CALD1_HUMAN
Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration . [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in CALD1_HUMAN |
---|---|---|---|---|
GO:0003779 | actin binding | 42.7184 | 4 | yes |
GO:0045296 | cadherin binding | 23.3010 | 4 | yes |
GO:0003723 | RNA binding | 23.3010 | 4 | no |
GO:0017076 | purine nucleotide binding | 21.3592 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 21.3592 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 21.3592 | 4 | no |
GO:0005524 | ATP binding | 20.3883 | 5 | no |
GO:0030554 | adenyl nucleotide binding | 20.3883 | 5 | no |
GO:0032559 | adenyl ribonucleotide binding | 20.3883 | 5 | no |
GO:0005523 | tropomyosin binding | 1.9417 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in CALD1_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 47.5728 | 4 | no |
GO:0051128 | regulation of cellular component organization | 46.6019 | 4 | no |
GO:0048523 | negative regulation of cellular process | 45.6311 | 4 | no |
GO:0006996 | organelle organization | 42.7184 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 41.7476 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 40.7767 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 38.8350 | 4 | no |
GO:0022607 | cellular component assembly | 37.8641 | 4 | yes |
GO:0007010 | cytoskeleton organization | 36.8932 | 5 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 36.8932 | 4 | no |
GO:0010646 | regulation of cell communication | 33.0097 | 4 | no |
GO:0097435 | supramolecular fiber organization | 32.0388 | 4 | yes |
GO:0051246 | regulation of protein metabolic process | 32.0388 | 5 | no |
GO:0033043 | regulation of organelle organization | 31.0680 | 5 | no |
GO:0044087 | regulation of cellular component biogenesis | 31.0680 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 30.0971 | 4 | no |
GO:0009966 | regulation of signal transduction | 29.1262 | 4 | no |
GO:0007015 | actin filament organization | 28.1553 | 5 | yes |
GO:0010468 | regulation of gene expression | 28.1553 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 28.1553 | 5 | no |
GO:0051493 | regulation of cytoskeleton organization | 26.2136 | 6 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 25.2427 | 5 | no |
GO:0009889 | regulation of biosynthetic process | 24.2718 | 4 | no |
GO:0031326 | regulation of cellular biosynthetic process | 24.2718 | 5 | no |
GO:0008104 | protein localization | 24.2718 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 23.3010 | 5 | no |
GO:0032970 | regulation of actin filament-based process | 23.3010 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 22.3301 | 5 | no |
GO:0030030 | cell projection organization | 22.3301 | 4 | no |
GO:0032956 | regulation of actin cytoskeleton organization | 22.3301 | 5 | no |
GO:0110053 | regulation of actin filament organization | 22.3301 | 6 | no |
GO:1902903 | regulation of supramolecular fiber organization | 22.3301 | 5 | no |
GO:0051049 | regulation of transport | 21.3592 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 21.3592 | 5 | no |
GO:0032535 | regulation of cellular component size | 21.3592 | 4 | no |
GO:0043254 | regulation of protein-containing complex assembly | 20.3883 | 5 | no |
GO:0051130 | positive regulation of cellular component organization | 20.3883 | 5 | no |
GO:0051017 | actin filament bundle assembly | 6.7961 | 5 | yes |
GO:0061572 | actin filament bundle organization | 6.7961 | 6 | yes |
GO:0006936 | muscle contraction | 4.8544 | 4 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in CALD1_HUMAN |
---|---|---|---|---|
DOID:114 | heart disease | 4.8544 | 3 | no |
DOID:0050700 | cardiomyopathy | 3.8835 | 4 | no |
DOID:0060036 | intrinsic cardiomyopathy | 3.8835 | 5 | no |
DOID:0050851 | glomerulosclerosis | 1.9417 | 6 | no |
DOID:10952 | nephritis | 1.9417 | 4 | no |
DOID:1312 | focal segmental glomerulosclerosis | 1.9417 | 7 | no |
DOID:2921 | glomerulonephritis | 1.9417 | 5 | no |
DOID:557 | kidney disease | 1.9417 | 3 | no |
DOID:2843 | long QT syndrome | 1.9417 | 6 | no |
DOID:0080326 | familial hypertrophic cardiomyopathy | 1.9417 | 7 | no |
DOID:11984 | hypertrophic cardiomyopathy | 1.9417 | 6 | no |
DOID:0080000 | muscular disease | 1.9417 | 3 | no |
DOID:423 | myopathy | 1.9417 | 5 | no |
DOID:66 | muscle tissue disease | 1.9417 | 4 | no |
DOID:1247 | blood coagulation disease | 1.9417 | 3 | no |
DOID:2218 | blood platelet disease | 1.9417 | 4 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
CALM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CALM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KAPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SHC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUA3_HUMAN | [view interactions] | High throughput | no | yes |
EFHD1_HUMAN | [view interactions] | High throughput | no | no |
K1671_HUMAN | [view interactions] | High throughput | no | yes |
ARP5L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
F162A_HUMAN | [view interactions] | High throughput | no | yes |
ARC1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRR11_HUMAN | [view interactions] | High throughput | no | no |
LRCH1_HUMAN | [view interactions] | High throughput | no | yes |
ASF1A_HUMAN | [view interactions] | High throughput | no | no |
NEB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CABIN_HUMAN | [view interactions] | High throughput | no | yes |
MYO5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYIM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DBNL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CNOT2_HUMAN | [view interactions] | High throughput | no | yes |
TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
RAI14_HUMAN | [view interactions] | High throughput | no | yes |
ARP3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ITPR2_HUMAN | [view interactions] | High throughput | no | yes |
FLNC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EIF3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ITPR3_HUMAN | [view interactions] | High throughput | no | yes |
ITPR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VAMP3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RS15A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RS7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RS4X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TWF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NEXN_HUMAN | [view interactions] | High throughput | no | yes |
NSUN2_HUMAN | [view interactions] | High throughput | no | yes |
FLII_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TOP2B_HUMAN | [view interactions] | High throughput | no | yes |
PALS1_HUMAN | [view interactions] | High throughput | no | no |
LUZP1_HUMAN | [view interactions] | High throughput | no | yes |
PHLB2_HUMAN | [view interactions] | High throughput | no | yes |
RFLB_HUMAN | [view interactions] | High throughput | no | yes |
FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ACTBL_HUMAN | [view interactions] | High throughput | no | no |
CYTSB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AIF1L_HUMAN | [view interactions] | High throughput | no | yes |
UBN2_HUMAN | [view interactions] | High throughput | no | yes |
EIF3M_HUMAN | [view interactions] | High throughput | no | yes |
POTEE_HUMAN | [view interactions] | High throughput | no | no |
ACTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
E41L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PHAX_HUMAN | [view interactions] | High throughput | no | yes |
CSK21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ACTC_HUMAN | [view interactions] | High throughput | no | no |
GBF1_HUMAN | [view interactions] | High throughput | no | yes |
DC1I1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DC1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DC1L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DCTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BICD1_HUMAN | [view interactions] | High throughput | no | yes |
BICD2_HUMAN | [view interactions] | High throughput | no | yes |
SEC62_HUMAN | [view interactions] | High throughput | no | yes |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RADI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NAA40_HUMAN | [view interactions] | High throughput | no | no |
PML_HUMAN | [view interactions] | High throughput | no | yes |
ARRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LRCH3_HUMAN | [view interactions] | High throughput | no | yes |
OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
FL2D_HUMAN | [view interactions] | High throughput | no | yes |
MET14_HUMAN | [view interactions] | High throughput | no | yes |
RHGBA_HUMAN | [view interactions] | High throughput | no | yes |
DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
ESR1_HUMAN | [view interactions] | High throughput | no | no |
ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AXIN1_HUMAN | [view interactions] | High throughput | no | yes |
SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TPTE2_HUMAN | [view interactions] | High throughput | no | no |
BCL7A_HUMAN | [view interactions] | High throughput | no | yes |
TINF2_HUMAN | [view interactions] | High throughput | no | no |
AKT3_HUMAN | [view interactions] | High throughput | no | yes |
ATF3_HUMAN | [view interactions] | High throughput | no | yes |
VMP1_HUMAN | [view interactions] | High throughput | no | yes |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
JUN_HUMAN | [view interactions] | High throughput | no | yes |
BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
LITD1_HUMAN | [view interactions] | High throughput | no | no |
EGLN_HUMAN | [view interactions] | High throughput | no | no |
RYBP_HUMAN | [view interactions] | High throughput | no | no |
HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CUL1_HUMAN | [view interactions] | High throughput | no | yes |
CSN5_HUMAN | [view interactions] | High throughput | no | yes |
CUL2_HUMAN | [view interactions] | High throughput | no | yes |
NEDD8_HUMAN | [view interactions] | High throughput | no | yes |
CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CUL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TERF1_HUMAN | [view interactions] | High throughput | no | no |
POTE1_HUMAN | [view interactions] | High throughput | no | no |
RON_HUMAN | [view interactions] | High throughput | no | yes |
QKI_HUMAN | [view interactions] | High throughput | no | no |
LBR_HUMAN | [view interactions] | High throughput | no | yes |
RFOX2_HUMAN | [view interactions] | High throughput | no | yes |
TERF2_HUMAN | [view interactions] | High throughput | no | yes |
POC1B_HUMAN | [view interactions] | High throughput | no | no |
LIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SAS6_HUMAN | [view interactions] | High throughput | no | no |
CEP76_HUMAN | [view interactions] | High throughput | no | yes |
ISG15_HUMAN | [view interactions] | High throughput | no | no |
PAN2_HUMAN | [view interactions] | High throughput | no | no |
RFA3_HUMAN | [view interactions] | High throughput | no | yes |
RFA2_HUMAN | [view interactions] | High throughput | no | yes |
RFA1_HUMAN | [view interactions] | High throughput | no | yes |
P53_HUMAN | [view interactions] | High throughput | no | no |
CUL7_HUMAN | [view interactions] | High throughput | no | yes |
OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
LUZP4_HUMAN | [view interactions] | High throughput | no | no |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
KIF11_HUMAN | [view interactions] | High throughput | no | yes |
MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NFM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TM9S4_HUMAN | [view interactions] | High throughput | no | yes |
TACC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GPSM2_HUMAN | [view interactions] | High throughput | no | yes |
LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FIGL1_HUMAN | [view interactions] | High throughput | no | yes |
MYO19_HUMAN | [view interactions] | High throughput | no | yes |
KIF4A_HUMAN | [view interactions] | High throughput | no | yes |
KIF4B_HUMAN | [view interactions] | High throughput | no | no |
PLK2_HUMAN | [view interactions] | High throughput | no | yes |
TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TES_HUMAN | [view interactions] | High throughput | no | yes |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
KPCD2_HUMAN | [view interactions] | High throughput | no | yes |
DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
DOCK8_HUMAN | [view interactions] | High throughput | no | yes |
SYDE2_HUMAN | [view interactions] | High throughput | no | no |
NUPR1_HUMAN | [view interactions] | High throughput | no | no |
1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NUDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BTF3_HUMAN | [view interactions] | High throughput | no | yes |
FGD5_HUMAN | [view interactions] | High throughput | no | yes |
SIK2_HUMAN | [view interactions] | High throughput | no | yes |
FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AP2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FLNB_HUMAN | [view interactions] | High throughput | no | no |
RLA0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RLA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AT1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
OAT_HUMAN | [view interactions] | High throughput | no | yes |
VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ANXA6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TFR1_HUMAN | [view interactions] | High throughput | no | yes |
SVIL_HUMAN | [view interactions] | High throughput | no | yes |
LDHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SAP18_HUMAN | [view interactions] | High throughput | no | yes |
AAAT_HUMAN | [view interactions] | High throughput | no | no |
SI1L3_HUMAN | [view interactions] | High throughput | no | yes |
DAPK3_HUMAN | [view interactions] | High throughput | no | yes |
STRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARPC5_HUMAN | [view interactions] | High throughput | no | yes |
SPTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYPT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARPC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARPC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARC1B_HUMAN | [view interactions] | High throughput | no | no |
CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL28_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ARP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HIRA_HUMAN | [view interactions] | High throughput | no | yes |
ANX11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAZA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
QCR7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MTDC_HUMAN | [view interactions] | High throughput | no | yes |
TPR_HUMAN | [view interactions] | High throughput | no | yes |
AL1B1_HUMAN | [view interactions] | High throughput | no | yes |
LMOD1_HUMAN | [view interactions] | High throughput | no | no |
VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TMOD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CING_HUMAN | [view interactions] | High throughput | no | no |
EIF3H_HUMAN | [view interactions] | High throughput | no | yes |
NH2L1_HUMAN | [view interactions] | High throughput | no | yes |
MPRIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LMAN2_HUMAN | [view interactions] | High throughput | no | yes |
CYTSA_HUMAN | [view interactions] | High throughput | no | yes |
SRGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
F107B_HUMAN | [view interactions] | High throughput | no | no |
ZO1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
INF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SPTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MTFR1_HUMAN | [view interactions] | High throughput | no | yes |
LAMB1_HUMAN | [view interactions] | High throughput | no | yes |
ARPC4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PEAK1_HUMAN | [view interactions] | High throughput | no | yes |
MYO1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ITPI2_HUMAN | [view interactions] | High throughput | no | yes |
MYL9_HUMAN | [view interactions] | Computational | no | no |
MK03_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GRB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
TPM2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MYLK_HUMAN | [view interactions] | Computational | no | no |
VINC_HUMAN | [view entry] [view interactions] | Computational | yes | no |
MK01_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ACTH_HUMAN | [view interactions] | Computational | no | no |
MYH11_HUMAN | [view entry] [view interactions] | Computational | yes | no |