Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MPRIP_HUMAN

Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in MPRIP_HUMAN
GO:0045296 cadherin binding 30.6818 4 yes
GO:0043169 cation binding 29.5455 4 no
GO:0046872 metal ion binding 29.5455 5 no
GO:0003779 actin binding 28.4091 4 yes
GO:0019900 kinase binding 28.4091 4 no
GO:0019901 protein kinase binding 28.4091 5 no
GO:0043168 anion binding 26.1364 4 no
GO:0000166 nucleotide binding 23.8636 4 no
GO:0017076 purine nucleotide binding 23.8636 5 no
GO:0032555 purine ribonucleotide binding 22.7273 4 no
GO:0030554 adenyl nucleotide binding 21.5909 6 no
GO:0032559 adenyl ribonucleotide binding 20.4545 5 no
GO:0035639 purine ribonucleoside triphosphate binding 20.4545 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in MPRIP_HUMAN
GO:0048522 positive regulation of cellular process 69.3182 4 no
GO:0031323 regulation of cellular metabolic process 59.0909 4 no
GO:0048523 negative regulation of cellular process 59.0909 4 no
GO:0060255 regulation of macromolecule metabolic process 57.9545 4 no
GO:0080090 regulation of primary metabolic process 51.1364 4 no
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0010646 regulation of cell communication 48.8636 4 no
GO:0008104 protein localization 42.0455 4 no
GO:0009893 positive regulation of metabolic process 42.0455 4 no
GO:0051246 regulation of protein metabolic process 40.9091 5 no
GO:0006996 organelle organization 40.9091 4 no
GO:0009966 regulation of signal transduction 40.9091 4 no
GO:0031326 regulation of cellular biosynthetic process 39.7727 5 no
GO:0009889 regulation of biosynthetic process 39.7727 4 no
GO:0010468 regulation of gene expression 39.7727 6 no
GO:0010556 regulation of macromolecule biosynthetic process 39.7727 5 no
GO:0010604 positive regulation of macromolecule metabolic process 38.6364 5 no
GO:0031325 positive regulation of cellular metabolic process 34.0909 5 no
GO:0051049 regulation of transport 34.0909 4 no
GO:0022607 cellular component assembly 32.9545 4 no
GO:0031399 regulation of protein modification process 30.6818 6 no
GO:0044087 regulation of cellular component biogenesis 30.6818 4 no
GO:0048584 positive regulation of response to stimulus 30.6818 4 no
GO:1902531 regulation of intracellular signal transduction 30.6818 5 no
GO:0009892 negative regulation of metabolic process 30.6818 4 no
GO:0010605 negative regulation of macromolecule metabolic process 28.4091 5 no
GO:0051247 positive regulation of protein metabolic process 28.4091 6 no
GO:0007010 cytoskeleton organization 27.2727 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 26.1364 5 no
GO:0036211 protein modification process 26.1364 4 no
GO:0043412 macromolecule modification 26.1364 4 no
GO:0031324 negative regulation of cellular metabolic process 26.1364 5 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0019220 regulation of phosphate metabolic process 25.0000 6 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0051174 regulation of phosphorus metabolic process 25.0000 5 no
GO:0051252 regulation of RNA metabolic process 25.0000 5 no
GO:2001141 regulation of RNA biosynthetic process 25.0000 6 no
GO:0033043 regulation of organelle organization 25.0000 5 no
GO:0006355 regulation of DNA-templated transcription 25.0000 7 no
GO:0051129 negative regulation of cellular component organization 23.8636 5 no
GO:0051240 positive regulation of multicellular organismal process 23.8636 4 no
GO:0031344 regulation of cell projection organization 23.8636 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 23.8636 6 no
GO:0030030 cell projection organization 23.8636 4 no
GO:0048585 negative regulation of response to stimulus 22.7273 4 no
GO:0141124 intracellular signaling cassette 22.7273 4 no
GO:0051130 positive regulation of cellular component organization 22.7273 5 no
GO:0060341 regulation of cellular localization 22.7273 4 no
GO:0009967 positive regulation of signal transduction 22.7273 5 no
GO:0010648 negative regulation of cell communication 21.5909 5 no
GO:0023057 negative regulation of signaling 21.5909 4 no
GO:0031328 positive regulation of cellular biosynthetic process 21.5909 6 no
GO:0042981 regulation of apoptotic process 21.5909 5 no
GO:0043067 regulation of programmed cell death 21.5909 4 no
GO:0045595 regulation of cell differentiation 21.5909 4 no
GO:0009891 positive regulation of biosynthetic process 21.5909 5 no
GO:0009968 negative regulation of signal transduction 21.5909 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 21.5909 6 no
GO:0031401 positive regulation of protein modification process 20.4545 7 no
GO:0042325 regulation of phosphorylation 20.4545 7 no
GO:0032970 regulation of actin filament-based process 20.4545 4 no
GO:0009894 regulation of catabolic process 20.4545 4 no
GO:0032880 regulation of protein localization 20.4545 5 no
GO:0051493 regulation of cytoskeleton organization 20.4545 6 no
GO:0051094 positive regulation of developmental process 20.4545 4 no
GO:2000026 regulation of multicellular organismal development 20.4545 4 no
GO:0022603 regulation of anatomical structure morphogenesis 20.4545 4 no
GO:0120036 plasma membrane bounded cell projection organization 20.4545 5 no
GO:0001932 regulation of protein phosphorylation 20.4545 7 no

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RHOA_HUMAN [view entry] [view interactions] Low throughput yes yes
TRI58_HUMAN [view interactions] Low throughput no no
MYPT1_HUMAN [view entry] [view interactions] Low throughput yes yes
MPRIP_HUMAN [view entry] [view interactions] Low throughput yes yes
PP12C_HUMAN [view interactions] Low throughput no yes
PK3CA_HUMAN [view entry] [view interactions] High throughput yes yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
CENPJ_HUMAN [view interactions] High throughput no no
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
CENPC_HUMAN [view interactions] High throughput no no
CD3Z_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
NUAK1_HUMAN [view interactions] High throughput no no
PLK1_HUMAN [view interactions] High throughput no yes
HASP_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
BCAR1_HUMAN [view interactions] High throughput no yes
MYCB2_HUMAN [view entry] [view interactions] High throughput yes no
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
BMI1_HUMAN [view interactions] High throughput no yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
ANK2_HUMAN [view entry] [view interactions] High throughput yes yes
CEP63_HUMAN [view interactions] High throughput no yes
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
SMCA2_HUMAN [view interactions] High throughput no yes
M3K3_HUMAN [view interactions] High throughput no no
RIPK3_HUMAN [view interactions] High throughput no no
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
CDK1_HUMAN [view interactions] High throughput no no
RAI14_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
DSCAM_HUMAN [view interactions] High throughput no yes
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
PSA1_HUMAN [view interactions] High throughput no yes
FOS_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
EPHA2_HUMAN [view interactions] High throughput no no
FGFR2_HUMAN [view interactions] High throughput no yes
LTK_HUMAN [view interactions] High throughput no no
NTRK2_HUMAN [view entry] [view interactions] High throughput yes yes
KCNK3_HUMAN [view interactions] High throughput no no
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
CK024_HUMAN [view interactions] High throughput no yes
UACA_HUMAN [view interactions] High throughput no yes
TRI69_HUMAN [view interactions] High throughput no no
SAS6_HUMAN [view interactions] High throughput no no
POC1B_HUMAN [view interactions] High throughput no no
CEP76_HUMAN [view interactions] High throughput no yes
FBX25_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
PAN2_HUMAN [view interactions] High throughput no no
RFA3_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
SGF29_HUMAN [view interactions] High throughput no yes
WDR83_HUMAN [view interactions] High throughput no yes
SERC_HUMAN [view interactions] High throughput no yes
PRS6A_HUMAN [view entry] [view interactions] High throughput yes yes
FNDC4_HUMAN [view interactions] High throughput no no
PACN2_HUMAN [view entry] [view interactions] High throughput yes no
ZFP41_HUMAN [view interactions] High throughput no no
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
CDK2_HUMAN [view interactions] High throughput no yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
