Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SUCB1_HUMAN

ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA (PubMed). The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit . [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in SUCB1_HUMAN
GO:0043169 cation binding 32.9114 4 yes
GO:0046872 metal ion binding 32.9114 5 yes
GO:0000166 nucleotide binding 27.8481 4 yes
GO:0043168 anion binding 25.3165 4 yes
GO:0017076 purine nucleotide binding 24.0506 5 yes
GO:0003723 RNA binding 22.7848 4 no
GO:0008324 monoatomic cation transmembrane transporter activity 22.7848 4 no
GO:0022890 inorganic cation transmembrane transporter activity 22.7848 4 no
GO:0015078 proton transmembrane transporter activity 20.2532 5 no
GO:0015399 primary active transmembrane transporter activity 20.2532 4 no
GO:0022853 active monoatomic ion transmembrane transporter activity 20.2532 4 no
GO:0030554 adenyl nucleotide binding 18.9873 6 yes
GO:0032555 purine ribonucleotide binding 18.9873 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 18.9873 4 yes
GO:0005524 ATP binding 13.9241 5 yes
GO:0032559 adenyl ribonucleotide binding 13.9241 5 yes
GO:0000287 magnesium ion binding 3.7975 6 yes
GO:0004774 succinate-CoA ligase activity 2.5316 5 yes
GO:0004775 succinate-CoA ligase (ADP-forming) activity 2.5316 6 yes
GO:0016878 acid-thiol ligase activity 2.5316 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SUCB1_HUMAN
GO:0043933 protein-containing complex organization 34.1772 4 no
GO:0006796 phosphate-containing compound metabolic process 32.9114 4 yes
GO:0006753 nucleoside phosphate metabolic process 30.3797 4 yes
GO:0009117 nucleotide metabolic process 30.3797 5 yes
GO:0022607 cellular component assembly 30.3797 4 no
GO:0006163 purine nucleotide metabolic process 29.1139 5 yes
GO:0072521 purine-containing compound metabolic process 29.1139 4 yes
GO:0031323 regulation of cellular metabolic process 27.8481 4 no
GO:0048522 positive regulation of cellular process 27.8481 4 no
GO:0060255 regulation of macromolecule metabolic process 27.8481 4 no
GO:0065003 protein-containing complex assembly 27.8481 5 no
GO:0080090 regulation of primary metabolic process 27.8481 4 no
GO:0009150 purine ribonucleotide metabolic process 26.5823 6 yes
GO:0009259 ribonucleotide metabolic process 26.5823 5 yes
GO:0019693 ribose phosphate metabolic process 26.5823 4 yes
GO:1901362 organic cyclic compound biosynthetic process 26.5823 4 yes
GO:0019752 carboxylic acid metabolic process 25.3165 5 yes
GO:0043436 oxoacid metabolic process 25.3165 4 yes
GO:1901566 organonitrogen compound biosynthetic process 25.3165 4 yes
GO:0015980 energy derivation by oxidation of organic compounds 25.3165 4 no
GO:0022900 electron transport chain 25.3165 4 no
GO:0022904 respiratory electron transport chain 25.3165 5 no
GO:0006996 organelle organization 24.0506 4 no
GO:0048523 negative regulation of cellular process 24.0506 4 no
GO:0009060 aerobic respiration 24.0506 6 no
GO:0034654 nucleobase-containing compound biosynthetic process 24.0506 4 no
GO:0045333 cellular respiration 24.0506 5 no
GO:0051128 regulation of cellular component organization 21.5190 4 no
GO:0009165 nucleotide biosynthetic process 21.5190 6 no
GO:0019646 aerobic electron transport chain 21.5190 6 no
GO:0090407 organophosphate biosynthetic process 21.5190 4 no
GO:1901137 carbohydrate derivative biosynthetic process 21.5190 4 no
GO:1901293 nucleoside phosphate biosynthetic process 21.5190 5 no
GO:0006164 purine nucleotide biosynthetic process 20.2532 6 no
GO:0009152 purine ribonucleotide biosynthetic process 20.2532 7 no
GO:0009260 ribonucleotide biosynthetic process 20.2532 6 no
GO:0046390 ribose phosphate biosynthetic process 20.2532 5 no
GO:0072522 purine-containing compound biosynthetic process 20.2532 5 no
GO:1901565 organonitrogen compound catabolic process 17.7215 4 yes
GO:0033865 nucleoside bisphosphate metabolic process 11.3924 5 yes
GO:0033875 ribonucleoside bisphosphate metabolic process 11.3924 6 yes
GO:0034032 purine nucleoside bisphosphate metabolic process 11.3924 5 yes
GO:0043648 dicarboxylic acid metabolic process 8.8608 6 yes
GO:0006104 succinyl-CoA metabolic process 5.0633 4 yes
GO:0034655 nucleobase-containing compound catabolic process 5.0633 4 yes
GO:1901361 organic cyclic compound catabolic process 5.0633 4 yes
GO:0006195 purine nucleotide catabolic process 3.7975 6 yes
GO:0009154 purine ribonucleotide catabolic process 3.7975 6 yes
GO:0009166 nucleotide catabolic process 3.7975 6 yes
GO:0009261 ribonucleotide catabolic process 3.7975 5 yes
GO:0046434 organophosphate catabolic process 3.7975 4 yes
GO:0072523 purine-containing compound catabolic process 3.7975 5 yes
GO:1901136 carbohydrate derivative catabolic process 3.7975 4 yes
GO:1901292 nucleoside phosphate catabolic process 3.7975 5 yes
GO:0006778 porphyrin-containing compound metabolic process 2.5316 5 yes
GO:0006779 porphyrin-containing compound biosynthetic process 2.5316 6 yes
GO:0033013 tetrapyrrole metabolic process 2.5316 4 yes
GO:0033014 tetrapyrrole biosynthetic process 2.5316 5 yes
GO:0033869 nucleoside bisphosphate catabolic process 2.5316 6 yes
GO:0034031 ribonucleoside bisphosphate catabolic process 2.5316 7 yes
GO:0034034 purine nucleoside bisphosphate catabolic process 2.5316 6 yes
GO:0044273 sulfur compound catabolic process 2.5316 4 yes
GO:1901289 succinyl-CoA catabolic process 2.5316 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
HEM0_HUMAN [view interactions] Low throughput no no
SUCA_HUMAN [view entry] [view interactions] Low throughput yes yes
SODM_HUMAN [view entry] [view interactions] High throughput yes no
COF2_HUMAN [view entry] [view interactions] High throughput yes yes
NFU1_HUMAN [view interactions] High throughput no yes
ORN_HUMAN [view interactions] High throughput no no
SUCB2_HUMAN [view interactions] High throughput no no
ETFD_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA4_HUMAN [view entry] [view interactions] High throughput yes yes
NDUBA_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS4_HUMAN [view interactions] High throughput no yes
ODO1_HUMAN [view entry] [view interactions] High throughput yes yes
ODPX_HUMAN [view entry] [view interactions] High throughput yes yes
QCR6L_HUMAN [view interactions] High throughput no yes
QCR6_HUMAN [view interactions] High throughput no yes
ACON_HUMAN [view entry] [view interactions] High throughput yes yes
MIC26_HUMAN [view entry] [view interactions] High throughput yes yes
ARRB2_HUMAN [view entry] [view interactions] High throughput yes no
CISY_HUMAN [view entry] [view interactions] High throughput yes yes
CY1_HUMAN [view entry] [view interactions] High throughput yes yes
ODP2_HUMAN [view entry] [view interactions] High throughput yes yes
HDDC2_HUMAN [view interactions] High throughput no yes
IDH3G_HUMAN [view entry] [view interactions] High throughput yes yes
NDUAA_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA3_HUMAN [view interactions] High throughput no yes
NDUA8_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS1_HUMAN [view entry] [view interactions] High throughput yes no
NDUS2_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS3_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS7_HUMAN [view entry] [view interactions] High throughput yes no
NDUV2_HUMAN [view entry] [view interactions] High throughput yes yes
ODPA_HUMAN [view entry] [view interactions] High throughput yes yes
ODPB_HUMAN [view entry] [view interactions] High throughput yes yes
QCR1_HUMAN [view entry] [view interactions] High throughput yes yes
QCR2_HUMAN [view entry] [view interactions] High throughput yes yes
UCRI_HUMAN [view entry] [view interactions] High throughput yes yes
ATPG_HUMAN [view interactions] High throughput no yes
AT5F1_HUMAN [view interactions] High throughput no yes
ATP5I_HUMAN [view interactions] High throughput no yes
COX6C_HUMAN [view entry] [view interactions] High throughput yes yes
NDUAC_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA5_HUMAN [view entry] [view interactions] High throughput yes yes
NDUV1_HUMAN [view entry] [view interactions] High throughput yes yes
SDHF3_HUMAN [view interactions] High throughput no yes
ES8L2_HUMAN [view interactions] High throughput no yes
MRM1_HUMAN [view interactions] High throughput no no
DPPA3_HUMAN [view interactions] High throughput no no
GRSF1_HUMAN [view interactions] High throughput no yes
ACAD9_HUMAN [view interactions] High throughput no yes
AUHM_HUMAN [view entry] [view interactions] High throughput yes yes
MTRFR_HUMAN [view interactions] High throughput no yes
C1QBP_HUMAN [view entry] [view interactions] High throughput yes yes
GAL3A_HUMAN [view interactions] High throughput no yes
GAL3B_HUMAN [view interactions] High throughput no no
MRES1_HUMAN [view interactions] High throughput no yes
CC90B_HUMAN [view interactions] High throughput no yes
FAKD5_HUMAN [view interactions] High throughput no yes
HINT2_HUMAN [view interactions] High throughput no yes
LONM_HUMAN [view entry] [view interactions] High throughput yes yes
LPPRC_HUMAN [view entry] [view interactions] High throughput yes yes
