HCK_HUMAN
Evidence for PS localization
Functions
Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI000198 | LIG_SH3_4 | LIG | 248 | 255 | - |
| ELMI002314 | MOD_NMyristoyl | MOD | 1 | 7 | - |
| ELMI000136 | MOD_TYR_CSK | MOD | 518 | 526 | - |
| ELMI000198 | LIG_SH3_4 | LIG | 248 | 255 | - |
| ELMI002314 | MOD_NMyristoyl | MOD | 1 | 7 | - |
| ELMI000136 | MOD_TYR_CSK | MOD | 518 | 526 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in HCK_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 47.5410 | 4 | yes |
| GO:0000166 | nucleotide binding | 45.9016 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 45.9016 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 45.9016 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 45.9016 | 4 | yes |
| GO:0005524 | ATP binding | 42.6230 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 42.6230 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 42.6230 | 5 | yes |
| GO:0019900 | kinase binding | 27.8689 | 4 | no |
| GO:0019901 | protein kinase binding | 27.8689 | 5 | no |
| GO:0016301 | kinase activity | 26.2295 | 4 | yes |
| GO:0003723 | RNA binding | 26.2295 | 4 | no |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 24.5902 | 4 | yes |
| GO:0031625 | ubiquitin protein ligase binding | 24.5902 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 24.5902 | 4 | no |
| GO:0004713 | protein tyrosine kinase activity | 21.3115 | 4 | yes |
| GO:0043169 | cation binding | 21.3115 | 4 | no |
| GO:0046872 | metal ion binding | 21.3115 | 5 | no |
| GO:0004715 | non-membrane spanning protein tyrosine kinase activity | 16.3934 | 5 | yes |
| GO:0001784 | phosphotyrosine residue binding | 14.7541 | 5 | yes |
| GO:0045309 | protein phosphorylated amino acid binding | 14.7541 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in HCK_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 78.6885 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 70.4918 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 70.4918 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 67.2131 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 67.2131 | 4 | yes |
| GO:0010646 | regulation of cell communication | 57.3770 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 55.7377 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 55.7377 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 55.7377 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 55.7377 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 55.7377 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 55.7377 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 54.0984 | 5 | no |
| GO:0010468 | regulation of gene expression | 54.0984 | 6 | yes |
| GO:0009966 | regulation of signal transduction | 52.4590 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 50.8197 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 47.5410 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 45.9016 | 5 | yes |
| GO:0043067 | regulation of programmed cell death | 45.9016 | 4 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 44.2623 | 6 | no |
| GO:0031399 | regulation of protein modification process | 42.6230 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 40.9836 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 40.9836 | 5 | yes |
| GO:0042127 | regulation of cell population proliferation | 40.9836 | 4 | yes |
| GO:0080134 | regulation of response to stress | 39.3443 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 39.3443 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 39.3443 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 39.3443 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 39.3443 | 6 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 39.3443 | 4 | yes |
| GO:0051049 | regulation of transport | 37.7049 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 37.7049 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 36.0656 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 36.0656 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 36.0656 | 5 | no |
| GO:0022607 | cellular component assembly | 36.0656 | 4 | no |
| GO:0002684 | positive regulation of immune system process | 36.0656 | 4 | yes |
| GO:0048585 | negative regulation of response to stimulus | 34.4262 | 4 | yes |
| GO:0051252 | regulation of RNA metabolic process | 34.4262 | 5 | yes |
| GO:0001932 | regulation of protein phosphorylation | 34.4262 | 7 | no |
| GO:0042325 | regulation of phosphorylation | 34.4262 | 7 | no |
| GO:0043412 | macromolecule modification | 32.7869 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 32.7869 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 32.7869 | 5 | no |
| GO:0023056 | positive regulation of signaling | 32.7869 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 32.7869 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 32.7869 | 7 | no |
| GO:0008104 | protein localization | 32.7869 | 4 | no |
| GO:0032101 | regulation of response to external stimulus | 32.7869 | 4 | yes |
| GO:0036211 | protein modification process | 32.7869 | 4 | yes |
| GO:0043066 | negative regulation of apoptotic process | 32.7869 | 6 | yes |
| GO:0043069 | negative regulation of programmed cell death | 32.7869 | 5 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 31.1475 | 6 | yes |
| GO:0030334 | regulation of cell migration | 31.1475 | 5 | no |
| GO:2000145 | regulation of cell motility | 31.1475 | 4 | no |
| GO:0006996 | organelle organization | 31.1475 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 31.1475 | 7 | yes |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 31.1475 | 4 | yes |
| GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway | 31.1475 | 5 | yes |
| GO:0016310 | phosphorylation | 31.1475 | 5 | yes |
| GO:0050776 | regulation of immune response | 29.5082 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 29.5082 | 5 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 29.5082 | 8 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 29.5082 | 6 | no |
| GO:0042327 | positive regulation of phosphorylation | 29.5082 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 29.5082 | 7 | no |
| GO:0071310 | cellular response to organic substance | 29.5082 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 27.8689 | 4 | yes |
| GO:0045595 | regulation of cell differentiation | 27.8689 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 27.8689 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 27.8689 | 4 | no |
| GO:0009894 | regulation of catabolic process | 27.8689 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 27.8689 | 7 | no |
| GO:0050778 | positive regulation of immune response | 26.2295 | 5 | yes |
| GO:0030155 | regulation of cell adhesion | 26.2295 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 26.2295 | 4 | no |
| GO:0071702 | organic substance transport | 26.2295 | 4 | no |
| GO:0071705 | nitrogen compound transport | 26.2295 | 4 | no |
| GO:0043933 | protein-containing complex organization | 26.2295 | 4 | no |
| GO:0008284 | positive regulation of cell population proliferation | 26.2295 | 5 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 26.2295 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 26.2295 | 5 | yes |
| GO:0030335 | positive regulation of cell migration | 24.5902 | 6 | no |
| GO:0040017 | positive regulation of locomotion | 24.5902 | 4 | no |
| GO:0051336 | regulation of hydrolase activity | 24.5902 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 24.5902 | 6 | no |
| GO:2000147 | positive regulation of cell motility | 24.5902 | 5 | no |
| GO:0009890 | negative regulation of biosynthetic process | 24.5902 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 24.5902 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 24.5902 | 6 | no |
| GO:0032880 | regulation of protein localization | 24.5902 | 5 | no |
| GO:0060341 | regulation of cellular localization | 24.5902 | 4 | no |
| GO:0031347 | regulation of defense response | 24.5902 | 5 | yes |
| GO:0010648 | negative regulation of cell communication | 22.9508 | 5 | no |
| GO:0023057 | negative regulation of signaling | 22.9508 | 4 | no |
| GO:0051338 | regulation of transferase activity | 22.9508 | 4 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 22.9508 | 5 | no |
| GO:0006468 | protein phosphorylation | 22.9508 | 5 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 21.3115 | 4 | yes |
| GO:0001817 | regulation of cytokine production | 21.3115 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 21.3115 | 5 | no |
| GO:0030030 | cell projection organization | 21.3115 | 4 | no |
| GO:0030162 | regulation of proteolysis | 21.3115 | 6 | no |
| GO:0043549 | regulation of kinase activity | 21.3115 | 5 | no |
| GO:0045859 | regulation of protein kinase activity | 21.3115 | 6 | no |
| GO:0051248 | negative regulation of protein metabolic process | 21.3115 | 6 | no |
| GO:0015031 | protein transport | 21.3115 | 4 | no |
| GO:0051726 | regulation of cell cycle | 21.3115 | 4 | no |
| GO:0051050 | positive regulation of transport | 21.3115 | 4 | no |
| GO:0002429 | immune response-activating cell surface receptor signaling pathway | 21.3115 | 4 | yes |
| GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 21.3115 | 4 | yes |
| GO:0018193 | peptidyl-amino acid modification | 19.6721 | 5 | yes |
| GO:0032103 | positive regulation of response to external stimulus | 19.6721 | 5 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 18.0328 | 5 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 16.3934 | 5 | yes |
| GO:0050727 | regulation of inflammatory response | 16.3934 | 5 | yes |
| GO:0002683 | negative regulation of immune system process | 16.3934 | 4 | yes |
| GO:0010638 | positive regulation of organelle organization | 16.3934 | 6 | yes |
| GO:0018108 | peptidyl-tyrosine phosphorylation | 16.3934 | 6 | yes |
| GO:0018212 | peptidyl-tyrosine modification | 16.3934 | 6 | yes |
| GO:0030100 | regulation of endocytosis | 16.3934 | 5 | yes |
| GO:0032102 | negative regulation of response to external stimulus | 16.3934 | 5 | yes |
| GO:0038093 | Fc receptor signaling pathway | 16.3934 | 5 | yes |
| GO:0045088 | regulation of innate immune response | 14.7541 | 5 | yes |
| GO:0046777 | protein autophosphorylation | 14.7541 | 6 | yes |
| GO:0050728 | negative regulation of inflammatory response | 14.7541 | 6 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 14.7541 | 6 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 14.7541 | 5 | yes |
| GO:0002831 | regulation of response to biotic stimulus | 14.7541 | 4 | yes |
| GO:0031348 | negative regulation of defense response | 14.7541 | 5 | yes |
| GO:0031349 | positive regulation of defense response | 14.7541 | 5 | yes |
| GO:0045089 | positive regulation of innate immune response | 13.1148 | 6 | yes |
| GO:0002833 | positive regulation of response to biotic stimulus | 13.1148 | 5 | yes |
| GO:0007229 | integrin-mediated signaling pathway | 13.1148 | 4 | yes |
| GO:0038094 | Fc-gamma receptor signaling pathway | 13.1148 | 6 | yes |
| GO:0050777 | negative regulation of immune response | 11.4754 | 5 | yes |
| GO:0140546 | defense response to symbiont | 11.4754 | 4 | yes |
| GO:1902115 | regulation of organelle assembly | 11.4754 | 5 | yes |
| GO:1902905 | positive regulation of supramolecular fiber organization | 11.4754 | 6 | yes |
| GO:0002431 | Fc receptor mediated stimulatory signaling pathway | 11.4754 | 5 | yes |
| GO:0019221 | cytokine-mediated signaling pathway | 11.4754 | 4 | yes |
| GO:0031334 | positive regulation of protein-containing complex assembly | 11.4754 | 6 | yes |
| GO:0032271 | regulation of protein polymerization | 11.4754 | 6 | yes |
| GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | 11.4754 | 4 | yes |
| GO:0046903 | secretion | 9.8361 | 4 | yes |
| GO:0051495 | positive regulation of cytoskeleton organization | 9.8361 | 7 | yes |
| GO:0002861 | regulation of inflammatory response to antigenic stimulus | 9.8361 | 5 | yes |
| GO:0002862 | negative regulation of inflammatory response to antigenic stimulus | 9.8361 | 6 | yes |
| GO:0032273 | positive regulation of protein polymerization | 9.8361 | 7 | yes |
| GO:0032956 | regulation of actin cytoskeleton organization | 9.8361 | 5 | yes |
| GO:0032970 | regulation of actin filament-based process | 9.8361 | 4 | yes |
| GO:0110053 | regulation of actin filament organization | 8.1967 | 6 | yes |
| GO:0002758 | innate immune response-activating signaling pathway | 8.1967 | 4 | yes |
| GO:0022604 | regulation of cell morphogenesis | 8.1967 | 5 | yes |
| GO:0045055 | regulated exocytosis | 6.5574 | 4 | yes |
| GO:0006954 | inflammatory response | 6.5574 | 4 | yes |
| GO:0032535 | regulation of cellular component size | 6.5574 | 4 | yes |
| GO:0050764 | regulation of phagocytosis | 4.9180 | 6 | yes |
| GO:0071801 | regulation of podosome assembly | 4.9180 | 6 | yes |
| GO:0008064 | regulation of actin polymerization or depolymerization | 4.9180 | 6 | yes |
| GO:0030832 | regulation of actin filament length | 4.9180 | 5 | yes |
| GO:0030833 | regulation of actin filament polymerization | 4.9180 | 7 | yes |
| GO:0030838 | positive regulation of actin filament polymerization | 4.9180 | 7 | yes |
| GO:0031663 | lipopolysaccharide-mediated signaling pathway | 4.9180 | 4 | yes |
| GO:0045728 | respiratory burst after phagocytosis | 3.2787 | 4 | yes |
| GO:0060333 | type II interferon-mediated signaling pathway | 3.2787 | 6 | yes |
| GO:0140888 | interferon-mediated signaling pathway | 3.2787 | 5 | yes |
| GO:0007498 | mesoderm development | 3.2787 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ABL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| WIPF1_HUMAN | [view interactions] | Low throughput | no | no |
| ELMO1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SOS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CBLB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RUFY1_HUMAN | [view interactions] | Low throughput | no | yes |
| SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| BTK_HUMAN | [view interactions] | Low throughput | no | no |
| ADA22_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ITB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DIAP1_HUMAN | [view interactions] | Low throughput | no | yes |
| LOX5_HUMAN | [view interactions] | Low throughput | no | no |
| SPR2A_HUMAN | [view interactions] | Low throughput | no | no |
| RPGF1_HUMAN | [view interactions] | Low throughput | no | yes |
| BCR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CBL_HUMAN | [view interactions] | Low throughput | no | yes |
| SKAP2_HUMAN | [view interactions] | Low throughput | no | no |
| PECA1_HUMAN | [view interactions] | Low throughput | no | no |
| CCR3_HUMAN | [view interactions] | Low throughput | no | yes |
| CSF3R_HUMAN | [view interactions] | Low throughput | no | yes |
| CHSTF_HUMAN | [view interactions] | Low throughput | no | yes |
| IL6RB_HUMAN | [view interactions] | Low throughput | no | no |
| TRPV4_HUMAN | [view interactions] | Low throughput | no | yes |
| RASA3_HUMAN | [view interactions] | Low throughput | no | yes |
| RASA1_HUMAN | [view interactions] | Low throughput | no | yes |
| FCGR1_HUMAN | [view interactions] | Low throughput | no | no |
| DVL2_HUMAN | [view interactions] | Low throughput | no | yes |
| P73_HUMAN | [view interactions] | Low throughput | no | no |
| FLT3_HUMAN | [view interactions] | Low throughput | no | no |
| HCK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| U119A_HUMAN | [view interactions] | Low throughput | no | no |
| BCAR1_HUMAN | [view interactions] | Low throughput | no | yes |
| RL10_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CBP_HUMAN | [view interactions] | Low throughput | no | yes |
| ACK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STAT3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MDM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GPVI_HUMAN | [view interactions] | Low throughput | no | no |
| ADA15_HUMAN | [view interactions] | Low throughput | no | yes |
| KHDR1_HUMAN | [view interactions] | Low throughput | no | yes |
| PDC6I_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NAL12_HUMAN | [view interactions] | Low throughput | no | yes |
| WASP_HUMAN | [view interactions] | Low throughput | no | yes |
| H90B2_HUMAN | [view interactions] | High throughput | no | no |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| CHD5_HUMAN | [view interactions] | High throughput | no | no |
| CHD3_HUMAN | [view interactions] | High throughput | no | yes |
| CHD4_HUMAN | [view interactions] | High throughput | no | yes |
| KPRA_HUMAN | [view interactions] | High throughput | no | no |
| AKA12_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP76_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMDH2_HUMAN | [view interactions] | High throughput | no | yes |
| PRPS2_HUMAN | [view interactions] | High throughput | no | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H90B3_HUMAN | [view interactions] | High throughput | no | no |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRC1_HUMAN | [view interactions] | High throughput | no | no |
| HNRPC_HUMAN | [view interactions] | High throughput | no | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TXD12_HUMAN | [view interactions] | High throughput | no | no |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KPRB_HUMAN | [view interactions] | High throughput | no | yes |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DPP2_HUMAN | [view interactions] | High throughput | no | yes |
| RL37_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MAGB2_HUMAN | [view interactions] | High throughput | no | no |
| DYN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHIP1_HUMAN | [view interactions] | High throughput | no | no |
| SH3K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EVL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD2AP_HUMAN | [view interactions] | High throughput | no | no |
| 3BP1_HUMAN | [view interactions] | High throughput | no | no |
| TS101_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDCP_HUMAN | [view interactions] | High throughput | no | yes |
| P85B_HUMAN | [view interactions] | High throughput | no | yes |
| LCP2_HUMAN | [view interactions] | High throughput | no | yes |
| P85A_HUMAN | [view interactions] | High throughput | no | yes |
| NUCL_HUMAN | [view interactions] | High throughput | no | yes |
| SF3B3_HUMAN | [view interactions] | High throughput | no | yes |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRP4B_HUMAN | [view interactions] | High throughput | no | yes |
| PTN11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSKP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IRAK2_HUMAN | [view interactions] | High throughput | no | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RT02_HUMAN | [view interactions] | High throughput | no | no |
| ADCK2_HUMAN | [view interactions] | High throughput | no | yes |
| STK33_HUMAN | [view interactions] | High throughput | no | no |
| CD177_HUMAN | [view interactions] | High throughput | no | no |
| ABL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WNT2_HUMAN | [view interactions] | High throughput | no | no |
| KR109_HUMAN | [view interactions] | High throughput | no | no |
| MTUS2_HUMAN | [view interactions] | High throughput | no | yes |
| K1C40_HUMAN | [view interactions] | High throughput | no | no |
| GOPC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NT2NA_HUMAN | [view interactions] | High throughput | no | no |
| M4K5_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| ERBB3_HUMAN | [view interactions] | High throughput | no | yes |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| GAB1_HUMAN | [view interactions] | High throughput | no | yes |
| KIT_HUMAN | [view interactions] | High throughput | no | no |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PK3CB_HUMAN | [view interactions] | High throughput | no | yes |
| VGFR1_HUMAN | [view interactions] | High throughput | no | no |
| PLCG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRKL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NGEF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P55G_HUMAN | [view interactions] | High throughput | no | yes |
| FRS3_HUMAN | [view interactions] | High throughput | no | no |
| LTMD1_HUMAN | [view interactions] | High throughput | no | no |
| OLIG1_HUMAN | [view interactions] | High throughput | no | no |
| FAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRB14_HUMAN | [view interactions] | High throughput | no | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRIM1_HUMAN | [view interactions] | High throughput | no | no |
| TRIP6_HUMAN | [view interactions] | High throughput | no | yes |
| K1H1_HUMAN | [view interactions] | High throughput | no | no |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| MK_HUMAN | [view interactions] | High throughput | no | no |
| FHL5_HUMAN | [view interactions] | High throughput | no | no |
| TOX2_HUMAN | [view interactions] | High throughput | no | no |
| KRT36_HUMAN | [view interactions] | High throughput | no | no |
| KRT34_HUMAN | [view interactions] | High throughput | no | no |
| RBPMS_HUMAN | [view interactions] | High throughput | no | no |
| HSF2B_HUMAN | [view interactions] | High throughput | no | yes |
| SH2B2_HUMAN | [view interactions] | High throughput | no | yes |
| TEKT4_HUMAN | [view interactions] | High throughput | no | no |
| AP4AT_HUMAN | [view interactions] | High throughput | no | no |
| NEUFC_HUMAN | [view interactions] | High throughput | no | yes |
| CC88B_HUMAN | [view interactions] | High throughput | no | no |
| PNMA1_HUMAN | [view interactions] | High throughput | no | yes |
| MKRN3_HUMAN | [view interactions] | High throughput | no | yes |
| ZSCA4_HUMAN | [view interactions] | High throughput | no | no |
| CTG1B_HUMAN | [view interactions] | High throughput | no | no |
| KR108_HUMAN | [view interactions] | High throughput | no | no |
| KRA11_HUMAN | [view interactions] | High throughput | no | no |
| PKHG4_HUMAN | [view interactions] | High throughput | no | no |
| INCA1_HUMAN | [view interactions] | High throughput | no | no |
| KRT35_HUMAN | [view interactions] | High throughput | no | no |
| CRTP1_HUMAN | [view interactions] | High throughput | no | yes |
| BPIA1_HUMAN | [view interactions] | High throughput | no | no |
| KPRP_HUMAN | [view interactions] | High throughput | no | no |
| TRI27_HUMAN | [view interactions] | High throughput | no | yes |
| KRA31_HUMAN | [view interactions] | High throughput | no | no |
| KRA13_HUMAN | [view interactions] | High throughput | no | no |
| KR107_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| CA074_HUMAN | [view interactions] | High throughput | no | no |
| PAXI_HUMAN | [view interactions] | High throughput | no | yes |
| LEG1_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EPHA2_HUMAN | [view interactions] | High throughput | no | no |
| PNMT_HUMAN | [view interactions] | High throughput | no | no |
| BLK_HUMAN | [view interactions] | High throughput | no | no |
| SRMS_HUMAN | [view interactions] | High throughput | no | no |
| FGR_HUMAN | [view interactions] | High throughput | no | no |
| YES_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DOK1_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ERBB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MBP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DOK2_HUMAN | [view interactions] | High throughput | no | no |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| CNPY3_HUMAN | [view interactions] | High throughput | no | yes |
| PAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TNFL6_HUMAN | [view interactions] | High throughput | no | yes |
| ADA12_HUMAN | [view interactions] | High throughput | no | no |
| ADA19_HUMAN | [view interactions] | High throughput | no | no |
| MED28_HUMAN | [view interactions] | High throughput | no | yes |
| TMG4_HUMAN | [view interactions] | High throughput | no | yes |
| FHL2_HUMAN | [view interactions] | High throughput | no | yes |
| RBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NS1BP_HUMAN | [view interactions] | High throughput | no | yes |
| PGAM5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |