CAPON_HUMAN
Evidence for PS localization
Functions
Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CAPON_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 42.8571 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 42.8571 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 42.8571 | 4 | no |
| GO:0005524 | ATP binding | 28.5714 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 28.5714 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 28.5714 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CAPON_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 65.7143 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 60.0000 | 4 | no |
| GO:0051049 | regulation of transport | 51.4286 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 51.4286 | 4 | yes |
| GO:0010646 | regulation of cell communication | 48.5714 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 48.5714 | 4 | yes |
| GO:0071702 | organic substance transport | 48.5714 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 48.5714 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 45.7143 | 5 | yes |
| GO:0031323 | regulation of cellular metabolic process | 45.7143 | 4 | yes |
| GO:0008104 | protein localization | 45.7143 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 45.7143 | 4 | no |
| GO:0071705 | nitrogen compound transport | 45.7143 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 45.7143 | 4 | no |
| GO:0010468 | regulation of gene expression | 42.8571 | 5 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 42.8571 | 4 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 40.0000 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 40.0000 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 37.1429 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 37.1429 | 4 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 37.1429 | 6 | yes |
| GO:0071310 | cellular response to organic substance | 37.1429 | 4 | no |
| GO:0009966 | regulation of signal transduction | 37.1429 | 4 | yes |
| GO:0023056 | positive regulation of signaling | 34.2857 | 4 | yes |
| GO:0015031 | protein transport | 34.2857 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 34.2857 | 5 | no |
| GO:0010941 | regulation of cell death | 34.2857 | 4 | no |
| GO:0006996 | organelle organization | 34.2857 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 31.4286 | 5 | yes |
| GO:0031399 | regulation of protein modification process | 31.4286 | 6 | yes |
| GO:0043085 | positive regulation of catalytic activity | 31.4286 | 4 | yes |
| GO:0006897 | endocytosis | 31.4286 | 5 | no |
| GO:0022607 | cellular component assembly | 31.4286 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 31.4286 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 31.4286 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 31.4286 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 31.4286 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 28.5714 | 5 | yes |
| GO:0031401 | positive regulation of protein modification process | 28.5714 | 7 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 28.5714 | 5 | yes |
| GO:0006886 | intracellular protein transport | 28.5714 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 28.5714 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 28.5714 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 28.5714 | 7 | no |
| GO:0051336 | regulation of hydrolase activity | 28.5714 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 25.7143 | 6 | yes |
| GO:0051050 | positive regulation of transport | 25.7143 | 4 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 25.7143 | 6 | yes |
| GO:0030100 | regulation of endocytosis | 25.7143 | 5 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 25.7143 | 8 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 25.7143 | 6 | no |
| GO:0042327 | positive regulation of phosphorylation | 25.7143 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 25.7143 | 7 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 25.7143 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 22.8571 | 5 | yes |
| GO:0043933 | protein-containing complex organization | 22.8571 | 4 | no |
| GO:0060341 | regulation of cellular localization | 22.8571 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 22.8571 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 22.8571 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 22.8571 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 22.8571 | 4 | no |
| GO:0060548 | negative regulation of cell death | 22.8571 | 5 | no |
| GO:1901699 | cellular response to nitrogen compound | 22.8571 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 22.8571 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 22.8571 | 4 | yes |
| GO:0034762 | regulation of transmembrane transport | 17.1429 | 4 | yes |
| GO:0034765 | regulation of ion transmembrane transport | 17.1429 | 5 | yes |
| GO:0043269 | regulation of ion transport | 17.1429 | 5 | yes |
| GO:1904062 | regulation of cation transmembrane transport | 17.1429 | 6 | yes |
| GO:0007010 | cytoskeleton organization | 17.1429 | 5 | yes |
| GO:0010959 | regulation of metal ion transport | 14.2857 | 6 | yes |
| GO:0022898 | regulation of transmembrane transporter activity | 14.2857 | 4 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 14.2857 | 6 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 14.2857 | 5 | yes |
| GO:0032412 | regulation of ion transmembrane transporter activity | 11.4286 | 5 | yes |
| GO:0044057 | regulation of system process | 11.4286 | 4 | yes |
| GO:0051924 | regulation of calcium ion transport | 11.4286 | 7 | yes |
| GO:1903169 | regulation of calcium ion transmembrane transport | 11.4286 | 7 | yes |
| GO:0034764 | positive regulation of transmembrane transport | 8.5714 | 5 | yes |
| GO:0034767 | positive regulation of ion transmembrane transport | 8.5714 | 6 | yes |
| GO:0043270 | positive regulation of ion transport | 8.5714 | 5 | yes |
| GO:1903522 | regulation of blood circulation | 8.5714 | 5 | yes |
| GO:1904064 | positive regulation of cation transmembrane transport | 8.5714 | 7 | yes |
| GO:2001257 | regulation of cation channel activity | 8.5714 | 6 | yes |
| GO:0032768 | regulation of monooxygenase activity | 5.7143 | 5 | yes |
| GO:0043266 | regulation of potassium ion transport | 5.7143 | 7 | yes |
| GO:0045428 | regulation of nitric oxide biosynthetic process | 5.7143 | 6 | yes |
| GO:0045429 | positive regulation of nitric oxide biosynthetic process | 5.7143 | 7 | yes |
| GO:0051341 | regulation of oxidoreductase activity | 5.7143 | 4 | yes |
| GO:0051353 | positive regulation of oxidoreductase activity | 5.7143 | 5 | yes |
| GO:0060307 | regulation of ventricular cardiac muscle cell membrane repolarization | 5.7143 | 5 | yes |
| GO:0080164 | regulation of nitric oxide metabolic process | 5.7143 | 5 | yes |
| GO:0099623 | regulation of cardiac muscle cell membrane repolarization | 5.7143 | 4 | yes |
| GO:1901019 | regulation of calcium ion transmembrane transporter activity | 5.7143 | 6 | yes |
| GO:1902514 | regulation of calcium ion transmembrane transport via high voltage-gated calcium channel | 5.7143 | 8 | yes |
| GO:1904407 | positive regulation of nitric oxide metabolic process | 5.7143 | 6 | yes |
| GO:0008016 | regulation of heart contraction | 5.7143 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SYN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SYN3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PTPRN_HUMAN | [view interactions] | Low throughput | no | yes |
| RASD1_HUMAN | [view interactions] | Low throughput | no | yes |
| NOS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PLK1_HUMAN | [view interactions] | High throughput | no | yes |
| NKAP_HUMAN | [view interactions] | High throughput | no | yes |
| TP4AP_HUMAN | [view interactions] | High throughput | no | yes |
| GP156_HUMAN | [view interactions] | High throughput | no | no |
| PI42A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EAF1_HUMAN | [view interactions] | High throughput | no | yes |
| MK_HUMAN | [view interactions] | High throughput | no | no |
| SR1IP_HUMAN | [view interactions] | High throughput | no | no |
| PININ_HUMAN | [view interactions] | High throughput | no | yes |
| MS18B_HUMAN | [view interactions] | High throughput | no | no |
| RHEX_HUMAN | [view interactions] | High throughput | no | no |
| DDX41_HUMAN | [view interactions] | High throughput | no | yes |
| H2B2E_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PLAL2_HUMAN | [view interactions] | High throughput | no | no |
| NHP2_HUMAN | [view interactions] | High throughput | no | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| CT455_HUMAN | [view interactions] | High throughput | no | no |
| CT45A_HUMAN | [view interactions] | High throughput | no | no |
| AKND1_HUMAN | [view interactions] | High throughput | no | no |
| KCRM_HUMAN | [view interactions] | High throughput | no | no |
| PNPH_HUMAN | [view interactions] | High throughput | no | no |
| F133A_HUMAN | [view interactions] | High throughput | no | no |
| TRAF4_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRH_HUMAN | [view interactions] | High throughput | no | no |
| EPHA5_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRP2_HUMAN | [view interactions] | High throughput | no | no |
| LRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRP8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RALA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRP4_HUMAN | [view interactions] | High throughput | no | yes |
| TOM40_HUMAN | [view interactions] | High throughput | no | yes |
| RNPS1_HUMAN | [view interactions] | High throughput | no | yes |
| NAF1_HUMAN | [view interactions] | High throughput | no | yes |
| KLC3_HUMAN | [view interactions] | High throughput | no | no |
| ANC2_HUMAN | [view interactions] | High throughput | no | no |
| NKAP1_HUMAN | [view interactions] | High throughput | no | yes |
| NO40_HUMAN | [view interactions] | High throughput | no | yes |
| AK17A_HUMAN | [view interactions] | High throughput | no | no |
| CAMKV_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| BRD2_HUMAN | [view interactions] | High throughput | no | yes |
| BRD3_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| ING5_HUMAN | [view interactions] | High throughput | no | yes |
| PI42C_HUMAN | [view interactions] | High throughput | no | yes |
| ZCH10_HUMAN | [view interactions] | High throughput | no | yes |
| RP9_HUMAN | [view interactions] | High throughput | no | yes |
| CD6_HUMAN | [view interactions] | High throughput | no | no |
| SULF2_HUMAN | [view interactions] | High throughput | no | yes |
| E41L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFPI2_HUMAN | [view interactions] | High throughput | no | no |
| IKBL1_HUMAN | [view interactions] | High throughput | no | no |
| FGF11_HUMAN | [view interactions] | High throughput | no | no |
| PLCD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENTD1_HUMAN | [view interactions] | High throughput | no | no |
| FGF12_HUMAN | [view interactions] | High throughput | no | no |
| FRIL_HUMAN | [view interactions] | High throughput | no | yes |
| SCRIB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MMTA2_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBW1A_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRJ_HUMAN | [view interactions] | High throughput | no | yes |
| MEX3B_HUMAN | [view interactions] | High throughput | no | no |
| SMAP2_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| AUXI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCHP_HUMAN | [view interactions] | Computational | no | yes |
| VANG1_HUMAN | [view interactions] | Computational | no | no |
| PSF3_HUMAN | [view interactions] | Computational | no | yes |
| TRIP6_HUMAN | [view interactions] | Computational | no | yes |
| AJUBA_HUMAN | [view interactions] | Computational | no | yes |
| WTIP_HUMAN | [view interactions] | Computational | no | no |
| LIMD1_HUMAN | [view interactions] | Computational | no | yes |
| ZYX_HUMAN | [view interactions] | Computational | no | no |
| FBLI1_HUMAN | [view interactions] | Computational | no | yes |