Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

OGDHL_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

2-oxoglutarate dehydrogenase (E1-like) component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDHC) which mediates the decarboxylation of alpha-ketoglutarate in the tricarboxylic acid cycle. The OGDHC complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) while reducing NAD(+) to NADH . The OGDHC complex is mainly active in the mitochondrion . Involved in the inhibition of cell proliferation and in apoptosis (PubMed, PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in OGDHL_HUMAN
GO:0043168 anion binding 46.1538 4 yes
GO:0003723 RNA binding 38.4615 4 no
GO:0043169 cation binding 30.7692 4 yes
GO:0046872 metal ion binding 30.7692 5 yes
GO:0000166 nucleotide binding 30.7692 4 no
GO:0017076 purine nucleotide binding 23.0769 5 no
GO:0032555 purine ribonucleotide binding 23.0769 4 no
GO:0035639 purine ribonucleoside triphosphate binding 23.0769 4 no
GO:0003677 DNA binding 23.0769 4 no
GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity 15.3846 5 yes
GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor 15.3846 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in OGDHL_HUMAN
GO:0048522 positive regulation of cellular process 53.8462 4 no
GO:0006796 phosphate-containing compound metabolic process 53.8462 4 yes
GO:0022607 cellular component assembly 46.1538 4 no
GO:1901565 organonitrogen compound catabolic process 38.4615 4 yes
GO:0009893 positive regulation of metabolic process 38.4615 4 no
GO:0010604 positive regulation of macromolecule metabolic process 38.4615 5 no
GO:0051128 regulation of cellular component organization 38.4615 4 no
GO:0060255 regulation of macromolecule metabolic process 38.4615 4 no
GO:0080090 regulation of primary metabolic process 38.4615 4 no
GO:0006163 purine nucleotide metabolic process 38.4615 5 yes
GO:0006753 nucleoside phosphate metabolic process 38.4615 4 yes
GO:0009117 nucleotide metabolic process 38.4615 5 yes
GO:0019752 carboxylic acid metabolic process 38.4615 5 yes
GO:0043436 oxoacid metabolic process 38.4615 4 yes
GO:0072521 purine-containing compound metabolic process 38.4615 4 yes
GO:0009889 regulation of biosynthetic process 30.7692 4 no
GO:0010468 regulation of gene expression 30.7692 6 no
GO:0010556 regulation of macromolecule biosynthetic process 30.7692 5 no
GO:0030162 regulation of proteolysis 30.7692 6 no
GO:0031323 regulation of cellular metabolic process 30.7692 4 no
GO:0031326 regulation of cellular biosynthetic process 30.7692 5 no
GO:0048523 negative regulation of cellular process 30.7692 4 no
GO:0051246 regulation of protein metabolic process 30.7692 5 no
GO:0051247 positive regulation of protein metabolic process 30.7692 6 no
GO:0090304 nucleic acid metabolic process 30.7692 4 no
GO:0008104 protein localization 30.7692 4 no
GO:0006996 organelle organization 30.7692 4 no
GO:0009150 purine ribonucleotide metabolic process 30.7692 6 yes
GO:0009259 ribonucleotide metabolic process 30.7692 5 yes
GO:0019693 ribose phosphate metabolic process 30.7692 4 yes
GO:0043648 dicarboxylic acid metabolic process 30.7692 6 yes
GO:0033865 nucleoside bisphosphate metabolic process 23.0769 5 no
GO:0033875 ribonucleoside bisphosphate metabolic process 23.0769 6 no
GO:0034032 purine nucleoside bisphosphate metabolic process 23.0769 5 no
GO:0006259 DNA metabolic process 23.0769 5 no
GO:0008284 positive regulation of cell population proliferation 23.0769 5 no
GO:0009890 negative regulation of biosynthetic process 23.0769 5 no
GO:0009892 negative regulation of metabolic process 23.0769 4 no
GO:0009894 regulation of catabolic process 23.0769 4 no
GO:0009966 regulation of signal transduction 23.0769 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 23.0769 6 no
GO:0010605 negative regulation of macromolecule metabolic process 23.0769 5 no
GO:0010629 negative regulation of gene expression 23.0769 7 no
GO:0010646 regulation of cell communication 23.0769 4 no
GO:0031324 negative regulation of cellular metabolic process 23.0769 5 no
GO:0031327 negative regulation of cellular biosynthetic process 23.0769 6 no
GO:0042127 regulation of cell population proliferation 23.0769 4 no
GO:0042981 regulation of apoptotic process 23.0769 5 no
GO:0043066 negative regulation of apoptotic process 23.0769 6 no
GO:0043067 regulation of programmed cell death 23.0769 4 no
GO:0043069 negative regulation of programmed cell death 23.0769 5 no
GO:0048584 positive regulation of response to stimulus 23.0769 4 no
GO:0048585 negative regulation of response to stimulus 23.0769 4 no
GO:0051336 regulation of hydrolase activity 23.0769 4 no
GO:0051726 regulation of cell cycle 23.0769 4 no
GO:0052547 regulation of peptidase activity 23.0769 5 no
GO:0052548 regulation of endopeptidase activity 23.0769 6 no
GO:0009891 positive regulation of biosynthetic process 23.0769 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 23.0769 6 no
GO:0010628 positive regulation of gene expression 23.0769 7 no
GO:0015031 protein transport 23.0769 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 23.0769 5 no
GO:0031325 positive regulation of cellular metabolic process 23.0769 5 no
GO:0031328 positive regulation of cellular biosynthetic process 23.0769 6 no
GO:0033365 protein localization to organelle 23.0769 5 no
GO:0043085 positive regulation of catalytic activity 23.0769 4 no
GO:0045862 positive regulation of proteolysis 23.0769 7 no
GO:0071310 cellular response to organic substance 23.0769 4 no
GO:0071702 organic substance transport 23.0769 4 no
GO:0071705 nitrogen compound transport 23.0769 4 no
GO:0080134 regulation of response to stress 23.0769 4 no
GO:0043933 protein-containing complex organization 23.0769 4 no
GO:0051130 positive regulation of cellular component organization 23.0769 5 no
GO:0065003 protein-containing complex assembly 23.0769 5 no
GO:0006090 pyruvate metabolic process 23.0769 7 yes
GO:0006103 2-oxoglutarate metabolic process 23.0769 7 yes
GO:0019362 pyridine nucleotide metabolic process 23.0769 5 yes
GO:0032787 monocarboxylic acid metabolic process 23.0769 6 yes
GO:0046496 nicotinamide nucleotide metabolic process 23.0769 6 yes
GO:0072524 pyridine-containing compound metabolic process 23.0769 4 yes
GO:1901361 organic cyclic compound catabolic process 15.3846 4 yes
GO:0006096 glycolytic process 15.3846 4 yes
GO:0006195 purine nucleotide catabolic process 15.3846 6 yes
GO:0009132 nucleoside diphosphate metabolic process 15.3846 5 yes
GO:0009134 nucleoside diphosphate catabolic process 15.3846 6 yes
GO:0009135 purine nucleoside diphosphate metabolic process 15.3846 6 yes
GO:0009137 purine nucleoside diphosphate catabolic process 15.3846 7 yes
GO:0009141 nucleoside triphosphate metabolic process 15.3846 5 yes
GO:0009144 purine nucleoside triphosphate metabolic process 15.3846 6 yes
GO:0009154 purine ribonucleotide catabolic process 15.3846 6 yes
GO:0009166 nucleotide catabolic process 15.3846 6 yes
GO:0009179 purine ribonucleoside diphosphate metabolic process 15.3846 7 yes
GO:0009181 purine ribonucleoside diphosphate catabolic process 15.3846 8 yes
GO:0009185 ribonucleoside diphosphate metabolic process 15.3846 6 yes
GO:0009191 ribonucleoside diphosphate catabolic process 15.3846 7 yes
GO:0009199 ribonucleoside triphosphate metabolic process 15.3846 6 yes
GO:0009205 purine ribonucleoside triphosphate metabolic process 15.3846 7 yes
GO:0009261 ribonucleotide catabolic process 15.3846 5 yes
GO:0016052 carbohydrate catabolic process 15.3846 4 yes
GO:0019364 pyridine nucleotide catabolic process 15.3846 6 yes
GO:0034655 nucleobase-containing compound catabolic process 15.3846 4 yes
GO:0046031 ADP metabolic process 15.3846 7 yes
GO:0046032 ADP catabolic process 15.3846 7 yes
GO:0046034 ATP metabolic process 15.3846 7 yes
GO:0046434 organophosphate catabolic process 15.3846 4 yes
GO:0072523 purine-containing compound catabolic process 15.3846 5 yes
GO:0072526 pyridine-containing compound catabolic process 15.3846 5 yes
GO:1901136 carbohydrate derivative catabolic process 15.3846 4 yes
GO:1901292 nucleoside phosphate catabolic process 15.3846 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CSK21_HUMAN [view entry] [view interactions] Low throughput yes yes
STAT3_HUMAN [view entry] [view interactions] High throughput yes yes
SMYD1_HUMAN [view interactions] High throughput no no
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
IKBA_HUMAN [view interactions] High throughput no yes
ACBD7_HUMAN [view interactions] High throughput no no
SIAH2_HUMAN [view interactions] High throughput no no
HSC20_HUMAN [view interactions] High throughput no yes
KCNQ1_HUMAN [view interactions] High throughput no yes
KCNH2_HUMAN [view interactions] High throughput no no
CAV3_HUMAN [view interactions] High throughput no no
CP135_HUMAN [view interactions] High throughput no no
CDK4_HUMAN [view interactions] High throughput no no
MDM2_HUMAN [view entry] [view interactions] High throughput yes yes
CXB1_HUMAN [view interactions] High throughput no yes
CTSRE_HUMAN [view interactions] High throughput no no
MGME1_HUMAN [view interactions] High throughput no yes
TAD2A_HUMAN [view interactions] High throughput no no
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
PREP_HUMAN [view interactions] High throughput no yes
DNLI3_HUMAN [view interactions] High throughput no yes
KMT5B_HUMAN [view interactions] High throughput no no
ZN718_HUMAN [view interactions] High throughput no no
TCAIM_HUMAN [view interactions] High throughput no no
NDUF7_HUMAN [view interactions] High throughput no yes
CH60_HUMAN [view entry] [view interactions] High throughput yes yes
ARMS2_HUMAN [view interactions] High throughput no no
KGD4_HUMAN [view interactions] High throughput no yes
ODO1_HUMAN [view entry] [view interactions] High throughput yes yes
DNAI3_HUMAN [view interactions] High throughput no yes
EMC1_HUMAN [view interactions] High throughput no yes
SIAH1_HUMAN [view interactions] High throughput no yes
CPNE8_HUMAN [view interactions] High throughput no yes
XRP2_HUMAN [view entry] [view interactions] High throughput yes no
ODO2_HUMAN [view entry] [view interactions] High throughput yes yes
SYYM_HUMAN [view interactions] High throughput no no
RT24_HUMAN [view interactions] High throughput no yes
EP300_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
TOP3B_HUMAN [view interactions] High throughput no no
S13A1_HUMAN [view interactions] High throughput no no
ACAD9_HUMAN [view interactions] High throughput no yes
MDHM_HUMAN [view entry] [view interactions] High throughput yes yes
MPPB_HUMAN [view interactions] High throughput no yes
SSBP_HUMAN [view entry] [view interactions] High throughput yes yes
EFTS_HUMAN [view interactions] High throughput no no
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no