Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AT2B2_HUMAN

ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems (PubMed, PubMed). Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment (PubMed, PubMed). Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics. At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning . Plays an essential role in hearing and balance (PubMed, PubMed). In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia (PubMed, PubMed). In non-excitable cells, regulates Ca(2+) signaling through spatial control of Ca(2+) ions extrusion and dissipation of Ca(2+) transients generated by store-operated channels (PubMed). In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk . [View more on UniProt]

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ELM instance Name Type Start End Partner
ELMI002439 LIG_PDZ_Class_1 LIG 1238 1243 -
ELMI004290 TRG_DiLeu_BaLyEn_6 TRG 1180 1185 -

Molecular function

Term Name % Distance from the top of the tree Annotated in AT2B2_HUMAN
GO:0046872 metal ion binding 29.1667 4 yes
GO:0017076 purine nucleotide binding 25.0000 4 yes
GO:0032555 purine ribonucleotide binding 25.0000 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 25.0000 4 yes
GO:0019900 kinase binding 22.9167 4 no
GO:0005524 ATP binding 20.8333 5 yes
GO:0008324 cation transmembrane transporter activity 20.8333 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 20.8333 4 yes
GO:0030554 adenyl nucleotide binding 20.8333 5 yes
GO:0032559 adenyl ribonucleotide binding 20.8333 5 yes
GO:0005509 calcium ion binding 18.7500 5 yes
GO:0046873 metal ion transmembrane transporter activity 14.5833 5 yes
GO:0015085 calcium ion transmembrane transporter activity 12.5000 6 yes
GO:0015399 primary active transmembrane transporter activity 12.5000 4 yes
GO:0030165 PDZ domain binding 12.5000 4 yes
GO:0035254 glutamate receptor binding 12.5000 4 yes
GO:0022853 active ion transmembrane transporter activity 10.4167 4 yes
GO:0005388 P-type calcium transporter activity 6.2500 4 yes
GO:0015662 P-type ion transporter activity 6.2500 4 yes
GO:1905056 P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration 4.1667 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in AT2B2_HUMAN
GO:0048522 positive regulation of cellular process 58.3333 4 no
GO:0031323 regulation of cellular metabolic process 54.1667 4 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0051049 regulation of transport 45.8333 4 no
GO:0051171 regulation of nitrogen compound metabolic process 45.8333 4 no
GO:0009893 positive regulation of metabolic process 43.7500 4 no
GO:0010646 regulation of cell communication 43.7500 4 no
GO:0048523 negative regulation of cellular process 43.7500 4 no
GO:0031325 positive regulation of cellular metabolic process 39.5833 5 no
GO:0051246 regulation of protein metabolic process 39.5833 5 no
GO:0008104 protein localization 39.5833 4 no
GO:0009966 regulation of signal transduction 37.5000 4 no
GO:0009892 negative regulation of metabolic process 35.4167 4 no
GO:0010605 negative regulation of macromolecule metabolic process 35.4167 5 no
GO:0051128 regulation of cellular component organization 35.4167 4 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0010468 regulation of gene expression 31.2500 5 no
GO:0022607 cellular component assembly 31.2500 4 no
GO:0043085 positive regulation of catalytic activity 31.2500 4 no
GO:0043269 regulation of ion transport 31.2500 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 31.2500 5 no
GO:0019220 regulation of phosphate metabolic process 31.2500 6 no
GO:0031399 regulation of protein modification process 31.2500 6 no
GO:0051174 regulation of phosphorus metabolic process 31.2500 5 no
GO:0051247 positive regulation of protein metabolic process 29.1667 6 no
GO:0060341 regulation of cellular localization 29.1667 4 no
GO:0042325 regulation of phosphorylation 29.1667 7 no
GO:0030030 cell projection organization 29.1667 4 no
GO:0120036 plasma membrane bounded cell projection organization 29.1667 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 29.1667 5 no
GO:0044057 regulation of system process 29.1667 4 yes
GO:0051050 positive regulation of transport 27.0833 4 no
GO:0001932 regulation of protein phosphorylation 27.0833 7 no
GO:0010562 positive regulation of phosphorus metabolic process 27.0833 6 no
GO:0042327 positive regulation of phosphorylation 27.0833 8 no
GO:0045937 positive regulation of phosphate metabolic process 27.0833 7 no
GO:0032880 regulation of protein localization 27.0833 5 no
GO:0071702 organic substance transport 27.0833 4 no
GO:0031324 negative regulation of cellular metabolic process 27.0833 5 no
GO:0009889 regulation of biosynthetic process 25.0000 4 no
GO:0034762 regulation of transmembrane transport 25.0000 4 no
GO:0034765 regulation of ion transmembrane transport 25.0000 5 no
GO:1904062 regulation of cation transmembrane transport 25.0000 6 no
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0033674 positive regulation of kinase activity 25.0000 6 no
GO:0043549 regulation of kinase activity 25.0000 5 no
GO:0051338 regulation of transferase activity 25.0000 4 no
GO:0051347 positive regulation of transferase activity 25.0000 5 no
GO:0072657 protein localization to membrane 25.0000 4 no
GO:1902531 regulation of intracellular signal transduction 25.0000 5 no
GO:0010243 response to organonitrogen compound 22.9167 4 no
GO:0023056 positive regulation of signaling 22.9167 4 no
GO:0031326 regulation of cellular biosynthetic process 22.9167 5 no
GO:0050804 modulation of chemical synaptic transmission 22.9167 5 no
GO:0099177 regulation of trans-synaptic signaling 22.9167 4 no
GO:0045859 regulation of protein kinase activity 22.9167 6 no
GO:0045860 positive regulation of protein kinase activity 22.9167 7 no
GO:0031175 neuron projection development 22.9167 6 no
GO:0051248 negative regulation of protein metabolic process 22.9167 6 no
GO:0006996 organelle organization 22.9167 4 no
GO:0006811 ion transport 22.9167 4 yes
GO:0048878 chemical homeostasis 22.9167 4 yes
GO:0055080 cation homeostasis 20.8333 6 yes
GO:0098771 inorganic ion homeostasis 20.8333 6 yes
GO:1903522 regulation of blood circulation 20.8333 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 20.8333 5 no
GO:0010647 positive regulation of cell communication 20.8333 5 no
GO:0048584 positive regulation of response to stimulus 20.8333 4 no
GO:0042127 regulation of cell population proliferation 20.8333 4 no
GO:1903829 positive regulation of protein localization 20.8333 5 no
GO:0006812 cation transport 20.8333 5 yes
GO:0050801 ion homeostasis 20.8333 5 yes
GO:0006873 cellular ion homeostasis 18.7500 4 yes
GO:0008016 regulation of heart contraction 18.7500 6 yes
GO:0030003 cellular cation homeostasis 18.7500 5 yes
GO:0055065 metal ion homeostasis 18.7500 7 yes
GO:0006875 cellular metal ion homeostasis 16.6667 6 yes
GO:0072507 divalent inorganic cation homeostasis 14.5833 7 yes
GO:0030001 metal ion transport 14.5833 6 yes
GO:0055074 calcium ion homeostasis 14.5833 8 yes
GO:0072503 cellular divalent inorganic cation homeostasis 12.5000 6 yes
GO:0006874 cellular calcium ion homeostasis 12.5000 7 yes
GO:0006816 calcium ion transport 10.4167 7 yes
GO:0007420 brain development 8.3333 4 yes
GO:0051480 regulation of cytosolic calcium ion concentration 8.3333 8 yes
GO:1903779 regulation of cardiac conduction 6.2500 4 yes
GO:0030182 neuron differentiation 6.2500 4 yes
GO:0007600 sensory perception 4.1667 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in AT2B2_HUMAN
DOID:0050700 cardiomyopathy 6.2500 4 no
DOID:0060036 intrinsic cardiomyopathy 6.2500 5 no
DOID:114 heart disease 6.2500 3 no
DOID:2843 long QT syndrome 6.2500 6 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NMDZ1_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE1_HUMAN [view entry] [view interactions] Low throughput yes yes
STX1A_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
NHRF2_HUMAN [view entry] [view interactions] Low throughput yes no
1433E_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALC_HUMAN [view interactions] Low throughput no no
DLG3_HUMAN [view entry] [view interactions] Low throughput yes yes
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
CL12B_HUMAN [view interactions] High throughput no no
FZD2_HUMAN [view interactions] High throughput no no
IL2RA_HUMAN [view interactions] High throughput no no
CKLF5_HUMAN [view interactions] High throughput no yes
KI2L4_HUMAN [view interactions] High throughput no no
CQ078_HUMAN [view interactions] High throughput no no
CXCR4_HUMAN [view interactions] High throughput no no
CC018_HUMAN [view interactions] High throughput no yes
TM134_HUMAN [view interactions] High throughput no yes
TM39A_HUMAN [view interactions] High throughput no yes
EI2BB_HUMAN [view entry] [view interactions] High throughput yes yes
OX2R_HUMAN [view interactions] High throughput no no
CLM7_HUMAN [view interactions] High throughput no no
ADAM7_HUMAN [view interactions] High throughput no no
NK3R_HUMAN [view interactions] High throughput no no
OPALI_HUMAN [view interactions] High throughput no yes
NIPA3_HUMAN [view interactions] High throughput no no
ABCD3_HUMAN [view entry] [view interactions] High throughput yes yes
B3GN7_HUMAN [view interactions] High throughput no no
KLRD1_HUMAN [view interactions] High throughput no no
SNG1_HUMAN [view entry] [view interactions] High throughput yes yes
DECR2_HUMAN [view entry] [view interactions] High throughput yes no
P2RY8_HUMAN [view interactions] High throughput no no
ASIC4_HUMAN [view interactions] High throughput no no
K2C73_HUMAN [view interactions] High throughput no no
BASI_HUMAN [view entry] [view interactions] High throughput yes no
LYPD5_HUMAN [view interactions] High throughput no yes
AA2BR_HUMAN [view interactions] High throughput no no
GP173_HUMAN [view interactions] High throughput no no
S1PR4_HUMAN [view interactions] High throughput no no
CLCN3_HUMAN [view entry] [view interactions] High throughput yes yes
GPR45_HUMAN [view interactions] High throughput no no
ERBIN_HUMAN [view entry] [view interactions] High throughput yes yes
SNTA1_HUMAN [view entry] [view interactions] High throughput yes no
MYH15_HUMAN [view interactions] High throughput no yes
SCO1_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
LRRK2_HUMAN [view interactions] High throughput no yes
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
CD81_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
PIBF1_HUMAN [view interactions] High throughput no yes
PTPRQ_HUMAN [view interactions] High throughput no no
SCRIB_HUMAN [view entry] [view interactions] High throughput yes no
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
LGR4_HUMAN [view interactions] High throughput no yes
DQA1_HUMAN [view interactions] High throughput no yes
DRA_HUMAN [view interactions] High throughput no no
EFNB2_HUMAN [view entry] [view interactions] High throughput yes yes
DPH6_HUMAN [view interactions] High throughput no yes
SRPRB_HUMAN [view entry] [view interactions] High throughput yes no
NUFP1_HUMAN [view interactions] High throughput no yes
DGUOK_HUMAN [view interactions] High throughput no yes
KTU_HUMAN [view interactions] High throughput no yes
SACA1_HUMAN [view interactions] High throughput no no
LEG8_HUMAN [view entry] [view interactions] High throughput yes yes
TA2R7_HUMAN [view interactions] High throughput no no
GGH_HUMAN [view interactions] High throughput no yes
H17B6_HUMAN [view interactions] High throughput no yes
TRABD_HUMAN [view interactions] High throughput no yes
GINM1_HUMAN [view interactions] High throughput no yes
PF2R_HUMAN [view interactions] High throughput no no
CAB45_HUMAN [view interactions] High throughput no yes
SLAF1_HUMAN [view interactions] High throughput no no
DHRS9_HUMAN [view interactions] High throughput no yes
VSIG4_HUMAN [view interactions] High throughput no no
SCAR3_HUMAN [view interactions] High throughput no yes
UBXN8_HUMAN [view interactions] High throughput no yes
AOFB_HUMAN [view entry] [view interactions] High throughput yes yes
AT2B3_HUMAN [view entry] [view interactions] High throughput yes yes
GPAT1_HUMAN [view interactions] High throughput no no
NRM_HUMAN [view interactions] High throughput no no
F174A_HUMAN [view interactions] High throughput no yes
ABCD1_HUMAN [view entry] [view interactions] High throughput yes no
TM168_HUMAN [view interactions] High throughput no yes
AT2B4_HUMAN [view entry] [view interactions] High throughput yes yes
DGAT1_HUMAN [view interactions] High throughput no yes
APOD_HUMAN [view entry] [view interactions] High throughput yes yes
GOLM1_HUMAN [view interactions] High throughput no yes
LEMD2_HUMAN [view interactions] High throughput no yes
CLUS_HUMAN [view entry] [view interactions] High throughput yes yes
DHRS7_HUMAN [view interactions] High throughput no yes
B3A2_HUMAN [view interactions] High throughput no yes
PIGN_HUMAN [view interactions] High throughput no yes
MPC2_HUMAN [view interactions] High throughput no yes
STEA3_HUMAN [view interactions] High throughput no yes
OSTC_HUMAN [view interactions] High throughput no no
CERS6_HUMAN [view interactions] High throughput no yes
GOLI4_HUMAN [view interactions] High throughput no yes
AR6P1_HUMAN [view interactions] High throughput no yes
FZD7_HUMAN [view interactions] High throughput no yes
ERMP1_HUMAN [view interactions] High throughput no no
CP2B6_HUMAN [view interactions] High throughput no no
TOR1A_HUMAN [view interactions] High throughput no yes
S38A9_HUMAN [view interactions] High throughput no yes
CHSS1_HUMAN [view interactions] High throughput no no
PIGO_HUMAN [view interactions] High throughput no no
CO4A_HUMAN [view interactions] High throughput no no
FACR2_HUMAN [view interactions] High throughput no yes
CSCL1_HUMAN [view interactions] High throughput no no
MRP7_HUMAN [view interactions] High throughput no yes
RXLT1_HUMAN [view interactions] High throughput no no
ENTP7_HUMAN [view interactions] High throughput no no
CD83_HUMAN [view interactions] High throughput no yes
MRP4_HUMAN [view interactions] High throughput no no
GHDC_HUMAN [view interactions] High throughput no yes
GALT6_HUMAN [view interactions] High throughput no yes
LIRB4_HUMAN [view interactions] High throughput no no
CSCL2_HUMAN [view interactions] High throughput no yes
5HT2C_HUMAN [view interactions] High throughput no no
CD79B_HUMAN [view interactions] High throughput no no
MUCL1_HUMAN [view interactions] High throughput no no
FPR2_HUMAN [view interactions] High throughput no yes
FZD10_HUMAN [view interactions] High throughput no no
ERG1_HUMAN [view interactions] High throughput no no
ATG9A_HUMAN [view interactions] High throughput no yes
IL1R2_HUMAN [view interactions] High throughput no no
BAP31_HUMAN [view interactions] High throughput no yes
ZA2G_HUMAN [view interactions] High throughput no no
AG10A_HUMAN [view interactions] High throughput no yes
ABCD4_HUMAN [view interactions] High throughput no yes
PCX3_HUMAN [view interactions] High throughput no no
GTR5_HUMAN [view interactions] High throughput no yes
ALG8_HUMAN [view interactions] High throughput no yes
SIA4A_HUMAN [view interactions] High throughput no yes
TNPO3_HUMAN [view interactions] High throughput no yes
S22AG_HUMAN [view interactions] High throughput no yes
S47A1_HUMAN [view interactions] High throughput no no
ATS4_HUMAN [view interactions] High throughput no yes
PCDGD_HUMAN [view interactions] High throughput no no
IFNL1_HUMAN [view interactions] High throughput no no
PI2R_HUMAN [view interactions] High throughput no no
LPAR4_HUMAN [view interactions] High throughput no no
GLBL2_HUMAN [view interactions] High throughput no no
ABCB9_HUMAN [view interactions] High throughput no yes
S26A6_HUMAN [view interactions] High throughput no yes
S15A4_HUMAN [view interactions] High throughput no yes
5HT3A_HUMAN [view entry] [view interactions] High throughput yes no
BTBD9_HUMAN [view interactions] High throughput no yes
GOGA5_HUMAN [view interactions] High throughput no yes
GP161_HUMAN [view interactions] High throughput no yes
TIM23_HUMAN [view interactions] High throughput no yes
ATP9A_HUMAN [view interactions] High throughput no yes
VAC14_HUMAN [view entry] [view interactions] High throughput yes yes
S45A2_HUMAN [view interactions] High throughput no no
EDNRB_HUMAN [view interactions] High throughput no no
SPRNG_HUMAN [view interactions] High throughput no yes
MIRO2_HUMAN [view entry] [view interactions] High throughput yes yes
GPHRA_HUMAN [view interactions] High throughput no no
LCLT1_HUMAN [view interactions] High throughput no no
VAV_HUMAN [view interactions] High throughput no no
UXS1_HUMAN [view interactions] High throughput no yes
S4A7_HUMAN [view interactions] High throughput no no
RPGF5_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
INLR1_HUMAN [view interactions] High throughput no no
BTNL9_HUMAN [view interactions] High throughput no no
CPT1A_HUMAN [view entry] [view interactions] High throughput yes yes
DHB1_HUMAN [view interactions] High throughput no no
PTH2R_HUMAN [view interactions] High throughput no no
PCDG7_HUMAN [view interactions] High throughput no no
TS1R2_HUMAN [view interactions] High throughput no no
LAGE3_HUMAN [view interactions] High throughput no yes
LRC25_HUMAN [view interactions] High throughput no yes
GP182_HUMAN [view interactions] High throughput no no
ESYT2_HUMAN [view entry] [view interactions] High throughput yes yes
IDD_HUMAN [view interactions] High throughput no no
PCAT2_HUMAN [view interactions] High throughput no yes
TPST2_HUMAN [view interactions] High throughput no yes
CML1_HUMAN [view interactions] High throughput no yes
S1PR1_HUMAN [view interactions] High throughput no no
RXFP1_HUMAN [view interactions] High throughput no yes
CCR6_HUMAN [view interactions] High throughput no no
TTYH1_HUMAN [view entry] [view interactions] High throughput yes no
HIDE1_HUMAN [view interactions] High throughput no no
G3ST2_HUMAN [view interactions] High throughput no no
OPRX_HUMAN [view interactions] High throughput no no
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
C5AR1_HUMAN [view interactions] High throughput no yes
V2R_HUMAN [view interactions] High throughput no no
NPTN_HUMAN [view entry] [view interactions] High throughput yes yes
GPR88_HUMAN [view interactions] High throughput no no
TSN14_HUMAN [view interactions] High throughput no no
SLAF9_HUMAN [view interactions] High throughput no yes
KGP2_HUMAN [view entry] [view interactions] Computational yes yes
KGP1_HUMAN [view interactions] Computational no yes
ERBB2_HUMAN [view entry] [view interactions] Computational yes no