MAGF1_HUMAN
Evidence for PS localization
Functions
Enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin ligases. Proposed to act through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. MAGEF1-NSMCE1 ubiquitin ligase complex promotes proteasomal degradation of MMS19, a key component of the cytosolic iron-sulfur protein assembly (CIA) machinery. Down-regulation of MMS19 impairs the activity of several DNA repair and metabolism enzymes such as ERCC2/XPD, FANCJ, RTEL1 and POLD1 that require iron-sulfur clusters as cofactors. May negatively regulate genome integrity by inhibiting homologous recombination-mediated double-strand break DNA repair (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MAGF1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 40.0000 | 4 | no |
| GO:0043169 | cation binding | 40.0000 | 4 | no |
| GO:0046872 | metal ion binding | 40.0000 | 5 | no |
| GO:0000166 | nucleotide binding | 30.0000 | 4 | no |
| GO:0003723 | RNA binding | 30.0000 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MAGF1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 40.0000 | 7 | yes |
| GO:0009889 | regulation of biosynthetic process | 40.0000 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 40.0000 | 4 | yes |
| GO:0010468 | regulation of gene expression | 40.0000 | 6 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 40.0000 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.0000 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 40.0000 | 5 | yes |
| GO:0031323 | regulation of cellular metabolic process | 40.0000 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 40.0000 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 40.0000 | 4 | yes |
| GO:0051252 | regulation of RNA metabolic process | 40.0000 | 5 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 40.0000 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 40.0000 | 4 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 40.0000 | 6 | yes |
| GO:0006357 | regulation of transcription by RNA polymerase II | 30.0000 | 8 | yes |
| GO:0036211 | protein modification process | 30.0000 | 4 | yes |
| GO:0043412 | macromolecule modification | 30.0000 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 30.0000 | 5 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 30.0000 | 6 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 30.0000 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 30.0000 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.0000 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 30.0000 | 6 | no |
| GO:0045893 | positive regulation of DNA-templated transcription | 30.0000 | 8 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 30.0000 | 5 | no |
| GO:0051254 | positive regulation of RNA metabolic process | 30.0000 | 6 | no |
| GO:0060341 | regulation of cellular localization | 30.0000 | 4 | no |
| GO:1902680 | positive regulation of RNA biosynthetic process | 30.0000 | 7 | no |
| GO:0022607 | cellular component assembly | 30.0000 | 4 | no |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | 20.0000 | 9 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 20.0000 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 20.0000 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 20.0000 | 4 | yes |
| GO:0009896 | positive regulation of catabolic process | 20.0000 | 5 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 20.0000 | 6 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 20.0000 | 5 | yes |
| GO:0030162 | regulation of proteolysis | 20.0000 | 6 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 20.0000 | 5 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 20.0000 | 6 | yes |
| GO:0032446 | protein modification by small protein conjugation | 20.0000 | 7 | yes |
| GO:0043687 | post-translational protein modification | 20.0000 | 5 | yes |
| GO:0045862 | positive regulation of proteolysis | 20.0000 | 7 | yes |
| GO:0045892 | negative regulation of DNA-templated transcription | 20.0000 | 8 | yes |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 20.0000 | 5 | yes |
| GO:0051253 | negative regulation of RNA metabolic process | 20.0000 | 6 | yes |
| GO:0070647 | protein modification by small protein conjugation or removal | 20.0000 | 6 | yes |
| GO:1902679 | negative regulation of RNA biosynthetic process | 20.0000 | 7 | yes |
| GO:1903050 | regulation of proteolysis involved in protein catabolic process | 20.0000 | 7 | yes |
| GO:1903052 | positive regulation of proteolysis involved in protein catabolic process | 20.0000 | 8 | yes |
| GO:2000058 | regulation of ubiquitin-dependent protein catabolic process | 20.0000 | 5 | yes |
| GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process | 20.0000 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NSE1_HUMAN | [view interactions] | Low throughput | no | yes |
| MMS19_HUMAN | [view interactions] | Low throughput | no | yes |
| EID1_HUMAN | [view interactions] | High throughput | no | yes |
| EID2_HUMAN | [view interactions] | High throughput | no | yes |
| EID2B_HUMAN | [view interactions] | High throughput | no | no |
| TRI27_HUMAN | [view interactions] | High throughput | no | yes |
| MDFI_HUMAN | [view interactions] | High throughput | no | no |
| TRAIP_HUMAN | [view interactions] | High throughput | no | yes |
| PHF7_HUMAN | [view interactions] | High throughput | no | no |
| PIAS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| RM04_HUMAN | [view interactions] | High throughput | no | yes |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| METK2_HUMAN | [view interactions] | High throughput | no | no |
| PPM1G_HUMAN | [view interactions] | High throughput | no | no |
| LHPL2_HUMAN | [view interactions] | High throughput | no | no |
| FRIL_HUMAN | [view interactions] | High throughput | no | yes |
| MYPT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MPI_HUMAN | [view interactions] | High throughput | no | yes |
| FTO_HUMAN | [view interactions] | High throughput | no | yes |
| ECHD1_HUMAN | [view interactions] | High throughput | no | no |
| IMB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PYGM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SMHD1_HUMAN | [view interactions] | High throughput | no | yes |
| SYHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDI2_HUMAN | [view interactions] | High throughput | no | no |
| P63_HUMAN | [view interactions] | High throughput | no | no |