DCLK1_HUMAN
Evidence for PS localization
Functions
Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DCLK1_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 29.7872 | 4 | no |
| GO:0046872 | metal ion binding | 27.6596 | 5 | no |
| GO:0019900 | kinase binding | 25.5319 | 4 | no |
| GO:0019901 | protein kinase binding | 23.4043 | 5 | no |
| GO:0030695 | GTPase regulator activity | 23.4043 | 4 | no |
| GO:0043168 | anion binding | 21.2766 | 4 | yes |
| GO:0003779 | actin binding | 21.2766 | 4 | no |
| GO:0000166 | nucleotide binding | 17.0213 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 17.0213 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 17.0213 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 17.0213 | 4 | yes |
| GO:0005524 | ATP binding | 14.8936 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 14.8936 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 14.8936 | 5 | yes |
| GO:0016301 | kinase activity | 12.7660 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 12.7660 | 4 | yes |
| GO:0004674 | protein serine/threonine kinase activity | 10.6383 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 10.6383 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DCLK1_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 57.4468 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 57.4468 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 55.3191 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 55.3191 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 51.0638 | 4 | yes |
| GO:0010646 | regulation of cell communication | 51.0638 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 51.0638 | 4 | no |
| GO:0009966 | regulation of signal transduction | 46.8085 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 46.8085 | 5 | no |
| GO:0022607 | cellular component assembly | 42.5532 | 4 | no |
| GO:0008104 | protein localization | 40.4255 | 4 | yes |
| GO:0031399 | regulation of protein modification process | 38.2979 | 6 | no |
| GO:0019220 | regulation of phosphate metabolic process | 36.1702 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 36.1702 | 5 | no |
| GO:0030030 | cell projection organization | 34.0426 | 4 | yes |
| GO:0006996 | organelle organization | 34.0426 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 34.0426 | 4 | no |
| GO:0010468 | regulation of gene expression | 34.0426 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 34.0426 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 34.0426 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 31.9149 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 31.9149 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 31.9149 | 7 | no |
| GO:1902531 | regulation of intracellular signal transduction | 31.9149 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 31.9149 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 31.9149 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 29.7872 | 7 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 29.7872 | 5 | no |
| GO:0141124 | intracellular signaling cassette | 29.7872 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 27.6596 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 27.6596 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 27.6596 | 5 | no |
| GO:0051049 | regulation of transport | 27.6596 | 4 | no |
| GO:0050807 | regulation of synapse organization | 27.6596 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.5319 | 4 | no |
| GO:0033043 | regulation of organelle organization | 25.5319 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 25.5319 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.5319 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 25.5319 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 25.5319 | 6 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 25.5319 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 25.5319 | 4 | no |
| GO:0032880 | regulation of protein localization | 23.4043 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 23.4043 | 4 | yes |
| GO:0010562 | positive regulation of phosphorus metabolic process | 23.4043 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 23.4043 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 23.4043 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 23.4043 | 7 | no |
| GO:0051130 | positive regulation of cellular component organization | 23.4043 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 21.2766 | 4 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 21.2766 | 8 | no |
| GO:0007010 | cytoskeleton organization | 21.2766 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 21.2766 | 5 | no |
| GO:0023056 | positive regulation of signaling | 21.2766 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 21.2766 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 21.2766 | 6 | no |
| GO:0043549 | regulation of kinase activity | 21.2766 | 5 | no |
| GO:0051338 | regulation of transferase activity | 21.2766 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 21.2766 | 6 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 21.2766 | 5 | no |
| GO:0010563 | negative regulation of phosphorus metabolic process | 21.2766 | 6 | no |
| GO:0031400 | negative regulation of protein modification process | 21.2766 | 7 | no |
| GO:0045936 | negative regulation of phosphate metabolic process | 21.2766 | 7 | no |
| GO:0034330 | cell junction organization | 21.2766 | 4 | no |
| GO:0036211 | protein modification process | 19.1489 | 4 | yes |
| GO:0043412 | macromolecule modification | 19.1489 | 4 | yes |
| GO:0048812 | neuron projection morphogenesis | 19.1489 | 5 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 19.1489 | 4 | yes |
| GO:0016310 | phosphorylation | 14.8936 | 5 | yes |
| GO:0033365 | protein localization to organelle | 14.8936 | 5 | yes |
| GO:0001764 | neuron migration | 12.7660 | 4 | yes |
| GO:0006468 | protein phosphorylation | 10.6383 | 5 | yes |
| GO:1903828 | negative regulation of protein localization | 10.6383 | 5 | yes |
| GO:0007399 | nervous system development | 8.5106 | 4 | yes |
| GO:0007409 | axonogenesis | 8.5106 | 6 | yes |
| GO:0007417 | central nervous system development | 8.5106 | 4 | yes |
| GO:0034504 | protein localization to nucleus | 8.5106 | 6 | yes |
| GO:1900180 | regulation of protein localization to nucleus | 8.5106 | 6 | yes |
| GO:1900181 | negative regulation of protein localization to nucleus | 8.5106 | 6 | yes |
| GO:1990138 | neuron projection extension | 8.5106 | 4 | yes |
| GO:0021952 | central nervous system projection neuron axonogenesis | 6.3830 | 8 | yes |
| GO:0021955 | central nervous system neuron axonogenesis | 6.3830 | 7 | yes |
| GO:0048675 | axon extension | 6.3830 | 5 | yes |
| GO:0048813 | dendrite morphogenesis | 4.2553 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| KLH15_HUMAN | [view interactions] | Low throughput | no | yes |
| DCX_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DCLK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 2AAB_HUMAN | [view interactions] | High throughput | no | yes |
| MCM7_HUMAN | [view interactions] | High throughput | no | no |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2ABA_HUMAN | [view interactions] | High throughput | no | yes |
| LRP2_HUMAN | [view interactions] | High throughput | no | no |
| TRIP6_HUMAN | [view interactions] | High throughput | no | yes |
| DDB1_HUMAN | [view interactions] | High throughput | no | yes |
| DCAF5_HUMAN | [view interactions] | High throughput | no | yes |
| FEM1C_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FEM1A_HUMAN | [view interactions] | High throughput | no | no |
| NEB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G3BP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3L_HUMAN | [view interactions] | High throughput | no | yes |
| ACK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTCS_HUMAN | [view interactions] | High throughput | no | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK5P2_HUMAN | [view interactions] | High throughput | no | yes |
| CEP63_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VP26C_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CE170_HUMAN | [view interactions] | High throughput | no | yes |
| CE128_HUMAN | [view interactions] | High throughput | no | yes |
| LCA5_HUMAN | [view interactions] | High throughput | no | no |
| SPICE_HUMAN | [view interactions] | High throughput | no | yes |
| MPIP3_HUMAN | [view interactions] | High throughput | no | yes |
| MAST3_HUMAN | [view interactions] | High throughput | no | yes |
| IF4E2_HUMAN | [view interactions] | High throughput | no | no |
| SRGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NADK_HUMAN | [view interactions] | High throughput | no | yes |
| NF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MPIP2_HUMAN | [view interactions] | High throughput | no | no |
| AFAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK16_HUMAN | [view interactions] | High throughput | no | yes |
| MELK_HUMAN | [view interactions] | High throughput | no | yes |
| TIAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| RAB3I_HUMAN | [view interactions] | High throughput | no | no |
| EDC3_HUMAN | [view interactions] | High throughput | no | yes |
| LPIN3_HUMAN | [view interactions] | High throughput | no | yes |
| RTKN_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INP5E_HUMAN | [view interactions] | High throughput | no | yes |
| FA53C_HUMAN | [view interactions] | High throughput | no | yes |
| LRFN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBP21_HUMAN | [view interactions] | High throughput | no | no |
| ZBT21_HUMAN | [view interactions] | High throughput | no | yes |
| PPM1H_HUMAN | [view interactions] | High throughput | no | yes |
| AGAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GAB2_HUMAN | [view interactions] | High throughput | no | yes |
| STA13_HUMAN | [view interactions] | High throughput | no | yes |
| KCTD3_HUMAN | [view interactions] | High throughput | no | yes |
| ZN638_HUMAN | [view interactions] | High throughput | no | yes |
| PTN14_HUMAN | [view interactions] | High throughput | no | yes |
| TBC25_HUMAN | [view interactions] | High throughput | no | yes |
| M3K21_HUMAN | [view interactions] | High throughput | no | yes |
| SPD2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DEN4C_HUMAN | [view interactions] | High throughput | no | yes |
| AN34A_HUMAN | [view interactions] | High throughput | no | no |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| LARP1_HUMAN | [view interactions] | High throughput | no | yes |
| MYCPP_HUMAN | [view interactions] | High throughput | no | no |
| PHLB2_HUMAN | [view interactions] | High throughput | no | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| DEN1A_HUMAN | [view interactions] | High throughput | no | no |
| SH3R3_HUMAN | [view interactions] | High throughput | no | yes |
| DEP1B_HUMAN | [view interactions] | High throughput | no | yes |
| SIN1_HUMAN | [view interactions] | High throughput | no | yes |
| SI1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF1C_HUMAN | [view interactions] | High throughput | no | yes |
| GGYF1_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| GGYF2_HUMAN | [view interactions] | High throughput | no | yes |
| SYDE1_HUMAN | [view interactions] | High throughput | no | yes |
| RPTOR_HUMAN | [view interactions] | High throughput | no | yes |
| NAV1_HUMAN | [view interactions] | High throughput | no | yes |
| F110B_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC7_HUMAN | [view interactions] | High throughput | no | no |
| SRS12_HUMAN | [view interactions] | High throughput | no | no |
| MAGI1_HUMAN | [view interactions] | High throughput | no | no |
| TESK2_HUMAN | [view interactions] | High throughput | no | yes |
| F110A_HUMAN | [view interactions] | High throughput | no | yes |
| KI13B_HUMAN | [view interactions] | High throughput | no | yes |
| SH3B4_HUMAN | [view interactions] | High throughput | no | yes |
| CING_HUMAN | [view interactions] | High throughput | no | no |
| NGAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBY1_HUMAN | [view interactions] | High throughput | no | no |
| CDC23_HUMAN | [view interactions] | High throughput | no | yes |
| EFHC2_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| BOREA_HUMAN | [view interactions] | High throughput | no | yes |
| DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CIC_HUMAN | [view interactions] | High throughput | no | yes |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FBLI1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NADAP_HUMAN | [view interactions] | High throughput | no | yes |
| ARHG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI36_HUMAN | [view interactions] | High throughput | no | no |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |