SUCB1_HUMAN
Evidence for PS localization
Functions
ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA (PubMed). The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SUCB1_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 32.3944 | 4 | yes |
| GO:0015399 | primary active transmembrane transporter activity | 22.5352 | 4 | no |
| GO:0003723 | RNA binding | 22.5352 | 4 | no |
| GO:0015453 | oxidoreduction-driven active transmembrane transporter activity | 21.1268 | 5 | no |
| GO:0017076 | purine nucleotide binding | 18.3099 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 18.3099 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 18.3099 | 4 | yes |
| GO:0005524 | ATP binding | 12.6761 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 12.6761 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 12.6761 | 5 | yes |
| GO:0000287 | magnesium ion binding | 4.2254 | 5 | yes |
| GO:0004774 | succinate-CoA ligase activity | 2.8169 | 5 | yes |
| GO:0004775 | succinate-CoA ligase (ADP-forming) activity | 2.8169 | 6 | yes |
| GO:0004776 | succinate-CoA ligase (GDP-forming) activity | 2.8169 | 6 | yes |
| GO:0016878 | acid-thiol ligase activity | 2.8169 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SUCB1_HUMAN |
|---|---|---|---|---|
| GO:0043933 | protein-containing complex organization | 30.9859 | 4 | no |
| GO:0022607 | cellular component assembly | 30.9859 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 29.5775 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 29.5775 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 26.7606 | 4 | no |
| GO:0015980 | energy derivation by oxidation of organic compounds | 26.7606 | 4 | no |
| GO:0022900 | electron transport chain | 26.7606 | 4 | no |
| GO:0022904 | respiratory electron transport chain | 26.7606 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 26.7606 | 5 | no |
| GO:0009060 | aerobic respiration | 25.3521 | 6 | no |
| GO:0045333 | cellular respiration | 25.3521 | 5 | no |
| GO:0019646 | aerobic electron transport chain | 22.5352 | 6 | no |
| GO:0031323 | regulation of cellular metabolic process | 22.5352 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 22.5352 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 22.5352 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 22.5352 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 21.1268 | 4 | no |
| GO:0043603 | cellular amide metabolic process | 16.9014 | 4 | yes |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 16.9014 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 15.4930 | 4 | yes |
| GO:0006753 | nucleoside phosphate metabolic process | 14.0845 | 4 | yes |
| GO:0009117 | nucleotide metabolic process | 14.0845 | 5 | yes |
| GO:0018130 | heterocycle biosynthetic process | 14.0845 | 4 | yes |
| GO:0019438 | aromatic compound biosynthetic process | 14.0845 | 4 | yes |
| GO:1901362 | organic cyclic compound biosynthetic process | 14.0845 | 4 | yes |
| GO:0006163 | purine nucleotide metabolic process | 12.6761 | 5 | yes |
| GO:0009150 | purine ribonucleotide metabolic process | 12.6761 | 6 | yes |
| GO:0009259 | ribonucleotide metabolic process | 12.6761 | 5 | yes |
| GO:0019693 | ribose phosphate metabolic process | 12.6761 | 4 | yes |
| GO:0072521 | purine-containing compound metabolic process | 12.6761 | 4 | yes |
| GO:1901566 | organonitrogen compound biosynthetic process | 12.6761 | 4 | yes |
| GO:0006637 | acyl-CoA metabolic process | 11.2676 | 4 | yes |
| GO:0033865 | nucleoside bisphosphate metabolic process | 11.2676 | 5 | yes |
| GO:0033875 | ribonucleoside bisphosphate metabolic process | 11.2676 | 6 | yes |
| GO:0034032 | purine nucleoside bisphosphate metabolic process | 11.2676 | 5 | yes |
| GO:0043648 | dicarboxylic acid metabolic process | 9.8592 | 6 | yes |
| GO:0006104 | succinyl-CoA metabolic process | 4.2254 | 5 | yes |
| GO:0006778 | porphyrin-containing compound metabolic process | 2.8169 | 5 | yes |
| GO:0006779 | porphyrin-containing compound biosynthetic process | 2.8169 | 6 | yes |
| GO:0033013 | tetrapyrrole metabolic process | 2.8169 | 4 | yes |
| GO:0033014 | tetrapyrrole biosynthetic process | 2.8169 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in SUCB1_HUMAN |
|---|---|---|---|---|
| DOID:700 | mitochondrial metabolism disease | 2.8169 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| HEM0_HUMAN | [view interactions] | Low throughput | no | no |
| SUCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DPPA3_HUMAN | [view interactions] | High throughput | no | no |
| GRSF1_HUMAN | [view interactions] | High throughput | no | yes |
| ACAD9_HUMAN | [view interactions] | High throughput | no | yes |
| AUHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTRFR_HUMAN | [view interactions] | High throughput | no | yes |
| C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | yes |
| MRES1_HUMAN | [view interactions] | High throughput | no | yes |
| CC90B_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD5_HUMAN | [view interactions] | High throughput | no | yes |
| HINT2_HUMAN | [view interactions] | High throughput | no | yes |
| LONM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCU_HUMAN | [view interactions] | High throughput | no | yes |
| MCUB_HUMAN | [view interactions] | High throughput | no | no |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET15_HUMAN | [view interactions] | High throughput | no | no |
| MET17_HUMAN | [view interactions] | High throughput | no | yes |
| RM11_HUMAN | [view interactions] | High throughput | no | yes |
| RT26_HUMAN | [view interactions] | High throughput | no | yes |
| RRFM_HUMAN | [view interactions] | High throughput | no | yes |
| MTEF3_HUMAN | [view interactions] | High throughput | no | no |
| MTG2_HUMAN | [view interactions] | High throughput | no | yes |
| IF3M_HUMAN | [view interactions] | High throughput | no | yes |
| RF1M_HUMAN | [view interactions] | High throughput | no | yes |
| RF1ML_HUMAN | [view interactions] | High throughput | no | yes |
| RUSD4_HUMAN | [view interactions] | High throughput | no | yes |
| SLIRP_HUMAN | [view interactions] | High throughput | no | yes |
| SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TACO1_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| TFAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMM70_HUMAN | [view interactions] | High throughput | no | yes |
| TRUB2_HUMAN | [view interactions] | High throughput | no | yes |
| EFTS_HUMAN | [view interactions] | High throughput | no | no |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VWA8_HUMAN | [view interactions] | High throughput | no | yes |
| EXD2_HUMAN | [view interactions] | High throughput | no | yes |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| SYAM_HUMAN | [view interactions] | High throughput | no | yes |
| COX8A_HUMAN | [view interactions] | High throughput | no | yes |
| TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTR1A_HUMAN | [view interactions] | High throughput | no | no |
| AGO4_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSDE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ICT1_HUMAN | [view interactions] | High throughput | no | yes |
| SIR4_HUMAN | [view interactions] | High throughput | no | yes |
| HEM6_HUMAN | [view interactions] | High throughput | no | no |
| HEMH_HUMAN | [view interactions] | High throughput | no | yes |
| PPOX_HUMAN | [view interactions] | High throughput | no | no |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGRC2_HUMAN | [view interactions] | High throughput | no | yes |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| ATPA_HUMAN | [view interactions] | High throughput | no | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| DHRS7_HUMAN | [view interactions] | High throughput | no | yes |
| CKAP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRC36_HUMAN | [view interactions] | High throughput | no | no |
| B2L14_HUMAN | [view interactions] | High throughput | no | yes |
| IRF2_HUMAN | [view interactions] | High throughput | no | yes |
| 5NT3A_HUMAN | [view interactions] | High throughput | no | yes |
| TR10A_HUMAN | [view interactions] | High throughput | no | no |
| KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| TX101_HUMAN | [view interactions] | High throughput | no | no |
| AR6P1_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP7_HUMAN | [view interactions] | High throughput | no | yes |
| SC23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAGAB_HUMAN | [view interactions] | High throughput | no | no |
| MAL2_HUMAN | [view interactions] | High throughput | no | no |
| TR10D_HUMAN | [view interactions] | High throughput | no | no |
| OPTN_HUMAN | [view interactions] | High throughput | no | yes |
| LMBL1_HUMAN | [view interactions] | High throughput | no | no |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDK1_HUMAN | [view interactions] | High throughput | no | yes |
| TR61B_HUMAN | [view interactions] | High throughput | no | yes |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| FHI1B_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2A_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
| ATRAP_HUMAN | [view interactions] | High throughput | no | yes |
| CKLF5_HUMAN | [view interactions] | High throughput | no | yes |
| FAM9B_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| TNPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBXN8_HUMAN | [view interactions] | High throughput | no | yes |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| NFAC2_HUMAN | [view interactions] | High throughput | no | yes |
| MAP2_HUMAN | [view interactions] | High throughput | no | yes |
| RAD21_HUMAN | [view interactions] | High throughput | no | yes |
| DNLZ_HUMAN | [view interactions] | High throughput | no | no |
| IF2M_HUMAN | [view interactions] | High throughput | no | yes |
| CQ080_HUMAN | [view interactions] | High throughput | no | yes |
| ZMY19_HUMAN | [view interactions] | High throughput | no | yes |
| IQGA2_HUMAN | [view interactions] | High throughput | no | yes |
| GTPBA_HUMAN | [view interactions] | High throughput | no | yes |
| MKLN1_HUMAN | [view interactions] | High throughput | no | yes |
| SYHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OZF_HUMAN | [view interactions] | High throughput | no | yes |
| LONP2_HUMAN | [view interactions] | High throughput | no | yes |
| EFGM_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| DIRA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MAEA_HUMAN | [view interactions] | High throughput | no | yes |
| NXPH1_HUMAN | [view interactions] | High throughput | no | no |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| ZFYV1_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDHA_HUMAN | [view interactions] | High throughput | no | yes |
| GRHPR_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NIT2_HUMAN | [view interactions] | High throughput | no | yes |
| SCOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HPDL_HUMAN | [view interactions] | High throughput | no | no |
| S10AG_HUMAN | [view interactions] | High throughput | no | no |
| SC22B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAKD2_HUMAN | [view interactions] | High throughput | no | yes |
| RM12_HUMAN | [view interactions] | High throughput | no | yes |
| RBM4_HUMAN | [view interactions] | High throughput | no | yes |
| AGFG1_HUMAN | [view interactions] | High throughput | no | yes |
| IDH3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSRD_HUMAN | [view interactions] | High throughput | no | yes |
| ACADM_HUMAN | [view interactions] | High throughput | no | yes |
| ETFA_HUMAN | [view interactions] | High throughput | no | yes |
| NFS1_HUMAN | [view interactions] | High throughput | no | yes |
| PRS7_HUMAN | [view interactions] | High throughput | no | yes |
| SDHB_HUMAN | [view interactions] | High throughput | no | yes |
| SH3L3_HUMAN | [view interactions] | High throughput | no | no |
| GRPE1_HUMAN | [view interactions] | High throughput | no | yes |
| ADRO_HUMAN | [view interactions] | High throughput | no | no |
| FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UCHL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYYM_HUMAN | [view interactions] | High throughput | no | no |
| ABHDA_HUMAN | [view interactions] | High throughput | no | yes |
| PPA6_HUMAN | [view interactions] | High throughput | no | no |
| ANXA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HTRA2_HUMAN | [view interactions] | High throughput | no | yes |
| PLGT3_HUMAN | [view interactions] | High throughput | no | no |
| MDHC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NNRE_HUMAN | [view interactions] | High throughput | no | yes |
| PREP_HUMAN | [view interactions] | High throughput | no | yes |
| MPPA_HUMAN | [view interactions] | High throughput | no | yes |
| MPPB_HUMAN | [view interactions] | High throughput | no | yes |
| SODM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NFU1_HUMAN | [view interactions] | High throughput | no | yes |
| ORN_HUMAN | [view interactions] | High throughput | no | no |
| SUCB2_HUMAN | [view interactions] | High throughput | no | no |
| ETFD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUBA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS4_HUMAN | [view interactions] | High throughput | no | yes |
| ODO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR6L_HUMAN | [view interactions] | High throughput | no | yes |
| QCR6_HUMAN | [view interactions] | High throughput | no | yes |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIC26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDDC2_HUMAN | [view interactions] | High throughput | no | yes |
| IDH3G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA3_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDUS2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDUV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPG_HUMAN | [view interactions] | High throughput | no | yes |
| AT5F1_HUMAN | [view interactions] | High throughput | no | yes |
| ATP5I_HUMAN | [view interactions] | High throughput | no | yes |
| COX6C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUAC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDHF3_HUMAN | [view interactions] | High throughput | no | yes |
| MRM1_HUMAN | [view interactions] | High throughput | no | no |