CAPON_HUMAN
Evidence for PS localization
Functions
Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CAPON_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 40.0000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 40.0000 | 5 | no |
| GO:0043168 | anion binding | 40.0000 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 37.5000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 37.5000 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 27.5000 | 6 | no |
| GO:0005524 | ATP binding | 25.0000 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 25.0000 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CAPON_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 62.5000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 60.0000 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 52.5000 | 4 | yes |
| GO:0008104 | protein localization | 52.5000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 52.5000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 47.5000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 47.5000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 45.0000 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 45.0000 | 4 | yes |
| GO:0051049 | regulation of transport | 45.0000 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 42.5000 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 42.5000 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 42.5000 | 4 | yes |
| GO:0071702 | organic substance transport | 42.5000 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 40.0000 | 4 | yes |
| GO:0010468 | regulation of gene expression | 40.0000 | 6 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 40.0000 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 40.0000 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 40.0000 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 40.0000 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 40.0000 | 5 | yes |
| GO:0071705 | nitrogen compound transport | 40.0000 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 37.5000 | 5 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 37.5000 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 37.5000 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 35.0000 | 6 | yes |
| GO:0006996 | organelle organization | 32.5000 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 32.5000 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 32.5000 | 5 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 30.0000 | 5 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 30.0000 | 6 | yes |
| GO:0031399 | regulation of protein modification process | 30.0000 | 6 | yes |
| GO:0015031 | protein transport | 30.0000 | 4 | no |
| GO:0098657 | import into cell | 30.0000 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 30.0000 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 27.5000 | 6 | yes |
| GO:0031401 | positive regulation of protein modification process | 27.5000 | 7 | yes |
| GO:0001932 | regulation of protein phosphorylation | 27.5000 | 7 | no |
| GO:0019220 | regulation of phosphate metabolic process | 27.5000 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 27.5000 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 27.5000 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 27.5000 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 25.0000 | 6 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 25.0000 | 8 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 25.0000 | 6 | no |
| GO:0042327 | positive regulation of phosphorylation | 25.0000 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 25.0000 | 7 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 25.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 25.0000 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 22.5000 | 7 | yes |
| GO:0043085 | positive regulation of catalytic activity | 22.5000 | 4 | yes |
| GO:0006886 | intracellular protein transport | 22.5000 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 22.5000 | 4 | no |
| GO:0030030 | cell projection organization | 22.5000 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 22.5000 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 22.5000 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 22.5000 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 22.5000 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.5000 | 5 | no |
| GO:0051336 | regulation of hydrolase activity | 22.5000 | 4 | no |
| GO:0060341 | regulation of cellular localization | 22.5000 | 4 | no |
| GO:0034762 | regulation of transmembrane transport | 17.5000 | 4 | yes |
| GO:0051050 | positive regulation of transport | 17.5000 | 4 | yes |
| GO:0022898 | regulation of transmembrane transporter activity | 15.0000 | 4 | yes |
| GO:0007010 | cytoskeleton organization | 12.5000 | 5 | yes |
| GO:0010959 | regulation of metal ion transport | 12.5000 | 6 | yes |
| GO:0032412 | regulation of monoatomic ion transmembrane transporter activity | 12.5000 | 5 | yes |
| GO:0034765 | regulation of monoatomic ion transmembrane transport | 12.5000 | 5 | yes |
| GO:0043269 | regulation of monoatomic ion transport | 12.5000 | 5 | yes |
| GO:0044057 | regulation of system process | 12.5000 | 4 | yes |
| GO:1904062 | regulation of monoatomic cation transmembrane transport | 12.5000 | 6 | yes |
| GO:0051924 | regulation of calcium ion transport | 10.0000 | 7 | yes |
| GO:1903169 | regulation of calcium ion transmembrane transport | 10.0000 | 7 | yes |
| GO:0034764 | positive regulation of transmembrane transport | 7.5000 | 5 | yes |
| GO:0034767 | positive regulation of monoatomic ion transmembrane transport | 7.5000 | 6 | yes |
| GO:0043270 | positive regulation of monoatomic ion transport | 7.5000 | 5 | yes |
| GO:1904064 | positive regulation of cation transmembrane transport | 7.5000 | 7 | yes |
| GO:0008016 | regulation of heart contraction | 5.0000 | 6 | yes |
| GO:0032768 | regulation of monooxygenase activity | 5.0000 | 5 | yes |
| GO:0043266 | regulation of potassium ion transport | 5.0000 | 7 | yes |
| GO:0051341 | regulation of oxidoreductase activity | 5.0000 | 4 | yes |
| GO:0051353 | positive regulation of oxidoreductase activity | 5.0000 | 5 | yes |
| GO:0060307 | regulation of ventricular cardiac muscle cell membrane repolarization | 5.0000 | 5 | yes |
| GO:0098974 | postsynaptic actin cytoskeleton organization | 5.0000 | 4 | yes |
| GO:0099188 | postsynaptic cytoskeleton organization | 5.0000 | 6 | yes |
| GO:0099623 | regulation of cardiac muscle cell membrane repolarization | 5.0000 | 4 | yes |
| GO:1901019 | regulation of calcium ion transmembrane transporter activity | 5.0000 | 6 | yes |
| GO:1902514 | regulation of calcium ion transmembrane transport via high voltage-gated calcium channel | 5.0000 | 8 | yes |
| GO:1903522 | regulation of blood circulation | 5.0000 | 5 | yes |
| GO:2001257 | regulation of cation channel activity | 5.0000 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NOS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SYN3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PTPRN_HUMAN | [view interactions] | Low throughput | no | yes |
| RASD1_HUMAN | [view interactions] | Low throughput | no | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RALA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRP4_HUMAN | [view interactions] | High throughput | no | yes |
| TOM40_HUMAN | [view interactions] | High throughput | no | yes |
| RNPS1_HUMAN | [view interactions] | High throughput | no | yes |
| NAF1_HUMAN | [view interactions] | High throughput | no | yes |
| KLC3_HUMAN | [view interactions] | High throughput | no | no |
| ANC2_HUMAN | [view interactions] | High throughput | no | no |
| NKAP1_HUMAN | [view interactions] | High throughput | no | yes |
| ZCC17_HUMAN | [view interactions] | High throughput | no | yes |
| AK17A_HUMAN | [view interactions] | High throughput | no | no |
| CAMKV_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| BRD2_HUMAN | [view interactions] | High throughput | no | yes |
| BRD3_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| ING5_HUMAN | [view interactions] | High throughput | no | yes |
| PI42C_HUMAN | [view interactions] | High throughput | no | yes |
| ZCH10_HUMAN | [view interactions] | High throughput | no | yes |
| RP9_HUMAN | [view interactions] | High throughput | no | yes |
| CD6_HUMAN | [view interactions] | High throughput | no | no |
| SULF2_HUMAN | [view interactions] | High throughput | no | yes |
| E41L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFPI2_HUMAN | [view interactions] | High throughput | no | no |
| IKBL1_HUMAN | [view interactions] | High throughput | no | no |
| FGF11_HUMAN | [view interactions] | High throughput | no | no |
| PLCD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENTD1_HUMAN | [view interactions] | High throughput | no | no |
| FGF12_HUMAN | [view interactions] | High throughput | no | no |
| FRIL_HUMAN | [view interactions] | High throughput | no | yes |
| SCRIB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MMTA2_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| AATF_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBW1A_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRJ_HUMAN | [view interactions] | High throughput | no | yes |
| MEX3B_HUMAN | [view interactions] | High throughput | no | no |
| SMAP2_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| AUXI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLK1_HUMAN | [view interactions] | High throughput | no | yes |
| NKAP_HUMAN | [view interactions] | High throughput | no | yes |
| TP4AP_HUMAN | [view interactions] | High throughput | no | yes |
| GP156_HUMAN | [view interactions] | High throughput | no | no |
| PI42A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EAF1_HUMAN | [view interactions] | High throughput | no | yes |
| MK_HUMAN | [view interactions] | High throughput | no | no |
| SR1IP_HUMAN | [view interactions] | High throughput | no | no |
| PININ_HUMAN | [view interactions] | High throughput | no | yes |
| MS18B_HUMAN | [view interactions] | High throughput | no | no |
| DDX41_HUMAN | [view interactions] | High throughput | no | yes |
| RHEX_HUMAN | [view interactions] | High throughput | no | no |
| H2B2E_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PLAL2_HUMAN | [view interactions] | High throughput | no | no |
| NHP2_HUMAN | [view interactions] | High throughput | no | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| CT455_HUMAN | [view interactions] | High throughput | no | no |
| CT45A_HUMAN | [view interactions] | High throughput | no | no |
| AKND1_HUMAN | [view interactions] | High throughput | no | no |
| KCRM_HUMAN | [view interactions] | High throughput | no | no |
| PNPH_HUMAN | [view interactions] | High throughput | no | no |
| F133A_HUMAN | [view interactions] | High throughput | no | no |
| TRAF4_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPRH_HUMAN | [view interactions] | High throughput | no | no |
| EPHA5_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCNK3_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRP2_HUMAN | [view interactions] | High throughput | no | no |
| LRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRP8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |