KCC2A_HUMAN
Evidence for PS localization
Functions
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission . Regulates dendritic spine development (PubMed). Also regulates the migration of developing neurons (PubMed). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KCC2A_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 30.6011 | 4 | yes |
| GO:0046872 | metal ion binding | 30.0546 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 29.5082 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.7760 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 26.2295 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 25.1366 | 5 | yes |
| GO:0019900 | kinase binding | 24.5902 | 4 | no |
| GO:0005524 | ATP binding | 22.4044 | 5 | yes |
| GO:0019901 | protein kinase binding | 21.8579 | 5 | no |
| GO:0016301 | kinase activity | 15.3005 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 14.7541 | 4 | yes |
| GO:0004674 | protein serine/threonine kinase activity | 10.9290 | 4 | yes |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | 10.9290 | 4 | yes |
| GO:0042803 | protein homodimerization activity | 10.9290 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 9.2896 | 4 | yes |
| GO:0004683 | calmodulin-dependent protein kinase activity | 4.3716 | 5 | yes |
| GO:0035254 | glutamate receptor binding | 4.3716 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KCC2A_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 54.6448 | 4 | yes |
| GO:0010646 | regulation of cell communication | 49.7268 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 46.4481 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 44.8087 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 44.8087 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 44.2623 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 43.7158 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 43.7158 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 40.4372 | 4 | yes |
| GO:0006996 | organelle organization | 35.5191 | 4 | yes |
| GO:0051049 | regulation of transport | 34.9727 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 32.7869 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 32.2404 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 31.6940 | 5 | no |
| GO:0010468 | regulation of gene expression | 31.6940 | 5 | yes |
| GO:0022607 | cellular component assembly | 31.1475 | 4 | no |
| GO:0008104 | protein localization | 29.5082 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 29.5082 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 28.9617 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 28.4153 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 28.4153 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 28.4153 | 5 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.3224 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 26.7760 | 5 | no |
| GO:0031399 | regulation of protein modification process | 26.7760 | 6 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 26.7760 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.7760 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 25.1366 | 4 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 25.1366 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 25.1366 | 5 | no |
| GO:0010941 | regulation of cell death | 25.1366 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 25.1366 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 24.5902 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 24.0437 | 5 | no |
| GO:0033043 | regulation of organelle organization | 24.0437 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 24.0437 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 23.4973 | 6 | no |
| GO:0030030 | cell projection organization | 23.4973 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 23.4973 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 22.9508 | 7 | no |
| GO:0043067 | regulation of programmed cell death | 22.9508 | 5 | yes |
| GO:0043412 | macromolecule modification | 22.9508 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 22.4044 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.4044 | 6 | no |
| GO:0036211 | protein modification process | 22.4044 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 22.4044 | 6 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 21.8579 | 4 | no |
| GO:0071310 | cellular response to organic substance | 21.8579 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 21.8579 | 5 | yes |
| GO:0071702 | organic substance transport | 21.3115 | 4 | no |
| GO:0071705 | nitrogen compound transport | 21.3115 | 4 | no |
| GO:0007010 | cytoskeleton organization | 21.3115 | 5 | no |
| GO:0010243 | response to organonitrogen compound | 21.3115 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 21.3115 | 4 | yes |
| GO:0043269 | regulation of ion transport | 21.3115 | 5 | yes |
| GO:0001932 | regulation of protein phosphorylation | 20.7650 | 7 | no |
