GLD2_HUMAN
Evidence for PS localization
Functions
Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs (PubMed). Does not play a role in replication-dependent histone mRNA degradation (PubMed). Adds a single nucleotide to the 3 end of specific miRNAs, monoadenylation stabilizes and prolongs the activity of some but not all miRNAs (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GLD2_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 62.5000 | 4 | yes |
| GO:0003723 | RNA binding | 62.5000 | 4 | no |
| GO:0019900 | kinase binding | 37.5000 | 4 | no |
| GO:0019901 | protein kinase binding | 37.5000 | 5 | no |
| GO:0003729 | mRNA binding | 37.5000 | 5 | no |
| GO:0003730 | mRNA 3-UTR binding | 37.5000 | 6 | no |
| GO:0035091 | phosphatidylinositol binding | 25.0000 | 4 | no |
| GO:1901981 | phosphatidylinositol phosphate binding | 25.0000 | 5 | no |
| GO:0035925 | mRNA 3-UTR AU-rich region binding | 25.0000 | 7 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GLD2_HUMAN |
|---|---|---|---|---|
| GO:0010468 | regulation of gene expression | 87.5000 | 5 | yes |
| GO:0031323 | regulation of cellular metabolic process | 87.5000 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 87.5000 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 87.5000 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 87.5000 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 75.0000 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 75.0000 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 75.0000 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 75.0000 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 75.0000 | 4 | yes |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 75.0000 | 5 | yes |
| GO:0051252 | regulation of RNA metabolic process | 75.0000 | 5 | yes |
| GO:0048522 | positive regulation of cellular process | 75.0000 | 4 | no |
| GO:0009894 | regulation of catabolic process | 62.5000 | 4 | yes |
| GO:0009895 | negative regulation of catabolic process | 62.5000 | 5 | yes |
| GO:0031329 | regulation of cellular catabolic process | 62.5000 | 5 | yes |
| GO:0031330 | negative regulation of cellular catabolic process | 62.5000 | 6 | yes |
| GO:0009893 | positive regulation of metabolic process | 62.5000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 62.5000 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 62.5000 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 62.5000 | 5 | no |
| GO:0006396 | RNA processing | 50.0000 | 6 | yes |
| GO:0010608 | post-transcriptional regulation of gene expression | 50.0000 | 6 | yes |
| GO:0010629 | negative regulation of gene expression | 50.0000 | 6 | yes |
| GO:0016070 | RNA metabolic process | 50.0000 | 5 | yes |
| GO:0016071 | mRNA metabolic process | 50.0000 | 6 | yes |
| GO:0090304 | nucleic acid metabolic process | 50.0000 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 50.0000 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 50.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 50.0000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 50.0000 | 5 | no |
| GO:0006397 | mRNA processing | 37.5000 | 7 | yes |
| GO:0043489 | RNA stabilization | 37.5000 | 4 | yes |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 37.5000 | 6 | yes |
| GO:0051253 | negative regulation of RNA metabolic process | 37.5000 | 6 | yes |
| GO:1902369 | negative regulation of RNA catabolic process | 37.5000 | 7 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 37.5000 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 37.5000 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 37.5000 | 6 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 37.5000 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 37.5000 | 6 | no |
| GO:0051248 | negative regulation of protein metabolic process | 37.5000 | 6 | no |
| GO:0051049 | regulation of transport | 25.0000 | 4 | no |
| GO:0051050 | positive regulation of transport | 25.0000 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 25.0000 | 4 | no |
| GO:0071702 | organic substance transport | 25.0000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 25.0000 | 4 | no |
| GO:0006417 | regulation of translation | 25.0000 | 6 | no |
| GO:0010628 | positive regulation of gene expression | 25.0000 | 6 | no |
| GO:0022607 | cellular component assembly | 25.0000 | 4 | no |
| GO:0034248 | regulation of cellular amide metabolic process | 25.0000 | 5 | no |
| GO:1903311 | regulation of mRNA metabolic process | 25.0000 | 6 | no |
| GO:2000112 | regulation of cellular macromolecule biosynthetic process | 25.0000 | 6 | no |
| GO:0010638 | positive regulation of organelle organization | 25.0000 | 6 | no |
| GO:0033043 | regulation of organelle organization | 25.0000 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 25.0000 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 25.0000 | 5 | no |
| GO:0000956 | nuclear-transcribed mRNA catabolic process | 25.0000 | 7 | yes |
| GO:0006401 | RNA catabolic process | 25.0000 | 5 | yes |
| GO:0006402 | mRNA catabolic process | 25.0000 | 6 | yes |
| GO:0009057 | macromolecule catabolic process | 25.0000 | 4 | yes |
| GO:0019439 | aromatic compound catabolic process | 25.0000 | 4 | yes |
| GO:0031123 | RNA 3-end processing | 25.0000 | 7 | yes |
| GO:0034655 | nucleobase-containing compound catabolic process | 25.0000 | 4 | yes |
| GO:0044265 | cellular macromolecule catabolic process | 25.0000 | 4 | yes |
| GO:0044270 | cellular nitrogen compound catabolic process | 25.0000 | 4 | yes |
| GO:0046700 | heterocycle catabolic process | 25.0000 | 4 | yes |
| GO:1901361 | organic cyclic compound catabolic process | 25.0000 | 4 | yes |
| GO:0010243 | response to organonitrogen compound | 25.0000 | 4 | no |
| GO:0030162 | regulation of proteolysis | 25.0000 | 6 | no |
| GO:0032868 | response to insulin | 25.0000 | 5 | no |
| GO:0042176 | regulation of protein catabolic process | 25.0000 | 5 | no |
| GO:0042177 | negative regulation of protein catabolic process | 25.0000 | 6 | no |
| GO:0043412 | macromolecule modification | 25.0000 | 4 | no |
| GO:0043434 | response to peptide hormone | 25.0000 | 4 | no |
| GO:0045862 | positive regulation of proteolysis | 25.0000 | 7 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 25.0000 | 4 | no |
| GO:0051254 | positive regulation of RNA metabolic process | 25.0000 | 6 | no |
| GO:1901652 | response to peptide | 25.0000 | 4 | no |
| GO:0008104 | protein localization | 25.0000 | 4 | no |
| GO:0015031 | protein transport | 25.0000 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MSI1H_HUMAN | [view interactions] | Low throughput | no | no |
| ANXA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| CACO2_HUMAN | [view interactions] | High throughput | no | yes |
| RBPMS_HUMAN | [view interactions] | High throughput | no | no |
| DTX2_HUMAN | [view interactions] | High throughput | no | yes |
| CAPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| BCCIP_HUMAN | [view interactions] | High throughput | no | no |
| NANOG_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| SYMPK_HUMAN | [view interactions] | High throughput | no | yes |
| CPEB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TAF1_HUMAN | [view interactions] | High throughput | no | yes |
| ILF3_HUMAN | [view interactions] | High throughput | no | yes |
| RBM4B_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCA15_HUMAN | [view interactions] | High throughput | no | no |
| PARN_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PAP1L_HUMAN | [view interactions] | Computational | no | no |