Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ARHGF_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ARHGF_HUMAN
GO:0003723 RNA binding 41.1765 4 no
GO:0019900 kinase binding 41.1765 4 no
GO:0043168 anion binding 35.2941 4 no
GO:0043169 cation binding 35.2941 4 no
GO:0046872 metal ion binding 35.2941 5 no
GO:0019901 protein kinase binding 35.2941 5 no
GO:0000166 nucleotide binding 29.4118 4 no
GO:0017076 purine nucleotide binding 29.4118 5 no
GO:0032555 purine ribonucleotide binding 29.4118 4 no
GO:0035639 purine ribonucleoside triphosphate binding 29.4118 4 no
GO:0003779 actin binding 23.5294 4 no
GO:0045296 cadherin binding 23.5294 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in ARHGF_HUMAN
GO:0048522 positive regulation of cellular process 64.7059 4 yes
GO:0051128 regulation of cellular component organization 58.8235 4 yes
GO:0060255 regulation of macromolecule metabolic process 58.8235 4 no
GO:0010604 positive regulation of macromolecule metabolic process 52.9412 5 no
GO:0048523 negative regulation of cellular process 52.9412 4 yes
GO:0009889 regulation of biosynthetic process 52.9412 4 no
GO:0010468 regulation of gene expression 52.9412 6 no
GO:0010556 regulation of macromolecule biosynthetic process 52.9412 5 no
GO:0031323 regulation of cellular metabolic process 52.9412 4 no
GO:0031326 regulation of cellular biosynthetic process 52.9412 5 no
GO:0080090 regulation of primary metabolic process 52.9412 4 no
GO:0009893 positive regulation of metabolic process 52.9412 4 no
GO:0031325 positive regulation of cellular metabolic process 47.0588 5 no
GO:0009966 regulation of signal transduction 47.0588 4 yes
GO:0010646 regulation of cell communication 47.0588 4 yes
GO:1902531 regulation of intracellular signal transduction 47.0588 5 yes
GO:0051246 regulation of protein metabolic process 47.0588 5 no
GO:0051247 positive regulation of protein metabolic process 41.1765 6 no
GO:0033043 regulation of organelle organization 41.1765 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 35.2941 6 no
GO:0031328 positive regulation of cellular biosynthetic process 35.2941 6 no
GO:2000145 regulation of cell motility 35.2941 4 no
GO:0031344 regulation of cell projection organization 35.2941 5 no
GO:0071310 cellular response to organic substance 35.2941 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 35.2941 6 no
GO:0044087 regulation of cellular component biogenesis 35.2941 4 yes
GO:0022607 cellular component assembly 35.2941 4 no
GO:0043412 macromolecule modification 35.2941 4 no
GO:0009891 positive regulation of biosynthetic process 35.2941 5 no
GO:0009968 negative regulation of signal transduction 29.4118 5 no
GO:0010648 negative regulation of cell communication 29.4118 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 29.4118 5 no
GO:0023056 positive regulation of signaling 29.4118 4 no
GO:0023057 negative regulation of signaling 29.4118 4 no
GO:0032880 regulation of protein localization 29.4118 5 no
GO:0048585 negative regulation of response to stimulus 29.4118 4 no
GO:0051336 regulation of hydrolase activity 29.4118 4 no
GO:0051726 regulation of cell cycle 29.4118 4 no
GO:0060341 regulation of cellular localization 29.4118 4 no
GO:0022603 regulation of anatomical structure morphogenesis 29.4118 4 no
GO:0030155 regulation of cell adhesion 29.4118 4 no
GO:0030334 regulation of cell migration 29.4118 5 no
GO:0051049 regulation of transport 29.4118 4 no
GO:0060627 regulation of vesicle-mediated transport 29.4118 4 no
GO:0035088 establishment or maintenance of apical/basal cell polarity 29.4118 4 no
GO:0050807 regulation of synapse organization 29.4118 5 yes
GO:0051129 negative regulation of cellular component organization 29.4118 5 yes
GO:0051130 positive regulation of cellular component organization 29.4118 5 yes
GO:0036211 protein modification process 29.4118 4 no
GO:0042127 regulation of cell population proliferation 29.4118 4 no
GO:0009894 regulation of catabolic process 29.4118 4 no
GO:0009967 positive regulation of signal transduction 23.5294 5 no
GO:0010564 regulation of cell cycle process 23.5294 5 no
GO:0010647 positive regulation of cell communication 23.5294 5 no
GO:0031399 regulation of protein modification process 23.5294 6 no
GO:0031401 positive regulation of protein modification process 23.5294 7 no
GO:0034330 cell junction organization 23.5294 4 no
GO:0042176 regulation of protein catabolic process 23.5294 5 no
GO:0043085 positive regulation of catalytic activity 23.5294 4 no
GO:0043087 regulation of GTPase activity 23.5294 5 no
GO:0043408 regulation of MAPK cascade 23.5294 6 no
GO:0048584 positive regulation of response to stimulus 23.5294 4 no
GO:0051252 regulation of RNA metabolic process 23.5294 5 no
GO:0051345 positive regulation of hydrolase activity 23.5294 5 no
GO:1902532 negative regulation of intracellular signal transduction 23.5294 6 no
GO:2001141 regulation of RNA biosynthetic process 23.5294 6 no
GO:0007162 negative regulation of cell adhesion 23.5294 5 no
GO:0008104 protein localization 23.5294 4 no
GO:0010628 positive regulation of gene expression 23.5294 7 no
GO:0022604 regulation of cell morphogenesis 23.5294 5 no
GO:0030335 positive regulation of cell migration 23.5294 6 no
GO:0032386 regulation of intracellular transport 23.5294 5 no
GO:0032388 positive regulation of intracellular transport 23.5294 5 no
GO:0032535 regulation of cellular component size 23.5294 4 no
GO:0040017 positive regulation of locomotion 23.5294 4 no
GO:0043254 regulation of protein-containing complex assembly 23.5294 5 no
GO:0051050 positive regulation of transport 23.5294 4 no
GO:1902115 regulation of organelle assembly 23.5294 5 no
GO:1903829 positive regulation of protein localization 23.5294 5 no
GO:2000147 positive regulation of cell motility 23.5294 5 no
GO:0030030 cell projection organization 23.5294 4 no
GO:0051240 positive regulation of multicellular organismal process 23.5294 4 no
GO:0051241 negative regulation of multicellular organismal process 23.5294 4 no
GO:0120036 plasma membrane bounded cell projection organization 23.5294 5 no
GO:1901701 cellular response to oxygen-containing compound 23.5294 4 no
GO:0030855 epithelial cell differentiation 23.5294 4 no
GO:0030859 polarized epithelial cell differentiation 23.5294 5 no
GO:0035089 establishment of apical/basal cell polarity 23.5294 5 no
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 23.5294 5 no
GO:0061162 establishment of monopolar cell polarity 23.5294 4 no
GO:0098657 import into cell 23.5294 4 no
GO:0010638 positive regulation of organelle organization 23.5294 6 yes
GO:0032231 regulation of actin filament bundle assembly 23.5294 5 yes
GO:0032956 regulation of actin cytoskeleton organization 23.5294 5 yes
GO:0032970 regulation of actin filament-based process 23.5294 4 yes
GO:0044089 positive regulation of cellular component biogenesis 23.5294 5 yes
GO:0051493 regulation of cytoskeleton organization 23.5294 6 yes
GO:0099175 regulation of postsynapse organization 23.5294 6 yes
GO:0110053 regulation of actin filament organization 23.5294 6 yes
GO:1902903 regulation of supramolecular fiber organization 23.5294 5 yes
GO:0006996 organelle organization 23.5294 4 no
GO:0006355 regulation of DNA-templated transcription 23.5294 7 no
GO:0006357 regulation of transcription by RNA polymerase II 23.5294 8 no
GO:0007346 regulation of mitotic cell cycle 23.5294 5 no
GO:0009892 negative regulation of metabolic process 23.5294 4 no
GO:0032233 positive regulation of actin filament bundle assembly 17.6471 6 yes
GO:0051093 negative regulation of developmental process 17.6471 4 yes
GO:0051492 regulation of stress fiber assembly 17.6471 6 yes
GO:0051495 positive regulation of cytoskeleton organization 17.6471 7 yes
GO:0051496 positive regulation of stress fiber assembly 17.6471 7 yes
GO:0110020 regulation of actomyosin structure organization 17.6471 6 yes
GO:1902905 positive regulation of supramolecular fiber organization 17.6471 6 yes
GO:0051056 regulation of small GTPase mediated signal transduction 11.7647 6 yes
GO:1901888 regulation of cell junction assembly 11.7647 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
EPHA4_HUMAN [view entry] [view interactions] Low throughput yes yes
UBE3A_HUMAN [view entry] [view interactions] Low throughput yes yes
ERR3_HUMAN [view interactions] High throughput no yes
SH3R1_HUMAN [view interactions] High throughput no yes
KGP1_HUMAN [view interactions] High throughput no yes
CALU_HUMAN [view interactions] High throughput no yes
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
RT23_HUMAN [view interactions] High throughput no yes
MOES_HUMAN [view entry] [view interactions] High throughput yes no
PP1RA_HUMAN [view interactions] High throughput no yes
PTMA_HUMAN [view interactions] High throughput no yes
RADI_HUMAN [view entry] [view interactions] High throughput yes yes
SGT1_HUMAN [view interactions] High throughput no no
ATP5H_HUMAN [view interactions] High throughput no yes
CCNT1_HUMAN [view interactions] High throughput no yes
KCRU_HUMAN [view entry] [view interactions] High throughput yes yes
DDB1_HUMAN [view interactions] High throughput no yes
DDX42_HUMAN [view interactions] High throughput no yes
FA76B_HUMAN [view interactions] High throughput no no
SYFA_HUMAN [view entry] [view interactions] High throughput yes yes
HCD2_HUMAN [view entry] [view interactions] High throughput yes yes
PRDX3_HUMAN [view interactions] High throughput no yes
PSPC1_HUMAN [view interactions] High throughput no yes
P5CR2_HUMAN [view interactions] High throughput no yes
RCN1_HUMAN [view interactions] High throughput no yes
RS27A_HUMAN [view entry] [view interactions] High throughput yes yes
SCRIB_HUMAN [view entry] [view interactions] High throughput yes no
SF3B5_HUMAN [view interactions] High throughput no yes
GLYM_HUMAN [view entry] [view interactions] High throughput yes yes
UBP2L_HUMAN [view interactions] High throughput no yes
TYY1_HUMAN [view interactions] High throughput no yes
ZN326_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
CDK7_HUMAN [view interactions] High throughput no yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
ESR1_HUMAN [view interactions] High throughput no no
H15_HUMAN [view interactions] High throughput no no
BICD2_HUMAN [view interactions] High throughput no yes
CEP55_HUMAN [view interactions] High throughput no yes
PIN1_HUMAN [view entry] [view interactions] High throughput yes yes
LASP1_HUMAN [view entry] [view interactions] High throughput yes yes
GORS2_HUMAN [view interactions] High throughput no yes
PHOCN_HUMAN [view entry] [view interactions] High throughput yes yes
CSTP1_HUMAN [view interactions] High throughput no yes
DNJC5_HUMAN [view interactions] High throughput no yes