SCRIB_HUMAN
Evidence for PS localization
Functions
Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production . Most probably functions in the establishment of apico-basal cell polarity (PubMed, PubMed). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed, PubMed). May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling (PubMed, PubMed). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed). Functions as an activator of Rac GTPase activity. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 454 | Pro | Ser | Neuraltubedefects(NTD) | - |
| 1535 | Arg | Gln | Neuraltubedefects(NTD) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SCRIB_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 37.5000 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 37.5000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 37.5000 | 4 | no |
| GO:0019900 | kinase binding | 26.7857 | 4 | no |
| GO:0046872 | metal ion binding | 25.0000 | 4 | no |
| GO:0019901 | protein kinase binding | 24.1071 | 5 | no |
| GO:0005524 | ATP binding | 22.3214 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 22.3214 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 22.3214 | 5 | no |
| GO:0045296 | cadherin binding | 12.5000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SCRIB_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 70.5357 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 53.5714 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 51.7857 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 50.8929 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 50.8929 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 49.1071 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 48.2143 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 47.3214 | 4 | no |
| GO:0010646 | regulation of cell communication | 46.4286 | 4 | no |
| GO:0009966 | regulation of signal transduction | 42.8571 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 41.0714 | 5 | yes |
| GO:0010468 | regulation of gene expression | 40.1786 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 38.3929 | 5 | yes |
| GO:0022607 | cellular component assembly | 36.6071 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 36.6071 | 5 | no |
| GO:0051049 | regulation of transport | 36.6071 | 4 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 35.7143 | 5 | no |
| GO:0006996 | organelle organization | 35.7143 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 32.1429 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 32.1429 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 32.1429 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 32.1429 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 32.1429 | 4 | no |
| GO:0033043 | regulation of organelle organization | 32.1429 | 5 | no |
| GO:0010941 | regulation of cell death | 32.1429 | 4 | yes |
| GO:0042325 | regulation of phosphorylation | 31.2500 | 7 | no |
| GO:0023056 | positive regulation of signaling | 30.3571 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 29.4643 | 5 | no |
| GO:0008104 | protein localization | 29.4643 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 28.5714 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 28.5714 | 5 | yes |
| GO:0043085 | positive regulation of catalytic activity | 28.5714 | 4 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 27.6786 | 6 | no |
| GO:0009892 | negative regulation of metabolic process | 27.6786 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 27.6786 | 6 | yes |
| GO:0031399 | regulation of protein modification process | 26.7857 | 6 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.7857 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 26.7857 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 26.7857 | 5 | no |
| GO:0030030 | cell projection organization | 26.7857 | 4 | yes |
| GO:0036211 | protein modification process | 25.8929 | 4 | no |
| GO:0043412 | macromolecule modification | 25.8929 | 4 | no |
| GO:0060341 | regulation of cellular localization | 25.0000 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 25.0000 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 24.1071 | 5 | no |
| GO:0051338 | regulation of transferase activity | 24.1071 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 24.1071 | 5 | no |
| GO:0007010 | cytoskeleton organization | 24.1071 | 5 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 23.2143 | 6 | no |
| GO:0042327 | positive regulation of phosphorylation | 23.2143 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 23.2143 | 7 | no |
| GO:0071310 | cellular response to organic substance | 23.2143 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 23.2143 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 23.2143 | 6 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 23.2143 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 23.2143 | 4 | yes |
| GO:0030155 | regulation of cell adhesion | 23.2143 | 4 | yes |
| GO:0071702 | organic substance transport | 23.2143 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 22.3214 | 7 | no |
| GO:0032880 | regulation of protein localization | 22.3214 | 5 | no |
| GO:0034330 | cell junction organization | 22.3214 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 22.3214 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 22.3214 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 21.4286 | 7 | no |
| GO:0009894 | regulation of catabolic process | 21.4286 | 4 | no |
| GO:2000145 | regulation of cell motility | 21.4286 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 21.4286 | 6 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 20.5357 | 5 | yes |
| GO:0043549 | regulation of kinase activity | 20.5357 | 5 | no |
| GO:0030334 | regulation of cell migration | 20.5357 | 5 | no |
| GO:0051336 | regulation of hydrolase activity | 18.7500 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 18.7500 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 17.8571 | 4 | yes |
| GO:0051726 | regulation of cell cycle | 16.9643 | 4 | yes |
| GO:0010942 | positive regulation of cell death | 16.0714 | 5 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 16.0714 | 4 | yes |
| GO:0043065 | positive regulation of apoptotic process | 15.1786 | 7 | yes |
| GO:0043068 | positive regulation of programmed cell death | 15.1786 | 6 | yes |
| GO:0031175 | neuron projection development | 14.2857 | 6 | yes |
| GO:0051345 | positive regulation of hydrolase activity | 14.2857 | 5 | yes |
| GO:0015031 | protein transport | 13.3929 | 4 | yes |
| GO:0006915 | apoptotic process | 12.5000 | 4 | yes |
| GO:0008285 | negative regulation of cell population proliferation | 12.5000 | 5 | yes |
| GO:0002009 | morphogenesis of an epithelium | 11.6071 | 4 | yes |
| GO:0050865 | regulation of cell activation | 11.6071 | 4 | yes |
| GO:0072657 | protein localization to membrane | 10.7143 | 4 | yes |
| GO:0006897 | endocytosis | 10.7143 | 5 | yes |
| GO:0022407 | regulation of cell-cell adhesion | 10.7143 | 5 | yes |
| GO:0001817 | regulation of cytokine production | 9.8214 | 4 | yes |
| GO:0002694 | regulation of leukocyte activation | 9.8214 | 4 | yes |
| GO:0006886 | intracellular protein transport | 9.8214 | 4 | yes |
| GO:0043087 | regulation of GTPase activity | 9.8214 | 5 | yes |
| GO:0007162 | negative regulation of cell adhesion | 8.9286 | 5 | yes |
| GO:0043547 | positive regulation of GTPase activity | 8.9286 | 6 | yes |
| GO:0051249 | regulation of lymphocyte activation | 8.9286 | 5 | yes |
| GO:0070663 | regulation of leukocyte proliferation | 8.9286 | 5 | yes |
| GO:1902414 | protein localization to cell junction | 8.0357 | 5 | yes |
| GO:0030100 | regulation of endocytosis | 8.0357 | 5 | yes |
| GO:0033365 | protein localization to organelle | 8.0357 | 5 | yes |
| GO:0035088 | establishment or maintenance of apical/basal cell polarity | 8.0357 | 4 | yes |
| GO:0050863 | regulation of T cell activation | 8.0357 | 6 | yes |
| GO:0030855 | epithelial cell differentiation | 7.1429 | 4 | yes |
| GO:0032944 | regulation of mononuclear cell proliferation | 7.1429 | 6 | yes |
| GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity | 7.1429 | 5 | yes |
| GO:0050670 | regulation of lymphocyte proliferation | 7.1429 | 6 | yes |
| GO:0072659 | protein localization to plasma membrane | 6.2500 | 5 | yes |
| GO:0150105 | protein localization to cell-cell junction | 6.2500 | 6 | yes |
| GO:1903037 | regulation of leukocyte cell-cell adhesion | 6.2500 | 6 | yes |
| GO:1990778 | protein localization to cell periphery | 6.2500 | 5 | yes |
| GO:0002683 | negative regulation of immune system process | 6.2500 | 4 | yes |
| GO:0007346 | regulation of mitotic cell cycle | 6.2500 | 5 | yes |
| GO:0060562 | epithelial tube morphogenesis | 6.2500 | 4 | yes |
| GO:0072594 | establishment of protein localization to organelle | 5.3571 | 4 | yes |
| GO:0090630 | activation of GTPase activity | 5.3571 | 7 | yes |
| GO:0001819 | positive regulation of cytokine production | 5.3571 | 5 | yes |
| GO:0022408 | negative regulation of cell-cell adhesion | 5.3571 | 6 | yes |
| GO:0042129 | regulation of T cell proliferation | 5.3571 | 7 | yes |
| GO:0043113 | receptor clustering | 5.3571 | 5 | yes |
| GO:0045786 | negative regulation of cell cycle | 5.3571 | 5 | yes |
| GO:0050866 | negative regulation of cell activation | 5.3571 | 5 | yes |
| GO:0002695 | negative regulation of leukocyte activation | 4.4643 | 5 | yes |
| GO:0016197 | endosomal transport | 4.4643 | 4 | yes |
| GO:0030859 | polarized epithelial cell differentiation | 4.4643 | 5 | yes |
| GO:0032945 | negative regulation of mononuclear cell proliferation | 4.4643 | 7 | yes |
| GO:0045930 | negative regulation of mitotic cell cycle | 4.4643 | 6 | yes |
| GO:0048259 | regulation of receptor-mediated endocytosis | 4.4643 | 6 | yes |
| GO:0050672 | negative regulation of lymphocyte proliferation | 4.4643 | 7 | yes |
| GO:0051250 | negative regulation of lymphocyte activation | 4.4643 | 6 | yes |
| GO:0070664 | negative regulation of leukocyte proliferation | 4.4643 | 6 | yes |
| GO:0071896 | protein localization to adherens junction | 3.5714 | 7 | yes |
| GO:0090150 | establishment of protein localization to membrane | 3.5714 | 4 | yes |
| GO:0098876 | vesicle-mediated transport to the plasma membrane | 3.5714 | 4 | yes |
| GO:1903038 | negative regulation of leukocyte cell-cell adhesion | 3.5714 | 7 | yes |
| GO:0002090 | regulation of receptor internalization | 3.5714 | 7 | yes |
| GO:0035089 | establishment of apical/basal cell polarity | 3.5714 | 5 | yes |
| GO:0035418 | protein localization to synapse | 3.5714 | 6 | yes |
| GO:0042060 | wound healing | 3.5714 | 4 | yes |
| GO:0042130 | negative regulation of T cell proliferation | 3.5714 | 8 | yes |
| GO:0050868 | negative regulation of T cell activation | 3.5714 | 7 | yes |
| GO:0061162 | establishment of monopolar cell polarity | 3.5714 | 4 | yes |
| GO:0099003 | vesicle-mediated transport in synapse | 2.6786 | 5 | yes |
| GO:0140238 | presynaptic endocytosis | 2.6786 | 4 | yes |
| GO:1903539 | protein localization to postsynaptic membrane | 2.6786 | 5 | yes |
| GO:0001843 | neural tube closure | 2.6786 | 5 | yes |
| GO:0001919 | regulation of receptor recycling | 2.6786 | 4 | yes |
| GO:0032456 | endocytic recycling | 2.6786 | 5 | yes |
| GO:0032649 | regulation of interferon-gamma production | 2.6786 | 5 | yes |
| GO:0032729 | positive regulation of interferon-gamma production | 2.6786 | 6 | yes |
| GO:0036010 | protein localization to endosome | 2.6786 | 6 | yes |
| GO:0048488 | synaptic vesicle endocytosis | 2.6786 | 5 | yes |
| GO:0060606 | tube closure | 2.6786 | 4 | yes |
| GO:0062237 | protein localization to postsynapse | 2.6786 | 7 | yes |
| GO:0098877 | neurotransmitter receptor transport to plasma membrane | 1.7857 | 4 | yes |
| GO:0098887 | neurotransmitter receptor transport, endosome to postsynaptic membrane | 1.7857 | 5 | yes |
| GO:0098968 | neurotransmitter receptor transport postsynaptic membrane to endosome | 1.7857 | 4 | yes |
| GO:0098969 | neurotransmitter receptor transport to postsynaptic membrane | 1.7857 | 4 | yes |
| GO:0099638 | endosome to plasma membrane protein transport | 1.7857 | 5 | yes |
| GO:0099639 | neurotransmitter receptor transport, endosome to plasma membrane | 1.7857 | 5 | yes |
| GO:1902742 | apoptotic process involved in development | 1.7857 | 5 | yes |
| GO:1902946 | protein localization to early endosome | 1.7857 | 7 | yes |
| GO:1903540 | establishment of protein localization to postsynaptic membrane | 1.7857 | 5 | yes |
| GO:0001767 | establishment of lymphocyte polarity | 1.7857 | 4 | yes |
| GO:0001768 | establishment of T cell polarity | 1.7857 | 5 | yes |
| GO:0001921 | positive regulation of receptor recycling | 1.7857 | 5 | yes |
| GO:0008347 | glial cell migration | 1.7857 | 4 | yes |
| GO:0021747 | cochlear nucleus development | 1.7857 | 4 | yes |
| GO:0043615 | astrocyte cell migration | 1.7857 | 5 | yes |
| GO:0046006 | regulation of activated T cell proliferation | 1.7857 | 8 | yes |
| GO:0046007 | negative regulation of activated T cell proliferation | 1.7857 | 9 | yes |
| GO:0050918 | positive chemotaxis | 1.7857 | 4 | yes |
| GO:0060088 | auditory receptor cell stereocilium organization | 1.7857 | 8 | yes |
| GO:0060122 | inner ear receptor cell stereocilium organization | 1.7857 | 7 | yes |
| GO:0060561 | apoptotic process involved in morphogenesis | 1.7857 | 6 | yes |
| GO:0060603 | mammary gland duct morphogenesis | 1.7857 | 5 | yes |
| GO:0061951 | establishment of protein localization to plasma membrane | 1.7857 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in SCRIB_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 3.5714 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 3.5714 | 5 | no |
| DOID:114 | heart disease | 3.5714 | 3 | no |
| DOID:2843 | long QT syndrome | 1.7857 | 6 | no |
| DOID:0111962 | combined immunodeficiency | 1.7857 | 4 | no |
| DOID:612 | primary immunodeficiency disease | 1.7857 | 3 | no |
| DOID:574 | peripheral nervous system disease | 1.7857 | 3 | no |
| DOID:870 | neuropathy | 1.7857 | 4 | no |
| DOID:0050686 | organ system cancer | 1.7857 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| VANG2_HUMAN | [view interactions] | Low throughput | no | no |
| MUSK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ARHG7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PKP4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ADA1D_HUMAN | [view interactions] | Low throughput | no | no |
| MK12_HUMAN | [view interactions] | Low throughput | no | no |
| GCYA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| S6A12_HUMAN | [view interactions] | Low throughput | no | no |
| KPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TRIP6_HUMAN | [view interactions] | Low throughput | no | yes |
| CRCM_HUMAN | [view interactions] | Low throughput | no | no |
| TSHR_HUMAN | [view interactions] | Low throughput | no | no |
| ZO2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GIT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CRTAM_HUMAN | [view interactions] | Low throughput | no | no |
| PHLP1_HUMAN | [view interactions] | Low throughput | no | yes |
| PHLP2_HUMAN | [view interactions] | Low throughput | no | yes |
| HGFL_HUMAN | [view interactions] | Low throughput | no | no |
| MARK4_HUMAN | [view interactions] | Low throughput | no | yes |
| KS6A2_HUMAN | [view interactions] | Low throughput | no | yes |
| ARHGQ_HUMAN | [view interactions] | Low throughput | no | yes |
| APC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| UBE3A_HUMAN | [view interactions] | Low throughput | no | yes |
| MK03_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KS6A1_HUMAN | [view interactions] | Low throughput | no | yes |
| SCRIB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| WWTR1_HUMAN | [view interactions] | Low throughput | no | yes |
| LATS1_HUMAN | [view interactions] | Low throughput | no | yes |
| MARK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CADH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MK01_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TANC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EPHA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EPHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STYK1_HUMAN | [view interactions] | High throughput | no | yes |
| CPNE8_HUMAN | [view interactions] | High throughput | no | yes |
| AT2B2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAKD5_HUMAN | [view interactions] | High throughput | no | yes |
| F163B_HUMAN | [view interactions] | High throughput | no | yes |
| MELT_HUMAN | [view interactions] | High throughput | no | yes |
| WTIP_HUMAN | [view interactions] | High throughput | no | no |
| AT2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRFR1_HUMAN | [view interactions] | High throughput | no | yes |
| FRPD4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLTR2_HUMAN | [view interactions] | High throughput | no | no |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| PRDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBCD8_HUMAN | [view interactions] | High throughput | no | yes |
| 5HT2C_HUMAN | [view interactions] | High throughput | no | no |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FRPD1_HUMAN | [view interactions] | High throughput | no | yes |
| MOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OR5F1_HUMAN | [view interactions] | High throughput | no | no |
| CSN1_HUMAN | [view interactions] | High throughput | no | no |
| ASND1_HUMAN | [view interactions] | High throughput | no | yes |
| PD2R_HUMAN | [view interactions] | High throughput | no | no |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HTR5B_HUMAN | [view interactions] | High throughput | no | yes |
| XKR4_HUMAN | [view interactions] | High throughput | no | no |
| UT1_HUMAN | [view interactions] | High throughput | no | no |
| S4A7_HUMAN | [view interactions] | High throughput | no | no |
| MOT4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHOC2_HUMAN | [view interactions] | High throughput | no | yes |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| LGR4_HUMAN | [view interactions] | High throughput | no | yes |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| CNPY3_HUMAN | [view interactions] | High throughput | no | yes |
| CL18A_HUMAN | [view interactions] | High throughput | no | no |
| RBM23_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT44_HUMAN | [view interactions] | High throughput | no | yes |
| PPR3A_HUMAN | [view interactions] | High throughput | no | no |
| IL1R2_HUMAN | [view interactions] | High throughput | no | no |
| LRC27_HUMAN | [view interactions] | High throughput | no | yes |
| ZN263_HUMAN | [view interactions] | High throughput | no | yes |
| LRIG1_HUMAN | [view interactions] | High throughput | no | yes |
| P4HA3_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| RN146_HUMAN | [view interactions] | High throughput | no | yes |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| R144A_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| ARHGF_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| BRD1_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| CIC_HUMAN | [view interactions] | High throughput | no | yes |
| ZN317_HUMAN | [view interactions] | High throughput | no | yes |
| SETD2_HUMAN | [view interactions] | High throughput | no | yes |
| ZN777_HUMAN | [view interactions] | High throughput | no | yes |
| GIT2_HUMAN | [view interactions] | High throughput | no | yes |
| SLTM_HUMAN | [view interactions] | High throughput | no | yes |
| RNPS1_HUMAN | [view interactions] | High throughput | no | yes |
| DCNL2_HUMAN | [view interactions] | High throughput | no | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZN697_HUMAN | [view interactions] | High throughput | no | no |
| ZN316_HUMAN | [view interactions] | High throughput | no | no |
| ZN768_HUMAN | [view interactions] | High throughput | no | yes |
| PPHLN_HUMAN | [view interactions] | High throughput | no | yes |
| ZKSC8_HUMAN | [view interactions] | High throughput | no | yes |
| KCNA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN446_HUMAN | [view interactions] | High throughput | no | yes |
| LRRC1_HUMAN | [view interactions] | High throughput | no | yes |
| CA226_HUMAN | [view interactions] | High throughput | no | yes |
| LRC40_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEK1_HUMAN | [view interactions] | High throughput | no | yes |
| KIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| I2BP2_HUMAN | [view interactions] | High throughput | no | yes |
| ZN628_HUMAN | [view interactions] | High throughput | no | no |
| AAKB2_HUMAN | [view interactions] | High throughput | no | yes |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| HME1_HUMAN | [view interactions] | High throughput | no | no |
| ZN638_HUMAN | [view interactions] | High throughput | no | yes |
| C170B_HUMAN | [view interactions] | High throughput | no | yes |
| ZN483_HUMAN | [view interactions] | High throughput | no | no |
| PATZ1_HUMAN | [view interactions] | High throughput | no | yes |
| I2BPL_HUMAN | [view interactions] | High throughput | no | yes |
| SGT1_HUMAN | [view interactions] | High throughput | no | no |
| ZN592_HUMAN | [view interactions] | High throughput | no | yes |
| ZN449_HUMAN | [view interactions] | High throughput | no | no |
| ZN219_HUMAN | [view interactions] | High throughput | no | yes |
| ZNF7_HUMAN | [view interactions] | High throughput | no | yes |
| CAPON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| I2BP1_HUMAN | [view interactions] | High throughput | no | yes |
| SHKB1_HUMAN | [view interactions] | High throughput | no | yes |
| FP100_HUMAN | [view interactions] | High throughput | no | yes |
| CPVL_HUMAN | [view interactions] | High throughput | no | no |
| PI42A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLH13_HUMAN | [view interactions] | High throughput | no | no |
| ARHG8_HUMAN | [view interactions] | High throughput | no | yes |
| SF3B3_HUMAN | [view interactions] | High throughput | no | yes |
| KCNA5_HUMAN | [view interactions] | High throughput | no | no |
| PI42B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VWCE_HUMAN | [view interactions] | High throughput | no | no |
| TRAF7_HUMAN | [view interactions] | High throughput | no | yes |
| DNM1L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLHL9_HUMAN | [view interactions] | High throughput | no | no |
| AAKG2_HUMAN | [view interactions] | High throughput | no | yes |
| NXPE2_HUMAN | [view interactions] | High throughput | no | no |
| AAKG1_HUMAN | [view interactions] | High throughput | no | no |
| CTND2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZSWM1_HUMAN | [view interactions] | High throughput | no | yes |
| LRSM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATD2B_HUMAN | [view interactions] | High throughput | no | yes |
| LMO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PI42C_HUMAN | [view interactions] | High throughput | no | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| SO1C1_HUMAN | [view interactions] | High throughput | no | no |
| SIR6_HUMAN | [view interactions] | High throughput | no | yes |
| RBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCNA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PIGR_HUMAN | [view interactions] | High throughput | no | no |
| ADA22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCNB2_HUMAN | [view interactions] | High throughput | no | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MRP4_HUMAN | [view interactions] | High throughput | no | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLK2_HUMAN | [view interactions] | High throughput | no | no |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANR50_HUMAN | [view interactions] | High throughput | no | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| S15A5_HUMAN | [view interactions] | High throughput | no | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| F189B_HUMAN | [view interactions] | High throughput | no | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RPR1B_HUMAN | [view interactions] | High throughput | no | yes |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| TMIG1_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| STAR8_HUMAN | [view interactions] | High throughput | no | yes |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| ZN563_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| S4A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| NR2E1_HUMAN | [view interactions] | High throughput | no | yes |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| LNX1_HUMAN | [view interactions] | High throughput | no | yes |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| KCJ12_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| KCNJ4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EXOSX_HUMAN | [view interactions] | High throughput | no | yes |
| KS6A3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| TS101_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CENPC_HUMAN | [view interactions] | High throughput | no | no |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| SLX4_HUMAN | [view interactions] | High throughput | no | yes |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| DMWD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| E41LA_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAA11_HUMAN | [view interactions] | High throughput | no | no |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NU107_HUMAN | [view interactions] | High throughput | no | no |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VPS11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPTC2_HUMAN | [view interactions] | High throughput | no | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGS1_HUMAN | [view interactions] | High throughput | no | yes |
| AFAD_HUMAN | [view interactions] | High throughput | no | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| PARD3_HUMAN | [view interactions] | High throughput | no | yes |
| KI67_HUMAN | [view interactions] | High throughput | no | no |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| ARHGG_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| RNF43_HUMAN | [view interactions] | High throughput | no | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| TBB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MB212_HUMAN | [view interactions] | High throughput | no | no |
| RN213_HUMAN | [view interactions] | High throughput | no | yes |
| SNTA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASA1_HUMAN | [view interactions] | High throughput | no | yes |
| SH2B1_HUMAN | [view interactions] | High throughput | no | yes |
| VAC14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRIPB_HUMAN | [view interactions] | High throughput | no | yes |
| GELS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| G6PI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P4HA1_HUMAN | [view interactions] | High throughput | no | yes |
| DESP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYIM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPP2_HUMAN | [view interactions] | High throughput | no | yes |
| RALB_HUMAN | [view interactions] | High throughput | no | no |
| CELF1_HUMAN | [view interactions] | High throughput | no | yes |
| RM38_HUMAN | [view interactions] | High throughput | no | yes |
| APOB_HUMAN | [view interactions] | High throughput | no | no |
| CHERP_HUMAN | [view interactions] | High throughput | no | no |
| VAV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLK3_HUMAN | [view interactions] | High throughput | no | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| C5AR2_HUMAN | [view interactions] | High throughput | no | yes |
| M3K3_HUMAN | [view interactions] | High throughput | no | no |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCNL1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| FOXB1_HUMAN | [view interactions] | High throughput | no | no |
| FOXE1_HUMAN | [view interactions] | High throughput | no | no |
| FOXG1_HUMAN | [view interactions] | High throughput | no | no |
| FOXH1_HUMAN | [view interactions] | High throughput | no | no |
| FOXL1_HUMAN | [view interactions] | High throughput | no | no |
| FOXK1_HUMAN | [view interactions] | High throughput | no | yes |
| ARHG6_HUMAN | [view interactions] | High throughput | no | no |
| UTRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DTNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| FBF1_HUMAN | [view interactions] | High throughput | no | no |
| CEP19_HUMAN | [view interactions] | High throughput | no | no |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| MED4_HUMAN | [view interactions] | High throughput | no | yes |
| KCNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYRK2_HUMAN | [view interactions] | High throughput | no | yes |
| DLG2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DLG5_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| L2GL1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| L2GL2_HUMAN | [view interactions] | Computational | no | yes |
| DLG1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RASM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DLG3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| FZD3_HUMAN | [view interactions] | Computational | no | yes |
| VANG1_HUMAN | [view interactions] | Computational | no | no |