SYHM_HUMAN
Evidence for PS localization
Functions
Mitochondrial aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of histidine to the 3-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SYHM_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 45.9459 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 27.0270 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 27.0270 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.0270 | 4 | yes |
| GO:0005524 | ATP binding | 16.2162 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 16.2162 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 16.2162 | 5 | yes |
| GO:0004812 | aminoacyl-tRNA ligase activity | 5.4054 | 4 | yes |
| GO:0004821 | histidine-tRNA ligase activity | 5.4054 | 5 | yes |
| GO:0140101 | catalytic activity, acting on a tRNA | 5.4054 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SYHM_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 45.9459 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 45.9459 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 45.9459 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 45.9459 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 43.2432 | 4 | no |
| GO:0022607 | cellular component assembly | 40.5405 | 4 | no |
| GO:0010468 | regulation of gene expression | 40.5405 | 5 | no |
| GO:0006996 | organelle organization | 37.8378 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 35.1351 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 35.1351 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 35.1351 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 35.1351 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 35.1351 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 32.4324 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 32.4324 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 32.4324 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 29.7297 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 29.7297 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 27.0270 | 5 | no |
| GO:0043933 | protein-containing complex organization | 27.0270 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.0270 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 27.0270 | 5 | no |
| GO:0019752 | carboxylic acid metabolic process | 24.3243 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 24.3243 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 24.3243 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 24.3243 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 24.3243 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 24.3243 | 5 | no |
| GO:0008104 | protein localization | 24.3243 | 4 | no |
| GO:0090304 | nucleic acid metabolic process | 21.6216 | 4 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 21.6216 | 6 | no |
| GO:0010941 | regulation of cell death | 21.6216 | 4 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 21.6216 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 21.6216 | 6 | no |
| GO:0007010 | cytoskeleton organization | 21.6216 | 5 | no |
| GO:0009894 | regulation of catabolic process | 21.6216 | 4 | no |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 18.9189 | 4 | yes |
| GO:0016070 | RNA metabolic process | 16.2162 | 5 | yes |
| GO:0043603 | cellular amide metabolic process | 16.2162 | 4 | yes |
| GO:1901566 | organonitrogen compound biosynthetic process | 16.2162 | 4 | yes |
| GO:0009059 | macromolecule biosynthetic process | 13.5135 | 4 | yes |
| GO:0034645 | cellular macromolecule biosynthetic process | 10.8108 | 4 | yes |
| GO:0043604 | amide biosynthetic process | 10.8108 | 5 | yes |
| GO:0006412 | translation | 8.1081 | 4 | yes |
| GO:0006518 | peptide metabolic process | 8.1081 | 4 | yes |
| GO:0034660 | ncRNA metabolic process | 8.1081 | 6 | yes |
| GO:0043043 | peptide biosynthetic process | 8.1081 | 5 | yes |
| GO:0006399 | tRNA metabolic process | 5.4054 | 7 | yes |
| GO:0006418 | tRNA aminoacylation for protein translation | 5.4054 | 6 | yes |
| GO:0006427 | histidyl-tRNA aminoacylation | 5.4054 | 7 | yes |
| GO:0043038 | amino acid activation | 5.4054 | 4 | yes |
| GO:0043039 | tRNA aminoacylation | 5.4054 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in SYHM_HUMAN |
|---|---|---|---|---|
| DOID:700 | mitochondrial metabolism disease | 5.4054 | 3 | no |
| DOID:331 | central nervous system disease | 5.4054 | 3 | no |
| DOID:936 | brain disease | 5.4054 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SYHM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RT17_HUMAN | [view interactions] | High throughput | no | yes |
| ACSM5_HUMAN | [view interactions] | High throughput | no | yes |
| SC11C_HUMAN | [view interactions] | High throughput | no | no |
