Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AT1A3_HUMAN

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in AT1A3_HUMAN
GO:0043169 cation binding 30.8824 4 yes
GO:0008324 monoatomic cation transmembrane transporter activity 29.4118 4 yes
GO:0043168 anion binding 29.4118 4 yes
GO:0000166 nucleotide binding 26.4706 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 26.4706 4 yes
GO:0046872 metal ion binding 26.4706 5 yes
GO:0017076 purine nucleotide binding 25.0000 5 yes
GO:0032555 purine ribonucleotide binding 25.0000 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 23.5294 4 yes
GO:0030554 adenyl nucleotide binding 20.5882 6 yes
GO:0032559 adenyl ribonucleotide binding 20.5882 5 yes
GO:0005524 ATP binding 19.1176 5 yes
GO:0046873 metal ion transmembrane transporter activity 19.1176 5 yes
GO:0016462 pyrophosphatase activity 16.1765 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 16.1765 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 16.1765 6 yes
GO:0022853 active monoatomic ion transmembrane transporter activity 16.1765 4 yes
GO:0015081 sodium ion transmembrane transporter activity 11.7647 6 yes
GO:0015399 primary active transmembrane transporter activity 11.7647 4 yes
GO:0016887 ATP hydrolysis activity 11.7647 7 yes
GO:0015079 potassium ion transmembrane transporter activity 10.2941 6 yes
GO:0005391 P-type sodium:potassium-exchanging transporter activity 7.3529 5 yes
GO:0008554 P-type sodium transporter activity 7.3529 4 yes
GO:0008556 P-type potassium transmembrane transporter activity 7.3529 4 yes
GO:0015662 P-type ion transporter activity 7.3529 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in AT1A3_HUMAN
GO:0048522 positive regulation of cellular process 50.0000 4 no
GO:0051049 regulation of transport 45.5882 4 no
GO:0010646 regulation of cell communication 44.1176 4 no
GO:0051128 regulation of cellular component organization 41.1765 4 no
GO:0048523 negative regulation of cellular process 39.7059 4 no
GO:0031323 regulation of cellular metabolic process 38.2353 4 no
GO:0006811 monoatomic ion transport 33.8235 4 yes
GO:0080090 regulation of primary metabolic process 32.3529 4 no
GO:0060255 regulation of macromolecule metabolic process 32.3529 4 no
GO:0008104 protein localization 30.8824 4 no
GO:0022607 cellular component assembly 30.8824 4 no
GO:0071702 organic substance transport 30.8824 4 no
GO:0006996 organelle organization 29.4118 4 no
GO:0006812 monoatomic cation transport 27.9412 5 yes
GO:0050804 modulation of chemical synaptic transmission 27.9412 5 no
GO:0099177 regulation of trans-synaptic signaling 27.9412 4 no
GO:0009893 positive regulation of metabolic process 27.9412 4 no
GO:0098657 import into cell 26.4706 4 yes
GO:0071705 nitrogen compound transport 26.4706 4 no
GO:0009889 regulation of biosynthetic process 26.4706 4 no
GO:0031326 regulation of cellular biosynthetic process 26.4706 5 no
GO:0030001 metal ion transport 25.0000 6 yes
GO:0060341 regulation of cellular localization 25.0000 4 no
GO:0009966 regulation of signal transduction 25.0000 4 no
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0006873 intracellular monoatomic ion homeostasis 23.5294 4 yes
GO:0030003 intracellular monoatomic cation homeostasis 23.5294 5 yes
GO:0055080 monoatomic cation homeostasis 23.5294 4 yes
GO:0098655 monoatomic cation transmembrane transport 23.5294 4 yes
GO:0098662 inorganic cation transmembrane transport 23.5294 4 yes
GO:0034762 regulation of transmembrane transport 23.5294 4 no
GO:0043269 regulation of monoatomic ion transport 23.5294 5 no
GO:0043933 protein-containing complex organization 23.5294 4 no
GO:0010604 positive regulation of macromolecule metabolic process 23.5294 5 no
GO:0033043 regulation of organelle organization 23.5294 5 no
GO:0071310 cellular response to organic substance 22.0588 4 yes
GO:0015031 protein transport 22.0588 4 no
GO:0051050 positive regulation of transport 22.0588 4 no
GO:0010468 regulation of gene expression 22.0588 6 no
GO:0010243 response to organonitrogen compound 20.5882 4 yes
GO:0014070 response to organic cyclic compound 20.5882 4 yes
GO:0032880 regulation of protein localization 20.5882 5 no
GO:0031325 positive regulation of cellular metabolic process 20.5882 5 no
GO:0044087 regulation of cellular component biogenesis 20.5882 4 no
GO:0051240 positive regulation of multicellular organismal process 20.5882 4 no
GO:1901701 cellular response to oxygen-containing compound 16.1765 4 yes
GO:0030030 cell projection organization 14.7059 4 yes
GO:0006814 sodium ion transport 13.2353 7 yes
GO:0033993 response to lipid 13.2353 4 yes
GO:0098659 inorganic cation import across plasma membrane 13.2353 5 yes
GO:0099587 inorganic ion import across plasma membrane 13.2353 4 yes
GO:0120036 plasma membrane bounded cell projection organization 13.2353 5 yes
GO:0006813 potassium ion transport 11.7647 7 yes
GO:0035725 sodium ion transmembrane transport 11.7647 5 yes
GO:0071417 cellular response to organonitrogen compound 11.7647 4 yes
GO:0071805 potassium ion transmembrane transport 11.7647 5 yes
GO:1901699 cellular response to nitrogen compound 11.7647 4 yes
GO:0006883 intracellular sodium ion homeostasis 10.2941 5 yes
GO:0030007 intracellular potassium ion homeostasis 10.2941 5 yes
GO:0036376 sodium ion export across plasma membrane 10.2941 4 yes
GO:0055075 potassium ion homeostasis 10.2941 4 yes
GO:0055078 sodium ion homeostasis 10.2941 4 yes
GO:0086064 cell communication by electrical coupling involved in cardiac conduction 10.2941 4 yes
GO:1902600 proton transmembrane transport 10.2941 5 yes
GO:0048545 response to steroid hormone 8.8235 4 yes
GO:0071407 cellular response to organic cyclic compound 8.8235 5 yes
GO:1990573 potassium ion import across plasma membrane 8.8235 6 yes
GO:0032870 cellular response to hormone stimulus 7.3529 4 yes
GO:0071396 cellular response to lipid 7.3529 5 yes
GO:0071383 cellular response to steroid hormone stimulus 4.4118 5 yes
GO:0106027 neuron projection organization 4.4118 6 yes
GO:1903416 response to glycoside 4.4118 4 yes
GO:1904645 response to amyloid-beta 4.4118 4 yes
GO:1904646 cellular response to amyloid-beta 4.4118 5 yes
GO:1990535 neuron projection maintenance 4.4118 7 yes
GO:0060075 regulation of resting membrane potential 2.9412 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
FXYD6_HUMAN [view entry] [view interactions] Low throughput yes yes
LRAD3_HUMAN [view interactions] Low throughput no yes
XLRS1_HUMAN [view interactions] Low throughput no no
SARM1_HUMAN [view entry] [view interactions] Low throughput yes yes
GPNMB_HUMAN [view interactions] Low throughput no no
AT1B1_HUMAN [view entry] [view interactions] Low throughput yes no
GPR12_HUMAN [view interactions] High throughput no no
CXL16_HUMAN [view interactions] High throughput no no
P2RX5_HUMAN [view interactions] High throughput no no
ALG8_HUMAN [view interactions] High throughput no yes
SSRB_HUMAN [view interactions] High throughput no no
AT1A1_HUMAN [view entry] [view interactions] High throughput yes no
AT1A2_HUMAN [view entry] [view interactions] High throughput yes yes
C5AR2_HUMAN [view interactions] High throughput no yes
PMEL_HUMAN [view interactions] High throughput no no
ACM4_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA4_HUMAN [view entry] [view interactions] High throughput yes yes
ACM3_HUMAN [view entry] [view interactions] High throughput yes yes
NDRG3_HUMAN [view interactions] High throughput no yes
CLC2D_HUMAN [view interactions] High throughput no yes
SIA8C_HUMAN [view interactions] High throughput no yes
OPALI_HUMAN [view interactions] High throughput no yes
SNX14_HUMAN [view entry] [view interactions] High throughput yes yes
SEC62_HUMAN [view interactions] High throughput no yes
NKG2A_HUMAN [view interactions] High throughput no no
ICAM2_HUMAN [view interactions] High throughput no no
VIPR2_HUMAN [view interactions] High throughput no no
TMM9B_HUMAN [view interactions] High throughput no yes
HS2ST_HUMAN [view interactions] High throughput no yes
DRB5_HUMAN [view interactions] High throughput no no
ENTP2_HUMAN [view interactions] High throughput no yes
TNFL8_HUMAN [view interactions] High throughput no no
F162A_HUMAN [view interactions] High throughput no yes
TM231_HUMAN [view interactions] High throughput no yes
THTPA_HUMAN [view interactions] High throughput no yes
OBSCN_HUMAN [view interactions] High throughput no yes
ARL4D_HUMAN [view interactions] High throughput no no
GPR17_HUMAN [view interactions] High throughput no no
IOD3_HUMAN [view interactions] High throughput no no
PLCB_HUMAN [view interactions] High throughput no yes
GPR35_HUMAN [view interactions] High throughput no no
GTR1_HUMAN [view entry] [view interactions] High throughput yes no
AT1B3_HUMAN [view interactions] High throughput no yes
RGF1A_HUMAN [view interactions] High throughput no yes
LYZL2_HUMAN [view interactions] High throughput no no
NXT2_HUMAN [view interactions] High throughput no yes
LHPL4_HUMAN [view entry] [view interactions] High throughput yes no
CPT1A_HUMAN [view entry] [view interactions] High throughput yes yes
MPU1_HUMAN [view interactions] High throughput no yes
SGCA_HUMAN [view interactions] High throughput no yes
CD8B_HUMAN [view interactions] High throughput no no
TSN15_HUMAN [view interactions] High throughput no yes
HACL2_HUMAN [view interactions] High throughput no yes
RAMP3_HUMAN [view interactions] High throughput no no
TM11B_HUMAN [view interactions] High throughput no no
SNG1_HUMAN [view entry] [view interactions] High throughput yes yes
S22A9_HUMAN [view interactions] High throughput no no
AUP1_HUMAN [view interactions] High throughput no yes
TYOBP_HUMAN [view interactions] High throughput no no
PVRIG_HUMAN [view interactions] High throughput no yes
P2RX2_HUMAN [view entry] [view interactions] High throughput yes no
GPAT4_HUMAN [view interactions] High throughput no yes
ARL5B_HUMAN [view interactions] High throughput no yes
DRB3_HUMAN [view interactions] High throughput no no
NAA30_HUMAN [view interactions] High throughput no no
FFAR1_HUMAN [view interactions] High throughput no no
S1PR4_HUMAN [view interactions] High throughput no no
TMM72_HUMAN [view interactions] High throughput no no
DHC24_HUMAN [view interactions] High throughput no yes
LYZL6_HUMAN [view interactions] High throughput no no
KLK5_HUMAN [view interactions] High throughput no no
TRFM_HUMAN [view interactions] High throughput no yes
B3GN3_HUMAN [view interactions] High throughput no no
EDNRA_HUMAN [view interactions] High throughput no yes
TPST2_HUMAN [view interactions] High throughput no yes
SIAT9_HUMAN [view interactions] High throughput no no
SIA4A_HUMAN [view interactions] High throughput no yes
PKR1_HUMAN [view interactions] High throughput no no
KLRD1_HUMAN [view interactions] High throughput no no
GPBAR_HUMAN [view interactions] High throughput no no
TR10C_HUMAN [view interactions] High throughput no no
FPR2_HUMAN [view interactions] High throughput no yes
MFD4A_HUMAN [view interactions] High throughput no yes
ASPH_HUMAN [view interactions] High throughput no yes
LRAD1_HUMAN [view interactions] High throughput no no
GPR45_HUMAN [view interactions] High throughput no no
CD83_HUMAN [view interactions] High throughput no yes
LEUK_HUMAN [view interactions] High throughput no no
DECR2_HUMAN [view entry] [view interactions] High throughput yes no
CCG4_HUMAN [view entry] [view interactions] High throughput yes no
SIGL1_HUMAN [view interactions] High throughput no no
SFXN5_HUMAN [view entry] [view interactions] High throughput yes no
DMB_HUMAN [view interactions] High throughput no no
PTAFR_HUMAN [view interactions] High throughput no yes
SH23A_HUMAN [view interactions] High throughput no no
DKKL1_HUMAN [view interactions] High throughput no no
P2RY8_HUMAN [view interactions] High throughput no no
GPR55_HUMAN [view interactions] High throughput no no
SC22B_HUMAN [view entry] [view interactions] High throughput yes no
NCEH1_HUMAN [view interactions] High throughput no yes
PACC1_HUMAN [view interactions] High throughput no no
STK16_HUMAN [view interactions] High throughput no no
DTWD2_HUMAN [view interactions] High throughput no no
RER1_HUMAN [view interactions] High throughput no yes
FA2H_HUMAN [view interactions] High throughput no yes
LAGE3_HUMAN [view interactions] High throughput no yes
CXCR4_HUMAN [view interactions] High throughput no no
CLC4E_HUMAN [view interactions] High throughput no no
DPB1_HUMAN [view interactions] High throughput no no
LRC25_HUMAN [view interactions] High throughput no yes
EFNA2_HUMAN [view interactions] High throughput no no
EI24_HUMAN [view interactions] High throughput no yes
NK1R_HUMAN [view entry] [view interactions] High throughput yes no
S25A3_HUMAN [view entry] [view interactions] High throughput yes no
TRML1_HUMAN [view interactions] High throughput no no
TNR9_HUMAN [view interactions] High throughput no no
ENTP7_HUMAN [view interactions] High throughput no no
ALG2_HUMAN [view interactions] High throughput no yes
UPK2_HUMAN [view interactions] High throughput no no
GP182_HUMAN [view interactions] High throughput no no
LRN4L_HUMAN [view interactions] High throughput no yes
MRGX4_HUMAN [view interactions] High throughput no no
F174A_HUMAN [view interactions] High throughput no yes
BTNL9_HUMAN [view interactions] High throughput no no
SHSL1_HUMAN [view interactions] High throughput no yes
P2RX1_HUMAN [view entry] [view interactions] High throughput yes no
SNX21_HUMAN [view interactions] High throughput no yes
CST9L_HUMAN [view interactions] High throughput no no
TMEM9_HUMAN [view interactions] High throughput no no
AGK_HUMAN [view entry] [view interactions] High throughput yes yes
KCMB2_HUMAN [view interactions] High throughput no yes
AGRE5_HUMAN [view interactions] High throughput no no
GPR84_HUMAN [view interactions] High throughput no no
PRND_HUMAN [view interactions] High throughput no no
NAAA_HUMAN [view interactions] High throughput no yes
IRF3_HUMAN [view interactions] High throughput no yes
GPV_HUMAN [view interactions] High throughput no no
DHR13_HUMAN [view interactions] High throughput no yes
NTR1_HUMAN [view interactions] High throughput no no
GRAH_HUMAN [view interactions] High throughput no no
CTDS1_HUMAN [view interactions] High throughput no no
PAR2_HUMAN [view entry] [view interactions] High throughput yes yes
GP173_HUMAN [view interactions] High throughput no no
P2RY2_HUMAN [view interactions] High throughput no no
MAP1B_HUMAN [view entry] [view interactions] High throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
ASXL2_HUMAN [view interactions] High throughput no no
ASXL1_HUMAN [view interactions] High throughput no no
PRRT2_HUMAN [view entry] [view interactions] High throughput yes no
UBP48_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
SPRNG_HUMAN [view interactions] High throughput no yes
AGO2_HUMAN [view entry] [view interactions] High throughput yes yes
S1PR1_HUMAN [view interactions] High throughput no no
AT1B4_HUMAN [view interactions] High throughput no no
SPP2B_HUMAN [view interactions] High throughput no yes
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
LRRN2_HUMAN [view interactions] High throughput no yes
RAB1A_HUMAN [view entry] [view interactions] High throughput yes yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
RAB1B_HUMAN [view entry] [view interactions] High throughput yes yes
LRRK2_HUMAN [view interactions] High throughput no yes
VA0D1_HUMAN [view entry] [view interactions] High throughput yes yes
MTR1B_HUMAN [view interactions] High throughput no yes
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
PSN1_HUMAN [view entry] [view interactions] High throughput yes yes
TCPH_HUMAN [view entry] [view interactions] High throughput yes yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
VDAC1_HUMAN [view entry] [view interactions] High throughput yes yes
MK03_HUMAN [view entry] [view interactions] High throughput yes yes
VDAC2_HUMAN [view entry] [view interactions] High throughput yes yes
VAMP2_HUMAN [view entry] [view interactions] High throughput yes no
AGO3_HUMAN [view interactions] High throughput no yes
KCMA1_HUMAN [view entry] [view interactions] High throughput yes no
MYCBP_HUMAN [view interactions] High throughput no yes
STING_HUMAN [view interactions] High throughput no yes
KBTB4_HUMAN [view interactions] High throughput no yes
SSR3_HUMAN [view interactions] High throughput no yes
RD3_HUMAN [view interactions] High throughput no no
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
ITM2B_HUMAN [view interactions] High throughput no yes
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
RIMS1_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
SCN2A_HUMAN [view entry] [view interactions] High throughput yes yes
DYR1A_HUMAN [view interactions] High throughput no yes
CASP8_HUMAN [view interactions] High throughput no yes
BOK_HUMAN [view interactions] High throughput no no
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
EYA3_HUMAN [view interactions] High throughput no no
SKIL_HUMAN [view interactions] High throughput no yes
TP53B_HUMAN [view entry] [view interactions] High throughput yes yes
ZNF20_HUMAN [view interactions] High throughput no no
ESRP1_HUMAN [view interactions] High throughput no yes
VAC14_HUMAN [view entry] [view interactions] High throughput yes yes
SPIR1_HUMAN [view entry] [view interactions] High throughput yes yes
NPFF1_HUMAN [view interactions] High throughput no no
SYNCI_HUMAN [view interactions] High throughput no no
PNMA5_HUMAN [view interactions] High throughput no yes
ASCL4_HUMAN [view interactions] High throughput no no
ZBT49_HUMAN [view interactions] High throughput no yes
INCA1_HUMAN [view interactions] High throughput no no
RAB3A_HUMAN [view entry] [view interactions] High throughput yes yes
M4A6A_HUMAN [view interactions] High throughput no yes
PHS_HUMAN [view interactions] High throughput no yes
APH1A_HUMAN [view interactions] High throughput no yes
APH1B_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
NAC1_HUMAN [view entry] [view interactions] High throughput yes yes
ITPR1_HUMAN [view entry] [view interactions] High throughput yes yes
SPTN1_HUMAN [view entry] [view interactions] High throughput yes yes
CLN5_HUMAN [view interactions] High throughput no yes
LGR4_HUMAN [view interactions] High throughput no yes
GLYM_HUMAN [view entry] [view interactions] High throughput yes yes
F187B_HUMAN [view interactions] High throughput no no
RIC3_HUMAN [view interactions] High throughput no yes
TMIG3_HUMAN [view interactions] High throughput no no
AA3R_HUMAN [view interactions] High throughput no no
ANM6_HUMAN [view interactions] High throughput no yes
IL17_HUMAN [view interactions] High throughput no no
GHC1_HUMAN [view entry] [view interactions] High throughput yes yes
CGRF1_HUMAN [view interactions] High throughput no yes
HLAB_HUMAN [view interactions] High throughput no yes
HLAC_HUMAN [view interactions] High throughput no no
SLAF1_HUMAN [view interactions] High throughput no no
DLK1_HUMAN [view interactions] High throughput no no
TEFF1_HUMAN [view interactions] High throughput no no
VPS4A_HUMAN [view entry] [view interactions] High throughput yes yes
ERGI3_HUMAN [view interactions] High throughput no yes
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
AKA28_HUMAN [view interactions] High throughput no no
LYPD6_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
CRY2_HUMAN [view interactions] High throughput no yes
TGFB1_HUMAN [view interactions] High throughput no no
HEXI1_HUMAN [view interactions] High throughput no yes
UBE3A_HUMAN [view entry] [view interactions] High throughput yes yes
SNAI1_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
GRWD1_HUMAN [view interactions] High throughput no no
LMBRL_HUMAN [view interactions] High throughput no no
GBRL1_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
HCST_HUMAN [view interactions] High throughput no no
G3ST2_HUMAN [view interactions] High throughput no no
TOM22_HUMAN [view interactions] High throughput no yes
HIG1A_HUMAN [view entry] [view interactions] High throughput yes yes
NK3R_HUMAN [view interactions] High throughput no no
VCAM1_HUMAN [view interactions] High throughput no no
GLR_HUMAN [view interactions] High throughput no no
COX42_HUMAN [view interactions] High throughput no no
SRPRA_HUMAN [view interactions] High throughput no no
TMX2_HUMAN [view interactions] High throughput no yes
X3CL1_HUMAN [view interactions] High throughput no yes
ATP4A_HUMAN [view entry] [view interactions] High throughput yes no
KI2L4_HUMAN [view interactions] High throughput no no
GPR88_HUMAN [view interactions] High throughput no no
RXLT1_HUMAN [view interactions] High throughput no no
EDNRB_HUMAN [view interactions] High throughput no no
OPRX_HUMAN [view interactions] High throughput no no
C5AR1_HUMAN [view interactions] High throughput no yes
WBP1_HUMAN [view interactions] High throughput no yes
TM223_HUMAN [view interactions] High throughput no yes
I17RB_HUMAN [view interactions] High throughput no no
AT1B2_HUMAN [view entry] [view interactions] High throughput yes no
S15A1_HUMAN [view interactions] High throughput no no
PCD10_HUMAN [view entry] [view interactions] High throughput yes yes
HUMMR_HUMAN [view interactions] High throughput no yes