CAPS1_HUMAN
Evidence for PS localization
Functions
Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CAPS1_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 48.1481 | 4 | yes |
| GO:0046872 | metal ion binding | 48.1481 | 5 | yes |
| GO:0043168 | anion binding | 33.3333 | 4 | no |
| GO:0019900 | kinase binding | 22.2222 | 4 | yes |
| GO:0000166 | nucleotide binding | 22.2222 | 4 | no |
| GO:0017076 | purine nucleotide binding | 22.2222 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 22.2222 | 6 | no |
| GO:0032555 | purine ribonucleotide binding | 22.2222 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 22.2222 | 5 | no |
| GO:0019901 | protein kinase binding | 18.5185 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CAPS1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 62.9630 | 4 | yes |
| GO:0010646 | regulation of cell communication | 55.5556 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 51.8519 | 4 | no |
| GO:0051049 | regulation of transport | 44.4444 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 44.4444 | 4 | no |
| GO:0006996 | organelle organization | 40.7407 | 4 | no |
| GO:0022607 | cellular component assembly | 40.7407 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 40.7407 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 40.7407 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 37.0370 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 37.0370 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 37.0370 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 37.0370 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 37.0370 | 4 | no |
| GO:0008104 | protein localization | 33.3333 | 4 | yes |
| GO:0051046 | regulation of secretion | 33.3333 | 5 | yes |
| GO:1903530 | regulation of secretion by cell | 33.3333 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 33.3333 | 5 | no |
| GO:0023056 | positive regulation of signaling | 33.3333 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 33.3333 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 33.3333 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 33.3333 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 33.3333 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 33.3333 | 5 | no |
| GO:0051050 | positive regulation of transport | 29.6296 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 29.6296 | 4 | yes |
| GO:0071702 | organic substance transport | 29.6296 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 29.6296 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 29.6296 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 29.6296 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 29.6296 | 4 | no |
| GO:0010468 | regulation of gene expression | 29.6296 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 29.6296 | 5 | no |
| GO:0017157 | regulation of exocytosis | 25.9259 | 5 | yes |
| GO:0046903 | secretion | 25.9259 | 4 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 25.9259 | 6 | no |
| GO:0050807 | regulation of synapse organization | 25.9259 | 5 | no |
| GO:0060341 | regulation of cellular localization | 25.9259 | 4 | no |
| GO:0036211 | protein modification process | 25.9259 | 4 | no |
| GO:0043412 | macromolecule modification | 25.9259 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 25.9259 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 25.9259 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 25.9259 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.9259 | 5 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 25.9259 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 25.9259 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.9259 | 5 | no |
| GO:0015031 | protein transport | 22.2222 | 4 | yes |
| GO:0023061 | signal release | 22.2222 | 4 | yes |
| GO:0051047 | positive regulation of secretion | 22.2222 | 5 | yes |
| GO:0099643 | signal release from synapse | 22.2222 | 5 | yes |
| GO:1903532 | positive regulation of secretion by cell | 22.2222 | 5 | yes |
| GO:0010038 | response to metal ion | 22.2222 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 22.2222 | 5 | no |
| GO:0009894 | regulation of catabolic process | 22.2222 | 4 | no |
| GO:0061024 | membrane organization | 22.2222 | 4 | no |
| GO:0007268 | chemical synaptic transmission | 22.2222 | 7 | no |
| GO:0032880 | regulation of protein localization | 22.2222 | 5 | no |
| GO:0043933 | protein-containing complex organization | 22.2222 | 4 | no |
| GO:0098916 | anterograde trans-synaptic signaling | 22.2222 | 6 | no |
| GO:0099536 | synaptic signaling | 22.2222 | 4 | no |
| GO:0099537 | trans-synaptic signaling | 22.2222 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 22.2222 | 5 | no |
| GO:0006508 | proteolysis | 22.2222 | 4 | no |
| GO:0009057 | macromolecule catabolic process | 22.2222 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 22.2222 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 22.2222 | 7 | no |
| GO:0043067 | regulation of programmed cell death | 22.2222 | 4 | no |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 22.2222 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 22.2222 | 6 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.2222 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 22.2222 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.2222 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 22.2222 | 4 | no |
| GO:0016079 | synaptic vesicle exocytosis | 18.5185 | 4 | yes |
| GO:0045055 | regulated exocytosis | 18.5185 | 4 | yes |
| GO:0045921 | positive regulation of exocytosis | 18.5185 | 6 | yes |
| GO:0017156 | calcium-ion regulated exocytosis | 14.8148 | 5 | yes |
| GO:0051650 | establishment of vesicle localization | 14.8148 | 4 | yes |
| GO:0032252 | secretory granule localization | 11.1111 | 4 | yes |
| GO:0032253 | dense core granule localization | 11.1111 | 5 | yes |
| GO:1990504 | dense core granule exocytosis | 11.1111 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CAPS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SNP25_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STX1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| K1549_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SESD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MSL1_HUMAN | [view interactions] | High throughput | no | yes |
| NEK4_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| TCL1A_HUMAN | [view interactions] | High throughput | no | no |
| LC7L2_HUMAN | [view interactions] | High throughput | no | yes |
| PI51A_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TTC3_HUMAN | [view interactions] | High throughput | no | yes |
| DSCAM_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| SDCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHFL_HUMAN | [view interactions] | High throughput | no | yes |
| F161A_HUMAN | [view interactions] | High throughput | no | no |
| ZN572_HUMAN | [view interactions] | High throughput | no | yes |
| FAM9B_HUMAN | [view interactions] | High throughput | no | no |
| TTL10_HUMAN | [view interactions] | High throughput | no | no |
| CQ067_HUMAN | [view interactions] | High throughput | no | no |
| ZN688_HUMAN | [view interactions] | High throughput | no | yes |
| UBP2_HUMAN | [view interactions] | High throughput | no | yes |
| HXC8_HUMAN | [view interactions] | High throughput | no | no |
| ANS1A_HUMAN | [view interactions] | High throughput | no | yes |
| LNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH24A_HUMAN | [view interactions] | High throughput | no | no |
| AURKC_HUMAN | [view interactions] | High throughput | no | no |
| CABP5_HUMAN | [view interactions] | High throughput | no | no |
| FANCL_HUMAN | [view interactions] | High throughput | no | yes |
| HXB5_HUMAN | [view interactions] | High throughput | no | no |
| GSE1_HUMAN | [view interactions] | High throughput | no | yes |
| ZC3H1_HUMAN | [view interactions] | High throughput | no | yes |
| CC120_HUMAN | [view interactions] | High throughput | no | no |
| SEN2_HUMAN | [view interactions] | High throughput | no | yes |
| GLD2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRP18_HUMAN | [view interactions] | High throughput | no | yes |
| F90A1_HUMAN | [view interactions] | High throughput | no | no |
| OLIG3_HUMAN | [view interactions] | High throughput | no | no |
| CC185_HUMAN | [view interactions] | High throughput | no | no |
| G45IP_HUMAN | [view interactions] | High throughput | no | yes |
| FOXD2_HUMAN | [view interactions] | High throughput | no | no |
| KANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PNMA5_HUMAN | [view interactions] | High throughput | no | yes |
| GPAN1_HUMAN | [view interactions] | High throughput | no | yes |
| ACTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI55_HUMAN | [view interactions] | High throughput | no | no |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| CLIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| ZMYD8_HUMAN | [view interactions] | High throughput | no | yes |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKT3_HUMAN | [view interactions] | High throughput | no | yes |
| TAC2N_HUMAN | [view interactions] | High throughput | no | yes |
| MINY2_HUMAN | [view interactions] | High throughput | no | no |
| FYCO1_HUMAN | [view interactions] | High throughput | no | no |
| CEP97_HUMAN | [view interactions] | High throughput | no | yes |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| NUP98_HUMAN | [view interactions] | High throughput | no | no |
| MTMR4_HUMAN | [view interactions] | High throughput | no | no |
| PAN3_HUMAN | [view interactions] | High throughput | no | yes |
| MARF1_HUMAN | [view interactions] | High throughput | no | yes |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BACH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GORAB_HUMAN | [view interactions] | High throughput | no | yes |
| ADDA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCN1_HUMAN | [view interactions] | High throughput | no | no |
| CHM2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FMC1_HUMAN | [view interactions] | High throughput | no | no |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |
| PPP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |