AP2A1_HUMAN
Evidence for PS localization
Functions
Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed). The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AP2A1_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 24.4094 | 4 | yes |
| GO:0046872 | metal ion binding | 24.4094 | 4 | no |
| GO:0019901 | protein kinase binding | 22.8346 | 5 | yes |
| GO:0017076 | purine nucleotide binding | 22.0472 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 22.0472 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 22.0472 | 4 | no |
| GO:0003779 | actin binding | 20.4724 | 4 | no |
| GO:0035615 | clathrin adaptor activity | 5.5118 | 4 | yes |
| GO:0050750 | low-density lipoprotein particle receptor binding | 3.1496 | 5 | yes |
| GO:0070325 | lipoprotein particle receptor binding | 3.1496 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AP2A1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 61.4173 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 52.7559 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 51.9685 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 43.3071 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 43.3071 | 4 | no |
| GO:0008104 | protein localization | 42.5197 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 40.9449 | 4 | yes |
| GO:0010646 | regulation of cell communication | 40.9449 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 40.1575 | 4 | yes |
| GO:0006897 | endocytosis | 39.3701 | 5 | yes |
| GO:0006996 | organelle organization | 38.5827 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 37.0079 | 4 | no |
| GO:0051049 | regulation of transport | 37.0079 | 4 | no |
| GO:0022607 | cellular component assembly | 34.6457 | 4 | no |
| GO:0071702 | organic substance transport | 33.0709 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 33.0709 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 31.4961 | 4 | no |
| GO:0071705 | nitrogen compound transport | 30.7087 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 29.9213 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 29.9213 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 29.1339 | 5 | no |
| GO:0015031 | protein transport | 28.3465 | 4 | yes |
| GO:0010468 | regulation of gene expression | 28.3465 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 27.5591 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 25.1969 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 24.4094 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 24.4094 | 4 | no |
| GO:0051050 | positive regulation of transport | 24.4094 | 4 | no |
| GO:0060341 | regulation of cellular localization | 24.4094 | 4 | no |
| GO:0033043 | regulation of organelle organization | 24.4094 | 5 | no |
| GO:0006898 | receptor-mediated endocytosis | 23.6220 | 6 | yes |
| GO:0009889 | regulation of biosynthetic process | 23.6220 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 23.6220 | 5 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 23.6220 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 23.6220 | 5 | no |
| GO:0023056 | positive regulation of signaling | 23.6220 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 23.6220 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 22.8346 | 4 | yes |
| GO:0030030 | cell projection organization | 22.8346 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 22.8346 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.0472 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 22.0472 | 5 | no |
| GO:0032880 | regulation of protein localization | 22.0472 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.0472 | 6 | no |
| GO:0006886 | intracellular protein transport | 21.2598 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.2598 | 5 | yes |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 21.2598 | 5 | yes |
| GO:0043933 | protein-containing complex organization | 21.2598 | 4 | no |
| GO:0007010 | cytoskeleton organization | 21.2598 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 20.4724 | 5 | no |
| GO:0036211 | protein modification process | 20.4724 | 4 | no |
| GO:0043412 | macromolecule modification | 20.4724 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 20.4724 | 5 | no |
| GO:0010941 | regulation of cell death | 20.4724 | 4 | no |
| GO:0072583 | clathrin-dependent endocytosis | 12.5984 | 7 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 11.0236 | 5 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 11.0236 | 6 | yes |
| GO:0048193 | Golgi vesicle transport | 7.0866 | 5 | yes |
| GO:0006892 | post-Golgi vesicle-mediated transport | 5.5118 | 6 | yes |
| GO:0016482 | cytosolic transport | 5.5118 | 4 | yes |
| GO:0006109 | regulation of carbohydrate metabolic process | 3.1496 | 5 | yes |
| GO:0043255 | regulation of carbohydrate biosynthetic process | 3.1496 | 5 | yes |
| GO:0032881 | regulation of polysaccharide metabolic process | 2.3622 | 5 | yes |
| GO:0032885 | regulation of polysaccharide biosynthetic process | 2.3622 | 6 | yes |
| GO:0006895 | Golgi to endosome transport | 1.5748 | 5 | yes |
| GO:0045912 | negative regulation of carbohydrate metabolic process | 1.5748 | 5 | yes |
| GO:1900125 | regulation of hyaluronan biosynthetic process | 1.5748 | 5 | yes |
| GO:1900126 | negative regulation of hyaluronan biosynthetic process | 1.5748 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in AP2A1_HUMAN |
|---|---|---|---|---|
| DOID:0060038 | specific developmental disorder | 1.5748 | 3 | no |
| DOID:1059 | intellectual disability | 1.5748 | 4 | no |
| DOID:114 | heart disease | 1.5748 | 3 | no |
| DOID:331 | central nervous system disease | 1.5748 | 3 | no |
| DOID:936 | brain disease | 1.5748 | 4 | no |
| DOID:0050155 | sensory system disease | 1.5748 | 3 | no |
| DOID:0050563 | nonsyndromic deafness | 1.5748 | 5 | no |
| DOID:0050564 | autosomal dominant nonsyndromic deafness | 1.5748 | 6 | no |
| DOID:2742 | auditory system disease | 1.5748 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| EHD1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NAGPA_HUMAN | [view interactions] | Low throughput | no | no |
| SYNJ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BIN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NUMB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RBP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ITSN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ATG9A_HUMAN | [view interactions] | Low throughput | no | yes |
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| NMDE2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PI51C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FCHO2_HUMAN | [view interactions] | Low throughput | no | yes |
| SGIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP2S1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EPS15_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DPYL2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| L1CAM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CD22_HUMAN | [view interactions] | Low throughput | no | no |
| RFIP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AMPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BRCA1_HUMAN | [view interactions] | Low throughput | no | yes |
| REPS2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EPN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MYO6_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ARRB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ABCBB_HUMAN | [view interactions] | Low throughput | no | no |
| AAGAB_HUMAN | [view interactions] | Low throughput | no | yes |
| EPN4_HUMAN | [view interactions] | Low throughput | no | yes |
| ARF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| K1107_HUMAN | [view interactions] | Low throughput | no | yes |
| DVL2_HUMAN | [view interactions] | Low throughput | no | yes |
| ZCH10_HUMAN | [view interactions] | High throughput | no | yes |
| INSY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MEA1_HUMAN | [view interactions] | High throughput | no | no |
| ZBTB3_HUMAN | [view interactions] | High throughput | no | yes |
| EP15R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| BRD3_HUMAN | [view interactions] | High throughput | no | yes |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ROA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NECP1_HUMAN | [view interactions] | High throughput | no | no |
| SF3B1_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| PIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTF2_HUMAN | [view interactions] | High throughput | no | yes |
| EI2BA_HUMAN | [view interactions] | High throughput | no | yes |
| SYT3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DYN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PACS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNP29_HUMAN | [view interactions] | High throughput | no | yes |
| SYT7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| MIB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPEB4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTIF_HUMAN | [view interactions] | High throughput | no | yes |
| MEX3B_HUMAN | [view interactions] | High throughput | no | no |
| PATL1_HUMAN | [view interactions] | High throughput | no | yes |
| SMAP2_HUMAN | [view interactions] | High throughput | no | yes |
| TNR6A_HUMAN | [view interactions] | High throughput | no | yes |
| TNR6B_HUMAN | [view interactions] | High throughput | no | yes |
| TNR6C_HUMAN | [view interactions] | High throughput | no | no |
| DDX3X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EST1A_HUMAN | [view interactions] | High throughput | no | yes |
| SMAD9_HUMAN | [view interactions] | High throughput | no | yes |
| SMG7_HUMAN | [view interactions] | High throughput | no | no |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DERL1_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| PP6R3_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| AAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOLM1_HUMAN | [view interactions] | High throughput | no | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| SHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFR1_HUMAN | [view interactions] | High throughput | no | yes |
| FURIN_HUMAN | [view interactions] | High throughput | no | yes |
| BCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| CUL4B_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| LYRIC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| SPS2L_HUMAN | [view interactions] | High throughput | no | yes |
| H2B2C_HUMAN | [view interactions] | High throughput | no | no |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| DAB2_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUX4_HUMAN | [view interactions] | High throughput | no | no |
| EFNB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| MED4_HUMAN | [view interactions] | High throughput | no | yes |
| MED23_HUMAN | [view interactions] | High throughput | no | no |
| M3K9_HUMAN | [view interactions] | High throughput | no | yes |
| WNK3_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| RNPS1_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF6_HUMAN | [view interactions] | High throughput | no | yes |
| SNP25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCKP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEX5R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LITD1_HUMAN | [view interactions] | High throughput | no | no |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| TBCD5_HUMAN | [view interactions] | High throughput | no | yes |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| TOE1_HUMAN | [view interactions] | High throughput | no | yes |
| KC1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EDC4_HUMAN | [view interactions] | High throughput | no | yes |
| CRK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB32_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| CE128_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
| TANK_HUMAN | [view interactions] | High throughput | no | yes |
| SHBG_HUMAN | [view interactions] | High throughput | no | no |
| SH3K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRK5_HUMAN | [view interactions] | High throughput | no | yes |
| ABL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| RARA_HUMAN | [view interactions] | High throughput | no | no |
| MMS19_HUMAN | [view interactions] | High throughput | no | yes |
| RNF11_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA2_HUMAN | [view interactions] | High throughput | no | no |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| S2541_HUMAN | [view interactions] | High throughput | no | no |
| NECP2_HUMAN | [view interactions] | High throughput | no | yes |
| LRFN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBT46_HUMAN | [view interactions] | High throughput | no | no |
