GPM6A_HUMAN
Evidence for PS localization
Functions
Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GPM6A_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 26.2136 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 26.2136 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.2427 | 4 | no |
| GO:0046872 | metal ion binding | 25.2427 | 4 | no |
| GO:0019900 | kinase binding | 20.3883 | 4 | no |
| GO:0008324 | cation transmembrane transporter activity | 13.5922 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 13.5922 | 4 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 9.7087 | 5 | yes |
| GO:0005216 | ion channel activity | 6.7961 | 4 | yes |
| GO:0005261 | cation channel activity | 6.7961 | 5 | yes |
| GO:0015267 | channel activity | 6.7961 | 4 | yes |
| GO:0015085 | calcium ion transmembrane transporter activity | 5.8252 | 6 | yes |
| GO:0005262 | calcium channel activity | 2.9126 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GPM6A_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 48.5437 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 39.8058 | 4 | yes |
| GO:0051049 | regulation of transport | 37.8641 | 4 | no |
| GO:0010646 | regulation of cell communication | 35.9223 | 4 | no |
| GO:0022607 | cellular component assembly | 31.0680 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 30.0971 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 30.0971 | 4 | no |
| GO:0006996 | organelle organization | 29.1262 | 4 | no |
| GO:0008104 | protein localization | 26.2136 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 26.2136 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 26.2136 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 25.2427 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 25.2427 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 25.2427 | 4 | no |
| GO:0051050 | positive regulation of transport | 25.2427 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 24.2718 | 4 | no |
| GO:0030030 | cell projection organization | 23.3010 | 4 | yes |
| GO:0043269 | regulation of ion transport | 22.3301 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 21.3592 | 5 | yes |
| GO:0051046 | regulation of secretion | 21.3592 | 5 | no |
| GO:0009966 | regulation of signal transduction | 21.3592 | 4 | no |
| GO:0071702 | organic substance transport | 20.3883 | 4 | no |
| GO:0071705 | nitrogen compound transport | 20.3883 | 4 | no |
| GO:1903530 | regulation of secretion by cell | 20.3883 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 20.3883 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 19.4175 | 5 | yes |
| GO:0051130 | positive regulation of cellular component organization | 18.4466 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 18.4466 | 6 | yes |
| GO:0031175 | neuron projection development | 17.4757 | 6 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 16.5049 | 4 | yes |
| GO:0031346 | positive regulation of cell projection organization | 12.6214 | 6 | yes |
| GO:0034330 | cell junction organization | 12.6214 | 4 | yes |
| GO:0050808 | synapse organization | 10.6796 | 5 | yes |
| GO:0032990 | cell part morphogenesis | 7.7670 | 4 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 7.7670 | 5 | yes |
| GO:0050807 | regulation of synapse organization | 7.7670 | 5 | yes |
| GO:0048812 | neuron projection morphogenesis | 6.7961 | 7 | yes |
| GO:0048858 | cell projection morphogenesis | 6.7961 | 5 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 6.7961 | 6 | yes |
| GO:0034329 | cell junction assembly | 5.8252 | 5 | yes |
| GO:0007416 | synapse assembly | 3.8835 | 6 | yes |
| GO:0060491 | regulation of cell projection assembly | 3.8835 | 5 | yes |
| GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 3.8835 | 6 | yes |
| GO:0120034 | positive regulation of plasma membrane bounded cell projection assembly | 3.8835 | 6 | yes |
| GO:0001764 | neuron migration | 2.9126 | 4 | yes |
| GO:0051489 | regulation of filopodium assembly | 2.9126 | 7 | yes |
| GO:0051491 | positive regulation of filopodium assembly | 2.9126 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in GPM6A_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 4.8544 | 3 | no |
| DOID:936 | brain disease | 4.8544 | 4 | no |
| DOID:574 | peripheral nervous system disease | 1.9417 | 3 | no |
| DOID:870 | neuropathy | 1.9417 | 4 | no |
| DOID:1826 | epilepsy | 1.9417 | 5 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| OPRM_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ZDH17_HUMAN | [view interactions] | Low throughput | no | yes |
| WLS_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TIM16_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGRG5_HUMAN | [view interactions] | High throughput | no | no |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| P2RY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARMC1_HUMAN | [view interactions] | High throughput | no | yes |
| CC126_HUMAN | [view interactions] | High throughput | no | yes |
| ZDH18_HUMAN | [view interactions] | High throughput | no | yes |
| FKRP_HUMAN | [view interactions] | High throughput | no | yes |
| YIPF3_HUMAN | [view interactions] | High throughput | no | yes |
| FITM2_HUMAN | [view interactions] | High throughput | no | no |
| ERMP1_HUMAN | [view interactions] | High throughput | no | no |
| MGT5A_HUMAN | [view interactions] | High throughput | no | yes |
| TSN3_HUMAN | [view interactions] | High throughput | no | yes |
| VNN2_HUMAN | [view interactions] | High throughput | no | no |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APBB1_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAMP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGFR2_HUMAN | [view interactions] | High throughput | no | no |
| ICAM5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLF11_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RMD3_HUMAN | [view interactions] | High throughput | no | yes |
| S35B2_HUMAN | [view interactions] | High throughput | no | no |
| PLCC_HUMAN | [view interactions] | High throughput | no | no |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| IKIP_HUMAN | [view interactions] | High throughput | no | no |
| RFT1_HUMAN | [view interactions] | High throughput | no | yes |
| QCR9_HUMAN | [view interactions] | High throughput | no | no |
| F189B_HUMAN | [view interactions] | High throughput | no | no |
| SCAM2_HUMAN | [view interactions] | High throughput | no | no |
| PXMP2_HUMAN | [view interactions] | High throughput | no | no |
| GP1BB_HUMAN | [view interactions] | High throughput | no | no |
| VKORL_HUMAN | [view interactions] | High throughput | no | yes |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| TSN17_HUMAN | [view interactions] | High throughput | no | yes |
| EDA_HUMAN | [view interactions] | High throughput | no | no |
| 5HT3A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| TADBP_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2AY_HUMAN | [view interactions] | High throughput | no | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EDIL3_HUMAN | [view interactions] | High throughput | no | yes |
| HPCL1_HUMAN | [view interactions] | High throughput | no | yes |
| DPYL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB3C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| E41L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CANB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DOXA2_HUMAN | [view interactions] | High throughput | no | no |
| DPYL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPP6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GABT_HUMAN | [view interactions] | High throughput | no | yes |
| VATC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAD13_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DNM1L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRIM3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AMPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR47_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBPE_HUMAN | [view interactions] | High throughput | no | yes |
| STX1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEPT5_HUMAN | [view interactions] | High throughput | no | no |
| OGDHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELAV3_HUMAN | [view interactions] | High throughput | no | yes |
| SYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HPCL4_HUMAN | [view interactions] | High throughput | no | no |
| GNAQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLXA4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHIPL_HUMAN | [view interactions] | High throughput | no | yes |
| DYN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPID_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCLK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCDH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2B1L_HUMAN | [view interactions] | High throughput | no | yes |
| NR2F6_HUMAN | [view interactions] | High throughput | no | no |
| HMCS1_HUMAN | [view interactions] | High throughput | no | yes |
| KAP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VISL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNAB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLXA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARE2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP3B2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRI_HUMAN | [view interactions] | High throughput | no | yes |
| SYNJ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAR4_HUMAN | [view interactions] | High throughput | no | no |
| DCX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCALD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S12A5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYRIA_HUMAN | [view interactions] | High throughput | no | yes |
| RAB14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| L1CAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP180_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT2B2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT2B3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATP4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VP26B_HUMAN | [view interactions] | High throughput | no | yes |
| TMED7_HUMAN | [view interactions] | High throughput | no | yes |
| CA2D1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EF1A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB6B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNAG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAMKV_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYRIB_HUMAN | [view interactions] | High throughput | no | yes |
| DPYL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNP25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDRG4_HUMAN | [view interactions] | High throughput | no | no |
| GRIA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COR1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SEPT3_HUMAN | [view interactions] | High throughput | no | no |
| YKT6_HUMAN | [view interactions] | High throughput | no | yes |
| ANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2AW_HUMAN | [view interactions] | High throughput | no | yes |
| MSS4_HUMAN | [view interactions] | High throughput | no | yes |
| DERL2_HUMAN | [view interactions] | High throughput | no | yes |
| TR10B_HUMAN | [view interactions] | High throughput | no | no |
| CMTD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN149_HUMAN | [view interactions] | High throughput | no | no |
| ODR4_HUMAN | [view interactions] | High throughput | no | yes |
| CX6A1_HUMAN | [view interactions] | High throughput | no | yes |
| LANC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DIRA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ALDOC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDUBA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEGR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR6L_HUMAN | [view interactions] | High throughput | no | yes |
| QCR6_HUMAN | [view interactions] | High throughput | no | yes |
| CX6B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBN2_HUMAN | [view interactions] | High throughput | no | no |