NEB1_HUMAN
Evidence for PS localization
Functions
Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May be involved in neurite formation. Inhibits protein phosphatase 1-alpha activity . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NEB1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 39.1304 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 39.1304 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 39.1304 | 4 | no |
| GO:0019900 | kinase binding | 32.6087 | 4 | no |
| GO:0003779 | actin binding | 30.4348 | 4 | yes |
| GO:0019901 | protein kinase binding | 30.4348 | 5 | no |
| GO:0046872 | metal ion binding | 23.9130 | 4 | no |
| GO:0003924 | GTPase activity | 23.9130 | 7 | no |
| GO:0005525 | GTP binding | 23.9130 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 23.9130 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 23.9130 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 23.9130 | 6 | no |
| GO:0019001 | guanyl nucleotide binding | 23.9130 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 23.9130 | 5 | no |
| GO:0045296 | cadherin binding | 21.7391 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NEB1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 63.0435 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 56.5217 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 54.3478 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 54.3478 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 52.1739 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 50.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 47.8261 | 4 | no |
| GO:0010646 | regulation of cell communication | 45.6522 | 4 | yes |
| GO:0006996 | organelle organization | 43.4783 | 4 | no |
| GO:0007015 | actin filament organization | 41.3043 | 5 | yes |
| GO:0030030 | cell projection organization | 41.3043 | 4 | yes |
| GO:0097435 | supramolecular fiber organization | 41.3043 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 41.3043 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 41.3043 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 41.3043 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 39.1304 | 5 | no |
| GO:0010468 | regulation of gene expression | 36.9565 | 5 | no |
| GO:0009966 | regulation of signal transduction | 36.9565 | 4 | no |
| GO:0033043 | regulation of organelle organization | 36.9565 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 34.7826 | 6 | no |
| GO:0022607 | cellular component assembly | 34.7826 | 4 | no |
| GO:0051049 | regulation of transport | 32.6087 | 4 | no |
| GO:0008104 | protein localization | 32.6087 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 32.6087 | 5 | no |
| GO:0031399 | regulation of protein modification process | 32.6087 | 6 | no |
| GO:0007010 | cytoskeleton organization | 32.6087 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 30.4348 | 5 | yes |
| GO:0042127 | regulation of cell population proliferation | 30.4348 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.4348 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 30.4348 | 4 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 30.4348 | 5 | no |
| GO:0032970 | regulation of actin filament-based process | 30.4348 | 4 | no |
| GO:0036211 | protein modification process | 28.2609 | 4 | no |
| GO:0043412 | macromolecule modification | 28.2609 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 28.2609 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 28.2609 | 4 | no |
| GO:0051726 | regulation of cell cycle | 28.2609 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 28.2609 | 5 | no |
| GO:0010941 | regulation of cell death | 28.2609 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 28.2609 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 28.2609 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 28.2609 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 28.2609 | 4 | no |
| GO:0022604 | regulation of cell morphogenesis | 28.2609 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 26.0870 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 26.0870 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.0870 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 26.0870 | 5 | no |
| GO:0071702 | organic substance transport | 26.0870 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 26.0870 | 4 | no |
| GO:0071310 | cellular response to organic substance | 26.0870 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 26.0870 | 7 | no |
| GO:0042981 | regulation of apoptotic process | 26.0870 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 26.0870 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 26.0870 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 26.0870 | 6 | no |
| GO:0045595 | regulation of cell differentiation | 23.9130 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 23.9130 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 23.9130 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 23.9130 | 7 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 23.9130 | 5 | no |
| GO:0031175 | neuron projection development | 21.7391 | 6 | yes |
| GO:0008284 | positive regulation of cell population proliferation | 21.7391 | 5 | no |
| GO:0060341 | regulation of cellular localization | 21.7391 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.7391 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 21.7391 | 4 | no |
| GO:0051338 | regulation of transferase activity | 21.7391 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 21.7391 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 21.7391 | 6 | no |
| GO:0030334 | regulation of cell migration | 21.7391 | 5 | no |
| GO:0042327 | positive regulation of phosphorylation | 21.7391 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 21.7391 | 7 | no |
| GO:0051129 | negative regulation of cellular component organization | 21.7391 | 5 | no |
| GO:2000145 | regulation of cell motility | 21.7391 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.7391 | 5 | no |
| GO:0032535 | regulation of cellular component size | 21.7391 | 4 | no |
| GO:0110053 | regulation of actin filament organization | 21.7391 | 6 | no |
| GO:0007264 | small GTPase mediated signal transduction | 21.7391 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 15.2174 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 15.2174 | 4 | yes |
| GO:0019722 | calcium-mediated signaling | 13.0435 | 5 | yes |
| GO:0019932 | second-messenger-mediated signaling | 13.0435 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in NEB1_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 4.3478 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 4.3478 | 5 | no |
| DOID:114 | heart disease | 4.3478 | 3 | no |
| DOID:2843 | long QT syndrome | 4.3478 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RGS2_HUMAN | [view interactions] | Low throughput | no | no |
| RAC3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ARHG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NEB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KS6B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PP1G_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PP1B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PP1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NEXN_HUMAN | [view interactions] | High throughput | no | yes |
| IKBA_HUMAN | [view interactions] | High throughput | no | yes |
| B2L12_HUMAN | [view interactions] | High throughput | no | yes |
| MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CING_HUMAN | [view interactions] | High throughput | no | no |
| RASF2_HUMAN | [view interactions] | High throughput | no | yes |
| RCN1_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRG2_HUMAN | [view interactions] | High throughput | no | no |
| DCLK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCLK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBCK_HUMAN | [view interactions] | High throughput | no | yes |
| HASP_HUMAN | [view interactions] | High throughput | no | yes |
| NUAK2_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| ANR28_HUMAN | [view interactions] | High throughput | no | no |
| CTDSL_HUMAN | [view interactions] | High throughput | no | no |
| LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
| LMTK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| KCD17_HUMAN | [view interactions] | High throughput | no | yes |
| PPR3A_HUMAN | [view interactions] | High throughput | no | no |
| MD2L1_HUMAN | [view interactions] | High throughput | no | no |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| APC15_HUMAN | [view interactions] | High throughput | no | yes |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LG3BP_HUMAN | [view interactions] | High throughput | no | no |
| CCSE2_HUMAN | [view interactions] | High throughput | no | yes |
| FBX21_HUMAN | [view interactions] | High throughput | no | yes |
| SPIR2_HUMAN | [view interactions] | High throughput | no | yes |
| MYL6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SG2A2_HUMAN | [view interactions] | High throughput | no | no |
| IQCN_HUMAN | [view interactions] | High throughput | no | no |
| ATF6B_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| MUCEN_HUMAN | [view interactions] | High throughput | no | yes |
| MTMRA_HUMAN | [view interactions] | High throughput | no | yes |
| KC1AL_HUMAN | [view interactions] | High throughput | no | no |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF16_HUMAN | [view interactions] | High throughput | no | no |
| OTUB2_HUMAN | [view interactions] | High throughput | no | no |
| IL13_HUMAN | [view interactions] | High throughput | no | no |
| DYLT5_HUMAN | [view interactions] | High throughput | no | no |
| RL23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CC036_HUMAN | [view interactions] | High throughput | no | no |
| EMB_HUMAN | [view interactions] | High throughput | no | no |
| PLAT4_HUMAN | [view interactions] | High throughput | no | no |
| NXT1_HUMAN | [view interactions] | High throughput | no | no |
| JPH3_HUMAN | [view interactions] | High throughput | no | no |
| SAA1_HUMAN | [view interactions] | High throughput | no | no |
| ARM10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRGD_HUMAN | [view interactions] | High throughput | no | no |
| TP4A3_HUMAN | [view interactions] | High throughput | no | no |
| S39A3_HUMAN | [view interactions] | High throughput | no | yes |
| AHNK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPC9_HUMAN | [view interactions] | High throughput | no | yes |
| TM147_HUMAN | [view interactions] | High throughput | no | no |
| RM02_HUMAN | [view interactions] | High throughput | no | yes |
| TPX2_HUMAN | [view interactions] | High throughput | no | yes |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPAC2_HUMAN | [view interactions] | High throughput | no | no |
| KS6A1_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AFAD_HUMAN | [view interactions] | High throughput | no | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RADI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR48_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRP8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CASQ2_HUMAN | [view interactions] | High throughput | no | no |
| SGCE_HUMAN | [view interactions] | Computational | no | no |