KCND2_HUMAN
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Mediates the major part of the dendritic A-type current I(SA) in brain neurons . This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials from the neuronal cell body to the dendrites. Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity . Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5 . Mediates the transient outward current I(to) in rodent heart left ventricle apex cells, but not in human heart, where this current is mediated by another family member. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCND2 and KCND3; channel properties depend on the type of pore-forming alpha subunits that are part of the channel. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes. Interaction with specific isoforms of the regulatory subunits KCNIP1, KCNIP2, KCNIP3 or KCNIP4 strongly increases expression at the cell surface and thereby increases channel activity; it modulates the kinetics of channel activation and inactivation, shifts the threshold for channel activation to more negative voltage values, shifts the threshold for inactivation to less negative voltages and accelerates recovery after inactivation (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Likewise, interaction with DPP6 or DPP10 promotes expression at the cell membrane and regulates both channel characteristics and activity . [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Position | Amino acid | Mutation | Disease | Overlap with binding region |
---|---|---|---|---|
404 | Val | Met | - | - |
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in KCND2_HUMAN |
---|---|---|---|---|
GO:0005216 | ion channel activity | 33.3333 | 4 | yes |
GO:0005244 | voltage-gated ion channel activity | 33.3333 | 4 | yes |
GO:0005261 | cation channel activity | 33.3333 | 5 | yes |
GO:0008324 | cation transmembrane transporter activity | 33.3333 | 4 | yes |
GO:0015267 | channel activity | 33.3333 | 4 | yes |
GO:0022832 | voltage-gated channel activity | 33.3333 | 6 | yes |
GO:0022836 | gated channel activity | 33.3333 | 5 | yes |
GO:0022843 | voltage-gated cation channel activity | 33.3333 | 5 | yes |
GO:0022890 | inorganic cation transmembrane transporter activity | 33.3333 | 4 | yes |
GO:0046873 | metal ion transmembrane transporter activity | 33.3333 | 5 | yes |
GO:0019900 | kinase binding | 33.3333 | 4 | no |
GO:0005249 | voltage-gated potassium channel activity | 27.7778 | 6 | yes |
GO:0005267 | potassium channel activity | 27.7778 | 6 | yes |
GO:0015079 | potassium ion transmembrane transporter activity | 27.7778 | 6 | yes |
GO:0019901 | protein kinase binding | 27.7778 | 5 | no |
GO:0015459 | potassium channel regulator activity | 22.2222 | 4 | no |
GO:0001664 | G protein-coupled receptor binding | 22.2222 | 4 | no |
GO:0045296 | cadherin binding | 22.2222 | 4 | no |
GO:0015271 | outward rectifier potassium channel activity | 16.6667 | 7 | yes |
GO:0046872 | metal ion binding | 16.6667 | 4 | yes |
GO:0005250 | A-type (transient outward) potassium channel activity | 11.1111 | 8 | yes |
GO:1905030 | voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential | 11.1111 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in KCND2_HUMAN |
---|---|---|---|---|
GO:0051049 | regulation of transport | 66.6667 | 4 | yes |
GO:0034762 | regulation of transmembrane transport | 50.0000 | 4 | yes |
GO:0034765 | regulation of ion transmembrane transport | 50.0000 | 5 | yes |
GO:0043269 | regulation of ion transport | 50.0000 | 5 | yes |
GO:0008104 | protein localization | 50.0000 | 4 | no |
GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
GO:0022607 | cellular component assembly | 44.4444 | 4 | yes |
GO:0032880 | regulation of protein localization | 44.4444 | 5 | no |
GO:0048523 | negative regulation of cellular process | 44.4444 | 4 | no |
GO:0051128 | regulation of cellular component organization | 44.4444 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 44.4444 | 4 | no |
GO:0060341 | regulation of cellular localization | 44.4444 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 38.8889 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 38.8889 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 38.8889 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 38.8889 | 4 | no |
GO:0006996 | organelle organization | 33.3333 | 4 | no |
GO:0010468 | regulation of gene expression | 33.3333 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
GO:0010646 | regulation of cell communication | 33.3333 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 33.3333 | 5 | no |
GO:0043933 | protein-containing complex organization | 27.7778 | 4 | yes |
GO:0072657 | protein localization to membrane | 27.7778 | 4 | no |
GO:1904062 | regulation of cation transmembrane transport | 27.7778 | 6 | no |
GO:1990778 | protein localization to cell periphery | 27.7778 | 5 | no |
GO:0006355 | regulation of DNA-templated transcription | 27.7778 | 6 | no |
GO:0009889 | regulation of biosynthetic process | 27.7778 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 27.7778 | 4 | no |
GO:0009966 | regulation of signal transduction | 27.7778 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 27.7778 | 5 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 27.7778 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 27.7778 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 27.7778 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 27.7778 | 5 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 27.7778 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 27.7778 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 27.7778 | 5 | no |
GO:0051252 | regulation of RNA metabolic process | 27.7778 | 5 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 27.7778 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 27.7778 | 6 | no |
GO:1903829 | positive regulation of protein localization | 27.7778 | 5 | no |
GO:0044087 | regulation of cellular component biogenesis | 27.7778 | 4 | no |
GO:0071310 | cellular response to organic substance | 27.7778 | 4 | no |
GO:0006811 | ion transport | 22.2222 | 4 | yes |
GO:0006812 | cation transport | 22.2222 | 5 | yes |
GO:0006813 | potassium ion transport | 22.2222 | 7 | yes |
GO:0007268 | chemical synaptic transmission | 22.2222 | 6 | yes |
GO:0030001 | metal ion transport | 22.2222 | 6 | yes |
GO:0036293 | response to decreased oxygen levels | 22.2222 | 4 | yes |
GO:0065003 | protein-containing complex assembly | 22.2222 | 5 | yes |
GO:0071805 | potassium ion transmembrane transport | 22.2222 | 6 | yes |
GO:0098655 | cation transmembrane transport | 22.2222 | 4 | yes |
GO:0098660 | inorganic ion transmembrane transport | 22.2222 | 4 | yes |
GO:0098662 | inorganic cation transmembrane transport | 22.2222 | 5 | yes |
GO:0098916 | anterograde trans-synaptic signaling | 22.2222 | 5 | yes |
GO:0099537 | trans-synaptic signaling | 22.2222 | 4 | yes |
GO:0010959 | regulation of metal ion transport | 22.2222 | 6 | no |
GO:0043266 | regulation of potassium ion transport | 22.2222 | 7 | no |
GO:0072659 | protein localization to plasma membrane | 22.2222 | 5 | no |
GO:1901379 | regulation of potassium ion transmembrane transport | 22.2222 | 7 | no |
GO:0007010 | cytoskeleton organization | 22.2222 | 5 | no |
GO:0009894 | regulation of catabolic process | 22.2222 | 4 | no |
GO:0010648 | negative regulation of cell communication | 22.2222 | 5 | no |
GO:0023057 | negative regulation of signaling | 22.2222 | 4 | no |
GO:0031399 | regulation of protein modification process | 22.2222 | 6 | no |
GO:0031401 | positive regulation of protein modification process | 22.2222 | 7 | no |
GO:0033043 | regulation of organelle organization | 22.2222 | 5 | no |
GO:0034330 | cell junction organization | 22.2222 | 4 | no |
GO:0043085 | positive regulation of catalytic activity | 22.2222 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 22.2222 | 4 | no |
GO:0051247 | positive regulation of protein metabolic process | 22.2222 | 6 | no |
GO:0051338 | regulation of transferase activity | 22.2222 | 4 | no |
GO:0051347 | positive regulation of transferase activity | 22.2222 | 5 | no |
GO:0051130 | positive regulation of cellular component organization | 22.2222 | 5 | no |
GO:0009890 | negative regulation of biosynthetic process | 22.2222 | 5 | no |
GO:0010558 | negative regulation of macromolecule biosynthetic process | 22.2222 | 6 | no |
GO:0031327 | negative regulation of cellular biosynthetic process | 22.2222 | 6 | no |
GO:0045892 | negative regulation of DNA-templated transcription | 22.2222 | 7 | no |
GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 22.2222 | 6 | no |
GO:0051050 | positive regulation of transport | 22.2222 | 4 | no |
GO:0051223 | regulation of protein transport | 22.2222 | 5 | no |
GO:0051253 | negative regulation of RNA metabolic process | 22.2222 | 6 | no |
GO:0070201 | regulation of establishment of protein localization | 22.2222 | 6 | no |
GO:1902679 | negative regulation of RNA biosynthetic process | 22.2222 | 7 | no |
GO:1902903 | regulation of supramolecular fiber organization | 22.2222 | 5 | no |
GO:1903507 | negative regulation of nucleic acid-templated transcription | 22.2222 | 8 | no |
GO:0001508 | action potential | 16.6667 | 4 | yes |
GO:0036294 | cellular response to decreased oxygen levels | 16.6667 | 5 | yes |
GO:0051259 | protein complex oligomerization | 16.6667 | 6 | yes |
GO:0051260 | protein homooligomerization | 16.6667 | 7 | yes |
GO:0071453 | cellular response to oxygen levels | 16.6667 | 4 | yes |
GO:0071456 | cellular response to hypoxia | 16.6667 | 4 | yes |
GO:0007600 | sensory perception | 11.1111 | 4 | yes |
GO:0019228 | neuronal action potential | 11.1111 | 5 | yes |
GO:0019233 | sensory perception of pain | 11.1111 | 5 | yes |
GO:0045475 | locomotor rhythm | 11.1111 | 4 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in KCND2_HUMAN |
---|---|---|---|---|
DOID:114 | heart disease | 16.6667 | 3 | no |
DOID:0050700 | cardiomyopathy | 11.1111 | 4 | no |
DOID:0060036 | intrinsic cardiomyopathy | 11.1111 | 5 | no |
DOID:0080000 | muscular disease | 11.1111 | 3 | no |
DOID:423 | myopathy | 11.1111 | 5 | no |
DOID:66 | muscle tissue disease | 11.1111 | 4 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
KIF17_HUMAN | [view interactions] | Low throughput | no | no |
KCIP1_HUMAN | [view interactions] | Low throughput | no | yes |
KCIP2_HUMAN | [view interactions] | Low throughput | no | no |
FLNC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NCS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KCIP4_HUMAN | [view interactions] | Low throughput | no | no |
KCNE4_HUMAN | [view interactions] | Low throughput | no | no |
FLNA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
DPP10_HUMAN | [view interactions] | Low throughput | no | yes |
DPP6_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
CSEN_HUMAN | [view interactions] | Low throughput | no | no |
TLR3_HUMAN | [view interactions] | Low throughput | no | yes |
KCNB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PIN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KCND2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KCTD5_HUMAN | [view interactions] | High throughput | no | no |
GBB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KCTD2_HUMAN | [view interactions] | High throughput | no | no |
HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBA1C_HUMAN | [view interactions] | High throughput | no | yes |
IL16_HUMAN | [view interactions] | High throughput | no | no |
RARA_HUMAN | [view interactions] | High throughput | no | no |
KCD17_HUMAN | [view interactions] | High throughput | no | yes |
BAG1_HUMAN | [view interactions] | High throughput | no | yes |
CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NBEA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAV3_HUMAN | [view interactions] | Computational | no | no |
KCNE2_HUMAN | [view interactions] | Computational | no | no |
DLG1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
KCAB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
KCAB1_HUMAN | [view interactions] | Computational | no | no |
KCNH5_HUMAN | [view interactions] | Computational | no | no |
KCNH2_HUMAN | [view interactions] | Computational | no | no |
KCNH1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
KCAB3_HUMAN | [view interactions] | Computational | no | no |