| SPC25_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PDLI7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SC16A_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GTSE1_HUMAN | [view interactions] | High throughput | no | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| MYO5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| ARX_HUMAN | [view interactions] | High throughput | no | no |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFA97_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CD2AP_HUMAN | [view interactions] | High throughput | no | no |
| MCM3_HUMAN | [view interactions] | High throughput | no | no |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| USO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLNB_HUMAN | [view interactions] | High throughput | no | no |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| MEX3C_HUMAN | [view interactions] | High throughput | no | yes |
| UTP25_HUMAN | [view interactions] | High throughput | no | yes |
| ZN746_HUMAN | [view interactions] | High throughput | no | no |
| ARFG1_HUMAN | [view interactions] | High throughput | no | no |
| SNX9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUN3A_HUMAN | [view interactions] | High throughput | no | yes |
| GP156_HUMAN | [view interactions] | High throughput | no | no |
| GPBL1_HUMAN | [view interactions] | High throughput | no | yes |
| FCHO1_HUMAN | [view interactions] | High throughput | no | yes |
| PICAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INT4_HUMAN | [view interactions] | High throughput | no | yes |
| SOST_HUMAN | [view interactions] | High throughput | no | no |
| STABP_HUMAN | [view interactions] | High throughput | no | yes |
| REPS1_HUMAN | [view interactions] | High throughput | no | yes |
| PP6R2_HUMAN | [view interactions] | High throughput | no | no |
| LSR_HUMAN | [view interactions] | High throughput | no | yes |
| NKAP1_HUMAN | [view interactions] | High throughput | no | yes |
| CXB7_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| LNX1_HUMAN | [view interactions] | High throughput | no | yes |
| BMR1A_HUMAN | [view interactions] | High throughput | no | no |
| DX39B_HUMAN | [view interactions] | High throughput | no | no |
| DIM1_HUMAN | [view interactions] | High throughput | no | yes |
| QCR7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| ARI1_HUMAN | [view interactions] | High throughput | no | yes |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| AGO2_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| DCPS_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TXNIP_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA2_HUMAN | [view interactions] | High throughput | no | no |
| RC3H1_HUMAN | [view interactions] | High throughput | no | yes |
| RC3H2_HUMAN | [view interactions] | High throughput | no | yes |
| KCD15_HUMAN | [view interactions] | High throughput | no | no |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| TF3B_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CC14A_HUMAN | [view interactions] | High throughput | no | yes |
| AUXI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTMR4_HUMAN | [view interactions] | High throughput | no | no |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| BRD7_HUMAN | [view interactions] | High throughput | no | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| SHC2_HUMAN | [view interactions] | High throughput | no | yes |
| CCD32_HUMAN | [view interactions] | High throughput | no | yes |
| AP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP3M2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| EPN2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CLH2_HUMAN | [view interactions] | Computational | no | no |
| TSKS_HUMAN | [view interactions] | Computational | no | no |
| AP5B1_HUMAN | [view interactions] | Computational | no | yes |
| FZD2_HUMAN | [view interactions] | Computational | no | no |
| AP5M1_HUMAN | [view interactions] | Computational | no | no |
| ROR1_HUMAN | [view interactions] | Computational | no | no |
| DNAL4_HUMAN | [view interactions] | Computational | no | yes |
| AP4B1_HUMAN | [view interactions] | Computational | no | yes |
| AP1G1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CCL11_HUMAN | [view interactions] | Computational | no | no |
| EHD2_HUMAN | [view interactions] | Computational | no | no |
| AP5S1_HUMAN | [view interactions] | Computational | no | yes |
| PICK1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NCALD_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| FZD5_HUMAN | [view interactions] | Computational | no | yes |
| PP2BA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| THRB_HUMAN | [view interactions] | Computational | no | no |
| KCNQ5_HUMAN | [view interactions] | Computational | no | yes |
| ITSN2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP3S1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CCL4_HUMAN | [view interactions] | Computational | no | no |
| DYN2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SDF1_HUMAN | [view interactions] | Computational | no | no |
| GRIA4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GRIA2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GRIP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| EDN1_HUMAN | [view interactions] | Computational | no | no |
| PP2BC_HUMAN | [view interactions] | Computational | no | yes |
| PP2BB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP4M1_HUMAN | [view interactions] | Computational | no | yes |
| AP4E1_HUMAN | [view interactions] | Computational | no | no |
| KPCA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP3S2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| AP1S1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SYNRG_HUMAN | [view interactions] | Computational | no | yes |
| SYNJ2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KPCG_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CD4_HUMAN | [view interactions] | Computational | no | no |
| GRIA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| EPN3_HUMAN | [view interactions] | Computational | no | no |
| AFTIN_HUMAN | [view interactions] | Computational | no | yes |
| GRIA3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ROR2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ANGT_HUMAN | [view interactions] | Computational | no | no |