Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NOS1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NOS1_HUMAN
GO:0043169 cation binding 45.4545 4 yes
GO:0046872 metal ion binding 45.4545 5 yes
GO:0043168 anion binding 40.9091 4 yes
GO:0000166 nucleotide binding 38.6364 4 yes
GO:0017076 purine nucleotide binding 38.6364 5 yes
GO:0030554 adenyl nucleotide binding 38.6364 6 yes
GO:0005524 ATP binding 31.8182 5 no
GO:0032555 purine ribonucleotide binding 31.8182 4 no
GO:0032559 adenyl ribonucleotide binding 31.8182 5 no
GO:0035639 purine ribonucleoside triphosphate binding 31.8182 4 no
GO:0019900 kinase binding 27.2727 4 no
GO:0003723 RNA binding 20.4545 4 no
GO:0046914 transition metal ion binding 18.1818 6 yes
GO:0099106 ion channel regulator activity 13.6364 4 yes
GO:0017080 sodium channel regulator activity 9.0909 5 yes
GO:0031406 carboxylic acid binding 9.0909 4 yes
GO:0004517 nitric-oxide synthase activity 4.5455 5 yes
GO:0010181 FMN binding 4.5455 4 yes
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 4.5455 4 yes
GO:0020037 heme binding 4.5455 4 yes
GO:0046870 cadmium ion binding 4.5455 7 yes
GO:0050660 flavin adenine dinucleotide binding 4.5455 5 yes
GO:0050661 NADP binding 4.5455 7 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NOS1_HUMAN
GO:0048522 positive regulation of cellular process 56.8182 4 yes
GO:0060255 regulation of macromolecule metabolic process 56.8182 4 yes
GO:0051049 regulation of transport 54.5455 4 yes
GO:0080090 regulation of primary metabolic process 54.5455 4 yes
GO:0010646 regulation of cell communication 52.2727 4 yes
GO:0031323 regulation of cellular metabolic process 52.2727 4 yes
GO:0009893 positive regulation of metabolic process 45.4545 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 45.4545 5 yes
GO:0009966 regulation of signal transduction 43.1818 4 yes
GO:0048523 negative regulation of cellular process 43.1818 4 yes
GO:0051246 regulation of protein metabolic process 43.1818 5 yes
GO:0031325 positive regulation of cellular metabolic process 38.6364 5 yes
GO:0031399 regulation of protein modification process 38.6364 6 yes
GO:0051247 positive regulation of protein metabolic process 38.6364 6 yes
GO:0009889 regulation of biosynthetic process 36.3636 4 yes
GO:0043269 regulation of monoatomic ion transport 36.3636 5 yes
GO:0010468 regulation of gene expression 34.0909 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 34.0909 5 yes
GO:0010647 positive regulation of cell communication 34.0909 5 yes
GO:0023056 positive regulation of signaling 34.0909 4 yes
GO:0031326 regulation of cellular biosynthetic process 34.0909 5 yes
GO:0034762 regulation of transmembrane transport 34.0909 4 yes
GO:0044057 regulation of system process 34.0909 4 yes
GO:0048584 positive regulation of response to stimulus 34.0909 4 yes
GO:0034765 regulation of monoatomic ion transmembrane transport 31.8182 5 yes
GO:0051050 positive regulation of transport 31.8182 4 yes
GO:1904062 regulation of monoatomic cation transmembrane transport 31.8182 6 yes
GO:0009892 negative regulation of metabolic process 31.8182 4 no
GO:0009967 positive regulation of signal transduction 29.5455 5 yes
GO:0010959 regulation of metal ion transport 29.5455 6 yes
GO:0019220 regulation of phosphate metabolic process 29.5455 6 yes
GO:0031401 positive regulation of protein modification process 29.5455 7 yes
GO:0042325 regulation of phosphorylation 29.5455 7 yes
GO:0051174 regulation of phosphorus metabolic process 29.5455 5 yes
GO:0051128 regulation of cellular component organization 29.5455 4 no
GO:0010605 negative regulation of macromolecule metabolic process 29.5455 5 no
GO:0001932 regulation of protein phosphorylation 27.2727 7 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 27.2727 5 yes
GO:0006796 phosphate-containing compound metabolic process 27.2727 4 no
GO:0022607 cellular component assembly 27.2727 4 no
GO:0031324 negative regulation of cellular metabolic process 27.2727 5 no
GO:0043085 positive regulation of catalytic activity 27.2727 4 no
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 yes
GO:0006355 regulation of DNA-templated transcription 25.0000 7 yes
GO:0008016 regulation of heart contraction 25.0000 6 yes
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 yes
GO:0042327 positive regulation of phosphorylation 25.0000 8 yes
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 yes
GO:0051252 regulation of RNA metabolic process 25.0000 5 yes
GO:0099536 synaptic signaling 25.0000 4 yes
GO:1903522 regulation of blood circulation 25.0000 5 yes
GO:2001141 regulation of RNA biosynthetic process 25.0000 6 yes
GO:1902531 regulation of intracellular signal transduction 25.0000 5 no
GO:0009891 positive regulation of biosynthetic process 22.7273 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 22.7273 6 yes
GO:0031328 positive regulation of cellular biosynthetic process 22.7273 6 yes
GO:0036211 protein modification process 22.7273 4 yes
GO:0043270 positive regulation of monoatomic ion transport 22.7273 5 yes
GO:0043412 macromolecule modification 22.7273 4 yes
GO:0051924 regulation of calcium ion transport 22.7273 7 yes
GO:0060341 regulation of cellular localization 22.7273 4 yes
GO:0051248 negative regulation of protein metabolic process 22.7273 6 no
GO:0006357 regulation of transcription by RNA polymerase II 20.4545 8 yes
GO:0022898 regulation of transmembrane transporter activity 20.4545 4 yes
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 20.4545 5 yes
GO:0090257 regulation of muscle system process 20.4545 5 yes
GO:1903169 regulation of calcium ion transmembrane transport 20.4545 7 yes
GO:0006996 organelle organization 20.4545 4 no
GO:0008104 protein localization 20.4545 4 no
GO:0010243 response to organonitrogen compound 20.4545 4 no
GO:0031400 negative regulation of protein modification process 20.4545 7 no
GO:0043933 protein-containing complex organization 20.4545 4 no
GO:0065003 protein-containing complex assembly 20.4545 5 no
GO:0051726 regulation of cell cycle 20.4545 4 no
GO:0010038 response to metal ion 20.4545 4 no
GO:0006936 muscle contraction 18.1818 4 yes
GO:0006937 regulation of muscle contraction 18.1818 6 yes
GO:0034764 positive regulation of transmembrane transport 18.1818 5 yes
GO:0034767 positive regulation of monoatomic ion transmembrane transport 18.1818 6 yes
GO:0051336 regulation of hydrolase activity 18.1818 4 yes
GO:0099537 trans-synaptic signaling 18.1818 5 yes
GO:0141124 intracellular signaling cassette 18.1818 4 yes
GO:1904064 positive regulation of cation transmembrane transport 18.1818 7 yes
GO:0006942 regulation of striated muscle contraction 15.9091 7 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 15.9091 5 yes
GO:0055117 regulation of cardiac muscle contraction 15.9091 7 yes
GO:1901019 regulation of calcium ion transmembrane transporter activity 15.9091 6 yes
GO:1901565 organonitrogen compound catabolic process 15.9091 4 yes
GO:2001257 regulation of cation channel activity 15.9091 6 yes
GO:0002028 regulation of sodium ion transport 13.6364 7 yes
GO:0003018 vascular process in circulatory system 13.6364 4 yes
GO:0033993 response to lipid 13.6364 4 yes
GO:0051051 negative regulation of transport 13.6364 4 yes
GO:0051254 positive regulation of RNA metabolic process 13.6364 6 yes
GO:0051279 regulation of release of sequestered calcium ion into cytosol 13.6364 5 yes
GO:0051282 regulation of sequestering of calcium ion 13.6364 4 yes
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity 13.6364 6 yes
GO:1902305 regulation of sodium ion transmembrane transport 13.6364 7 yes
GO:0034763 negative regulation of transmembrane transport 11.3636 5 yes
GO:0034766 negative regulation of monoatomic ion transmembrane transport 11.3636 6 yes
GO:0035150 regulation of tube size 11.3636 4 yes
GO:0035296 regulation of tube diameter 11.3636 5 yes
GO:0043271 negative regulation of monoatomic ion transport 11.3636 5 yes
GO:0045893 positive regulation of DNA-templated transcription 11.3636 8 yes
GO:0045944 positive regulation of transcription by RNA polymerase II 11.3636 9 yes
GO:0051926 negative regulation of calcium ion transport 11.3636 6 yes
GO:0097746 blood vessel diameter maintenance 11.3636 5 yes
GO:1902680 positive regulation of RNA biosynthetic process 11.3636 7 yes
GO:1903170 negative regulation of calcium ion transmembrane transport 11.3636 7 yes
GO:1904063 negative regulation of cation transmembrane transport 11.3636 7 yes
GO:0006941 striated muscle contraction 9.0909 5 yes
GO:0019752 carboxylic acid metabolic process 9.0909 5 yes
GO:0033135 regulation of peptidyl-serine phosphorylation 9.0909 8 yes
GO:0036293 response to decreased oxygen levels 9.0909 4 yes
GO:0043266 regulation of potassium ion transport 9.0909 7 yes
GO:0043436 oxoacid metabolic process 9.0909 4 yes
GO:0008277 regulation of G protein-coupled receptor signaling pathway 6.8182 5 yes
GO:0009063 amino acid catabolic process 6.8182 4 yes
GO:0010765 positive regulation of sodium ion transport 6.8182 6 yes
GO:0016054 organic acid catabolic process 6.8182 4 yes
GO:0018193 peptidyl-amino acid modification 6.8182 5 yes
GO:0033138 positive regulation of peptidyl-serine phosphorylation 6.8182 9 yes
GO:0043086 negative regulation of catalytic activity 6.8182 4 yes
GO:0046395 carboxylic acid catabolic process 6.8182 5 yes
GO:0051588 regulation of neurotransmitter transport 6.8182 5 yes
GO:0106070 regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway 6.8182 6 yes
GO:1902307 positive regulation of sodium ion transmembrane transport 6.8182 7 yes
GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel 6.8182 8 yes
GO:0002237 response to molecule of bacterial origin 4.5455 4 yes
GO:0006525 arginine metabolic process 4.5455 5 yes
GO:0006527 arginine catabolic process 4.5455 6 yes
GO:0007263 nitric oxide mediated signal transduction 4.5455 5 yes
GO:0007520 myoblast fusion 4.5455 4 yes
GO:0009064 glutamine family amino acid metabolic process 4.5455 5 yes
GO:0009065 glutamine family amino acid catabolic process 4.5455 6 yes
GO:0010523 negative regulation of calcium ion transport into cytosol 4.5455 4 yes
GO:0017014 protein nitrosylation 4.5455 5 yes
GO:0018119 peptidyl-cysteine S-nitrosylation 4.5455 6 yes
GO:0018198 peptidyl-cysteine modification 4.5455 6 yes
GO:0032496 response to lipopolysaccharide 4.5455 4 yes
GO:0042178 xenobiotic catabolic process 4.5455 4 yes
GO:0042311 vasodilation 4.5455 6 yes
GO:0043267 negative regulation of potassium ion transport 4.5455 6 yes
GO:0045745 positive regulation of G protein-coupled receptor signaling pathway 4.5455 6 yes
GO:0045776 negative regulation of blood pressure 4.5455 4 yes
GO:0051346 negative regulation of hydrolase activity 4.5455 5 yes
GO:0051580 regulation of neurotransmitter uptake 4.5455 6 yes
GO:0051581 negative regulation of neurotransmitter uptake 4.5455 6 yes
GO:0051589 negative regulation of neurotransmitter transport 4.5455 5 yes
GO:0051611 regulation of serotonin uptake 4.5455 7 yes
GO:0051612 negative regulation of serotonin uptake 4.5455 7 yes
GO:0071363 cellular response to growth factor stimulus 4.5455 4 yes
GO:0098735 positive regulation of the force of heart contraction 4.5455 4 yes
GO:0098917 retrograde trans-synaptic signaling 4.5455 6 yes
GO:0098923 retrograde trans-synaptic signaling by soluble gas 4.5455 7 yes
GO:0098924 retrograde trans-synaptic signaling by nitric oxide 4.5455 7 yes
GO:0099163 synaptic signaling by nitric oxide 4.5455 5 yes
GO:0099543 trans-synaptic signaling by soluble gas 4.5455 6 yes
GO:0099548 trans-synaptic signaling by nitric oxide 4.5455 6 yes
GO:0106071 positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway 4.5455 7 yes
GO:0170033 L-amino acid metabolic process 4.5455 5 yes
GO:0170035 L-amino acid catabolic process 4.5455 6 yes
GO:0170039 proteinogenic amino acid metabolic process 4.5455 4 yes
GO:0170040 proteinogenic amino acid catabolic process 4.5455 5 yes
GO:1901605 alpha-amino acid metabolic process 4.5455 4 yes
GO:1901606 alpha-amino acid catabolic process 4.5455 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MAST1_HUMAN [view interactions] Low throughput no yes
DYL1_HUMAN [view entry] [view interactions] Low throughput yes no
SC6A4_HUMAN [view entry] [view interactions] Low throughput yes no
CTBP1_HUMAN [view entry] [view interactions] Low throughput yes yes
AT2B4_HUMAN [view entry] [view interactions] Low throughput yes yes
PFKAM_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
VAC14_HUMAN [view entry] [view interactions] Low throughput yes yes
5HT2B_HUMAN [view interactions] Low throughput no no
ARGI2_HUMAN [view interactions] Low throughput no yes
NMDE1_HUMAN [view entry] [view interactions] Low throughput yes yes
SCN5A_HUMAN [view interactions] Low throughput no no
PGH2_HUMAN [view interactions] Low throughput no no
KKCC1_HUMAN [view entry] [view interactions] Low throughput yes yes
SNTA1_HUMAN [view entry] [view interactions] Low throughput yes no
MYO5A_HUMAN [view entry] [view interactions] Low throughput yes yes
SCN7A_HUMAN [view interactions] Low throughput no no
ADRB3_HUMAN [view interactions] Low throughput no no
PGH1_HUMAN [view interactions] Low throughput no yes
CAPON_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG2_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCD1_HUMAN [view interactions] Low throughput no yes
NOS1_HUMAN [view entry] [view interactions] Low throughput yes yes
ZDH23_HUMAN [view interactions] Low throughput no no
BKRB2_HUMAN [view interactions] Low throughput no yes
PTN6_HUMAN [view interactions] Low throughput no no
CAV3_HUMAN [view interactions] Low throughput no no
CHIP_HUMAN [view entry] [view interactions] Low throughput yes yes
HSP74_HUMAN [view entry] [view interactions] Low throughput yes yes
HS90A_HUMAN [view entry] [view interactions] Low throughput yes yes
NOSIP_HUMAN [view interactions] Low throughput no yes
DMD_HUMAN [view entry] [view interactions] Low throughput yes no
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
AT2B1_HUMAN [view entry] [view interactions] Low throughput yes yes
SOX2_HUMAN [view interactions] Low throughput no yes
PRIO_HUMAN [view entry] [view interactions] Low throughput yes yes
SNTB1_HUMAN [view entry] [view interactions] Low throughput yes yes
SNTB2_HUMAN [view entry] [view interactions] Low throughput yes no
RASD1_HUMAN [view interactions] Low throughput no yes
SYN1_HUMAN [view entry] [view interactions] Low throughput yes no
GEPH_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDZ1_HUMAN [view entry] [view interactions] High throughput yes yes
CKAP4_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
HUWE1_HUMAN [view interactions] High throughput no yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
NMDE2_HUMAN [view entry] [view interactions] High throughput yes no
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
H6ST3_HUMAN [view interactions] High throughput no no
CA226_HUMAN [view interactions] High throughput no yes
DYL2_HUMAN [view entry] [view interactions] High throughput yes no
CSK2B_HUMAN [view entry] [view interactions] High throughput yes yes
NAA10_HUMAN [view interactions] High throughput no yes
DTNB_HUMAN [view entry] [view interactions] High throughput yes no
NOS2_HUMAN [view interactions] High throughput no yes
UTRN_HUMAN [view entry] [view interactions] High throughput yes yes
CUL9_HUMAN [view interactions] High throughput no no
OS9_HUMAN [view interactions] High throughput no yes
ARRD1_HUMAN [view interactions] High throughput no yes
ADCY9_HUMAN [view interactions] High throughput no yes
OTU7A_HUMAN [view interactions] High throughput no no
MTR1A_HUMAN [view interactions] High throughput no no
KCC1A_HUMAN [view entry] [view interactions] High throughput yes yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
ETFB_HUMAN [view entry] [view interactions] High throughput yes yes
PPP5_HUMAN [view entry] [view interactions] High throughput yes yes
DCA11_HUMAN [view interactions] High throughput no yes