GBRA1_HUMAN
Evidence for PS localization
Functions
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed, PubMed, PubMed). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed, PubMed). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer . The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity (PubMed, PubMed). GABRA1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection . Functions also as histamine receptor and mediates cellular responses to histamine . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GBRA1_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 40.4040 | 4 | no |
| GO:0017076 | purine nucleotide binding | 40.4040 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 39.3939 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 39.3939 | 4 | no |
| GO:0043168 | anion binding | 39.3939 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 32.3232 | 6 | no |
| GO:0005524 | ATP binding | 31.3131 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 31.3131 | 5 | no |
| GO:0003723 | RNA binding | 28.2828 | 4 | no |
| GO:0043169 | cation binding | 24.2424 | 4 | no |
| GO:0046872 | metal ion binding | 24.2424 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 23.2323 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 23.2323 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 23.2323 | 6 | no |
| GO:0005216 | monoatomic ion channel activity | 13.1313 | 4 | yes |
| GO:0005230 | extracellular ligand-gated monoatomic ion channel activity | 13.1313 | 6 | yes |
| GO:0015103 | inorganic anion transmembrane transporter activity | 13.1313 | 4 | yes |
| GO:0015267 | channel activity | 13.1313 | 4 | yes |
| GO:0015276 | ligand-gated monoatomic ion channel activity | 13.1313 | 5 | yes |
| GO:0022824 | transmitter-gated monoatomic ion channel activity | 13.1313 | 5 | yes |
| GO:0022834 | ligand-gated channel activity | 13.1313 | 6 | yes |
| GO:0022835 | transmitter-gated channel activity | 13.1313 | 4 | yes |
| GO:0022836 | gated channel activity | 13.1313 | 5 | yes |
| GO:0004890 | GABA-A receptor activity | 12.1212 | 5 | yes |
| GO:0005253 | monoatomic anion channel activity | 12.1212 | 5 | yes |
| GO:0005254 | chloride channel activity | 12.1212 | 6 | yes |
| GO:0008509 | monoatomic anion transmembrane transporter activity | 12.1212 | 4 | yes |
| GO:0015108 | chloride transmembrane transporter activity | 12.1212 | 5 | yes |
| GO:0016917 | GABA receptor activity | 12.1212 | 4 | yes |
| GO:0022851 | GABA-gated chloride ion channel activity | 12.1212 | 6 | yes |
| GO:0099095 | ligand-gated monoatomic anion channel activity | 12.1212 | 6 | yes |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 11.1111 | 4 | yes |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 10.1010 | 5 | yes |
| GO:1904315 | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential | 10.1010 | 6 | yes |
| GO:0005237 | inhibitory extracellular ligand-gated monoatomic ion channel activity | 9.0909 | 7 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GBRA1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 40.4040 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 35.3535 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 35.3535 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 35.3535 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 33.3333 | 4 | no |
| GO:0010646 | regulation of cell communication | 32.3232 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 31.3131 | 4 | no |
| GO:0022607 | cellular component assembly | 30.3030 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 29.2929 | 4 | no |
| GO:0008104 | protein localization | 28.2828 | 4 | no |
| GO:0006996 | organelle organization | 28.2828 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 27.2727 | 4 | no |
| GO:0009966 | regulation of signal transduction | 27.2727 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.2626 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.2626 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 26.2626 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 25.2525 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 24.2424 | 5 | no |
| GO:0071310 | cellular response to organic substance | 23.2323 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 23.2323 | 4 | no |
| GO:0071702 | organic substance transport | 23.2323 | 4 | no |
| GO:0071705 | nitrogen compound transport | 22.2222 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 21.2121 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 21.2121 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 21.2121 | 4 | no |
| GO:0051049 | regulation of transport | 21.2121 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 20.2020 | 5 | no |
| GO:0010468 | regulation of gene expression | 20.2020 | 6 | no |
| GO:0099536 | synaptic signaling | 19.1919 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 19.1919 | 5 | yes |
| GO:0007268 | chemical synaptic transmission | 19.1919 | 7 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 19.1919 | 6 | yes |
| GO:0006811 | monoatomic ion transport | 15.1515 | 4 | yes |
| GO:0015698 | inorganic anion transport | 13.1313 | 4 | yes |
| GO:0034330 | cell junction organization | 13.1313 | 4 | yes |
| GO:0098661 | inorganic anion transmembrane transport | 13.1313 | 4 | yes |
| GO:1902476 | chloride transmembrane transport | 12.1212 | 5 | yes |
| GO:0006820 | monoatomic anion transport | 12.1212 | 5 | yes |
| GO:0006821 | chloride transport | 12.1212 | 5 | yes |
| GO:0007214 | gamma-aminobutyric acid signaling pathway | 12.1212 | 4 | yes |
| GO:0050808 | synapse organization | 12.1212 | 5 | yes |
| GO:0051932 | synaptic transmission, GABAergic | 12.1212 | 8 | yes |
| GO:0098656 | monoatomic anion transmembrane transport | 12.1212 | 4 | yes |
| GO:0060078 | regulation of postsynaptic membrane potential | 11.1111 | 4 | yes |
| GO:0034329 | cell junction assembly | 10.1010 | 5 | yes |
| GO:0007416 | synapse assembly | 9.0909 | 6 | yes |
| GO:1904862 | inhibitory synapse assembly | 7.0707 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GRM5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| P85A_HUMAN | [view interactions] | Low throughput | no | yes |
| BIG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TLR4_HUMAN | [view interactions] | Low throughput | no | yes |
| GBRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GBRG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CAD13_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MKLN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBRB3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| UBQL1_HUMAN | [view interactions] | Low throughput | no | yes |
| UBP14_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCG_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PP2BA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ENPL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| OS9_HUMAN | [view interactions] | Low throughput | no | yes |
| CALX_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TERA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYVN1_HUMAN | [view interactions] | Low throughput | no | yes |
| GBRB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GBRA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBRA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBRG3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
| CDKL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBPZ_HUMAN | [view interactions] | High throughput | no | no |
| GRIA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |
| GBRA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CD44_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX32_HUMAN | [view interactions] | High throughput | no | no |
| NLGN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GEPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NLGN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NBEA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRA4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBRA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NRX1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBRG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLH2_HUMAN | [view interactions] | High throughput | no | no |
| SERPH_HUMAN | [view interactions] | High throughput | no | no |
| S25A3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRKDC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| ADT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATD3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TXTP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DIC_HUMAN | [view interactions] | High throughput | no | yes |
| ATD3B_HUMAN | [view interactions] | High throughput | no | yes |
| S2513_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DJB11_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1C_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA8_HUMAN | [view interactions] | High throughput | no | yes |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB4A_HUMAN | [view interactions] | High throughput | no | yes |
| MIC60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
| TBB2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RCN2_HUMAN | [view interactions] | High throughput | no | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| TBB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| DPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PYR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGM1_HUMAN | [view interactions] | High throughput | no | no |
| UN45A_HUMAN | [view interactions] | High throughput | no | yes |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DNJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECD_HUMAN | [view interactions] | High throughput | no | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPN4_HUMAN | [view interactions] | High throughput | no | yes |
| MMTA2_HUMAN | [view interactions] | High throughput | no | yes |
| HSP76_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPF_HUMAN | [view interactions] | High throughput | no | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TIM50_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YES_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IRS4_HUMAN | [view interactions] | High throughput | no | no |
| GNAI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YTHD2_HUMAN | [view interactions] | High throughput | no | yes |
| PRS6B_HUMAN | [view interactions] | High throughput | no | yes |
| LG3BP_HUMAN | [view interactions] | High throughput | no | no |
| PDIA1_HUMAN | [view interactions] | High throughput | no | yes |
| PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| LMNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRS8_HUMAN | [view interactions] | High throughput | no | yes |
| KIF2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SVIL_HUMAN | [view interactions] | High throughput | no | yes |
| PCM1_HUMAN | [view interactions] | High throughput | no | yes |
| TCPE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBR5_HUMAN | [view interactions] | High throughput | no | no |
| DDX50_HUMAN | [view interactions] | High throughput | no | yes |
| SYFA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PR40A_HUMAN | [view interactions] | High throughput | no | no |
| LYRIC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRM1L_HUMAN | [view interactions] | High throughput | no | yes |
| TCPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL19_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLH22_HUMAN | [view interactions] | High throughput | no | no |
| RPOM_HUMAN | [view interactions] | High throughput | no | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GCN1_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S39A7_HUMAN | [view interactions] | High throughput | no | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| UBE3C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SE1L1_HUMAN | [view interactions] | High throughput | no | yes |
| TECR_HUMAN | [view interactions] | High throughput | no | yes |
| AT1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AT2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UGGG1_HUMAN | [view interactions] | High throughput | no | yes |
| HACD3_HUMAN | [view interactions] | High throughput | no | yes |
| ADT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC16A_HUMAN | [view interactions] | High throughput | no | yes |
| ERLN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LTN1_HUMAN | [view interactions] | High throughput | no | no |
| GANAB_HUMAN | [view interactions] | High throughput | no | yes |
| MAGD2_HUMAN | [view interactions] | High throughput | no | yes |
| MSH6_HUMAN | [view interactions] | High throughput | no | yes |
| ATX10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPG2_HUMAN | [view interactions] | High throughput | no | yes |
| USP9X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OST48_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX23_HUMAN | [view interactions] | High throughput | no | yes |
| SMC4_HUMAN | [view interactions] | High throughput | no | yes |
| ML12B_HUMAN | [view interactions] | High throughput | no | no |
| EIF3H_HUMAN | [view interactions] | High throughput | no | yes |
| RFC3_HUMAN | [view interactions] | High throughput | no | yes |
| RL35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRCH2_HUMAN | [view interactions] | High throughput | no | no |
| LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FUBP2_HUMAN | [view interactions] | High throughput | no | yes |
| RL27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RO52_HUMAN | [view interactions] | High throughput | no | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |