SCRIB_HUMAN
Evidence for PS localization
Functions
Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production . Most probably functions in the establishment of apico-basal cell polarity (PubMed, PubMed). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed, PubMed). May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling (PubMed, PubMed). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed). Functions as an activator of Rac GTPase activity. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 454 | Pro | Ser | Neuraltubedefects(NTD) | - |
| 1535 | Arg | Gln | Neuraltubedefects(NTD) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SCRIB_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 41.8605 | 4 | no |
| GO:0000166 | nucleotide binding | 37.9845 | 4 | no |
| GO:0017076 | purine nucleotide binding | 37.2093 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 36.4341 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 36.4341 | 4 | no |
| GO:0043169 | cation binding | 28.6822 | 4 | no |
| GO:0046872 | metal ion binding | 28.6822 | 5 | no |
| GO:0019900 | kinase binding | 24.8062 | 4 | no |
| GO:0019901 | protein kinase binding | 24.0310 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 24.0310 | 6 | no |
| GO:0005524 | ATP binding | 23.2558 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 23.2558 | 5 | no |
| GO:0045296 | cadherin binding | 13.1783 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SCRIB_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 69.7674 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 58.1395 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 57.3643 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 55.8140 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 54.2636 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 50.3876 | 4 | no |
| GO:0010646 | regulation of cell communication | 49.6124 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 47.2868 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 46.5116 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 46.5116 | 5 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 45.7364 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 44.9612 | 4 | no |
| GO:0010468 | regulation of gene expression | 44.9612 | 6 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 42.6357 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 41.0853 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 37.2093 | 5 | no |
| GO:0022607 | cellular component assembly | 37.2093 | 4 | no |
| GO:0051049 | regulation of transport | 37.2093 | 4 | yes |
| GO:0006996 | organelle organization | 36.4341 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 34.1085 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 34.1085 | 5 | no |
| GO:0008104 | protein localization | 33.3333 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 31.7829 | 4 | no |
| GO:0023056 | positive regulation of signaling | 31.7829 | 4 | yes |
| GO:0043067 | regulation of programmed cell death | 31.7829 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 31.0078 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 31.0078 | 5 | yes |
| GO:0042981 | regulation of apoptotic process | 31.0078 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 30.2326 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.2326 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 30.2326 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 30.2326 | 6 | yes |
| GO:0060341 | regulation of cellular localization | 29.4574 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 28.6822 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 28.6822 | 5 | no |
| GO:0031399 | regulation of protein modification process | 28.6822 | 6 | no |
| GO:0036211 | protein modification process | 27.9070 | 4 | no |
| GO:0043412 | macromolecule modification | 27.9070 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 27.9070 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 27.9070 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 27.9070 | 6 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 27.1318 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 27.1318 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 26.3566 | 5 | no |
| GO:0032880 | regulation of protein localization | 26.3566 | 5 | no |
| GO:0030030 | cell projection organization | 25.5814 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 24.8062 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 24.8062 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 24.8062 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 24.0310 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 24.0310 | 4 | no |
| GO:0071702 | organic substance transport | 23.2558 | 4 | yes |
| GO:0010648 | negative regulation of cell communication | 23.2558 | 5 | no |
| GO:0023057 | negative regulation of signaling | 23.2558 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 23.2558 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 22.4806 | 5 | no |
| GO:0009894 | regulation of catabolic process | 22.4806 | 4 | no |
| GO:0071310 | cellular response to organic substance | 21.7054 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 21.7054 | 6 | no |
| GO:2000145 | regulation of cell motility | 21.7054 | 4 | no |
| GO:0032101 | regulation of response to external stimulus | 20.9302 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 20.9302 | 4 | no |
| GO:0030334 | regulation of cell migration | 20.9302 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 20.9302 | 7 | no |
| GO:0042325 | regulation of phosphorylation | 20.9302 | 7 | no |
| GO:0030155 | regulation of cell adhesion | 20.9302 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 20.1550 | 5 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 20.1550 | 7 | no |
| GO:0045595 | regulation of cell differentiation | 20.1550 | 4 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 20.1550 | 6 | no |
| GO:0009890 | negative regulation of biosynthetic process | 20.1550 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 20.1550 | 7 | no |
| GO:0034330 | cell junction organization | 20.1550 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 20.1550 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 19.3798 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 19.3798 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 18.6047 | 4 | yes |
| GO:0006915 | apoptotic process | 18.6047 | 4 | yes |
| GO:0010628 | positive regulation of gene expression | 18.6047 | 7 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 18.6047 | 4 | yes |
| GO:0051336 | regulation of hydrolase activity | 18.6047 | 4 | yes |
| GO:0051726 | regulation of cell cycle | 17.0543 | 4 | yes |
| GO:0031175 | neuron projection development | 14.7287 | 6 | yes |
| GO:0043068 | positive regulation of programmed cell death | 14.7287 | 5 | yes |
| GO:0051345 | positive regulation of hydrolase activity | 13.9535 | 5 | yes |
| GO:0043065 | positive regulation of apoptotic process | 13.9535 | 6 | yes |
| GO:0015031 | protein transport | 13.1783 | 4 | yes |
| GO:0098657 | import into cell | 12.4031 | 4 | yes |
| GO:0001817 | regulation of cytokine production | 10.8527 | 4 | yes |
| GO:0006886 | intracellular protein transport | 10.8527 | 4 | yes |
| GO:0033365 | protein localization to organelle | 10.8527 | 5 | yes |
| GO:0072657 | protein localization to membrane | 10.0775 | 4 | yes |
| GO:0002009 | morphogenesis of an epithelium | 10.0775 | 4 | yes |
| GO:0050865 | regulation of cell activation | 10.0775 | 4 | yes |
| GO:0022407 | regulation of cell-cell adhesion | 9.3023 | 5 | yes |
| GO:0030100 | regulation of endocytosis | 9.3023 | 5 | yes |
| GO:0008285 | negative regulation of cell population proliferation | 8.5271 | 5 | yes |
| GO:0043087 | regulation of GTPase activity | 8.5271 | 5 | yes |
| GO:0002694 | regulation of leukocyte activation | 7.7519 | 4 | yes |
| GO:0007346 | regulation of mitotic cell cycle | 7.7519 | 5 | yes |
| GO:0043547 | positive regulation of GTPase activity | 7.7519 | 6 | yes |
| GO:0072594 | establishment of protein localization to organelle | 6.9767 | 4 | yes |
| GO:0072659 | protein localization to plasma membrane | 6.9767 | 5 | yes |
| GO:1990778 | protein localization to cell periphery | 6.9767 | 5 | yes |
| GO:0030855 | epithelial cell differentiation | 6.9767 | 4 | yes |
| GO:0051249 | regulation of lymphocyte activation | 6.9767 | 5 | yes |
| GO:0060562 | epithelial tube morphogenesis | 6.2016 | 4 | yes |
| GO:0070663 | regulation of leukocyte proliferation | 6.2016 | 5 | yes |
| GO:0007162 | negative regulation of cell adhesion | 6.2016 | 5 | yes |
| GO:0050863 | regulation of T cell activation | 6.2016 | 6 | yes |
| GO:1902414 | protein localization to cell junction | 5.4264 | 5 | yes |
| GO:0002683 | negative regulation of immune system process | 5.4264 | 4 | yes |
| GO:0090150 | establishment of protein localization to membrane | 4.6512 | 4 | yes |
| GO:0150105 | protein localization to cell-cell junction | 4.6512 | 6 | yes |
| GO:1903037 | regulation of leukocyte cell-cell adhesion | 4.6512 | 6 | yes |
| GO:0001819 | positive regulation of cytokine production | 4.6512 | 5 | yes |
| GO:0032944 | regulation of mononuclear cell proliferation | 4.6512 | 6 | yes |
| GO:0045786 | negative regulation of cell cycle | 4.6512 | 5 | yes |
| GO:0048259 | regulation of receptor-mediated endocytosis | 4.6512 | 6 | yes |
| GO:0050670 | regulation of lymphocyte proliferation | 4.6512 | 6 | yes |
| GO:0090630 | activation of GTPase activity | 3.8760 | 7 | yes |
| GO:0002090 | regulation of receptor internalization | 3.8760 | 7 | yes |
| GO:0035088 | establishment or maintenance of apical/basal cell polarity | 3.8760 | 4 | yes |
| GO:0060606 | tube closure | 3.1008 | 4 | yes |
| GO:0061162 | establishment of monopolar cell polarity | 3.1008 | 4 | yes |
| GO:0061951 | establishment of protein localization to plasma membrane | 3.1008 | 5 | yes |
| GO:0001843 | neural tube closure | 3.1008 | 5 | yes |
| GO:0001919 | regulation of receptor recycling | 3.1008 | 4 | yes |
| GO:0022408 | negative regulation of cell-cell adhesion | 3.1008 | 6 | yes |
| GO:0030859 | polarized epithelial cell differentiation | 3.1008 | 5 | yes |
| GO:0032456 | endocytic recycling | 3.1008 | 4 | yes |
| GO:0035089 | establishment of apical/basal cell polarity | 3.1008 | 5 | yes |
| GO:0042060 | wound healing | 3.1008 | 4 | yes |
| GO:0042129 | regulation of T cell proliferation | 3.1008 | 7 | yes |
| GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity | 3.1008 | 5 | yes |
| GO:0045930 | negative regulation of mitotic cell cycle | 3.1008 | 6 | yes |
| GO:0050866 | negative regulation of cell activation | 3.1008 | 5 | yes |
| GO:0062237 | protein localization to postsynapse | 2.3256 | 7 | yes |
| GO:0070664 | negative regulation of leukocyte proliferation | 2.3256 | 6 | yes |
| GO:0071896 | protein localization to adherens junction | 2.3256 | 7 | yes |
| GO:0098877 | neurotransmitter receptor transport to plasma membrane | 2.3256 | 4 | yes |
| GO:0098887 | neurotransmitter receptor transport, endosome to postsynaptic membrane | 2.3256 | 5 | yes |
| GO:0098969 | neurotransmitter receptor transport to postsynaptic membrane | 2.3256 | 4 | yes |
| GO:0099638 | endosome to plasma membrane protein transport | 2.3256 | 5 | yes |
| GO:0099639 | neurotransmitter receptor transport, endosome to plasma membrane | 2.3256 | 5 | yes |
| GO:0140238 | presynaptic endocytosis | 2.3256 | 4 | yes |
| GO:1903539 | protein localization to postsynaptic membrane | 2.3256 | 5 | yes |
| GO:1903540 | establishment of protein localization to postsynaptic membrane | 2.3256 | 5 | yes |
| GO:0001921 | positive regulation of receptor recycling | 2.3256 | 5 | yes |
| GO:0002695 | negative regulation of leukocyte activation | 2.3256 | 5 | yes |
| GO:0032649 | regulation of type II interferon production | 2.3256 | 5 | yes |
| GO:0032729 | positive regulation of type II interferon production | 2.3256 | 6 | yes |
| GO:0032945 | negative regulation of mononuclear cell proliferation | 2.3256 | 7 | yes |
| GO:0035418 | protein localization to synapse | 2.3256 | 6 | yes |
| GO:0036010 | protein localization to endosome | 2.3256 | 6 | yes |
| GO:0043113 | receptor clustering | 2.3256 | 5 | yes |
| GO:0048488 | synaptic vesicle endocytosis | 2.3256 | 5 | yes |
| GO:0050672 | negative regulation of lymphocyte proliferation | 2.3256 | 7 | yes |
| GO:0051250 | negative regulation of lymphocyte activation | 2.3256 | 6 | yes |
| GO:0060088 | auditory receptor cell stereocilium organization | 1.5504 | 8 | yes |
| GO:0060122 | inner ear receptor cell stereocilium organization | 1.5504 | 7 | yes |
| GO:0060561 | apoptotic process involved in morphogenesis | 1.5504 | 6 | yes |
| GO:0060603 | mammary gland duct morphogenesis | 1.5504 | 5 | yes |
| GO:1902742 | apoptotic process involved in development | 1.5504 | 5 | yes |
| GO:1902946 | protein localization to early endosome | 1.5504 | 7 | yes |
| GO:1903038 | negative regulation of leukocyte cell-cell adhesion | 1.5504 | 7 | yes |
| GO:0001767 | establishment of lymphocyte polarity | 1.5504 | 4 | yes |
| GO:0001768 | establishment of T cell polarity | 1.5504 | 5 | yes |
| GO:0008347 | glial cell migration | 1.5504 | 4 | yes |
| GO:0021747 | cochlear nucleus development | 1.5504 | 4 | yes |
| GO:0042130 | negative regulation of T cell proliferation | 1.5504 | 8 | yes |
| GO:0043615 | astrocyte cell migration | 1.5504 | 5 | yes |
| GO:0046006 | regulation of activated T cell proliferation | 1.5504 | 8 | yes |
| GO:0046007 | negative regulation of activated T cell proliferation | 1.5504 | 9 | yes |
| GO:0050868 | negative regulation of T cell activation | 1.5504 | 7 | yes |
| GO:0050918 | positive chemotaxis | 1.5504 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MUSK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ARHG7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PKP4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ADA1D_HUMAN | [view interactions] | Low throughput | no | no |
| MK12_HUMAN | [view interactions] | Low throughput | no | no |
| GCYA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| S6A12_HUMAN | [view interactions] | Low throughput | no | no |
| TRIP6_HUMAN | [view interactions] | Low throughput | no | yes |
| CRCM_HUMAN | [view interactions] | Low throughput | no | no |
| TSHR_HUMAN | [view interactions] | Low throughput | no | no |
| ZO2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GIT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CRTAM_HUMAN | [view interactions] | Low throughput | no | no |
| PHLP1_HUMAN | [view interactions] | Low throughput | no | yes |
| OTUL_HUMAN | [view interactions] | Low throughput | no | yes |
| CTNA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PHLP2_HUMAN | [view interactions] | Low throughput | no | yes |
| KPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HGFL_HUMAN | [view interactions] | Low throughput | no | no |
| MARK4_HUMAN | [view interactions] | Low throughput | no | yes |
| KS6A2_HUMAN | [view interactions] | Low throughput | no | yes |
| ARHGQ_HUMAN | [view interactions] | Low throughput | no | yes |
| APC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| UBE3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK03_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KS6A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| WWTR1_HUMAN | [view interactions] | Low throughput | no | yes |
| LATS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SCRIB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MARK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CADH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MK01_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TANC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VANG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PPR3A_HUMAN | [view interactions] | High throughput | no | no |
| IL1R2_HUMAN | [view interactions] | High throughput | no | no |
| LRC27_HUMAN | [view interactions] | High throughput | no | yes |
| ZN263_HUMAN | [view interactions] | High throughput | no | yes |
| LRIG1_HUMAN | [view interactions] | High throughput | no | yes |
| P4HA3_HUMAN | [view interactions] | High throughput | no | no |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| RN146_HUMAN | [view interactions] | High throughput | no | yes |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| R144A_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| ARHGF_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| BRD1_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| CIC_HUMAN | [view interactions] | High throughput | no | yes |
| ZN317_HUMAN | [view interactions] | High throughput | no | yes |
| SETD2_HUMAN | [view interactions] | High throughput | no | yes |
| ZN777_HUMAN | [view interactions] | High throughput | no | yes |
| GIT2_HUMAN | [view interactions] | High throughput | no | yes |
| SLTM_HUMAN | [view interactions] | High throughput | no | yes |
| RNPS1_HUMAN | [view interactions] | High throughput | no | yes |
| DCNL2_HUMAN | [view interactions] | High throughput | no | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZN697_HUMAN | [view interactions] | High throughput | no | no |
| ZN316_HUMAN | [view interactions] | High throughput | no | no |
| ZN768_HUMAN | [view interactions] | High throughput | no | yes |
| PPHLN_HUMAN | [view interactions] | High throughput | no | yes |
| ZKSC8_HUMAN | [view interactions] | High throughput | no | yes |
| KCNA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRC1_HUMAN | [view interactions] | High throughput | no | yes |
| CA226_HUMAN | [view interactions] | High throughput | no | yes |
| LRC40_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEK1_HUMAN | [view interactions] | High throughput | no | yes |
| KIF1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| I2BP2_HUMAN | [view interactions] | High throughput | no | yes |
| ZN628_HUMAN | [view interactions] | High throughput | no | no |
| AAKB2_HUMAN | [view interactions] | High throughput | no | yes |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| HME1_HUMAN | [view interactions] | High throughput | no | no |
| ZN638_HUMAN | [view interactions] | High throughput | no | yes |
| C170B_HUMAN | [view interactions] | High throughput | no | yes |
| ZN483_HUMAN | [view interactions] | High throughput | no | no |
| PATZ1_HUMAN | [view interactions] | High throughput | no | yes |
| I2BPL_HUMAN | [view interactions] | High throughput | no | yes |
| SGT1_HUMAN | [view interactions] | High throughput | no | no |
| ZN592_HUMAN | [view interactions] | High throughput | no | yes |
| ZN449_HUMAN | [view interactions] | High throughput | no | no |
| ZN219_HUMAN | [view interactions] | High throughput | no | yes |
| ZNF7_HUMAN | [view interactions] | High throughput | no | yes |
| ARHG8_HUMAN | [view interactions] | High throughput | no | yes |
| CAPON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCNA5_HUMAN | [view interactions] | High throughput | no | no |
| I2BP1_HUMAN | [view interactions] | High throughput | no | yes |
| VWCE_HUMAN | [view interactions] | High throughput | no | no |
| SHKB1_HUMAN | [view interactions] | High throughput | no | yes |
| DNM1L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FP100_HUMAN | [view interactions] | High throughput | no | yes |
| CPVL_HUMAN | [view interactions] | High throughput | no | no |
| NXPE2_HUMAN | [view interactions] | High throughput | no | no |
| PI42A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTND2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KLH13_HUMAN | [view interactions] | High throughput | no | no |
| ZSWM1_HUMAN | [view interactions] | High throughput | no | yes |
| SF3B3_HUMAN | [view interactions] | High throughput | no | yes |
| ATD2B_HUMAN | [view interactions] | High throughput | no | yes |
| PI42B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRAF7_HUMAN | [view interactions] | High throughput | no | yes |
| KLHL9_HUMAN | [view interactions] | High throughput | no | no |
| SO1C1_HUMAN | [view interactions] | High throughput | no | no |
| AAKG2_HUMAN | [view interactions] | High throughput | no | yes |
| RBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAKG1_HUMAN | [view interactions] | High throughput | no | no |
| PAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ADA22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRSM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCNB2_HUMAN | [view interactions] | High throughput | no | no |
| LMO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MRP4_HUMAN | [view interactions] | High throughput | no | no |
| PI42C_HUMAN | [view interactions] | High throughput | no | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| SIR6_HUMAN | [view interactions] | High throughput | no | yes |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| KCNA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DLK2_HUMAN | [view interactions] | High throughput | no | no |
| PIGR_HUMAN | [view interactions] | High throughput | no | no |
| ANR50_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| S15A5_HUMAN | [view interactions] | High throughput | no | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EREP3_HUMAN | [view interactions] | High throughput | no | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPR1B_HUMAN | [view interactions] | High throughput | no | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| TMIG1_HUMAN | [view interactions] | High throughput | no | no |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| STAR8_HUMAN | [view interactions] | High throughput | no | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN563_HUMAN | [view interactions] | High throughput | no | no |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| S4A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NR2E1_HUMAN | [view interactions] | High throughput | no | yes |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| LNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| KCJ12_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| KCNJ4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| ACTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| ACTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| ACTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| EXOSX_HUMAN | [view interactions] | High throughput | no | yes |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TS101_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| CENPC_HUMAN | [view interactions] | High throughput | no | no |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| RUFY1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SLX4_HUMAN | [view interactions] | High throughput | no | yes |
| GCSP_HUMAN | [view interactions] | High throughput | no | yes |
| DMWD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MIDN_HUMAN | [view interactions] | High throughput | no | no |
| PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| DAA11_HUMAN | [view interactions] | High throughput | no | no |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| NU107_HUMAN | [view interactions] | High throughput | no | no |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPTC2_HUMAN | [view interactions] | High throughput | no | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TGS1_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KS6A3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KI67_HUMAN | [view interactions] | High throughput | no | no |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| PAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARHGG_HUMAN | [view interactions] | High throughput | no | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| ZN446_HUMAN | [view interactions] | High throughput | no | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| E41LA_HUMAN | [view interactions] | High throughput | no | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MB212_HUMAN | [view interactions] | High throughput | no | no |
| AFAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN213_HUMAN | [view interactions] | High throughput | no | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| SNTA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PARD3_HUMAN | [view interactions] | High throughput | no | yes |
| RASA1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAC14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CHERP_HUMAN | [view interactions] | High throughput | no | no |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| APOB_HUMAN | [view interactions] | High throughput | no | no |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM38_HUMAN | [view interactions] | High throughput | no | yes |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| CELF1_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| RALB_HUMAN | [view interactions] | High throughput | no | no |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| TPP2_HUMAN | [view interactions] | High throughput | no | yes |
| RNF43_HUMAN | [view interactions] | High throughput | no | yes |
| SYIM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH2B1_HUMAN | [view interactions] | High throughput | no | yes |
| AR13B_HUMAN | [view interactions] | High throughput | no | yes |
| DESP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| P4HA1_HUMAN | [view interactions] | High throughput | no | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G6PI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSK3A_HUMAN | [view interactions] | High throughput | no | yes |
| GELS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRIPB_HUMAN | [view interactions] | High throughput | no | yes |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| CLK3_HUMAN | [view interactions] | High throughput | no | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| C5AR2_HUMAN | [view interactions] | High throughput | no | yes |
| M3K3_HUMAN | [view interactions] | High throughput | no | no |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCNL1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| FOXB1_HUMAN | [view interactions] | High throughput | no | no |
| FOXE1_HUMAN | [view interactions] | High throughput | no | no |
| FOXG1_HUMAN | [view interactions] | High throughput | no | no |
| FOXH1_HUMAN | [view interactions] | High throughput | no | no |
| FOXL1_HUMAN | [view interactions] | High throughput | no | no |
| FOXK1_HUMAN | [view interactions] | High throughput | no | yes |
| SNTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DTNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UTRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARHG6_HUMAN | [view interactions] | High throughput | no | no |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| FBF1_HUMAN | [view interactions] | High throughput | no | no |
| CEP19_HUMAN | [view interactions] | High throughput | no | no |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MED4_HUMAN | [view interactions] | High throughput | no | yes |
| KCNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYRK2_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EPHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STYK1_HUMAN | [view interactions] | High throughput | no | yes |
| KCNK3_HUMAN | [view interactions] | High throughput | no | no |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPNE8_HUMAN | [view interactions] | High throughput | no | yes |
| AT2B2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAKD5_HUMAN | [view interactions] | High throughput | no | yes |
| F163B_HUMAN | [view interactions] | High throughput | no | yes |
| MELT_HUMAN | [view interactions] | High throughput | no | yes |
| AT2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WTIP_HUMAN | [view interactions] | High throughput | no | no |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| CRFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLTR2_HUMAN | [view interactions] | High throughput | no | no |
| FRPD4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBCD8_HUMAN | [view interactions] | High throughput | no | yes |
| PRDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 5HT2C_HUMAN | [view interactions] | High throughput | no | no |
| MOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FRPD1_HUMAN | [view interactions] | High throughput | no | yes |
| OR5F1_HUMAN | [view interactions] | High throughput | no | no |
| CSN1_HUMAN | [view interactions] | High throughput | no | no |
| ASND1_HUMAN | [view interactions] | High throughput | no | yes |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PD2R_HUMAN | [view interactions] | High throughput | no | no |
| XKR4_HUMAN | [view interactions] | High throughput | no | no |
| HTR5B_HUMAN | [view interactions] | High throughput | no | yes |
| UT1_HUMAN | [view interactions] | High throughput | no | no |
| S4A7_HUMAN | [view interactions] | High throughput | no | no |
| MOT4_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| SHOC2_HUMAN | [view interactions] | High throughput | no | yes |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| LGR4_HUMAN | [view interactions] | High throughput | no | yes |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| CNPY3_HUMAN | [view interactions] | High throughput | no | yes |
| CL18A_HUMAN | [view interactions] | High throughput | no | no |
| RBM23_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT44_HUMAN | [view interactions] | High throughput | no | yes |