PP1B_HUMAN [view entry] [view interactions] High throughput yes yes
IQGA1_HUMAN [view entry] [view interactions] High throughput yes no
PDLI7_HUMAN [view entry] [view interactions] High throughput yes no
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
ANLN_HUMAN [view interactions] High throughput no yes
MYO19_HUMAN [view interactions] High throughput no yes
MY18A_HUMAN [view entry] [view interactions] High throughput yes yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
TMOD3_HUMAN [view interactions] High throughput no yes
CALL3_HUMAN [view interactions] High throughput no yes
ARMC7_HUMAN [view interactions] High throughput no yes
VAPB_HUMAN [view entry] [view interactions] High throughput yes yes
FBW1A_HUMAN [view interactions] High throughput no yes
JPH4_HUMAN [view interactions] High throughput no no
VAPA_HUMAN [view entry] [view interactions] High throughput yes yes
PACN1_HUMAN [view entry] [view interactions] High throughput yes yes
VTNC_HUMAN [view interactions] High throughput no no
NECA1_HUMAN [view interactions] High throughput no yes
MIA2_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
DX39B_HUMAN [view interactions] High throughput no no
ARNT_HUMAN [view entry] [view interactions] High throughput yes yes
KC1A_HUMAN [view interactions] High throughput no yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
RN138_HUMAN [view entry] [view interactions] High throughput yes no
MEP50_HUMAN [view interactions] High throughput no yes
TNIP2_HUMAN [view interactions] High throughput no yes
TNFA_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
TCTP_HUMAN [view entry] [view interactions] High throughput yes yes
UBP14_HUMAN [view entry] [view interactions] High throughput yes yes
PP1G_HUMAN [view entry] [view interactions] High throughput yes yes
DYR1A_HUMAN [view interactions] High throughput no yes
RU17_HUMAN [view interactions] High throughput no yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
PGRC1_HUMAN [view entry] [view interactions] High throughput yes yes
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
SQSTM_HUMAN [view interactions] High throughput no yes
PINK1_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
TFCP2_HUMAN [view interactions] High throughput no no
ACK1_HUMAN [view entry] [view interactions] High throughput yes yes
LRC31_HUMAN [view interactions] High throughput no no
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
CHM4C_HUMAN [view interactions] High throughput no yes
ECT2_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
KIF23_HUMAN [view interactions] High throughput no yes
NUPR1_HUMAN [view interactions] High throughput no no
ISG15_HUMAN [view interactions] High throughput no no
JPH3_HUMAN [view interactions] High throughput no no
LRSM1_HUMAN [view entry] [view interactions] High throughput yes yes
MTMRA_HUMAN [view interactions] High throughput no yes
SH3L1_HUMAN [view interactions] High throughput no yes
UB2V2_HUMAN [view entry] [view interactions] High throughput yes no
MALL_HUMAN [view interactions] High throughput no no
TM147_HUMAN [view interactions] High throughput no no
CXCL6_HUMAN [view interactions] High throughput no no
TYB4Y_HUMAN [view interactions] High throughput no no
MUCEN_HUMAN [view interactions] High throughput no yes
TPX2_HUMAN [view interactions] High throughput no yes
IF16_HUMAN [view interactions] High throughput no no
ACPH_HUMAN [view interactions] High throughput no yes
GAGE5_HUMAN [view interactions] High throughput no no
ANR50_HUMAN [view interactions] High throughput no no
RBX1_HUMAN [view entry] [view interactions] High throughput yes no
CX001_HUMAN [view interactions] High throughput no no
TARA_HUMAN [view interactions] High throughput no yes
FURIN_HUMAN [view interactions] High throughput no yes
QCR10_HUMAN [view interactions] High throughput no no
DPM2_HUMAN [view interactions] High throughput no yes
SAA1_HUMAN [view interactions] High throughput no no
TP4A3_HUMAN [view interactions] High throughput no no
SYCE1_HUMAN [view interactions] High throughput no no
OTUB2_HUMAN [view interactions] High throughput no no
CAN1_HUMAN [view entry] [view interactions] High throughput yes yes
ERLEC_HUMAN [view interactions] High throughput no yes
ZNF24_HUMAN [view interactions] High throughput no yes
NAA40_HUMAN [view interactions] High throughput no no
TRNT1_HUMAN [view interactions] High throughput no yes
H2B3B_HUMAN [view interactions] High throughput no yes
BTF3_HUMAN [view interactions] High throughput no yes
SEPT9_HUMAN [view interactions] High throughput no no
FBXW7_HUMAN [view interactions] High throughput no yes
FGD5_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
SIR6_HUMAN [view interactions] High throughput no yes
KCNA3_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
RND3_HUMAN [view interactions] High throughput no no
PLK4_HUMAN [view interactions] High throughput no yes
CALD1_HUMAN [view entry] [view interactions] High throughput yes no
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
SRC8_HUMAN [view entry] [view interactions] High throughput yes yes
PACN3_HUMAN [view interactions] High throughput no yes
RNF38_HUMAN [view interactions] High throughput no yes
HDAC6_HUMAN [view interactions] High throughput no yes
DOT1L_HUMAN [view interactions] High throughput no yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
UBE2O_HUMAN [view interactions] High throughput no yes
MYLK_HUMAN [view entry] [view interactions] High throughput yes no
GCSP_HUMAN [view interactions] High throughput no yes
TOP3B_HUMAN [view interactions] High throughput no no
UBP11_HUMAN [view interactions] High throughput no yes
MIDN_HUMAN [view interactions] High throughput no no
RN207_HUMAN [view interactions] High throughput no no
RICTR_HUMAN [view interactions] High throughput no yes
TNIP1_HUMAN [view interactions] High throughput no yes
MERL_HUMAN [view interactions] High throughput no yes
UBP7_HUMAN [view interactions] High throughput no yes
PDE4B_HUMAN [view entry] [view interactions] High throughput yes yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
ACTC_HUMAN [view interactions] High throughput no no
AP1AR_HUMAN [view interactions] High throughput no yes
DNJC5_HUMAN [view interactions] High throughput no yes
ARP3_HUMAN [view entry] [view interactions] High throughput yes yes
LCK_HUMAN [view entry] [view interactions] High throughput yes no
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
RADI_HUMAN [view entry] [view interactions] High throughput yes yes
TMOD1_HUMAN [view entry] [view interactions] High throughput yes yes
NRP1_HUMAN [view entry] [view interactions] High throughput yes yes
AMPN_HUMAN [view interactions] High throughput no no
DPP4_HUMAN [view interactions] High throughput no no
BASI_HUMAN [view entry] [view interactions] High throughput yes no
IFM3_HUMAN [view interactions] High throughput no yes
TM11B_HUMAN [view interactions] High throughput no no
ACE2_HUMAN [view interactions] High throughput no no
TMPS4_HUMAN [view interactions] High throughput no yes
SLN11_HUMAN [view interactions] High throughput no yes
PCBP1_HUMAN [view entry] [view interactions] High throughput yes yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
WWTR1_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
NOS3_HUMAN [view interactions] High throughput no no
ATX7_HUMAN [view interactions] High throughput no no
NEMO_HUMAN [view interactions] High throughput no yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
RGAP1_HUMAN [view interactions] High throughput no no
PIAS4_HUMAN [view interactions] High throughput no yes
LSM8_HUMAN [view interactions] High throughput no yes
YTDC1_HUMAN [view interactions] High throughput no yes
ARRB1_HUMAN [view entry] [view interactions] High throughput yes yes
TPM1_HUMAN [view entry] [view interactions] High throughput yes no
MYH10_HUMAN [view entry] [view interactions] High throughput yes yes
USO1_HUMAN [view entry] [view interactions] High throughput yes yes
PCM1_HUMAN [view interactions] High throughput no yes
FTM_HUMAN [view interactions] High throughput no yes
WRP73_HUMAN [view interactions] High throughput no no
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
ARHGB_HUMAN [view interactions] High throughput no yes
SYDE2_HUMAN [view interactions] High throughput no no
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
CHK2_HUMAN [view interactions] High throughput no yes
NF2L2_HUMAN [view interactions] High throughput no yes