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CPEB1_HUMAN

GO
G2C
SynaptomeDB

Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5-UUUUUAU-3) within the mRNA 3-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed). In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation . Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses . Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation . Induces the assembly of stress granules in the absence of stress. Required for cell cycle progression, specifically for prophase entry (PubMed). [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in CPEB1_HUMAN
GO:0003723 RNA binding 61.1111 4 yes
GO:0003729 mRNA binding 36.1111 5 yes
GO:0000166 nucleotide binding 25.0000 4 no
GO:0005524 ATP binding 25.0000 5 no
GO:0017076 purine nucleotide binding 25.0000 5 no
GO:0030554 adenyl nucleotide binding 25.0000 6 no
GO:0032555 purine ribonucleotide binding 25.0000 4 no
GO:0032559 adenyl ribonucleotide binding 25.0000 5 no
GO:0035639 purine ribonucleoside triphosphate binding 25.0000 4 no
GO:0043168 anion binding 25.0000 4 no
GO:0003730 mRNA 3-UTR binding 22.2222 6 yes
GO:0043169 cation binding 19.4444 4 yes
GO:0046872 metal ion binding 19.4444 5 yes
GO:0035925 mRNA 3-UTR AU-rich region binding 11.1111 7 yes
GO:0043022 ribosome binding 8.3333 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CPEB1_HUMAN
GO:0009889 regulation of biosynthetic process 58.3333 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 58.3333 5 yes
GO:0031323 regulation of cellular metabolic process 58.3333 4 yes
GO:0031326 regulation of cellular biosynthetic process 58.3333 5 yes
GO:0060255 regulation of macromolecule metabolic process 58.3333 4 yes
GO:0010468 regulation of gene expression 55.5556 6 yes
GO:0048523 negative regulation of cellular process 52.7778 4 yes
GO:0080090 regulation of primary metabolic process 52.7778 4 yes
GO:0048522 positive regulation of cellular process 50.0000 4 no
GO:0009892 negative regulation of metabolic process 47.2222 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 44.4444 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 44.4444 5 no
GO:0051252 regulation of RNA metabolic process 44.4444 5 no
GO:0009890 negative regulation of biosynthetic process 41.6667 5 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 41.6667 6 yes
GO:0031324 negative regulation of cellular metabolic process 41.6667 5 yes
GO:0031327 negative regulation of cellular biosynthetic process 41.6667 6 yes
GO:0090304 nucleic acid metabolic process 41.6667 4 yes
GO:0016070 RNA metabolic process 38.8889 5 yes
GO:0010629 negative regulation of gene expression 36.1111 7 yes
GO:0009893 positive regulation of metabolic process 36.1111 4 no
GO:0010608 post-transcriptional regulation of gene expression 33.3333 7 yes
GO:0009894 regulation of catabolic process 33.3333 4 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0006396 RNA processing 30.5556 6 yes
GO:0051246 regulation of protein metabolic process 27.7778 5 yes
GO:0009891 positive regulation of biosynthetic process 27.7778 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 27.7778 6 no
GO:0031325 positive regulation of cellular metabolic process 27.7778 5 no
GO:0031328 positive regulation of cellular biosynthetic process 27.7778 6 no
GO:0051128 regulation of cellular component organization 27.7778 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0141188 nucleic acid catabolic process 25.0000 5 no
GO:0010646 regulation of cell communication 25.0000 4 no
GO:0022607 cellular component assembly 25.0000 4 no
GO:0006417 regulation of translation 22.2222 6 yes
GO:0016071 mRNA metabolic process 22.2222 6 yes
GO:0006996 organelle organization 22.2222 4 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 22.2222 5 no
GO:0051253 negative regulation of RNA metabolic process 22.2222 6 no
GO:0006412 translation 22.2222 4 no
GO:0009059 macromolecule biosynthetic process 22.2222 4 no
GO:1901566 organonitrogen compound biosynthetic process 22.2222 4 no
GO:0071310 cellular response to organic substance 16.6667 4 yes
GO:0051248 negative regulation of protein metabolic process 13.8889 6 yes
GO:0006397 mRNA processing 11.1111 7 yes
GO:0017148 negative regulation of translation 11.1111 7 yes
GO:1901701 cellular response to oxygen-containing compound 11.1111 4 yes
GO:2000765 regulation of cytoplasmic translation 11.1111 7 yes
GO:0010243 response to organonitrogen compound 8.3333 4 yes
GO:0036293 response to decreased oxygen levels 8.3333 4 yes
GO:0071417 cellular response to organonitrogen compound 8.3333 4 yes
GO:1901699 cellular response to nitrogen compound 8.3333 4 yes
GO:0032868 response to insulin 5.5556 5 yes
GO:0032869 cellular response to insulin stimulus 5.5556 6 yes
GO:0032870 cellular response to hormone stimulus 5.5556 4 yes
GO:0036294 cellular response to decreased oxygen levels 5.5556 5 yes
GO:0043200 response to amino acid 5.5556 4 yes
GO:0043434 response to peptide hormone 5.5556 4 yes
GO:0071229 cellular response to acid chemical 5.5556 4 yes
GO:0071230 cellular response to amino acid stimulus 5.5556 5 yes
GO:0071375 cellular response to peptide hormone stimulus 5.5556 5 yes
GO:0071453 cellular response to oxygen levels 5.5556 4 yes
GO:0071456 cellular response to hypoxia 5.5556 4 yes
GO:2000766 negative regulation of cytoplasmic translation 5.5556 8 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PAPD5_HUMAN [view interactions] Low throughput no no
MSI1H_HUMAN [view interactions] Low throughput no no
CPEB1_HUMAN [view entry] [view interactions] Low throughput yes no
KIF1B_HUMAN [view entry] [view interactions] Low throughput yes yes
MTAP2_HUMAN [view entry] [view interactions] Low throughput yes yes
DLRB1_HUMAN [view entry] [view interactions] Low throughput yes no
APLP1_HUMAN [view interactions] Low throughput no yes
APLP2_HUMAN [view interactions] Low throughput no yes
A4_HUMAN [view entry] [view interactions] Low throughput yes yes
AURKA_HUMAN [view entry] [view interactions] Low throughput yes no
PIN1_HUMAN [view entry] [view interactions] Low throughput yes yes
JUN_HUMAN [view interactions] Low throughput no yes
SYMPK_HUMAN [view interactions] High throughput no yes
IF2B3_HUMAN [view interactions] High throughput no no
HNRPR_HUMAN [view interactions] High throughput no yes
HNRPQ_HUMAN [view entry] [view interactions] High throughput yes yes
PABP1_HUMAN [view entry] [view interactions] High throughput yes yes
YBOX3_HUMAN [view interactions] High throughput no yes
CSTF2_HUMAN [view interactions] High throughput no yes
YBOX1_HUMAN [view interactions] High throughput no yes
ELAV2_HUMAN [view interactions] High throughput no yes
PABP4_HUMAN [view entry] [view interactions] High throughput yes yes
PUM1_HUMAN [view interactions] High throughput no yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
MSI2H_HUMAN [view interactions] High throughput no yes
IF2B1_HUMAN [view interactions] High throughput no no
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
STAU2_HUMAN [view entry] [view interactions] High throughput yes yes
NKRF_HUMAN [view interactions] High throughput no no
HS74L_HUMAN [view entry] [view interactions] High throughput yes no
HNRPL_HUMAN [view interactions] High throughput no yes
HSP74_HUMAN [view entry] [view interactions] High throughput yes yes
RS19_HUMAN [view entry] [view interactions] High throughput yes no
MATR3_HUMAN [view interactions] High throughput no yes
RS10_HUMAN [view entry] [view interactions] High throughput yes yes
RS13_HUMAN [view entry] [view interactions] High throughput yes yes
RS11_HUMAN [view entry] [view interactions] High throughput yes yes
RS15_HUMAN [view entry] [view interactions] High throughput yes yes
IF2B2_HUMAN [view interactions] High throughput no yes
RS24_HUMAN [view entry] [view interactions] High throughput yes yes
PURA_HUMAN [view entry] [view interactions] High throughput yes no
LG3BP_HUMAN [view interactions] High throughput no no
CPSF1_HUMAN [view interactions] High throughput no no
ILF2_HUMAN [view interactions] High throughput no yes
LARP1_HUMAN [view interactions] High throughput no yes
FIP1_HUMAN [view interactions] High throughput no yes
DHX30_HUMAN [view entry] [view interactions] High throughput yes yes
ZCCHV_HUMAN [view interactions] High throughput no yes
SUGP2_HUMAN [view interactions] High throughput no yes
CCAR2_HUMAN [view interactions] High throughput no yes
HS105_HUMAN [view entry] [view interactions] High throughput yes yes
RENT1_HUMAN [view entry] [view interactions] High throughput yes yes
ZFR_HUMAN [view interactions] High throughput no yes
PURB_HUMAN [view entry] [view interactions] High throughput yes no
STRBP_HUMAN [view interactions] High throughput no yes
DDX50_HUMAN [view interactions] High throughput no yes
HNRL1_HUMAN [view interactions] High throughput no yes
XRN2_HUMAN [view interactions] High throughput no yes
DHX36_HUMAN [view interactions] High throughput no yes
MOV10_HUMAN [view interactions] High throughput no no
ZCHC3_HUMAN [view interactions] High throughput no no
ATD3A_HUMAN [view entry] [view interactions] High throughput yes yes
F120A_HUMAN [view interactions] High throughput no yes
MOT2_HUMAN [view entry] [view interactions] High throughput yes yes
CC85C_HUMAN [view interactions] High throughput no yes
GTPB1_HUMAN [view interactions] High throughput no yes
GRRE1_HUMAN [view interactions] High throughput no no
PFD1_HUMAN [view interactions] High throughput no yes
CNOT3_HUMAN [view interactions] High throughput no yes
ANR17_HUMAN [view interactions] High throughput no yes
GGYF1_HUMAN [view interactions] High throughput no yes
OFD1_HUMAN [view interactions] High throughput no yes
HELZ_HUMAN [view interactions] High throughput no yes
PRC2A_HUMAN [view interactions] High throughput no yes
IRAK1_HUMAN [view interactions] High throughput no yes
RACK1_HUMAN [view interactions] High throughput no yes
OTUD4_HUMAN [view interactions] High throughput no yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
R3HD1_HUMAN [view interactions] High throughput no no
TTC31_HUMAN [view interactions] High throughput no yes
PAN3_HUMAN [view interactions] High throughput no yes
PRC2B_HUMAN [view interactions] High throughput no no
RC3H1_HUMAN [view interactions] High throughput no yes
C2D1A_HUMAN [view entry] [view interactions] High throughput yes yes
CEP85_HUMAN [view interactions] High throughput no no
UBP54_HUMAN [view interactions] High throughput no yes
YTHD3_HUMAN [view interactions] High throughput no no
ANKH1_HUMAN [view interactions] High throughput no yes
RN214_HUMAN [view interactions] High throughput no yes
SMAP2_HUMAN [view interactions] High throughput no yes
SMG7_HUMAN [view interactions] High throughput no no
CNOT9_HUMAN [view interactions] High throughput no yes
LAR4B_HUMAN [view interactions] High throughput no yes
FUBP3_HUMAN [view interactions] High throughput no yes
ASPP1_HUMAN [view interactions] High throughput no yes
MYCBP_HUMAN [view interactions] High throughput no yes
ATX2_HUMAN [view interactions] High throughput no yes
MCRI2_HUMAN [view interactions] High throughput no no
K1671_HUMAN [view interactions] High throughput no yes
YTHD1_HUMAN [view interactions] High throughput no no
UNK_HUMAN [view interactions] High throughput no yes
CNO10_HUMAN [view interactions] High throughput no yes
AGO3_HUMAN [view interactions] High throughput no yes
TNR6C_HUMAN [view interactions] High throughput no no
FBSL_HUMAN [view interactions] High throughput no yes
CNOT2_HUMAN [view interactions] High throughput no yes
CNO11_HUMAN [view interactions] High throughput no yes
AGO1_HUMAN [view interactions] High throughput no no
TNR6B_HUMAN [view interactions] High throughput no yes
SMG5_HUMAN [view interactions] High throughput no no
R3HD2_HUMAN [view interactions] High throughput no yes
MARF1_HUMAN [view interactions] High throughput no yes
PRC2C_HUMAN [view interactions] High throughput no yes
YTHD2_HUMAN [view interactions] High throughput no yes
MAGD1_HUMAN [view interactions] High throughput no no
CNOT1_HUMAN [view interactions] High throughput no yes
UBP2L_HUMAN [view interactions] High throughput no yes
UBAP2_HUMAN [view interactions] High throughput no yes
PUM2_HUMAN [view entry] [view interactions] High throughput yes yes
4ET_HUMAN [view interactions] High throughput no yes
RBMS1_HUMAN [view interactions] High throughput no no
EDC4_HUMAN [view interactions] High throughput no yes
GGYF2_HUMAN [view interactions] High throughput no yes
LARP4_HUMAN [view interactions] High throughput no yes
PATL1_HUMAN [view interactions] High throughput no yes
DCP1B_HUMAN [view interactions] High throughput no yes
XRN1_HUMAN [view interactions] High throughput no yes
LS14A_HUMAN [view interactions] High throughput no yes
TNR6A_HUMAN [view interactions] High throughput no yes
EDC3_HUMAN [view interactions] High throughput no yes
LS14B_HUMAN [view interactions] High throughput no yes
DCP1A_HUMAN [view interactions] High throughput no yes
CNOT8_HUMAN [view interactions] High throughput no yes
CNOT7_HUMAN [view interactions] High throughput no no
AGO2_HUMAN [view entry] [view interactions] High throughput yes yes
MAP12_HUMAN [view interactions] High throughput no no
GBP5_HUMAN [view interactions] High throughput no no
APBA3_HUMAN [view interactions] High throughput no yes
CSTFT_HUMAN [view interactions] High throughput no yes
GAN_HUMAN [view interactions] High throughput no yes
NMD3_HUMAN [view interactions] High throughput no no
PARN_HUMAN [view entry] [view interactions] High throughput yes yes
GLD2_HUMAN [view entry] [view interactions] High throughput yes no
MESD_HUMAN [view interactions] High throughput no yes
CREB1_HUMAN [view interactions] High throughput no yes
RL39_HUMAN [view interactions] High throughput no no
FAS_HUMAN [view entry] [view interactions] High throughput yes no
TTP_HUMAN [view interactions] High throughput no yes