MAGF1_HUMAN
Enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin ligases. Proposed to act through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. MAGEF1-NSMCE1 ubiquitin ligase complex promotes proteasomal degradation of MMS19, a key component of the cytosolic iron-sulfur protein assembly (CIA) machinery. Down-regulation of MMS19 impairs the activity of several DNA repair and metabolism enzymes such as ERCC2/XPD, FANCJ, RTEL1 and POLD1 that require iron-sulfur clusters as cofactors. May negatively regulate genome integrity by inhibiting homologous recombination-mediated double-strand break DNA repair (PubMed). [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in MAGF1_HUMAN |
---|---|---|---|---|
GO:0003723 | RNA binding | 33.3333 | 4 | no |
GO:0046872 | metal ion binding | 33.3333 | 4 | no |
GO:0017076 | purine nucleotide binding | 22.2222 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 22.2222 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 22.2222 | 4 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in MAGF1_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 55.5556 | 4 | yes |
GO:0006355 | regulation of DNA-templated transcription | 33.3333 | 6 | yes |
GO:0009889 | regulation of biosynthetic process | 33.3333 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | yes |
GO:0010468 | regulation of gene expression | 33.3333 | 5 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 33.3333 | 5 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | yes |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 33.3333 | 5 | yes |
GO:0031323 | regulation of cellular metabolic process | 33.3333 | 4 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 33.3333 | 5 | yes |
GO:0031326 | regulation of cellular biosynthetic process | 33.3333 | 5 | yes |
GO:0048523 | negative regulation of cellular process | 33.3333 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 33.3333 | 4 | yes |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 33.3333 | 5 | yes |
GO:0051252 | regulation of RNA metabolic process | 33.3333 | 5 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 33.3333 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 33.3333 | 4 | yes |
GO:1903506 | regulation of nucleic acid-templated transcription | 33.3333 | 7 | yes |
GO:2001141 | regulation of RNA biosynthetic process | 33.3333 | 6 | yes |
GO:0044271 | cellular nitrogen compound biosynthetic process | 33.3333 | 4 | no |
GO:0006357 | regulation of transcription by RNA polymerase II | 22.2222 | 7 | yes |
GO:0036211 | protein modification process | 22.2222 | 4 | yes |
GO:0043412 | macromolecule modification | 22.2222 | 4 | yes |
GO:0051246 | regulation of protein metabolic process | 22.2222 | 5 | yes |
GO:0051247 | positive regulation of protein metabolic process | 22.2222 | 6 | yes |
GO:0006996 | organelle organization | 22.2222 | 4 | no |
GO:0007264 | small GTPase mediated signal transduction | 22.2222 | 4 | no |
GO:0007265 | Ras protein signal transduction | 22.2222 | 5 | no |
GO:0008104 | protein localization | 22.2222 | 4 | no |
GO:0022607 | cellular component assembly | 22.2222 | 4 | no |
GO:0033365 | protein localization to organelle | 22.2222 | 5 | no |
GO:0009891 | positive regulation of biosynthetic process | 22.2222 | 5 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 22.2222 | 6 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 22.2222 | 6 | no |
GO:0045893 | positive regulation of DNA-templated transcription | 22.2222 | 7 | no |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 22.2222 | 6 | no |
GO:0051049 | regulation of transport | 22.2222 | 4 | no |
GO:0051254 | positive regulation of RNA metabolic process | 22.2222 | 6 | no |
GO:0060341 | regulation of cellular localization | 22.2222 | 4 | no |
GO:1902680 | positive regulation of RNA biosynthetic process | 22.2222 | 7 | no |
GO:1903508 | positive regulation of nucleic acid-templated transcription | 22.2222 | 8 | no |
GO:0006518 | peptide metabolic process | 22.2222 | 4 | no |
GO:0009057 | macromolecule catabolic process | 22.2222 | 4 | no |
GO:0043603 | cellular amide metabolic process | 22.2222 | 4 | no |
GO:0009059 | macromolecule biosynthetic process | 22.2222 | 4 | no |
GO:0016070 | RNA metabolic process | 22.2222 | 5 | no |
GO:0090304 | nucleic acid metabolic process | 22.2222 | 4 | no |
GO:1901566 | organonitrogen compound biosynthetic process | 22.2222 | 4 | no |
GO:0051128 | regulation of cellular component organization | 22.2222 | 4 | no |
GO:0018130 | heterocycle biosynthetic process | 22.2222 | 4 | no |
GO:0019438 | aromatic compound biosynthetic process | 22.2222 | 4 | no |
GO:1901362 | organic cyclic compound biosynthetic process | 22.2222 | 4 | no |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
NSE1_HUMAN | [view interactions] | Low throughput | no | yes |
MMS19_HUMAN | [view interactions] | Low throughput | no | yes |
EID1_HUMAN | [view interactions] | High throughput | no | yes |
EID2_HUMAN | [view interactions] | High throughput | no | yes |
EID2B_HUMAN | [view interactions] | High throughput | no | no |
TRI27_HUMAN | [view interactions] | High throughput | no | yes |
MDFI_HUMAN | [view interactions] | High throughput | no | no |
TRAIP_HUMAN | [view interactions] | High throughput | no | yes |
PHF7_HUMAN | [view interactions] | High throughput | no | no |
PIAS1_HUMAN | [view interactions] | High throughput | no | yes |
FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
RM04_HUMAN | [view interactions] | High throughput | no | yes |
PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TFAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TPP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
METK2_HUMAN | [view interactions] | High throughput | no | no |
PPM1G_HUMAN | [view interactions] | High throughput | no | no |
LHPL2_HUMAN | [view interactions] | High throughput | no | no |
FRIL_HUMAN | [view interactions] | High throughput | no | yes |
MYPT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MPI_HUMAN | [view interactions] | High throughput | no | yes |
FTO_HUMAN | [view interactions] | High throughput | no | yes |
ECHD1_HUMAN | [view interactions] | High throughput | no | no |
IMB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PYGM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SMHD1_HUMAN | [view interactions] | High throughput | no | yes |
SYHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DDI2_HUMAN | [view interactions] | High throughput | no | no |
P63_HUMAN | [view interactions] | High throughput | no | no |