CPEB1_HUMAN
Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5-UUUUUAU-3) within the mRNA 3-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed). In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation . Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses . Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation . Induces the assembly of stress granules in the absence of stress. Required for cell cycle progression, specifically for prophase entry (PubMed). [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in CPEB1_HUMAN |
---|---|---|---|---|
GO:0003723 | RNA binding | 61.1111 | 4 | yes |
GO:0003729 | mRNA binding | 36.1111 | 5 | yes |
GO:0000166 | nucleotide binding | 25.0000 | 4 | no |
GO:0005524 | ATP binding | 25.0000 | 5 | no |
GO:0017076 | purine nucleotide binding | 25.0000 | 5 | no |
GO:0030554 | adenyl nucleotide binding | 25.0000 | 6 | no |
GO:0032555 | purine ribonucleotide binding | 25.0000 | 4 | no |
GO:0032559 | adenyl ribonucleotide binding | 25.0000 | 5 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 25.0000 | 4 | no |
GO:0043168 | anion binding | 25.0000 | 4 | no |
GO:0003730 | mRNA 3-UTR binding | 22.2222 | 6 | yes |
GO:0043169 | cation binding | 19.4444 | 4 | yes |
GO:0046872 | metal ion binding | 19.4444 | 5 | yes |
GO:0035925 | mRNA 3-UTR AU-rich region binding | 11.1111 | 7 | yes |
GO:0043022 | ribosome binding | 8.3333 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in CPEB1_HUMAN |
---|---|---|---|---|
GO:0009889 | regulation of biosynthetic process | 58.3333 | 4 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 58.3333 | 5 | yes |
GO:0031323 | regulation of cellular metabolic process | 58.3333 | 4 | yes |
GO:0031326 | regulation of cellular biosynthetic process | 58.3333 | 5 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 58.3333 | 4 | yes |
GO:0010468 | regulation of gene expression | 55.5556 | 6 | yes |
GO:0048523 | negative regulation of cellular process | 52.7778 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 52.7778 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 47.2222 | 4 | yes |
GO:0010605 | negative regulation of macromolecule metabolic process | 44.4444 | 5 | yes |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 44.4444 | 5 | no |
GO:0051252 | regulation of RNA metabolic process | 44.4444 | 5 | no |
GO:0009890 | negative regulation of biosynthetic process | 41.6667 | 5 | yes |
GO:0010558 | negative regulation of macromolecule biosynthetic process | 41.6667 | 6 | yes |
GO:0031324 | negative regulation of cellular metabolic process | 41.6667 | 5 | yes |
GO:0031327 | negative regulation of cellular biosynthetic process | 41.6667 | 6 | yes |
GO:0090304 | nucleic acid metabolic process | 41.6667 | 4 | yes |
GO:0016070 | RNA metabolic process | 38.8889 | 5 | yes |
GO:0010629 | negative regulation of gene expression | 36.1111 | 7 | yes |
GO:0009893 | positive regulation of metabolic process | 36.1111 | 4 | no |
GO:0010608 | post-transcriptional regulation of gene expression | 33.3333 | 7 | yes |
GO:0009894 | regulation of catabolic process | 33.3333 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
GO:0006396 | RNA processing | 30.5556 | 6 | yes |
GO:0051246 | regulation of protein metabolic process | 27.7778 | 5 | yes |
GO:0009891 | positive regulation of biosynthetic process | 27.7778 | 5 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 27.7778 | 6 | no |
GO:0031325 | positive regulation of cellular metabolic process | 27.7778 | 5 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 27.7778 | 6 | no |
GO:0051128 | regulation of cellular component organization | 27.7778 | 4 | no |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
GO:0141188 | nucleic acid catabolic process | 25.0000 | 5 | no |
GO:0010646 | regulation of cell communication | 25.0000 | 4 | no |
GO:0022607 | cellular component assembly | 25.0000 | 4 | no |
GO:0006417 | regulation of translation | 22.2222 | 6 | yes |
GO:0016071 | mRNA metabolic process | 22.2222 | 6 | yes |
GO:0006996 | organelle organization | 22.2222 | 4 | no |
GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 22.2222 | 5 | no |
GO:0051253 | negative regulation of RNA metabolic process | 22.2222 | 6 | no |
GO:0006412 | translation | 22.2222 | 4 | no |
GO:0009059 | macromolecule biosynthetic process | 22.2222 | 4 | no |
GO:1901566 | organonitrogen compound biosynthetic process | 22.2222 | 4 | no |
GO:0071310 | cellular response to organic substance | 16.6667 | 4 | yes |
GO:0051248 | negative regulation of protein metabolic process | 13.8889 | 6 | yes |
GO:0006397 | mRNA processing | 11.1111 | 7 | yes |
GO:0017148 | negative regulation of translation | 11.1111 | 7 | yes |
GO:1901701 | cellular response to oxygen-containing compound | 11.1111 | 4 | yes |
GO:2000765 | regulation of cytoplasmic translation | 11.1111 | 7 | yes |
GO:0010243 | response to organonitrogen compound | 8.3333 | 4 | yes |
GO:0036293 | response to decreased oxygen levels | 8.3333 | 4 | yes |
GO:0071417 | cellular response to organonitrogen compound | 8.3333 | 4 | yes |
GO:1901699 | cellular response to nitrogen compound | 8.3333 | 4 | yes |
GO:0032868 | response to insulin | 5.5556 | 5 | yes |
GO:0032869 | cellular response to insulin stimulus | 5.5556 | 6 | yes |
GO:0032870 | cellular response to hormone stimulus | 5.5556 | 4 | yes |
GO:0036294 | cellular response to decreased oxygen levels | 5.5556 | 5 | yes |
GO:0043200 | response to amino acid | 5.5556 | 4 | yes |
GO:0043434 | response to peptide hormone | 5.5556 | 4 | yes |
GO:0071229 | cellular response to acid chemical | 5.5556 | 4 | yes |
GO:0071230 | cellular response to amino acid stimulus | 5.5556 | 5 | yes |
GO:0071375 | cellular response to peptide hormone stimulus | 5.5556 | 5 | yes |
GO:0071453 | cellular response to oxygen levels | 5.5556 | 4 | yes |
GO:0071456 | cellular response to hypoxia | 5.5556 | 4 | yes |
GO:2000766 | negative regulation of cytoplasmic translation | 5.5556 | 8 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
PAPD5_HUMAN | [view interactions] | Low throughput | no | no |
MSI1H_HUMAN | [view interactions] | Low throughput | no | no |
CPEB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
KIF1B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MTAP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DLRB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
APLP1_HUMAN | [view interactions] | Low throughput | no | yes |
APLP2_HUMAN | [view interactions] | Low throughput | no | yes |
A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AURKA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
PIN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
JUN_HUMAN | [view interactions] | Low throughput | no | yes |
SYMPK_HUMAN | [view interactions] | High throughput | no | yes |
IF2B3_HUMAN | [view interactions] | High throughput | no | no |
HNRPR_HUMAN | [view interactions] | High throughput | no | yes |
HNRPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PABP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
YBOX3_HUMAN | [view interactions] | High throughput | no | yes |
CSTF2_HUMAN | [view interactions] | High throughput | no | yes |
YBOX1_HUMAN | [view interactions] | High throughput | no | yes |
ELAV2_HUMAN | [view interactions] | High throughput | no | yes |
PABP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PUM1_HUMAN | [view interactions] | High throughput | no | yes |
ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MSI2H_HUMAN | [view interactions] | High throughput | no | yes |
IF2B1_HUMAN | [view interactions] | High throughput | no | no |
STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STAU2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NKRF_HUMAN | [view interactions] | High throughput | no | no |
HS74L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
HSP74_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RS19_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MATR3_HUMAN | [view interactions] | High throughput | no | yes |
RS10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RS13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RS11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IF2B2_HUMAN | [view interactions] | High throughput | no | yes |
RS24_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PURA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LG3BP_HUMAN | [view interactions] | High throughput | no | no |
CPSF1_HUMAN | [view interactions] | High throughput | no | no |
ILF2_HUMAN | [view interactions] | High throughput | no | yes |
LARP1_HUMAN | [view interactions] | High throughput | no | yes |
FIP1_HUMAN | [view interactions] | High throughput | no | yes |
DHX30_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZCCHV_HUMAN | [view interactions] | High throughput | no | yes |
SUGP2_HUMAN | [view interactions] | High throughput | no | yes |
CCAR2_HUMAN | [view interactions] | High throughput | no | yes |
HS105_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RENT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZFR_HUMAN | [view interactions] | High throughput | no | yes |
PURB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
STRBP_HUMAN | [view interactions] | High throughput | no | yes |
DDX50_HUMAN | [view interactions] | High throughput | no | yes |
HNRL1_HUMAN | [view interactions] | High throughput | no | yes |
XRN2_HUMAN | [view interactions] | High throughput | no | yes |
DHX36_HUMAN | [view interactions] | High throughput | no | yes |
MOV10_HUMAN | [view interactions] | High throughput | no | no |
ZCHC3_HUMAN | [view interactions] | High throughput | no | no |
ATD3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
F120A_HUMAN | [view interactions] | High throughput | no | yes |
MOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CC85C_HUMAN | [view interactions] | High throughput | no | yes |
GTPB1_HUMAN | [view interactions] | High throughput | no | yes |
GRRE1_HUMAN | [view interactions] | High throughput | no | no |
PFD1_HUMAN | [view interactions] | High throughput | no | yes |
CNOT3_HUMAN | [view interactions] | High throughput | no | yes |
ANR17_HUMAN | [view interactions] | High throughput | no | yes |
GGYF1_HUMAN | [view interactions] | High throughput | no | yes |
OFD1_HUMAN | [view interactions] | High throughput | no | yes |
HELZ_HUMAN | [view interactions] | High throughput | no | yes |
PRC2A_HUMAN | [view interactions] | High throughput | no | yes |
IRAK1_HUMAN | [view interactions] | High throughput | no | yes |
RACK1_HUMAN | [view interactions] | High throughput | no | yes |
OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
R3HD1_HUMAN | [view interactions] | High throughput | no | no |
TTC31_HUMAN | [view interactions] | High throughput | no | yes |
PAN3_HUMAN | [view interactions] | High throughput | no | yes |
PRC2B_HUMAN | [view interactions] | High throughput | no | no |
RC3H1_HUMAN | [view interactions] | High throughput | no | yes |
C2D1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CEP85_HUMAN | [view interactions] | High throughput | no | no |
UBP54_HUMAN | [view interactions] | High throughput | no | yes |
YTHD3_HUMAN | [view interactions] | High throughput | no | no |
ANKH1_HUMAN | [view interactions] | High throughput | no | yes |
RN214_HUMAN | [view interactions] | High throughput | no | yes |
SMAP2_HUMAN | [view interactions] | High throughput | no | yes |
SMG7_HUMAN | [view interactions] | High throughput | no | no |
CNOT9_HUMAN | [view interactions] | High throughput | no | yes |
LAR4B_HUMAN | [view interactions] | High throughput | no | yes |
FUBP3_HUMAN | [view interactions] | High throughput | no | yes |
ASPP1_HUMAN | [view interactions] | High throughput | no | yes |
MYCBP_HUMAN | [view interactions] | High throughput | no | yes |
ATX2_HUMAN | [view interactions] | High throughput | no | yes |
MCRI2_HUMAN | [view interactions] | High throughput | no | no |
K1671_HUMAN | [view interactions] | High throughput | no | yes |
YTHD1_HUMAN | [view interactions] | High throughput | no | no |
UNK_HUMAN | [view interactions] | High throughput | no | yes |
CNO10_HUMAN | [view interactions] | High throughput | no | yes |
AGO3_HUMAN | [view interactions] | High throughput | no | yes |
TNR6C_HUMAN | [view interactions] | High throughput | no | no |
FBSL_HUMAN | [view interactions] | High throughput | no | yes |
CNOT2_HUMAN | [view interactions] | High throughput | no | yes |
CNO11_HUMAN | [view interactions] | High throughput | no | yes |
AGO1_HUMAN | [view interactions] | High throughput | no | no |
TNR6B_HUMAN | [view interactions] | High throughput | no | yes |
SMG5_HUMAN | [view interactions] | High throughput | no | no |
R3HD2_HUMAN | [view interactions] | High throughput | no | yes |
MARF1_HUMAN | [view interactions] | High throughput | no | yes |
PRC2C_HUMAN | [view interactions] | High throughput | no | yes |
YTHD2_HUMAN | [view interactions] | High throughput | no | yes |
MAGD1_HUMAN | [view interactions] | High throughput | no | no |
CNOT1_HUMAN | [view interactions] | High throughput | no | yes |
UBP2L_HUMAN | [view interactions] | High throughput | no | yes |
UBAP2_HUMAN | [view interactions] | High throughput | no | yes |
PUM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
4ET_HUMAN | [view interactions] | High throughput | no | yes |
RBMS1_HUMAN | [view interactions] | High throughput | no | no |
EDC4_HUMAN | [view interactions] | High throughput | no | yes |
GGYF2_HUMAN | [view interactions] | High throughput | no | yes |
LARP4_HUMAN | [view interactions] | High throughput | no | yes |
PATL1_HUMAN | [view interactions] | High throughput | no | yes |
DCP1B_HUMAN | [view interactions] | High throughput | no | yes |
XRN1_HUMAN | [view interactions] | High throughput | no | yes |
LS14A_HUMAN | [view interactions] | High throughput | no | yes |
TNR6A_HUMAN | [view interactions] | High throughput | no | yes |
EDC3_HUMAN | [view interactions] | High throughput | no | yes |
LS14B_HUMAN | [view interactions] | High throughput | no | yes |
DCP1A_HUMAN | [view interactions] | High throughput | no | yes |
CNOT8_HUMAN | [view interactions] | High throughput | no | yes |
CNOT7_HUMAN | [view interactions] | High throughput | no | no |
AGO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MAP12_HUMAN | [view interactions] | High throughput | no | no |
GBP5_HUMAN | [view interactions] | High throughput | no | no |
APBA3_HUMAN | [view interactions] | High throughput | no | yes |
CSTFT_HUMAN | [view interactions] | High throughput | no | yes |
GAN_HUMAN | [view interactions] | High throughput | no | yes |
NMD3_HUMAN | [view interactions] | High throughput | no | no |
PARN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GLD2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MESD_HUMAN | [view interactions] | High throughput | no | yes |
CREB1_HUMAN | [view interactions] | High throughput | no | yes |
RL39_HUMAN | [view interactions] | High throughput | no | no |
FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TTP_HUMAN | [view interactions] | High throughput | no | yes |