AP2A1_HUMAN
Evidence for PS localization
Functions
Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed). The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AP2A1_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 27.5591 | 4 | yes |
| GO:0043168 | anion binding | 26.7717 | 4 | no |
| GO:0043169 | cation binding | 26.7717 | 4 | no |
| GO:0046872 | metal ion binding | 25.9843 | 5 | no |
| GO:0019901 | protein kinase binding | 25.1969 | 5 | yes |
| GO:0000166 | nucleotide binding | 24.4094 | 4 | no |
| GO:0017076 | purine nucleotide binding | 24.4094 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 22.8346 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 22.0472 | 6 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 22.0472 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 20.4724 | 5 | no |
| GO:0003723 | RNA binding | 20.4724 | 4 | no |
| GO:0035615 | clathrin adaptor activity | 3.9370 | 4 | yes |
| GO:0050750 | low-density lipoprotein particle receptor binding | 3.1496 | 5 | yes |
| GO:0070325 | lipoprotein particle receptor binding | 3.1496 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AP2A1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 63.7795 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 56.6929 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 48.8189 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 46.4567 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 44.8819 | 4 | yes |
| GO:0022607 | cellular component assembly | 44.8819 | 4 | no |
| GO:0008104 | protein localization | 43.3071 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 43.3071 | 4 | yes |
| GO:0006996 | organelle organization | 42.5197 | 4 | no |
| GO:0010646 | regulation of cell communication | 42.5197 | 4 | no |
| GO:0098657 | import into cell | 40.1575 | 4 | yes |
| GO:0051049 | regulation of transport | 37.7953 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 37.7953 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 36.2205 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 36.2205 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 36.2205 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 34.6457 | 4 | no |
| GO:0010468 | regulation of gene expression | 34.6457 | 6 | no |
| GO:0051246 | regulation of protein metabolic process | 33.8583 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.0709 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 30.7087 | 4 | no |
| GO:0060341 | regulation of cellular localization | 30.7087 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 29.9213 | 5 | yes |
| GO:0043933 | protein-containing complex organization | 29.9213 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 28.3465 | 4 | yes |
| GO:0071702 | organic substance transport | 28.3465 | 4 | yes |
| GO:0023056 | positive regulation of signaling | 28.3465 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 28.3465 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 27.5591 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 27.5591 | 5 | no |
| GO:0032880 | regulation of protein localization | 27.5591 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.7717 | 5 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 26.7717 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.9843 | 5 | yes |
| GO:0071705 | nitrogen compound transport | 25.9843 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 25.1969 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.1969 | 5 | no |
| GO:0033043 | regulation of organelle organization | 25.1969 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 25.1969 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 24.4094 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 24.4094 | 7 | no |
| GO:0065003 | protein-containing complex assembly | 24.4094 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 24.4094 | 6 | no |
| GO:0051050 | positive regulation of transport | 23.6220 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 23.6220 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 23.6220 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 22.8346 | 5 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 22.8346 | 6 | yes |
| GO:0015031 | protein transport | 22.8346 | 4 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 22.8346 | 6 | yes |
| GO:0031399 | regulation of protein modification process | 22.8346 | 6 | no |
| GO:0036211 | protein modification process | 22.8346 | 4 | no |
| GO:0043412 | macromolecule modification | 22.8346 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.0472 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.0472 | 5 | no |
| GO:0006898 | receptor-mediated endocytosis | 21.2598 | 4 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 21.2598 | 4 | no |
| GO:0030030 | cell projection organization | 21.2598 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 21.2598 | 7 | no |
| GO:0051094 | positive regulation of developmental process | 21.2598 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 20.4724 | 7 | no |
| GO:0007010 | cytoskeleton organization | 20.4724 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 20.4724 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 19.6850 | 5 | yes |
| GO:0030100 | regulation of endocytosis | 18.8976 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 18.8976 | 6 | yes |
| GO:0006886 | intracellular protein transport | 14.9606 | 4 | yes |
| GO:0010975 | regulation of neuron projection development | 12.5984 | 7 | yes |
| GO:0031623 | receptor internalization | 12.5984 | 5 | yes |
| GO:0072583 | clathrin-dependent endocytosis | 11.8110 | 5 | yes |
| GO:0031346 | positive regulation of cell projection organization | 11.0236 | 6 | yes |
| GO:0048259 | regulation of receptor-mediated endocytosis | 9.4488 | 6 | yes |
| GO:0045807 | positive regulation of endocytosis | 8.6614 | 5 | yes |
| GO:0010976 | positive regulation of neuron projection development | 6.2992 | 7 | yes |
| GO:0016482 | cytosolic transport | 4.7244 | 4 | yes |
| GO:0048260 | positive regulation of receptor-mediated endocytosis | 4.7244 | 6 | yes |
| GO:0098884 | postsynaptic neurotransmitter receptor internalization | 4.7244 | 4 | yes |
| GO:0140239 | postsynaptic endocytosis | 4.7244 | 4 | yes |
| GO:0006109 | regulation of carbohydrate metabolic process | 3.9370 | 5 | yes |
| GO:0006892 | post-Golgi vesicle-mediated transport | 3.1496 | 4 | yes |
| GO:0043255 | regulation of carbohydrate biosynthetic process | 2.3622 | 5 | yes |
| GO:0045912 | negative regulation of carbohydrate metabolic process | 2.3622 | 5 | yes |
| GO:0006895 | Golgi to endosome transport | 1.5748 | 5 | yes |
| GO:0032881 | regulation of polysaccharide metabolic process | 1.5748 | 5 | yes |
| GO:0032885 | regulation of polysaccharide biosynthetic process | 1.5748 | 6 | yes |
| GO:1900125 | regulation of hyaluronan biosynthetic process | 1.5748 | 7 | yes |
| GO:1900126 | negative regulation of hyaluronan biosynthetic process | 1.5748 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| BTBD8_HUMAN | [view interactions] | Low throughput | no | yes |
| DVL2_HUMAN | [view interactions] | Low throughput | no | yes |
| KCND2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NUMB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RBP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ITSN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EHD1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NAGPA_HUMAN | [view interactions] | Low throughput | no | no |
| SYNJ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BIN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ATG9A_HUMAN | [view interactions] | Low throughput | no | yes |
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| NMDE2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PI51C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FCHO2_HUMAN | [view interactions] | Low throughput | no | yes |
| SGIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EPS15_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DPYL2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| L1CAM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CD22_HUMAN | [view interactions] | Low throughput | no | no |
| RFIP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AMPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BRCA1_HUMAN | [view interactions] | Low throughput | no | yes |
| REPS2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EPN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MYO6_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ARRB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ABCBB_HUMAN | [view interactions] | Low throughput | no | no |
| AAGAB_HUMAN | [view interactions] | Low throughput | no | yes |
| AP2S1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EPN4_HUMAN | [view interactions] | Low throughput | no | yes |
| ARF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MTMR4_HUMAN | [view interactions] | High throughput | no | no |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| BRD7_HUMAN | [view interactions] | High throughput | no | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| SHC2_HUMAN | [view interactions] | High throughput | no | yes |
| CCD32_HUMAN | [view interactions] | High throughput | no | yes |
| AP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZCH10_HUMAN | [view interactions] | High throughput | no | yes |
| INSY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MEA1_HUMAN | [view interactions] | High throughput | no | no |
| ZBTB3_HUMAN | [view interactions] | High throughput | no | yes |
| EP15R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| BRD3_HUMAN | [view interactions] | High throughput | no | yes |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ROA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NECP1_HUMAN | [view interactions] | High throughput | no | no |
| SF3B1_HUMAN | [view interactions] | High throughput | no | yes |
| PTN23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF2B3_HUMAN | [view interactions] | High throughput | no | no |
| TLS1_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| E2F4_HUMAN | [view interactions] | High throughput | no | no |
| ATG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| RNF8_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GATA4_HUMAN | [view interactions] | High throughput | no | no |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| SLX4_HUMAN | [view interactions] | High throughput | no | yes |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMAD9_HUMAN | [view interactions] | High throughput | no | yes |
| BMP2K_HUMAN | [view interactions] | High throughput | no | yes |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRB7_HUMAN | [view interactions] | High throughput | no | no |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP11_HUMAN | [view interactions] | High throughput | no | yes |
| PP6R3_HUMAN | [view interactions] | High throughput | no | yes |
| MET14_HUMAN | [view interactions] | High throughput | no | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| AAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIDN_HUMAN | [view interactions] | High throughput | no | no |
| GOLM1_HUMAN | [view interactions] | High throughput | no | yes |
| ESYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| SHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP36_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| BCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL4B_HUMAN | [view interactions] | High throughput | no | yes |
| LYRIC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLC4G_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| NTF2_HUMAN | [view interactions] | High throughput | no | yes |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| EI2BA_HUMAN | [view interactions] | High throughput | no | yes |
| SPS2L_HUMAN | [view interactions] | High throughput | no | yes |
| SYT3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| H2B2C_HUMAN | [view interactions] | High throughput | no | no |
| DYN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PACS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNP29_HUMAN | [view interactions] | High throughput | no | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYT7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| CCNB1_HUMAN | [view interactions] | High throughput | no | no |
| DAB2_HUMAN | [view interactions] | High throughput | no | yes |
| AMRP_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRAF2_HUMAN | [view interactions] | High throughput | no | yes |
| DUX4_HUMAN | [view interactions] | High throughput | no | no |
| LYRM7_HUMAN | [view interactions] | High throughput | no | yes |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| ERO1A_HUMAN | [view interactions] | High throughput | no | yes |
| MED4_HUMAN | [view interactions] | High throughput | no | yes |
