Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GBRA1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed, PubMed, PubMed). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed, PubMed). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer . The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity (PubMed, PubMed). GABRA1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection . Functions also as histamine receptor and mediates cellular responses to histamine . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GBRA1_HUMAN
GO:0016917 GABA receptor activity 45.4545 4 yes
GO:0004890 GABA-A receptor activity 42.4242 5 yes
GO:0005216 ion channel activity 42.4242 4 yes
GO:0005230 extracellular ligand-gated ion channel activity 42.4242 6 yes
GO:0005253 anion channel activity 42.4242 5 yes
GO:0005254 chloride channel activity 42.4242 6 yes
GO:0008509 anion transmembrane transporter activity 42.4242 4 yes
GO:0015103 inorganic anion transmembrane transporter activity 42.4242 4 yes
GO:0015108 chloride transmembrane transporter activity 42.4242 5 yes
GO:0015267 channel activity 42.4242 4 yes
GO:0015276 ligand-gated ion channel activity 42.4242 5 yes
GO:0022834 ligand-gated channel activity 42.4242 6 yes
GO:0022836 gated channel activity 42.4242 5 yes
GO:0022824 transmitter-gated ion channel activity 39.3939 5 yes
GO:0022835 transmitter-gated channel activity 39.3939 4 yes
GO:0022851 GABA-gated chloride ion channel activity 39.3939 5 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 39.3939 4 yes
GO:0099095 ligand-gated anion channel activity 39.3939 6 yes
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 36.3636 5 yes
GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential 36.3636 6 yes
GO:0005237 inhibitory extracellular ligand-gated ion channel activity 33.3333 7 yes
GO:0046872 metal ion binding 24.2424 4 no
GO:0017076 purine nucleotide binding 21.2121 4 no
GO:0032555 purine ribonucleotide binding 21.2121 4 no
GO:0035639 purine ribonucleoside triphosphate binding 21.2121 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in GBRA1_HUMAN
GO:0007268 chemical synaptic transmission 63.6364 6 yes
GO:0098916 anterograde trans-synaptic signaling 63.6364 5 yes
GO:0099537 trans-synaptic signaling 63.6364 4 yes
GO:0006811 ion transport 48.4848 4 yes
GO:0006820 anion transport 42.4242 5 yes
GO:0006821 chloride transport 42.4242 7 yes
GO:0015698 inorganic anion transport 42.4242 6 yes
GO:0098656 anion transmembrane transport 42.4242 4 yes
GO:0098660 inorganic ion transmembrane transport 42.4242 4 yes
GO:0098661 inorganic anion transmembrane transport 42.4242 5 yes
GO:1902476 chloride transmembrane transport 42.4242 6 yes
GO:0022607 cellular component assembly 36.3636 4 yes
GO:0051932 synaptic transmission, GABAergic 36.3636 7 yes
GO:0060078 regulation of postsynaptic membrane potential 36.3636 4 yes
GO:0010243 response to organonitrogen compound 36.3636 4 no
GO:0034330 cell junction organization 33.3333 4 yes
GO:0050808 synapse organization 33.3333 5 yes
GO:0008104 protein localization 33.3333 4 no
GO:0010646 regulation of cell communication 33.3333 4 no
GO:0048522 positive regulation of cellular process 30.3030 4 no
GO:0048523 negative regulation of cellular process 30.3030 4 no
GO:0060255 regulation of macromolecule metabolic process 30.3030 4 no
GO:0007416 synapse assembly 27.2727 6 yes
GO:0034329 cell junction assembly 27.2727 5 yes
GO:0031323 regulation of cellular metabolic process 27.2727 4 no
GO:0051171 regulation of nitrogen compound metabolic process 27.2727 4 no
GO:0071310 cellular response to organic substance 27.2727 4 no
GO:0080090 regulation of primary metabolic process 27.2727 4 no
GO:0036211 protein modification process 24.2424 4 no
GO:0043412 macromolecule modification 24.2424 4 no
GO:0048584 positive regulation of response to stimulus 24.2424 4 no
GO:0050804 modulation of chemical synaptic transmission 24.2424 5 no
GO:0099177 regulation of trans-synaptic signaling 24.2424 4 no
GO:0023056 positive regulation of signaling 24.2424 4 no
GO:0051246 regulation of protein metabolic process 24.2424 5 no
GO:0071417 cellular response to organonitrogen compound 24.2424 4 no
GO:1901699 cellular response to nitrogen compound 24.2424 4 no
GO:0009966 regulation of signal transduction 24.2424 4 no
GO:1904862 inhibitory synapse assembly 21.2121 7 yes
GO:0009893 positive regulation of metabolic process 21.2121 4 no
GO:0010604 positive regulation of macromolecule metabolic process 21.2121 5 no
GO:0051049 regulation of transport 21.2121 4 no
GO:0051128 regulation of cellular component organization 21.2121 4 no
GO:0010647 positive regulation of cell communication 21.2121 5 no
GO:0014070 response to organic cyclic compound 21.2121 4 no
GO:0016192 vesicle-mediated transport 21.2121 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GBRA1_HUMAN [view entry] [view interactions] Low throughput yes yes
GBRG3_HUMAN [view entry] [view interactions] Low throughput yes yes
GRM5_HUMAN [view entry] [view interactions] Low throughput yes no
P85A_HUMAN [view interactions] Low throughput no yes
BIG2_HUMAN [view entry] [view interactions] Low throughput yes yes
GBRB2_HUMAN [view entry] [view interactions] Low throughput yes no
GBRG2_HUMAN [view entry] [view interactions] Low throughput yes no
MKLN1_HUMAN [view interactions] Low throughput no yes
UBQL1_HUMAN [view interactions] Low throughput no yes
UBP14_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCG_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCD_HUMAN [view entry] [view interactions] Low throughput yes yes
PP2BA_HUMAN [view entry] [view interactions] Low throughput yes yes
ENPL_HUMAN [view entry] [view interactions] Low throughput yes yes
OS9_HUMAN [view interactions] Low throughput no yes
CALX_HUMAN [view entry] [view interactions] Low throughput yes yes
TERA_HUMAN [view entry] [view interactions] Low throughput yes yes
SYVN1_HUMAN [view interactions] Low throughput no yes
GBRB1_HUMAN [view entry] [view interactions] Low throughput yes no
GBRB3_HUMAN [view entry] [view interactions] Low throughput yes no
NLGN2_HUMAN [view entry] [view interactions] High throughput yes yes
GEPH_HUMAN [view entry] [view interactions] High throughput yes yes
GBRA3_HUMAN [view entry] [view interactions] High throughput yes yes
NLGN3_HUMAN [view entry] [view interactions] High throughput yes yes
NBEA_HUMAN [view entry] [view interactions] High throughput yes yes
GBRA4_HUMAN [view entry] [view interactions] High throughput yes no
GBRA5_HUMAN [view entry] [view interactions] High throughput yes no
NRX1A_HUMAN [view entry] [view interactions] High throughput yes no
GBRG1_HUMAN [view entry] [view interactions] High throughput yes yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
CLH2_HUMAN [view interactions] High throughput no no
OTUD4_HUMAN [view interactions] High throughput no yes
GBRA2_HUMAN [view entry] [view interactions] High throughput yes no
CD44_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
FBX32_HUMAN [view interactions] High throughput no no
DYN1_HUMAN [view entry] [view interactions] Computational yes yes
GBRA6_HUMAN [view entry] [view interactions] Computational yes no
GBRAP_HUMAN [view interactions] Computational no no
GBRT_HUMAN [view entry] [view interactions] Computational yes no
GABR2_HUMAN [view entry] [view interactions] Computational yes yes
TRAK2_HUMAN [view interactions] Computational no yes
CLCN2_HUMAN [view interactions] Computational no yes
NSF_HUMAN [view entry] [view interactions] Computational yes yes