DLRB1_HUMAN
Evidence for PS localization
Functions
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DLRB1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 22.5000 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 22.5000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 22.5000 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DLRB1_HUMAN |
|---|---|---|---|---|
| GO:0006996 | organelle organization | 57.5000 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 55.0000 | 4 | no |
| GO:0007010 | cytoskeleton organization | 47.5000 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 45.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 42.5000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 35.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 35.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 32.5000 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 32.5000 | 4 | no |
| GO:0033043 | regulation of organelle organization | 32.5000 | 5 | no |
| GO:0009966 | regulation of signal transduction | 30.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 30.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 30.0000 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 30.0000 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 27.5000 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 27.5000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 27.5000 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 27.5000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 27.5000 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0031399 | regulation of protein modification process | 25.0000 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.0000 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 25.0000 | 6 | no |
| GO:0009892 | negative regulation of metabolic process | 22.5000 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.5000 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 22.5000 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.5000 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.5000 | 6 | no |
| GO:0010638 | positive regulation of organelle organization | 22.5000 | 6 | no |
| GO:0030030 | cell projection organization | 22.5000 | 4 | no |
| GO:0097435 | supramolecular fiber organization | 22.5000 | 4 | no |
| GO:0051049 | regulation of transport | 22.5000 | 4 | no |
| GO:0051726 | regulation of cell cycle | 22.5000 | 4 | no |
| GO:0009416 | response to light stimulus | 7.5000 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in DLRB1_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 7.5000 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 7.5000 | 5 | no |
| DOID:114 | heart disease | 7.5000 | 3 | no |
| DOID:2843 | long QT syndrome | 5.0000 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CPEB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DC1I2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HS105_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NUDC_HUMAN | [view interactions] | Low throughput | no | yes |
| NAGK_HUMAN | [view interactions] | Low throughput | no | no |
| DLRB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| B2L11_HUMAN | [view interactions] | Low throughput | no | yes |
| B2CL1_HUMAN | [view interactions] | Low throughput | no | yes |
| DC2I1_HUMAN | [view interactions] | Low throughput | no | yes |
| P2RY6_HUMAN | [view interactions] | High throughput | no | no |
| PHLA3_HUMAN | [view interactions] | High throughput | no | yes |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| EPB41_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MAGA2_HUMAN | [view interactions] | High throughput | no | no |
| DC1I1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYLT1_HUMAN | [view interactions] | High throughput | no | no |
| DYT2B_HUMAN | [view interactions] | High throughput | no | no |
| DRC5_HUMAN | [view interactions] | High throughput | no | no |
| PALS2_HUMAN | [view interactions] | High throughput | no | yes |
| RPC9_HUMAN | [view interactions] | High throughput | no | yes |
| YTHD1_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CENPE_HUMAN | [view interactions] | High throughput | no | no |
| LNX1_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| MIA40_HUMAN | [view interactions] | High throughput | no | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC2L1_HUMAN | [view interactions] | High throughput | no | no |
| DYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATRX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| FLNC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PLOD3_HUMAN | [view interactions] | High throughput | no | yes |
| SEPT2_HUMAN | [view interactions] | High throughput | no | no |
| LTOR2_HUMAN | [view interactions] | High throughput | no | yes |
| SAFB1_HUMAN | [view interactions] | High throughput | no | yes |
| RT26_HUMAN | [view interactions] | High throughput | no | yes |
| AKA12_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHG2_HUMAN | [view interactions] | High throughput | no | no |
| ELP6_HUMAN | [view interactions] | High throughput | no | no |
| OSGEP_HUMAN | [view interactions] | High throughput | no | yes |
| BCAP_HUMAN | [view interactions] | High throughput | no | no |
| MORC3_HUMAN | [view interactions] | High throughput | no | yes |
| ODB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DRG2_HUMAN | [view interactions] | High throughput | no | yes |
| ZN507_HUMAN | [view interactions] | High throughput | no | no |
| K1C19_HUMAN | [view interactions] | High throughput | no | no |
| RHG05_HUMAN | [view interactions] | High throughput | no | yes |
| SMG7_HUMAN | [view interactions] | High throughput | no | no |
| ELL_HUMAN | [view interactions] | High throughput | no | no |
| UNK_HUMAN | [view interactions] | High throughput | no | yes |
| SGT1_HUMAN | [view interactions] | High throughput | no | no |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | yes |
| 4ET_HUMAN | [view interactions] | High throughput | no | yes |
| NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| MPH6_HUMAN | [view interactions] | High throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| DCTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF11_HUMAN | [view interactions] | High throughput | no | yes |
| DYLT3_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBR2_HUMAN | [view interactions] | High throughput | no | yes |
| DC1L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LUC7L_HUMAN | [view interactions] | High throughput | no | yes |
| RAGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCD82_HUMAN | [view interactions] | High throughput | no | yes |
| DC2I2_HUMAN | [view interactions] | High throughput | no | yes |
| CENPJ_HUMAN | [view interactions] | High throughput | no | no |
| LIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MPP8_HUMAN | [view interactions] | High throughput | no | yes |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRDN_HUMAN | [view interactions] | High throughput | no | no |
| SHLD3_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN6_HUMAN | [view interactions] | Computational | no | no |
| DYLT5_HUMAN | [view interactions] | Computational | no | no |
| SMAD2_HUMAN | [view interactions] | Computational | no | yes |
| CAZA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TGFB3_HUMAN | [view interactions] | Computational | no | no |
| TGFR2_HUMAN | [view interactions] | Computational | no | no |
| TGFR1_HUMAN | [view interactions] | Computational | no | no |
| NUDC3_HUMAN | [view interactions] | Computational | no | yes |
| ARP10_HUMAN | [view interactions] | Computational | no | no |
| SMUF2_HUMAN | [view interactions] | Computational | no | yes |
| DYLT2_HUMAN | [view interactions] | Computational | no | no |
| DLRB2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| DCTN5_HUMAN | [view interactions] | Computational | no | yes |