MCU_HUMAN [view interactions] High throughput no yes
MCUB_HUMAN [view interactions] High throughput no no
MDHM_HUMAN [view entry] [view interactions] High throughput yes yes
MET15_HUMAN [view interactions] High throughput no no
MET17_HUMAN [view interactions] High throughput no yes
RM11_HUMAN [view interactions] High throughput no yes
RT26_HUMAN [view interactions] High throughput no yes
RRFM_HUMAN [view interactions] High throughput no yes
MTEF3_HUMAN [view interactions] High throughput no no
MTG2_HUMAN [view interactions] High throughput no yes
IF3M_HUMAN [view interactions] High throughput no yes
RF1M_HUMAN [view interactions] High throughput no yes
RF1ML_HUMAN [view interactions] High throughput no yes
RUSD4_HUMAN [view interactions] High throughput no yes
SLIRP_HUMAN [view interactions] High throughput no yes
SSBP_HUMAN [view entry] [view interactions] High throughput yes yes
TACO1_HUMAN [view interactions] High throughput no yes
FAKD4_HUMAN [view interactions] High throughput no yes
TFAM_HUMAN [view entry] [view interactions] High throughput yes yes
TMM70_HUMAN [view interactions] High throughput no yes
TRUB2_HUMAN [view interactions] High throughput no yes
EFTS_HUMAN [view interactions] High throughput no no
EFTU_HUMAN [view entry] [view interactions] High throughput yes yes
VWA8_HUMAN [view interactions] High throughput no yes
EXD2_HUMAN [view interactions] High throughput no yes
CLPP_HUMAN [view interactions] High throughput no yes
SYAM_HUMAN [view interactions] High throughput no yes
COX8A_HUMAN [view interactions] High throughput no yes
TRAP1_HUMAN [view entry] [view interactions] High throughput yes yes
LMNA_HUMAN [view entry] [view interactions] High throughput yes yes
CNOT3_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
MTR1A_HUMAN [view interactions] High throughput no no
AGO4_HUMAN [view interactions] High throughput no no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
PSDE_HUMAN [view entry] [view interactions] High throughput yes yes
ICT1_HUMAN [view interactions] High throughput no yes
SIR4_HUMAN [view interactions] High throughput no yes
HEM6_HUMAN [view interactions] High throughput no no
HEMH_HUMAN [view interactions] High throughput no yes
PPOX_HUMAN [view interactions] High throughput no no
PGRC1_HUMAN [view entry] [view interactions] High throughput yes yes
PGRC2_HUMAN [view interactions] High throughput no yes
COQ9_HUMAN [view interactions] High throughput no yes
ATPA_HUMAN [view interactions] High throughput no yes
PRD16_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
SIM43_HUMAN [view interactions] High throughput no no
DHRS7_HUMAN [view interactions] High throughput no yes
LRC36_HUMAN [view interactions] High throughput no no
CKAP5_HUMAN [view entry] [view interactions] High throughput yes yes
B2L14_HUMAN [view interactions] High throughput no yes
IRF2_HUMAN [view interactions] High throughput no yes
5NT3A_HUMAN [view interactions] High throughput no yes
TR10A_HUMAN [view interactions] High throughput no no
KCMA1_HUMAN [view entry] [view interactions] High throughput yes no
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
HSC20_HUMAN [view interactions] High throughput no yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
CAV3_HUMAN [view interactions] High throughput no no
TX101_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
ITM2B_HUMAN [view interactions] High throughput no yes
AR6P1_HUMAN [view interactions] High throughput no yes
FKBP7_HUMAN [view interactions] High throughput no yes
SC23A_HUMAN [view entry] [view interactions] High throughput yes yes
MAGAB_HUMAN [view interactions] High throughput no no
MAL2_HUMAN [view interactions] High throughput no no
TR10D_HUMAN [view interactions] High throughput no no
OPTN_HUMAN [view interactions] High throughput no yes
LMBL1_HUMAN [view interactions] High throughput no no
CH60_HUMAN [view entry] [view interactions] High throughput yes yes
MGST3_HUMAN [view entry] [view interactions] High throughput yes yes
PDK1_HUMAN [view interactions] High throughput no yes
TR61B_HUMAN [view interactions] High throughput no yes
IMP2L_HUMAN [view interactions] High throughput no yes
FHI1B_HUMAN [view interactions] High throughput no yes
FHI2A_HUMAN [view interactions] High throughput no yes
FHI2B_HUMAN [view interactions] High throughput no yes
ATRAP_HUMAN [view interactions] High throughput no yes
CKLF5_HUMAN [view interactions] High throughput no yes
FAM9B_HUMAN [view interactions] High throughput no no
SPAG6_HUMAN [view interactions] High throughput no no
EGFR_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
TNPO1_HUMAN [view entry] [view interactions] High throughput yes yes
UBXN8_HUMAN [view interactions] High throughput no yes
FAF2_HUMAN [view interactions] High throughput no yes
NFAC2_HUMAN [view interactions] High throughput no yes
MAP2_HUMAN [view interactions] High throughput no yes
RAD21_HUMAN [view interactions] High throughput no yes
DNLZ_HUMAN [view interactions] High throughput no no
IF2M_HUMAN [view interactions] High throughput no yes
CQ080_HUMAN [view interactions] High throughput no yes
ZMY19_HUMAN [view interactions] High throughput no yes
IQGA2_HUMAN [view interactions] High throughput no yes
GTPBA_HUMAN [view interactions] High throughput no yes
MKLN1_HUMAN [view entry] [view interactions] High throughput yes yes
SYHM_HUMAN [view entry] [view interactions] High throughput yes yes
MCCA_HUMAN [view entry] [view interactions] High throughput yes yes
OZF_HUMAN [view interactions] High throughput no yes
LONP2_HUMAN [view interactions] High throughput no yes
EFGM_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
TES_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
NR2C2_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
TIA1_HUMAN [view interactions] High throughput no no
BIRC3_HUMAN [view interactions] High throughput no no
TIF1B_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
DIRA1_HUMAN [view entry] [view interactions] High throughput yes no
MAEA_HUMAN [view interactions] High throughput no yes
NXPH1_HUMAN [view interactions] High throughput no no
SPRTN_HUMAN [view interactions] High throughput no yes
ZFYV1_HUMAN [view interactions] High throughput no yes
FBXW7_HUMAN [view interactions] High throughput no yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
SAR1B_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
CCNF_HUMAN [view interactions] High throughput no no
VIGLN_HUMAN [view entry] [view interactions] High throughput yes yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
UBP48_HUMAN [view interactions] High throughput no yes
FND3A_HUMAN [view interactions] High throughput no yes
EZH2_HUMAN [view interactions] High throughput no no
CL16A_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
SDHA_HUMAN [view interactions] High throughput no yes
GRHPR_HUMAN [view entry] [view interactions] High throughput yes no
NIT2_HUMAN [view interactions] High throughput no yes
SCOT1_HUMAN [view entry] [view interactions] High throughput yes yes
HPDL_HUMAN [view interactions] High throughput no no
S10AG_HUMAN [view interactions] High throughput no no
SC22B_HUMAN [view entry] [view interactions] High throughput yes no
RIR1_HUMAN [view entry] [view interactions] High throughput yes yes
NAKD2_HUMAN [view interactions] High throughput no yes
RM12_HUMAN [view interactions] High throughput no yes
RBM4_HUMAN [view interactions] High throughput no yes
AGFG1_HUMAN [view interactions] High throughput no yes
IDH3A_HUMAN [view entry] [view interactions] High throughput yes yes
ODO2_HUMAN [view entry] [view interactions] High throughput yes yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
SSRD_HUMAN [view interactions] High throughput no yes
ACADM_HUMAN [view interactions] High throughput no yes
ETFA_HUMAN [view interactions] High throughput no yes
NFS1_HUMAN [view interactions] High throughput no yes
PRS7_HUMAN [view interactions] High throughput no yes
SDHB_HUMAN [view interactions] High throughput no yes
SH3L3_HUMAN [view interactions] High throughput no no
GRPE1_HUMAN [view interactions] High throughput no yes
ADRO_HUMAN [view interactions] High throughput no no
FUMH_HUMAN [view entry] [view interactions] High throughput yes yes
STXB1_HUMAN [view entry] [view interactions] High throughput yes yes
UCHL1_HUMAN [view entry] [view interactions] High throughput yes yes
SYYM_HUMAN [view interactions] High throughput no no
ABHDA_HUMAN [view interactions] High throughput no yes
PPA6_HUMAN [view interactions] High throughput no no
ANXA5_HUMAN [view entry] [view interactions] High throughput yes no
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
HTRA2_HUMAN [view interactions] High throughput no yes
PLGT3_HUMAN [view interactions] High throughput no no
MDHC_HUMAN [view entry] [view interactions] High throughput yes yes
NNRE_HUMAN [view interactions] High throughput no yes
PREP_HUMAN [view interactions] High throughput no yes
MPPA_HUMAN [view interactions] High throughput no yes
MPPB_HUMAN [view interactions] High throughput no yes