PIN1_HUMAN
Evidence for PS localization
Functions
Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs (PubMed, PubMed, PubMed). By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes (PubMed, PubMed, PubMed). Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed). May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed, PubMed). Upon IL33-induced lung inflammation, catalyzes cis-trans isomerization of phosphorylated IRAK3/IRAK-M, inducing IRAK3 stabilization, nuclear translocation and expression of pro-inflammatory genes in dendritic cells (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PIN1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 33.3333 | 4 | no |
| GO:0000166 | nucleotide binding | 28.2051 | 4 | no |
| GO:0017076 | purine nucleotide binding | 26.9231 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 26.9231 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 24.3590 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 24.3590 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 24.3590 | 4 | no |
| GO:0005524 | ATP binding | 21.7949 | 5 | no |
| GO:0003723 | RNA binding | 20.5128 | 4 | no |
| GO:0019900 | kinase binding | 19.2308 | 4 | yes |
| GO:0019901 | protein kinase binding | 16.6667 | 5 | yes |
| GO:0048156 | tau protein binding | 3.8462 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PIN1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 67.9487 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 62.8205 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 61.5385 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 60.2564 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 58.9744 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 51.2821 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 51.2821 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 51.2821 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 50.0000 | 5 | yes |
| GO:0010468 | regulation of gene expression | 47.4359 | 6 | yes |
| GO:0010646 | regulation of cell communication | 47.4359 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 46.1538 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 44.8718 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 44.8718 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 44.8718 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 41.0256 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 41.0256 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 41.0256 | 5 | yes |
| GO:0051252 | regulation of RNA metabolic process | 41.0256 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 39.7436 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 39.7436 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 37.1795 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 37.1795 | 6 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 34.6154 | 5 | yes |
| GO:0006996 | organelle organization | 34.6154 | 4 | no |
| GO:0008104 | protein localization | 32.0513 | 4 | no |
| GO:0031399 | regulation of protein modification process | 30.7692 | 6 | yes |
| GO:0048584 | positive regulation of response to stimulus | 30.7692 | 4 | yes |
| GO:0022607 | cellular component assembly | 30.7692 | 4 | no |
| GO:0043067 | regulation of programmed cell death | 30.7692 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 30.7692 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 30.7692 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 30.7692 | 6 | no |
| GO:0009891 | positive regulation of biosynthetic process | 29.4872 | 5 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 29.4872 | 6 | yes |
| GO:0036211 | protein modification process | 29.4872 | 4 | yes |
| GO:0043412 | macromolecule modification | 29.4872 | 4 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 29.4872 | 6 | yes |
| GO:0042981 | regulation of apoptotic process | 29.4872 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 28.2051 | 6 | yes |
| GO:0010647 | positive regulation of cell communication | 28.2051 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 28.2051 | 4 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 28.2051 | 6 | yes |
| GO:0051130 | positive regulation of cellular component organization | 28.2051 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 28.2051 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 26.9231 | 5 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 26.9231 | 6 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 26.9231 | 5 | yes |
| GO:0043069 | negative regulation of programmed cell death | 26.9231 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 26.9231 | 4 | no |
| GO:0090304 | nucleic acid metabolic process | 26.9231 | 4 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 25.6410 | 8 | yes |
| GO:0009894 | regulation of catabolic process | 25.6410 | 4 | yes |
