Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DECR2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DECR2_HUMAN
GO:0043169 cation binding 45.0000 4 no
GO:0046872 metal ion binding 45.0000 5 no
GO:0000166 nucleotide binding 30.0000 4 no
GO:0017076 purine nucleotide binding 30.0000 5 no
GO:0030554 adenyl nucleotide binding 30.0000 6 no
GO:0043168 anion binding 30.0000 4 no
GO:0005524 ATP binding 25.0000 5 no
GO:0032555 purine ribonucleotide binding 25.0000 4 no
GO:0032559 adenyl ribonucleotide binding 25.0000 5 no
GO:0035639 purine ribonucleoside triphosphate binding 25.0000 4 no
GO:0003779 actin binding 25.0000 4 no
GO:0045296 cadherin binding 25.0000 4 no
GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity 10.0000 5 yes
GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 10.0000 4 yes
GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity 10.0000 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DECR2_HUMAN
GO:0048522 positive regulation of cellular process 60.0000 4 no
GO:0048523 negative regulation of cellular process 60.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0009893 positive regulation of metabolic process 45.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 45.0000 5 no
GO:0051128 regulation of cellular component organization 45.0000 4 no
GO:0031323 regulation of cellular metabolic process 45.0000 4 no
GO:0080090 regulation of primary metabolic process 40.0000 4 no
GO:0009889 regulation of biosynthetic process 40.0000 4 no
GO:0009891 positive regulation of biosynthetic process 40.0000 5 no
GO:0010468 regulation of gene expression 40.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 40.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 40.0000 6 no
GO:0010646 regulation of cell communication 40.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 40.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 40.0000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 40.0000 6 no
GO:0030030 cell projection organization 40.0000 4 no
GO:0036211 protein modification process 35.0000 4 no
GO:0043412 macromolecule modification 35.0000 4 no
GO:0051246 regulation of protein metabolic process 35.0000 5 no
GO:0009966 regulation of signal transduction 35.0000 4 no
GO:0009967 positive regulation of signal transduction 35.0000 5 no
GO:0010647 positive regulation of cell communication 35.0000 5 no
GO:0023056 positive regulation of signaling 35.0000 4 no
GO:0048584 positive regulation of response to stimulus 35.0000 4 no
GO:0120036 plasma membrane bounded cell projection organization 35.0000 5 no
GO:0051049 regulation of transport 30.0000 4 no
GO:0051247 positive regulation of protein metabolic process 30.0000 6 no
GO:0008104 protein localization 30.0000 4 no
GO:1902531 regulation of intracellular signal transduction 30.0000 5 no
GO:1902533 positive regulation of intracellular signal transduction 30.0000 6 no
GO:0010628 positive regulation of gene expression 30.0000 7 no
GO:0022603 regulation of anatomical structure morphogenesis 25.0000 4 no
GO:0001932 regulation of protein phosphorylation 25.0000 7 no
GO:0006996 organelle organization 25.0000 4 no
GO:0019220 regulation of phosphate metabolic process 25.0000 6 no
GO:0031399 regulation of protein modification process 25.0000 6 no
GO:0042325 regulation of phosphorylation 25.0000 7 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0045595 regulation of cell differentiation 25.0000 4 no
GO:0051174 regulation of phosphorus metabolic process 25.0000 5 no
GO:0010243 response to organonitrogen compound 25.0000 4 no
GO:0009062 fatty acid catabolic process 10.0000 5 yes
GO:0016042 lipid catabolic process 10.0000 4 yes
GO:0016053 organic acid biosynthetic process 10.0000 4 yes
GO:0016054 organic acid catabolic process 10.0000 4 yes
GO:0019395 fatty acid oxidation 10.0000 5 yes
GO:0019752 carboxylic acid metabolic process 10.0000 5 yes
GO:0030258 lipid modification 10.0000 4 yes
GO:0032787 monocarboxylic acid metabolic process 10.0000 6 yes
GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase 10.0000 7 yes
GO:0033559 unsaturated fatty acid metabolic process 10.0000 5 yes
GO:0034440 lipid oxidation 10.0000 5 yes
GO:0043436 oxoacid metabolic process 10.0000 4 yes
GO:0044242 cellular lipid catabolic process 10.0000 4 yes
GO:0046394 carboxylic acid biosynthetic process 10.0000 5 yes
GO:0046395 carboxylic acid catabolic process 10.0000 5 yes
GO:0072329 monocarboxylic acid catabolic process 10.0000 6 yes
GO:0072330 monocarboxylic acid biosynthetic process 10.0000 6 yes
GO:0006631 fatty acid metabolic process 10.0000 4 yes
GO:0006633 fatty acid biosynthetic process 10.0000 5 yes
GO:0006635 fatty acid beta-oxidation 10.0000 6 yes
GO:0006636 unsaturated fatty acid biosynthetic process 10.0000 6 yes
GO:0008610 lipid biosynthetic process 10.0000 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DECR2_HUMAN [view entry] [view interactions] Low throughput yes no
EP300_HUMAN [view interactions] High throughput no yes
FLNB_HUMAN [view interactions] High throughput no no
PP2AB_HUMAN [view interactions] High throughput no yes
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
RNH2A_HUMAN [view interactions] High throughput no no
GARE1_HUMAN [view interactions] High throughput no yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
PTN11_HUMAN [view entry] [view interactions] High throughput yes yes
PTPRC_HUMAN [view interactions] High throughput no no
SHF_HUMAN [view interactions] High throughput no no
CN119_HUMAN [view interactions] High throughput no yes
UBP11_HUMAN [view interactions] High throughput no yes
OSGI1_HUMAN [view interactions] High throughput no no
VP26C_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
TRI63_HUMAN [view interactions] High throughput no no
TRI55_HUMAN [view interactions] High throughput no no
CATA_HUMAN [view entry] [view interactions] High throughput yes no
PEX5_HUMAN [view interactions] High throughput no yes
SESD1_HUMAN [view entry] [view interactions] High throughput yes no
NHRF3_HUMAN [view interactions] High throughput no no
GLMP_HUMAN [view interactions] High throughput no no
ZUP1_HUMAN [view interactions] High throughput no yes
PIHD1_HUMAN [view interactions] High throughput no yes
SHRPN_HUMAN [view entry] [view interactions] High throughput yes yes
ESR2_HUMAN [view interactions] High throughput no no
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
CUL4A_HUMAN [view interactions] High throughput no no
WDTC1_HUMAN [view interactions] High throughput no yes
OSTM1_HUMAN [view interactions] High throughput no yes
ITA8_HUMAN [view entry] [view interactions] High throughput yes no
PGFRA_HUMAN [view interactions] High throughput no no
FFAR1_HUMAN [view interactions] High throughput no no
AT2B2_HUMAN [view entry] [view interactions] High throughput yes yes
TMPS5_HUMAN [view interactions] High throughput no no
MFD4A_HUMAN [view interactions] High throughput no yes
GP107_HUMAN [view interactions] High throughput no yes
ESRP2_HUMAN [view interactions] High throughput no yes
AT1A3_HUMAN [view entry] [view interactions] High throughput yes no
RAMP3_HUMAN [view interactions] High throughput no no
SEN15_HUMAN [view interactions] High throughput no yes
GPR45_HUMAN [view interactions] High throughput no no
BASI_HUMAN [view entry] [view interactions] High throughput yes no
GBP3_HUMAN [view interactions] High throughput no yes
DMB_HUMAN [view interactions] High throughput no no
TRI26_HUMAN [view interactions] High throughput no yes
RHOH_HUMAN [view interactions] High throughput no yes
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
GORS2_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
HSF1_HUMAN [view interactions] High throughput no yes
NED4L_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
ADAS_HUMAN [view interactions] High throughput no yes