Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ODO1_HUMAN

2-oxoglutarate dehydrogenase (E1) component of the 2-oxoglutarate dehydrogenase complex (OGDHC), which mediates the decarboxylation of alpha-ketoglutarate (PubMed). The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) (PubMed). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (PubMed). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (PubMed). [View more on UniProt]

Interacting region for partners were not defined.

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in ODO1_HUMAN
GO:0046872 metal ion binding 30.1075 4 yes
GO:0003723 RNA binding 24.7312 4 no
GO:0017076 purine nucleotide binding 21.5054 4 no
GO:0032555 purine ribonucleotide binding 21.5054 4 no
GO:0035639 purine ribonucleoside triphosphate binding 20.4301 4 no
GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor 4.3011 4 yes
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 3.2258 4 yes
GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity 2.1505 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ODO1_HUMAN
GO:0048522 positive regulation of cellular process 36.5591 4 no
GO:0019752 carboxylic acid metabolic process 33.3333 5 yes
GO:0043436 oxoacid metabolic process 33.3333 4 yes
GO:0022607 cellular component assembly 32.2581 4 no
GO:0031323 regulation of cellular metabolic process 31.1828 4 no
GO:0060255 regulation of macromolecule metabolic process 31.1828 4 no
GO:0080090 regulation of primary metabolic process 30.1075 4 no
GO:0048523 negative regulation of cellular process 30.1075 4 no
GO:0006996 organelle organization 29.0323 4 no
GO:0051171 regulation of nitrogen compound metabolic process 29.0323 4 no
GO:0009893 positive regulation of metabolic process 27.9570 4 no
GO:0010468 regulation of gene expression 23.6559 5 no
GO:0031325 positive regulation of cellular metabolic process 23.6559 5 no
GO:0051128 regulation of cellular component organization 23.6559 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 23.6559 5 no
GO:0010604 positive regulation of macromolecule metabolic process 22.5806 5 no
GO:0010941 regulation of cell death 21.5054 4 no
GO:0010646 regulation of cell communication 20.4301 4 no
GO:0042981 regulation of apoptotic process 20.4301 6 no
GO:0043067 regulation of programmed cell death 20.4301 5 no
GO:0051246 regulation of protein metabolic process 20.4301 5 no
GO:0006796 phosphate-containing compound metabolic process 17.2043 4 yes
GO:0006753 nucleoside phosphate metabolic process 16.1290 4 yes
GO:0009117 nucleotide metabolic process 16.1290 5 yes
GO:0032787 monocarboxylic acid metabolic process 16.1290 6 yes
GO:0006163 purine nucleotide metabolic process 15.0538 5 yes
GO:0009150 purine ribonucleotide metabolic process 15.0538 6 yes
GO:0009259 ribonucleotide metabolic process 15.0538 5 yes
GO:0019693 ribose phosphate metabolic process 15.0538 4 yes
GO:0043648 dicarboxylic acid metabolic process 15.0538 6 yes
GO:0072521 purine-containing compound metabolic process 15.0538 4 yes
GO:0043603 cellular amide metabolic process 11.8280 4 yes
GO:0006090 pyruvate metabolic process 9.6774 7 yes
GO:0006103 2-oxoglutarate metabolic process 8.6022 7 yes
GO:0006637 acyl-CoA metabolic process 8.6022 4 yes
GO:0033865 nucleoside bisphosphate metabolic process 8.6022 5 yes
GO:0033875 ribonucleoside bisphosphate metabolic process 8.6022 6 yes
GO:0034032 purine nucleoside bisphosphate metabolic process 8.6022 5 yes
GO:0043412 macromolecule modification 8.6022 4 yes
GO:0009141 nucleoside triphosphate metabolic process 7.5269 5 yes
GO:0009144 purine nucleoside triphosphate metabolic process 7.5269 6 yes
GO:0009199 ribonucleoside triphosphate metabolic process 7.5269 6 yes
GO:0009205 purine ribonucleoside triphosphate metabolic process 7.5269 7 yes
GO:0036211 protein modification process 7.5269 4 yes
GO:0046034 ATP metabolic process 6.4516 7 yes
GO:0043543 protein acylation 5.3763 5 yes
GO:0006096 glycolytic process 3.2258 5 yes
GO:0006104 succinyl-CoA metabolic process 3.2258 5 yes
GO:0006165 nucleoside diphosphate phosphorylation 3.2258 6 yes
GO:0006757 ATP generation from ADP 3.2258 4 yes
GO:0009132 nucleoside diphosphate metabolic process 3.2258 5 yes
GO:0009135 purine nucleoside diphosphate metabolic process 3.2258 6 yes
GO:0009179 purine ribonucleoside diphosphate metabolic process 3.2258 7 yes
GO:0009185 ribonucleoside diphosphate metabolic process 3.2258 6 yes
GO:0016052 carbohydrate catabolic process 3.2258 4 yes
GO:0016310 phosphorylation 3.2258 5 yes
GO:0018335 protein succinylation 3.2258 6 yes
GO:0046031 ADP metabolic process 3.2258 7 yes
GO:0046939 nucleotide phosphorylation 3.2258 6 yes
GO:0106077 histone succinylation 3.2258 7 yes
GO:0021885 forebrain cell migration 2.1505 4 yes
GO:0022029 telencephalon cell migration 2.1505 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in ODO1_HUMAN
DOID:700 mitochondrial metabolism disease 2.1505 3 no
DOID:0050155 sensory system disease 2.1505 3 no
DOID:10584 retinitis pigmentosa 2.1505 7 no
DOID:5614 eye disease 2.1505 4 no
DOID:8466 retinal degeneration 2.1505 6 no
DOID:9799 eye degenerative disease 2.1505 5 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
UBP13_HUMAN [view interactions] Low throughput no yes
DLDH_HUMAN [view entry] [view interactions] Low throughput yes yes
ANXA2_HUMAN [view entry] [view interactions] Low throughput yes no
ODO2_HUMAN [view entry] [view interactions] Low throughput yes yes
GAL3B_HUMAN [view interactions] High throughput no yes
MRES1_HUMAN [view interactions] High throughput no yes
CH082_HUMAN [view interactions] High throughput no yes
MCUR1_HUMAN [view interactions] High throughput no no
CC90B_HUMAN [view interactions] High throughput no yes
CHCH1_HUMAN [view interactions] High throughput no yes
COX15_HUMAN [view interactions] High throughput no yes
QOR_HUMAN [view entry] [view interactions] High throughput yes yes
CISY_HUMAN [view entry] [view interactions] High throughput yes yes
DDX28_HUMAN [view interactions] High throughput no yes
DHX30_HUMAN [view entry] [view interactions] High throughput yes yes
FAKD2_HUMAN [view interactions] High throughput no no
FAKD3_HUMAN [view interactions] High throughput no yes
FAKD5_HUMAN [view interactions] High throughput no yes
EFGM_HUMAN [view interactions] High throughput no yes
RRF2M_HUMAN [view interactions] High throughput no yes
HINT2_HUMAN [view interactions] High throughput no yes
ICT1_HUMAN [view interactions] High throughput no yes
LONM_HUMAN [view entry] [view interactions] High throughput yes yes
LPPRC_HUMAN [view entry] [view interactions] High throughput yes yes
MCU_HUMAN [view interactions] High throughput no yes
MCUB_HUMAN [view interactions] High throughput no no
MDHM_HUMAN [view entry] [view interactions] High throughput yes yes
MET15_HUMAN [view interactions] High throughput no no
MET17_HUMAN [view interactions] High throughput no yes
RM11_HUMAN [view interactions] High throughput no yes
RT12_HUMAN [view interactions] High throughput no yes
RT26_HUMAN [view interactions] High throughput no yes
RRFM_HUMAN [view interactions] High throughput no yes
MTEF3_HUMAN [view interactions] High throughput no no
FMT_HUMAN [view interactions] High throughput no yes
MTG1_HUMAN [view interactions] High throughput no yes
MTG2_HUMAN [view interactions] High throughput no yes
IF2M_HUMAN [view interactions] High throughput no yes
IF3M_HUMAN [view interactions] High throughput no yes
RF1M_HUMAN [view interactions] High throughput no yes
RF1ML_HUMAN [view interactions] High throughput no yes
NGRN_HUMAN [view interactions] High throughput no yes
OTC_HUMAN [view interactions] High throughput no no
MPPA_HUMAN [view interactions] High throughput no yes
MPPB_HUMAN [view interactions] High throughput no yes
RMND1_HUMAN [view interactions] High throughput no yes
RUSD3_HUMAN [view interactions] High throughput no yes
RUSD4_HUMAN [view interactions] High throughput no yes
CMC1_HUMAN [view entry] [view interactions] High throughput yes yes
S2551_HUMAN [view interactions] High throughput no no
SLIRP_HUMAN [view interactions] High throughput no yes
SURF1_HUMAN [view interactions] High throughput no yes
TACO1_HUMAN [view interactions] High throughput no yes
FAKD4_HUMAN [view interactions] High throughput no yes
TEFM_HUMAN [view interactions] High throughput no no
TFAM_HUMAN [view entry] [view interactions] High throughput yes yes
TIM29_HUMAN [view interactions] High throughput no no
TMM70_HUMAN [view interactions] High throughput no yes
TRUB2_HUMAN [view interactions] High throughput no yes
EFTS_HUMAN [view interactions] High throughput no no
EFTU_HUMAN [view entry] [view interactions] High throughput yes yes
VWA8_HUMAN [view interactions] High throughput no yes
EXD2_HUMAN [view interactions] High throughput no yes
CLPP_HUMAN [view interactions] High throughput no yes
DJC15_HUMAN [view interactions] High throughput no no
TIM14_HUMAN [view entry] [view interactions] High throughput yes yes
GRP75_HUMAN [view entry] [view interactions] High throughput yes yes
TRAP1_HUMAN [view entry] [view interactions] High throughput yes yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
SIR4_HUMAN [view interactions] High throughput no yes
HDAC6_HUMAN [view interactions] High throughput no yes
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
SIAH2_HUMAN [view interactions] High throughput no no
ABHDB_HUMAN [view interactions] High throughput no yes
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
ESR1_HUMAN [view interactions] High throughput no no
TTC37_HUMAN [view entry] [view interactions] High throughput yes yes
MYLK4_HUMAN [view interactions] High throughput no no
NCF1_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
MK06_HUMAN [view interactions] High throughput no yes
SUMO3_HUMAN [view interactions] High throughput no yes
HSC20_HUMAN [view interactions] High throughput no yes
HSPB2_HUMAN [view interactions] High throughput no yes
KCNH2_HUMAN [view interactions] High throughput no no
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
CAV3_HUMAN [view interactions] High throughput no no
AT1B1_HUMAN [view entry] [view interactions] High throughput yes no
CNDD3_HUMAN [view interactions] High throughput no no
ACPM_HUMAN [view interactions] High throughput no yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
ATX1_HUMAN [view interactions] High throughput no yes
PLS1_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
AKIP_HUMAN [view interactions] High throughput no yes
CH60_HUMAN [view entry] [view interactions] High throughput yes yes
COX14_HUMAN [view interactions] High throughput no yes
MGST3_HUMAN [view entry] [view interactions] High throughput yes yes
PDK1_HUMAN [view interactions] High throughput no yes
TR61B_HUMAN [view interactions] High throughput no yes
IMP2L_HUMAN [view interactions] High throughput no yes
FGFR3_HUMAN [view interactions] High throughput no yes
FHI2B_HUMAN [view interactions] High throughput no yes
HCD2_HUMAN [view entry] [view interactions] High throughput yes yes
ISG15_HUMAN [view interactions] High throughput no no
MDM2_HUMAN [view interactions] High throughput no yes
ENOA_HUMAN [view entry] [view interactions] High throughput yes yes
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
UNK_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
EXOS5_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
LARP7_HUMAN [view interactions] High throughput no yes
CACO2_HUMAN [view interactions] High throughput no yes
PPT1_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
TISD_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
TRPV1_HUMAN [view entry] [view interactions] High throughput yes no
ATX3_HUMAN [view interactions] High throughput no yes
CXB1_HUMAN [view interactions] High throughput no yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
BIRC3_HUMAN [view interactions] High throughput no no
EMC1_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
AURKB_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
NUPR1_HUMAN [view interactions] High throughput no no
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
WDR76_HUMAN [view interactions] High throughput no no
P53_HUMAN [view interactions] High throughput no no
CERS2_HUMAN [view interactions] High throughput no no
OGDHL_HUMAN [view entry] [view interactions] High throughput yes yes
TCAIM_HUMAN [view interactions] High throughput no no
KGD4_HUMAN [view entry] [view interactions] High throughput yes yes
NRP1_HUMAN [view entry] [view interactions] High throughput yes yes
BASI_HUMAN [view entry] [view interactions] High throughput yes no
CLU_HUMAN [view interactions] High throughput no yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
ATG10_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
ITB1_HUMAN [view entry] [view interactions] High throughput yes no
TSR1_HUMAN [view interactions] High throughput no no
ODPA_HUMAN [view entry] [view interactions] High throughput yes yes
ODPX_HUMAN [view entry] [view interactions] High throughput yes yes
ODP2_HUMAN [view entry] [view interactions] High throughput yes yes
ODPB_HUMAN [view entry] [view interactions] High throughput yes yes
SSBP_HUMAN [view entry] [view interactions] High throughput yes yes
RM13_HUMAN [view interactions] High throughput no yes
RM15_HUMAN [view interactions] High throughput no yes
PYRD_HUMAN [view interactions] High throughput no yes
RT02_HUMAN [view interactions] High throughput no no
RM41_HUMAN [view interactions] High throughput no yes
SCFD1_HUMAN [view entry] [view interactions] High throughput yes yes
CPSF7_HUMAN [view interactions] High throughput no yes
RM38_HUMAN [view interactions] High throughput no yes
ATP5H_HUMAN [view interactions] High throughput no yes
COX5A_HUMAN [view entry] [view interactions] High throughput yes yes
CY1_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS4_HUMAN [view interactions] High throughput no yes
AT1B3_HUMAN [view interactions] High throughput no yes
NDUS2_HUMAN [view entry] [view interactions] High throughput yes yes
SUCA_HUMAN [view entry] [view interactions] High throughput yes yes
SUCB2_HUMAN [view interactions] High throughput no no
NB5R3_HUMAN [view interactions] High throughput no yes
SCPDL_HUMAN [view entry] [view interactions] High throughput yes yes
ADAS_HUMAN [view interactions] High throughput no yes
ECHA_HUMAN [view entry] [view interactions] High throughput yes yes
ATPB_HUMAN [view interactions] High throughput no yes
QCR2_HUMAN [view entry] [view interactions] High throughput yes yes
PHB2_HUMAN [view entry] [view interactions] High throughput yes yes
NB5R1_HUMAN [view entry] [view interactions] High throughput yes yes
ECHB_HUMAN [view entry] [view interactions] High throughput yes yes
GBG5_HUMAN [view interactions] High throughput no no
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
MGST1_HUMAN [view interactions] High throughput no no
ATPA_HUMAN [view interactions] High throughput no yes
APOE_HUMAN [view entry] [view interactions] High throughput yes yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
SFXN1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB1A_HUMAN [view entry] [view interactions] High throughput yes yes
ATPG_HUMAN [view interactions] High throughput no yes
FKBP9_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
PREB_HUMAN [view interactions] High throughput no yes
STML2_HUMAN [view entry] [view interactions] High throughput yes yes
NDUC2_HUMAN [view interactions] High throughput no yes
ATPO_HUMAN [view interactions] High throughput no yes
TOM22_HUMAN [view interactions] High throughput no yes
LETM1_HUMAN [view entry] [view interactions] High throughput yes yes
NIPS1_HUMAN [view entry] [view interactions] High throughput yes yes
QCR1_HUMAN [view entry] [view interactions] High throughput yes yes
COX2_HUMAN [view entry] [view interactions] High throughput yes yes
MCAT_HUMAN [view interactions] High throughput no yes
PRDX3_HUMAN [view interactions] High throughput no yes
MTCH2_HUMAN [view entry] [view interactions] High throughput yes yes
EF2_HUMAN [view entry] [view interactions] High throughput yes yes
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
CX7A2_HUMAN [view interactions] High throughput no no
NDUA6_HUMAN [view interactions] High throughput no no
NDUA8_HUMAN [view entry] [view interactions] High throughput yes yes
NDUB4_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS1_HUMAN [view entry] [view interactions] High throughput yes no
NDUS3_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS5_HUMAN [view interactions] High throughput no yes
NDUS8_HUMAN [view interactions] High throughput no yes
NDUV1_HUMAN [view entry] [view interactions] High throughput yes yes
RCAF1_HUMAN [view interactions] High throughput no yes
COA3_HUMAN [view interactions] High throughput no yes
EMC2_HUMAN [view interactions] High throughput no yes
MIC10_HUMAN [view interactions] High throughput no yes
TOM5_HUMAN [view interactions] High throughput no yes
ZN782_HUMAN [view interactions] High throughput no yes
PCCB_HUMAN [view interactions] High throughput no yes
QCR8_HUMAN [view interactions] High throughput no yes
VDAC1_HUMAN [view entry] [view interactions] High throughput yes yes
VDAC2_HUMAN [view entry] [view interactions] High throughput yes yes
DHX9_HUMAN [view interactions] High throughput no yes
RL30_HUMAN [view entry] [view interactions] High throughput yes yes
RS18_HUMAN [view entry] [view interactions] High throughput yes yes
MIRO1_HUMAN [view entry] [view interactions] High throughput yes yes
SUCB1_HUMAN [view entry] [view interactions] High throughput yes yes
ACON_HUMAN [view entry] [view interactions] High throughput yes yes
SDHA_HUMAN [view interactions] High throughput no yes
SDHB_HUMAN [view interactions] High throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
MRM1_HUMAN [view interactions] High throughput no no
GRSF1_HUMAN [view interactions] High throughput no yes
ACAD9_HUMAN [view interactions] High throughput no yes
AUHM_HUMAN [view entry] [view interactions] High throughput yes yes
MTRFR_HUMAN [view interactions] High throughput no yes
CQ080_HUMAN [view interactions] High throughput no yes
C1QBP_HUMAN [view entry] [view interactions] High throughput yes yes
GAL3A_HUMAN [view interactions] High throughput no yes
DHE3_HUMAN [view entry] [view interactions] Computational yes yes
DHE4_HUMAN [view interactions] Computational no yes
ODB2_HUMAN [view entry] [view interactions] Computational yes yes
IDHC_HUMAN [view interactions] Computational no no
ARLY_HUMAN [view interactions] Computational no no
NIT2_HUMAN [view interactions] Computational no yes
PUR8_HUMAN [view interactions] Computational no yes
AATC_HUMAN [view entry] [view interactions] Computational yes yes
GCSH_HUMAN [view interactions] Computational no yes
ODBA_HUMAN [view interactions] Computational no yes
C560_HUMAN [view interactions] Computational no no
IDH3G_HUMAN [view entry] [view interactions] Computational yes yes
ALAT2_HUMAN [view interactions] Computational no yes
LIPT_HUMAN [view interactions] Computational no no
IDHP_HUMAN [view entry] [view interactions] Computational yes yes
AATM_HUMAN [view entry] [view interactions] Computational yes yes
ALAT1_HUMAN [view interactions] Computational no no
OXLA_HUMAN [view interactions] Computational no no
FUMH_HUMAN [view entry] [view interactions] Computational yes yes
SSDH_HUMAN [view entry] [view interactions] Computational yes yes
RIMKB_HUMAN [view interactions] Computational no no
IDH3B_HUMAN [view entry] [view interactions] Computational yes yes
IDH3A_HUMAN [view entry] [view interactions] Computational yes yes
AATC2_HUMAN [view interactions] Computational no no