| MAT2B_HUMAN | [view interactions] | High throughput | no | yes |
| MED23_HUMAN | [view interactions] | High throughput | no | no |
| NUP50_HUMAN | [view interactions] | High throughput | no | yes |
| M3K9_HUMAN | [view interactions] | High throughput | no | yes |
| PPM1H_HUMAN | [view interactions] | High throughput | no | yes |
| WNK3_HUMAN | [view interactions] | High throughput | no | no |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MIB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| CPEB4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTIF_HUMAN | [view interactions] | High throughput | no | yes |
| MEX3B_HUMAN | [view interactions] | High throughput | no | no |
| PATL1_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| SMAP2_HUMAN | [view interactions] | High throughput | no | yes |
| RNPS1_HUMAN | [view interactions] | High throughput | no | yes |
| TNR6A_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNR6B_HUMAN | [view interactions] | High throughput | no | yes |
| TNR6C_HUMAN | [view interactions] | High throughput | no | no |
| SNP25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX3X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EST1A_HUMAN | [view interactions] | High throughput | no | yes |
| SMG7_HUMAN | [view interactions] | High throughput | no | no |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| DERL1_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCKP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PEX5R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| FURIN_HUMAN | [view interactions] | High throughput | no | yes |
| AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| LITD1_HUMAN | [view interactions] | High throughput | no | no |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLD2_HUMAN | [view interactions] | High throughput | no | no |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| TBCD5_HUMAN | [view interactions] | High throughput | no | yes |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| TOE1_HUMAN | [view interactions] | High throughput | no | yes |
| KC1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EDC4_HUMAN | [view interactions] | High throughput | no | yes |
| CRK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB32_HUMAN | [view interactions] | High throughput | no | yes |
| DSCAM_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| CE128_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| TANK_HUMAN | [view interactions] | High throughput | no | yes |
| SHBG_HUMAN | [view interactions] | High throughput | no | no |
| SH3K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRK5_HUMAN | [view interactions] | High throughput | no | yes |
| ABL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| RARA_HUMAN | [view interactions] | High throughput | no | no |
| MMS19_HUMAN | [view interactions] | High throughput | no | yes |
| RNF11_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA2_HUMAN | [view interactions] | High throughput | no | no |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| S2541_HUMAN | [view interactions] | High throughput | no | no |
| NECP2_HUMAN | [view interactions] | High throughput | no | yes |
| LRFN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBT46_HUMAN | [view interactions] | High throughput | no | no |
| SPC25_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PDLI7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SC16A_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GTSE1_HUMAN | [view interactions] | High throughput | no | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| MYO5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| ARX_HUMAN | [view interactions] | High throughput | no | no |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFA97_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CD2AP_HUMAN | [view interactions] | High throughput | no | no |
| MCM3_HUMAN | [view interactions] | High throughput | no | no |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| USO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLNB_HUMAN | [view interactions] | High throughput | no | no |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| MEX3C_HUMAN | [view interactions] | High throughput | no | yes |
| UTP25_HUMAN | [view interactions] | High throughput | no | yes |
| ZN746_HUMAN | [view interactions] | High throughput | no | no |
| ARFG1_HUMAN | [view interactions] | High throughput | no | no |
| SNX9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUN3A_HUMAN | [view interactions] | High throughput | no | yes |
| GP156_HUMAN | [view interactions] | High throughput | no | no |
| GPBL1_HUMAN | [view interactions] | High throughput | no | yes |
| FCHO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PICAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INT4_HUMAN | [view interactions] | High throughput | no | yes |
| SOST_HUMAN | [view interactions] | High throughput | no | no |
| STABP_HUMAN | [view interactions] | High throughput | no | yes |
| REPS1_HUMAN | [view interactions] | High throughput | no | yes |
| PP6R2_HUMAN | [view interactions] | High throughput | no | no |
| LSR_HUMAN | [view interactions] | High throughput | no | yes |
| NKAP1_HUMAN | [view interactions] | High throughput | no | yes |
| CXB7_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| LNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMR1A_HUMAN | [view interactions] | High throughput | no | no |
| DX39B_HUMAN | [view interactions] | High throughput | no | no |
| DIM1_HUMAN | [view interactions] | High throughput | no | yes |
| QCR7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| ARI1_HUMAN | [view interactions] | High throughput | no | yes |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| AGO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| DCPS_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TXNIP_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA2_HUMAN | [view interactions] | High throughput | no | no |
| RC3H1_HUMAN | [view interactions] | High throughput | no | yes |
| RC3H2_HUMAN | [view interactions] | High throughput | no | yes |
| KCD15_HUMAN | [view interactions] | High throughput | no | no |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| TF3B_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CC14A_HUMAN | [view interactions] | High throughput | no | yes |
| AUXI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |