Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AKA12_HUMAN

GO
G2C
SynGO

Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). [View more on UniProt]

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Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in AKA12_HUMAN
GO:0043168 anion binding 58.6667 4 no
GO:0000166 nucleotide binding 57.3333 4 no
GO:0017076 purine nucleotide binding 56.0000 5 no
GO:0032555 purine ribonucleotide binding 54.6667 4 no
GO:0035639 purine ribonucleoside triphosphate binding 50.6667 4 no
GO:0030554 adenyl nucleotide binding 33.3333 6 no
GO:0032559 adenyl ribonucleotide binding 32.0000 5 no
GO:0016462 pyrophosphatase activity 29.3333 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 29.3333 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 29.3333 6 no
GO:0005524 ATP binding 28.0000 5 no
GO:0019900 kinase binding 28.0000 4 no
GO:0019901 protein kinase binding 26.6667 5 no
GO:0019001 guanyl nucleotide binding 24.0000 6 no
GO:0032561 guanyl ribonucleotide binding 24.0000 5 no
GO:0003924 GTPase activity 22.6667 7 no
GO:0005525 GTP binding 22.6667 5 no
GO:0008179 adenylate cyclase binding 4.0000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in AKA12_HUMAN
GO:0048522 positive regulation of cellular process 76.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 61.3333 4 yes
GO:0031323 regulation of cellular metabolic process 58.6667 4 yes
GO:0010646 regulation of cell communication 57.3333 4 yes
GO:0080090 regulation of primary metabolic process 57.3333 4 no
GO:0048523 negative regulation of cellular process 56.0000 4 no
GO:0051128 regulation of cellular component organization 53.3333 4 no
GO:0009966 regulation of signal transduction 52.0000 4 yes
GO:0009893 positive regulation of metabolic process 50.6667 4 yes
GO:0009889 regulation of biosynthetic process 49.3333 4 yes
GO:1902531 regulation of intracellular signal transduction 49.3333 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 48.0000 5 yes
GO:0031326 regulation of cellular biosynthetic process 48.0000 5 yes
GO:0010468 regulation of gene expression 46.6667 6 yes
GO:0048584 positive regulation of response to stimulus 46.6667 4 yes
GO:0006996 organelle organization 46.6667 4 no
GO:0051246 regulation of protein metabolic process 46.6667 5 no
GO:0010604 positive regulation of macromolecule metabolic process 45.3333 5 yes
GO:0010647 positive regulation of cell communication 42.6667 5 yes
GO:0023056 positive regulation of signaling 42.6667 4 yes
GO:0031325 positive regulation of cellular metabolic process 41.3333 5 yes
GO:0051049 regulation of transport 41.3333 4 no
GO:0044087 regulation of cellular component biogenesis 41.3333 4 no
GO:0008104 protein localization 38.6667 4 no
GO:0009967 positive regulation of signal transduction 37.3333 5 yes
GO:0007010 cytoskeleton organization 37.3333 5 no
GO:0031399 regulation of protein modification process 37.3333 6 no
GO:0033043 regulation of organelle organization 37.3333 5 no
GO:0060341 regulation of cellular localization 37.3333 4 no
GO:0051247 positive regulation of protein metabolic process 36.0000 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 36.0000 5 no
GO:1902533 positive regulation of intracellular signal transduction 34.6667 6 yes
GO:0019220 regulation of phosphate metabolic process 34.6667 6 no
GO:0051174 regulation of phosphorus metabolic process 34.6667 5 no
GO:0022607 cellular component assembly 34.6667 4 no
GO:0051240 positive regulation of multicellular organismal process 33.3333 4 yes
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0030334 regulation of cell migration 32.0000 5 yes
GO:2000145 regulation of cell motility 32.0000 4 yes
GO:0042325 regulation of phosphorylation 32.0000 7 no
GO:0051130 positive regulation of cellular component organization 32.0000 5 no
GO:0141124 intracellular signaling cassette 32.0000 4 no
GO:0032880 regulation of protein localization 32.0000 5 no
GO:0071310 cellular response to organic substance 30.6667 4 yes
GO:0031324 negative regulation of cellular metabolic process 30.6667 5 no
GO:0001932 regulation of protein phosphorylation 30.6667 7 no
GO:0042127 regulation of cell population proliferation 30.6667 4 no
GO:0030335 positive regulation of cell migration 29.3333 6 yes
GO:0040017 positive regulation of locomotion 29.3333 4 yes
GO:0042981 regulation of apoptotic process 29.3333 5 yes
GO:0043067 regulation of programmed cell death 29.3333 4 yes
GO:2000147 positive regulation of cell motility 29.3333 5 yes
GO:0031344 regulation of cell projection organization 29.3333 5 no
GO:0031401 positive regulation of protein modification process 29.3333 7 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 29.3333 6 no
GO:0006796 phosphate-containing compound metabolic process 28.0000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 28.0000 5 no
GO:0036211 protein modification process 28.0000 4 no
GO:0043412 macromolecule modification 28.0000 4 no
GO:0071702 organic substance transport 28.0000 4 no
GO:0071705 nitrogen compound transport 28.0000 4 no
GO:0044089 positive regulation of cellular component biogenesis 28.0000 5 no
GO:0051252 regulation of RNA metabolic process 28.0000 5 no
GO:0009891 positive regulation of biosynthetic process 26.6667 5 yes
GO:0002684 positive regulation of immune system process 26.6667 4 no
GO:0010562 positive regulation of phosphorus metabolic process 26.6667 6 no
GO:0030030 cell projection organization 26.6667 4 no
GO:0043085 positive regulation of catalytic activity 26.6667 4 no
GO:0045937 positive regulation of phosphate metabolic process 26.6667 7 no
GO:1901701 cellular response to oxygen-containing compound 26.6667 4 no
GO:0022603 regulation of anatomical structure morphogenesis 26.6667 4 no
GO:0006355 regulation of DNA-templated transcription 26.6667 7 no
GO:2001141 regulation of RNA biosynthetic process 26.6667 6 no
GO:0031328 positive regulation of cellular biosynthetic process 25.3333 6 yes
GO:0043408 regulation of MAPK cascade 25.3333 6 yes
GO:0042327 positive regulation of phosphorylation 25.3333 8 no
GO:0048585 negative regulation of response to stimulus 25.3333 4 no
GO:0060627 regulation of vesicle-mediated transport 25.3333 4 no
GO:0051493 regulation of cytoskeleton organization 25.3333 6 no
GO:0010557 positive regulation of macromolecule biosynthetic process 24.0000 6 yes
GO:0001934 positive regulation of protein phosphorylation 24.0000 8 no
GO:0008284 positive regulation of cell population proliferation 24.0000 5 no
GO:0009968 negative regulation of signal transduction 24.0000 5 no
GO:0010648 negative regulation of cell communication 24.0000 5 no
GO:0023057 negative regulation of signaling 24.0000 4 no
GO:0051094 positive regulation of developmental process 24.0000 4 no
GO:0051338 regulation of transferase activity 24.0000 4 no
GO:0010638 positive regulation of organelle organization 24.0000 6 no
GO:0015031 protein transport 24.0000 4 no
GO:0030155 regulation of cell adhesion 22.6667 4 no
GO:0043549 regulation of kinase activity 22.6667 5 no
GO:0120036 plasma membrane bounded cell projection organization 22.6667 5 no
GO:0051050 positive regulation of transport 22.6667 4 no
GO:1903829 positive regulation of protein localization 22.6667 5 no
GO:0050804 modulation of chemical synaptic transmission 21.3333 5 yes
GO:0099177 regulation of trans-synaptic signaling 21.3333 4 yes
GO:0032101 regulation of response to external stimulus 21.3333 4 no
GO:0045859 regulation of protein kinase activity 21.3333 6 no
GO:0050776 regulation of immune response 21.3333 4 no
GO:0080134 regulation of response to stress 21.3333 4 no
GO:2000026 regulation of multicellular organismal development 21.3333 4 no
GO:0032970 regulation of actin filament-based process 21.3333 4 no
GO:0043410 positive regulation of MAPK cascade 20.0000 7 yes
GO:0010628 positive regulation of gene expression 17.3333 7 yes
GO:0001817 regulation of cytokine production 16.0000 4 yes
GO:0033993 response to lipid 14.6667 4 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 13.3333 7 yes
GO:0043065 positive regulation of apoptotic process 12.0000 6 yes
GO:0043068 positive regulation of programmed cell death 12.0000 5 yes
GO:0034097 response to cytokine 10.6667 4 yes
GO:0001819 positive regulation of cytokine production 9.3333 5 yes
GO:0070374 positive regulation of ERK1 and ERK2 cascade 9.3333 8 yes
GO:0003018 vascular process in circulatory system 8.0000 4 yes
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 8.0000 4 yes
GO:0071345 cellular response to cytokine stimulus 8.0000 5 yes
GO:0002237 response to molecule of bacterial origin 6.6667 4 yes
GO:0032496 response to lipopolysaccharide 6.6667 4 yes
GO:0010762 regulation of fibroblast migration 5.3333 6 yes
GO:0070555 response to interleukin-1 5.3333 5 yes
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 4.0000 5 yes
GO:0010738 regulation of protein kinase A signaling 4.0000 6 yes
GO:0010739 positive regulation of protein kinase A signaling 4.0000 7 yes
GO:0010763 positive regulation of fibroblast migration 4.0000 7 yes
GO:0034350 regulation of glial cell apoptotic process 4.0000 6 yes
GO:0034612 response to tumor necrosis factor 4.0000 5 yes
GO:0043116 negative regulation of vascular permeability 4.0000 4 yes
GO:0051769 regulation of nitric-oxide synthase biosynthetic process 4.0000 6 yes
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process 4.0000 7 yes
GO:0071356 cellular response to tumor necrosis factor 4.0000 6 yes
GO:0032680 regulation of tumor necrosis factor production 2.6667 6 yes
GO:0032760 positive regulation of tumor necrosis factor production 2.6667 7 yes
GO:0034352 positive regulation of glial cell apoptotic process 2.6667 7 yes
GO:0035733 hepatic stellate cell activation 2.6667 4 yes
GO:0061869 regulation of hepatic stellate cell migration 2.6667 7 yes
GO:0061870 positive regulation of hepatic stellate cell migration 2.6667 8 yes
GO:0071347 cellular response to interleukin-1 2.6667 6 yes
GO:0090036 regulation of protein kinase C signaling 2.6667 6 yes
GO:1900141 regulation of oligodendrocyte apoptotic process 2.6667 7 yes
GO:1900143 positive regulation of oligodendrocyte apoptotic process 2.6667 8 yes
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 2.6667 5 yes
GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production 2.6667 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
HDAC7_HUMAN [view interactions] Low throughput no no
CDK1_HUMAN [view interactions] Low throughput no no
KPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
KAP2_HUMAN [view entry] [view interactions] Low throughput yes yes
PDE4D_HUMAN [view entry] [view interactions] Low throughput yes yes
ADRB2_HUMAN [view entry] [view interactions] Low throughput yes no
PLK1_HUMAN [view interactions] Low throughput no yes
HDAC6_HUMAN [view interactions] Low throughput no yes
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
DYHC1_HUMAN [view entry] [view interactions] High throughput yes yes
DC1I2_HUMAN [view entry] [view interactions] High throughput yes yes
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
DC1L1_HUMAN [view entry] [view interactions] High throughput yes yes
DLRB1_HUMAN [view entry] [view interactions] High throughput yes no
K1549_HUMAN [view entry] [view interactions] High throughput yes yes
WDHD1_HUMAN [view interactions] High throughput no no
MTOR_HUMAN [view entry] [view interactions] High throughput yes yes
COPD_HUMAN [view entry] [view interactions] High throughput yes yes
P4R3A_HUMAN [view interactions] High throughput no yes
GCP60_HUMAN [view interactions] High throughput no yes
SYF1_HUMAN [view interactions] High throughput no no
BIG1_HUMAN [view interactions] High throughput no yes
TRI14_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
RHDF2_HUMAN [view interactions] High throughput no yes
RN183_HUMAN [view interactions] High throughput no no
CK052_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP2_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
OCLN_HUMAN [view interactions] High throughput no no
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
STX6_HUMAN [view interactions] High throughput no yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
ZFPL1_HUMAN [view interactions] High throughput no yes
NAA40_HUMAN [view interactions] High throughput no no
AMPN_HUMAN [view interactions] High throughput no no
TOLIP_HUMAN [view entry] [view interactions] High throughput yes yes
UFO_HUMAN [view interactions] High throughput no no
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
ARL4C_HUMAN [view interactions] High throughput no yes
AR13B_HUMAN [view interactions] High throughput no yes
ARL14_HUMAN [view interactions] High throughput no no
ARL15_HUMAN [view interactions] High throughput no yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
FOXO1_HUMAN [view interactions] High throughput no yes
KBTB4_HUMAN [view interactions] High throughput no yes
RAB18_HUMAN [view entry] [view interactions] High throughput yes yes
MUC18_HUMAN [view interactions] High throughput no yes
FHL1_HUMAN [view interactions] High throughput no no
FTM_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
RIPK4_HUMAN [view interactions] High throughput no no
CE290_HUMAN [view interactions] High throughput no no
OFD1_HUMAN [view interactions] High throughput no yes
SCLT1_HUMAN [view interactions] High throughput no yes
RASA1_HUMAN [view interactions] High throughput no yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
SH3K1_HUMAN [view entry] [view interactions] High throughput yes yes
SH2D3_HUMAN [view interactions] High throughput no no
KAP0_HUMAN [view entry] [view interactions] High throughput yes yes
PDPK1_HUMAN [view entry] [view interactions] High throughput yes yes
SH3G3_HUMAN [view entry] [view interactions] High throughput yes no
ABI1_HUMAN [view entry] [view interactions] High throughput yes yes
CASP9_HUMAN [view interactions] High throughput no yes
MP2K3_HUMAN [view entry] [view interactions] High throughput yes yes
KPCE_HUMAN [view entry] [view interactions] High throughput yes yes
DOK2_HUMAN [view interactions] High throughput no no
PAK1_HUMAN [view entry] [view interactions] High throughput yes yes
HCK_HUMAN [view entry] [view interactions] High throughput yes no
KPCB_HUMAN [view entry] [view interactions] High throughput yes yes
SHC1_HUMAN [view entry] [view interactions] High throughput yes yes
MP2K1_HUMAN [view entry] [view interactions] High throughput yes yes
ELK4_HUMAN [view interactions] High throughput no yes
CAV2_HUMAN [view interactions] High throughput no no
SRC_HUMAN [view entry] [view interactions] High throughput yes no
KPCD1_HUMAN [view interactions] High throughput no yes
MIA40_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
MYCB2_HUMAN [view entry] [view interactions] High throughput yes no
CFTR_HUMAN [view interactions] High throughput no no
DYR1A_HUMAN [view interactions] High throughput no yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
PPIA_HUMAN [view entry] [view interactions] High throughput yes yes
TRFE_HUMAN [view interactions] High throughput no no
KPYM_HUMAN [view interactions] High throughput no yes
AKA12_HUMAN [view entry] [view interactions] High throughput yes no
SPR2E_HUMAN [view interactions] High throughput no no
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
CTDP1_HUMAN [view interactions] High throughput no yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
SCO1_HUMAN [view interactions] High throughput no yes
SFXN1_HUMAN [view entry] [view interactions] High throughput yes yes
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
KCNK3_HUMAN [view interactions] High throughput no no
KIF3C_HUMAN [view interactions] High throughput no no
KIF3B_HUMAN [view entry] [view interactions] High throughput yes no
STK4_HUMAN [view interactions] High throughput no yes
DYRK2_HUMAN [view interactions] High throughput no yes
NECT2_HUMAN [view interactions] High throughput no no
SAV1_HUMAN [view interactions] High throughput no yes
POF1B_HUMAN [view interactions] High throughput no no
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
SPRTN_HUMAN [view interactions] High throughput no yes
CP250_HUMAN [view interactions] High throughput no no
P53_HUMAN [view interactions] High throughput no no
GCP3_HUMAN [view interactions] High throughput no yes
EID3_HUMAN [view interactions] High throughput no no
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
SIN3B_HUMAN [view interactions] High throughput no yes
SAMH1_HUMAN [view interactions] High throughput no yes
SGTB_HUMAN [view interactions] High throughput no yes
AMOT_HUMAN [view entry] [view interactions] High throughput yes no
PDLI5_HUMAN [view entry] [view interactions] High throughput yes no
SAM50_HUMAN [view entry] [view interactions] High throughput yes yes
CARF_HUMAN [view interactions] High throughput no yes
SDCG8_HUMAN [view interactions] High throughput no yes
TZAP_HUMAN [view interactions] High throughput no no
CHMP6_HUMAN [view interactions] High throughput no yes
CE170_HUMAN [view interactions] High throughput no yes
CAF1A_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
BRCA1_HUMAN [view interactions] High throughput no yes
ZN598_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
TFE3_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
HS12A_HUMAN [view entry] [view interactions] High throughput yes yes
HS12B_HUMAN [view interactions] High throughput no yes
FBX32_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND3_HUMAN [view interactions] High throughput no no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
G3P_HUMAN [view entry] [view interactions] High throughput yes yes
LDHA_HUMAN [view entry] [view interactions] High throughput yes yes
ORC4_HUMAN [view interactions] High throughput no yes
KAPCA_HUMAN [view entry] [view interactions] High throughput yes yes
TRAP1_HUMAN [view entry] [view interactions] High throughput yes yes
ACADM_HUMAN [view interactions] High throughput no yes
NSDHL_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
CLD4_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes