CPEB1_HUMAN
Evidence for PS localization
Functions
Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5-UUUUUAU-3) within the mRNA 3-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed). In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation . Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses . Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation . Induces the assembly of stress granules in the absence of stress. Required for cell cycle progression, specifically for prophase entry (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CPEB1_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 63.8889 | 4 | yes |
| GO:0003729 | mRNA binding | 30.5556 | 5 | yes |
| GO:0005524 | ATP binding | 25.0000 | 5 | no |
| GO:0017076 | purine nucleotide binding | 25.0000 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 25.0000 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 25.0000 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 25.0000 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.0000 | 4 | no |
| GO:0003730 | mRNA 3-UTR binding | 19.4444 | 6 | yes |
| GO:0046872 | metal ion binding | 16.6667 | 4 | yes |
| GO:0035925 | mRNA 3-UTR AU-rich region binding | 8.3333 | 7 | yes |
| GO:0043022 | ribosome binding | 8.3333 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CPEB1_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 61.1111 | 4 | yes |
| GO:0010468 | regulation of gene expression | 58.3333 | 5 | yes |
| GO:0031323 | regulation of cellular metabolic process | 58.3333 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 58.3333 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 58.3333 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 55.5556 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 52.7778 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 50.0000 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 50.0000 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 50.0000 | 5 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 47.2222 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 47.2222 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 47.2222 | 5 | yes |
| GO:0051252 | regulation of RNA metabolic process | 47.2222 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 44.4444 | 5 | yes |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 44.4444 | 5 | yes |
| GO:0090304 | nucleic acid metabolic process | 41.6667 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 38.8889 | 4 | yes |
| GO:0010608 | post-transcriptional regulation of gene expression | 38.8889 | 6 | yes |
| GO:0010629 | negative regulation of gene expression | 38.8889 | 6 | yes |
| GO:0016070 | RNA metabolic process | 38.8889 | 5 | yes |
| GO:0006396 | RNA processing | 36.1111 | 6 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 36.1111 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 36.1111 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 33.3333 | 5 | yes |
| GO:0034248 | regulation of cellular amide metabolic process | 33.3333 | 5 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 33.3333 | 5 | yes |
| GO:0006417 | regulation of translation | 30.5556 | 6 | yes |
| GO:2000112 | regulation of cellular macromolecule biosynthetic process | 30.5556 | 6 | yes |
| GO:0009894 | regulation of catabolic process | 30.5556 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 27.7778 | 5 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 27.7778 | 6 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 27.7778 | 6 | yes |
| GO:0031329 | regulation of cellular catabolic process | 27.7778 | 5 | no |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 27.7778 | 6 | no |
| GO:0051253 | negative regulation of RNA metabolic process | 27.7778 | 6 | no |
| GO:0016071 | mRNA metabolic process | 25.0000 | 6 | yes |
| GO:0010646 | regulation of cell communication | 25.0000 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 25.0000 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.0000 | 6 | no |
| GO:0051128 | regulation of cellular component organization | 25.0000 | 4 | no |
| GO:0034249 | negative regulation of cellular amide metabolic process | 22.2222 | 6 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 22.2222 | 6 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 22.2222 | 6 | yes |
| GO:1903311 | regulation of mRNA metabolic process | 22.2222 | 6 | yes |
| GO:0022607 | cellular component assembly | 22.2222 | 4 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 22.2222 | 6 | no |
| GO:0006996 | organelle organization | 22.2222 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 22.2222 | 4 | no |
| GO:0006397 | mRNA processing | 19.4444 | 7 | yes |
| GO:0017148 | negative regulation of translation | 19.4444 | 7 | yes |
| GO:0051254 | positive regulation of RNA metabolic process | 19.4444 | 6 | yes |
| GO:0071310 | cellular response to organic substance | 19.4444 | 4 | yes |
| GO:2000113 | negative regulation of cellular macromolecule biosynthetic process | 19.4444 | 7 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 13.8889 | 4 | yes |
| GO:2000765 | regulation of cytoplasmic translation | 13.8889 | 7 | yes |
| GO:1901699 | cellular response to nitrogen compound | 11.1111 | 4 | yes |
| GO:1903313 | positive regulation of mRNA metabolic process | 11.1111 | 7 | yes |
| GO:0010243 | response to organonitrogen compound | 8.3333 | 4 | yes |
| GO:0032870 | cellular response to hormone stimulus | 8.3333 | 4 | yes |
| GO:0036293 | response to decreased oxygen levels | 8.3333 | 4 | yes |
| GO:0050684 | regulation of mRNA processing | 8.3333 | 7 | yes |
| GO:0071417 | cellular response to organonitrogen compound | 8.3333 | 4 | yes |
| GO:1901652 | response to peptide | 8.3333 | 4 | yes |
| GO:1901653 | cellular response to peptide | 8.3333 | 5 | yes |
| GO:2000766 | negative regulation of cytoplasmic translation | 8.3333 | 8 | yes |
| GO:0031440 | regulation of mRNA 3-end processing | 5.5556 | 8 | yes |
| GO:0031442 | positive regulation of mRNA 3-end processing | 5.5556 | 9 | yes |
| GO:0032868 | response to insulin | 5.5556 | 5 | yes |
| GO:0032869 | cellular response to insulin stimulus | 5.5556 | 6 | yes |
| GO:0036294 | cellular response to decreased oxygen levels | 5.5556 | 5 | yes |
| GO:0043200 | response to amino acid | 5.5556 | 4 | yes |
| GO:0043434 | response to peptide hormone | 5.5556 | 4 | yes |
| GO:0050685 | positive regulation of mRNA processing | 5.5556 | 8 | yes |
| GO:0071229 | cellular response to acid chemical | 5.5556 | 4 | yes |
| GO:0071230 | cellular response to amino acid stimulus | 5.5556 | 5 | yes |
| GO:0071375 | cellular response to peptide hormone stimulus | 5.5556 | 5 | yes |
| GO:0071453 | cellular response to oxygen levels | 5.5556 | 4 | yes |
| GO:0071456 | cellular response to hypoxia | 5.5556 | 4 | yes |
| GO:1900363 | regulation of mRNA polyadenylation | 5.5556 | 9 | yes |
| GO:1900365 | positive regulation of mRNA polyadenylation | 5.5556 | 10 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PAPD5_HUMAN | [view interactions] | Low throughput | no | no |
| MSI1H_HUMAN | [view interactions] | Low throughput | no | no |
| CPEB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KIF1B_HUMAN | [view interactions] | Low throughput | no | yes |
| MTAP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLRB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| APLP1_HUMAN | [view interactions] | Low throughput | no | yes |
| APLP2_HUMAN | [view interactions] | Low throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PIN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| JUN_HUMAN | [view interactions] | Low throughput | no | yes |
| F120A_HUMAN | [view interactions] | High throughput | no | yes |
| ATD3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZCHC3_HUMAN | [view interactions] | High throughput | no | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| DHX36_HUMAN | [view interactions] | High throughput | no | yes |
| XRN2_HUMAN | [view interactions] | High throughput | no | yes |
| HNRL1_HUMAN | [view interactions] | High throughput | no | yes |
| DDX50_HUMAN | [view interactions] | High throughput | no | yes |
| STRBP_HUMAN | [view interactions] | High throughput | no | yes |
| PURB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZFR_HUMAN | [view interactions] | High throughput | no | yes |
| RENT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS105_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCAR2_HUMAN | [view interactions] | High throughput | no | yes |
| SUGP2_HUMAN | [view interactions] | High throughput | no | yes |
| ZCCHV_HUMAN | [view interactions] | High throughput | no | yes |
| DHX30_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FIP1_HUMAN | [view interactions] | High throughput | no | yes |
| LARP1_HUMAN | [view interactions] | High throughput | no | yes |
| ILF2_HUMAN | [view interactions] | High throughput | no | yes |
| CPSF1_HUMAN | [view interactions] | High throughput | no | no |
| LG3BP_HUMAN | [view interactions] | High throughput | no | no |
| PURA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RS24_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF2B2_HUMAN | [view interactions] | High throughput | no | yes |
| RS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MATR3_HUMAN | [view interactions] | High throughput | no | yes |
| RS19_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSP74_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| HS74L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NKRF_HUMAN | [view interactions] | High throughput | no | no |
| STAU2_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF2B1_HUMAN | [view interactions] | High throughput | no | no |
| MSI2H_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PUM1_HUMAN | [view interactions] | High throughput | no | yes |
| PABP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELAV2_HUMAN | [view interactions] | High throughput | no | yes |
| YBOX1_HUMAN | [view interactions] | High throughput | no | yes |
| CSTF2_HUMAN | [view interactions] | High throughput | no | yes |
| YBOX3_HUMAN | [view interactions] | High throughput | no | yes |
| PABP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPR_HUMAN | [view interactions] | High throughput | no | yes |
| IF2B3_HUMAN | [view interactions] | High throughput | no | no |
| SYMPK_HUMAN | [view interactions] | High throughput | no | yes |
| MOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGO2_HUMAN | [view interactions] | High throughput | no | yes |
| CNOT7_HUMAN | [view interactions] | High throughput | no | no |
| AGO1_HUMAN | [view interactions] | High throughput | no | no |
| R3HD1_HUMAN | [view interactions] | High throughput | no | no |
| C2D1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RC3H1_HUMAN | [view interactions] | High throughput | no | yes |
| CNOT8_HUMAN | [view interactions] | High throughput | no | yes |
| DCP1A_HUMAN | [view interactions] | High throughput | no | yes |
| LS14B_HUMAN | [view interactions] | High throughput | no | yes |
| EDC3_HUMAN | [view interactions] | High throughput | no | yes |
| TNR6A_HUMAN | [view interactions] | High throughput | no | yes |
| LS14A_HUMAN | [view interactions] | High throughput | no | yes |
| XRN1_HUMAN | [view interactions] | High throughput | no | yes |
| DCP1B_HUMAN | [view interactions] | High throughput | no | yes |
| PATL1_HUMAN | [view interactions] | High throughput | no | yes |
| LARP4_HUMAN | [view interactions] | High throughput | no | yes |
| GGYF2_HUMAN | [view interactions] | High throughput | no | yes |
| EDC4_HUMAN | [view interactions] | High throughput | no | yes |
| RBMS1_HUMAN | [view interactions] | High throughput | no | no |
| 4ET_HUMAN | [view interactions] | High throughput | no | yes |
| PUM2_HUMAN | [view interactions] | High throughput | no | yes |
| UBAP2_HUMAN | [view interactions] | High throughput | no | yes |
| UBP2L_HUMAN | [view interactions] | High throughput | no | yes |
| CNOT1_HUMAN | [view interactions] | High throughput | no | yes |
| MAGD1_HUMAN | [view interactions] | High throughput | no | no |
| YTHD2_HUMAN | [view interactions] | High throughput | no | yes |
| PRC2C_HUMAN | [view interactions] | High throughput | no | yes |
| MARF1_HUMAN | [view interactions] | High throughput | no | yes |
| R3HD2_HUMAN | [view interactions] | High throughput | no | yes |
| SMG5_HUMAN | [view interactions] | High throughput | no | no |
| TNR6B_HUMAN | [view interactions] | High throughput | no | yes |
| CNO11_HUMAN | [view interactions] | High throughput | no | yes |
| CNOT2_HUMAN | [view interactions] | High throughput | no | yes |
| FBSL_HUMAN | [view interactions] | High throughput | no | yes |
| TNR6C_HUMAN | [view interactions] | High throughput | no | no |
| AGO3_HUMAN | [view interactions] | High throughput | no | yes |
| CNO10_HUMAN | [view interactions] | High throughput | no | yes |
| UNK_HUMAN | [view interactions] | High throughput | no | yes |
| YTHD1_HUMAN | [view interactions] | High throughput | no | no |
| K1671_HUMAN | [view interactions] | High throughput | no | yes |
| MCRI2_HUMAN | [view interactions] | High throughput | no | no |
| ATX2_HUMAN | [view interactions] | High throughput | no | yes |
| MYCBP_HUMAN | [view interactions] | High throughput | no | yes |
| ASPP1_HUMAN | [view interactions] | High throughput | no | yes |
| FUBP3_HUMAN | [view interactions] | High throughput | no | yes |
| LAR4B_HUMAN | [view interactions] | High throughput | no | yes |
| CNOT9_HUMAN | [view interactions] | High throughput | no | yes |
| SMG7_HUMAN | [view interactions] | High throughput | no | no |
| SMAP2_HUMAN | [view interactions] | High throughput | no | yes |
| RN214_HUMAN | [view interactions] | High throughput | no | yes |
| ANKH1_HUMAN | [view interactions] | High throughput | no | yes |
| YTHD3_HUMAN | [view interactions] | High throughput | no | no |
| UBP54_HUMAN | [view interactions] | High throughput | no | yes |
| CEP85_HUMAN | [view interactions] | High throughput | no | no |
| PRC2B_HUMAN | [view interactions] | High throughput | no | no |
| PAN3_HUMAN | [view interactions] | High throughput | no | yes |
| TTC31_HUMAN | [view interactions] | High throughput | no | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
| RACK1_HUMAN | [view interactions] | High throughput | no | yes |
| IRAK1_HUMAN | [view interactions] | High throughput | no | yes |
| PRC2A_HUMAN | [view interactions] | High throughput | no | yes |
| HELZ_HUMAN | [view interactions] | High throughput | no | yes |
| OFD1_HUMAN | [view interactions] | High throughput | no | yes |
| GGYF1_HUMAN | [view interactions] | High throughput | no | yes |
| ANR17_HUMAN | [view interactions] | High throughput | no | yes |
| CNOT3_HUMAN | [view interactions] | High throughput | no | yes |
| PFD1_HUMAN | [view interactions] | High throughput | no | yes |
| GRRE1_HUMAN | [view interactions] | High throughput | no | no |
| GTPB1_HUMAN | [view interactions] | High throughput | no | yes |
| CC85C_HUMAN | [view interactions] | High throughput | no | yes |
| MAP12_HUMAN | [view interactions] | High throughput | no | no |
| GBP5_HUMAN | [view interactions] | High throughput | no | no |
| APBA3_HUMAN | [view interactions] | High throughput | no | yes |
| CSTFT_HUMAN | [view interactions] | High throughput | no | yes |
| GAN_HUMAN | [view interactions] | High throughput | no | yes |
| NMD3_HUMAN | [view interactions] | High throughput | no | no |
| PARN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLD2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MESD_HUMAN | [view interactions] | High throughput | no | yes |
| CREB1_HUMAN | [view interactions] | High throughput | no | yes |
| RL39_HUMAN | [view interactions] | High throughput | no | no |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TTP_HUMAN | [view interactions] | High throughput | no | yes |
| I4E1B_HUMAN | [view interactions] | Computational | no | no |
| DDX6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CDK1_HUMAN | [view interactions] | Computational | no | no |
| IF4E_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CCNB2_HUMAN | [view interactions] | Computational | no | yes |
| BOLL_HUMAN | [view interactions] | Computational | no | no |
| AURKA_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PAP1L_HUMAN | [view interactions] | Computational | no | no |
| PLK1_HUMAN | [view interactions] | Computational | no | yes |
| NGDN_HUMAN | [view entry] [view interactions] | Computational | yes | yes |