 | yes |
GO:0045936 | negative regulation of phosphate metabolic process | 20.5128 | 7 | yes |
GO:0050890 | cognition | 16.6667 | 4 | yes |
GO:0043086 | negative regulation of catalytic activity | 16.6667 | 4 | yes |
GO:0042326 | negative regulation of phosphorylation | 15.3846 | 8 | yes |
GO:0001933 | negative regulation of protein phosphorylation | 14.1026 | 8 | yes |
GO:0071900 | regulation of protein serine/threonine kinase activity | 12.8205 | 7 | yes |
GO:0007612 | learning | 8.9744 | 4 | yes |
GO:0051348 | negative regulation of transferase activity | 7.6923 | 5 | yes |
GO:2000479 | regulation of cAMP-dependent protein kinase activity | 7.6923 | 8 | yes |
GO:0006469 | negative regulation of protein kinase activity | 7.6923 | 7 | yes |
GO:0033673 | negative regulation of kinase activity | 7.6923 | 6 | yes |
GO:0071901 | negative regulation of protein serine/threonine kinase activity | 6.4103 | 8 | yes |
GO:2000480 | negative regulation of cAMP-dependent protein kinase activity | 6.4103 | 9 | yes |
GO:0097338 | response to clozapine | 3.8462 | 5 | yes |
GO:0019752 | carboxylic acid metabolic process | 3.8462 | 5 | yes |
GO:0043436 | oxoacid metabolic process | 3.8462 | 4 | yes |
GO:0006631 | fatty acid metabolic process | 2.5641 | 4 | yes |
GO:0032787 | monocarboxylic acid metabolic process | 2.5641 | 6 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in KAP3_HUMAN |
---|---|---|---|---|
DOID:0050700 | cardiomyopathy | 5.1282 | 4 | no |
DOID:0060036 | intrinsic cardiomyopathy | 5.1282 | 5 | no |
DOID:114 | heart disease | 5.1282 | 3 | no |
DOID:2843 | long QT syndrome | 3.8462 | 6 | no |
DOID:0060674 | catecholaminergic polymorphic ventricular tachycardia | 2.5641 | 5 | no |
DOID:10273 | heart conduction disease | 2.5641 | 4 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
LRRK2_HUMAN | [view interactions] | Low throughput | no | yes |
KAPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AKA11_HUMAN | [view interactions] | Low throughput | no | yes |
AKAP5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GNAO_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TNR1A_HUMAN | [view interactions] | Low throughput | no | yes |
GNAI3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CFA91_HUMAN | [view interactions] | Low throughput | no | no |
RYR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KAP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
BIG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KAPCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYOME_HUMAN | [view interactions] | High throughput | no | no |
KAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CK5P2_HUMAN | [view interactions] | High throughput | no | yes |
CCD77_HUMAN | [view interactions] | High throughput | no | yes |
CE170_HUMAN | [view interactions] | High throughput | no | yes |
VAV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SURF4_HUMAN | [view interactions] | High throughput | no | yes |
CEP68_HUMAN | [view interactions] | High throughput | no | yes |
CSN7A_HUMAN | [view interactions] | High throughput | no | yes |
PCM1_HUMAN | [view interactions] | High throughput | no | yes |
CEP72_HUMAN | [view interactions] | High throughput | no | yes |
SC16A_HUMAN | [view interactions] | High throughput | no | yes |
BABA1_HUMAN | [view interactions] | High throughput | no | yes |
OFD1_HUMAN | [view interactions] | High throughput | no | yes |
MIB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KC1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
CXB7_HUMAN | [view interactions] | High throughput | no | no |
ZN707_HUMAN | [view interactions] | High throughput | no | yes |
AKA28_HUMAN | [view interactions] | High throughput | no | no |
SP17_HUMAN | [view interactions] | High throughput | no | no |
KAP0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AKA7G_HUMAN | [view interactions] | High throughput | no | yes |
ZG16B_HUMAN | [view interactions] | High throughput | no | no |
CRBG3_HUMAN | [view interactions] | High throughput | no | no |
PRKX_HUMAN | [view interactions] | High throughput | no | yes |
KAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AMY1B_HUMAN | [view interactions] | High throughput | no | no |
AMY1A_HUMAN | [view interactions] | High throughput | no | no |
AMY1C_HUMAN | [view interactions] | High throughput | no | no |
MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KAPCG_HUMAN | [view interactions] | High throughput | no | no |
ROP1A_HUMAN | [view interactions] | High throughput | no | no |
SSX2_HUMAN | [view interactions] | High throughput | no | no |
ALX3_HUMAN | [view interactions] | High throughput | no | no |
SOX2_HUMAN | [view interactions] | High throughput | no | yes |
NMDZ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HDAC1_HUMAN | [view interactions] | High throughput | no | no |
ARGL1_HUMAN | [view interactions] | High throughput | no | yes |
CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TX101_HUMAN | [view interactions] | High throughput | no | no |
ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KINH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ECM1_HUMAN | [view interactions] | High throughput | no | no |
TAF12_HUMAN | [view interactions] | High throughput | no | yes |
SMAKA_HUMAN | [view interactions] | High throughput | no | yes |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TOM20_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TOM22_HUMAN | [view interactions] | High throughput | no | yes |
AKA10_HUMAN | [view interactions] | High throughput | no | no |
PK1IP_HUMAN | [view interactions] | High throughput | no | yes |
NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
USO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GCH1_HUMAN | [view interactions] | High throughput | no | no |
AKAP9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AKP13_HUMAN | [view interactions] | High throughput | no | yes |
AKAP2_HUMAN | [view interactions] | High throughput | no | no |
MTAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NAA25_HUMAN | [view interactions] | High throughput | no | yes |
VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KC1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CP131_HUMAN | [view interactions] | High throughput | no | no |
HBP1_HUMAN | [view interactions] | High throughput | no | yes |
HERC2_HUMAN | [view interactions] | High throughput | no | yes |
IQCN_HUMAN | [view interactions] | High throughput | no | no |
HAX1_HUMAN | [view interactions] | High throughput | no | no |
AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRI25_HUMAN | [view interactions] | High throughput | no | yes |
NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
ATX1_HUMAN | [view interactions] | High throughput | no | yes |
TIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HPT_HUMAN | [view interactions] | High throughput | no | no |
TRFE_HUMAN | [view interactions] | High throughput | no | no |
H12_HUMAN | [view interactions] | High throughput | no | yes |
FIBG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PTN22_HUMAN | [view interactions] | High throughput | no | yes |
CEP57_HUMAN | [view interactions] | High throughput | no | yes |
TOX2_HUMAN | [view interactions] | High throughput | no | no |
DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SCML1_HUMAN | [view interactions] | High throughput | no | no |
FGOP2_HUMAN | [view interactions] | High throughput | no | yes |
RN145_HUMAN | [view interactions] | High throughput | no | yes |
COQ3_HUMAN | [view interactions] | High throughput | no | no |
GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CCD71_HUMAN | [view interactions] | High throughput | no | no |
DUS16_HUMAN | [view interactions] | High throughput | no | yes |
DYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
K0895_HUMAN | [view interactions] | High throughput | no | no |
CTCFL_HUMAN | [view interactions] | High throughput | no | no |
UBE3C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZHX1R_HUMAN | [view interactions] | High throughput | no | yes |
PIGF_HUMAN | [view interactions] | High throughput | no | no |
TT30B_HUMAN | [view interactions] | High throughput | no | no |
MD2BP_HUMAN | [view interactions] | High throughput | no | no |
LRC49_HUMAN | [view interactions] | High throughput | no | no |
KIFA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CARD9_HUMAN | [view interactions] | High throughput | no | no |
OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYCBP_HUMAN | [view interactions] | High throughput | no | yes |
GNAI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DCAF7_HUMAN | [view interactions] | High throughput | no | yes |
DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
LASP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EXD2_HUMAN | [view interactions] | High throughput | no | yes |
FIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FKBP8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MAVS_HUMAN | [view interactions] | High throughput | no | yes |
MFN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MTCH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
PTN1_HUMAN | [view interactions] | High throughput | no | yes |
MIRO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RMD3_HUMAN | [view interactions] | High throughput | no | yes |
S2546_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PEX14_HUMAN | [view interactions] | High throughput | no | yes |
NBEA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CCL11_HUMAN | [view interactions] | Computational | no | no |
AKAP8_HUMAN | [view interactions] | Computational | no | yes |
ADCY3_HUMAN | [view interactions] | Computational | no | yes |
PP1A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
STMN1_HUMAN | [view interactions] | Computational | no | yes |
EZRI_HUMAN | [view entry] [view interactions] | Computational | yes | no |
BAD_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CD3Z_HUMAN | [view interactions] | Computational | no | no |
CREM_HUMAN | [view interactions] | Computational | no | no |
THRB_HUMAN | [view interactions] | Computational | no | no |
ADCY4_HUMAN | [view interactions] | Computational | no | yes |
MK03_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GBB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MPIP3_HUMAN | [view interactions] | Computational | no | yes |
NOS1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
FAK1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ADCY1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
GBG1_HUMAN | [view interactions] | Computational | no | no |
2A5D_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NPY4R_HUMAN | [view interactions] | Computational | no | yes |
PPR1B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
TLN1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
CREB1_HUMAN | [view interactions] | Computational | no | yes |
AKAP3_HUMAN | [view interactions] | Computational | no | no |
CND1_HUMAN | [view interactions] | Computational | no | yes |
ADCY8_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PKN1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MLC1_HUMAN | [view interactions] | Computational | no | no |
BCL2_HUMAN | [view interactions] | Computational | no | no |
NHRF1_HUMAN | [view interactions] | Computational | no | no |
CDK1_HUMAN | [view interactions] | Computational | no | no |
ADRB2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
ANGT_HUMAN | [view interactions] | Computational | no | no |
ADCY6_HUMAN | [view interactions] | Computational | no | yes |
ADCY7_HUMAN | [view interactions] | Computational | no | yes |
CD2_HUMAN | [view interactions] | Computational | no | no |
SDF1_HUMAN | [view interactions] | Computational | no | no |
RHOA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ITA1_HUMAN | [view interactions] | Computational | no | yes |
GNAS1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CSK_HUMAN | [view interactions] | Computational | no | yes |
PAXI_HUMAN | [view interactions] | Computational | no | yes |
MLXPL_HUMAN | [view interactions] | Computational | no | no |
CCL4_HUMAN | [view interactions] | Computational | no | no |
ITB1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
ADCY5_HUMAN | [view interactions] | Computational | no | no |
CFTR_HUMAN | [view interactions] | Computational | no | no |
KPCE_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
B2CL1_HUMAN | [view interactions] | Computational | no | yes |
ADCY9_HUMAN | [view interactions] | Computational | no | yes |
CCNB1_HUMAN | [view interactions] | Computational | no | no |
RPGF4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
EDN1_HUMAN | [view interactions] | Computational | no | no |
AAKG1_HUMAN | [view interactions] | Computational | no | no |
LIPS_HUMAN | [view entry] [view interactions] | Computational | yes | no |