Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GBRA2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed, PubMed). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed, PubMed). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer . The alpha2/beta2/gamma2 receptor exhibits synaptogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GBRA2_HUMAN
GO:0016917 GABA receptor activity 60.0000 4 yes
GO:0015267 channel activity 55.0000 4 yes
GO:0015276 ligand-gated ion channel activity 55.0000 5 yes
GO:0022824 transmitter-gated ion channel activity 55.0000 5 yes
GO:0022834 ligand-gated channel activity 55.0000 6 yes
GO:0022835 transmitter-gated channel activity 55.0000 4 yes
GO:0022836 gated channel activity 55.0000 5 yes
GO:0022851 GABA-gated chloride ion channel activity 55.0000 5 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 55.0000 4 yes
GO:0099095 ligand-gated anion channel activity 55.0000 6 yes
GO:0004890 GABA-A receptor activity 55.0000 5 yes
GO:0005216 ion channel activity 55.0000 4 yes
GO:0005230 extracellular ligand-gated ion channel activity 55.0000 6 yes
GO:0005253 anion channel activity 55.0000 5 yes
GO:0005254 chloride channel activity 55.0000 6 yes
GO:0008509 anion transmembrane transporter activity 55.0000 4 yes
GO:0015103 inorganic anion transmembrane transporter activity 55.0000 4 yes
GO:0015108 chloride transmembrane transporter activity 55.0000 5 yes
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 50.0000 5 yes
GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential 50.0000 6 yes
GO:0005237 inhibitory extracellular ligand-gated ion channel activity 45.0000 7 yes
GO:0008503 benzodiazepine receptor activity 30.0000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GBRA2_HUMAN
GO:0006811 ion transport 65.0000 4 yes
GO:0007268 chemical synaptic transmission 65.0000 6 yes
GO:0098916 anterograde trans-synaptic signaling 65.0000 5 yes
GO:0099537 trans-synaptic signaling 65.0000 4 yes
GO:0098660 inorganic ion transmembrane transport 60.0000 4 yes
GO:0006820 anion transport 55.0000 5 yes
GO:0006821 chloride transport 55.0000 7 yes
GO:0015698 inorganic anion transport 55.0000 6 yes
GO:0098656 anion transmembrane transport 55.0000 4 yes
GO:0098661 inorganic anion transmembrane transport 55.0000 5 yes
GO:1902476 chloride transmembrane transport 55.0000 6 yes
GO:0051932 synaptic transmission, GABAergic 45.0000 7 yes
GO:0034330 cell junction organization 40.0000 4 yes
GO:0050808 synapse organization 40.0000 5 yes
GO:0060078 regulation of postsynaptic membrane potential 40.0000 4 yes
GO:0022607 cellular component assembly 35.0000 4 yes
GO:0007416 synapse assembly 30.0000 6 yes
GO:0034329 cell junction assembly 30.0000 5 yes
GO:1904862 inhibitory synapse assembly 30.0000 7 yes
GO:0071310 cellular response to organic substance 30.0000 4 no
GO:0010243 response to organonitrogen compound 25.0000 4 no
GO:0014070 response to organic cyclic compound 25.0000 4 no
GO:0071407 cellular response to organic cyclic compound 25.0000 5 no
GO:0071417 cellular response to organonitrogen compound 25.0000 4 no
GO:1901699 cellular response to nitrogen compound 25.0000 4 no
GO:0048523 negative regulation of cellular process 25.0000 4 no
GO:0006836 neurotransmitter transport 10.0000 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
UBQL1_HUMAN [view interactions] Low throughput no yes
GBRG2_HUMAN [view entry] [view interactions] Low throughput yes no
GEPH_HUMAN [view entry] [view interactions] Low throughput yes yes
GBRB3_HUMAN [view entry] [view interactions] Low throughput yes no
ARHG9_HUMAN [view entry] [view interactions] Low throughput yes yes
NGEF_HUMAN [view entry] [view interactions] Low throughput yes yes
GRM5_HUMAN [view entry] [view interactions] Low throughput yes no
KCD12_HUMAN [view entry] [view interactions] Low throughput yes no
EGFR_HUMAN [view interactions] High throughput no no
MDM2_HUMAN [view interactions] High throughput no yes
CSK_HUMAN [view interactions] High throughput no yes
AT1A1_HUMAN [view entry] [view interactions] High throughput yes no
GBRA1_HUMAN [view entry] [view interactions] High throughput yes yes
GBRA2_HUMAN [view entry] [view interactions] High throughput yes no
GBRA3_HUMAN [view entry] [view interactions] High throughput yes yes
GBRA4_HUMAN [view entry] [view interactions] High throughput yes no
GBRA5_HUMAN [view entry] [view interactions] High throughput yes no
GBRB1_HUMAN [view entry] [view interactions] High throughput yes no
GBRB2_HUMAN [view entry] [view interactions] High throughput yes no
GABR2_HUMAN [view entry] [view interactions] Computational yes yes
NSF_HUMAN [view entry] [view interactions] Computational yes yes
GBRA6_HUMAN [view entry] [view interactions] Computational yes no
GBRAP_HUMAN [view interactions] Computational no no
DYN1_HUMAN [view entry] [view interactions] Computational yes yes