| MAGF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPOG2_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MR1L1_HUMAN | [view interactions] | High throughput | no | no |
| TROAP_HUMAN | [view interactions] | High throughput | no | yes |
| RT07_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| NTF3_HUMAN | [view interactions] | High throughput | no | no |
| KCRM_HUMAN | [view interactions] | High throughput | no | no |
| FADS1_HUMAN | [view interactions] | High throughput | no | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FITM2_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GARS_HUMAN | [view interactions] | High throughput | no | yes |
| SYSC_HUMAN | [view interactions] | High throughput | no | yes |
| SYSM_HUMAN | [view interactions] | High throughput | no | yes |
| SYNM_HUMAN | [view interactions] | High throughput | no | yes |
| SDCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPCS_HUMAN | [view interactions] | High throughput | no | no |
| MCA3_HUMAN | [view interactions] | High throughput | no | yes |
| AIMP2_HUMAN | [view interactions] | High throughput | no | yes |
| SYLC_HUMAN | [view interactions] | High throughput | no | yes |
| SYMC_HUMAN | [view interactions] | High throughput | no | yes |
| SYK_HUMAN | [view interactions] | High throughput | no | yes |
| MRM1_HUMAN | [view interactions] | High throughput | no | no |
| AUHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTRFR_HUMAN | [view interactions] | High throughput | no | yes |
| C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | yes |
| MRES1_HUMAN | [view interactions] | High throughput | no | yes |
| DDX28_HUMAN | [view interactions] | High throughput | no | yes |
| DHX30_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAKD2_HUMAN | [view interactions] | High throughput | no | no |
| EFGM_HUMAN | [view interactions] | High throughput | no | yes |
| HINT2_HUMAN | [view interactions] | High throughput | no | yes |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET17_HUMAN | [view interactions] | High throughput | no | yes |
| RM11_HUMAN | [view interactions] | High throughput | no | yes |
| RRFM_HUMAN | [view interactions] | High throughput | no | yes |
| MTEF3_HUMAN | [view interactions] | High throughput | no | no |
| IF2M_HUMAN | [view interactions] | High throughput | no | yes |
| IF3M_HUMAN | [view interactions] | High throughput | no | yes |
| RF1M_HUMAN | [view interactions] | High throughput | no | yes |
| RF1ML_HUMAN | [view interactions] | High throughput | no | yes |
| MPPB_HUMAN | [view interactions] | High throughput | no | yes |
| SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| TFAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRUB2_HUMAN | [view interactions] | High throughput | no | yes |
| EFTS_HUMAN | [view interactions] | High throughput | no | no |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| SYAM_HUMAN | [view interactions] | High throughput | no | yes |
| COX8A_HUMAN | [view interactions] | High throughput | no | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ICT1_HUMAN | [view interactions] | High throughput | no | yes |
| AURKA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VPS16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TF2H5_HUMAN | [view interactions] | High throughput | no | no |
| ORC1_HUMAN | [view interactions] | High throughput | no | yes |
| F174A_HUMAN | [view interactions] | High throughput | no | yes |
| F167A_HUMAN | [view interactions] | High throughput | no | yes |
| DKKL1_HUMAN | [view interactions] | High throughput | no | no |
| CD79A_HUMAN | [view interactions] | High throughput | no | no |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| OTC_HUMAN | [view interactions] | High throughput | no | no |
| YBEY_HUMAN | [view interactions] | High throughput | no | yes |
| RM12_HUMAN | [view interactions] | High throughput | no | yes |
| RM21_HUMAN | [view interactions] | High throughput | no | no |
| NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| SDHB_HUMAN | [view interactions] | High throughput | no | yes |
| HARS1_HUMAN | [view interactions] | High throughput | no | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADCK5_HUMAN | [view interactions] | High throughput | no | yes |
| LYRM4_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| BST2_HUMAN | [view interactions] | High throughput | no | yes |
| ATRAP_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDK1_HUMAN | [view interactions] | High throughput | no | yes |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| PARL_HUMAN | [view interactions] | High throughput | no | yes |
| GRSF1_HUMAN | [view interactions] | High throughput | no | yes |
| FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| SUCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PMEL_HUMAN | [view interactions] | High throughput | no | no |
| GORS1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| HCST_HUMAN | [view interactions] | High throughput | no | no |
| RM23_HUMAN | [view interactions] | High throughput | no | yes |
| SPRY7_HUMAN | [view interactions] | High throughput | no | yes |
| NAA30_HUMAN | [view interactions] | High throughput | no | no |
| LMNB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THEM5_HUMAN | [view interactions] | High throughput | no | no |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PO210_HUMAN | [view interactions] | High throughput | no | yes |
| ATPD_HUMAN | [view interactions] | High throughput | no | yes |
| HDBP1_HUMAN | [view interactions] | High throughput | no | no |
| NRBP_HUMAN | [view interactions] | High throughput | no | yes |
| OSTM1_HUMAN | [view interactions] | High throughput | no | yes |
| PDP1_HUMAN | [view interactions] | High throughput | no | yes |
| PFD5_HUMAN | [view interactions] | High throughput | no | yes |
| RL35A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MASU1_HUMAN | [view interactions] | High throughput | no | yes |
| F217B_HUMAN | [view interactions] | High throughput | no | yes |
| PAIRB_HUMAN | [view interactions] | High throughput | no | yes |
| ACOT6_HUMAN | [view interactions] | High throughput | no | no |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| CD003_HUMAN | [view interactions] | High throughput | no | yes |
| SPEB_HUMAN | [view interactions] | High throughput | no | no |
| DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CA210_HUMAN | [view interactions] | High throughput | no | yes |
| NSMA_HUMAN | [view interactions] | High throughput | no | yes |
| PSF2_HUMAN | [view interactions] | High throughput | no | no |
| LRC25_HUMAN | [view interactions] | High throughput | no | yes |
| NUD13_HUMAN | [view interactions] | High throughput | no | no |
| PDYN_HUMAN | [view interactions] | High throughput | no | yes |
| CND3_HUMAN | [view interactions] | High throughput | no | yes |
| FADS3_HUMAN | [view interactions] | High throughput | no | no |
| TRML2_HUMAN | [view interactions] | High throughput | no | no |
| DGAT2_HUMAN | [view interactions] | High throughput | no | no |
| ASTRB_HUMAN | [view interactions] | High throughput | no | yes |
| RUSD4_HUMAN | [view interactions] | High throughput | no | yes |
| DHB13_HUMAN | [view interactions] | High throughput | no | yes |
| PDLI5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SEP11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTG2_HUMAN | [view interactions] | High throughput | no | yes |
| AKP13_HUMAN | [view interactions] | High throughput | no | yes |
| YIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| GPX8_HUMAN | [view interactions] | High throughput | no | no |
| IMP3_HUMAN | [view interactions] | High throughput | no | no |
| KRR1_HUMAN | [view interactions] | High throughput | no | yes |
| NUDT9_HUMAN | [view interactions] | High throughput | no | yes |
| ICE2_HUMAN | [view interactions] | High throughput | no | no |
| MYLK4_HUMAN | [view interactions] | High throughput | no | no |
| STA5B_HUMAN | [view interactions] | High throughput | no | yes |
| SERC2_HUMAN | [view interactions] | High throughput | no | yes |
| THIM_HUMAN | [view interactions] | High throughput | no | yes |
| PHF7_HUMAN | [view interactions] | High throughput | no | no |
| FAHD1_HUMAN | [view interactions] | High throughput | no | yes |
| FACC1_HUMAN | [view interactions] | High throughput | no | no |
| AMACR_HUMAN | [view interactions] | High throughput | no | yes |
| KLH17_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IL1R2_HUMAN | [view interactions] | High throughput | no | no |
| DHB8_HUMAN | [view interactions] | High throughput | no | yes |
| CBCO1_HUMAN | [view interactions] | High throughput | no | no |
| SRARP_HUMAN | [view interactions] | High throughput | no | no |
| TFDP2_HUMAN | [view interactions] | High throughput | no | yes |
| MFS11_HUMAN | [view interactions] | High throughput | no | yes |
| SYIC_HUMAN | [view interactions] | Computational | no | yes |
| SYEP_HUMAN | [view interactions] | Computational | no | yes |
| SYTC2_HUMAN | [view interactions] | Computational | no | yes |
| SYYM_HUMAN | [view interactions] | Computational | no | no |
| SYYC_HUMAN | [view interactions] | Computational | no | yes |
| SYNC_HUMAN | [view interactions] | Computational | no | yes |
| IF2A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SYAC_HUMAN | [view interactions] | Computational | no | yes |
| SYTM_HUMAN | [view interactions] | Computational | no | yes |