OGDHL_HUMAN
Evidence for PS localization
Functions
2-oxoglutarate dehydrogenase (E1-like) component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDHC) which mediates the decarboxylation of alpha-ketoglutarate in the tricarboxylic acid cycle. The OGDHC complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) while reducing NAD(+) to NADH . The OGDHC complex is mainly active in the mitochondrion . Involved in the inhibition of cell proliferation and in apoptosis (PubMed, PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in OGDHL_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 29.6296 | 4 | yes |
| GO:0003723 | RNA binding | 25.9259 | 4 | no |
| GO:0004591 | oxoglutarate dehydrogenase (succinyl-transferring) activity | 7.4074 | 5 | yes |
| GO:0016624 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor | 7.4074 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in OGDHL_HUMAN |
|---|---|---|---|---|
| GO:0019752 | carboxylic acid metabolic process | 66.6667 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 66.6667 | 4 | yes |
| GO:0043648 | dicarboxylic acid metabolic process | 44.4444 | 6 | yes |
| GO:0048522 | positive regulation of cellular process | 33.3333 | 4 | no |
| GO:0006103 | 2-oxoglutarate metabolic process | 29.6296 | 7 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 29.6296 | 4 | yes |
| GO:0072350 | tricarboxylic acid metabolic process | 25.9259 | 6 | no |
| GO:0006753 | nucleoside phosphate metabolic process | 22.2222 | 4 | yes |
| GO:0009117 | nucleotide metabolic process | 22.2222 | 5 | yes |
| GO:0032787 | monocarboxylic acid metabolic process | 22.2222 | 6 | yes |
| GO:0009063 | cellular amino acid catabolic process | 22.2222 | 4 | no |
| GO:0016054 | organic acid catabolic process | 22.2222 | 4 | no |
| GO:0046395 | carboxylic acid catabolic process | 22.2222 | 5 | no |
| GO:1901565 | organonitrogen compound catabolic process | 22.2222 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 22.2222 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 22.2222 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 22.2222 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 22.2222 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 22.2222 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 22.2222 | 4 | no |
| GO:1901566 | organonitrogen compound biosynthetic process | 22.2222 | 4 | no |
| GO:0006163 | purine nucleotide metabolic process | 18.5185 | 5 | yes |
| GO:0009150 | purine ribonucleotide metabolic process | 18.5185 | 6 | yes |
| GO:0009259 | ribonucleotide metabolic process | 18.5185 | 5 | yes |
| GO:0019693 | ribose phosphate metabolic process | 18.5185 | 4 | yes |
| GO:0072521 | purine-containing compound metabolic process | 18.5185 | 4 | yes |
| GO:0006090 | pyruvate metabolic process | 14.8148 | 7 | yes |
| GO:0016310 | phosphorylation | 14.8148 | 5 | yes |
| GO:0006096 | glycolytic process | 7.4074 | 5 | yes |
| GO:0006165 | nucleoside diphosphate phosphorylation | 7.4074 | 6 | yes |
| GO:0006757 | ATP generation from ADP | 7.4074 | 4 | yes |
| GO:0009132 | nucleoside diphosphate metabolic process | 7.4074 | 5 | yes |
| GO:0009135 | purine nucleoside diphosphate metabolic process | 7.4074 | 6 | yes |
| GO:0009141 | nucleoside triphosphate metabolic process | 7.4074 | 5 | yes |
| GO:0009144 | purine nucleoside triphosphate metabolic process | 7.4074 | 6 | yes |
| GO:0009179 | purine ribonucleoside diphosphate metabolic process | 7.4074 | 7 | yes |
| GO:0009185 | ribonucleoside diphosphate metabolic process | 7.4074 | 6 | yes |
| GO:0009199 | ribonucleoside triphosphate metabolic process | 7.4074 | 6 | yes |
| GO:0009205 | purine ribonucleoside triphosphate metabolic process | 7.4074 | 7 | yes |
| GO:0016052 | carbohydrate catabolic process | 7.4074 | 4 | yes |
| GO:0046031 | ADP metabolic process | 7.4074 | 7 | yes |
| GO:0046034 | ATP metabolic process | 7.4074 | 7 | yes |
| GO:0046939 | nucleotide phosphorylation | 7.4074 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in OGDHL_HUMAN |
|---|---|---|---|---|
| DOID:0050155 | sensory system disease | 7.4074 | 3 | no |
| DOID:10584 | retinitis pigmentosa | 7.4074 | 7 | no |
| DOID:5614 | eye disease | 7.4074 | 4 | no |
| DOID:8466 | retinal degeneration | 7.4074 | 6 | no |
| DOID:9799 | eye degenerative disease | 7.4074 | 5 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CSK21_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STAT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMYD1_HUMAN | [view interactions] | High throughput | no | no |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IKBA_HUMAN | [view interactions] | High throughput | no | yes |
| ACBD7_HUMAN | [view interactions] | High throughput | no | no |
| SIAH2_HUMAN | [view interactions] | High throughput | no | no |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB2_HUMAN | [view interactions] | High throughput | no | yes |
| CDK4_HUMAN | [view interactions] | High throughput | no | no |
| MDM2_HUMAN | [view interactions] | High throughput | no | yes |
| CXB1_HUMAN | [view interactions] | High throughput | no | yes |
| CTSRE_HUMAN | [view interactions] | High throughput | no | no |
| MGME1_HUMAN | [view interactions] | High throughput | no | yes |
| TAD2A_HUMAN | [view interactions] | High throughput | no | no |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PREP_HUMAN | [view interactions] | High throughput | no | yes |
| DNLI3_HUMAN | [view interactions] | High throughput | no | yes |
| KMT5B_HUMAN | [view interactions] | High throughput | no | no |
| ZN718_HUMAN | [view interactions] | High throughput | no | no |
| TCAIM_HUMAN | [view interactions] | High throughput | no | no |
| NDUF7_HUMAN | [view interactions] | High throughput | no | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARMS2_HUMAN | [view interactions] | High throughput | no | no |
| KGD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNAI3_HUMAN | [view interactions] | High throughput | no | yes |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| SIAH1_HUMAN | [view interactions] | High throughput | no | yes |
| CPNE8_HUMAN | [view interactions] | High throughput | no | yes |
| XRP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYYM_HUMAN | [view interactions] | High throughput | no | no |
| RT24_HUMAN | [view interactions] | High throughput | no | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| S13A1_HUMAN | [view interactions] | High throughput | no | no |
| ACAD9_HUMAN | [view interactions] | High throughput | no | yes |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPPB_HUMAN | [view interactions] | High throughput | no | yes |
| SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFTS_HUMAN | [view interactions] | High throughput | no | no |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SDHA_HUMAN | [view interactions] | Computational | no | yes |
| NIT2_HUMAN | [view interactions] | Computational | no | yes |
| DHE3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DHE4_HUMAN | [view interactions] | Computational | no | yes |
| PUR8_HUMAN | [view interactions] | Computational | no | yes |
| AATC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CISY_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| IDH3G_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AATM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| IDH3B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AATC2_HUMAN | [view interactions] | Computational | no | no |
| SSDH_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RIMKB_HUMAN | [view interactions] | Computational | no | no |
| IDHC_HUMAN | [view interactions] | Computational | no | no |
| ARLY_HUMAN | [view interactions] | Computational | no | no |
| ATPA_HUMAN | [view interactions] | Computational | no | yes |
| SDHB_HUMAN | [view interactions] | Computational | no | yes |
| ACON_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ALAT2_HUMAN | [view interactions] | Computational | no | yes |
| SUCA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| IDHP_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ODP2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| OXLA_HUMAN | [view interactions] | Computational | no | no |
| ALAT1_HUMAN | [view interactions] | Computational | no | no |
| IDH3A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| FUMH_HUMAN | [view entry] [view interactions] | Computational | yes | yes |