Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CALD1_HUMAN

GO
G2C
SynaptomeDB

Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration . [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in CALD1_HUMAN
GO:0003779 actin binding 35.2000 4 yes
GO:0000166 nucleotide binding 27.2000 4 no
GO:0003723 RNA binding 26.4000 4 no
GO:0017076 purine nucleotide binding 25.6000 5 no
GO:0043168 anion binding 25.6000 4 no
GO:0030554 adenyl nucleotide binding 23.2000 6 no
GO:0032555 purine ribonucleotide binding 23.2000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 23.2000 4 no
GO:0045296 cadherin binding 20.8000 4 yes
GO:0005524 ATP binding 20.8000 5 no
GO:0032559 adenyl ribonucleotide binding 20.8000 5 no
GO:0005523 tropomyosin binding 1.6000 4 yes
GO:0017022 myosin binding 1.6000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CALD1_HUMAN
GO:0048522 positive regulation of cellular process 49.6000 4 no
GO:0051128 regulation of cellular component organization 45.6000 4 no
GO:0048523 negative regulation of cellular process 44.8000 4 no
GO:0031323 regulation of cellular metabolic process 43.2000 4 no
GO:0060255 regulation of macromolecule metabolic process 42.4000 4 no
GO:0006996 organelle organization 40.0000 4 no
GO:0080090 regulation of primary metabolic process 39.2000 4 no
GO:0022607 cellular component assembly 34.4000 4 yes
GO:0009889 regulation of biosynthetic process 33.6000 4 no
GO:0031326 regulation of cellular biosynthetic process 33.6000 5 no
GO:0010646 regulation of cell communication 32.8000 4 no
GO:0010468 regulation of gene expression 32.8000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 32.8000 5 no
GO:0007010 cytoskeleton organization 32.0000 5 no
GO:0009893 positive regulation of metabolic process 31.2000 4 no
GO:0009966 regulation of signal transduction 29.6000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 29.6000 5 no
GO:0033043 regulation of organelle organization 29.6000 5 no
GO:0044087 regulation of cellular component biogenesis 29.6000 4 no
GO:0051246 regulation of protein metabolic process 28.8000 5 no
GO:0097435 supramolecular fiber organization 27.2000 4 yes
GO:0031325 positive regulation of cellular metabolic process 26.4000 5 no
GO:0008104 protein localization 25.6000 4 no
GO:0048584 positive regulation of response to stimulus 23.2000 4 no
GO:1902531 regulation of intracellular signal transduction 23.2000 5 no
GO:0051049 regulation of transport 23.2000 4 no
GO:0007015 actin filament organization 22.4000 5 yes
GO:0023056 positive regulation of signaling 21.6000 4 no
GO:0009891 positive regulation of biosynthetic process 21.6000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.6000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 21.6000 6 no
GO:0060341 regulation of cellular localization 21.6000 4 no
GO:0071310 cellular response to organic substance 21.6000 4 no
GO:0009892 negative regulation of metabolic process 20.8000 4 no
GO:0010647 positive regulation of cell communication 20.8000 5 no
GO:0051493 regulation of cytoskeleton organization 20.8000 6 no
GO:0051017 actin filament bundle assembly 5.6000 5 yes
GO:0061572 actin filament bundle organization 5.6000 6 yes
GO:0006936 muscle contraction 4.0000 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CALM2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
KAPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
CDK1_HUMAN [view interactions] Low throughput no no
MK03_HUMAN [view entry] [view interactions] Low throughput yes yes
SHC1_HUMAN [view entry] [view interactions] Low throughput yes yes
RLA1_HUMAN [view entry] [view interactions] High throughput yes no
AT1A1_HUMAN [view entry] [view interactions] High throughput yes no
OAT_HUMAN [view interactions] High throughput no yes
VIME_HUMAN [view entry] [view interactions] High throughput yes no
ANXA6_HUMAN [view entry] [view interactions] High throughput yes yes
TFR1_HUMAN [view entry] [view interactions] High throughput yes yes
SVIL_HUMAN [view interactions] High throughput no yes
LDHA_HUMAN [view entry] [view interactions] High throughput yes yes
SAP18_HUMAN [view interactions] High throughput no yes
AAAT_HUMAN [view interactions] High throughput no no
SI1L3_HUMAN [view entry] [view interactions] High throughput yes yes
DAPK3_HUMAN [view interactions] High throughput no yes
STRN_HUMAN [view entry] [view interactions] High throughput yes yes
ACTN4_HUMAN [view entry] [view interactions] High throughput yes yes
ARPC5_HUMAN [view entry] [view interactions] High throughput yes yes
SPTN2_HUMAN [view entry] [view interactions] High throughput yes yes
MYPT1_HUMAN [view entry] [view interactions] High throughput yes yes
ARPC3_HUMAN [view entry] [view interactions] High throughput yes yes
ARPC2_HUMAN [view entry] [view interactions] High throughput yes yes
ARC1B_HUMAN [view interactions] High throughput no no
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
RL28_HUMAN [view entry] [view interactions] High throughput yes yes
RL22_HUMAN [view entry] [view interactions] High throughput yes no
ARP3_HUMAN [view entry] [view interactions] High throughput yes yes
HIRA_HUMAN [view interactions] High throughput no yes
ANX11_HUMAN [view entry] [view interactions] High throughput yes yes
CAZA1_HUMAN [view entry] [view interactions] High throughput yes yes
QCR7_HUMAN [view entry] [view interactions] High throughput yes yes
MTDC_HUMAN [view interactions] High throughput no yes
TPR_HUMAN [view interactions] High throughput no yes
AL1B1_HUMAN [view interactions] High throughput no yes
LMOD1_HUMAN [view interactions] High throughput no no
VDAC1_HUMAN [view entry] [view interactions] High throughput yes yes
TMOD1_HUMAN [view entry] [view interactions] High throughput yes yes
ARP2_HUMAN [view entry] [view interactions] High throughput yes yes
CING_HUMAN [view interactions] High throughput no no
EIF3H_HUMAN [view interactions] High throughput no yes
NH2L1_HUMAN [view interactions] High throughput no yes
MPRIP_HUMAN [view entry] [view interactions] High throughput yes yes
LMAN2_HUMAN [view interactions] High throughput no yes
CYTSA_HUMAN [view interactions] High throughput no yes
SRGP2_HUMAN [view entry] [view interactions] High throughput yes no
F107B_HUMAN [view interactions] High throughput no no
ZO1_HUMAN [view entry] [view interactions] High throughput yes no
INF2_HUMAN [view entry] [view interactions] High throughput yes yes
SPTB2_HUMAN [view entry] [view interactions] High throughput yes yes
MY18A_HUMAN [view entry] [view interactions] High throughput yes yes
MTFR1_HUMAN [view interactions] High throughput no yes
LAMB1_HUMAN [view interactions] High throughput no yes
ARPC4_HUMAN [view entry] [view interactions] High throughput yes no
PEAK1_HUMAN [view interactions] High throughput no yes
MYO1B_HUMAN [view entry] [view interactions] High throughput yes no
ITPI2_HUMAN [view interactions] High throughput no yes
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
PP1G_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA3_HUMAN [view interactions] High throughput no yes
EFHD1_HUMAN [view interactions] High throughput no no
K1671_HUMAN [view interactions] High throughput no yes
ARP5L_HUMAN [view entry] [view interactions] High throughput yes yes
F162A_HUMAN [view interactions] High throughput no yes
ARC1A_HUMAN [view entry] [view interactions] High throughput yes yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
PRR11_HUMAN [view interactions] High throughput no no
LRCH1_HUMAN [view interactions] High throughput no yes
ASF1A_HUMAN [view interactions] High throughput no no
NEB1_HUMAN [view entry] [view interactions] High throughput yes yes
CABIN_HUMAN [view interactions] High throughput no yes
MYO5C_HUMAN [view entry] [view interactions] High throughput yes yes
SYIM_HUMAN [view entry] [view interactions] High throughput yes yes
ZO2_HUMAN [view entry] [view interactions] High throughput yes no
DBNL_HUMAN [view entry] [view interactions] High throughput yes yes
CNOT2_HUMAN [view interactions] High throughput no yes
TMOD3_HUMAN [view interactions] High throughput no yes
RAI14_HUMAN [view interactions] High throughput no yes
ARP3B_HUMAN [view entry] [view interactions] High throughput yes yes
ITPR2_HUMAN [view interactions] High throughput no yes
FLNC_HUMAN [view entry] [view interactions] High throughput yes no
SRC8_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3A_HUMAN [view entry] [view interactions] High throughput yes yes
ITPR3_HUMAN [view interactions] High throughput no yes
ITPR1_HUMAN [view entry] [view interactions] High throughput yes yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
VAMP3_HUMAN [view entry] [view interactions] High throughput yes no
RS15A_HUMAN [view entry] [view interactions] High throughput yes yes
PP1B_HUMAN [view entry] [view interactions] High throughput yes yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
RS7_HUMAN [view entry] [view interactions] High throughput yes yes
RS4X_HUMAN [view entry] [view interactions] High throughput yes yes
TWF1_HUMAN [view entry] [view interactions] High throughput yes no
NEXN_HUMAN [view interactions] High throughput no yes
NSUN2_HUMAN [view interactions] High throughput no yes
FLII_HUMAN [view entry] [view interactions] High throughput yes yes
TRAP1_HUMAN [view entry] [view interactions] High throughput yes yes
TOP2B_HUMAN [view interactions] High throughput no yes
PALS1_HUMAN [view interactions] High throughput no no
LUZP1_HUMAN [view interactions] High throughput no yes
PHLB2_HUMAN [view interactions] High throughput no yes
RFLB_HUMAN [view interactions] High throughput no yes
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
ACTBL_HUMAN [view interactions] High throughput no no
CYTSB_HUMAN [view entry] [view interactions] High throughput yes yes
AIF1L_HUMAN [view interactions] High throughput no yes
UBN2_HUMAN [view interactions] High throughput no yes
EIF3M_HUMAN [view interactions] High throughput no yes
POTEE_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC6_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
EGFR_HUMAN [view interactions] High throughput no no
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
RN207_HUMAN [view interactions] High throughput no no
RICTR_HUMAN [view interactions] High throughput no yes
SMC5_HUMAN [view interactions] High throughput no yes
TNIP1_HUMAN [view interactions] High throughput no yes
ACTN1_HUMAN [view entry] [view interactions] High throughput yes yes
E41L2_HUMAN [view entry] [view interactions] High throughput yes yes
FUMH_HUMAN [view entry] [view interactions] High throughput yes yes
PHAX_HUMAN [view interactions] High throughput no yes
CSK21_HUMAN [view entry] [view interactions] High throughput yes yes
G3P_HUMAN [view entry] [view interactions] High throughput yes yes
NDKA_HUMAN [view entry] [view interactions] High throughput yes yes
PUR6_HUMAN [view entry] [view interactions] High throughput yes yes
MOES_HUMAN [view entry] [view interactions] High throughput yes no
PDIA3_HUMAN [view entry] [view interactions] High throughput yes yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPM_HUMAN [view entry] [view interactions] High throughput yes yes
ACLY_HUMAN [view entry] [view interactions] High throughput yes yes
RBP56_HUMAN [view interactions] High throughput no yes
CYBP_HUMAN [view entry] [view interactions] High throughput yes yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
ACTC_HUMAN [view interactions] High throughput no no
GBF1_HUMAN [view interactions] High throughput no yes
DC1I1_HUMAN [view entry] [view interactions] High throughput yes yes
DC1L1_HUMAN [view entry] [view interactions] High throughput yes yes
DC1L2_HUMAN [view entry] [view interactions] High throughput yes yes
DCTN4_HUMAN [view entry] [view interactions] High throughput yes yes
BICD1_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
SEC62_HUMAN [view interactions] High throughput no yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
RADI_HUMAN [view entry] [view interactions] High throughput yes yes
NAA40_HUMAN [view interactions] High throughput no no
PML_HUMAN [view interactions] High throughput no yes
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
RAB18_HUMAN [view entry] [view interactions] High throughput yes yes
YAP1_HUMAN [view interactions] High throughput no yes
WWTR1_HUMAN [view interactions] High throughput no yes
ARRB1_HUMAN [view entry] [view interactions] High throughput yes yes
LRCH3_HUMAN [view interactions] High throughput no yes
OTUB1_HUMAN [view interactions] High throughput no yes
FL2D_HUMAN [view interactions] High throughput no yes
MET14_HUMAN [view interactions] High throughput no yes
RHGBA_HUMAN [view interactions] High throughput no yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
ZBT18_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
PK3CA_HUMAN [view entry] [view interactions] High throughput yes yes
RMC1_HUMAN [view interactions] High throughput no no
ODPA_HUMAN [view entry] [view interactions] High throughput yes yes
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
AXIN1_HUMAN [view interactions] High throughput no yes
SPTN1_HUMAN [view entry] [view interactions] High throughput yes yes
TPTE2_HUMAN [view interactions] High throughput no no
BCL7A_HUMAN [view interactions] High throughput no yes
TINF2_HUMAN [view interactions] High throughput no no
AKT3_HUMAN [view interactions] High throughput no yes
ATF3_HUMAN [view interactions] High throughput no yes
VMP1_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
JUN_HUMAN [view interactions] High throughput no yes
BCAR1_HUMAN [view interactions] High throughput no yes
LITD1_HUMAN [view interactions] High throughput no no
EGLN_HUMAN [view interactions] High throughput no no
RYBP_HUMAN [view interactions] High throughput no no
TMIG1_HUMAN [view interactions] High throughput no no
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes
CAND1_HUMAN [view entry] [view interactions] High throughput yes no
CUL1_HUMAN [view interactions] High throughput no yes
CSN5_HUMAN [view interactions] High throughput no yes
CUL2_HUMAN [view interactions] High throughput no yes
NEDD8_HUMAN [view entry] [view interactions] High throughput yes yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
CUL5_HUMAN [view entry] [view interactions] High throughput yes yes
TERF1_HUMAN [view interactions] High throughput no no
POTE1_HUMAN [view interactions] High throughput no no
RON_HUMAN [view interactions] High throughput no yes
QKI_HUMAN [view interactions] High throughput no no
LBR_HUMAN [view interactions] High throughput no yes
RFOX2_HUMAN [view interactions] High throughput no yes
TERF2_HUMAN [view interactions] High throughput no yes
POC1B_HUMAN [view interactions] High throughput no no
LIS1_HUMAN [view entry] [view interactions] High throughput yes yes
SAS6_HUMAN [view interactions] High throughput no no
CEP76_HUMAN [view interactions] High throughput no yes
ISG15_HUMAN [view interactions] High throughput no no
PAN2_HUMAN [view interactions] High throughput no no
RFA3_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
CUL7_HUMAN [view interactions] High throughput no yes
OBSL1_HUMAN [view interactions] High throughput no yes
LUZP4_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
KIF11_HUMAN [view interactions] High throughput no yes
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
NFM_HUMAN [view entry] [view interactions] High throughput yes yes
TM9S4_HUMAN [view interactions] High throughput no yes
TACC3_HUMAN [view entry] [view interactions] High throughput yes yes
GPSM2_HUMAN [view entry] [view interactions] High throughput yes yes
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
FIGL1_HUMAN [view interactions] High throughput no yes
MYO19_HUMAN [view interactions] High throughput no yes
KIF4A_HUMAN [view interactions] High throughput no yes
KIF4B_HUMAN [view interactions] High throughput no no
PLK2_HUMAN [view entry] [view interactions] High throughput yes yes
TPM1_HUMAN [view entry] [view interactions] High throughput yes no
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
TES_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
LAP2A_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
KPCD2_HUMAN [view interactions] High throughput no yes
DYR1A_HUMAN [view interactions] High throughput no yes
DOCK8_HUMAN [view interactions] High throughput no yes
SYDE2_HUMAN [view interactions] High throughput no no
NUPR1_HUMAN [view interactions] High throughput no no
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
NUDC2_HUMAN [view entry] [view interactions] High throughput yes yes
BTF3_HUMAN [view interactions] High throughput no yes
FGD5_HUMAN [view interactions] High throughput no yes
SIK2_HUMAN [view interactions] High throughput no yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
AP2A2_HUMAN [view entry] [view interactions] High throughput yes yes
FLNB_HUMAN [view interactions] High throughput no no
RLA0_HUMAN [view entry] [view interactions] High throughput yes yes