Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PDLI7_HUMAN

GO
G2C
SynGO

May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway . [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in PDLI7_HUMAN
GO:0003779 actin binding 36.3636 4 yes
GO:0046872 metal ion binding 36.3636 4 yes
GO:0019900 kinase binding 23.8636 4 no
GO:0017076 purine nucleotide binding 22.7273 4 no
GO:0019901 protein kinase binding 21.5909 5 no
GO:0030554 adenyl nucleotide binding 21.5909 5 no
GO:0045296 cadherin binding 20.4545 4 no
GO:0032555 purine ribonucleotide binding 20.4545 4 no
GO:0035639 purine ribonucleoside triphosphate binding 20.4545 4 no
GO:0042805 actinin binding 2.2727 4 yes
GO:0051371 muscle alpha-actinin binding 2.2727 6 yes
GO:0051393 alpha-actinin binding 2.2727 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PDLI7_HUMAN
GO:0048522 positive regulation of cellular process 53.4091 4 yes
GO:0060255 regulation of macromolecule metabolic process 52.2727 4 no
GO:0051171 regulation of nitrogen compound metabolic process 47.7273 4 no
GO:0080090 regulation of primary metabolic process 47.7273 4 no
GO:0031323 regulation of cellular metabolic process 47.7273 4 no
GO:0051128 regulation of cellular component organization 46.5909 4 no
GO:0048523 negative regulation of cellular process 45.4545 4 no
GO:0006996 organelle organization 43.1818 4 yes
GO:0010468 regulation of gene expression 37.5000 5 no
GO:0022607 cellular component assembly 34.0909 4 no
GO:0009889 regulation of biosynthetic process 32.9545 4 no
GO:0010556 regulation of macromolecule biosynthetic process 32.9545 5 no
GO:0009893 positive regulation of metabolic process 32.9545 4 no
GO:0010646 regulation of cell communication 32.9545 4 no
GO:0008104 protein localization 31.8182 4 no
GO:0033043 regulation of organelle organization 31.8182 5 no
GO:0051246 regulation of protein metabolic process 30.6818 5 no
GO:0031326 regulation of cellular biosynthetic process 30.6818 5 no
GO:0009966 regulation of signal transduction 29.5455 4 no
GO:0051049 regulation of transport 29.5455 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 29.5455 5 no
GO:0010604 positive regulation of macromolecule metabolic process 28.4091 5 no
GO:0051252 regulation of RNA metabolic process 28.4091 5 no
GO:0044087 regulation of cellular component biogenesis 28.4091 4 no
GO:0007010 cytoskeleton organization 27.2727 5 yes
GO:0009892 negative regulation of metabolic process 27.2727 4 no
GO:0016192 vesicle-mediated transport 26.1364 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 26.1364 5 no
GO:0031325 positive regulation of cellular metabolic process 26.1364 5 no
GO:1902531 regulation of intracellular signal transduction 26.1364 5 no
GO:1903506 regulation of nucleic acid-templated transcription 26.1364 7 no
GO:2001141 regulation of RNA biosynthetic process 26.1364 6 no
GO:0097435 supramolecular fiber organization 26.1364 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 25.0000 5 no
GO:0006355 regulation of DNA-templated transcription 25.0000 6 no
GO:0051172 negative regulation of nitrogen compound metabolic process 23.8636 5 no
GO:0051493 regulation of cytoskeleton organization 23.8636 6 no
GO:0060341 regulation of cellular localization 23.8636 4 no
GO:0007015 actin filament organization 23.8636 5 no
GO:0036211 protein modification process 22.7273 4 no
GO:0043412 macromolecule modification 22.7273 4 no
GO:0015031 protein transport 21.5909 4 no
GO:0032880 regulation of protein localization 21.5909 5 no
GO:0071702 organic substance transport 21.5909 4 no
GO:0071705 nitrogen compound transport 21.5909 4 no
GO:0031324 negative regulation of cellular metabolic process 21.5909 5 no
GO:0048584 positive regulation of response to stimulus 21.5909 4 no
GO:0032970 regulation of actin filament-based process 21.5909 4 no
GO:0051050 positive regulation of transport 20.4545 4 no
GO:0010647 positive regulation of cell communication 20.4545 5 no
GO:0023056 positive regulation of signaling 20.4545 4 no
GO:0071310 cellular response to organic substance 20.4545 4 no
