Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GLD2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs (PubMed). Does not play a role in replication-dependent histone mRNA degradation (PubMed). Adds a single nucleotide to the 3 end of specific miRNAs, monoadenylation stabilizes and prolongs the activity of some but not all miRNAs (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GLD2_HUMAN
GO:0043169 cation binding 50.0000 4 yes
GO:0046872 metal ion binding 50.0000 5 yes
GO:0003723 RNA binding 50.0000 4 no
GO:0043168 anion binding 37.5000 4 yes
GO:0035091 phosphatidylinositol binding 25.0000 4 no
GO:1901981 phosphatidylinositol phosphate binding 25.0000 5 no
GO:0003729 mRNA binding 25.0000 5 no
GO:0003730 mRNA 3-UTR binding 25.0000 6 no
GO:0019900 kinase binding 25.0000 4 no
GO:0019901 protein kinase binding 25.0000 5 no
GO:0035925 mRNA 3-UTR AU-rich region binding 25.0000 7 no

Biological process

Term Name % Distance from top the of the tree Annotated in GLD2_HUMAN
GO:0009889 regulation of biosynthetic process 87.5000 4 yes
GO:0010468 regulation of gene expression 87.5000 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 87.5000 5 yes
GO:0031323 regulation of cellular metabolic process 87.5000 4 yes
GO:0031326 regulation of cellular biosynthetic process 87.5000 5 yes
GO:0060255 regulation of macromolecule metabolic process 87.5000 4 yes
GO:0080090 regulation of primary metabolic process 87.5000 4 yes
GO:0009892 negative regulation of metabolic process 75.0000 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 75.0000 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 75.0000 5 yes
GO:0031324 negative regulation of cellular metabolic process 75.0000 5 yes
GO:0048523 negative regulation of cellular process 75.0000 4 yes
GO:0051252 regulation of RNA metabolic process 75.0000 5 yes
GO:0009890 negative regulation of biosynthetic process 62.5000 5 yes
GO:0009894 regulation of catabolic process 62.5000 4 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 62.5000 6 yes
GO:0031327 negative regulation of cellular biosynthetic process 62.5000 6 yes
GO:0048522 positive regulation of cellular process 62.5000 4 no
GO:0051246 regulation of protein metabolic process 62.5000 5 no
GO:0009895 negative regulation of catabolic process 50.0000 5 yes
GO:0010629 negative regulation of gene expression 50.0000 7 yes
GO:0016070 RNA metabolic process 50.0000 5 yes
GO:0016071 mRNA metabolic process 50.0000 6 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 50.0000 5 yes
GO:0051253 negative regulation of RNA metabolic process 50.0000 6 yes
GO:0090304 nucleic acid metabolic process 50.0000 4 yes
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 no
GO:0051247 positive regulation of protein metabolic process 50.0000 6 no
GO:0006355 regulation of DNA-templated transcription 37.5000 7 no
GO:0006357 regulation of transcription by RNA polymerase II 37.5000 8 no
GO:0006417 regulation of translation 37.5000 6 no
GO:0006996 organelle organization 37.5000 4 no
GO:0009891 positive regulation of biosynthetic process 37.5000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 37.5000 6 no
GO:0010608 post-transcriptional regulation of gene expression 37.5000 7 no
GO:0010628 positive regulation of gene expression 37.5000 7 no
GO:0023056 positive regulation of signaling 37.5000 4 no
GO:0031325 positive regulation of cellular metabolic process 37.5000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 37.5000 6 no
GO:0043933 protein-containing complex organization 37.5000 4 no
GO:0048585 negative regulation of response to stimulus 37.5000 4 no
GO:0051128 regulation of cellular component organization 37.5000 4 no
GO:0051241 negative regulation of multicellular organismal process 37.5000 4 no
GO:0051248 negative regulation of protein metabolic process 37.5000 6 no
GO:2001141 regulation of RNA biosynthetic process 37.5000 6 no
GO:0022607 cellular component assembly 37.5000 4 no
GO:0097435 supramolecular fiber organization 25.0000 4 no
GO:0008104 protein localization 25.0000 4 no
GO:0015031 protein transport 25.0000 4 no
GO:0071702 organic substance transport 25.0000 4 no
GO:0071705 nitrogen compound transport 25.0000 4 no
GO:0017157 regulation of exocytosis 25.0000 5 no
GO:0045921 positive regulation of exocytosis 25.0000 6 no
GO:0051046 regulation of secretion 25.0000 5 no
GO:0051047 positive regulation of secretion 25.0000 5 no
GO:0051049 regulation of transport 25.0000 4 no
GO:0051050 positive regulation of transport 25.0000 4 no
GO:0060627 regulation of vesicle-mediated transport 25.0000 4 no
GO:1903530 regulation of secretion by cell 25.0000 4 no
GO:1903532 positive regulation of secretion by cell 25.0000 5 no
GO:0009057 macromolecule catabolic process 25.0000 4 yes
GO:1902369 negative regulation of RNA catabolic process 25.0000 6 yes
GO:0006396 RNA processing 25.0000 6 no
GO:0006397 mRNA processing 25.0000 7 no
GO:0000122 negative regulation of transcription by RNA polymerase II 25.0000 9 no
GO:0006508 proteolysis 25.0000 4 no
GO:0006915 apoptotic process 25.0000 4 no
GO:0009966 regulation of signal transduction 25.0000 4 no
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0009968 negative regulation of signal transduction 25.0000 5 no
GO:0010243 response to organonitrogen compound 25.0000 4 no
GO:0010646 regulation of cell communication 25.0000 4 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0010648 negative regulation of cell communication 25.0000 5 no
GO:0023057 negative regulation of signaling 25.0000 4 no
GO:0030097 hemopoiesis 25.0000 4 no
GO:0030162 regulation of proteolysis 25.0000 6 no
GO:0031396 regulation of protein ubiquitination 25.0000 9 no
GO:0031399 regulation of protein modification process 25.0000 6 no
GO:0032006 regulation of TOR signaling 25.0000 6 no
GO:0032008 positive regulation of TOR signaling 25.0000 7 no
GO:0032868 response to insulin 25.0000 5 no
GO:0036211 protein modification process 25.0000 4 no
GO:0042176 regulation of protein catabolic process 25.0000 5 no
GO:0042177 negative regulation of protein catabolic process 25.0000 6 no
GO:0043412 macromolecule modification 25.0000 4 no
GO:0043434 response to peptide hormone 25.0000 4 no
GO:0045727 positive regulation of translation 25.0000 7 no
GO:0045862 positive regulation of proteolysis 25.0000 7 no
GO:0045892 negative regulation of DNA-templated transcription 25.0000 8 no
GO:0045893 positive regulation of DNA-templated transcription 25.0000 8 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0045944 positive regulation of transcription by RNA polymerase II 25.0000 9 no
GO:0048584 positive regulation of response to stimulus 25.0000 4 no
GO:0051056 regulation of small GTPase mediated signal transduction 25.0000 6 no
GO:0051240 positive regulation of multicellular organismal process 25.0000 4 no
GO:0051254 positive regulation of RNA metabolic process 25.0000 6 no
GO:0060341 regulation of cellular localization 25.0000 4 no
GO:0071310 cellular response to organic substance 25.0000 4 no
GO:1901701 cellular response to oxygen-containing compound 25.0000 4 no
GO:1901873 regulation of post-translational protein modification 25.0000 7 no
GO:1902531 regulation of intracellular signal transduction 25.0000 5 no
GO:1902533 positive regulation of intracellular signal transduction 25.0000 6 no
GO:1902679 negative regulation of RNA biosynthetic process 25.0000 7 no
GO:1902680 positive regulation of RNA biosynthetic process 25.0000 7 no
GO:1903320 regulation of protein modification by small protein conjugation or removal 25.0000 8 no
GO:1903432 regulation of TORC1 signaling 25.0000 7 no
GO:1904263 positive regulation of TORC1 signaling 25.0000 8 no
GO:2000036 regulation of stem cell population maintenance 25.0000 4 no
GO:0009059 macromolecule biosynthetic process 25.0000 4 no
GO:0010638 positive regulation of organelle organization 25.0000 6 no
GO:0016050 vesicle organization 25.0000 5 no
GO:0033043 regulation of organelle organization 25.0000 5 no
GO:0043200 response to amino acid 25.0000 4 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 no
GO:0065003 protein-containing complex assembly 25.0000 5 no
GO:0071229 cellular response to acid chemical 25.0000 4 no
GO:0071230 cellular response to amino acid stimulus 25.0000 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MSI1H_HUMAN [view interactions] Low throughput no no
ANXA2_HUMAN [view entry] [view interactions] Low throughput yes no
SOX2_HUMAN [view interactions] High throughput no yes
CACO2_HUMAN [view interactions] High throughput no yes
RBPMS_HUMAN [view interactions] High throughput no no
KRA63_HUMAN [view interactions] High throughput no no
DTX2_HUMAN [view interactions] High throughput no yes
CAPS1_HUMAN [view entry] [view interactions] High throughput yes yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
FOXP3_HUMAN [view interactions] High throughput no no
EED_HUMAN [view interactions] High throughput no yes
BCCIP_HUMAN [view interactions] High throughput no no
NANOG_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
NR2C2_HUMAN [view interactions] High throughput no yes
SYMPK_HUMAN [view interactions] High throughput no yes
CPEB1_HUMAN [view entry] [view interactions] High throughput yes no
TAF1_HUMAN [view interactions] High throughput no yes
ILF3_HUMAN [view interactions] High throughput no yes
RBM4B_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
OGT1_HUMAN [view entry] [view interactions] High throughput yes yes
DCA15_HUMAN [view interactions] High throughput no no