GBRA2_HUMAN
Evidence for PS localization
Functions
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed, PubMed). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed, PubMed). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer . The alpha2/beta2/gamma2 receptor exhibits synaptogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GBRA2_HUMAN |
|---|---|---|---|---|
| GO:0004890 | GABA-A receptor activity | 50.0000 | 5 | yes |
| GO:0005216 | monoatomic ion channel activity | 50.0000 | 4 | yes |
| GO:0005230 | extracellular ligand-gated monoatomic ion channel activity | 50.0000 | 6 | yes |
| GO:0005253 | monoatomic anion channel activity | 50.0000 | 5 | yes |
| GO:0005254 | chloride channel activity | 50.0000 | 6 | yes |
| GO:0008509 | monoatomic anion transmembrane transporter activity | 50.0000 | 4 | yes |
| GO:0015103 | inorganic anion transmembrane transporter activity | 50.0000 | 4 | yes |
| GO:0015108 | chloride transmembrane transporter activity | 50.0000 | 5 | yes |
| GO:0015267 | channel activity | 50.0000 | 4 | yes |
| GO:0015276 | ligand-gated monoatomic ion channel activity | 50.0000 | 5 | yes |
| GO:0016917 | GABA receptor activity | 50.0000 | 4 | yes |
| GO:0022824 | transmitter-gated monoatomic ion channel activity | 50.0000 | 5 | yes |
| GO:0022834 | ligand-gated channel activity | 50.0000 | 6 | yes |
| GO:0022835 | transmitter-gated channel activity | 50.0000 | 4 | yes |
| GO:0022836 | gated channel activity | 50.0000 | 5 | yes |
| GO:0022851 | GABA-gated chloride ion channel activity | 50.0000 | 6 | yes |
| GO:0099095 | ligand-gated monoatomic anion channel activity | 50.0000 | 6 | yes |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 45.0000 | 4 | yes |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 40.0000 | 5 | yes |
| GO:1904315 | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential | 40.0000 | 6 | yes |
| GO:0005237 | inhibitory extracellular ligand-gated monoatomic ion channel activity | 35.0000 | 7 | yes |
| GO:0008503 | benzodiazepine receptor activity | 25.0000 | 4 | yes |
| GO:0099507 | ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential | 20.0000 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GBRA2_HUMAN |
|---|---|---|---|---|
| GO:0099536 | synaptic signaling | 55.0000 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 55.0000 | 5 | yes |
| GO:0006811 | monoatomic ion transport | 55.0000 | 4 | yes |
| GO:0007268 | chemical synaptic transmission | 55.0000 | 7 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 55.0000 | 6 | yes |
| GO:1902476 | chloride transmembrane transport | 50.0000 | 5 | yes |
| GO:0006820 | monoatomic anion transport | 50.0000 | 5 | yes |
| GO:0006821 | chloride transport | 50.0000 | 5 | yes |
| GO:0007214 | gamma-aminobutyric acid signaling pathway | 50.0000 | 4 | yes |
| GO:0015698 | inorganic anion transport | 50.0000 | 4 | yes |
| GO:0022607 | cellular component assembly | 50.0000 | 4 | yes |
| GO:0098656 | monoatomic anion transmembrane transport | 50.0000 | 4 | yes |
| GO:0098661 | inorganic anion transmembrane transport | 50.0000 | 4 | yes |
| GO:0034330 | cell junction organization | 45.0000 | 4 | yes |
| GO:0051932 | synaptic transmission, GABAergic | 45.0000 | 8 | yes |
| GO:0010646 | regulation of cell communication | 40.0000 | 4 | no |
| GO:0050808 | synapse organization | 40.0000 | 5 | yes |
| GO:0071310 | cellular response to organic substance | 35.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 35.0000 | 4 | no |
| GO:0034329 | cell junction assembly | 35.0000 | 5 | yes |
| GO:0060078 | regulation of postsynaptic membrane potential | 35.0000 | 4 | yes |
| GO:1904862 | inhibitory synapse assembly | 30.0000 | 7 | yes |
| GO:0010243 | response to organonitrogen compound | 30.0000 | 4 | no |
| GO:0014070 | response to organic cyclic compound | 30.0000 | 4 | no |
| GO:0071407 | cellular response to organic cyclic compound | 30.0000 | 5 | no |
| GO:0071417 | cellular response to organonitrogen compound | 30.0000 | 4 | no |
| GO:1901699 | cellular response to nitrogen compound | 30.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 30.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 30.0000 | 4 | no |
| GO:0007416 | synapse assembly | 30.0000 | 6 | yes |
| GO:0031323 | regulation of cellular metabolic process | 25.0000 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 25.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 25.0000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.0000 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| UBQL1_HUMAN | [view interactions] | Low throughput | no | yes |
| GBRG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GEPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBRB3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ARHG9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NGEF_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRM5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KCD12_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| MDM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| CDKL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAOK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBRA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBRA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRA4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBRA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |