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KCND2_HUMAN

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Mediates the major part of the dendritic A-type current I(SA) in brain neurons . This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials from the neuronal cell body to the dendrites. Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity . Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5 . Mediates the transient outward current I(to) in rodent heart left ventricle apex cells, but not in human heart, where this current is mediated by another family member. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCND2 and KCND3; channel properties depend on the type of pore-forming alpha subunits that are part of the channel. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes. Interaction with specific isoforms of the regulatory subunits KCNIP1, KCNIP2, KCNIP3 or KCNIP4 strongly increases expression at the cell surface and thereby increases channel activity; it modulates the kinetics of channel activation and inactivation, shifts the threshold for channel activation to more negative voltage values, shifts the threshold for inactivation to less negative voltages and accelerates recovery after inactivation (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Likewise, interaction with DPP6 or DPP10 promotes expression at the cell membrane and regulates both channel characteristics and activity . [View more on UniProt]

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Position Amino acid Mutation Disease Overlap with binding region
404 Val Met - -

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in KCND2_HUMAN
GO:0005216 ion channel activity 33.3333 4 yes
GO:0005244 voltage-gated ion channel activity 33.3333 4 yes
GO:0005261 cation channel activity 33.3333 5 yes
GO:0008324 cation transmembrane transporter activity 33.3333 4 yes
GO:0015267 channel activity 33.3333 4 yes
GO:0022832 voltage-gated channel activity 33.3333 6 yes
GO:0022836 gated channel activity 33.3333 5 yes
GO:0022843 voltage-gated cation channel activity 33.3333 5 yes
GO:0022890 inorganic cation transmembrane transporter activity 33.3333 4 yes
GO:0046873 metal ion transmembrane transporter activity 33.3333 5 yes
GO:0019900 kinase binding 33.3333 4 no
GO:0005249 voltage-gated potassium channel activity 27.7778 6 yes
GO:0005267 potassium channel activity 27.7778 6 yes
GO:0015079 potassium ion transmembrane transporter activity 27.7778 6 yes
GO:0019901 protein kinase binding 27.7778 5 no
GO:0015459 potassium channel regulator activity 22.2222 4 no
GO:0001664 G protein-coupled receptor binding 22.2222 4 no
GO:0045296 cadherin binding 22.2222 4 no
GO:0015271 outward rectifier potassium channel activity 16.6667 7 yes
GO:0046872 metal ion binding 16.6667 4 yes
GO:0005250 A-type (transient outward) potassium channel activity 11.1111 8 yes
GO:1905030 voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential 11.1111 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in KCND2_HUMAN
GO:0051049 regulation of transport 66.6667 4 yes
GO:0034762 regulation of transmembrane transport 50.0000 4 yes
GO:0034765 regulation of ion transmembrane transport 50.0000 5 yes
GO:0043269 regulation of ion transport 50.0000 5 yes
GO:0008104 protein localization 50.0000 4 no
GO:0048522 positive regulation of cellular process 50.0000 4 no
GO:0022607 cellular component assembly 44.4444 4 yes
GO:0032880 regulation of protein localization 44.4444 5 no
GO:0048523 negative regulation of cellular process 44.4444 4 no
GO:0051128 regulation of cellular component organization 44.4444 4 no
GO:0060255 regulation of macromolecule metabolic process 44.4444 4 no
GO:0060341 regulation of cellular localization 44.4444 4 no
GO:0009893 positive regulation of metabolic process 38.8889 4 no
GO:0031323 regulation of cellular metabolic process 38.8889 4 no
GO:0051171 regulation of nitrogen compound metabolic process 38.8889 4 no
GO:0080090 regulation of primary metabolic process 38.8889 4 no
GO:0006996 organelle organization 33.3333 4 no
GO:0010468 regulation of gene expression 33.3333 5 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0010646 regulation of cell communication 33.3333 4 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0043933 protein-containing complex organization 27.7778 4 yes
GO:0072657 protein localization to membrane 27.7778 4 no
GO:1904062 regulation of cation transmembrane transport 27.7778 6 no
GO:1990778 protein localization to cell periphery 27.7778 5 no
GO:0006355 regulation of DNA-templated transcription 27.7778 6 no
GO:0009889 regulation of biosynthetic process 27.7778 4 no
GO:0009892 negative regulation of metabolic process 27.7778 4 no
GO:0009966 regulation of signal transduction 27.7778 4 no
GO:0010556 regulation of macromolecule biosynthetic process 27.7778 5 no
GO:0010605 negative regulation of macromolecule metabolic process 27.7778 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 27.7778 5 no
GO:0031324 negative regulation of cellular metabolic process 27.7778 5 no
GO:0031326 regulation of cellular biosynthetic process 27.7778 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 27.7778 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 27.7778 5 no
GO:0051246 regulation of protein metabolic process 27.7778 5 no
GO:0051252 regulation of RNA metabolic process 27.7778 5 no
GO:1903506 regulation of nucleic acid-templated transcription 27.7778 7 no
GO:2001141 regulation of RNA biosynthetic process 27.7778 6 no
GO:1903829 positive regulation of protein localization 27.7778 5 no
GO:0044087 regulation of cellular component biogenesis 27.7778 4 no
GO:0071310 cellular response to organic substance 27.7778 4 no
GO:0006811 ion transport 22.2222 4 yes
GO:0006812 cation transport 22.2222 5 yes
GO:0006813 potassium ion transport 22.2222 7 yes
GO:0007268 chemical synaptic transmission 22.2222 6 yes
GO:0030001 metal ion transport 22.2222 6 yes
GO:0036293 response to decreased oxygen levels 22.2222 4 yes
GO:0065003 protein-containing complex assembly 22.2222 5 yes
GO:0071805 potassium ion transmembrane transport 22.2222 6 yes
GO:0098655 cation transmembrane transport 22.2222 4 yes
GO:0098660 inorganic ion transmembrane transport 22.2222 4 yes
GO:0098662 inorganic cation transmembrane transport 22.2222 5 yes
GO:0098916 anterograde trans-synaptic signaling 22.2222 5 yes
GO:0099537 trans-synaptic signaling 22.2222 4 yes
GO:0010959 regulation of metal ion transport 22.2222 6 no
GO:0043266 regulation of potassium ion transport 22.2222 7 no
GO:0072659 protein localization to plasma membrane 22.2222 5 no
GO:1901379 regulation of potassium ion transmembrane transport 22.2222 7 no
GO:0007010 cytoskeleton organization 22.2222 5 no
GO:0009894 regulation of catabolic process 22.2222 4 no
GO:0010648 negative regulation of cell communication 22.2222 5 no
GO:0023057 negative regulation of signaling 22.2222 4 no
GO:0031399 regulation of protein modification process 22.2222 6 no
GO:0031401 positive regulation of protein modification process 22.2222 7 no
GO:0033043 regulation of organelle organization 22.2222 5 no
GO:0034330 cell junction organization 22.2222 4 no
GO:0043085 positive regulation of catalytic activity 22.2222 4 no
GO:0048584 positive regulation of response to stimulus 22.2222 4 no
GO:0051247 positive regulation of protein metabolic process 22.2222 6 no
GO:0051338 regulation of transferase activity 22.2222 4 no
GO:0051347 positive regulation of transferase activity 22.2222 5 no
GO:0051130 positive regulation of cellular component organization 22.2222 5 no
GO:0009890 negative regulation of biosynthetic process 22.2222 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 22.2222 6 no
GO:0031327 negative regulation of cellular biosynthetic process 22.2222 6 no
GO:0045892 negative regulation of DNA-templated transcription 22.2222 7 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 22.2222 6 no
GO:0051050 positive regulation of transport 22.2222 4 no
GO:0051223 regulation of protein transport 22.2222 5 no
GO:0051253 negative regulation of RNA metabolic process 22.2222 6 no
GO:0070201 regulation of establishment of protein localization 22.2222 6 no
GO:1902679 negative regulation of RNA biosynthetic process 22.2222 7 no
GO:1902903 regulation of supramolecular fiber organization 22.2222 5 no
GO:1903507 negative regulation of nucleic acid-templated transcription 22.2222 8 no
GO:0001508 action potential 16.6667 4 yes
GO:0036294 cellular response to decreased oxygen levels 16.6667 5 yes
GO:0051259 protein complex oligomerization 16.6667 6 yes
GO:0051260 protein homooligomerization 16.6667 7 yes
GO:0071453 cellular response to oxygen levels 16.6667 4 yes
GO:0071456 cellular response to hypoxia 16.6667 4 yes
GO:0007600 sensory perception 11.1111 4 yes
GO:0019228 neuronal action potential 11.1111 5 yes
GO:0019233 sensory perception of pain 11.1111 5 yes
GO:0045475 locomotor rhythm 11.1111 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in KCND2_HUMAN
DOID:114 heart disease 16.6667 3 no
DOID:0050700 cardiomyopathy 11.1111 4 no
DOID:0060036 intrinsic cardiomyopathy 11.1111 5 no
DOID:0080000 muscular disease 11.1111 3 no
DOID:423 myopathy 11.1111 5 no
DOID:66 muscle tissue disease 11.1111 4 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KIF17_HUMAN [view interactions] Low throughput no no
KCIP1_HUMAN [view interactions] Low throughput no yes
KCIP2_HUMAN [view interactions] Low throughput no no
FLNC_HUMAN [view entry] [view interactions] Low throughput yes no
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
NCS1_HUMAN [view entry] [view interactions] Low throughput yes yes
KCIP4_HUMAN [view interactions] Low throughput no no
KCNE4_HUMAN [view interactions] Low throughput no no
FLNA_HUMAN [view entry] [view interactions] Low throughput yes no
DPP10_HUMAN [view interactions] Low throughput no yes
DPP6_HUMAN [view entry] [view interactions] Low throughput yes no
CSEN_HUMAN [view interactions] Low throughput no no
TLR3_HUMAN [view interactions] Low throughput no yes
KCNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
PIN1_HUMAN [view entry] [view interactions] Low throughput yes yes
KCND2_HUMAN [view entry] [view interactions] Low throughput yes yes
KCTD5_HUMAN [view interactions] High throughput no no
GBB4_HUMAN [view entry] [view interactions] High throughput yes yes
KCTD2_HUMAN [view interactions] High throughput no no
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
TBA1C_HUMAN [view interactions] High throughput no yes
IL16_HUMAN [view interactions] High throughput no no
RARA_HUMAN [view interactions] High throughput no no
KCD17_HUMAN [view interactions] High throughput no yes
BAG1_HUMAN [view interactions] High throughput no yes
CHIP_HUMAN [view entry] [view interactions] High throughput yes yes
NBEA_HUMAN [view entry] [view interactions] High throughput yes yes
CAV3_HUMAN [view interactions] Computational no no
KCNE2_HUMAN [view interactions] Computational no no
DLG1_HUMAN [view entry] [view interactions] Computational yes yes
KCAB2_HUMAN [view entry] [view interactions] Computational yes yes
KCAB1_HUMAN [view interactions] Computational no no
KCNH5_HUMAN [view interactions] Computational no no
KCNH2_HUMAN [view interactions] Computational no no
KCNH1_HUMAN [view entry] [view interactions] Computational yes yes
KCAB3_HUMAN [view interactions] Computational no no