CAPS1_HUMAN
Evidence for PS localization
Functions
Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CAPS1_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 36.3636 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 22.7273 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 22.7273 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 22.7273 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 22.7273 | 5 | no |
| GO:0019900 | kinase binding | 18.1818 | 4 | yes |
| GO:0019901 | protein kinase binding | 13.6364 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CAPS1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 63.6364 | 4 | yes |
| GO:0051049 | regulation of transport | 50.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 45.4545 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 45.4545 | 4 | no |
| GO:0006996 | organelle organization | 40.9091 | 4 | no |
| GO:0022607 | cellular component assembly | 40.9091 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 40.9091 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 40.9091 | 4 | no |
| GO:0008104 | protein localization | 36.3636 | 4 | yes |
| GO:0051046 | regulation of secretion | 36.3636 | 5 | yes |
| GO:1903530 | regulation of secretion by cell | 36.3636 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 36.3636 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 36.3636 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 36.3636 | 4 | no |
| GO:0015031 | protein transport | 31.8182 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 31.8182 | 4 | yes |
| GO:0051050 | positive regulation of transport | 31.8182 | 4 | yes |
| GO:0071702 | organic substance transport | 31.8182 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 31.8182 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 31.8182 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 31.8182 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 31.8182 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 31.8182 | 4 | no |
| GO:0046903 | secretion | 27.2727 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 27.2727 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 27.2727 | 4 | no |
| GO:0010468 | regulation of gene expression | 27.2727 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 27.2727 | 5 | no |
| GO:0006887 | exocytosis | 22.7273 | 4 | yes |
| GO:0017157 | regulation of exocytosis | 22.7273 | 5 | yes |
| GO:0023061 | signal release | 22.7273 | 4 | yes |
| GO:0051047 | positive regulation of secretion | 22.7273 | 5 | yes |
| GO:0099643 | signal release from synapse | 22.7273 | 5 | yes |
| GO:1903532 | positive regulation of secretion by cell | 22.7273 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 22.7273 | 5 | no |
| GO:0023056 | positive regulation of signaling | 22.7273 | 4 | no |
| GO:0060341 | regulation of cellular localization | 22.7273 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 22.7273 | 4 | no |
| GO:0009894 | regulation of catabolic process | 22.7273 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 22.7273 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 22.7273 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 22.7273 | 5 | no |
| GO:0007010 | cytoskeleton organization | 22.7273 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 22.7273 | 4 | no |
| GO:0010941 | regulation of cell death | 22.7273 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 22.7273 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 22.7273 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 22.7273 | 5 | no |
| GO:0033043 | regulation of organelle organization | 22.7273 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 22.7273 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 22.7273 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 22.7273 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 22.7273 | 5 | no |
| GO:0016079 | synaptic vesicle exocytosis | 18.1818 | 4 | yes |
| GO:0045055 | regulated exocytosis | 18.1818 | 5 | yes |
| GO:0045921 | positive regulation of exocytosis | 18.1818 | 6 | yes |
| GO:0099003 | vesicle-mediated transport in synapse | 18.1818 | 5 | yes |
| GO:0017156 | calcium-ion regulated exocytosis | 13.6364 | 6 | yes |
| GO:1990504 | dense core granule exocytosis | 9.0909 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| STX1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CAPS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SNP25_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| G45IP_HUMAN | [view interactions] | High throughput | no | yes |
| FOXD2_HUMAN | [view interactions] | High throughput | no | no |
| KANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PNMA5_HUMAN | [view interactions] | High throughput | no | yes |
| GPAN1_HUMAN | [view interactions] | High throughput | no | yes |
| ACTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI55_HUMAN | [view interactions] | High throughput | no | no |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| CLIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| PKCB1_HUMAN | [view interactions] | High throughput | no | yes |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKT3_HUMAN | [view interactions] | High throughput | no | yes |
| TAC2N_HUMAN | [view interactions] | High throughput | no | yes |
| MINY2_HUMAN | [view interactions] | High throughput | no | no |
| FYCO1_HUMAN | [view interactions] | High throughput | no | no |
| CEP97_HUMAN | [view interactions] | High throughput | no | yes |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| NUP98_HUMAN | [view interactions] | High throughput | no | no |
| MTMR4_HUMAN | [view interactions] | High throughput | no | no |
| PAN3_HUMAN | [view interactions] | High throughput | no | yes |
| MARF1_HUMAN | [view interactions] | High throughput | no | yes |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BACH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GORAB_HUMAN | [view interactions] | High throughput | no | yes |
| ADDA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCN1_HUMAN | [view interactions] | High throughput | no | no |
| CHM2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FMC1_HUMAN | [view interactions] | High throughput | no | no |
| K1549_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SESD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MSL1_HUMAN | [view interactions] | High throughput | no | yes |
| NEK4_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| TCL1A_HUMAN | [view interactions] | High throughput | no | no |
| LC7L2_HUMAN | [view interactions] | High throughput | no | yes |
| PI51A_HUMAN | [view interactions] | High throughput | no | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EXOC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| SDCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHFL_HUMAN | [view interactions] | High throughput | no | yes |
| F161A_HUMAN | [view interactions] | High throughput | no | no |
| ZN572_HUMAN | [view interactions] | High throughput | no | yes |
| FAM9B_HUMAN | [view interactions] | High throughput | no | no |
| TTL10_HUMAN | [view interactions] | High throughput | no | no |
| CQ067_HUMAN | [view interactions] | High throughput | no | no |
| ZN688_HUMAN | [view interactions] | High throughput | no | yes |
| UBP2_HUMAN | [view interactions] | High throughput | no | yes |
| HXC8_HUMAN | [view interactions] | High throughput | no | no |
| ANS1A_HUMAN | [view interactions] | High throughput | no | yes |
| LNX1_HUMAN | [view interactions] | High throughput | no | yes |
| SC23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH24A_HUMAN | [view interactions] | High throughput | no | no |
| AURKC_HUMAN | [view interactions] | High throughput | no | no |
| CABP5_HUMAN | [view interactions] | High throughput | no | no |
| FANCL_HUMAN | [view interactions] | High throughput | no | yes |
| HXB5_HUMAN | [view interactions] | High throughput | no | no |
| GSE1_HUMAN | [view interactions] | High throughput | no | yes |
| ZC3H1_HUMAN | [view interactions] | High throughput | no | yes |
| CC120_HUMAN | [view interactions] | High throughput | no | no |
| SEN2_HUMAN | [view interactions] | High throughput | no | yes |
| GLD2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRP18_HUMAN | [view interactions] | High throughput | no | yes |
| F90A1_HUMAN | [view interactions] | High throughput | no | no |
| OLIG3_HUMAN | [view interactions] | High throughput | no | no |
| CC185_HUMAN | [view interactions] | High throughput | no | no |
| UN13B_HUMAN | [view interactions] | Computational | no | no |
| RSLAB_HUMAN | [view interactions] | Computational | no | no |