| GO:0010648 | negative regulation of cell communication | 25.6410 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 25.6410 | 4 | yes |
| GO:0042325 | regulation of phosphorylation | 25.6410 | 7 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 25.6410 | 5 | yes |
| GO:0048585 | negative regulation of response to stimulus | 25.6410 | 4 | yes |
| GO:0051254 | positive regulation of RNA metabolic process | 25.6410 | 6 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 25.6410 | 4 | no |
| GO:0043066 | negative regulation of apoptotic process | 25.6410 | 6 | no |
| GO:0051049 | regulation of transport | 25.6410 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 24.3590 | 7 | yes |
| GO:0009968 | negative regulation of signal transduction | 24.3590 | 5 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 24.3590 | 8 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 24.3590 | 7 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 24.3590 | 4 | no |
| GO:0071702 | organic substance transport | 24.3590 | 4 | no |
| GO:0016070 | RNA metabolic process | 24.3590 | 5 | no |
| GO:0033043 | regulation of organelle organization | 23.0769 | 5 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 23.0769 | 4 | no |
| GO:0080134 | regulation of response to stress | 23.0769 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 23.0769 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 21.7949 | 7 | yes |
| GO:0043933 | protein-containing complex organization | 21.7949 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 20.5128 | 6 | yes |
| GO:0042327 | positive regulation of phosphorylation | 20.5128 | 8 | yes |
| GO:0045937 | positive regulation of phosphate metabolic process | 20.5128 | 7 | yes |
| GO:0060341 | regulation of cellular localization | 20.5128 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 20.5128 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 20.5128 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 20.5128 | 4 | no |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 20.5128 | 5 | no |
| GO:0043549 | regulation of kinase activity | 20.5128 | 5 | no |
| GO:0051338 | regulation of transferase activity | 20.5128 | 4 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 19.2308 | 8 | yes |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | 19.2308 | 9 | yes |
| GO:0032880 | regulation of protein localization | 17.9487 | 5 | yes |
| GO:0043408 | regulation of MAPK cascade | 17.9487 | 6 | yes |
| GO:0009895 | negative regulation of catabolic process | 16.6667 | 5 | yes |
| GO:0043085 | positive regulation of catalytic activity | 16.6667 | 4 | yes |
| GO:0034330 | cell junction organization | 15.3846 | 4 | yes |
| GO:0018193 | peptidyl-amino acid modification | 14.1026 | 5 | yes |
| GO:0030111 | regulation of Wnt signaling pathway | 14.1026 | 5 | yes |
| GO:0051726 | regulation of cell cycle | 14.1026 | 4 | yes |
| GO:1902532 | negative regulation of intracellular signal transduction | 14.1026 | 6 | yes |
| GO:0010564 | regulation of cell cycle process | 11.5385 | 5 | yes |
| GO:0051336 | regulation of hydrolase activity | 11.5385 | 4 | yes |
| GO:2000145 | regulation of cell motility | 11.5385 | 4 | yes |
| GO:0042176 | regulation of protein catabolic process | 10.2564 | 5 | yes |
| GO:0050808 | synapse organization | 10.2564 | 5 | yes |
| GO:0007346 | regulation of mitotic cell cycle | 7.6923 | 5 | yes |
| GO:0030182 | neuron differentiation | 7.6923 | 4 | yes |
| GO:0042177 | negative regulation of protein catabolic process | 7.6923 | 6 | yes |
| GO:0043393 | regulation of protein binding | 7.6923 | 4 | yes |
| GO:0051099 | positive regulation of binding | 7.6923 | 4 | yes |
| GO:0032092 | positive regulation of protein binding | 6.4103 | 5 | yes |
| GO:0036293 | response to decreased oxygen levels | 6.4103 | 4 | yes |
| GO:0050821 | protein stabilization | 6.4103 | 4 | yes |
| GO:0060828 | regulation of canonical Wnt signaling pathway | 6.4103 | 6 | yes |
| GO:0070372 | regulation of ERK1 and ERK2 cascade | 6.4103 | 7 | yes |
| GO:0043409 | negative regulation of MAPK cascade | 5.1282 | 7 | yes |
| GO:0051345 | positive regulation of hydrolase activity | 5.1282 | 5 | yes |
| GO:0000413 | protein peptidyl-prolyl isomerization | 3.8462 | 7 | yes |
| GO:0018208 | peptidyl-proline modification | 3.8462 | 6 | yes |
| GO:0030177 | positive regulation of Wnt signaling pathway | 3.8462 | 6 | yes |
| GO:0034248 | regulation of amide metabolic process | 3.8462 | 4 | yes |
| GO:0035303 | regulation of dephosphorylation | 3.8462 | 7 | yes |
| GO:0035304 | regulation of protein dephosphorylation | 3.8462 | 7 | yes |
| GO:0040013 | negative regulation of locomotion | 3.8462 | 4 | yes |
| GO:0051302 | regulation of cell division | 3.8462 | 4 | yes |
| GO:0090287 | regulation of cellular response to growth factor stimulus | 3.8462 | 4 | yes |
| GO:2000146 | negative regulation of cell motility | 3.8462 | 5 | yes |
| GO:0007088 | regulation of mitotic nuclear division | 2.5641 | 6 | yes |
| GO:0032091 | negative regulation of protein binding | 2.5641 | 5 | yes |
| GO:0032465 | regulation of cytokinesis | 2.5641 | 5 | yes |
| GO:0035306 | positive regulation of dephosphorylation | 2.5641 | 8 | yes |
| GO:0035307 | positive regulation of protein dephosphorylation | 2.5641 | 8 | yes |
| GO:0051100 | negative regulation of binding | 2.5641 | 4 | yes |
| GO:0051783 | regulation of nuclear division | 2.5641 | 6 | yes |
| GO:0090092 | regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 2.5641 | 5 | yes |
| GO:0090101 | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 2.5641 | 6 | yes |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway | 2.5641 | 7 | yes |
| GO:1902003 | regulation of amyloid-beta formation | 2.5641 | 5 | yes |
| GO:1902991 | regulation of amyloid precursor protein catabolic process | 2.5641 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| FOS_HUMAN | [view interactions] | Low throughput | no | yes |
| KCND2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433S_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GLI1_HUMAN | [view interactions] | Low throughput | no | no |
| NCOA3_HUMAN | [view interactions] | Low throughput | no | yes |
| DAB2_HUMAN | [view interactions] | Low throughput | no | yes |
| CSK22_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| WEE1_HUMAN | [view interactions] | Low throughput | no | yes |
| PLK1_HUMAN | [view interactions] | Low throughput | no | yes |
| CDC27_HUMAN | [view interactions] | Low throughput | no | yes |
| PMYT1_HUMAN | [view interactions] | Low throughput | no | no |
| MPIP3_HUMAN | [view interactions] | Low throughput | no | yes |
| JUN_HUMAN | [view interactions] | Low throughput | no | yes |
| BCL2_HUMAN | [view interactions] | Low throughput | no | no |
| RAB4A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KI20B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RPB1_HUMAN | [view interactions] | Low throughput | no | no |
| MYT1_HUMAN | [view interactions] | Low throughput | no | yes |
| SMAD2_HUMAN | [view interactions] | Low throughput | no | yes |
| FOXO4_HUMAN | [view interactions] | Low throughput | no | no |
| MCL1_HUMAN | [view interactions] | Low throughput | no | yes |
| CDN1B_HUMAN | [view interactions] | Low throughput | no | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EGR1_HUMAN | [view interactions] | Low throughput | no | yes |
| PITX1_HUMAN | [view interactions] | Low throughput | no | yes |
| PIM1_HUMAN | [view interactions] | Low throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | Low throughput | no | yes |
| RUNX3_HUMAN | [view interactions] | Low throughput | no | no |
| BCL6_HUMAN | [view interactions] | Low throughput | no | no |
| DAXX_HUMAN | [view interactions] | Low throughput | no | yes |
| TF65_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IKBA_HUMAN | [view interactions] | Low throughput | no | yes |
| AATF_HUMAN | [view interactions] | Low throughput | no | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| IRF3_HUMAN | [view interactions] | Low throughput | no | yes |
| P73_HUMAN | [view interactions] | Low throughput | no | no |
| SYUA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TAU_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SNCAP_HUMAN | [view interactions] | Low throughput | no | no |
| MYB_HUMAN | [view interactions] | Low throughput | no | yes |
| SP1_HUMAN | [view interactions] | Low throughput | no | yes |
| PPARG_HUMAN | [view interactions] | Low throughput | no | yes |
| SGK1_HUMAN | [view interactions] | Low throughput | no | yes |
| REST_HUMAN | [view interactions] | Low throughput | no | yes |
| ATCAY_HUMAN | [view interactions] | Low throughput | no | no |
| SPT5H_HUMAN | [view interactions] | Low throughput | no | yes |
| FADD_HUMAN | [view interactions] | Low throughput | no | yes |
| FAP20_HUMAN | [view interactions] | Low throughput | no | no |
| GSK3A_HUMAN | [view interactions] | Low throughput | no | yes |
| TRI59_HUMAN | [view interactions] | Low throughput | no | no |
| KPYM_HUMAN | [view interactions] | Low throughput | no | yes |
| P53_HUMAN | [view interactions] | Low throughput | no | no |
| STK3_HUMAN | [view interactions] | Low throughput | no | yes |
| ST4A1_HUMAN | [view interactions] | Low throughput | no | yes |
| HIF1A_HUMAN | [view interactions] | Low throughput | no | no |
| M3K8_HUMAN | [view interactions] | Low throughput | no | yes |
| TLE1_HUMAN | [view interactions] | Low throughput | no | yes |
| MP2K1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HIPK2_HUMAN | [view interactions] | Low throughput | no | yes |
| CCNE1_HUMAN | [view interactions] | Low throughput | no | no |
| HES1_HUMAN | [view interactions] | Low throughput | no | no |
| NEK6_HUMAN | [view interactions] | Low throughput | no | yes |
| GEPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GABPA_HUMAN | [view interactions] | Low throughput | no | no |
| STIL_HUMAN | [view interactions] | Low throughput | no | no |
| PML_HUMAN | [view interactions] | Low throughput | no | yes |
| RED1_HUMAN | [view interactions] | Low throughput | no | no |
| CDK10_HUMAN | [view interactions] | Low throughput | no | no |
| FOXC2_HUMAN | [view interactions] | Low throughput | no | no |
| RUNX2_HUMAN | [view interactions] | Low throughput | no | no |
| HOME1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SP140_HUMAN | [view interactions] | Low throughput | no | no |
| NFAC2_HUMAN | [view interactions] | Low throughput | no | yes |
| MP2K2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RARA_HUMAN | [view interactions] | Low throughput | no | no |
| RAF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NANP8_HUMAN | [view interactions] | Low throughput | no | no |
| NANOG_HUMAN | [view interactions] | Low throughput | no | no |
| MYC_HUMAN | [view interactions] | Low throughput | no | yes |
| BARD1_HUMAN | [view interactions] | Low throughput | no | yes |
| NOTC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TOP2A_HUMAN | [view interactions] | Low throughput | no | no |
| CSK21_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| P63_HUMAN | [view interactions] | Low throughput | no | no |
| IRAK1_HUMAN | [view interactions] | Low throughput | no | yes |
| GRM5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| BRCA1_HUMAN | [view interactions] | Low throughput | no | yes |
| HDAC3_HUMAN | [view interactions] | Low throughput | no | yes |
| NCOR2_HUMAN | [view interactions] | Low throughput | no | yes |
| SMAD3_HUMAN | [view interactions] | Low throughput | no | yes |
| CDK2_HUMAN | [view interactions] | Low throughput | no | yes |
| EP300_HUMAN | [view interactions] | Low throughput | no | yes |
| CPEB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NHRF1_HUMAN | [view interactions] | Low throughput | no | no |
| SEPT9_HUMAN | [view interactions] | Low throughput | no | no |
| IPP2_HUMAN | [view interactions] | Low throughput | no | no |
| MPIP1_HUMAN | [view interactions] | Low throughput | no | no |
| ATP68_HUMAN | [view interactions] | Low throughput | no | yes |
| INCE_HUMAN | [view interactions] | Low throughput | no | no |
| NEK2_HUMAN | [view interactions] | Low throughput | no | no |
| BTG2_HUMAN | [view interactions] | Low throughput | no | yes |
| NONO_HUMAN | [view interactions] | Low throughput | no | yes |
| KR106_HUMAN | [view interactions] | High throughput | no | no |
| AATM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAX6_HUMAN | [view interactions] | High throughput | no | no |
| FUBP1_HUMAN | [view interactions] | High throughput | no | yes |
| TENS2_HUMAN | [view interactions] | High throughput | no | no |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| SRCRL_HUMAN | [view interactions] | High throughput | no | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| E2F4_HUMAN | [view interactions] | High throughput | no | no |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| FOXN1_HUMAN | [view interactions] | High throughput | no | no |
| NUP43_HUMAN | [view interactions] | High throughput | no | yes |
| GG6L9_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| KRT34_HUMAN | [view interactions] | High throughput | no | no |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHG2_HUMAN | [view interactions] | High throughput | no | no |
| NUP35_HUMAN | [view interactions] | High throughput | no | yes |
| ZBTB2_HUMAN | [view interactions] | High throughput | no | yes |
| RB8NL_HUMAN | [view interactions] | High throughput | no | no |
| TRI27_HUMAN | [view interactions] | High throughput | no | yes |
| GMEB2_HUMAN | [view interactions] | High throughput | no | yes |
| NR4A3_HUMAN | [view interactions] | High throughput | no | yes |
| PBX1_HUMAN | [view interactions] | High throughput | no | yes |
| IN80E_HUMAN | [view interactions] | High throughput | no | yes |
| CC88B_HUMAN | [view interactions] | High throughput | no | no |
| ETV6_HUMAN | [view interactions] | High throughput | no | no |
| ZN526_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| ZN768_HUMAN | [view interactions] | High throughput | no | yes |
| KRT37_HUMAN | [view interactions] | High throughput | no | no |
| KR108_HUMAN | [view interactions] | High throughput | no | no |
| AF17_HUMAN | [view interactions] | High throughput | no | yes |
| KRA59_HUMAN | [view interactions] | High throughput | no | no |
| CCDC6_HUMAN | [view interactions] | High throughput | no | yes |
| MEOX1_HUMAN | [view interactions] | High throughput | no | no |
| MYF5_HUMAN | [view interactions] | High throughput | no | no |
| SELV_HUMAN | [view interactions] | High throughput | no | no |
| PDLI7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FOSL1_HUMAN | [view interactions] | High throughput | no | yes |
| UBX2B_HUMAN | [view interactions] | High throughput | no | no |
| FUCO2_HUMAN | [view interactions] | High throughput | no | no |
| ZN449_HUMAN | [view interactions] | High throughput | no | no |
| SCAI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARI5A_HUMAN | [view interactions] | High throughput | no | yes |
| HXA1_HUMAN | [view interactions] | High throughput | no | no |
| ZBT42_HUMAN | [view interactions] | High throughput | no | yes |
| AJUBA_HUMAN | [view interactions] | High throughput | no | yes |
| PLAL2_HUMAN | [view interactions] | High throughput | no | no |
| TFPT_HUMAN | [view interactions] | High throughput | no | yes |
| NGAL_HUMAN | [view interactions] | High throughput | no | no |
| FHL5_HUMAN | [view interactions] | High throughput | no | no |
| NDF4_HUMAN | [view interactions] | High throughput | no | no |
| NELFA_HUMAN | [view interactions] | High throughput | no | yes |
| RN208_HUMAN | [view interactions] | High throughput | no | no |
| CC036_HUMAN | [view interactions] | High throughput | no | no |
| GP152_HUMAN | [view interactions] | High throughput | no | no |
| ZN446_HUMAN | [view interactions] | High throughput | no | yes |
| SOCS3_HUMAN | [view interactions] | High throughput | no | yes |
| DDX24_HUMAN | [view interactions] | High throughput | no | yes |
| LEPR_HUMAN | [view interactions] | High throughput | no | no |
| KLH20_HUMAN | [view interactions] | High throughput | no | yes |
| GPAA1_HUMAN | [view interactions] | High throughput | no | yes |
| PTOV1_HUMAN | [view interactions] | High throughput | no | yes |
| ZCH10_HUMAN | [view interactions] | High throughput | no | yes |
| CHSS2_HUMAN | [view interactions] | High throughput | no | yes |
| MTFR1_HUMAN | [view interactions] | High throughput | no | yes |
| GGA2_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPC_HUMAN | [view interactions] | High throughput | no | yes |
| CTIP_HUMAN | [view interactions] | High throughput | no | no |
| CEP19_HUMAN | [view interactions] | High throughput | no | no |
| BAG6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATL4_HUMAN | [view interactions] | High throughput | no | yes |
| HOMEZ_HUMAN | [view interactions] | High throughput | no | no |
| CCD33_HUMAN | [view interactions] | High throughput | no | no |
| AMOT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KR101_HUMAN | [view interactions] | High throughput | no | no |
| KR103_HUMAN | [view interactions] | High throughput | no | no |
| EYA2_HUMAN | [view interactions] | High throughput | no | yes |
| EFS_HUMAN | [view interactions] | High throughput | no | no |
| TOX3_HUMAN | [view interactions] | High throughput | no | yes |
| ATN1_HUMAN | [view interactions] | High throughput | no | yes |
| BRD8_HUMAN | [view interactions] | High throughput | no | yes |
| BC11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTG16_HUMAN | [view interactions] | High throughput | no | yes |
| HTF4_HUMAN | [view interactions] | High throughput | no | yes |
| KIFC3_HUMAN | [view interactions] | High throughput | no | no |
| SCYL1_HUMAN | [view interactions] | High throughput | no | yes |
| FRS2_HUMAN | [view interactions] | High throughput | no | no |
| FOXI1_HUMAN | [view interactions] | High throughput | no | no |
| ZN783_HUMAN | [view interactions] | High throughput | no | no |
| SPN90_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCTD7_HUMAN | [view interactions] | High throughput | no | no |
| CC153_HUMAN | [view interactions] | High throughput | no | no |
| GRSF1_HUMAN | [view interactions] | High throughput | no | yes |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| SSBP2_HUMAN | [view interactions] | High throughput | no | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| SSBP4_HUMAN | [view interactions] | High throughput | no | no |
| M3K11_HUMAN | [view interactions] | High throughput | no | yes |
| MOCS1_HUMAN | [view interactions] | High throughput | no | yes |
| DUS6_HUMAN | [view interactions] | High throughput | no | yes |
| IPKB_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| UHRF2_HUMAN | [view interactions] | High throughput | no | no |
| SHKB1_HUMAN | [view interactions] | High throughput | no | yes |
| NUP98_HUMAN | [view interactions] | High throughput | no | no |
| APLP1_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| ATPB_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CREL2_HUMAN | [view interactions] | High throughput | no | yes |
| BACH1_HUMAN | [view interactions] | High throughput | no | no |
| LRIF1_HUMAN | [view interactions] | High throughput | no | yes |
| CHSP1_HUMAN | [view interactions] | High throughput | no | yes |
| CASP6_HUMAN | [view interactions] | High throughput | no | no |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| CC90B_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| CENPB_HUMAN | [view interactions] | High throughput | no | yes |
| COBA2_HUMAN | [view interactions] | High throughput | no | no |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPNE6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| CSAD_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| DDAH2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| DEAF1_HUMAN | [view interactions] | High throughput | no | yes |
| DIDO1_HUMAN | [view interactions] | High throughput | no | yes |
| DMPK_HUMAN | [view interactions] | High throughput | no | yes |
| VPS16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC1I1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPB4_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3G_HUMAN | [view interactions] | High throughput | no | yes |
| SPT6H_HUMAN | [view interactions] | High throughput | no | yes |
| KIF5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| KMT2B_HUMAN | [view interactions] | High throughput | no | no |
| ASHWN_HUMAN | [view interactions] | High throughput | no | yes |
| T2EB_HUMAN | [view interactions] | High throughput | no | yes |
| SYQ_HUMAN | [view interactions] | High throughput | no | yes |
| RL35A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RPR1B_HUMAN | [view interactions] | High throughput | no | yes |
| TRM2A_HUMAN | [view interactions] | High throughput | no | yes |
| APBA1_HUMAN | [view interactions] | High throughput | no | no |
| TSC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN684_HUMAN | [view interactions] | High throughput | no | no |
| U119A_HUMAN | [view interactions] | High throughput | no | no |
| OSGEP_HUMAN | [view interactions] | High throughput | no | yes |
| WIZ_HUMAN | [view interactions] | High throughput | no | yes |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| AXIN1_HUMAN | [view interactions] | High throughput | no | yes |
| SLX4_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| SIK1_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RB_HUMAN | [view interactions] | High throughput | no | yes |
| KEAP1_HUMAN | [view interactions] | High throughput | no | yes |
| BCLF1_HUMAN | [view interactions] | High throughput | no | yes |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| CDK12_HUMAN | [view interactions] | High throughput | no | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| MED1_HUMAN | [view interactions] | High throughput | no | no |
| SNR27_HUMAN | [view interactions] | High throughput | no | yes |
| TR150_HUMAN | [view interactions] | High throughput | no | yes |
| PI42A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TLE3_HUMAN | [view interactions] | High throughput | no | yes |
| CP1A1_HUMAN | [view interactions] | High throughput | no | yes |
| DDX17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX3X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHX15_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| STPAP_HUMAN | [view interactions] | High throughput | no | no |
| G3BP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| PABP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRP8_HUMAN | [view interactions] | High throughput | no | yes |
| RNPS1_HUMAN | [view interactions] | High throughput | no | yes |
| SFPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRS11_HUMAN | [view interactions] | High throughput | no | yes |
| HLAC_HUMAN | [view interactions] | High throughput | no | no |
| SRRM1_HUMAN | [view interactions] | High throughput | no | yes |
| EIF1B_HUMAN | [view interactions] | High throughput | no | no |
| SRRM2_HUMAN | [view interactions] | High throughput | no | yes |
| VHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| U2AF2_HUMAN | [view interactions] | High throughput | no | yes |
| TRM7_HUMAN | [view interactions] | High throughput | no | yes |
| U520_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| DDB1_HUMAN | [view interactions] | High throughput | no | yes |
| EPB41_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WRIP1_HUMAN | [view interactions] | High throughput | no | yes |
| CD11B_HUMAN | [view interactions] | High throughput | no | yes |
| CD11A_HUMAN | [view interactions] | High throughput | no | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XRCC6_HUMAN | [view interactions] | High throughput | no | yes |
| CCNK_HUMAN | [view interactions] | High throughput | no | yes |
| MAP1S_HUMAN | [view interactions] | High throughput | no | no |
| UBQL4_HUMAN | [view interactions] | High throughput | no | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| REPS1_HUMAN | [view interactions] | High throughput | no | yes |
| MEOX2_HUMAN | [view interactions] | High throughput | no | no |
| CHAP1_HUMAN | [view interactions] | High throughput | no | yes |
| CEP55_HUMAN | [view interactions] | High throughput | no | yes |
| CAPR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARHGF_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBCD4_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT7B_HUMAN | [view interactions] | High throughput | no | no |
| TFG_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT22_HUMAN | [view interactions] | High throughput | no | no |
| ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FOXP2_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT14_HUMAN | [view interactions] | High throughput | no | yes |
| DAB1_HUMAN | [view interactions] | High throughput | no | yes |
| KRT38_HUMAN | [view interactions] | High throughput | no | no |
| ITF2_HUMAN | [view interactions] | High throughput | no | yes |
| CBS_HUMAN | [view interactions] | High throughput | no | yes |
| NUP62_HUMAN | [view interactions] | High throughput | no | yes |
| KR107_HUMAN | [view interactions] | High throughput | no | no |
| KR109_HUMAN | [view interactions] | High throughput | no | no |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRAF2_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF1_HUMAN | [view interactions] | High throughput | no | no |
| NDUA7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IKZF1_HUMAN | [view interactions] | High throughput | no | no |
| UBE2A_HUMAN | [view interactions] | High throughput | no | no |
| PP2AA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1H1_HUMAN | [view interactions] | High throughput | no | no |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TRIP6_HUMAN | [view interactions] | High throughput | no | yes |
| VATB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAB2_HUMAN | [view interactions] | High throughput | no | yes |
| FKB1A_HUMAN | [view interactions] | High throughput | no | yes |
| CC184_HUMAN | [view interactions] | High throughput | no | no |
| FKB1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTUS2_HUMAN | [view interactions] | High throughput | no | yes |
| HINT1_HUMAN | [view interactions] | High throughput | no | yes |
| K1C40_HUMAN | [view interactions] | High throughput | no | no |
| MSI2H_HUMAN | [view interactions] | High throughput | no | yes |
| ANR40_HUMAN | [view interactions] | High throughput | no | yes |
| NDKB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAI1_HUMAN | [view interactions] | High throughput | no | yes |
| PCBP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAB3_HUMAN | [view interactions] | High throughput | no | yes |
| COF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CBY2_HUMAN | [view interactions] | High throughput | no | no |
| DAZP1_HUMAN | [view interactions] | High throughput | no | yes |
| PNMA1_HUMAN | [view interactions] | High throughput | no | yes |
| FABP5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZMIZ2_HUMAN | [view interactions] | High throughput | no | yes |
| GPX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CEP76_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC1_HUMAN | [view interactions] | High throughput | no | no |
| RBPMS_HUMAN | [view interactions] | High throughput | no | no |
| CH10_HUMAN | [view interactions] | High throughput | no | yes |
| CNKR1_HUMAN | [view interactions] | High throughput | no | no |
| SNX12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JKIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNX3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZBTB9_HUMAN | [view interactions] | High throughput | no | no |
| SPRE_HUMAN | [view interactions] | High throughput | no | yes |
| PRRC1_HUMAN | [view interactions] | High throughput | no | yes |
| TAGL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HEXI2_HUMAN | [view interactions] | High throughput | no | yes |
| TAGL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MDFI_HUMAN | [view interactions] | High throughput | no | no |
| PPIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THAP7_HUMAN | [view interactions] | High throughput | no | no |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| SSBP3_HUMAN | [view interactions] | High throughput | no | no |
| TBCA_HUMAN | [view interactions] | High throughput | no | yes |
| KRA42_HUMAN | [view interactions] | High throughput | no | no |
| ZO1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP2AB_HUMAN | [view interactions] | High throughput | no | yes |
| IKZF3_HUMAN | [view interactions] | High throughput | no | no |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| T22D4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 2ABA_HUMAN | [view interactions] | High throughput | no | yes |