NGEF_HUMAN
Evidence for PS localization
Functions
Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NGEF_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 38.0952 | 4 | no |
| GO:0043168 | anion binding | 35.7143 | 4 | no |
| GO:0019901 | protein kinase binding | 33.3333 | 5 | no |
| GO:0000166 | nucleotide binding | 30.9524 | 4 | no |
| GO:0017076 | purine nucleotide binding | 30.9524 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 30.9524 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 30.9524 | 4 | no |
| GO:0043169 | cation binding | 28.5714 | 4 | no |
| GO:0046872 | metal ion binding | 26.1905 | 5 | no |
| GO:0005085 | guanyl-nucleotide exchange factor activity | 4.7619 | 5 | yes |
| GO:0030695 | GTPase regulator activity | 4.7619 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NGEF_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 64.2857 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 59.5238 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 59.5238 | 4 | no |
| GO:0010646 | regulation of cell communication | 54.7619 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 54.7619 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 52.3810 | 4 | no |
| GO:0009966 | regulation of signal transduction | 50.0000 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 47.6190 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 45.2381 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 40.4762 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 40.4762 | 5 | no |
| GO:0006996 | organelle organization | 38.0952 | 4 | no |
| GO:0022607 | cellular component assembly | 38.0952 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 38.0952 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 35.7143 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 35.7143 | 6 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 35.7143 | 5 | yes |
| GO:0031399 | regulation of protein modification process | 35.7143 | 6 | no |
| GO:0009889 | regulation of biosynthetic process | 35.7143 | 4 | no |
| GO:0010468 | regulation of gene expression | 35.7143 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 35.7143 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 35.7143 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 33.3333 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 33.3333 | 7 | no |
| GO:0019220 | regulation of phosphate metabolic process | 33.3333 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 33.3333 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 33.3333 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 33.3333 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 33.3333 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.9524 | 6 | no |
| GO:0051049 | regulation of transport | 30.9524 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 30.9524 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 30.9524 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 28.5714 | 5 | no |
| GO:0023056 | positive regulation of signaling | 28.5714 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 28.5714 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 28.5714 | 4 | no |
| GO:0051336 | regulation of hydrolase activity | 26.1905 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 26.1905 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 26.1905 | 7 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.1905 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 26.1905 | 4 | no |
| GO:0051050 | positive regulation of transport | 26.1905 | 4 | no |
| GO:0010975 | regulation of neuron projection development | 23.8095 | 7 | yes |
| GO:0050807 | regulation of synapse organization | 23.8095 | 5 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 23.8095 | 8 | no |
| GO:0007010 | cytoskeleton organization | 23.8095 | 5 | no |
| GO:0008104 | protein localization | 23.8095 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 23.8095 | 6 | no |
| GO:0042327 | positive regulation of phosphorylation | 23.8095 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 23.8095 | 7 | no |
| GO:0141124 | intracellular signaling cassette | 23.8095 | 4 | no |
| GO:0030334 | regulation of cell migration | 23.8095 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 23.8095 | 4 | no |
| GO:0043549 | regulation of kinase activity | 23.8095 | 5 | no |
| GO:0045859 | regulation of protein kinase activity | 23.8095 | 6 | no |
| GO:0051094 | positive regulation of developmental process | 23.8095 | 4 | no |
| GO:0051338 | regulation of transferase activity | 23.8095 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 23.8095 | 4 | no |
| GO:2000145 | regulation of cell motility | 23.8095 | 4 | no |
| GO:0033043 | regulation of organelle organization | 23.8095 | 5 | no |
| GO:0043066 | negative regulation of apoptotic process | 23.8095 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 23.8095 | 5 | no |
| GO:0030030 | cell projection organization | 21.4286 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 21.4286 | 5 | no |
| GO:0030335 | positive regulation of cell migration | 21.4286 | 6 | no |
| GO:0034330 | cell junction organization | 21.4286 | 4 | no |
| GO:0040017 | positive regulation of locomotion | 21.4286 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 21.4286 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 21.4286 | 6 | no |
| GO:0071310 | cellular response to organic substance | 21.4286 | 4 | no |
| GO:2000147 | positive regulation of cell motility | 21.4286 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 16.6667 | 5 | yes |
| GO:0099175 | regulation of postsynapse organization | 16.6667 | 6 | yes |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 14.2857 | 4 | yes |
| GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway | 14.2857 | 5 | yes |
| GO:0061001 | regulation of dendritic spine morphogenesis | 11.9048 | 5 | yes |
| GO:0043087 | regulation of GTPase activity | 9.5238 | 5 | yes |
| GO:0031345 | negative regulation of cell projection organization | 7.1429 | 6 | yes |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 7.1429 | 6 | yes |
| GO:0051093 | negative regulation of developmental process | 7.1429 | 4 | yes |
| GO:0060998 | regulation of dendritic spine development | 7.1429 | 4 | yes |
| GO:0010977 | negative regulation of neuron projection development | 4.7619 | 7 | yes |
| GO:0048013 | ephrin receptor signaling pathway | 4.7619 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| EPHA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CDC42_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RHOA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBRA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GBRB3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CG025_HUMAN | [view interactions] | High throughput | no | yes |
| CH033_HUMAN | [view interactions] | High throughput | no | yes |
| F118B_HUMAN | [view interactions] | High throughput | no | yes |
| RM44_HUMAN | [view interactions] | High throughput | no | yes |
| CPSF5_HUMAN | [view interactions] | High throughput | no | yes |
| TAF1D_HUMAN | [view interactions] | High throughput | no | yes |
| KPCI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTY_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KPCD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MRS2_HUMAN | [view interactions] | High throughput | no | no |
| ARP10_HUMAN | [view interactions] | High throughput | no | no |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| COPE_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3D_HUMAN | [view interactions] | High throughput | no | yes |
| IF4G2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUP35_HUMAN | [view interactions] | High throughput | no | yes |
| DEP1B_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| SH21A_HUMAN | [view interactions] | High throughput | no | no |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| GRN_HUMAN | [view interactions] | High throughput | no | no |
| GELS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WFS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF11_HUMAN | [view interactions] | High throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPG_HUMAN | [view interactions] | High throughput | no | yes |
| SMO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCOR_HUMAN | [view interactions] | High throughput | no | yes |
| TRI55_HUMAN | [view interactions] | High throughput | no | no |
| HCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| TFAP4_HUMAN | [view interactions] | High throughput | no | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| S12A8_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| MIC13_HUMAN | [view interactions] | High throughput | no | yes |
| CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| MIC19_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CIRBP_HUMAN | [view interactions] | High throughput | no | no |
| COPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPG1_HUMAN | [view interactions] | High throughput | no | yes |
| XPO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CSTF2_HUMAN | [view interactions] | High throughput | no | yes |
| CTND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DDX42_HUMAN | [view interactions] | High throughput | no | yes |
| DHE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LONM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AMRP_HUMAN | [view interactions] | High throughput | no | yes |
| NFL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOL7_HUMAN | [view interactions] | High throughput | no | yes |
| NOP58_HUMAN | [view interactions] | High throughput | no | yes |
| PPIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD3_HUMAN | [view interactions] | High throughput | no | yes |
| PSPC1_HUMAN | [view interactions] | High throughput | no | yes |
| RIF1_HUMAN | [view interactions] | High throughput | no | yes |
| RPR1A_HUMAN | [view interactions] | High throughput | no | yes |
| SERPH_HUMAN | [view interactions] | High throughput | no | no |
| SF3B6_HUMAN | [view interactions] | High throughput | no | yes |
| SF3B5_HUMAN | [view interactions] | High throughput | no | yes |
| SFXN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMC1A_HUMAN | [view interactions] | High throughput | no | yes |
| SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSRG_HUMAN | [view interactions] | High throughput | no | yes |
| STML2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOM22_HUMAN | [view interactions] | High throughput | no | yes |
| TPX2_HUMAN | [view interactions] | High throughput | no | yes |
| TBB4A_HUMAN | [view interactions] | High throughput | no | yes |
| XRN2_HUMAN | [view interactions] | High throughput | no | yes |
| ZN326_HUMAN | [view interactions] | High throughput | no | yes |
| LRRN1_HUMAN | [view interactions] | High throughput | no | yes |
| FEM1A_HUMAN | [view interactions] | High throughput | no | no |
| HCFC2_HUMAN | [view interactions] | High throughput | no | yes |
| HTSF1_HUMAN | [view interactions] | High throughput | no | yes |
| GORS1_HUMAN | [view interactions] | High throughput | no | yes |
| NEUA_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBP7_HUMAN | [view interactions] | High throughput | no | yes |
| FGD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LPXN_HUMAN | [view interactions] | High throughput | no | yes |
| RHG42_HUMAN | [view interactions] | High throughput | no | yes |
| ARHGJ_HUMAN | [view interactions] | High throughput | no | no |
| FCHO2_HUMAN | [view interactions] | High throughput | no | yes |
| PRIC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PDLI5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NUP43_HUMAN | [view interactions] | High throughput | no | yes |