GO:0032956 regulation of actin cytoskeleton organization 20.4545 5 no
GO:0006897 endocytosis 14.7727 5 yes
GO:0045595 regulation of cell differentiation 13.6364 4 yes
GO:0006898 receptor-mediated endocytosis 10.2273 6 yes
GO:0051094 positive regulation of developmental process 10.2273 4 yes
GO:0045597 positive regulation of cell differentiation 9.0909 5 yes
GO:0007507 heart development 2.2727 4 yes
GO:0045667 regulation of osteoblast differentiation 2.2727 5 yes
GO:0045669 positive regulation of osteoblast differentiation 2.2727 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in PDLI7_HUMAN
DOID:114 heart disease 6.8182 3 no
DOID:0050700 cardiomyopathy 5.6818 4 no
DOID:0060036 intrinsic cardiomyopathy 5.6818 5 no
DOID:0080000 muscular disease 4.5455 3 no
DOID:423 myopathy 4.5455 5 no
DOID:66 muscle tissue disease 4.5455 4 no
DOID:12930 dilated cardiomyopathy 3.4091 6 no
DOID:557 kidney disease 3.4091 3 no
DOID:2843 long QT syndrome 2.2727 6 no
DOID:3191 nemaline myopathy 2.2727 7 no
DOID:422 congenital structural myopathy 2.2727 6 no
DOID:331 central nervous system disease 2.2727 3 no
DOID:37 skin disease 2.2727 3 no
DOID:0050851 glomerulosclerosis 2.2727 6 no
DOID:10952 nephritis 2.2727 4 no
DOID:1312 focal segmental glomerulosclerosis 2.2727 7 no
DOID:2921 glomerulonephritis 2.2727 5 no
DOID:1247 blood coagulation disease 2.2727 3 no
DOID:2218 blood platelet disease 2.2727 4 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KPCB_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCZ_HUMAN [view entry] [view interactions] Low throughput yes yes
ZMY11_HUMAN [view interactions] Low throughput no no
CBLC_HUMAN [view interactions] Low throughput no yes
TPM2_HUMAN [view entry] [view interactions] Low throughput yes yes
RET_HUMAN [view interactions] Low throughput no yes
SMUF1_HUMAN [view interactions] Low throughput no yes
MDM2_HUMAN [view interactions] Low throughput no yes
P53_HUMAN [view interactions] Low throughput no no
NR2C2_HUMAN [view interactions] Low throughput no yes
TAB2_HUMAN [view interactions] Low throughput no yes
TRAF6_HUMAN [view interactions] Low throughput no yes
TRADD_HUMAN [view interactions] Low throughput no yes
SH2B2_HUMAN [view interactions] Low throughput no no
CSN5_HUMAN [view interactions] Low throughput no yes
NEDD4_HUMAN [view entry] [view interactions] Low throughput yes yes
RNF31_HUMAN [view interactions] Low throughput no yes
HOIL1_HUMAN [view interactions] Low throughput no no
SHRPN_HUMAN [view entry] [view interactions] Low throughput yes yes
TRAF2_HUMAN [view interactions] Low throughput no yes
TRAF3_HUMAN [view entry] [view interactions] Low throughput yes yes
ELOB_HUMAN [view interactions] High throughput no no
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
ARPC4_HUMAN [view entry] [view interactions] High throughput yes no
SPTB2_HUMAN [view entry] [view interactions] High throughput yes yes
ACTN4_HUMAN [view entry] [view interactions] High throughput yes yes
CBPM_HUMAN [view interactions] High throughput no no
CALL3_HUMAN [view interactions] High throughput no yes
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
SYVC_HUMAN [view interactions] High throughput no yes
GNAI2_HUMAN [view entry] [view interactions] High throughput yes yes
MYO1E_HUMAN [view entry] [view interactions] High throughput yes yes
SPTN1_HUMAN [view entry] [view interactions] High throughput yes yes
REPI1_HUMAN [view interactions] High throughput no yes
ARPC3_HUMAN [view entry] [view interactions] High throughput yes yes
EPS15_HUMAN [view entry] [view interactions] High throughput yes yes
AKAP2_HUMAN [view interactions] High throughput no no
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
MISP_HUMAN [view interactions] High throughput no no
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
ARP3_HUMAN [view entry] [view interactions] High throughput yes yes
TMOD1_HUMAN [view entry] [view interactions] High throughput yes yes
LUZP1_HUMAN [view interactions] High throughput no yes
MYO5C_HUMAN [view entry] [view interactions] High throughput yes yes
DHSO_HUMAN [view interactions] High throughput no no
ARP5L_HUMAN [view entry] [view interactions] High throughput yes yes
CYTSA_HUMAN [view interactions] High throughput no yes
ML12A_HUMAN [view interactions] High throughput no no
ABLM1_HUMAN [view entry] [view interactions] High throughput yes yes
ACTT1_HUMAN [view interactions] High throughput no no
ARPC2_HUMAN [view entry] [view interactions] High throughput yes yes
NF2IP_HUMAN [view interactions] High throughput no no
PRIC3_HUMAN [view interactions] High throughput no yes
IKZF5_HUMAN [view interactions] High throughput no no
LPXN_HUMAN [view interactions] High throughput no yes
FHL5_HUMAN [view interactions] High throughput no no
LIMD1_HUMAN [view interactions] High throughput no yes
PDLI5_HUMAN [view entry] [view interactions] High throughput yes no
ZBT10_HUMAN [view interactions] High throughput no yes
LPP_HUMAN [view interactions] High throughput no yes
SLN12_HUMAN [view interactions] High throughput no no
PTN14_HUMAN [view interactions] High throughput no yes
TRIP6_HUMAN [view interactions] High throughput no yes
ZN576_HUMAN [view interactions] High throughput no no
THB_HUMAN [view interactions] High throughput no no
ZCHC7_HUMAN [view interactions] High throughput no yes
ETV7_HUMAN [view interactions] High throughput no no
SYT11_HUMAN [view entry] [view interactions] High throughput yes yes
VPS28_HUMAN [view entry] [view interactions] High throughput yes yes
TS101_HUMAN [view entry] [view interactions] High throughput yes yes
MB12A_HUMAN [view interactions] High throughput no yes
ACTN2_HUMAN [view entry] [view interactions] High throughput yes yes
VP37C_HUMAN [view interactions] High throughput no yes
UBE2O_HUMAN [view interactions] High throughput no yes
WWC3_HUMAN [view interactions] High throughput no yes
FAT2_HUMAN [view interactions] High throughput no no
VP37B_HUMAN [view interactions] High throughput no yes
VP37A_HUMAN [view interactions] High throughput no yes
K1C26_HUMAN [view interactions] High throughput no no
KPRP_HUMAN [view interactions] High throughput no no
F110C_HUMAN [view interactions] High throughput no yes
ZYX_HUMAN [view interactions] High throughput no no
ABRX2_HUMAN [view interactions] High throughput no yes
K2C6C_HUMAN [view interactions] High throughput no no
ZA2G_HUMAN [view interactions] High throughput no no
LYAG_HUMAN [view interactions] High throughput no yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
RRP1B_HUMAN [view interactions] High throughput no yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
UBQL4_HUMAN [view interactions] High throughput no yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
TRI54_HUMAN [view interactions] High throughput no no
SNW1_HUMAN [view interactions] High throughput no yes
CDC5L_HUMAN [view interactions] High throughput no yes
ANGI_HUMAN [view interactions] High throughput no no
RYBP_HUMAN [view interactions] High throughput no no
PCBP1_HUMAN [view entry] [view interactions] High throughput yes yes
3BP2_HUMAN [view interactions] High throughput no yes
PHF1_HUMAN [view interactions] High throughput no yes
WWP2_HUMAN [view interactions] High throughput no no
HNRPF_HUMAN [view interactions] High throughput no yes
OTU6A_HUMAN [view interactions] High throughput no no
SCNM1_HUMAN [view interactions] High throughput no no
GEM_HUMAN [view interactions] High throughput no yes
PARVG_HUMAN [view interactions] High throughput no yes
F90A1_HUMAN [view interactions] High throughput no no
NUD10_HUMAN [view interactions] High throughput no yes
F214B_HUMAN [view interactions] High throughput no yes
ENKD1_HUMAN [view interactions] High throughput no yes
KANK2_HUMAN [view entry] [view interactions] High throughput yes yes
PIN1_HUMAN [view entry] [view interactions] High throughput yes yes
CTSR1_HUMAN [view interactions] High throughput no no
FA71C_HUMAN [view interactions] High throughput no no
SLAI1_HUMAN [view interactions] High throughput no no
HSF2B_HUMAN [view interactions] High throughput no yes
HEY2_HUMAN [view interactions] High throughput no no
HSPB7_HUMAN [view interactions] High throughput no yes
DNER_HUMAN [view interactions] High throughput no yes
T10IP_HUMAN [view interactions] High throughput no no
TCF19_HUMAN [view interactions] High throughput no no
GPT2L_HUMAN [view interactions] High throughput no yes
FRS3_HUMAN [view interactions] High throughput no no
DDX6_HUMAN [view entry] [view interactions] High throughput yes yes
RPP25_HUMAN [view interactions] High throughput no yes
ZN165_HUMAN [view interactions] High throughput no no
PAK5_HUMAN [view interactions] High throughput no yes
GFAP_HUMAN [view entry] [view interactions] High throughput yes no
OSTP_HUMAN [view interactions] High throughput no yes
UBC9_HUMAN [view interactions] High throughput no yes
CC185_HUMAN [view interactions] High throughput no no
BASI_HUMAN [view entry] [view interactions] High throughput yes no
FND11_HUMAN [view interactions] High throughput no no
CDK1_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
RAB3I_HUMAN [view interactions] High throughput no no
ESR1_HUMAN [view interactions] High throughput no no
NINL_HUMAN [view interactions] High throughput no yes
CE128_HUMAN [view interactions] High throughput no yes
INSR_HUMAN [view interactions] High throughput no yes
TPC10_HUMAN [view interactions] High throughput no no
M21D2_HUMAN [view interactions] High throughput no yes
TPPC1_HUMAN [view interactions] High throughput no yes
TPPC4_HUMAN [view entry] [view interactions] High throughput yes yes
TPC2L_HUMAN [view interactions] High throughput no yes
TPPC9_HUMAN [view entry] [view interactions] High throughput yes no
R3GEF_HUMAN [view interactions] High throughput no yes
TM102_HUMAN [view interactions] High throughput no no
TPPC3_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPD_HUMAN [view entry] [view interactions] High throughput yes yes
PSMF1_HUMAN [view interactions] High throughput no yes
AP5B1_HUMAN [view interactions] High throughput no yes
DGCR6_HUMAN [view interactions] High throughput no no
IQGA1_HUMAN [view entry] [view interactions] High throughput yes no
TNPO2_HUMAN [view interactions] High throughput no yes
ABI2_HUMAN [view entry] [view interactions] High throughput yes yes
RGF1B_HUMAN [view interactions] High throughput no no
IL16_HUMAN [view interactions] High throughput no no
PKHN1_HUMAN [view interactions] High throughput no yes
DMRT2_HUMAN [view interactions] High throughput no no
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
GLYM_HUMAN [view entry] [view interactions] High throughput yes yes
NXF1_HUMAN [view interactions] High throughput no yes
OBSL1_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
LUZP4_HUMAN [view interactions] High throughput no no
HBB_HUMAN [view interactions] High throughput no no
AP2A1_HUMAN [view entry] [view interactions] High throughput yes yes
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
AP2M1_HUMAN [view entry] [view interactions] High throughput yes yes
CLCA_HUMAN [view entry] [view interactions] High throughput yes no
CLCB_HUMAN [view entry] [view interactions] High throughput yes yes
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
MYO5A_HUMAN [view entry] [view interactions] High throughput yes yes
PLEC_HUMAN [view entry] [view interactions] High throughput yes yes
TPM1_HUMAN [view entry] [view interactions] High throughput yes no
TPM3_HUMAN [view entry] [view interactions] High throughput yes yes
YES_HUMAN [view entry] [view interactions] High throughput yes yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
PALLD_HUMAN [view interactions] High throughput no yes
MPRIP_HUMAN [view entry] [view interactions] High throughput yes yes
RAI14_HUMAN [view interactions] High throughput no yes
QSER1_HUMAN [view interactions] High throughput no yes
RGS3_HUMAN [view interactions] High throughput no no
RPGR_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
TES_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
RNF4_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
DYR1A_HUMAN [view interactions] High throughput no yes
AGO2_HUMAN [view interactions] High throughput no yes
WWP1_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
CTIP_HUMAN [view interactions] High throughput no no
BAG5_HUMAN [view entry] [view interactions] High throughput yes no
UBQL2_HUMAN [view interactions] High throughput no yes
WDR5_HUMAN [view interactions] High throughput no no
AJUBA_HUMAN [view interactions] High throughput no yes
CISD1_HUMAN [view entry] [view interactions] High throughput yes yes
CDPF1_HUMAN [view interactions] High throughput no no
TRPC3_HUMAN [view interactions] High throughput no no
ABLM3_HUMAN [view entry] [view interactions] High throughput yes yes
RNF10_HUMAN [view entry] [view interactions] High throughput yes yes
CJ090_HUMAN [view interactions] High throughput no no
N42L1_HUMAN [view interactions] High throughput no yes
KLHL6_HUMAN [view interactions] High throughput no no
TAD2A_HUMAN [view interactions] High throughput no no
RGPD1_HUMAN [view interactions] High throughput no no
F163B_HUMAN [view interactions] High throughput no yes
GRN_HUMAN [view interactions] High throughput no no
KLHL8_HUMAN [view interactions] High throughput no no
HSPB8_HUMAN [view entry] [view interactions] High throughput yes yes
SI1L2_HUMAN [view interactions] High throughput no yes
FHL1_HUMAN [view interactions] High throughput no no
BTF3_HUMAN [view interactions] High throughput no yes
FBXW7_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
BRD2_HUMAN [view interactions] High throughput no yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
EEA1_HUMAN [view entry] [view interactions] High throughput yes yes
IPO13_HUMAN [view interactions] High throughput no yes
MP2K7_HUMAN [view entry] [view interactions] High throughput yes yes
PTSS1_HUMAN [view interactions] High throughput no no
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA7_HUMAN [view entry] [view interactions] High throughput yes yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
GBF1_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
MEX3B_HUMAN [view interactions] High throughput no no
SMAG2_HUMAN [view interactions] High throughput no yes
LZTS2_HUMAN [view interactions] High throughput no no
YAP1_HUMAN [view interactions] High throughput no yes
RN183_HUMAN [view interactions] High throughput no no
KPCD2_HUMAN [view interactions] High throughput no yes
PARD3_HUMAN [view interactions] High throughput no yes
HXA1_HUMAN [view interactions] High throughput no no
PERI_HUMAN [view entry] [view interactions] High throughput yes no
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
SQSTM_HUMAN [view interactions] High throughput no yes
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
SYNE3_HUMAN [view interactions] High throughput no no
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
VIME_HUMAN [view entry] [view interactions] High throughput yes no
TPM4_HUMAN [view entry] [view interactions] High throughput yes yes
RNF43_HUMAN [view interactions] High throughput no yes
ACTN1_HUMAN [view entry] [view interactions] High throughput yes yes
COBL_HUMAN [view interactions] High throughput no yes
SOAT1_HUMAN [view interactions] High throughput no no
BMP2K_HUMAN [view interactions] High throughput no yes
SVIL_HUMAN [view interactions] High throughput no yes
MYL6_HUMAN [view entry] [view interactions] High throughput yes no
GBB1_HUMAN [view entry] [view interactions] High throughput yes yes
MYL6B_HUMAN [view entry] [view interactions] High throughput yes no
TPRN_HUMAN [view interactions] High throughput no yes
CE162_HUMAN [view interactions] High throughput no yes
MYO1B_HUMAN [view entry] [view interactions] High throughput yes no
GFRA1_HUMAN [view interactions] Computational no no
TM38A_HUMAN [view interactions] Computational no yes
SRCA_HUMAN [view interactions] Computational no no
TNNC2_HUMAN [view interactions] Computational no no
MYL1_HUMAN [view interactions] Computational no no
GDNF_HUMAN [view interactions] Computational no yes