Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NEB1_HUMAN

Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May be involved in neurite formation. Inhibits protein phosphatase 1-alpha activity . [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in NEB1_HUMAN
GO:0000166 nucleotide binding 39.6226 4 no
GO:0017076 purine nucleotide binding 39.6226 5 no
GO:0032555 purine ribonucleotide binding 37.7358 4 no
GO:0043168 anion binding 37.7358 4 no
GO:0035639 purine ribonucleoside triphosphate binding 35.8491 4 no
GO:0003779 actin binding 28.3019 4 yes
GO:0043169 cation binding 26.4151 4 no
GO:0046872 metal ion binding 26.4151 5 no
GO:0019900 kinase binding 26.4151 4 no
GO:0019901 protein kinase binding 24.5283 5 no
GO:0003924 GTPase activity 20.7547 7 no
GO:0005525 GTP binding 20.7547 5 no
GO:0016462 pyrophosphatase activity 20.7547 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 20.7547 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 20.7547 6 no
GO:0019001 guanyl nucleotide binding 20.7547 6 no
GO:0032561 guanyl ribonucleotide binding 20.7547 5 no
GO:0045296 cadherin binding 20.7547 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in NEB1_HUMAN
GO:0048522 positive regulation of cellular process 64.1509 4 no
GO:0031323 regulation of cellular metabolic process 54.7170 4 no
GO:0048523 negative regulation of cellular process 54.7170 4 no
GO:0060255 regulation of macromolecule metabolic process 52.8302 4 no
GO:0051128 regulation of cellular component organization 50.9434 4 no
GO:0080090 regulation of primary metabolic process 47.1698 4 no
GO:0010646 regulation of cell communication 45.2830 4 yes
GO:0009893 positive regulation of metabolic process 39.6226 4 no
GO:0010604 positive regulation of macromolecule metabolic process 39.6226 5 no
GO:0051246 regulation of protein metabolic process 39.6226 5 no
GO:0008104 protein localization 37.7358 4 no
GO:0141124 intracellular signaling cassette 37.7358 4 yes
GO:0009889 regulation of biosynthetic process 37.7358 4 no
GO:0009966 regulation of signal transduction 37.7358 4 no
GO:0010468 regulation of gene expression 37.7358 6 no
GO:0010556 regulation of macromolecule biosynthetic process 37.7358 5 no
GO:0031326 regulation of cellular biosynthetic process 37.7358 5 no
GO:0007015 actin filament organization 33.9623 5 yes
GO:0030030 cell projection organization 33.9623 4 yes
GO:0097435 supramolecular fiber organization 33.9623 4 yes
GO:0031325 positive regulation of cellular metabolic process 33.9623 5 no
GO:0006996 organelle organization 33.9623 4 no
GO:0022607 cellular component assembly 33.9623 4 no
GO:0033043 regulation of organelle organization 32.0755 5 no
GO:0031399 regulation of protein modification process 30.1887 6 no
GO:0051049 regulation of transport 30.1887 4 no
GO:0044087 regulation of cellular component biogenesis 28.3019 4 no
GO:0051493 regulation of cytoskeleton organization 28.3019 6 no
GO:1902531 regulation of intracellular signal transduction 28.3019 5 no
GO:0031344 regulation of cell projection organization 28.3019 5 no
GO:0042127 regulation of cell population proliferation 28.3019 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 28.3019 6 no
GO:0120036 plasma membrane bounded cell projection organization 26.4151 5 yes
GO:0051094 positive regulation of developmental process 26.4151 4 no
GO:0048584 positive regulation of response to stimulus 26.4151 4 no
GO:0051247 positive regulation of protein metabolic process 26.4151 6 no
GO:0060341 regulation of cellular localization 24.5283 4 no
GO:0009892 negative regulation of metabolic process 24.5283 4 no
GO:0042981 regulation of apoptotic process 24.5283 5 no
GO:0043067 regulation of programmed cell death 24.5283 4 no
GO:0051240 positive regulation of multicellular organismal process 24.5283 4 no
GO:0001932 regulation of protein phosphorylation 24.5283 7 no
GO:0019220 regulation of phosphate metabolic process 24.5283 6 no
GO:0030334 regulation of cell migration 24.5283 5 no
GO:0042325 regulation of phosphorylation 24.5283 7 no
GO:0051174 regulation of phosphorus metabolic process 24.5283 5 no
GO:0071310 cellular response to organic substance 24.5283 4 no
GO:2000145 regulation of cell motility 24.5283 4 no
GO:0051726 regulation of cell cycle 24.5283 4 no
GO:0007010 cytoskeleton organization 24.5283 5 no
GO:0010605 negative regulation of macromolecule metabolic process 22.6415 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 22.6415 5 no
GO:0051130 positive regulation of cellular component organization 22.6415 5 no
GO:0022603 regulation of anatomical structure morphogenesis 22.6415 4 no
GO:0032956 regulation of actin cytoskeleton organization 22.6415 5 no
GO:0032970 regulation of actin filament-based process 22.6415 4 no
GO:1902903 regulation of supramolecular fiber organization 20.7547 5 no
GO:0032880 regulation of protein localization 20.7547 5 no
GO:0045595 regulation of cell differentiation 20.7547 4 no
GO:0008284 positive regulation of cell population proliferation 20.7547 5 no
GO:0009967 positive regulation of signal transduction 20.7547 5 no
GO:0010647 positive regulation of cell communication 20.7547 5 no
GO:0023056 positive regulation of signaling 20.7547 4 no
GO:0030155 regulation of cell adhesion 20.7547 4 no
GO:0031324 negative regulation of cellular metabolic process 20.7547 5 no
GO:0031401 positive regulation of protein modification process 20.7547 7 no
GO:1901701 cellular response to oxygen-containing compound 20.7547 4 no
GO:0031175 neuron projection development 18.8679 6 yes
GO:0050804 modulation of chemical synaptic transmission 13.2075 5 yes
GO:0099177 regulation of trans-synaptic signaling 13.2075 4 yes
GO:0019722 calcium-mediated signaling 11.3208 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ARHG2_HUMAN [view entry] [view interactions] Low throughput yes yes
NEB1_HUMAN [view entry] [view interactions] Low throughput yes yes
KS6B1_HUMAN [view entry] [view interactions] Low throughput yes yes
PP1G_HUMAN [view entry] [view interactions] Low throughput yes yes
PP1B_HUMAN [view entry] [view interactions] Low throughput yes yes
PP1A_HUMAN [view entry] [view interactions] Low throughput yes yes
RGS2_HUMAN [view interactions] Low throughput no no
RAC3_HUMAN [view entry] [view interactions] Low throughput yes no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
AFAD_HUMAN [view entry] [view interactions] High throughput yes yes
OCLN_HUMAN [view interactions] High throughput no no
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RADI_HUMAN [view entry] [view interactions] High throughput yes yes
WDR48_HUMAN [view entry] [view interactions] High throughput yes yes
MYO19_HUMAN [view interactions] High throughput no yes
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
LRP8_HUMAN [view entry] [view interactions] High throughput yes no
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
CASQ2_HUMAN [view interactions] High throughput no no
NEXN_HUMAN [view interactions] High throughput no yes
IKBA_HUMAN [view interactions] High throughput no yes
B2L12_HUMAN [view interactions] High throughput no yes
MYO6_HUMAN [view entry] [view interactions] High throughput yes no
CING_HUMAN [view interactions] High throughput no no
RASF2_HUMAN [view interactions] High throughput no yes
RCN1_HUMAN [view interactions] High throughput no yes
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
PRG2_HUMAN [view interactions] High throughput no no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
DCLK1_HUMAN [view entry] [view interactions] High throughput yes yes
DCLK2_HUMAN [view entry] [view interactions] High throughput yes yes
TBCK_HUMAN [view interactions] High throughput no yes
HASP_HUMAN [view interactions] High throughput no yes
NUAK2_HUMAN [view interactions] High throughput no yes
AAPK1_HUMAN [view interactions] High throughput no no
MYCB2_HUMAN [view entry] [view interactions] High throughput yes no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
ITM2B_HUMAN [view interactions] High throughput no yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CEP63_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
ANR28_HUMAN [view interactions] High throughput no no
CTDSL_HUMAN [view interactions] High throughput no no
LMTK1_HUMAN [view interactions] High throughput no yes
LMTK3_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
KCNK3_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
CCDC8_HUMAN [view interactions] High throughput no yes
KCD17_HUMAN [view interactions] High throughput no yes
PPR3A_HUMAN [view interactions] High throughput no no
MD2L1_HUMAN [view interactions] High throughput no no
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
APC15_HUMAN [view interactions] High throughput no yes
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
LG3BP_HUMAN [view interactions] High throughput no no
CCSE2_HUMAN [view interactions] High throughput no yes
FBX21_HUMAN [view interactions] High throughput no yes
SPIR2_HUMAN [view interactions] High throughput no yes
MYL6_HUMAN [view entry] [view interactions] High throughput yes no
SG2A2_HUMAN [view interactions] High throughput no no
IQCN_HUMAN [view interactions] High throughput no no
ATF6B_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
ANLN_HUMAN [view interactions] High throughput no yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
CHM4C_HUMAN [view interactions] High throughput no yes
ECT2_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
PRC1_HUMAN [view interactions] High throughput no yes
MUCEN_HUMAN [view interactions] High throughput no yes
MTMRA_HUMAN [view interactions] High throughput no yes
KC1AL_HUMAN [view interactions] High throughput no no
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
IF16_HUMAN [view interactions] High throughput no no
OTUB2_HUMAN [view interactions] High throughput no no
IL13_HUMAN [view interactions] High throughput no no
DYLT5_HUMAN [view interactions] High throughput no no
RL23_HUMAN [view entry] [view interactions] High throughput yes yes
CC036_HUMAN [view interactions] High throughput no no
EMB_HUMAN [view interactions] High throughput no no
PLAT4_HUMAN [view interactions] High throughput no no
NXT1_HUMAN [view interactions] High throughput no no
JPH3_HUMAN [view interactions] High throughput no no
SAA1_HUMAN [view interactions] High throughput no no
ARM10_HUMAN [view entry] [view interactions] High throughput yes yes
CRGD_HUMAN [view interactions] High throughput no no
TP4A3_HUMAN [view interactions] High throughput no no
S39A3_HUMAN [view interactions] High throughput no yes
AHNK_HUMAN [view entry] [view interactions] High throughput yes yes
RPC9_HUMAN [view interactions] High throughput no yes
TM147_HUMAN [view interactions] High throughput no no
RM02_HUMAN [view interactions] High throughput no yes
TPX2_HUMAN [view interactions] High throughput no yes
TOP3B_HUMAN [view interactions] High throughput no no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOF_HUMAN [view interactions] High throughput no no
RND3_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
RHOD_HUMAN [view interactions] High throughput no no
CALD1_HUMAN [view entry] [view interactions] High throughput yes no
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
SRC8_HUMAN [view entry] [view interactions] High throughput yes yes
RPAC2_HUMAN [view interactions] High throughput no no
ZRAN1_HUMAN [view interactions] High throughput no yes
GCSP_HUMAN [view interactions] High throughput no yes
TNIP1_HUMAN [view interactions] High throughput no yes
KS6A1_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
CAV1_HUMAN [view interactions] High throughput no no
CXAR_HUMAN [view interactions] High throughput no yes
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes