PIN1_HUMAN
Evidence for PS localization
Functions
Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs (PubMed, PubMed, PubMed). By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes (PubMed, PubMed, PubMed). Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed). May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed, PubMed). Upon IL33-induced lung inflammation, catalyzes cis-trans isomerization of phosphorylated IRAK3/IRAK-M, inducing IRAK3 stabilization, nuclear translocation and expression of pro-inflammatory genes in dendritic cells (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PIN1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 30.1205 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 30.1205 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 28.9157 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 27.7108 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 27.7108 | 5 | no |
| GO:0005524 | ATP binding | 26.5060 | 5 | no |
| GO:0003723 | RNA binding | 21.6867 | 4 | no |
| GO:0019900 | kinase binding | 20.4819 | 4 | yes |
| GO:0019901 | protein kinase binding | 18.0723 | 5 | yes |
| GO:0045309 | protein phosphorylated amino acid binding | 6.0241 | 4 | yes |
| GO:0048156 | tau protein binding | 4.8193 | 4 | yes |
| GO:0050815 | phosphoserine residue binding | 3.6145 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PIN1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 69.8795 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 68.6747 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 67.4699 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 66.2651 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 66.2651 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 65.0602 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 50.6024 | 4 | yes |
| GO:0010646 | regulation of cell communication | 50.6024 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 50.6024 | 4 | yes |
| GO:0010468 | regulation of gene expression | 49.3976 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 48.1928 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 48.1928 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 46.9880 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 46.9880 | 4 | yes |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 46.9880 | 5 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 45.7831 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 45.7831 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 45.7831 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 44.5783 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 44.5783 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 43.3735 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 43.3735 | 5 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 43.3735 | 5 | yes |
| GO:0051252 | regulation of RNA metabolic process | 42.1687 | 5 | yes |
| GO:0036211 | protein modification process | 37.3494 | 4 | yes |
| GO:0043412 | macromolecule modification | 37.3494 | 4 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 36.1446 | 6 | yes |
| GO:0031399 | regulation of protein modification process | 36.1446 | 6 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 36.1446 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 36.1446 | 6 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 34.9398 | 5 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 33.7349 | 6 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 33.7349 | 5 | yes |
| GO:0051049 | regulation of transport | 33.7349 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 32.5301 | 6 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 32.5301 | 4 | no |
| GO:0010941 | regulation of cell death | 32.5301 | 4 | no |
| GO:0008104 | protein localization | 32.5301 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 31.3253 | 4 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 31.3253 | 6 | yes |
| GO:0043067 | regulation of programmed cell death | 31.3253 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 30.1205 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 30.1205 | 6 | no |
| GO:0006996 | organelle organization | 30.1205 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 28.9157 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 28.9157 | 4 | yes |
| GO:0042325 | regulation of phosphorylation | 28.9157 | 7 | yes |
| GO:0060548 | negative regulation of cell death | 28.9157 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 27.7108 | 5 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 27.7108 | 6 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 27.7108 | 6 | yes |
| GO:0048585 | negative regulation of response to stimulus | 27.7108 | 4 | yes |
| GO:0051338 | regulation of transferase activity | 27.7108 | 4 | yes |
| GO:0043069 | negative regulation of programmed cell death | 27.7108 | 6 | no |
| GO:0001932 | regulation of protein phosphorylation | 26.5060 | 7 | yes |
| GO:0009967 | positive regulation of signal transduction | 26.5060 | 5 | yes |
| GO:0010648 | negative regulation of cell communication | 26.5060 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 26.5060 | 4 | yes |
| GO:0043085 | positive regulation of catalytic activity | 26.5060 | 4 | yes |
| GO:0043066 | negative regulation of apoptotic process | 26.5060 | 7 | no |
| GO:0071702 | organic substance transport | 26.5060 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 25.3012 | 5 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.3012 | 6 | yes |
| GO:0033043 | regulation of organelle organization | 25.3012 | 5 | yes |
| GO:0051254 | positive regulation of RNA metabolic process | 25.3012 | 6 | yes |
| GO:0060341 | regulation of cellular localization | 25.3012 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 24.0964 | 4 | yes |
| GO:0031401 | positive regulation of protein modification process | 24.0964 | 7 | yes |
| GO:0071705 | nitrogen compound transport | 24.0964 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 24.0964 | 5 | no |
| GO:0080134 | regulation of response to stress | 24.0964 | 4 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 22.8916 | 7 | yes |
| GO:0010562 | positive regulation of phosphorus metabolic process | 22.8916 | 6 | yes |
| GO:0042327 | positive regulation of phosphorylation | 22.8916 | 8 | yes |
| GO:0045937 | positive regulation of phosphate metabolic process | 22.8916 | 7 | yes |
| GO:0051094 | positive regulation of developmental process | 22.8916 | 4 | no |
| GO:0022607 | cellular component assembly | 22.8916 | 4 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 21.6867 | 8 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 21.6867 | 7 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 21.6867 | 7 | yes |
| GO:1903508 | positive regulation of nucleic acid-templated transcription | 21.6867 | 8 | yes |
| GO:0043549 | regulation of kinase activity | 21.6867 | 5 | no |
| GO:0009890 | negative regulation of biosynthetic process | 21.6867 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 21.6867 | 6 | no |
| GO:0042127 | regulation of cell population proliferation | 21.6867 | 4 | no |
| GO:0015031 | protein transport | 21.6867 | 4 | no |
| GO:0016310 | phosphorylation | 21.6867 | 5 | no |
| GO:0018193 | peptidyl-amino acid modification | 20.4819 | 5 | yes |
| GO:0032880 | regulation of protein localization | 20.4819 | 5 | yes |
| GO:0043408 | regulation of MAPK cascade | 20.4819 | 6 | yes |
| GO:0051347 | positive regulation of transferase activity | 20.4819 | 5 | yes |
| GO:0016070 | RNA metabolic process | 20.4819 | 5 | no |
| GO:0031400 | negative regulation of protein modification process | 20.4819 | 7 | no |
| GO:0090304 | nucleic acid metabolic process | 20.4819 | 4 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 20.4819 | 6 | no |
| GO:0006468 | protein phosphorylation | 20.4819 | 5 | no |
| GO:0071310 | cellular response to organic substance | 20.4819 | 4 | no |
| GO:0051336 | regulation of hydrolase activity | 19.2771 | 4 | yes |
| GO:0051726 | regulation of cell cycle | 16.8675 | 4 | yes |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | 15.6627 | 8 | yes |
| GO:0034330 | cell junction organization | 14.4578 | 4 | yes |
| GO:0009895 | negative regulation of catabolic process | 13.2530 | 5 | yes |
| GO:0034248 | regulation of cellular amide metabolic process | 13.2530 | 5 | yes |
| GO:0051345 | positive regulation of hydrolase activity | 13.2530 | 5 | yes |
| GO:0010564 | regulation of cell cycle process | 12.0482 | 5 | yes |
| GO:0030111 | regulation of Wnt signaling pathway | 12.0482 | 5 | yes |
| GO:1902532 | negative regulation of intracellular signal transduction | 12.0482 | 6 | yes |
| GO:0042176 | regulation of protein catabolic process | 10.8434 | 5 | yes |
| GO:2000145 | regulation of cell motility | 10.8434 | 4 | yes |
| GO:0007346 | regulation of mitotic cell cycle | 9.6386 | 5 | yes |
| GO:0043393 | regulation of protein binding | 9.6386 | 4 | yes |
| GO:0050808 | synapse organization | 9.6386 | 5 | yes |
| GO:0070372 | regulation of ERK1 and ERK2 cascade | 9.6386 | 7 | yes |
| GO:0035303 | regulation of dephosphorylation | 8.4337 | 7 | yes |
| GO:0035304 | regulation of protein dephosphorylation | 8.4337 | 7 | yes |
| GO:0042177 | negative regulation of protein catabolic process | 7.2289 | 6 | yes |
| GO:0051099 | positive regulation of binding | 7.2289 | 4 | yes |
| GO:0032091 | negative regulation of protein binding | 6.0241 | 5 | yes |
| GO:0032092 | positive regulation of protein binding | 6.0241 | 5 | yes |
| GO:0043087 | regulation of GTPase activity | 6.0241 | 5 | yes |
| GO:0043547 | positive regulation of GTPase activity | 6.0241 | 6 | yes |
| GO:0051100 | negative regulation of binding | 6.0241 | 4 | yes |
| GO:0060828 | regulation of canonical Wnt signaling pathway | 6.0241 | 6 | yes |
| GO:1903320 | regulation of protein modification by small protein conjugation or removal | 6.0241 | 7 | yes |
| GO:0030182 | neuron differentiation | 4.8193 | 4 | yes |
| GO:0034249 | negative regulation of cellular amide metabolic process | 4.8193 | 6 | yes |
| GO:0043409 | negative regulation of MAPK cascade | 4.8193 | 7 | yes |
| GO:0050821 | protein stabilization | 4.8193 | 4 | yes |
| GO:1900180 | regulation of protein localization to nucleus | 4.8193 | 6 | yes |
| GO:0000413 | protein peptidyl-prolyl isomerization | 3.6145 | 7 | yes |
| GO:0018208 | peptidyl-proline modification | 3.6145 | 6 | yes |
| GO:0030177 | positive regulation of Wnt signaling pathway | 3.6145 | 6 | yes |
| GO:0031396 | regulation of protein ubiquitination | 3.6145 | 8 | yes |
| GO:0035306 | positive regulation of dephosphorylation | 3.6145 | 8 | yes |
| GO:0035307 | positive regulation of protein dephosphorylation | 3.6145 | 8 | yes |
| GO:0036293 | response to decreased oxygen levels | 3.6145 | 4 | yes |
| GO:0040013 | negative regulation of locomotion | 3.6145 | 4 | yes |
| GO:0051302 | regulation of cell division | 3.6145 | 4 | yes |
| GO:1902991 | regulation of amyloid precursor protein catabolic process | 3.6145 | 6 | yes |
| GO:0007088 | regulation of mitotic nuclear division | 2.4096 | 6 | yes |
| GO:0031398 | positive regulation of protein ubiquitination | 2.4096 | 9 | yes |
| GO:0032465 | regulation of cytokinesis | 2.4096 | 5 | yes |
| GO:0051783 | regulation of nuclear division | 2.4096 | 6 | yes |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway | 2.4096 | 7 | yes |
| GO:0090287 | regulation of cellular response to growth factor stimulus | 2.4096 | 4 | yes |
| GO:1902003 | regulation of amyloid-beta formation | 2.4096 | 6 | yes |
| GO:1903322 | positive regulation of protein modification by small protein conjugation or removal | 2.4096 | 8 | yes |
| GO:2000146 | negative regulation of cell motility | 2.4096 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in PIN1_HUMAN |
|---|---|---|---|---|
| DOID:0050686 | organ system cancer | 2.4096 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| FOS_HUMAN | [view interactions] | Low throughput | no | yes |
| 1433S_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GLI1_HUMAN | [view interactions] | Low throughput | no | no |
| NCOA3_HUMAN | [view interactions] | Low throughput | no | yes |
| DAB2_HUMAN | [view interactions] | Low throughput | no | yes |
| CSK22_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| WEE1_HUMAN | [view interactions] | Low throughput | no | yes |
| PLK1_HUMAN | [view interactions] | Low throughput | no | yes |
| CDC27_HUMAN | [view interactions] | Low throughput | no | yes |
| PMYT1_HUMAN | [view interactions] | Low throughput | no | no |
| MPIP3_HUMAN | [view interactions] | Low throughput | no | yes |
| JUN_HUMAN | [view interactions] | Low throughput | no | yes |
| BCL2_HUMAN | [view interactions] | Low throughput | no | no |
| RAB4A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KI20B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RPB1_HUMAN | [view interactions] | Low throughput | no | no |
| MYT1_HUMAN | [view interactions] | Low throughput | no | yes |
| SMAD2_HUMAN | [view interactions] | Low throughput | no | yes |
| FOXO4_HUMAN | [view interactions] | Low throughput | no | no |
| MCL1_HUMAN | [view interactions] | Low throughput | no | yes |
| CDN1B_HUMAN | [view interactions] | Low throughput | no | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EGR1_HUMAN | [view interactions] | Low throughput | no | yes |
| PITX1_HUMAN | [view interactions] | Low throughput | no | yes |
| PIM1_HUMAN | [view interactions] | Low throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | Low throughput | no | yes |
| RUNX3_HUMAN | [view interactions] | Low throughput | no | no |
| BCL6_HUMAN | [view interactions] | Low throughput | no | no |
| DAXX_HUMAN | [view interactions] | Low throughput | no | yes |
| TF65_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IKBA_HUMAN | [view interactions] | Low throughput | no | yes |
| AATF_HUMAN | [view interactions] | Low throughput | no | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| IRF3_HUMAN | [view interactions] | Low throughput | no | yes |
| P73_HUMAN | [view interactions] | Low throughput | no | no |
| SYUA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TAU_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SNCAP_HUMAN | [view interactions] | Low throughput | no | no |
| MYB_HUMAN | [view interactions] | Low throughput | no | yes |
| SP1_HUMAN | [view interactions] | Low throughput | no | yes |
| PPARG_HUMAN | [view interactions] | Low throughput | no | yes |
| SGK1_HUMAN | [view interactions] | Low throughput | no | yes |
| REST_HUMAN | [view interactions] | Low throughput | no | yes |
| ATCAY_HUMAN | [view interactions] | Low throughput | no | no |
| FADD_HUMAN | [view interactions] | Low throughput | no | yes |
| SPT5H_HUMAN | [view interactions] | Low throughput | no | yes |
| FAP20_HUMAN | [view interactions] | Low throughput | no | no |
| GSK3A_HUMAN | [view interactions] | Low throughput | no | yes |
| TRI59_HUMAN | [view interactions] | Low throughput | no | no |
| KPYM_HUMAN | [view interactions] | Low throughput | no | yes |
| P53_HUMAN | [view interactions] | Low throughput | no | no |
| STK3_HUMAN | [view interactions] | Low throughput | no | yes |
| HIF1A_HUMAN | [view interactions] | Low throughput | no | no |
| ST4A1_HUMAN | [view interactions] | Low throughput | no | yes |
| TLE1_HUMAN | [view interactions] | Low throughput | no | yes |
| M3K8_HUMAN | [view interactions] | Low throughput | no | yes |
| HIPK2_HUMAN | [view interactions] | Low throughput | no | yes |
| MP2K1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HES1_HUMAN | [view interactions] | Low throughput | no | no |
| CCNE1_HUMAN | [view interactions] | Low throughput | no | no |
| NEK6_HUMAN | [view interactions] | Low throughput | no | yes |
| GEPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NFAC2_HUMAN | [view interactions] | Low throughput | no | yes |
| RARA_HUMAN | [view interactions] | Low throughput | no | no |
| PML_HUMAN | [view interactions] | Low throughput | no | yes |
| RED1_HUMAN | [view interactions] | Low throughput | no | no |
| CDK10_HUMAN | [view interactions] | Low throughput | no | no |
| FOXC2_HUMAN | [view interactions] | Low throughput | no | no |
| RUNX2_HUMAN | [view interactions] | Low throughput | no | no |
| HOME1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SP140_HUMAN | [view interactions] | Low throughput | no | no |
| MP2K2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NANOG_HUMAN | [view interactions] | Low throughput | no | no |
| NANP8_HUMAN | [view interactions] | Low throughput | no | no |
| MYC_HUMAN | [view interactions] | Low throughput | no | yes |
| BARD1_HUMAN | [view interactions] | Low throughput | no | yes |
| NOTC1_HUMAN | [view interactions] | Low throughput | no | yes |
| TOP2A_HUMAN | [view interactions] | Low throughput | no | no |
| CSK21_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| P63_HUMAN | [view interactions] | Low throughput | no | no |
| IRAK1_HUMAN | [view interactions] | Low throughput | no | yes |
| GRM5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| BRCA1_HUMAN | [view interactions] | Low throughput | no | yes |
| HDAC3_HUMAN | [view interactions] | Low throughput | no | yes |
| NCOR2_HUMAN | [view interactions] | Low throughput | no | yes |
| CDK2_HUMAN | [view interactions] | Low throughput | no | yes |
| EP300_HUMAN | [view interactions] | Low throughput | no | yes |
| SMAD3_HUMAN | [view interactions] | Low throughput | no | yes |
| CPEB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NHRF1_HUMAN | [view interactions] | Low throughput | no | no |
| SEPT9_HUMAN | [view interactions] | Low throughput | no | no |
| KCND2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KRT34_HUMAN | [view interactions] | High throughput | no | no |
| PKHG2_HUMAN | [view interactions] | High throughput | no | no |
| NUP35_HUMAN | [view interactions] | High throughput | no | yes |
| ZBTB2_HUMAN | [view interactions] | High throughput | no | yes |
| RB8NL_HUMAN | [view interactions] | High throughput | no | no |
| TRI27_HUMAN | [view interactions] | High throughput | no | yes |
| GMEB2_HUMAN | [view interactions] | High throughput | no | yes |
| NR4A3_HUMAN | [view interactions] | High throughput | no | yes |
| PBX1_HUMAN | [view interactions] | High throughput | no | yes |
| IN80E_HUMAN | [view interactions] | High throughput | no | yes |
| CC88B_HUMAN | [view interactions] | High throughput | no | no |
| ETV6_HUMAN | [view interactions] | High throughput | no | no |
| ZN526_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| ZN768_HUMAN | [view interactions] | High throughput | no | yes |
| KRT37_HUMAN | [view interactions] | High throughput | no | no |
| KR108_HUMAN | [view interactions] | High throughput | no | no |
| AF17_HUMAN | [view interactions] | High throughput | no | yes |
| KRA59_HUMAN | [view interactions] | High throughput | no | no |
| CCDC6_HUMAN | [view interactions] | High throughput | no | yes |
| MEOX1_HUMAN | [view interactions] | High throughput | no | no |
| MYF5_HUMAN | [view interactions] | High throughput | no | no |
| SELV_HUMAN | [view interactions] | High throughput | no | no |
| PDLI7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FOSL1_HUMAN | [view interactions] | High throughput | no | yes |
| UBX2B_HUMAN | [view interactions] | High throughput | no | no |
| FUCO2_HUMAN | [view interactions] | High throughput | no | no |
| ZN449_HUMAN | [view interactions] | High throughput | no | no |
| ARI5A_HUMAN | [view interactions] | High throughput | no | yes |
| SCAI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HXA1_HUMAN | [view interactions] | High throughput | no | no |
| ZBT42_HUMAN | [view interactions] | High throughput | no | yes |
| AJUBA_HUMAN | [view interactions] | High throughput | no | yes |
| PLAL2_HUMAN | [view interactions] | High throughput | no | no |
| TFPT_HUMAN | [view interactions] | High throughput | no | yes |
| NGAL_HUMAN | [view interactions] | High throughput | no | no |
| FHL5_HUMAN | [view interactions] | High throughput | no | no |
| NDF4_HUMAN | [view interactions] | High throughput | no | no |
| NELFA_HUMAN | [view interactions] | High throughput | no | yes |
| RN208_HUMAN | [view interactions] | High throughput | no | no |
| CC036_HUMAN | [view interactions] | High throughput | no | no |
| GP152_HUMAN | [view interactions] | High throughput | no | no |
| ZN446_HUMAN | [view interactions] | High throughput | no | yes |
| SOCS3_HUMAN | [view interactions] | High throughput | no | yes |
| DDX24_HUMAN | [view interactions] | High throughput | no | yes |
| LEPR_HUMAN | [view interactions] | High throughput | no | no |
| KLH20_HUMAN | [view interactions] | High throughput | no | yes |
| GPAA1_HUMAN | [view interactions] | High throughput | no | yes |
| PTOV1_HUMAN | [view interactions] | High throughput | no | yes |
| ZCH10_HUMAN | [view interactions] | High throughput | no | yes |
| CHSS2_HUMAN | [view interactions] | High throughput | no | yes |
| MTFR1_HUMAN | [view interactions] | High throughput | no | yes |
| GGA2_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPC_HUMAN | [view interactions] | High throughput | no | yes |
| CTIP_HUMAN | [view interactions] | High throughput | no | no |
| CEP19_HUMAN | [view interactions] | High throughput | no | no |
| BAG6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARHGF_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATL4_HUMAN | [view interactions] | High throughput | no | yes |
| HOMEZ_HUMAN | [view interactions] | High throughput | no | no |
| CCD33_HUMAN | [view interactions] | High throughput | no | no |
| AMOT_HUMAN | [view interactions] | High throughput | no | no |
| KR101_HUMAN | [view interactions] | High throughput | no | no |
| KR103_HUMAN | [view interactions] | High throughput | no | no |
| EYA2_HUMAN | [view interactions] | High throughput | no | yes |
| EFS_HUMAN | [view interactions] | High throughput | no | no |
| TOX3_HUMAN | [view interactions] | High throughput | no | yes |
| ATN1_HUMAN | [view interactions] | High throughput | no | yes |
| BRD8_HUMAN | [view interactions] | High throughput | no | yes |
| BC11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTG16_HUMAN | [view interactions] | High throughput | no | yes |
| HTF4_HUMAN | [view interactions] | High throughput | no | yes |
| KIFC3_HUMAN | [view interactions] | High throughput | no | no |
| SCYL1_HUMAN | [view interactions] | High throughput | no | yes |
| FRS2_HUMAN | [view interactions] | High throughput | no | no |
| FOXI1_HUMAN | [view interactions] | High throughput | no | no |
| ZN783_HUMAN | [view interactions] | High throughput | no | no |
| SPN90_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCTD7_HUMAN | [view interactions] | High throughput | no | no |
| CC153_HUMAN | [view interactions] | High throughput | no | no |
| GRSF1_HUMAN | [view interactions] | High throughput | no | yes |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| SSBP2_HUMAN | [view interactions] | High throughput | no | yes |
| SSBP4_HUMAN | [view interactions] | High throughput | no | no |
| M3K11_HUMAN | [view interactions] | High throughput | no | yes |
| DUS6_HUMAN | [view interactions] | High throughput | no | yes |
| MOCS1_HUMAN | [view interactions] | High throughput | no | yes |
| IPKB_HUMAN | [view interactions] | High throughput | no | yes |
| UHRF2_HUMAN | [view interactions] | High throughput | no | no |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| NUP98_HUMAN | [view interactions] | High throughput | no | no |
| SHKB1_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| APLP1_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPB_HUMAN | [view interactions] | High throughput | no | yes |
| BACH1_HUMAN | [view interactions] | High throughput | no | no |
| CREL2_HUMAN | [view interactions] | High throughput | no | yes |
| LRIF1_HUMAN | [view interactions] | High throughput | no | yes |
| CHSP1_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| CASP6_HUMAN | [view interactions] | High throughput | no | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| CC90B_HUMAN | [view interactions] | High throughput | no | yes |
| CENPB_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COBA2_HUMAN | [view interactions] | High throughput | no | no |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| CPNE6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| CSAD_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| DDAH2_HUMAN | [view interactions] | High throughput | no | yes |
| DIDO1_HUMAN | [view interactions] | High throughput | no | yes |
| DEAF1_HUMAN | [view interactions] | High throughput | no | yes |
| VPS16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DMPK_HUMAN | [view interactions] | High throughput | no | yes |
| RPB4_HUMAN | [view interactions] | High throughput | no | yes |
| DC1I1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPT6H_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3G_HUMAN | [view interactions] | High throughput | no | yes |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| KIF5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASHWN_HUMAN | [view interactions] | High throughput | no | yes |
| KMT2B_HUMAN | [view interactions] | High throughput | no | no |
| T2EB_HUMAN | [view interactions] | High throughput | no | yes |
| RL35A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYQ_HUMAN | [view interactions] | High throughput | no | yes |
| RPR1B_HUMAN | [view interactions] | High throughput | no | yes |
| APBA1_HUMAN | [view interactions] | High throughput | no | no |
| TRM2A_HUMAN | [view interactions] | High throughput | no | yes |
| ZN684_HUMAN | [view interactions] | High throughput | no | no |
| TSC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OSGEP_HUMAN | [view interactions] | High throughput | no | yes |
| U119A_HUMAN | [view interactions] | High throughput | no | no |
| WIZ_HUMAN | [view interactions] | High throughput | no | yes |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AXIN1_HUMAN | [view interactions] | High throughput | no | yes |
| SLX4_HUMAN | [view interactions] | High throughput | no | yes |
| BCLF1_HUMAN | [view interactions] | High throughput | no | yes |
| CDK12_HUMAN | [view interactions] | High throughput | no | yes |
| MED1_HUMAN | [view interactions] | High throughput | no | no |
| TR150_HUMAN | [view interactions] | High throughput | no | yes |
| TLE3_HUMAN | [view interactions] | High throughput | no | yes |
| DDX17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX3X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHX15_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| STPAP_HUMAN | [view interactions] | High throughput | no | no |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| G3BP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNR27_HUMAN | [view interactions] | High throughput | no | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| PI42A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CP1A1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| SYAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| PABP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRP8_HUMAN | [view interactions] | High throughput | no | yes |
| RNPS1_HUMAN | [view interactions] | High throughput | no | yes |
| SFPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRS11_HUMAN | [view interactions] | High throughput | no | yes |
| SRRM1_HUMAN | [view interactions] | High throughput | no | yes |
| SRRM2_HUMAN | [view interactions] | High throughput | no | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| U2AF2_HUMAN | [view interactions] | High throughput | no | yes |
| U520_HUMAN | [view interactions] | High throughput | no | yes |
| RL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDB1_HUMAN | [view interactions] | High throughput | no | yes |
| WRIP1_HUMAN | [view interactions] | High throughput | no | yes |
| CD11B_HUMAN | [view interactions] | High throughput | no | yes |
| PAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CD11A_HUMAN | [view interactions] | High throughput | no | yes |
| HLAC_HUMAN | [view interactions] | High throughput | no | no |
| XRCC6_HUMAN | [view interactions] | High throughput | no | yes |
| EIF1B_HUMAN | [view interactions] | High throughput | no | no |
| MAP1S_HUMAN | [view interactions] | High throughput | no | no |
| VHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRM7_HUMAN | [view interactions] | High throughput | no | yes |
| REPS1_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF6_HUMAN | [view interactions] | High throughput | no | yes |
| CHAP1_HUMAN | [view interactions] | High throughput | no | yes |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| CAPR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPB41_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBCD4_HUMAN | [view interactions] | High throughput | no | yes |
| TFG_HUMAN | [view interactions] | High throughput | no | yes |
| ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNK_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL4_HUMAN | [view interactions] | High throughput | no | yes |
| MEOX2_HUMAN | [view interactions] | High throughput | no | no |
| CEP55_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT7B_HUMAN | [view interactions] | High throughput | no | no |
| NDUA7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBT22_HUMAN | [view interactions] | High throughput | no | no |
| UBE2A_HUMAN | [view interactions] | High throughput | no | no |
| FOXP2_HUMAN | [view interactions] | High throughput | no | yes |
| PP2AA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBT14_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| DAB1_HUMAN | [view interactions] | High throughput | no | yes |
| VATB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KRT38_HUMAN | [view interactions] | High throughput | no | no |
| FKB1A_HUMAN | [view interactions] | High throughput | no | yes |
| ITF2_HUMAN | [view interactions] | High throughput | no | yes |
| FKB1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBS_HUMAN | [view interactions] | High throughput | no | yes |
| HINT1_HUMAN | [view interactions] | High throughput | no | yes |
| NUP62_HUMAN | [view interactions] | High throughput | no | yes |
| MSI2H_HUMAN | [view interactions] | High throughput | no | yes |
| KR107_HUMAN | [view interactions] | High throughput | no | no |
| NDKB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KR109_HUMAN | [view interactions] | High throughput | no | no |
| PCBP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRAF2_HUMAN | [view interactions] | High throughput | no | yes |
| DAZP1_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF1_HUMAN | [view interactions] | High throughput | no | no |
| FABP5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IKZF1_HUMAN | [view interactions] | High throughput | no | no |
| GPX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NONO_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC1_HUMAN | [view interactions] | High throughput | no | no |
| K1H1_HUMAN | [view interactions] | High throughput | no | no |
| CH10_HUMAN | [view interactions] | High throughput | no | yes |
| TRIP6_HUMAN | [view interactions] | High throughput | no | yes |
| SNX12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAB2_HUMAN | [view interactions] | High throughput | no | yes |
| SNX3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CC184_HUMAN | [view interactions] | High throughput | no | no |
| SPRE_HUMAN | [view interactions] | High throughput | no | yes |
| MTUS2_HUMAN | [view interactions] | High throughput | no | yes |
| TAGL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| K1C40_HUMAN | [view interactions] | High throughput | no | no |
| TAGL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANR40_HUMAN | [view interactions] | High throughput | no | yes |
| PPIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAI1_HUMAN | [view interactions] | High throughput | no | yes |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| TAB3_HUMAN | [view interactions] | High throughput | no | yes |
| TBCA_HUMAN | [view interactions] | High throughput | no | yes |
| CBY2_HUMAN | [view interactions] | High throughput | no | no |
| ZO1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PNMA1_HUMAN | [view interactions] | High throughput | no | yes |
| PP2AB_HUMAN | [view interactions] | High throughput | no | yes |
| ZMIZ2_HUMAN | [view interactions] | High throughput | no | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CEP76_HUMAN | [view interactions] | High throughput | no | yes |
| 2ABA_HUMAN | [view interactions] | High throughput | no | yes |
| RBPMS_HUMAN | [view interactions] | High throughput | no | no |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| CNKR1_HUMAN | [view interactions] | High throughput | no | no |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| JKIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| ZBTB9_HUMAN | [view interactions] | High throughput | no | no |
| PRRC1_HUMAN | [view interactions] | High throughput | no | yes |
| HEXI2_HUMAN | [view interactions] | High throughput | no | yes |
| MDFI_HUMAN | [view interactions] | High throughput | no | no |
| THAP7_HUMAN | [view interactions] | High throughput | no | no |
| SSBP3_HUMAN | [view interactions] | High throughput | no | no |
| KRA42_HUMAN | [view interactions] | High throughput | no | no |
| ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IKZF3_HUMAN | [view interactions] | High throughput | no | no |
| T22D4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KR106_HUMAN | [view interactions] | High throughput | no | no |
| PAX6_HUMAN | [view interactions] | High throughput | no | no |
| TNS2_HUMAN | [view interactions] | High throughput | no | no |
| SRCRL_HUMAN | [view interactions] | High throughput | no | yes |
| E2F4_HUMAN | [view interactions] | High throughput | no | no |
| FOXN1_HUMAN | [view interactions] | High throughput | no | no |
| GG6L9_HUMAN | [view interactions] | High throughput | no | no |
| GSK3B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NCF2_HUMAN | [view interactions] | Computational | no | no |
| KPCA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| UBXN7_HUMAN | [view interactions] | Computational | no | yes |
| CCNB1_HUMAN | [view interactions] | Computational | no | no |
| MK03_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MAX_HUMAN | [view interactions] | Computational | no | yes |
| 1433G_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NCF4_HUMAN | [view interactions] | Computational | no | no |
| KPCZ_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| 2A5A_HUMAN | [view interactions] | Computational | no | yes |
| 1433T_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CDK1_HUMAN | [view interactions] | Computational | no | no |
| NCF1_HUMAN | [view interactions] | Computational | no | no |
| MK01_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KPCD_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | Computational | yes | yes |