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GPM6A_HUMAN

GO
G2C
SynGO

Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in GPM6A_HUMAN
GO:0043168 anion binding 30.0000 4 no
GO:0043169 cation binding 26.3636 4 no
GO:0000166 nucleotide binding 25.4545 4 no
GO:0017076 purine nucleotide binding 25.4545 5 no
GO:0032555 purine ribonucleotide binding 25.4545 4 no
GO:0046872 metal ion binding 25.4545 5 no
GO:0035639 purine ribonucleoside triphosphate binding 23.6364 4 no
GO:0019900 kinase binding 20.9091 4 no
GO:0008324 monoatomic cation transmembrane transporter activity 13.6364 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 13.6364 4 yes
GO:0046873 metal ion transmembrane transporter activity 10.0000 5 yes
GO:0015267 channel activity 6.3636 4 yes
GO:0005216 monoatomic ion channel activity 5.4545 4 yes
GO:0015085 calcium ion transmembrane transporter activity 5.4545 6 yes
GO:0005261 monoatomic cation channel activity 4.5455 5 yes
GO:0005262 calcium channel activity 2.7273 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GPM6A_HUMAN
GO:0048522 positive regulation of cellular process 50.0000 4 yes
GO:0051128 regulation of cellular component organization 40.9091 4 yes
GO:0010646 regulation of cell communication 40.0000 4 no
GO:0051049 regulation of transport 39.0909 4 no
GO:0048523 negative regulation of cellular process 33.6364 4 no
GO:0022607 cellular component assembly 30.9091 4 yes
GO:0006996 organelle organization 30.9091 4 no
GO:0008104 protein localization 28.1818 4 no
GO:0060255 regulation of macromolecule metabolic process 27.2727 4 no
GO:0031323 regulation of cellular metabolic process 27.2727 4 no
GO:0050804 modulation of chemical synaptic transmission 26.3636 5 no
GO:0099177 regulation of trans-synaptic signaling 26.3636 4 no
GO:0051050 positive regulation of transport 24.5455 4 no
GO:0030030 cell projection organization 23.6364 4 yes
GO:0080090 regulation of primary metabolic process 23.6364 4 no
GO:0009966 regulation of signal transduction 23.6364 4 no
GO:0071702 organic substance transport 22.7273 4 no
GO:0071705 nitrogen compound transport 22.7273 4 no
GO:0010647 positive regulation of cell communication 21.8182 5 no
GO:0023056 positive regulation of signaling 21.8182 4 no
GO:0098657 import into cell 21.8182 4 no
GO:0051046 regulation of secretion 20.9091 5 no
GO:0031344 regulation of cell projection organization 20.0000 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 19.0909 6 yes
GO:0051130 positive regulation of cellular component organization 18.1818 5 yes
GO:0120036 plasma membrane bounded cell projection organization 18.1818 5 yes
GO:0044087 regulation of cellular component biogenesis 16.3636 4 yes
GO:0031175 neuron projection development 14.5455 6 yes
GO:0034330 cell junction organization 13.6364 4 yes
GO:0031346 positive regulation of cell projection organization 12.7273 6 yes
GO:0048812 neuron projection morphogenesis 10.9091 5 yes
GO:0050808 synapse organization 10.9091 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 10.9091 4 yes
GO:0050807 regulation of synapse organization 9.0909 5 yes
GO:0044089 positive regulation of cellular component biogenesis 7.2727 5 yes
GO:0034329 cell junction assembly 6.3636 5 yes
GO:0007416 synapse assembly 3.6364 6 yes
GO:0060491 regulation of cell projection assembly 3.6364 5 yes
GO:0120032 regulation of plasma membrane bounded cell projection assembly 3.6364 6 yes
GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 3.6364 6 yes
GO:0001764 neuron migration 2.7273 4 yes
GO:0051489 regulation of filopodium assembly 2.7273 7 yes
GO:0051491 positive regulation of filopodium assembly 2.7273 7 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
OPRM_HUMAN [view entry] [view interactions] Low throughput yes no
ZDH17_HUMAN [view entry] [view interactions] Low throughput yes yes
WLS_HUMAN [view entry] [view interactions] Low throughput yes no
TIM16_HUMAN [view entry] [view interactions] High throughput yes no
AGRG5_HUMAN [view interactions] High throughput no no
NUFP1_HUMAN [view interactions] High throughput no yes
P2RY1_HUMAN [view entry] [view interactions] High throughput yes yes
ARMC1_HUMAN [view interactions] High throughput no yes
TSN3_HUMAN [view interactions] High throughput no yes
MGT5A_HUMAN [view interactions] High throughput no yes
ERMP1_HUMAN [view interactions] High throughput no no
FITM2_HUMAN [view interactions] High throughput no no
CC126_HUMAN [view interactions] High throughput no yes
YIPF3_HUMAN [view interactions] High throughput no yes
FKRP_HUMAN [view interactions] High throughput no yes
ZDH18_HUMAN [view interactions] High throughput no yes
VNN2_HUMAN [view interactions] High throughput no no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
APBB1_HUMAN [view entry] [view interactions] High throughput yes yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
VAMP2_HUMAN [view entry] [view interactions] High throughput yes no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
TGFR2_HUMAN [view interactions] High throughput no no
ICAM5_HUMAN [view entry] [view interactions] High throughput yes yes
KLF11_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
RMD3_HUMAN [view entry] [view interactions] High throughput yes yes
S35B2_HUMAN [view interactions] High throughput no no
PLCC_HUMAN [view interactions] High throughput no no
HAX1_HUMAN [view interactions] High throughput no no
IKIP_HUMAN [view interactions] High throughput no no
RFT1_HUMAN [view interactions] High throughput no yes
QCR9_HUMAN [view interactions] High throughput no no
EREP3_HUMAN [view interactions] High throughput no no
SCAM2_HUMAN [view interactions] High throughput no no
PXMP2_HUMAN [view interactions] High throughput no no
GP1BB_HUMAN [view interactions] High throughput no no
VKORL_HUMAN [view interactions] High throughput no yes
KTU_HUMAN [view interactions] High throughput no yes
TSN17_HUMAN [view interactions] High throughput no yes
EDA_HUMAN [view interactions] High throughput no no
5HT3A_HUMAN [view entry] [view interactions] High throughput yes no
TRI25_HUMAN [view interactions] High throughput no yes
TADBP_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
H2AY_HUMAN [view interactions] High throughput no yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
EDIL3_HUMAN [view interactions] High throughput no yes
HPCL1_HUMAN [view interactions] High throughput no yes
DPYL5_HUMAN [view entry] [view interactions] High throughput yes yes
NCAM1_HUMAN [view entry] [view interactions] High throughput yes no
RAB3C_HUMAN [view entry] [view interactions] High throughput yes yes
E41L1_HUMAN [view entry] [view interactions] High throughput yes yes
CANB1_HUMAN [view entry] [view interactions] High throughput yes yes
DOXA2_HUMAN [view interactions] High throughput no no
DPYL3_HUMAN [view entry] [view interactions] High throughput yes yes
DPP6_HUMAN [view entry] [view interactions] High throughput yes no
GABT_HUMAN [view interactions] High throughput no yes
VATC1_HUMAN [view entry] [view interactions] High throughput yes yes
CAD13_HUMAN [view entry] [view interactions] High throughput yes no
DNM1L_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2B_HUMAN [view entry] [view interactions] High throughput yes yes
DYN3_HUMAN [view entry] [view interactions] High throughput yes no
TRIM3_HUMAN [view entry] [view interactions] High throughput yes no
BIN1_HUMAN [view entry] [view interactions] High throughput yes yes
AMPH_HUMAN [view entry] [view interactions] High throughput yes yes
GNAZ_HUMAN [view entry] [view interactions] High throughput yes yes
WDR47_HUMAN [view entry] [view interactions] High throughput yes yes
CBPE_HUMAN [view interactions] High throughput no yes
STX1A_HUMAN [view entry] [view interactions] High throughput yes yes
MTAP2_HUMAN [view entry] [view interactions] High throughput yes yes
MAP1A_HUMAN [view entry] [view interactions] High throughput yes yes
SEPT5_HUMAN [view interactions] High throughput no no
OGDHL_HUMAN [view entry] [view interactions] High throughput yes yes
ELAV3_HUMAN [view interactions] High throughput no yes
SYT1_HUMAN [view entry] [view interactions] High throughput yes no
SYN2_HUMAN [view entry] [view interactions] High throughput yes no
SYPH_HUMAN [view entry] [view interactions] High throughput yes yes
HPCL4_HUMAN [view interactions] High throughput no no
GNAQ_HUMAN [view entry] [view interactions] High throughput yes yes
GNAO_HUMAN [view entry] [view interactions] High throughput yes yes
PLXA4_HUMAN [view entry] [view interactions] High throughput yes no
STX1B_HUMAN [view entry] [view interactions] High throughput yes yes
PHIPL_HUMAN [view interactions] High throughput no yes
DYN1_HUMAN [view entry] [view interactions] High throughput yes yes
PPID_HUMAN [view entry] [view interactions] High throughput yes yes
DCLK1_HUMAN [view entry] [view interactions] High throughput yes yes
CNTN1_HUMAN [view entry] [view interactions] High throughput yes yes
PCDH1_HUMAN [view entry] [view interactions] High throughput yes yes
H2B1L_HUMAN [view interactions] High throughput no yes
NR2F6_HUMAN [view interactions] High throughput no no
HMCS1_HUMAN [view interactions] High throughput no yes
KAP3_HUMAN [view entry] [view interactions] High throughput yes yes
VISL1_HUMAN [view entry] [view interactions] High throughput yes no
RAB3A_HUMAN [view entry] [view interactions] High throughput yes yes
DGUOK_HUMAN [view interactions] High throughput no yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
HPCA_HUMAN [view entry] [view interactions] High throughput yes yes
SNAB_HUMAN [view entry] [view interactions] High throughput yes yes
PLXA2_HUMAN [view entry] [view interactions] High throughput yes yes
SYN3_HUMAN [view entry] [view interactions] High throughput yes yes
MARE2_HUMAN [view entry] [view interactions] High throughput yes yes
AP3B2_HUMAN [view entry] [view interactions] High throughput yes yes
NTRI_HUMAN [view entry] [view interactions] High throughput yes yes
SYNJ1_HUMAN [view entry] [view interactions] High throughput yes yes
KIF2A_HUMAN [view entry] [view interactions] High throughput yes yes
STXB1_HUMAN [view entry] [view interactions] High throughput yes yes
NAR4_HUMAN [view interactions] High throughput no no
DCX_HUMAN [view entry] [view interactions] High throughput yes yes
DPYL1_HUMAN [view entry] [view interactions] High throughput yes yes
NCALD_HUMAN [view entry] [view interactions] High throughput yes yes
S12A5_HUMAN [view entry] [view interactions] High throughput yes yes
CYRIA_HUMAN [view interactions] High throughput no yes
RAB14_HUMAN [view entry] [view interactions] High throughput yes yes
L1CAM_HUMAN [view entry] [view interactions] High throughput yes yes
AP180_HUMAN [view entry] [view interactions] High throughput yes yes
DPYL2_HUMAN [view entry] [view interactions] High throughput yes yes
MARE3_HUMAN [view entry] [view interactions] High throughput yes yes
AT2B2_HUMAN [view entry] [view interactions] High throughput yes yes
AT2B3_HUMAN [view entry] [view interactions] High throughput yes yes
ATP4A_HUMAN [view entry] [view interactions] High throughput yes no
CAPS1_HUMAN [view entry] [view interactions] High throughput yes yes
SYN1_HUMAN [view entry] [view interactions] High throughput yes no
VP26B_HUMAN [view entry] [view interactions] High throughput yes yes
TMED7_HUMAN [view interactions] High throughput no yes
CA2D1_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
EF1A2_HUMAN [view entry] [view interactions] High throughput yes yes
NAC2_HUMAN [view entry] [view interactions] High throughput yes no
RAB6B_HUMAN [view entry] [view interactions] High throughput yes yes
SNAG_HUMAN [view entry] [view interactions] High throughput yes yes
CAMKV_HUMAN [view entry] [view interactions] High throughput yes yes
CYRIB_HUMAN [view interactions] High throughput no yes
DPYL4_HUMAN [view entry] [view interactions] High throughput yes yes
SNP25_HUMAN [view entry] [view interactions] High throughput yes yes
NDRG4_HUMAN [view interactions] High throughput no no
GRIA2_HUMAN [view entry] [view interactions] High throughput yes yes
CALB2_HUMAN [view entry] [view interactions] High throughput yes yes
COR1A_HUMAN [view entry] [view interactions] High throughput yes no
SEPT3_HUMAN [view interactions] High throughput no no
YKT6_HUMAN [view interactions] High throughput no yes
ANK2_HUMAN [view entry] [view interactions] High throughput yes yes
H2AW_HUMAN [view interactions] High throughput no yes
MSS4_HUMAN [view interactions] High throughput no yes
DERL2_HUMAN [view interactions] High throughput no yes
TR10B_HUMAN [view interactions] High throughput no no
CMTD1_HUMAN [view entry] [view interactions] High throughput yes yes
RN149_HUMAN [view interactions] High throughput no no
ODR4_HUMAN [view interactions] High throughput no yes
EAA2_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
UBP48_HUMAN [view interactions] High throughput no yes
CX6A1_HUMAN [view interactions] High throughput no yes
LANC1_HUMAN [view entry] [view interactions] High throughput yes yes
NPTN_HUMAN [view entry] [view interactions] High throughput yes yes
SYT2_HUMAN [view entry] [view interactions] High throughput yes no
DIRA2_HUMAN [view entry] [view interactions] High throughput yes no
ALDOC_HUMAN [view entry] [view interactions] High throughput yes yes
KPCA_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A1_HUMAN [view entry] [view interactions] High throughput yes no
NDUBA_HUMAN [view entry] [view interactions] High throughput yes yes
NEGR1_HUMAN [view entry] [view interactions] High throughput yes yes
MYPR_HUMAN [view entry] [view interactions] High throughput yes yes
RTN1_HUMAN [view entry] [view interactions] High throughput yes yes
QCR6L_HUMAN [view interactions] High throughput no yes
QCR6_HUMAN [view interactions] High throughput no yes
CX6B1_HUMAN [view entry] [view interactions] High throughput yes yes
FBN2_HUMAN [view interactions] High throughput no no
CNOT3_HUMAN [view interactions] High throughput no yes
DHCR7_HUMAN [view interactions] High throughput no yes
KAP1_HUMAN [view entry] [view interactions] High throughput yes yes