Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DECR2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DECR2_HUMAN
GO:0046872 metal ion binding 33.3333 4 no
GO:0032555 purine ribonucleotide binding 20.8333 4 no
GO:0032559 adenyl ribonucleotide binding 20.8333 5 no
GO:0003779 actin binding 20.8333 4 no
GO:0045296 cadherin binding 20.8333 4 no
GO:0017076 purine nucleotide binding 20.8333 4 no
GO:0030554 adenyl nucleotide binding 20.8333 5 no
GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity 8.3333 5 yes
GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 8.3333 4 yes
GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity 8.3333 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DECR2_HUMAN
GO:0048523 negative regulation of cellular process 45.8333 4 no
GO:0048522 positive regulation of cellular process 41.6667 4 no
GO:0060255 regulation of macromolecule metabolic process 41.6667 4 no
GO:0030030 cell projection organization 37.5000 4 no
GO:0031323 regulation of cellular metabolic process 33.3333 4 no
GO:0051171 regulation of nitrogen compound metabolic process 33.3333 4 no
GO:0080090 regulation of primary metabolic process 33.3333 4 no
GO:0009893 positive regulation of metabolic process 33.3333 4 no
GO:0010468 regulation of gene expression 33.3333 5 no
GO:0120036 plasma membrane bounded cell projection organization 33.3333 5 no
GO:0051128 regulation of cellular component organization 29.1667 4 no
GO:0010604 positive regulation of macromolecule metabolic process 29.1667 5 no
GO:0010646 regulation of cell communication 29.1667 4 no
GO:0006631 fatty acid metabolic process 25.0000 4 yes
GO:0019752 carboxylic acid metabolic process 25.0000 5 yes
GO:0032787 monocarboxylic acid metabolic process 25.0000 6 yes
GO:0043436 oxoacid metabolic process 25.0000 4 yes
GO:0051246 regulation of protein metabolic process 25.0000 5 no
GO:0051049 regulation of transport 25.0000 4 no
GO:0009966 regulation of signal transduction 25.0000 4 no
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0048584 positive regulation of response to stimulus 25.0000 4 no
GO:0010628 positive regulation of gene expression 25.0000 6 no
GO:0071310 cellular response to organic substance 25.0000 4 no
GO:0006635 fatty acid beta-oxidation 20.8333 6 yes
GO:0009062 fatty acid catabolic process 20.8333 5 yes
GO:0016042 lipid catabolic process 20.8333 4 yes
GO:0016054 organic acid catabolic process 20.8333 4 yes
GO:0019395 fatty acid oxidation 20.8333 5 yes
GO:0030258 lipid modification 20.8333 4 yes
GO:0034440 lipid oxidation 20.8333 5 yes
GO:0044242 cellular lipid catabolic process 20.8333 4 yes
GO:0046395 carboxylic acid catabolic process 20.8333 5 yes
GO:0072329 monocarboxylic acid catabolic process 20.8333 6 yes
GO:0036211 protein modification process 20.8333 4 no
GO:0043412 macromolecule modification 20.8333 4 no
GO:0006996 organelle organization 20.8333 4 no
GO:0045595 regulation of cell differentiation 20.8333 4 no
GO:0045596 negative regulation of cell differentiation 20.8333 5 no
GO:0051093 negative regulation of developmental process 20.8333 4 no
GO:0051241 negative regulation of multicellular organismal process 20.8333 4 no
GO:0009889 regulation of biosynthetic process 20.8333 4 no
GO:0010556 regulation of macromolecule biosynthetic process 20.8333 5 no
GO:0031325 positive regulation of cellular metabolic process 20.8333 5 no
GO:0031326 regulation of cellular biosynthetic process 20.8333 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 20.8333 5 no
GO:0006796 phosphate-containing compound metabolic process 20.8333 4 no
GO:0048878 chemical homeostasis 20.8333 4 no
GO:0051050 positive regulation of transport 20.8333 4 no
GO:1902531 regulation of intracellular signal transduction 20.8333 5 no
GO:1902533 positive regulation of intracellular signal transduction 20.8333 6 no
GO:0010243 response to organonitrogen compound 20.8333 4 no
GO:0014070 response to organic cyclic compound 20.8333 4 no
GO:0008202 steroid metabolic process 20.8333 4 no
GO:0008610 lipid biosynthetic process 16.6667 4 yes
GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase 16.6667 7 yes
GO:0016053 organic acid biosynthetic process 12.5000 4 yes
GO:0033559 unsaturated fatty acid metabolic process 12.5000 5 yes
GO:0046394 carboxylic acid biosynthetic process 12.5000 5 yes
GO:0072330 monocarboxylic acid biosynthetic process 12.5000 6 yes
GO:0006633 fatty acid biosynthetic process 8.3333 5 yes
GO:0006636 unsaturated fatty acid biosynthetic process 8.3333 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DECR2_HUMAN [view entry] [view interactions] Low throughput yes no
EP300_HUMAN [view interactions] High throughput no yes
FLNB_HUMAN [view interactions] High throughput no no
PP2AB_HUMAN [view interactions] High throughput no yes
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
RNH2A_HUMAN [view interactions] High throughput no no
GARE1_HUMAN [view interactions] High throughput no yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
PTN11_HUMAN [view entry] [view interactions] High throughput yes yes
PTPRC_HUMAN [view interactions] High throughput no no
SHF_HUMAN [view interactions] High throughput no no
CN119_HUMAN [view interactions] High throughput no yes
UBP11_HUMAN [view interactions] High throughput no yes
OSGI1_HUMAN [view interactions] High throughput no no
VP26C_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
TRI63_HUMAN [view interactions] High throughput no no
TRI55_HUMAN [view interactions] High throughput no no
CATA_HUMAN [view entry] [view interactions] High throughput yes no
PEX5_HUMAN [view interactions] High throughput no yes
SESD1_HUMAN [view entry] [view interactions] High throughput yes no
NHRF3_HUMAN [view interactions] High throughput no no
GLMP_HUMAN [view interactions] High throughput no no
ZUP1_HUMAN [view interactions] High throughput no yes
PIHD1_HUMAN [view interactions] High throughput no yes
SHRPN_HUMAN [view entry] [view interactions] High throughput yes yes
ESR2_HUMAN [view interactions] High throughput no no
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
CUL4A_HUMAN [view interactions] High throughput no no
WDTC1_HUMAN [view interactions] High throughput no yes
OSTM1_HUMAN [view interactions] High throughput no yes
ITA8_HUMAN [view entry] [view interactions] High throughput yes no
PGFRA_HUMAN [view interactions] High throughput no no
FFAR1_HUMAN [view interactions] High throughput no no
AT2B2_HUMAN [view entry] [view interactions] High throughput yes yes
TMPS5_HUMAN [view interactions] High throughput no no
MFD4A_HUMAN [view interactions] High throughput no yes
GP107_HUMAN [view interactions] High throughput no yes
ESRP2_HUMAN [view interactions] High throughput no yes
AT1A3_HUMAN [view entry] [view interactions] High throughput yes no
RAMP3_HUMAN [view interactions] High throughput no no
SEN15_HUMAN [view interactions] High throughput no yes
GPR45_HUMAN [view interactions] High throughput no no
BASI_HUMAN [view entry] [view interactions] High throughput yes no
GBP3_HUMAN [view interactions] High throughput no yes
DMB_HUMAN [view interactions] High throughput no no
TRI26_HUMAN [view interactions] High throughput no yes
RHOH_HUMAN [view interactions] High throughput no yes
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
GORS2_HUMAN [view interactions] High throughput no yes
NED4L_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
ADAS_HUMAN [view interactions] High throughput no yes
S27A2_HUMAN [view interactions] Computational no no
NUD19_HUMAN [view interactions] Computational no no
ACOX3_HUMAN [view interactions] Computational no yes
ECI2_HUMAN [view entry] [view interactions] Computational yes yes
TYSD1_HUMAN [view interactions] Computational no yes
ACOX2_HUMAN [view interactions] Computational no yes
SCP2_HUMAN [view interactions] Computational no no
DCMC_HUMAN [view interactions] Computational no no
ACOT8_HUMAN [view entry] [view interactions] Computational yes yes
GNPAT_HUMAN [view entry] [view interactions] Computational yes no
HAOX2_HUMAN [view interactions] Computational no no
BAAT_HUMAN [view interactions] Computational no no
ACOT2_HUMAN [view interactions] Computational no yes
OCTC_HUMAN [view interactions] Computational no yes
ACOT4_HUMAN [view interactions] Computational no yes
DHRS4_HUMAN [view entry] [view interactions] Computational yes no
NOS2_HUMAN [view interactions] Computational no yes
GSTK1_HUMAN [view entry] [view interactions] Computational yes yes
NUDT7_HUMAN [view interactions] Computational no yes
MPV17_HUMAN [view interactions] Computational no no
ACOX1_HUMAN [view interactions] Computational no yes
PECR_HUMAN [view interactions] Computational no yes
AMACR_HUMAN [view interactions] Computational no yes
CACP_HUMAN [view entry] [view interactions] Computational yes yes
OXDA_HUMAN [view interactions] Computational no no
ECH1_HUMAN [view interactions] Computational no yes
HAOX1_HUMAN [view interactions] Computational no no
SPYA_HUMAN [view interactions] Computational no no
IDE_HUMAN [view interactions] Computational no yes
IDHC_HUMAN [view interactions] Computational no no
HACL1_HUMAN [view interactions] Computational no no
HMGCL_HUMAN [view interactions] Computational no yes
PAOX_HUMAN [view interactions] Computational no no
LONP2_HUMAN [view interactions] Computational no yes
ECHP_HUMAN [view interactions] Computational no no
SOX_HUMAN [view interactions] Computational no no
HYES_HUMAN [view interactions] Computational no no
OXDD_HUMAN [view interactions] Computational no yes