| GO:0010647 | positive regulation of cell communication | 20.7650 | 5 | no |
| GO:0023056 | positive regulation of signaling | 20.7650 | 4 | no |
| GO:0051338 | regulation of transferase activity | 20.2186 | 4 | no |
| GO:0009894 | regulation of catabolic process | 20.2186 | 4 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 19.6721 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 19.6721 | 6 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 19.1257 | 6 | yes |
| GO:0051050 | positive regulation of transport | 19.1257 | 4 | yes |
| GO:0051336 | regulation of hydrolase activity | 15.8470 | 4 | yes |
| GO:0016310 | phosphorylation | 14.7541 | 5 | yes |
| GO:0010959 | regulation of metal ion transport | 13.6612 | 6 | yes |
| GO:0051046 | regulation of secretion | 13.6612 | 5 | yes |
| GO:1903530 | regulation of secretion by cell | 13.1148 | 4 | yes |
| GO:0006468 | protein phosphorylation | 13.1148 | 5 | yes |
| GO:0043086 | negative regulation of catalytic activity | 12.5683 | 4 | yes |
| GO:0006811 | ion transport | 12.0219 | 4 | yes |
| GO:0018193 | peptidyl-amino acid modification | 12.0219 | 5 | yes |
| GO:2000145 | regulation of cell motility | 10.9290 | 4 | yes |
| GO:0006812 | cation transport | 10.9290 | 5 | yes |
| GO:0030334 | regulation of cell migration | 10.9290 | 5 | yes |
| GO:0043270 | positive regulation of ion transport | 10.9290 | 5 | yes |
| GO:0010942 | positive regulation of cell death | 10.3825 | 5 | yes |
| GO:0030001 | metal ion transport | 9.8361 | 6 | yes |
| GO:0051924 | regulation of calcium ion transport | 9.8361 | 7 | yes |
| GO:0061024 | membrane organization | 8.1967 | 4 | yes |
| GO:0018209 | peptidyl-serine modification | 8.1967 | 6 | yes |
| GO:0043065 | positive regulation of apoptotic process | 8.1967 | 7 | yes |
| GO:0043068 | positive regulation of programmed cell death | 8.1967 | 6 | yes |
| GO:0018105 | peptidyl-serine phosphorylation | 7.6503 | 6 | yes |
| GO:0048168 | regulation of neuronal synaptic plasticity | 7.6503 | 4 | yes |
| GO:0007005 | mitochondrion organization | 7.1038 | 5 | yes |
| GO:0046777 | protein autophosphorylation | 7.1038 | 6 | yes |
| GO:0046928 | regulation of neurotransmitter secretion | 7.1038 | 4 | yes |
| GO:0051588 | regulation of neurotransmitter transport | 7.1038 | 5 | yes |
| GO:0008277 | regulation of G protein-coupled receptor signaling pathway | 6.0109 | 5 | yes |
| GO:0051346 | negative regulation of hydrolase activity | 5.4645 | 5 | yes |
| GO:0051928 | positive regulation of calcium ion transport | 5.4645 | 6 | yes |
| GO:0006816 | calcium ion transport | 4.9180 | 7 | yes |
| GO:0018107 | peptidyl-threonine phosphorylation | 4.9180 | 6 | yes |
| GO:0018210 | peptidyl-threonine modification | 4.9180 | 6 | yes |
| GO:0051091 | positive regulation of DNA-binding transcription factor activity | 3.8251 | 4 | yes |
| GO:2001222 | regulation of neuron migration | 3.2787 | 6 | yes |
| GO:0007006 | mitochondrial membrane organization | 3.2787 | 5 | yes |
| GO:0010660 | regulation of muscle cell apoptotic process | 3.2787 | 7 | yes |
| GO:0044772 | mitotic cell cycle phase transition | 3.2787 | 4 | yes |
| GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 3.2787 | 5 | yes |
| GO:0008637 | apoptotic mitochondrial changes | 2.1858 | 6 | yes |
| GO:0010661 | positive regulation of muscle cell apoptotic process | 1.6393 | 8 | yes |
| GO:0010662 | regulation of striated muscle cell apoptotic process | 1.6393 | 8 | yes |
| GO:0010663 | positive regulation of striated muscle cell apoptotic process | 1.6393 | 9 | yes |
| GO:0010665 | regulation of cardiac muscle cell apoptotic process | 1.6393 | 9 | yes |
| GO:0010666 | positive regulation of cardiac muscle cell apoptotic process | 1.6393 | 10 | yes |
| GO:0038166 | angiotensin-activated signaling pathway | 1.6393 | 4 | yes |
| GO:0046902 | regulation of mitochondrial membrane permeability | 1.6393 | 4 | yes |
| GO:1902108 | regulation of mitochondrial membrane permeability involved in apoptotic process | 1.0929 | 5 | yes |
| GO:1990443 | peptidyl-threonine autophosphorylation | 1.0929 | 7 | yes |
| GO:2000124 | regulation of endocannabinoid signaling pathway | 1.0929 | 6 | yes |
| GO:0000082 | G1/S transition of mitotic cell cycle | 1.0929 | 5 | yes |
| GO:0044843 | cell cycle G1/S phase transition | 1.0929 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in KCC2A_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 4.3716 | 3 | no |
| DOID:0050700 | cardiomyopathy | 2.1858 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 2.1858 | 5 | no |
| DOID:114 | heart disease | 2.1858 | 3 | no |
| DOID:936 | brain disease | 1.6393 | 4 | no |
| DOID:2843 | long QT syndrome | 1.6393 | 6 | no |
| DOID:1289 | neurodegenerative disease | 1.6393 | 4 | no |
| DOID:1826 | epilepsy | 1.0929 | 5 | no |
| DOID:10273 | heart conduction disease | 1.0929 | 4 | no |
| DOID:0111198 | autosomal dominant distal hereditary motor neuronopathy | 1.0929 | 7 | no |
| DOID:12377 | spinal muscular atrophy | 1.0929 | 6 | no |
| DOID:231 | motor neuron disease | 1.0929 | 5 | no |
| DOID:574 | peripheral nervous system disease | 1.0929 | 3 | no |
| DOID:870 | neuropathy | 1.0929 | 4 | no |
| DOID:2476 | hereditary spastic paraplegia | 1.0929 | 5 | no |
| DOID:607 | paraplegia | 1.0929 | 4 | no |
| DOID:0050701 | electroclinical syndrome | 1.0929 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CD5R2_HUMAN | [view interactions] | Low throughput | no | no |
| ACTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRS8_HUMAN | [view interactions] | Low throughput | no | yes |
| CAC1A_HUMAN | [view interactions] | Low throughput | no | no |
| KCC2B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TAU_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMDE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACTN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LRRC7_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ACM4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CXD2_HUMAN | [view interactions] | Low throughput | no | no |
| CALM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NMDZ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CAN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CDK5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RHG32_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| GRIA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KCC2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RIMS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ZN363_HUMAN | [view interactions] | Low throughput | no | yes |
| ATF1_HUMAN | [view interactions] | Low throughput | no | yes |
| CREB1_HUMAN | [view interactions] | Low throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PSA2_HUMAN | [view interactions] | Low throughput | no | yes |
| GYS1_HUMAN | [view interactions] | Low throughput | no | yes |
| LBR_HUMAN | [view interactions] | Low throughput | no | yes |
| ITA2B_HUMAN | [view interactions] | Low throughput | no | no |
| PTTG1_HUMAN | [view interactions] | Low throughput | no | no |
| ACHA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MPDZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IQEC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TIAM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRS6B_HUMAN | [view interactions] | Low throughput | no | yes |
| PRS4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRS7_HUMAN | [view interactions] | Low throughput | no | yes |
| ACM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PPM1F_HUMAN | [view interactions] | Low throughput | no | yes |
| GRM5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CACB2_HUMAN | [view interactions] | Low throughput | no | yes |
| CD5R1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ACTN4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GRM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HDAC5_HUMAN | [view interactions] | Low throughput | no | yes |
| GIT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PLCG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NOS3_HUMAN | [view interactions] | Low throughput | no | no |
| KCNC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SC6A3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RD23A_HUMAN | [view interactions] | Low throughput | no | yes |
| FKBP8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TANC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRM4_HUMAN | [view interactions] | Low throughput | no | no |
| GRM7_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CYLD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCNJ2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTPRR_HUMAN | [view interactions] | Low throughput | no | yes |
| BASP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RGS14_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| REM2_HUMAN | [view interactions] | Low throughput | no | no |
| ARHG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASNS_HUMAN | [view interactions] | High throughput | no | yes |
| ASGL1_HUMAN | [view interactions] | High throughput | no | yes |
| AT1A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAG6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRSK1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAMKV_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAZA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSKI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCLK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DGKB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DGKG_HUMAN | [view interactions] | High throughput | no | no |
| DLGP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNM1L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EHD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IF5A1_HUMAN | [view interactions] | High throughput | no | yes |
| E41L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSTM1_HUMAN | [view interactions] | High throughput | no | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS105_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HYOU1_HUMAN | [view interactions] | High throughput | no | yes |
| IMPCT_HUMAN | [view interactions] | High throughput | no | yes |
| KCC2D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INP4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZMYM1_HUMAN | [view interactions] | High throughput | no | no |
| IQEC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCC2G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IP3KA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FUBP2_HUMAN | [view interactions] | High throughput | no | yes |
| DBNL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MADD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF2B3_HUMAN | [view interactions] | High throughput | no | no |
| MAP1S_HUMAN | [view interactions] | High throughput | no | no |
| SC16A_HUMAN | [view interactions] | High throughput | no | yes |
| MP2K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL1D1_HUMAN | [view interactions] | High throughput | no | yes |
| MAP6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HEMO_HUMAN | [view interactions] | High throughput | no | no |
| PHOCN_HUMAN | [view interactions] | High throughput | no | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NRBF2_HUMAN | [view interactions] | High throughput | no | yes |
| H12_HUMAN | [view interactions] | High throughput | no | yes |
| PCLO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H13_HUMAN | [view interactions] | High throughput | no | no |
| PDE2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGA1_HUMAN | [view interactions] | High throughput | no | yes |
| PDE4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBRL_HUMAN | [view interactions] | High throughput | no | yes |
| PDE4D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL39_HUMAN | [view interactions] | High throughput | no | no |
| PHAR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| R39L5_HUMAN | [view interactions] | High throughput | no | no |
| PI4KA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PI51C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H31_HUMAN | [view interactions] | High throughput | no | yes |
| PPM1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H33_HUMAN | [view interactions] | High throughput | no | yes |
| KPCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H31T_HUMAN | [view interactions] | High throughput | no | yes |
| KPCG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H32_HUMAN | [view interactions] | High throughput | no | yes |
| PRS6A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H3C_HUMAN | [view interactions] | High throughput | no | yes |
| RAB8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| RPGF2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DDX21_HUMAN | [view interactions] | High throughput | no | yes |
| RGRF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G3BP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHEB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ROCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RS20_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAM14_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| H14_HUMAN | [view interactions] | High throughput | no | yes |
| SEPT9_HUMAN | [view interactions] | High throughput | no | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STK39_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| STRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DSG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TCPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H90B2_HUMAN | [view interactions] | High throughput | no | no |
| TRIM3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| H2A1C_HUMAN | [view interactions] | High throughput | no | yes |
| UBL4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2A1B_HUMAN | [view interactions] | High throughput | no | yes |
| UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2A3_HUMAN | [view interactions] | High throughput | no | yes |
| WDR7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZWINT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| SBP2L_HUMAN | [view interactions] | High throughput | no | yes |
| HNRL2_HUMAN | [view interactions] | High throughput | no | yes |
| FND3B_HUMAN | [view interactions] | High throughput | no | no |
| TAB1_HUMAN | [view interactions] | High throughput | no | yes |
| RD23B_HUMAN | [view interactions] | High throughput | no | yes |
| AINX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELP3_HUMAN | [view interactions] | High throughput | no | no |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| YES_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SENP5_HUMAN | [view interactions] | High throughput | no | no |
| CLK1_HUMAN | [view interactions] | High throughput | no | yes |
| M3K7_HUMAN | [view interactions] | High throughput | no | yes |
| DZIP1_HUMAN | [view interactions] | High throughput | no | yes |
| PNKP_HUMAN | [view interactions] | High throughput | no | yes |
| CBY1_HUMAN | [view interactions] | High throughput | no | no |
| DUS11_HUMAN | [view interactions] | High throughput | no | no |
| SNRK_HUMAN | [view interactions] | High throughput | no | yes |
| CBPC5_HUMAN | [view interactions] | High throughput | no | no |
| NUP88_HUMAN | [view interactions] | High throughput | no | yes |
| THA11_HUMAN | [view interactions] | High throughput | no | yes |
| ASTRA_HUMAN | [view interactions] | High throughput | no | no |
| XRN1_HUMAN | [view interactions] | High throughput | no | yes |
| UBP7_HUMAN | [view interactions] | High throughput | no | yes |
| PUSL1_HUMAN | [view interactions] | High throughput | no | yes |
| CKAP2_HUMAN | [view interactions] | High throughput | no | yes |
| PATL1_HUMAN | [view interactions] | High throughput | no | yes |
| RLGPB_HUMAN | [view interactions] | High throughput | no | yes |
| MAP7_HUMAN | [view interactions] | High throughput | no | yes |
| CK2N1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMHD1_HUMAN | [view interactions] | High throughput | no | yes |
| MLF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBMS2_HUMAN | [view interactions] | High throughput | no | yes |
| ITPR3_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| ITPR2_HUMAN | [view interactions] | High throughput | no | yes |
| RUSD4_HUMAN | [view interactions] | High throughput | no | yes |
| MAP11_HUMAN | [view interactions] | High throughput | no | yes |
| RAB21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUP62_HUMAN | [view interactions] | High throughput | no | yes |
| EST1A_HUMAN | [view interactions] | High throughput | no | yes |
| NU214_HUMAN | [view interactions] | High throughput | no | no |
| KANL3_HUMAN | [view interactions] | High throughput | no | yes |
| ITPI2_HUMAN | [view interactions] | High throughput | no | yes |
| LIN54_HUMAN | [view interactions] | High throughput | no | yes |
| PDE4A_HUMAN | [view interactions] | High throughput | no | no |
| F120A_HUMAN | [view interactions] | High throughput | no | yes |
| TRI27_HUMAN | [view interactions] | High throughput | no | yes |
| ARG39_HUMAN | [view interactions] | High throughput | no | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GTSE1_HUMAN | [view interactions] | High throughput | no | no |
| DTL_HUMAN | [view interactions] | High throughput | no | no |
| IF4G2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF4G3_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOK_HUMAN | [view interactions] | High throughput | no | no |
| DLG3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NIT1_HUMAN | [view interactions] | High throughput | no | yes |
| CHMP5_HUMAN | [view interactions] | High throughput | no | yes |
| PKP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM14_HUMAN | [view interactions] | High throughput | no | yes |
| LYPA1_HUMAN | [view interactions] | High throughput | no | yes |
| PLD2_HUMAN | [view interactions] | High throughput | no | yes |
| WDR76_HUMAN | [view interactions] | High throughput | no | no |
| CNKR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EMSY_HUMAN | [view interactions] | High throughput | no | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PMFBP_HUMAN | [view interactions] | High throughput | no | yes |
| CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMCR8_HUMAN | [view interactions] | High throughput | no | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K0895_HUMAN | [view interactions] | High throughput | no | no |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PI51A_HUMAN | [view interactions] | High throughput | no | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANGE2_HUMAN | [view interactions] | High throughput | no | yes |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| MTG1_HUMAN | [view interactions] | High throughput | no | yes |
| HOME1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYH14_HUMAN | [view interactions] | High throughput | no | no |
| MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ELP2_HUMAN | [view interactions] | High throughput | no | yes |
| NCKP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELP1_HUMAN | [view interactions] | High throughput | no | yes |
| PEX5R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LACTB_HUMAN | [view interactions] | High throughput | no | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| VATL_HUMAN | [view interactions] | High throughput | no | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MECP2_HUMAN | [view interactions] | High throughput | no | yes |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DMPK_HUMAN | [view interactions] | High throughput | no | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AOC3_HUMAN | [view interactions] | High throughput | no | no |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EHMT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KALRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| SCN5A_HUMAN | [view interactions] | High throughput | no | no |
| RM11_HUMAN | [view interactions] | High throughput | no | yes |
| RHXF2_HUMAN | [view interactions] | High throughput | no | no |
| GLBL2_HUMAN | [view interactions] | High throughput | no | no |
| TEX37_HUMAN | [view interactions] | High throughput | no | no |
| KR151_HUMAN | [view interactions] | High throughput | no | no |
| SYVC_HUMAN | [view interactions] | High throughput | no | yes |
| KR231_HUMAN | [view interactions] | High throughput | no | no |
| KR193_HUMAN | [view interactions] | High throughput | no | no |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K2C75_HUMAN | [view interactions] | High throughput | no | no |
| HES1_HUMAN | [view interactions] | High throughput | no | no |
| K22O_HUMAN | [view interactions] | High throughput | no | no |
| HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CA094_HUMAN | [view interactions] | High throughput | no | no |
| GNAO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KRA81_HUMAN | [view interactions] | High throughput | no | no |
| ARI5A_HUMAN | [view interactions] | High throughput | no | yes |
| KRA61_HUMAN | [view interactions] | High throughput | no | no |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LENG8_HUMAN | [view interactions] | High throughput | no | yes |
| NTAQ1_HUMAN | [view interactions] | High throughput | no | yes |
| RBPS2_HUMAN | [view interactions] | High throughput | no | no |
| TSR2_HUMAN | [view interactions] | High throughput | no | yes |
| AP2D_HUMAN | [view interactions] | High throughput | no | no |
| KRA62_HUMAN | [view interactions] | High throughput | no | no |
| TAB2_HUMAN | [view interactions] | High throughput | no | yes |
| KR195_HUMAN | [view interactions] | High throughput | no | no |
| RBM47_HUMAN | [view interactions] | High throughput | no | yes |
| DAZP2_HUMAN | [view interactions] | High throughput | no | no |
| TTC5_HUMAN | [view interactions] | High throughput | no | yes |
| SUOX_HUMAN | [view interactions] | High throughput | no | no |
| HYAL3_HUMAN | [view interactions] | High throughput | no | no |
| KR197_HUMAN | [view interactions] | High throughput | no | no |
| ACTS_HUMAN | [view interactions] | High throughput | no | no |
| AKT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT1A3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UT14A_HUMAN | [view interactions] | High throughput | no | yes |
| PLPP1_HUMAN | [view interactions] | High throughput | no | no |
| PNPH_HUMAN | [view interactions] | High throughput | no | no |
| SMAD3_HUMAN | [view interactions] | High throughput | no | yes |
| CBS_HUMAN | [view interactions] | High throughput | no | yes |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2K_HUMAN | [view interactions] | High throughput | no | yes |
| PECA1_HUMAN | [view interactions] | High throughput | no | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S100B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSBP2_HUMAN | [view interactions] | High throughput | no | yes |
| NBEL2_HUMAN | [view interactions] | High throughput | no | no |
| FAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2F6_HUMAN | [view interactions] | High throughput | no | no |
| SMAD2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| TRI55_HUMAN | [view interactions] | High throughput | no | no |
| ARL3_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| LASP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBT32_HUMAN | [view interactions] | High throughput | no | yes |
| F168A_HUMAN | [view interactions] | High throughput | no | yes |
| RFOX2_HUMAN | [view interactions] | High throughput | no | yes |
| SOX5_HUMAN | [view interactions] | High throughput | no | no |
| TIAR_HUMAN | [view interactions] | High throughput | no | no |
| F168B_HUMAN | [view interactions] | High throughput | no | yes |
| RBPMS_HUMAN | [view interactions] | High throughput | no | no |
| RALYL_HUMAN | [view interactions] | High throughput | no | yes |
| KR221_HUMAN | [view interactions] | High throughput | no | no |
| TCAF1_HUMAN | [view interactions] | High throughput | no | no |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARMC1_HUMAN | [view interactions] | High throughput | no | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| RRP7A_HUMAN | [view interactions] | High throughput | no | yes |
| BOREA_HUMAN | [view interactions] | High throughput | no | yes |
| DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| OSTM1_HUMAN | [view interactions] | High throughput | no | yes |
| INADL_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TISD_HUMAN | [view interactions] | High throughput | no | no |
| ACK1_HUMAN | [view interactions] | High throughput | no | yes |
| PPAC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADDB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG44_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |