TFAM_HUMAN
Evidence for PS localization
Functions
Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation (PubMed, PubMed). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed). Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase (PubMed). Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites (PubMed). Is able to unwind DNA (PubMed). Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes (PubMed). Required for maintenance of normal levels of mitochondrial DNA (PubMed, PubMed). May play a role in organizing and compacting mitochondrial DNA (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 178 | Pro | Leu | MitochondrialDNAdepletionsyndrome15,hepatocerebraltype(MTDPS15) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in TFAM_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 34.2857 | 4 | no |
| GO:0043168 | anion binding | 34.2857 | 4 | no |
| GO:0017076 | purine nucleotide binding | 33.3333 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 29.5238 | 4 | no |
| GO:0043169 | cation binding | 29.5238 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 27.6190 | 6 | no |
| GO:0046872 | metal ion binding | 27.6190 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.6667 | 4 | no |
| GO:0003723 | RNA binding | 23.8095 | 4 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 23.8095 | 5 | no |
| GO:0005524 | ATP binding | 20.9524 | 5 | no |
| GO:0003677 | DNA binding | 8.5714 | 4 | yes |
| GO:0043565 | sequence-specific DNA binding | 5.7143 | 5 | yes |
| GO:0001221 | transcription coregulator binding | 4.7619 | 4 | yes |
| GO:0003690 | double-stranded DNA binding | 4.7619 | 5 | yes |
| GO:1990837 | sequence-specific double-stranded DNA binding | 4.7619 | 6 | yes |
| GO:0000976 | transcription cis-regulatory region binding | 3.8095 | 5 | yes |
| GO:0001067 | transcription regulatory region nucleic acid binding | 3.8095 | 4 | yes |
| GO:0001223 | transcription coactivator binding | 2.8571 | 5 | yes |
| GO:0001018 | mitochondrial promoter sequence-specific DNA binding | 1.9048 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in TFAM_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 39.0476 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 38.0952 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 37.1429 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 37.1429 | 4 | yes |
| GO:0022607 | cellular component assembly | 35.2381 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 35.2381 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 32.3810 | 4 | no |
| GO:0010646 | regulation of cell communication | 32.3810 | 4 | no |
| GO:0043933 | protein-containing complex organization | 29.5238 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 29.5238 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 28.5714 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 28.5714 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 27.6190 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 27.6190 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 27.6190 | 4 | yes |
| GO:0010468 | regulation of gene expression | 27.6190 | 6 | yes |
| GO:0006996 | organelle organization | 26.6667 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.7143 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.7143 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 25.7143 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 24.7619 | 5 | yes |
| GO:1901362 | organic cyclic compound biosynthetic process | 24.7619 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 24.7619 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 23.8095 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 22.8571 | 4 | no |
| GO:1901566 | organonitrogen compound biosynthetic process | 22.8571 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 21.9048 | 5 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 20.9524 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 20.9524 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 20.9524 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 20.9524 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 20.9524 | 5 | no |
| GO:0043436 | oxoacid metabolic process | 20.9524 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 20.9524 | 5 | no |
| GO:0072521 | purine-containing compound metabolic process | 20.9524 | 4 | no |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 20.0000 | 4 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 20.0000 | 6 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 20.0000 | 7 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 19.0476 | 6 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 19.0476 | 5 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 18.0952 | 6 | yes |
| GO:0090304 | nucleic acid metabolic process | 16.1905 | 4 | yes |
| GO:0009059 | macromolecule biosynthetic process | 16.1905 | 4 | yes |
| GO:0016070 | RNA metabolic process | 12.3810 | 5 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 12.3810 | 5 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 11.4286 | 8 | yes |
| GO:0051254 | positive regulation of RNA metabolic process | 11.4286 | 6 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 11.4286 | 7 | yes |
| GO:0033108 | mitochondrial respiratory chain complex assembly | 9.5238 | 6 | yes |
| GO:0036293 | response to decreased oxygen levels | 6.6667 | 4 | yes |
| GO:0141187 | nucleic acid biosynthetic process | 5.7143 | 5 | yes |
| GO:0032774 | RNA biosynthetic process | 4.7619 | 5 | yes |
| GO:0000959 | mitochondrial RNA metabolic process | 3.8095 | 6 | yes |
| GO:0006351 | DNA-templated transcription | 3.8095 | 6 | yes |
| GO:0006352 | DNA-templated transcription initiation | 1.9048 | 6 | yes |
| GO:0006390 | mitochondrial transcription | 1.9048 | 7 | yes |
| GO:0006391 | transcription initiation at mitochondrial promoter | 1.9048 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TFAM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| C1QBP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TFB1M_HUMAN | [view interactions] | Low throughput | no | yes |
| TFB2M_HUMAN | [view interactions] | Low throughput | no | no |
| RPOM_HUMAN | [view interactions] | Low throughput | no | yes |
| CGAS_HUMAN | [view interactions] | Low throughput | no | yes |
| LONM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RM23_HUMAN | [view interactions] | High throughput | no | yes |
| MGME1_HUMAN | [view interactions] | High throughput | no | yes |
| RM35_HUMAN | [view interactions] | High throughput | no | no |
| MMAB_HUMAN | [view interactions] | High throughput | no | yes |
| RM38_HUMAN | [view interactions] | High throughput | no | yes |
| MRM3_HUMAN | [view interactions] | High throughput | no | yes |
| RM39_HUMAN | [view interactions] | High throughput | no | yes |
| RM01_HUMAN | [view interactions] | High throughput | no | yes |
| RM41_HUMAN | [view interactions] | High throughput | no | yes |
| RM10_HUMAN | [view interactions] | High throughput | no | yes |
| RM43_HUMAN | [view interactions] | High throughput | no | no |
| RM12_HUMAN | [view interactions] | High throughput | no | yes |
| RM49_HUMAN | [view interactions] | High throughput | no | yes |
| RM19_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| RM20_HUMAN | [view interactions] | High throughput | no | yes |
| H33_HUMAN | [view interactions] | High throughput | no | yes |
| RM21_HUMAN | [view interactions] | High throughput | no | no |
| RT02_HUMAN | [view interactions] | High throughput | no | no |
| RM24_HUMAN | [view interactions] | High throughput | no | yes |
| ERAL1_HUMAN | [view interactions] | High throughput | no | yes |
| RM28_HUMAN | [view interactions] | High throughput | no | yes |
| DPOG1_HUMAN | [view interactions] | High throughput | no | yes |
| RM37_HUMAN | [view interactions] | High throughput | no | yes |
| QCR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM40_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RM42_HUMAN | [view interactions] | High throughput | no | yes |
| RM44_HUMAN | [view interactions] | High throughput | no | yes |
| ATD3B_HUMAN | [view interactions] | High throughput | no | yes |
| RM46_HUMAN | [view interactions] | High throughput | no | yes |
| SET_HUMAN | [view interactions] | High throughput | no | yes |
| RM47_HUMAN | [view interactions] | High throughput | no | yes |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| RM48_HUMAN | [view interactions] | High throughput | no | yes |
| AKIP_HUMAN | [view interactions] | High throughput | no | yes |
| RM50_HUMAN | [view interactions] | High throughput | no | yes |
| BET1_HUMAN | [view interactions] | High throughput | no | no |
| RM53_HUMAN | [view interactions] | High throughput | no | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM55_HUMAN | [view interactions] | High throughput | no | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RT18B_HUMAN | [view interactions] | High throughput | no | yes |
| SFXN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RT18C_HUMAN | [view interactions] | High throughput | no | yes |
| TR61B_HUMAN | [view interactions] | High throughput | no | yes |
| RT21_HUMAN | [view interactions] | High throughput | no | no |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| RT25_HUMAN | [view interactions] | High throughput | no | yes |
| IMP1L_HUMAN | [view interactions] | High throughput | no | yes |
| RT33_HUMAN | [view interactions] | High throughput | no | no |
| PARL_HUMAN | [view interactions] | High throughput | no | yes |
| KGD4_HUMAN | [view interactions] | High throughput | no | yes |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RT06_HUMAN | [view interactions] | High throughput | no | yes |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PAPD1_HUMAN | [view interactions] | High throughput | no | yes |
| ELK3_HUMAN | [view interactions] | High throughput | no | yes |
| NDUAC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ETV4_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLF12_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LHX2_HUMAN | [view interactions] | High throughput | no | no |
| NDUA6_HUMAN | [view interactions] | High throughput | no | no |
| LHX4_HUMAN | [view interactions] | High throughput | no | no |
| NDUA7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LHX8_HUMAN | [view interactions] | High throughput | no | no |
| ACPM_HUMAN | [view interactions] | High throughput | no | yes |
| NFAC4_HUMAN | [view interactions] | High throughput | no | yes |
| NDUF2_HUMAN | [view interactions] | High throughput | no | yes |
| SOX10_HUMAN | [view interactions] | High throughput | no | yes |
| NDUF4_HUMAN | [view interactions] | High throughput | no | yes |
| SOX17_HUMAN | [view interactions] | High throughput | no | no |
| NDUF5_HUMAN | [view interactions] | High throughput | no | yes |
| SOX4_HUMAN | [view interactions] | High throughput | no | yes |
| NDUF7_HUMAN | [view interactions] | High throughput | no | yes |
| STAT4_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS4_HUMAN | [view interactions] | High throughput | no | yes |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| NDUS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VGFR1_HUMAN | [view interactions] | High throughput | no | no |
| NDUS8_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CO8A2_HUMAN | [view interactions] | High throughput | no | no |
| NDUV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUV3_HUMAN | [view interactions] | High throughput | no | yes |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| NFS1_HUMAN | [view interactions] | High throughput | no | yes |
| GRSF1_HUMAN | [view interactions] | High throughput | no | yes |
| NDKM_HUMAN | [view interactions] | High throughput | no | yes |
| NEDD1_HUMAN | [view interactions] | High throughput | no | yes |
| ODO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PDE12_HUMAN | [view interactions] | High throughput | no | yes |
| FBW1B_HUMAN | [view interactions] | High throughput | no | yes |
| PDK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| PNPT1_HUMAN | [view interactions] | High throughput | no | yes |
| SUZ12_HUMAN | [view interactions] | High throughput | no | no |
| PDIP2_HUMAN | [view interactions] | High throughput | no | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| IPYR2_HUMAN | [view interactions] | High throughput | no | yes |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| PPIF_HUMAN | [view interactions] | High throughput | no | no |
| KCD17_HUMAN | [view interactions] | High throughput | no | yes |
| P5CR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KS6B2_HUMAN | [view interactions] | High throughput | no | yes |
| P5CR2_HUMAN | [view interactions] | High throughput | no | yes |
| NFAC2_HUMAN | [view interactions] | High throughput | no | yes |
| GATA_HUMAN | [view interactions] | High throughput | no | yes |
| NKX21_HUMAN | [view interactions] | High throughput | no | no |
| RT4I1_HUMAN | [view interactions] | High throughput | no | yes |
| CC14B_HUMAN | [view interactions] | High throughput | no | no |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOPC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SLIRP_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| SUCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUV3_HUMAN | [view interactions] | High throughput | no | yes |
| ZUP1_HUMAN | [view interactions] | High throughput | no | yes |
| TACO1_HUMAN | [view interactions] | High throughput | no | yes |
| ARI1_HUMAN | [view interactions] | High throughput | no | yes |
| THEM4_HUMAN | [view interactions] | High throughput | no | no |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| TIM44_HUMAN | [view interactions] | High throughput | no | yes |
| MEPCE_HUMAN | [view interactions] | High throughput | no | yes |
| TM10C_HUMAN | [view interactions] | High throughput | no | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| PEO1_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| SYVM_HUMAN | [view interactions] | High throughput | no | yes |
| MAGF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VWA8_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WIZ_HUMAN | [view interactions] | High throughput | no | yes |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN512_HUMAN | [view interactions] | High throughput | no | yes |
| RU17_HUMAN | [view interactions] | High throughput | no | yes |
| Z512B_HUMAN | [view interactions] | High throughput | no | yes |
| CLUA1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN644_HUMAN | [view interactions] | High throughput | no | no |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| TRUB2_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFTS_HUMAN | [view interactions] | High throughput | no | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| TIM14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| SYAM_HUMAN | [view interactions] | High throughput | no | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| COX8A_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| BRD8_HUMAN | [view interactions] | High throughput | no | yes |
| BRPF3_HUMAN | [view interactions] | High throughput | no | yes |
| ZMYD8_HUMAN | [view interactions] | High throughput | no | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| MAFB_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| CIC_HUMAN | [view interactions] | High throughput | no | yes |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3F_HUMAN | [view interactions] | High throughput | no | yes |
| REXO4_HUMAN | [view interactions] | High throughput | no | yes |
| REPI1_HUMAN | [view interactions] | High throughput | no | yes |
| RL35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIFC1_HUMAN | [view interactions] | High throughput | no | yes |
| KRR1_HUMAN | [view interactions] | High throughput | no | yes |
| WDR46_HUMAN | [view interactions] | High throughput | no | yes |
| BAZ1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSF1_HUMAN | [view interactions] | High throughput | no | yes |
| NOG2_HUMAN | [view interactions] | High throughput | no | yes |
| RRP1B_HUMAN | [view interactions] | High throughput | no | yes |
| DDX18_HUMAN | [view interactions] | High throughput | no | yes |
| RL7L_HUMAN | [view interactions] | High throughput | no | no |
| RRP12_HUMAN | [view interactions] | High throughput | no | no |
| SMCA5_HUMAN | [view interactions] | High throughput | no | yes |
| NUSAP_HUMAN | [view interactions] | High throughput | no | no |
| ZBT24_HUMAN | [view interactions] | High throughput | no | no |
| H2B1C_HUMAN | [view interactions] | High throughput | no | yes |
| CEBPZ_HUMAN | [view interactions] | High throughput | no | no |
| RBM28_HUMAN | [view interactions] | High throughput | no | yes |
| TSYL1_HUMAN | [view interactions] | High throughput | no | yes |
| H13_HUMAN | [view interactions] | High throughput | no | no |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| M4K2_HUMAN | [view interactions] | High throughput | no | yes |
| ZBTB2_HUMAN | [view interactions] | High throughput | no | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| CATL1_HUMAN | [view interactions] | High throughput | no | yes |
| FURIN_HUMAN | [view interactions] | High throughput | no | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| TM11B_HUMAN | [view interactions] | High throughput | no | no |
| CLC4D_HUMAN | [view interactions] | High throughput | no | no |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| BRD3_HUMAN | [view interactions] | High throughput | no | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTMA_HUMAN | [view interactions] | High throughput | no | yes |
| FOXA1_HUMAN | [view interactions] | High throughput | no | no |
| MYCN_HUMAN | [view interactions] | High throughput | no | no |
| E2F4_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| DOT1L_HUMAN | [view interactions] | High throughput | no | yes |
| MEN1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SMC5_HUMAN | [view interactions] | High throughput | no | yes |
| GRM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAT6A_HUMAN | [view interactions] | High throughput | no | yes |
| B3GN2_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| TPRX1_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| ICT1_HUMAN | [view interactions] | High throughput | no | yes |
| AN34C_HUMAN | [view interactions] | High throughput | no | no |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFIX_HUMAN | [view interactions] | High throughput | no | no |
| COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FL2D_HUMAN | [view interactions] | High throughput | no | yes |
| COX5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| COX6C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELK1_HUMAN | [view interactions] | High throughput | no | yes |
| COX7C_HUMAN | [view interactions] | High throughput | no | yes |
| RHG23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| CY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRF_HUMAN | [view interactions] | High throughput | no | yes |
| ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CASP8_HUMAN | [view interactions] | High throughput | no | yes |
| ECHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| ENPL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| LACTB_HUMAN | [view interactions] | High throughput | no | yes |
| SDHA_HUMAN | [view interactions] | High throughput | no | yes |
| COX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACOT2_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPM1G_HUMAN | [view interactions] | High throughput | no | no |
| ODPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIC10_HUMAN | [view interactions] | High throughput | no | yes |
| SNF5_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ST38L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NIPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IRF2_HUMAN | [view interactions] | High throughput | no | yes |
| TOM40_HUMAN | [view interactions] | High throughput | no | yes |
| CDK1_HUMAN | [view interactions] | High throughput | no | no |
| QCR8_HUMAN | [view interactions] | High throughput | no | yes |
| BCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VDAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PNPH_HUMAN | [view interactions] | High throughput | no | no |
| HME1_HUMAN | [view interactions] | High throughput | no | no |
| EF1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLF3_HUMAN | [view interactions] | High throughput | no | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GATA4_HUMAN | [view interactions] | High throughput | no | no |
| RBBP4_HUMAN | [view interactions] | High throughput | no | yes |
| KLF16_HUMAN | [view interactions] | High throughput | no | yes |
| SAFB2_HUMAN | [view interactions] | High throughput | no | yes |
| SOX15_HUMAN | [view interactions] | High throughput | no | no |
| SAFB1_HUMAN | [view interactions] | High throughput | no | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| RBBP7_HUMAN | [view interactions] | High throughput | no | yes |
| SOX5_HUMAN | [view interactions] | High throughput | no | no |
| CH033_HUMAN | [view interactions] | High throughput | no | yes |
| SOX6_HUMAN | [view interactions] | High throughput | no | yes |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| TLX1_HUMAN | [view interactions] | High throughput | no | no |
| MRM1_HUMAN | [view interactions] | High throughput | no | no |
| TLX3_HUMAN | [view interactions] | High throughput | no | no |
| AUHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NKX25_HUMAN | [view interactions] | High throughput | no | no |
| MTRFR_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA1_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | no |
| EPHAA_HUMAN | [view interactions] | High throughput | no | yes |
| MRES1_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA2_HUMAN | [view interactions] | High throughput | no | no |
| EFGM_HUMAN | [view interactions] | High throughput | no | yes |
| EPHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HINT2_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR2_HUMAN | [view interactions] | High throughput | no | yes |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET17_HUMAN | [view interactions] | High throughput | no | yes |
| RYK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RRFM_HUMAN | [view interactions] | High throughput | no | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTEF3_HUMAN | [view interactions] | High throughput | no | no |
| CRCM_HUMAN | [view interactions] | High throughput | no | no |
| IF2M_HUMAN | [view interactions] | High throughput | no | yes |
| IKKE_HUMAN | [view interactions] | High throughput | no | yes |
| IF3M_HUMAN | [view interactions] | High throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| RF1M_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| MPPA_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| TEFM_HUMAN | [view interactions] | High throughput | no | no |
| ACAD9_HUMAN | [view interactions] | High throughput | no | yes |
| DNM1L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THIL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| ACOT1_HUMAN | [view interactions] | High throughput | no | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AFG32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| KAD4_HUMAN | [view interactions] | High throughput | no | yes |
| AR6P1_HUMAN | [view interactions] | High throughput | no | yes |
| HEM1_HUMAN | [view interactions] | High throughput | no | yes |
| ATRAP_HUMAN | [view interactions] | High throughput | no | yes |
| ANGE2_HUMAN | [view interactions] | High throughput | no | yes |
| TSN1_HUMAN | [view interactions] | High throughput | no | yes |
| ARID2_HUMAN | [view interactions] | High throughput | no | no |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPB_HUMAN | [view interactions] | High throughput | no | yes |
| STAT_HUMAN | [view interactions] | High throughput | no | no |
| AT5F1_HUMAN | [view interactions] | High throughput | no | yes |
| TECR_HUMAN | [view interactions] | High throughput | no | yes |
| ATP5H_HUMAN | [view interactions] | High throughput | no | yes |
| ATP5J_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| ATPO_HUMAN | [view interactions] | High throughput | no | yes |
| CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATPF1_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| BAZ2A_HUMAN | [view interactions] | High throughput | no | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CQ080_HUMAN | [view interactions] | High throughput | no | yes |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| FMC1_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| CH082_HUMAN | [view interactions] | High throughput | no | yes |
| ATD3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYCM_HUMAN | [view interactions] | High throughput | no | yes |
| SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DACH1_HUMAN | [view interactions] | High throughput | no | no |
| DHX30_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTCD3_HUMAN | [view interactions] | High throughput | no | yes |
| DDX50_HUMAN | [view interactions] | High throughput | no | yes |
| PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX54_HUMAN | [view interactions] | High throughput | no | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYEM_HUMAN | [view interactions] | High throughput | no | yes |
| CKAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G45IP_HUMAN | [view interactions] | High throughput | no | yes |
| ECSIT_HUMAN | [view interactions] | High throughput | no | yes |
| RT05_HUMAN | [view interactions] | High throughput | no | yes |
| EHMT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RT07_HUMAN | [view interactions] | High throughput | no | yes |
| RNZ2_HUMAN | [view interactions] | High throughput | no | yes |
| RT09_HUMAN | [view interactions] | High throughput | no | yes |
| ETFA_HUMAN | [view interactions] | High throughput | no | yes |
| RT10_HUMAN | [view interactions] | High throughput | no | yes |
| ETFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RT11_HUMAN | [view interactions] | High throughput | no | yes |
| GATB_HUMAN | [view interactions] | High throughput | no | yes |
| RT14_HUMAN | [view interactions] | High throughput | no | yes |
| GLSK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RT16_HUMAN | [view interactions] | High throughput | no | yes |
| DHE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RT17_HUMAN | [view interactions] | High throughput | no | yes |
| GRPE1_HUMAN | [view interactions] | High throughput | no | yes |
| RT22_HUMAN | [view interactions] | High throughput | no | yes |
| GTPB6_HUMAN | [view interactions] | High throughput | no | no |
| RT23_HUMAN | [view interactions] | High throughput | no | yes |
| GUF1_HUMAN | [view interactions] | High throughput | no | yes |
| RT24_HUMAN | [view interactions] | High throughput | no | yes |
| HCDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RT27_HUMAN | [view interactions] | High throughput | no | yes |
| SYHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RT29_HUMAN | [view interactions] | High throughput | no | yes |
| HMGB1_HUMAN | [view interactions] | High throughput | no | yes |
| RT31_HUMAN | [view interactions] | High throughput | no | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RT35_HUMAN | [view interactions] | High throughput | no | yes |
| HSDL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RT26_HUMAN | [view interactions] | High throughput | no | yes |
| SYIM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RT28_HUMAN | [view interactions] | High throughput | no | yes |
| CAF17_HUMAN | [view interactions] | High throughput | no | no |
| RT34_HUMAN | [view interactions] | High throughput | no | yes |
| MRPP3_HUMAN | [view interactions] | High throughput | no | yes |
| RM04_HUMAN | [view interactions] | High throughput | no | yes |
| MAN1_HUMAN | [view interactions] | High throughput | no | yes |
| RM11_HUMAN | [view interactions] | High throughput | no | yes |
| LETM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM22_HUMAN | [view interactions] | High throughput | no | yes |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM03_HUMAN | [view interactions] | High throughput | no | yes |
| LYRM4_HUMAN | [view interactions] | High throughput | no | yes |
| RM15_HUMAN | [view interactions] | High throughput | no | yes |
| MET15_HUMAN | [view interactions] | High throughput | no | no |