HCK_HUMAN
Evidence for PS localization
Functions
Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI000198 | LIG_SH3_4 | LIG | 248 | 255 | - |
| ELMI002314 | MOD_NMyristoyl | MOD | 1 | 7 | - |
| ELMI000136 | MOD_TYR_CSK | MOD | 518 | 526 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in HCK_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 48.2143 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 46.4286 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 46.4286 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 44.6429 | 5 | yes |
| GO:0005524 | ATP binding | 42.8571 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 42.8571 | 5 | yes |
| GO:0019900 | kinase binding | 28.5714 | 4 | no |
| GO:0019901 | protein kinase binding | 28.5714 | 5 | no |
| GO:0003723 | RNA binding | 26.7857 | 4 | no |
| GO:0016301 | kinase activity | 25.0000 | 4 | yes |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | 23.2143 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 23.2143 | 4 | yes |
| GO:0031625 | ubiquitin protein ligase binding | 23.2143 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 23.2143 | 4 | no |
| GO:0045296 | cadherin binding | 21.4286 | 4 | no |
| GO:0004713 | protein tyrosine kinase activity | 19.6429 | 4 | yes |
| GO:0004715 | non-membrane spanning protein tyrosine kinase activity | 14.2857 | 5 | yes |
| GO:0001784 | phosphotyrosine residue binding | 12.5000 | 5 | yes |
| GO:0045309 | protein phosphorylated amino acid binding | 12.5000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in HCK_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 75.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 73.2143 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 69.6429 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 67.8571 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 66.0714 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 64.2857 | 4 | yes |
| GO:0010646 | regulation of cell communication | 60.7143 | 4 | no |
| GO:0010468 | regulation of gene expression | 58.9286 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 57.1429 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 55.3571 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 53.5714 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 53.5714 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 53.5714 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 50.0000 | 4 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 50.0000 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 48.2143 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 44.6429 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 44.6429 | 5 | yes |
| GO:0010941 | regulation of cell death | 44.6429 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 44.6429 | 6 | yes |
| GO:0043067 | regulation of programmed cell death | 44.6429 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 44.6429 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 42.8571 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 42.8571 | 5 | yes |
| GO:0071310 | cellular response to organic substance | 42.8571 | 4 | no |
| GO:0031399 | regulation of protein modification process | 42.8571 | 6 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 41.0714 | 4 | yes |
| GO:0080134 | regulation of response to stress | 41.0714 | 4 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 41.0714 | 6 | no |
| GO:0051049 | regulation of transport | 39.2857 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 39.2857 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 37.5000 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 37.5000 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 37.5000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 37.5000 | 4 | no |
| GO:0036211 | protein modification process | 35.7143 | 4 | yes |
| GO:0043412 | macromolecule modification | 35.7143 | 4 | yes |
| GO:0051252 | regulation of RNA metabolic process | 35.7143 | 5 | yes |
| GO:0022607 | cellular component assembly | 35.7143 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 35.7143 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 35.7143 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 35.7143 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 35.7143 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 35.7143 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 33.9286 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 33.9286 | 4 | yes |
| GO:0048585 | negative regulation of response to stimulus | 33.9286 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 33.9286 | 5 | yes |
| GO:0060548 | negative regulation of cell death | 33.9286 | 5 | yes |
| GO:0001932 | regulation of protein phosphorylation | 33.9286 | 7 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 33.9286 | 5 | no |
| GO:0051336 | regulation of hydrolase activity | 33.9286 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 33.9286 | 6 | no |
| GO:0006355 | regulation of DNA-templated transcription | 32.1429 | 6 | yes |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 32.1429 | 4 | yes |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 32.1429 | 5 | yes |
| GO:0033043 | regulation of organelle organization | 32.1429 | 5 | yes |
| GO:0043066 | negative regulation of apoptotic process | 32.1429 | 7 | yes |
| GO:0043069 | negative regulation of programmed cell death | 32.1429 | 6 | yes |
| GO:0050776 | regulation of immune response | 32.1429 | 4 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 32.1429 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 32.1429 | 6 | yes |
| GO:2000145 | regulation of cell motility | 32.1429 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 32.1429 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 30.3571 | 4 | yes |
| GO:0030334 | regulation of cell migration | 30.3571 | 5 | no |
| GO:0010628 | positive regulation of gene expression | 30.3571 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 30.3571 | 7 | no |
| GO:0045595 | regulation of cell differentiation | 30.3571 | 4 | no |
| GO:0016310 | phosphorylation | 28.5714 | 5 | yes |
| GO:0032101 | regulation of response to external stimulus | 28.5714 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 28.5714 | 4 | no |
| GO:0006996 | organelle organization | 28.5714 | 4 | no |
| GO:0002684 | positive regulation of immune system process | 26.7857 | 4 | yes |
| GO:0006468 | protein phosphorylation | 26.7857 | 5 | yes |
| GO:0051050 | positive regulation of transport | 26.7857 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 26.7857 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 26.7857 | 4 | no |
| GO:0008104 | protein localization | 26.7857 | 4 | no |
| GO:0071702 | organic substance transport | 26.7857 | 4 | no |
| GO:0071705 | nitrogen compound transport | 26.7857 | 4 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 26.7857 | 8 | no |
| GO:0009894 | regulation of catabolic process | 26.7857 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 26.7857 | 6 | no |
| GO:0042327 | positive regulation of phosphorylation | 26.7857 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 26.7857 | 7 | no |
| GO:0030030 | cell projection organization | 26.7857 | 4 | no |
| GO:0051345 | positive regulation of hydrolase activity | 26.7857 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 26.7857 | 5 | no |
| GO:0023057 | negative regulation of signaling | 26.7857 | 4 | no |
| GO:0032880 | regulation of protein localization | 26.7857 | 5 | no |
| GO:0060341 | regulation of cellular localization | 26.7857 | 4 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 26.7857 | 6 | no |
| GO:0051338 | regulation of transferase activity | 26.7857 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 25.0000 | 4 | yes |
| GO:0051726 | regulation of cell cycle | 25.0000 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 25.0000 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.0000 | 6 | no |
| GO:0030155 | regulation of cell adhesion | 25.0000 | 4 | no |
| GO:0043549 | regulation of kinase activity | 25.0000 | 5 | no |
| GO:0014070 | response to organic cyclic compound | 25.0000 | 4 | no |
| GO:0008284 | positive regulation of cell population proliferation | 23.2143 | 5 | yes |
| GO:0018193 | peptidyl-amino acid modification | 23.2143 | 5 | yes |
| GO:0030335 | positive regulation of cell migration | 23.2143 | 6 | no |
| GO:0040017 | positive regulation of locomotion | 23.2143 | 4 | no |
| GO:2000147 | positive regulation of cell motility | 23.2143 | 5 | no |
| GO:0043933 | protein-containing complex organization | 23.2143 | 4 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 23.2143 | 6 | no |
| GO:0031344 | regulation of cell projection organization | 23.2143 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 23.2143 | 6 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 23.2143 | 6 | no |
| GO:0009968 | negative regulation of signal transduction | 23.2143 | 5 | no |
| GO:0001817 | regulation of cytokine production | 23.2143 | 4 | no |
| GO:0045859 | regulation of protein kinase activity | 23.2143 | 6 | no |
| GO:0030162 | regulation of proteolysis | 23.2143 | 6 | no |
| GO:0043254 | regulation of protein-containing complex assembly | 21.4286 | 5 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 21.4286 | 5 | yes |
| GO:0015031 | protein transport | 21.4286 | 4 | no |
| GO:0031329 | regulation of cellular catabolic process | 21.4286 | 5 | no |
| GO:0051093 | negative regulation of developmental process | 21.4286 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 21.4286 | 5 | no |
| GO:0051254 | positive regulation of RNA metabolic process | 21.4286 | 6 | no |
| GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 19.6429 | 4 | yes |
| GO:0010638 | positive regulation of organelle organization | 19.6429 | 6 | yes |
| GO:0018108 | peptidyl-tyrosine phosphorylation | 19.6429 | 6 | yes |
| GO:0018212 | peptidyl-tyrosine modification | 19.6429 | 6 | yes |
| GO:0031347 | regulation of defense response | 19.6429 | 5 | yes |
| GO:0050778 | positive regulation of immune response | 19.6429 | 5 | yes |
| GO:0002429 | immune response-activating cell surface receptor signaling pathway | 17.8571 | 4 | yes |
| GO:0032103 | positive regulation of response to external stimulus | 17.8571 | 5 | yes |
| GO:0046777 | protein autophosphorylation | 16.0714 | 6 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 16.0714 | 6 | yes |
| GO:1902115 | regulation of organelle assembly | 16.0714 | 5 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 16.0714 | 5 | yes |
| GO:0002683 | negative regulation of immune system process | 14.2857 | 4 | yes |
| GO:0002831 | regulation of response to biotic stimulus | 14.2857 | 4 | yes |
| GO:0007229 | integrin-mediated signaling pathway | 14.2857 | 4 | yes |
| GO:0022604 | regulation of cell morphogenesis | 14.2857 | 5 | yes |
| GO:0031334 | positive regulation of protein-containing complex assembly | 14.2857 | 6 | yes |
| GO:0038093 | Fc receptor signaling pathway | 14.2857 | 5 | yes |
| GO:0045088 | regulation of innate immune response | 14.2857 | 5 | yes |
| GO:0031349 | positive regulation of defense response | 12.5000 | 5 | yes |
| GO:0032102 | negative regulation of response to external stimulus | 12.5000 | 5 | yes |
| GO:0032271 | regulation of protein polymerization | 12.5000 | 6 | yes |
| GO:0050727 | regulation of inflammatory response | 12.5000 | 5 | yes |
| GO:1902905 | positive regulation of supramolecular fiber organization | 12.5000 | 6 | yes |
| GO:0002431 | Fc receptor mediated stimulatory signaling pathway | 10.7143 | 5 | yes |
| GO:0002833 | positive regulation of response to biotic stimulus | 10.7143 | 5 | yes |
| GO:0019221 | cytokine-mediated signaling pathway | 10.7143 | 4 | yes |
| GO:0031348 | negative regulation of defense response | 10.7143 | 5 | yes |
| GO:0032273 | positive regulation of protein polymerization | 10.7143 | 7 | yes |
| GO:0032956 | regulation of actin cytoskeleton organization | 10.7143 | 5 | yes |
| GO:0032970 | regulation of actin filament-based process | 10.7143 | 4 | yes |
| GO:0038094 | Fc-gamma receptor signaling pathway | 10.7143 | 6 | yes |
| GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | 10.7143 | 4 | yes |
| GO:0045089 | positive regulation of innate immune response | 10.7143 | 6 | yes |
| GO:0050728 | negative regulation of inflammatory response | 10.7143 | 6 | yes |
| GO:0050777 | negative regulation of immune response | 10.7143 | 5 | yes |
| GO:0051495 | positive regulation of cytoskeleton organization | 10.7143 | 7 | yes |
| GO:0002758 | innate immune response-activating signal transduction | 8.9286 | 4 | yes |
| GO:0002861 | regulation of inflammatory response to antigenic stimulus | 8.9286 | 5 | yes |
| GO:0002862 | negative regulation of inflammatory response to antigenic stimulus | 8.9286 | 6 | yes |
| GO:0046903 | secretion | 8.9286 | 4 | yes |
| GO:0110053 | regulation of actin filament organization | 8.9286 | 6 | yes |
| GO:0006887 | exocytosis | 7.1429 | 4 | yes |
| GO:0006954 | inflammatory response | 7.1429 | 4 | yes |
| GO:0008360 | regulation of cell shape | 7.1429 | 6 | yes |
| GO:0032535 | regulation of cellular component size | 7.1429 | 4 | yes |
| GO:0050764 | regulation of phagocytosis | 7.1429 | 5 | yes |
| GO:0071801 | regulation of podosome assembly | 7.1429 | 6 | yes |
| GO:2000249 | regulation of actin cytoskeleton reorganization | 7.1429 | 6 | yes |
| GO:0008064 | regulation of actin polymerization or depolymerization | 5.3571 | 6 | yes |
| GO:0030832 | regulation of actin filament length | 5.3571 | 5 | yes |
| GO:0030833 | regulation of actin filament polymerization | 5.3571 | 7 | yes |
| GO:0030838 | positive regulation of actin filament polymerization | 5.3571 | 7 | yes |
| GO:0031663 | lipopolysaccharide-mediated signaling pathway | 5.3571 | 4 | yes |
| GO:0045055 | regulated exocytosis | 5.3571 | 5 | yes |
| GO:2000251 | positive regulation of actin cytoskeleton reorganization | 5.3571 | 7 | yes |
| GO:0007498 | mesoderm development | 3.5714 | 4 | yes |
| GO:0045728 | respiratory burst after phagocytosis | 3.5714 | 4 | yes |
| GO:0060333 | interferon-gamma-mediated signaling pathway | 3.5714 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in HCK_HUMAN |
|---|---|---|---|---|
| DOID:10595 | Charcot-Marie-Tooth disease | 5.3571 | 6 | no |
| DOID:440 | neuromuscular disease | 5.3571 | 5 | no |
| DOID:574 | peripheral nervous system disease | 5.3571 | 3 | no |
| DOID:870 | neuropathy | 5.3571 | 4 | no |
| DOID:1289 | neurodegenerative disease | 3.5714 | 4 | no |
| DOID:231 | motor neuron disease | 3.5714 | 5 | no |
| DOID:331 | central nervous system disease | 3.5714 | 3 | no |
| DOID:612 | primary immunodeficiency disease | 3.5714 | 3 | no |
| DOID:0050539 | Charcot-Marie-Tooth disease type 2 | 3.5714 | 7 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CBLB_HUMAN | [view interactions] | Low throughput | no | yes |
| RUFY1_HUMAN | [view interactions] | Low throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| BTK_HUMAN | [view interactions] | Low throughput | no | no |
| ADA22_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ITB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DIAP1_HUMAN | [view interactions] | Low throughput | no | yes |
| LOX5_HUMAN | [view interactions] | Low throughput | no | no |
| SPR2A_HUMAN | [view interactions] | Low throughput | no | no |
| RPGF1_HUMAN | [view interactions] | Low throughput | no | yes |
| BCR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CBL_HUMAN | [view interactions] | Low throughput | no | yes |
| SKAP2_HUMAN | [view interactions] | Low throughput | no | no |
| PECA1_HUMAN | [view interactions] | Low throughput | no | no |
| CCR3_HUMAN | [view interactions] | Low throughput | no | yes |
| CSF3R_HUMAN | [view interactions] | Low throughput | no | yes |
| CHSTF_HUMAN | [view interactions] | Low throughput | no | yes |
| IL6RB_HUMAN | [view interactions] | Low throughput | no | no |
| TRPV4_HUMAN | [view interactions] | Low throughput | no | yes |
| RASA3_HUMAN | [view interactions] | Low throughput | no | yes |
| RASA1_HUMAN | [view interactions] | Low throughput | no | yes |
| FCGR1_HUMAN | [view interactions] | Low throughput | no | no |
| DVL2_HUMAN | [view interactions] | Low throughput | no | yes |
| P73_HUMAN | [view interactions] | Low throughput | no | no |
| FLT3_HUMAN | [view interactions] | Low throughput | no | no |
| HCK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| U119A_HUMAN | [view interactions] | Low throughput | no | no |
| BCAR1_HUMAN | [view interactions] | Low throughput | no | yes |
| RL10_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CBP_HUMAN | [view interactions] | Low throughput | no | yes |
| ACK1_HUMAN | [view interactions] | Low throughput | no | yes |
| STAT3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MDM2_HUMAN | [view interactions] | Low throughput | no | yes |
| GPVI_HUMAN | [view interactions] | Low throughput | no | no |
| ADA15_HUMAN | [view interactions] | Low throughput | no | yes |
| KHDR1_HUMAN | [view interactions] | Low throughput | no | yes |
| PDC6I_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NAL12_HUMAN | [view interactions] | Low throughput | no | yes |
| WASP_HUMAN | [view interactions] | Low throughput | no | yes |
| ABL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| WIPF1_HUMAN | [view interactions] | Low throughput | no | no |
| ELMO1_HUMAN | [view interactions] | Low throughput | no | no |
| SOS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SH3K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EVL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD2AP_HUMAN | [view interactions] | High throughput | no | no |
| 3BP1_HUMAN | [view interactions] | High throughput | no | no |
| TS101_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDCP_HUMAN | [view interactions] | High throughput | no | yes |
| P85B_HUMAN | [view interactions] | High throughput | no | yes |
| LCP2_HUMAN | [view interactions] | High throughput | no | yes |
| P85A_HUMAN | [view interactions] | High throughput | no | yes |
| NUCL_HUMAN | [view interactions] | High throughput | no | yes |
| SF3B3_HUMAN | [view interactions] | High throughput | no | yes |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRP4B_HUMAN | [view interactions] | High throughput | no | yes |
| PTN11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSKP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IRAK2_HUMAN | [view interactions] | High throughput | no | yes |
| RT02_HUMAN | [view interactions] | High throughput | no | no |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ADCK2_HUMAN | [view interactions] | High throughput | no | yes |
| STK33_HUMAN | [view interactions] | High throughput | no | no |
| CD177_HUMAN | [view interactions] | High throughput | no | no |
| ABL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WNT2_HUMAN | [view interactions] | High throughput | no | no |
| KR109_HUMAN | [view interactions] | High throughput | no | no |
| MTUS2_HUMAN | [view interactions] | High throughput | no | yes |
| K1C40_HUMAN | [view interactions] | High throughput | no | no |
| NT2NA_HUMAN | [view interactions] | High throughput | no | no |
| GOPC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M4K5_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| ERBB3_HUMAN | [view interactions] | High throughput | no | yes |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| GAB1_HUMAN | [view interactions] | High throughput | no | yes |
| KIT_HUMAN | [view interactions] | High throughput | no | no |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PK3CB_HUMAN | [view interactions] | High throughput | no | yes |
| PLCG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VGFR1_HUMAN | [view interactions] | High throughput | no | no |
| CRKL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NGEF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P55G_HUMAN | [view interactions] | High throughput | no | yes |
| FRS3_HUMAN | [view interactions] | High throughput | no | no |
| LTMD1_HUMAN | [view interactions] | High throughput | no | no |
| OLIG1_HUMAN | [view interactions] | High throughput | no | no |
| FAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRB14_HUMAN | [view interactions] | High throughput | no | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRIM1_HUMAN | [view interactions] | High throughput | no | no |
| TRIP6_HUMAN | [view interactions] | High throughput | no | yes |
| K1H1_HUMAN | [view interactions] | High throughput | no | no |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| MK_HUMAN | [view interactions] | High throughput | no | no |
| FHL5_HUMAN | [view interactions] | High throughput | no | no |
| TOX2_HUMAN | [view interactions] | High throughput | no | no |
| KRT36_HUMAN | [view interactions] | High throughput | no | no |
| KRT34_HUMAN | [view interactions] | High throughput | no | no |
| RBPMS_HUMAN | [view interactions] | High throughput | no | no |
| HSF2B_HUMAN | [view interactions] | High throughput | no | yes |
| SH2B2_HUMAN | [view interactions] | High throughput | no | no |
| TEKT4_HUMAN | [view interactions] | High throughput | no | no |
| AP4AT_HUMAN | [view interactions] | High throughput | no | no |
| NEUFC_HUMAN | [view interactions] | High throughput | no | yes |
| CC88B_HUMAN | [view interactions] | High throughput | no | no |
| PNMA1_HUMAN | [view interactions] | High throughput | no | yes |
| MKRN3_HUMAN | [view interactions] | High throughput | no | yes |
| ZSCA4_HUMAN | [view interactions] | High throughput | no | no |
| CTG1B_HUMAN | [view interactions] | High throughput | no | no |
| KR108_HUMAN | [view interactions] | High throughput | no | no |
| KRA11_HUMAN | [view interactions] | High throughput | no | no |
| PKHG4_HUMAN | [view interactions] | High throughput | no | no |
| INCA1_HUMAN | [view interactions] | High throughput | no | no |
| KRT35_HUMAN | [view interactions] | High throughput | no | no |
| CRTP1_HUMAN | [view interactions] | High throughput | no | yes |
| BPIA1_HUMAN | [view interactions] | High throughput | no | no |
| KPRP_HUMAN | [view interactions] | High throughput | no | no |
| TRI27_HUMAN | [view interactions] | High throughput | no | yes |
| KRA31_HUMAN | [view interactions] | High throughput | no | no |
| KRA13_HUMAN | [view interactions] | High throughput | no | no |
| KR107_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| CA074_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EPHA2_HUMAN | [view interactions] | High throughput | no | no |
| PNMT_HUMAN | [view interactions] | High throughput | no | no |
| DOK1_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ERBB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MBP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DOK2_HUMAN | [view interactions] | High throughput | no | no |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| PAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TNFL6_HUMAN | [view interactions] | High throughput | no | yes |
| ADA12_HUMAN | [view interactions] | High throughput | no | no |
| ADA19_HUMAN | [view interactions] | High throughput | no | no |
| MED28_HUMAN | [view interactions] | High throughput | no | yes |
| TMG4_HUMAN | [view interactions] | High throughput | no | yes |
| FHL2_HUMAN | [view interactions] | High throughput | no | yes |
| RBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPRB_HUMAN | [view interactions] | High throughput | no | yes |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TXD12_HUMAN | [view interactions] | High throughput | no | no |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPC_HUMAN | [view interactions] | High throughput | no | yes |
| HNRC1_HUMAN | [view interactions] | High throughput | no | no |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H90B3_HUMAN | [view interactions] | High throughput | no | no |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRPS2_HUMAN | [view interactions] | High throughput | no | no |
| IMDH2_HUMAN | [view interactions] | High throughput | no | yes |
| HSP76_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AKA12_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KPRA_HUMAN | [view interactions] | High throughput | no | no |
| CHD4_HUMAN | [view interactions] | High throughput | no | yes |
| CHD3_HUMAN | [view interactions] | High throughput | no | yes |
| CHD5_HUMAN | [view interactions] | High throughput | no | no |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| H90B2_HUMAN | [view interactions] | High throughput | no | no |
| PGAM5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NS1BP_HUMAN | [view interactions] | High throughput | no | yes |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MAGB2_HUMAN | [view interactions] | High throughput | no | no |
| RL22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL37_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DPP2_HUMAN | [view interactions] | High throughput | no | yes |
| DYN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHIP1_HUMAN | [view interactions] | High throughput | no | no |