VAC14_HUMAN
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Position | Amino acid | Mutation | Disease | Overlap with binding region |
---|---|---|---|---|
424 | Trp | Leu | Striatonigraldegeneration,childhood-onset(SNDC) | - |
582 | Ala | Ser | Striatonigraldegeneration,childhood-onset(SNDC) | - |
583 | Ser | Leu | Striatonigraldegeneration,childhood-onset(SNDC) | - |
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in VAC14_HUMAN |
---|---|---|---|---|
GO:0043169 | cation binding | 30.0000 | 4 | no |
GO:0046872 | metal ion binding | 30.0000 | 5 | no |
GO:0019900 | kinase binding | 24.0000 | 4 | no |
GO:0043168 | anion binding | 22.0000 | 4 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in VAC14_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 66.0000 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 62.0000 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 58.0000 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 56.0000 | 4 | no |
GO:0048523 | negative regulation of cellular process | 54.0000 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 52.0000 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 48.0000 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 46.0000 | 5 | no |
GO:0051049 | regulation of transport | 44.0000 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 44.0000 | 4 | yes |
GO:0009966 | regulation of signal transduction | 44.0000 | 4 | no |
GO:0010646 | regulation of cell communication | 44.0000 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 44.0000 | 5 | no |
GO:0009889 | regulation of biosynthetic process | 42.0000 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 42.0000 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 42.0000 | 5 | no |
GO:0010468 | regulation of gene expression | 40.0000 | 6 | no |
GO:0008104 | protein localization | 36.0000 | 4 | no |
GO:0006996 | organelle organization | 36.0000 | 4 | no |
GO:0031399 | regulation of protein modification process | 34.0000 | 6 | no |
GO:0051247 | positive regulation of protein metabolic process | 34.0000 | 6 | no |
GO:0009892 | negative regulation of metabolic process | 34.0000 | 4 | no |
GO:0019220 | regulation of phosphate metabolic process | 32.0000 | 6 | no |
GO:0042325 | regulation of phosphorylation | 32.0000 | 7 | no |
GO:0051174 | regulation of phosphorus metabolic process | 32.0000 | 5 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 32.0000 | 5 | no |
GO:0001932 | regulation of protein phosphorylation | 30.0000 | 7 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.0000 | 5 | no |
GO:0060341 | regulation of cellular localization | 30.0000 | 4 | no |
GO:0031324 | negative regulation of cellular metabolic process | 30.0000 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 30.0000 | 5 | no |
GO:0023056 | positive regulation of signaling | 28.0000 | 4 | no |
GO:0031401 | positive regulation of protein modification process | 28.0000 | 7 | no |
GO:0048584 | positive regulation of response to stimulus | 28.0000 | 4 | no |
GO:0051252 | regulation of RNA metabolic process | 28.0000 | 5 | no |
GO:0051726 | regulation of cell cycle | 28.0000 | 4 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 26.0000 | 6 | no |
GO:0042327 | positive regulation of phosphorylation | 26.0000 | 8 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 26.0000 | 7 | no |
GO:0022607 | cellular component assembly | 26.0000 | 4 | no |
GO:0048585 | negative regulation of response to stimulus | 26.0000 | 4 | no |
GO:0001934 | positive regulation of protein phosphorylation | 24.0000 | 8 | no |
GO:0006355 | regulation of DNA-templated transcription | 24.0000 | 7 | no |
GO:0009891 | positive regulation of biosynthetic process | 24.0000 | 5 | no |
GO:0009967 | positive regulation of signal transduction | 24.0000 | 5 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 24.0000 | 6 | no |
GO:0010647 | positive regulation of cell communication | 24.0000 | 5 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 24.0000 | 6 | no |
GO:0051050 | positive regulation of transport | 24.0000 | 4 | no |
GO:2001141 | regulation of RNA biosynthetic process | 24.0000 | 6 | no |
GO:0032880 | regulation of protein localization | 24.0000 | 5 | no |
GO:0051130 | positive regulation of cellular component organization | 24.0000 | 5 | no |
GO:0033043 | regulation of organelle organization | 24.0000 | 5 | no |
GO:0051338 | regulation of transferase activity | 24.0000 | 4 | no |
GO:0009894 | regulation of catabolic process | 22.0000 | 4 | no |
GO:0030030 | cell projection organization | 22.0000 | 4 | no |
GO:0071310 | cellular response to organic substance | 22.0000 | 4 | no |
GO:0009968 | negative regulation of signal transduction | 22.0000 | 5 | no |
GO:0010648 | negative regulation of cell communication | 22.0000 | 5 | no |
GO:0023057 | negative regulation of signaling | 22.0000 | 4 | no |
GO:0043549 | regulation of kinase activity | 22.0000 | 5 | no |
GO:0060627 | regulation of vesicle-mediated transport | 18.0000 | 4 | yes |
GO:0030100 | regulation of endocytosis | 12.0000 | 5 | yes |
GO:0006796 | phosphate-containing compound metabolic process | 10.0000 | 4 | yes |
GO:0048259 | regulation of receptor-mediated endocytosis | 10.0000 | 6 | yes |
GO:0002090 | regulation of receptor internalization | 8.0000 | 7 | yes |
GO:0006644 | phospholipid metabolic process | 4.0000 | 4 | yes |
GO:0006650 | glycerophospholipid metabolic process | 4.0000 | 5 | yes |
GO:0006661 | phosphatidylinositol biosynthetic process | 4.0000 | 6 | yes |
GO:0008610 | lipid biosynthetic process | 4.0000 | 4 | yes |
GO:0008654 | phospholipid biosynthetic process | 4.0000 | 5 | yes |
GO:0045017 | glycerolipid biosynthetic process | 4.0000 | 4 | yes |
GO:0046474 | glycerophospholipid biosynthetic process | 4.0000 | 5 | yes |
GO:0046486 | glycerolipid metabolic process | 4.0000 | 4 | yes |
GO:0046488 | phosphatidylinositol metabolic process | 4.0000 | 6 | yes |
GO:0090407 | organophosphate biosynthetic process | 4.0000 | 4 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
FIG4_HUMAN | [view interactions] | Low throughput | no | yes |
FYV1_HUMAN | [view interactions] | Low throughput | no | no |
NBEL2_HUMAN | [view interactions] | Low throughput | no | no |
NOS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
LAMP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
EEA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TAU_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MTAP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
VAC14_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
VIP2_HUMAN | [view interactions] | High throughput | no | yes |
VIP1_HUMAN | [view interactions] | High throughput | no | yes |
PUR4_HUMAN | [view interactions] | High throughput | no | yes |
TCPG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
TFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IFM1_HUMAN | [view interactions] | High throughput | no | no |
IFM3_HUMAN | [view interactions] | High throughput | no | yes |
RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATG9A_HUMAN | [view interactions] | High throughput | no | yes |
TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RFA1_HUMAN | [view interactions] | High throughput | no | yes |
RFA3_HUMAN | [view interactions] | High throughput | no | yes |
PRAF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FACE1_HUMAN | [view interactions] | High throughput | no | yes |
MAOX_HUMAN | [view interactions] | High throughput | no | yes |
CLCN7_HUMAN | [view interactions] | High throughput | no | yes |
PYRD_HUMAN | [view interactions] | High throughput | no | yes |
VAMP3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MAVS_HUMAN | [view interactions] | High throughput | no | yes |
ERGI2_HUMAN | [view interactions] | High throughput | no | yes |
RAB21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AGTR1_HUMAN | [view interactions] | High throughput | no | no |
XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STA5B_HUMAN | [view interactions] | High throughput | no | yes |
SCRIB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IF4A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HSC20_HUMAN | [view interactions] | High throughput | no | yes |
SC16A_HUMAN | [view interactions] | High throughput | no | yes |
DOCK7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
STING_HUMAN | [view interactions] | High throughput | no | yes |
DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
CK5P2_HUMAN | [view interactions] | High throughput | no | yes |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
CRK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CDRT4_HUMAN | [view interactions] | High throughput | no | yes |
BHE40_HUMAN | [view interactions] | High throughput | no | yes |
SIGL5_HUMAN | [view interactions] | High throughput | no | no |
PHF1_HUMAN | [view interactions] | High throughput | no | yes |
RFOX2_HUMAN | [view interactions] | High throughput | no | yes |
JMJD7_HUMAN | [view interactions] | High throughput | no | yes |
CO8A1_HUMAN | [view interactions] | High throughput | no | no |
CASP1_HUMAN | [view interactions] | High throughput | no | yes |
PR20C_HUMAN | [view interactions] | High throughput | no | no |
TP53B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MPPD2_HUMAN | [view interactions] | High throughput | no | no |
LPAL2_HUMAN | [view interactions] | High throughput | no | no |
KAT1_HUMAN | [view interactions] | High throughput | no | yes |
KR195_HUMAN | [view interactions] | High throughput | no | no |
KR197_HUMAN | [view interactions] | High throughput | no | no |
SMUG1_HUMAN | [view interactions] | High throughput | no | no |
SPRY7_HUMAN | [view interactions] | High throughput | no | yes |
AT2L2_HUMAN | [view interactions] | High throughput | no | yes |
CC103_HUMAN | [view interactions] | High throughput | no | no |
ZNF34_HUMAN | [view interactions] | High throughput | no | no |
CF218_HUMAN | [view interactions] | High throughput | no | no |
CD033_HUMAN | [view interactions] | High throughput | no | no |
TEANC_HUMAN | [view interactions] | High throughput | no | no |
ASB13_HUMAN | [view interactions] | High throughput | no | yes |
PELI1_HUMAN | [view interactions] | High throughput | no | yes |
SNF8_HUMAN | [view interactions] | High throughput | no | yes |
NTAQ1_HUMAN | [view interactions] | High throughput | no | yes |
MTMR9_HUMAN | [view interactions] | High throughput | no | no |
RHXF2_HUMAN | [view interactions] | High throughput | no | no |
PADC1_HUMAN | [view interactions] | High throughput | no | yes |
CK054_HUMAN | [view interactions] | High throughput | no | no |
CD209_HUMAN | [view interactions] | High throughput | no | no |
NGB_HUMAN | [view interactions] | High throughput | no | yes |
ACS2L_HUMAN | [view interactions] | High throughput | no | yes |
PRR13_HUMAN | [view interactions] | High throughput | no | yes |
PSF3_HUMAN | [view interactions] | High throughput | no | yes |
KRA62_HUMAN | [view interactions] | High throughput | no | no |
WDR83_HUMAN | [view interactions] | High throughput | no | yes |
IF6_HUMAN | [view interactions] | High throughput | no | yes |
PR20D_HUMAN | [view interactions] | High throughput | no | no |
FA50B_HUMAN | [view interactions] | High throughput | no | yes |
HNF1B_HUMAN | [view interactions] | High throughput | no | no |
RNH2C_HUMAN | [view interactions] | High throughput | no | yes |
ARI5A_HUMAN | [view interactions] | High throughput | no | yes |
KRT82_HUMAN | [view interactions] | High throughput | no | no |
GABP2_HUMAN | [view interactions] | High throughput | no | yes |
KR193_HUMAN | [view interactions] | High throughput | no | no |
PPP6_HUMAN | [view interactions] | High throughput | no | yes |
OTOSP_HUMAN | [view interactions] | High throughput | no | no |
GLIS2_HUMAN | [view interactions] | High throughput | no | no |
UFSP1_HUMAN | [view interactions] | High throughput | no | yes |
ACPM_HUMAN | [view interactions] | High throughput | no | yes |
IF2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OIT3_HUMAN | [view interactions] | High throughput | no | no |
CTSRT_HUMAN | [view interactions] | High throughput | no | no |
ZBT49_HUMAN | [view interactions] | High throughput | no | yes |
CRBA2_HUMAN | [view interactions] | High throughput | no | no |
GBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HDHD3_HUMAN | [view interactions] | High throughput | no | yes |
PP2AA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KS6R_HUMAN | [view interactions] | High throughput | no | no |
KRA61_HUMAN | [view interactions] | High throughput | no | no |
KR151_HUMAN | [view interactions] | High throughput | no | no |
ECHP_HUMAN | [view interactions] | High throughput | no | no |
RHBL1_HUMAN | [view interactions] | High throughput | no | no |
EFMT3_HUMAN | [view interactions] | High throughput | no | no |
KRBX5_HUMAN | [view interactions] | High throughput | no | no |
PBLD_HUMAN | [view interactions] | High throughput | no | no |
TCAB1_HUMAN | [view interactions] | High throughput | no | yes |
VENTX_HUMAN | [view interactions] | High throughput | no | no |
VHLL_HUMAN | [view interactions] | High throughput | no | no |
INT11_HUMAN | [view interactions] | High throughput | no | yes |
MYOZ1_HUMAN | [view interactions] | High throughput | no | no |
RIPP1_HUMAN | [view interactions] | High throughput | no | no |
SMIP9_HUMAN | [view interactions] | High throughput | no | no |
CRBA1_HUMAN | [view interactions] | High throughput | no | no |
MYOME_HUMAN | [view interactions] | High throughput | no | no |
DDAH2_HUMAN | [view interactions] | High throughput | no | yes |
MGT5B_HUMAN | [view interactions] | High throughput | no | no |
FND3B_HUMAN | [view interactions] | High throughput | no | no |
AT1A3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PECA1_HUMAN | [view interactions] | High throughput | no | no |
VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TYDP1_HUMAN | [view interactions] | High throughput | no | no |
HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRI55_HUMAN | [view interactions] | High throughput | no | no |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
MVP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PCMD2_HUMAN | [view interactions] | High throughput | no | yes |
PR20E_HUMAN | [view interactions] | High throughput | no | no |
B2CL1_HUMAN | [view interactions] | High throughput | no | yes |
GALT_HUMAN | [view interactions] | High throughput | no | yes |
ZCPW1_HUMAN | [view interactions] | High throughput | no | no |
HNRLL_HUMAN | [view interactions] | High throughput | no | yes |
LASP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ABHDB_HUMAN | [view interactions] | High throughput | no | yes |
MEOX2_HUMAN | [view interactions] | High throughput | no | no |
TF3C2_HUMAN | [view interactions] | High throughput | no | no |
KHDC1_HUMAN | [view interactions] | High throughput | no | no |
GCST_HUMAN | [view interactions] | High throughput | no | yes |
MET15_HUMAN | [view interactions] | High throughput | no | no |
ACTMP_HUMAN | [view interactions] | High throughput | no | no |
MBLC1_HUMAN | [view interactions] | High throughput | no | no |
TRI63_HUMAN | [view interactions] | High throughput | no | no |
NEUL4_HUMAN | [view interactions] | High throughput | no | yes |
CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PD1L1_HUMAN | [view interactions] | High throughput | no | no |
PAR16_HUMAN | [view interactions] | High throughput | no | yes |
GNAI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MICA_HUMAN | [view interactions] | High throughput | no | no |
AR13B_HUMAN | [view interactions] | High throughput | no | yes |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
PODO_HUMAN | [view interactions] | High throughput | no | no |
CAF1A_HUMAN | [view interactions] | High throughput | no | yes |
LNP_HUMAN | [view interactions] | High throughput | no | yes |
ANK1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
S26A6_HUMAN | [view interactions] | High throughput | no | yes |
ERGI3_HUMAN | [view interactions] | High throughput | no | yes |
MPZL1_HUMAN | [view interactions] | High throughput | no | yes |
QKI_HUMAN | [view interactions] | High throughput | no | no |
AT2B2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AT2B4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SLMAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EGLN3_HUMAN | [view interactions] | High throughput | no | no |
PTC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
APEX1_HUMAN | [view interactions] | High throughput | no | yes |
LMBRL_HUMAN | [view interactions] | High throughput | no | no |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
CUL4A_HUMAN | [view interactions] | High throughput | no | no |
DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NUD19_HUMAN | [view interactions] | High throughput | no | no |
ARSL_HUMAN | [view interactions] | High throughput | no | no |
TPST2_HUMAN | [view interactions] | High throughput | no | yes |
CD80_HUMAN | [view interactions] | High throughput | no | no |
PACC1_HUMAN | [view interactions] | High throughput | no | no |
GPR17_HUMAN | [view interactions] | High throughput | no | no |
DPH1_HUMAN | [view interactions] | High throughput | no | yes |
F234A_HUMAN | [view interactions] | High throughput | no | yes |
CABP2_HUMAN | [view interactions] | High throughput | no | no |
NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TSN8_HUMAN | [view interactions] | High throughput | no | no |
HCST_HUMAN | [view interactions] | High throughput | no | no |
S27A2_HUMAN | [view interactions] | High throughput | no | no |
PIGS_HUMAN | [view interactions] | High throughput | no | yes |
BI1_HUMAN | [view interactions] | High throughput | no | yes |
INAVA_HUMAN | [view interactions] | High throughput | no | yes |
CMTD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MFD4A_HUMAN | [view interactions] | High throughput | no | yes |
TMM43_HUMAN | [view interactions] | High throughput | no | no |
CYH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OMA1_HUMAN | [view interactions] | High throughput | no | no |
HS2ST_HUMAN | [view interactions] | High throughput | no | yes |
EP300_HUMAN | [view interactions] | High throughput | no | yes |
RHOQ_HUMAN | [view interactions] | High throughput | no | no |
TOP2A_HUMAN | [view interactions] | High throughput | no | no |
PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BAP1_HUMAN | [view interactions] | High throughput | no | yes |
TRI67_HUMAN | [view interactions] | High throughput | no | no |
RHG24_HUMAN | [view interactions] | High throughput | no | yes |
TOP3B_HUMAN | [view interactions] | High throughput | no | no |
SRPK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LSM4_HUMAN | [view interactions] | High throughput | no | yes |
KPB1_HUMAN | [view interactions] | High throughput | no | yes |