ARHGF_HUMAN
Evidence for PS localization
Functions
Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ARHGF_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 46.6667 | 4 | no |
| GO:0019900 | kinase binding | 40.0000 | 4 | no |
| GO:0019901 | protein kinase binding | 40.0000 | 5 | no |
| GO:0017076 | purine nucleotide binding | 33.3333 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 33.3333 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 33.3333 | 4 | no |
| GO:0003779 | actin binding | 26.6667 | 4 | no |
| GO:0045296 | cadherin binding | 26.6667 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ARHGF_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 60.0000 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 60.0000 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 60.0000 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 53.3333 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 53.3333 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 53.3333 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 53.3333 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 53.3333 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 46.6667 | 5 | yes |
| GO:0031323 | regulation of cellular metabolic process | 46.6667 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 46.6667 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 46.6667 | 5 | no |
| GO:0010468 | regulation of gene expression | 46.6667 | 5 | no |
| GO:0009966 | regulation of signal transduction | 46.6667 | 4 | yes |
| GO:0010646 | regulation of cell communication | 46.6667 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 46.6667 | 5 | yes |
| GO:0051336 | regulation of hydrolase activity | 40.0000 | 4 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 40.0000 | 4 | no |
| GO:0022604 | regulation of cell morphogenesis | 40.0000 | 5 | no |
| GO:0043412 | macromolecule modification | 40.0000 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 40.0000 | 6 | no |
| GO:0071310 | cellular response to organic substance | 40.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 40.0000 | 4 | no |
| GO:0051049 | regulation of transport | 40.0000 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 40.0000 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 40.0000 | 4 | yes |
| GO:0051345 | positive regulation of hydrolase activity | 33.3333 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 33.3333 | 4 | no |
| GO:0030030 | cell projection organization | 33.3333 | 4 | no |
| GO:0030155 | regulation of cell adhesion | 33.3333 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 33.3333 | 5 | no |
| GO:0036211 | protein modification process | 33.3333 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 33.3333 | 6 | no |
| GO:2000145 | regulation of cell motility | 33.3333 | 4 | no |
| GO:0032880 | regulation of protein localization | 33.3333 | 5 | no |
| GO:0051726 | regulation of cell cycle | 33.3333 | 4 | no |
| GO:0060341 | regulation of cellular localization | 33.3333 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 33.3333 | 6 | no |
| GO:0035088 | establishment or maintenance of apical/basal cell polarity | 33.3333 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 33.3333 | 4 | no |
| GO:0043087 | regulation of GTPase activity | 33.3333 | 5 | yes |
| GO:0051129 | negative regulation of cellular component organization | 33.3333 | 5 | yes |
| GO:0051130 | positive regulation of cellular component organization | 33.3333 | 5 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 26.6667 | 6 | yes |
| GO:0110053 | regulation of actin filament organization | 26.6667 | 6 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 26.6667 | 5 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 26.6667 | 4 | no |
| GO:0007162 | negative regulation of cell adhesion | 26.6667 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 26.6667 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 26.6667 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 26.6667 | 5 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 26.6667 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 26.6667 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 26.6667 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 26.6667 | 6 | no |
| GO:0023057 | negative regulation of signaling | 26.6667 | 4 | no |
| GO:0030334 | regulation of cell migration | 26.6667 | 5 | no |
| GO:0034248 | regulation of cellular amide metabolic process | 26.6667 | 5 | no |
| GO:0034330 | cell junction organization | 26.6667 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 26.6667 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 26.6667 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 26.6667 | 8 | no |
| GO:0043408 | regulation of MAPK cascade | 26.6667 | 6 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 26.6667 | 7 | no |
| GO:0048584 | positive regulation of response to stimulus | 26.6667 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 26.6667 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 26.6667 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 26.6667 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 26.6667 | 4 | no |
| GO:0051338 | regulation of transferase activity | 26.6667 | 4 | no |
| GO:0051347 | positive regulation of transferase activity | 26.6667 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 26.6667 | 5 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 26.6667 | 4 | no |
| GO:1902532 | negative regulation of intracellular signal transduction | 26.6667 | 6 | no |
| GO:0007346 | regulation of mitotic cell cycle | 26.6667 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 26.6667 | 4 | no |
| GO:0009894 | regulation of catabolic process | 26.6667 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 26.6667 | 5 | no |
| GO:0010564 | regulation of cell cycle process | 26.6667 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.6667 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 26.6667 | 5 | no |
| GO:0042176 | regulation of protein catabolic process | 26.6667 | 5 | no |
| GO:0006996 | organelle organization | 26.6667 | 4 | no |
| GO:0008104 | protein localization | 26.6667 | 4 | no |
| GO:0008360 | regulation of cell shape | 26.6667 | 6 | no |
| GO:0032386 | regulation of intracellular transport | 26.6667 | 5 | no |
| GO:0032388 | positive regulation of intracellular transport | 26.6667 | 5 | no |
| GO:0032535 | regulation of cellular component size | 26.6667 | 4 | no |
| GO:0051050 | positive regulation of transport | 26.6667 | 4 | no |
| GO:1902115 | regulation of organelle assembly | 26.6667 | 5 | no |
| GO:1903829 | positive regulation of protein localization | 26.6667 | 5 | no |
| GO:0043254 | regulation of protein-containing complex assembly | 26.6667 | 5 | no |
| GO:0030855 | epithelial cell differentiation | 26.6667 | 4 | no |
| GO:0030859 | polarized epithelial cell differentiation | 26.6667 | 5 | no |
| GO:0035089 | establishment of apical/basal cell polarity | 26.6667 | 5 | no |
| GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity | 26.6667 | 5 | no |
| GO:0061162 | establishment of monopolar cell polarity | 26.6667 | 4 | no |
| GO:0010638 | positive regulation of organelle organization | 26.6667 | 6 | yes |
| GO:0032231 | regulation of actin filament bundle assembly | 26.6667 | 5 | yes |
| GO:0032956 | regulation of actin cytoskeleton organization | 26.6667 | 5 | yes |
| GO:0032970 | regulation of actin filament-based process | 26.6667 | 4 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 26.6667 | 5 | yes |
| GO:0050807 | regulation of synapse organization | 26.6667 | 5 | yes |
| GO:0051492 | regulation of stress fiber assembly | 20.0000 | 6 | yes |
| GO:0051495 | positive regulation of cytoskeleton organization | 20.0000 | 7 | yes |
| GO:0051496 | positive regulation of stress fiber assembly | 20.0000 | 7 | yes |
| GO:0110020 | regulation of actomyosin structure organization | 20.0000 | 6 | yes |
| GO:1902905 | positive regulation of supramolecular fiber organization | 20.0000 | 6 | yes |
| GO:0032233 | positive regulation of actin filament bundle assembly | 20.0000 | 6 | yes |
| GO:0043547 | positive regulation of GTPase activity | 20.0000 | 6 | yes |
| GO:0051093 | negative regulation of developmental process | 20.0000 | 4 | yes |
| GO:0090630 | activation of GTPase activity | 13.3333 | 7 | yes |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 13.3333 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| EPHA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBE3A_HUMAN | [view interactions] | Low throughput | no | yes |
| H15_HUMAN | [view interactions] | High throughput | no | no |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| CEP55_HUMAN | [view interactions] | High throughput | no | yes |
| GORS2_HUMAN | [view interactions] | High throughput | no | yes |
| PHOCN_HUMAN | [view interactions] | High throughput | no | yes |
| CK049_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| ERR3_HUMAN | [view interactions] | High throughput | no | yes |
| LASP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH3R1_HUMAN | [view interactions] | High throughput | no | yes |
| KGP1_HUMAN | [view interactions] | High throughput | no | yes |
| CALU_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RT23_HUMAN | [view interactions] | High throughput | no | yes |
| MOES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PP1RA_HUMAN | [view interactions] | High throughput | no | yes |
| PTMA_HUMAN | [view interactions] | High throughput | no | yes |
| RADI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SGT1_HUMAN | [view interactions] | High throughput | no | no |
| ATP5H_HUMAN | [view interactions] | High throughput | no | yes |
| CCNT1_HUMAN | [view interactions] | High throughput | no | yes |
| KCRU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDB1_HUMAN | [view interactions] | High throughput | no | yes |
| DDX42_HUMAN | [view interactions] | High throughput | no | yes |
| FA76B_HUMAN | [view interactions] | High throughput | no | no |
| SYFA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX3_HUMAN | [view interactions] | High throughput | no | yes |
| PSPC1_HUMAN | [view interactions] | High throughput | no | yes |
| P5CR2_HUMAN | [view interactions] | High throughput | no | yes |
| RCN1_HUMAN | [view interactions] | High throughput | no | yes |
| RS27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCRIB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SF3B5_HUMAN | [view interactions] | High throughput | no | yes |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP2L_HUMAN | [view interactions] | High throughput | no | yes |
| TYY1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN326_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| EFNA1_HUMAN | [view interactions] | Computational | no | no |