BIG2_HUMAN
Evidence for PS localization
Functions
Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in BIG2_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 36.5854 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 36.5854 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 31.7073 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 31.7073 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 31.7073 | 6 | no |
| GO:0003924 | GTPase activity | 29.2683 | 7 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 29.2683 | 4 | no |
| GO:0005525 | GTP binding | 26.8293 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 26.8293 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 26.8293 | 5 | no |
| GO:0017022 | myosin binding | 7.3171 | 4 | yes |
| GO:0005085 | guanyl-nucleotide exchange factor activity | 4.8780 | 5 | yes |
| GO:0030695 | GTPase regulator activity | 4.8780 | 4 | yes |
| GO:0050811 | GABA receptor binding | 4.8780 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in BIG2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 53.6585 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 51.2195 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 46.3415 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 43.9024 | 4 | no |
| GO:0008104 | protein localization | 41.4634 | 4 | yes |
| GO:0010646 | regulation of cell communication | 41.4634 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 41.4634 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 41.4634 | 4 | no |
| GO:0022607 | cellular component assembly | 39.0244 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 39.0244 | 4 | no |
| GO:0006996 | organelle organization | 36.5854 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 36.5854 | 4 | yes |
| GO:0051049 | regulation of transport | 36.5854 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 36.5854 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 34.1463 | 4 | yes |
| GO:0010468 | regulation of gene expression | 31.7073 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 31.7073 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 31.7073 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 29.2683 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 29.2683 | 5 | no |
| GO:0023056 | positive regulation of signaling | 29.2683 | 4 | no |
| GO:0031399 | regulation of protein modification process | 29.2683 | 6 | no |
| GO:0009892 | negative regulation of metabolic process | 29.2683 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 26.8293 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 26.8293 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.8293 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 26.8293 | 5 | no |
| GO:0010243 | response to organonitrogen compound | 26.8293 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.8293 | 5 | no |
| GO:0030030 | cell projection organization | 26.8293 | 4 | no |
| GO:0015031 | protein transport | 24.3902 | 4 | yes |
| GO:0071702 | organic substance transport | 24.3902 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 24.3902 | 4 | yes |
| GO:0060341 | regulation of cellular localization | 24.3902 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 24.3902 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 24.3902 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 24.3902 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 24.3902 | 5 | no |
| GO:0007010 | cytoskeleton organization | 24.3902 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 21.9512 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 21.9512 | 5 | yes |
| GO:0001932 | regulation of protein phosphorylation | 21.9512 | 7 | no |
| GO:0031401 | positive regulation of protein modification process | 21.9512 | 7 | no |
| GO:0042325 | regulation of phosphorylation | 21.9512 | 7 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 21.9512 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 21.9512 | 5 | no |
| GO:0032880 | regulation of protein localization | 21.9512 | 5 | no |
| GO:0071310 | cellular response to organic substance | 21.9512 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 21.9512 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 21.9512 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 21.9512 | 5 | no |
| GO:0010628 | positive regulation of gene expression | 17.0732 | 6 | yes |
| GO:0016050 | vesicle organization | 14.6341 | 5 | yes |
| GO:0001817 | regulation of cytokine production | 12.1951 | 4 | yes |
| GO:0001819 | positive regulation of cytokine production | 9.7561 | 5 | yes |
| GO:0006887 | exocytosis | 9.7561 | 4 | yes |
| GO:0046903 | secretion | 9.7561 | 4 | yes |
| GO:0098876 | vesicle-mediated transport to the plasma membrane | 9.7561 | 4 | yes |
| GO:0007032 | endosome organization | 7.3171 | 6 | yes |
| GO:0032680 | regulation of tumor necrosis factor production | 4.8780 | 6 | yes |
| GO:0032760 | positive regulation of tumor necrosis factor production | 4.8780 | 7 | yes |
| GO:0048193 | Golgi vesicle transport | 4.8780 | 5 | yes |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 4.8780 | 6 | yes |
| GO:1903555 | regulation of tumor necrosis factor superfamily cytokine production | 4.8780 | 5 | yes |
| GO:1903557 | positive regulation of tumor necrosis factor superfamily cytokine production | 4.8780 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in BIG2_HUMAN |
|---|---|---|---|---|
| DOID:114 | heart disease | 4.8780 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| EXOC7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MYCBP_HUMAN | [view interactions] | Low throughput | no | yes |
| GBRB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GBRB3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GBRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KAP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYT3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GBRA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BIG1_HUMAN | [view interactions] | Low throughput | no | yes |
| TNR1A_HUMAN | [view interactions] | Low throughput | no | yes |
| PP1G_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KAP0_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KAP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PLPL2_HUMAN | [view interactions] | Low throughput | no | no |
| FKBP2_HUMAN | [view interactions] | Low throughput | no | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ITCH_HUMAN | [view interactions] | Low throughput | no | yes |
| FLNA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PR40A_HUMAN | [view interactions] | High throughput | no | yes |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| PDCD1_HUMAN | [view interactions] | High throughput | no | yes |
| MADCA_HUMAN | [view interactions] | High throughput | no | no |
| GLPB_HUMAN | [view interactions] | High throughput | no | no |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| ICAM1_HUMAN | [view interactions] | High throughput | no | no |
| SIGL1_HUMAN | [view interactions] | High throughput | no | no |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| MRAP2_HUMAN | [view interactions] | High throughput | no | no |
| VASN_HUMAN | [view interactions] | High throughput | no | yes |
| F131B_HUMAN | [view interactions] | High throughput | no | no |
| CAB45_HUMAN | [view interactions] | High throughput | no | yes |
| TMM9B_HUMAN | [view interactions] | High throughput | no | yes |
| CGAT1_HUMAN | [view interactions] | High throughput | no | no |
| DTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| VAV_HUMAN | [view interactions] | High throughput | no | no |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| PDE3A_HUMAN | [view interactions] | High throughput | no | no |
| CLUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SACA1_HUMAN | [view interactions] | High throughput | no | no |
| TM171_HUMAN | [view interactions] | High throughput | no | yes |
| DNJB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD244_HUMAN | [view interactions] | High throughput | no | no |
| SLAF1_HUMAN | [view interactions] | High throughput | no | no |
| HLAE_HUMAN | [view interactions] | High throughput | no | no |
| LRAD4_HUMAN | [view interactions] | High throughput | no | yes |
| CD79B_HUMAN | [view interactions] | High throughput | no | no |
| EDNRB_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| CTDP1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| HPPD_HUMAN | [view interactions] | High throughput | no | no |
| LRC31_HUMAN | [view interactions] | High throughput | no | no |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OPALI_HUMAN | [view interactions] | High throughput | no | yes |
| KCNH4_HUMAN | [view interactions] | High throughput | no | no |
| OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
| CLC4A_HUMAN | [view interactions] | High throughput | no | no |
| CYB5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRC25_HUMAN | [view interactions] | High throughput | no | yes |
| CC018_HUMAN | [view interactions] | High throughput | no | yes |
| F234A_HUMAN | [view interactions] | High throughput | no | yes |
| FPR1_HUMAN | [view interactions] | High throughput | no | no |
| GPR17_HUMAN | [view interactions] | High throughput | no | no |
| CRCM1_HUMAN | [view interactions] | High throughput | no | yes |
| PBIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RM23_HUMAN | [view interactions] | High throughput | no | yes |
| HEN2_HUMAN | [view interactions] | High throughput | no | no |
| K1C16_HUMAN | [view interactions] | High throughput | no | no |
| TMEM9_HUMAN | [view interactions] | High throughput | no | no |
| ITA8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TNR5_HUMAN | [view interactions] | High throughput | no | no |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| K2C73_HUMAN | [view interactions] | High throughput | no | no |
| KLRB1_HUMAN | [view interactions] | High throughput | no | yes |
| CLC2B_HUMAN | [view interactions] | High throughput | no | yes |
| CLC2D_HUMAN | [view interactions] | High throughput | no | yes |
| MFD4A_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VSIG4_HUMAN | [view interactions] | High throughput | no | no |
| UPK2_HUMAN | [view interactions] | High throughput | no | no |
| SGCA_HUMAN | [view interactions] | High throughput | no | yes |
| GRAH_HUMAN | [view interactions] | High throughput | no | no |
| TBB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| HUMMR_HUMAN | [view interactions] | High throughput | no | yes |
| HLAC_HUMAN | [view interactions] | High throughput | no | no |
| ANM6_HUMAN | [view interactions] | High throughput | no | yes |
| STK16_HUMAN | [view interactions] | High throughput | no | no |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| AKA10_HUMAN | [view interactions] | High throughput | no | no |
| DPY30_HUMAN | [view interactions] | High throughput | no | yes |
| CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRS10_HUMAN | [view interactions] | High throughput | no | yes |
| PSD13_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD3_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD4_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| FLNC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NUP98_HUMAN | [view interactions] | High throughput | no | no |
| NUP88_HUMAN | [view interactions] | High throughput | no | yes |
| PAF1_HUMAN | [view interactions] | High throughput | no | yes |
| ANKY2_HUMAN | [view interactions] | High throughput | no | no |
| PLCA_HUMAN | [view interactions] | High throughput | no | yes |
| CNTP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SGPL1_HUMAN | [view interactions] | High throughput | no | yes |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RFFL_HUMAN | [view interactions] | High throughput | no | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| ELOV5_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ARF1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GNA12_HUMAN | [view interactions] | Computational | no | no |
| GBB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GBG1_HUMAN | [view interactions] | Computational | no | no |
| GNA13_HUMAN | [view entry] [view interactions] | Computational | yes | yes |