Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NGEF_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NGEF_HUMAN
GO:0017076 purine nucleotide binding 44.0000 4 no
GO:0032555 purine ribonucleotide binding 44.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 44.0000 4 no
GO:0019900 kinase binding 40.0000 4 no
GO:0019901 protein kinase binding 36.0000 5 no
GO:0005524 ATP binding 30.0000 5 no
GO:0030554 adenyl nucleotide binding 30.0000 5 no
GO:0032559 adenyl ribonucleotide binding 30.0000 5 no
GO:0004712 protein serine/threonine/tyrosine kinase activity 24.0000 4 no
GO:0016301 kinase activity 24.0000 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 24.0000 4 no
GO:0046872 metal ion binding 24.0000 4 no
GO:0005085 guanyl-nucleotide exchange factor activity 4.0000 5 yes
GO:0030695 GTPase regulator activity 4.0000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NGEF_HUMAN
GO:0048522 positive regulation of cellular process 68.0000 4 no
GO:0051128 regulation of cellular component organization 60.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 60.0000 4 no
GO:0048523 negative regulation of cellular process 58.0000 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 58.0000 4 no
GO:0080090 regulation of primary metabolic process 58.0000 4 no
GO:0031323 regulation of cellular metabolic process 56.0000 4 no
GO:0010646 regulation of cell communication 52.0000 4 yes
GO:0009893 positive regulation of metabolic process 52.0000 4 no
GO:0009966 regulation of signal transduction 50.0000 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 46.0000 5 no
GO:0022603 regulation of anatomical structure morphogenesis 44.0000 4 yes
GO:0031325 positive regulation of cellular metabolic process 44.0000 5 no
GO:0051246 regulation of protein metabolic process 44.0000 5 no
GO:0031344 regulation of cell projection organization 42.0000 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 42.0000 6 yes
GO:1902531 regulation of intracellular signal transduction 42.0000 5 yes
GO:0051049 regulation of transport 42.0000 4 no
GO:0019220 regulation of phosphate metabolic process 40.0000 6 no
GO:0048584 positive regulation of response to stimulus 40.0000 4 no
GO:0051130 positive regulation of cellular component organization 40.0000 5 no
GO:0051174 regulation of phosphorus metabolic process 40.0000 5 no
GO:0022607 cellular component assembly 40.0000 4 no
GO:0006996 organelle organization 40.0000 4 no
GO:0031399 regulation of protein modification process 38.0000 6 no
GO:0042325 regulation of phosphorylation 38.0000 7 no
GO:0051247 positive regulation of protein metabolic process 38.0000 6 no
GO:0043085 positive regulation of catalytic activity 36.0000 4 yes
GO:0001932 regulation of protein phosphorylation 36.0000 7 no
GO:0010562 positive regulation of phosphorus metabolic process 36.0000 6 no
GO:0045937 positive regulation of phosphate metabolic process 36.0000 7 no
GO:0010468 regulation of gene expression 36.0000 5 no
GO:0010941 regulation of cell death 36.0000 4 no
GO:0009892 negative regulation of metabolic process 34.0000 4 no
GO:0042327 positive regulation of phosphorylation 34.0000 8 no
GO:0042981 regulation of apoptotic process 34.0000 6 no
GO:0043067 regulation of programmed cell death 34.0000 5 no
GO:0051336 regulation of hydrolase activity 32.0000 4 yes
GO:0006796 phosphate-containing compound metabolic process 32.0000 4 no
GO:0010647 positive regulation of cell communication 32.0000 5 no
GO:0023056 positive regulation of signaling 32.0000 4 no
GO:0031401 positive regulation of protein modification process 32.0000 7 no
GO:0036211 protein modification process 32.0000 4 no
GO:0043412 macromolecule modification 32.0000 4 no
GO:0001934 positive regulation of protein phosphorylation 30.0000 8 no
GO:0010605 negative regulation of macromolecule metabolic process 30.0000 5 no
GO:0030030 cell projection organization 30.0000 4 no
GO:0030155 regulation of cell adhesion 30.0000 4 no
GO:0043549 regulation of kinase activity 30.0000 5 no
GO:0051094 positive regulation of developmental process 30.0000 4 no
GO:0051338 regulation of transferase activity 30.0000 4 no
GO:0051050 positive regulation of transport 30.0000 4 no
GO:0044087 regulation of cellular component biogenesis 30.0000 4 no
GO:0033043 regulation of organelle organization 30.0000 5 no
GO:0010975 regulation of neuron projection development 28.0000 7 yes
GO:0009967 positive regulation of signal transduction 28.0000 5 no
GO:0016310 phosphorylation 28.0000 5 no
GO:0051240 positive regulation of multicellular organismal process 28.0000 4 no
GO:0120036 plasma membrane bounded cell projection organization 28.0000 5 no
GO:0002684 positive regulation of immune system process 28.0000 4 no
GO:0006468 protein phosphorylation 26.0000 5 no
GO:0031346 positive regulation of cell projection organization 26.0000 6 no
GO:0033674 positive regulation of kinase activity 26.0000 6 no
GO:0045859 regulation of protein kinase activity 26.0000 6 no
GO:0048585 negative regulation of response to stimulus 26.0000 4 no
GO:0051347 positive regulation of transferase activity 26.0000 5 no
GO:0071310 cellular response to organic substance 26.0000 4 no
GO:0080134 regulation of response to stress 26.0000 4 no
GO:0009889 regulation of biosynthetic process 26.0000 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 26.0000 5 no
GO:0031324 negative regulation of cellular metabolic process 26.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 26.0000 5 no
GO:0007010 cytoskeleton organization 26.0000 5 no
GO:0010942 positive regulation of cell death 26.0000 5 no
GO:0043068 positive regulation of programmed cell death 24.0000 6 no
GO:0032880 regulation of protein localization 24.0000 5 no
GO:0060341 regulation of cellular localization 24.0000 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 24.0000 4 yes
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 24.0000 5 yes
GO:0051129 negative regulation of cellular component organization 24.0000 5 yes
GO:0051345 positive regulation of hydrolase activity 24.0000 5 yes
GO:0010243 response to organonitrogen compound 24.0000 4 no
GO:0022604 regulation of cell morphogenesis 24.0000 5 no
GO:0030334 regulation of cell migration 24.0000 5 no
GO:0032101 regulation of response to external stimulus 24.0000 4 no
GO:0034330 cell junction organization 24.0000 4 no
GO:0045595 regulation of cell differentiation 24.0000 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 24.0000 5 no
GO:2000026 regulation of multicellular organismal development 24.0000 4 no
GO:2000145 regulation of cell motility 24.0000 4 no
GO:0043065 positive regulation of apoptotic process 24.0000 7 no
GO:0051493 regulation of cytoskeleton organization 22.0000 6 no
GO:0050776 regulation of immune response 22.0000 4 no
GO:0016192 vesicle-mediated transport 22.0000 4 no
GO:0030335 positive regulation of cell migration 22.0000 6 no
GO:0031175 neuron projection development 22.0000 6 no
GO:0040017 positive regulation of locomotion 22.0000 4 no
GO:0045597 positive regulation of cell differentiation 22.0000 5 no
GO:0051248 negative regulation of protein metabolic process 22.0000 6 no
GO:0060284 regulation of cell development 22.0000 5 no
GO:2000147 positive regulation of cell motility 22.0000 5 no
GO:0010556 regulation of macromolecule biosynthetic process 22.0000 5 no
GO:0060548 negative regulation of cell death 22.0000 5 no
GO:0032956 regulation of actin cytoskeleton organization 22.0000 5 no
GO:0032970 regulation of actin filament-based process 22.0000 4 no
GO:0050807 regulation of synapse organization 20.0000 5 yes
GO:0048013 ephrin receptor signaling pathway 16.0000 6 yes
GO:0099175 regulation of postsynapse organization 16.0000 6 yes
GO:0031345 negative regulation of cell projection organization 14.0000 6 yes
GO:0051093 negative regulation of developmental process 12.0000 4 yes
GO:0061001 regulation of dendritic spine morphogenesis 12.0000 5 yes
GO:0010977 negative regulation of neuron projection development 10.0000 7 yes
GO:0051056 regulation of small GTPase mediated signal transduction 10.0000 6 yes
GO:0043087 regulation of GTPase activity 8.0000 5 yes
GO:0060998 regulation of dendritic spine development 8.0000 4 yes
GO:0007399 nervous system development 4.0000 4 yes
GO:0043547 positive regulation of GTPase activity 4.0000 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in NGEF_HUMAN
DOID:10595 Charcot-Marie-Tooth disease 4.0000 6 no
DOID:440 neuromuscular disease 4.0000 5 no
DOID:574 peripheral nervous system disease 4.0000 3 no
DOID:870 neuropathy 4.0000 4 no
DOID:0050700 cardiomyopathy 4.0000 4 no
DOID:0060036 intrinsic cardiomyopathy 4.0000 5 no
DOID:114 heart disease 4.0000 3 no
DOID:2843 long QT syndrome 4.0000 6 no
DOID:0111962 combined immunodeficiency 4.0000 4 no
DOID:612 primary immunodeficiency disease 4.0000 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
EPHA4_HUMAN [view entry] [view interactions] Low throughput yes yes
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
CDC42_HUMAN [view entry] [view interactions] Low throughput yes yes
RHOA_HUMAN [view entry] [view interactions] Low throughput yes yes
GBRA2_HUMAN [view entry] [view interactions] Low throughput yes no
GBRB3_HUMAN [view entry] [view interactions] Low throughput yes no
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
CG025_HUMAN [view interactions] High throughput no yes
CH033_HUMAN [view interactions] High throughput no yes
F118B_HUMAN [view interactions] High throughput no yes
RM44_HUMAN [view interactions] High throughput no yes
CPSF5_HUMAN [view interactions] High throughput no yes
TAF1D_HUMAN [view interactions] High throughput no yes
MRS2_HUMAN [view interactions] High throughput no no
ARP10_HUMAN [view interactions] High throughput no no
KPCD_HUMAN [view entry] [view interactions] High throughput yes yes
ACTY_HUMAN [view entry] [view interactions] High throughput yes no
KPCI_HUMAN [view entry] [view interactions] High throughput yes yes
NUP35_HUMAN [view interactions] High throughput no yes
IF4G2_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3D_HUMAN [view interactions] High throughput no yes
COPE_HUMAN [view interactions] High throughput no yes
CLPP_HUMAN [view interactions] High throughput no yes
DEP1B_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC4_HUMAN [view interactions] High throughput no yes
SH21A_HUMAN [view interactions] High throughput no no
FGFR3_HUMAN [view interactions] High throughput no yes
GRN_HUMAN [view interactions] High throughput no no
GELS_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
WFS1_HUMAN [view entry] [view interactions] High throughput yes yes
RNF11_HUMAN [view interactions] High throughput no yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
ATPG_HUMAN [view interactions] High throughput no yes
SMO_HUMAN [view interactions] High throughput no yes
TRI55_HUMAN [view interactions] High throughput no no
HCK_HUMAN [view entry] [view interactions] High throughput yes no
TRI63_HUMAN [view interactions] High throughput no no
TFAP4_HUMAN [view interactions] High throughput no yes
WDTC1_HUMAN [view interactions] High throughput no yes
S12A8_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
MIC13_HUMAN [view interactions] High throughput no yes
CAND1_HUMAN [view entry] [view interactions] High throughput yes no
CDK9_HUMAN [view interactions] High throughput no yes
MIC19_HUMAN [view entry] [view interactions] High throughput yes yes
CIRBP_HUMAN [view interactions] High throughput no no
COPA_HUMAN [view entry] [view interactions] High throughput yes yes
COPG1_HUMAN [view interactions] High throughput no yes
XPO2_HUMAN [view entry] [view interactions] High throughput yes no
CSTF2_HUMAN [view interactions] High throughput no yes
CTND1_HUMAN [view entry] [view interactions] High throughput yes no
DDX42_HUMAN [view interactions] High throughput no yes
DHE3_HUMAN [view entry] [view interactions] High throughput yes yes
IMA1_HUMAN [view entry] [view interactions] High throughput yes yes
LONM_HUMAN [view entry] [view interactions] High throughput yes yes
AMRP_HUMAN [view interactions] High throughput no yes
NFL_HUMAN [view entry] [view interactions] High throughput yes yes
NOL7_HUMAN [view interactions] High throughput no yes
NOP58_HUMAN [view interactions] High throughput no yes
PPIB_HUMAN [view entry] [view interactions] High throughput yes yes
PSMD3_HUMAN [view interactions] High throughput no yes
PSPC1_HUMAN [view interactions] High throughput no yes
RIF1_HUMAN [view interactions] High throughput no yes
RPR1A_HUMAN [view interactions] High throughput no yes
SERPH_HUMAN [view interactions] High throughput no no
SF3B6_HUMAN [view interactions] High throughput no yes
SF3B5_HUMAN [view interactions] High throughput no yes
SFXN1_HUMAN [view entry] [view interactions] High throughput yes yes
SMC1A_HUMAN [view interactions] High throughput no yes
SSBP_HUMAN [view entry] [view interactions] High throughput yes yes
SSRG_HUMAN [view interactions] High throughput no yes
STML2_HUMAN [view entry] [view interactions] High throughput yes yes
TOM22_HUMAN [view interactions] High throughput no yes
TPX2_HUMAN [view interactions] High throughput no yes
TBB4A_HUMAN [view interactions] High throughput no yes
XRN2_HUMAN [view interactions] High throughput no yes
ZN326_HUMAN [view interactions] High throughput no yes
LRRN1_HUMAN [view interactions] High throughput no yes
FEM1A_HUMAN [view interactions] High throughput no no
HCFC2_HUMAN [view interactions] High throughput no yes
HTSF1_HUMAN [view interactions] High throughput no yes
GORS1_HUMAN [view interactions] High throughput no yes
NEUA_HUMAN [view interactions] High throughput no yes
FGD4_HUMAN [view entry] [view interactions] High throughput yes yes
LPXN_HUMAN [view interactions] High throughput no yes
RHG42_HUMAN [view interactions] High throughput no yes
ARHGJ_HUMAN [view interactions] High throughput no no
FCHO2_HUMAN [view interactions] High throughput no yes
PRIC2_HUMAN [view entry] [view interactions] High throughput yes no
PDLI5_HUMAN [view entry] [view interactions] High throughput yes no
RAC3_HUMAN [view entry] [view interactions] Computational yes no
FYN_HUMAN [view entry] [view interactions] Computational yes no
EPHA7_HUMAN [view entry] [view interactions] Computational yes no
RAC2_HUMAN [view entry] [view interactions] Computational yes yes
YES_HUMAN [view entry] [view interactions] Computational yes yes
EPHB4_HUMAN [view interactions] Computational no yes
EFNA1_HUMAN [view interactions] Computational no no
LYN_HUMAN [view entry] [view interactions] Computational yes no
BLK_HUMAN [view interactions] Computational no no
EPHA3_HUMAN [view interactions] Computational no yes
EPHA2_HUMAN [view interactions] Computational no no
EPHA8_HUMAN [view interactions] Computational no no
FGR_HUMAN [view interactions] Computational no no
LCK_HUMAN [view entry] [view interactions] Computational yes no
SRC_HUMAN [view entry] [view interactions] Computational yes no
EPHB3_HUMAN [view interactions] Computational no yes
EPHA1_HUMAN [view interactions] Computational no yes
EPHB1_HUMAN [view interactions] Computational no no
EPHB2_HUMAN [view entry] [view interactions] Computational yes yes