TIM14_HUMAN
Evidence for PS localization
Functions
Mitochondrial co-chaperone which forms a complex with prohibitins to regulate cardiolipin remodeling . May be a component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in TIM14_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 40.2778 | 4 | no |
| GO:0046872 | metal ion binding | 23.6111 | 4 | no |
| GO:0015399 | primary active transmembrane transporter activity | 20.8333 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in TIM14_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 37.5000 | 4 | no |
| GO:0022607 | cellular component assembly | 37.5000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 34.7222 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 33.3333 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 33.3333 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 33.3333 | 4 | no |
| GO:0043933 | protein-containing complex organization | 30.5556 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 30.5556 | 5 | no |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 29.1667 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 27.7778 | 4 | no |
| GO:0010468 | regulation of gene expression | 27.7778 | 5 | no |
| GO:0043603 | cellular amide metabolic process | 26.3889 | 4 | no |
| GO:1901566 | organonitrogen compound biosynthetic process | 26.3889 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 26.3889 | 4 | no |
| GO:0006996 | organelle organization | 26.3889 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 26.3889 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.3889 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 26.3889 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.0000 | 5 | no |
| GO:0009059 | macromolecule biosynthetic process | 23.6111 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 23.6111 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 23.6111 | 5 | no |
| GO:0006518 | peptide metabolic process | 22.2222 | 4 | no |
| GO:0043043 | peptide biosynthetic process | 22.2222 | 5 | no |
| GO:0043604 | amide biosynthetic process | 22.2222 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 22.2222 | 5 | no |
| GO:0071702 | organic substance transport | 20.8333 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 20.8333 | 4 | yes |
| GO:0006412 | translation | 20.8333 | 4 | no |
| GO:0034645 | cellular macromolecule biosynthetic process | 20.8333 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 20.8333 | 4 | no |
| GO:0022900 | electron transport chain | 20.8333 | 4 | no |
| GO:0022904 | respiratory electron transport chain | 20.8333 | 5 | no |
| GO:0008104 | protein localization | 19.4444 | 4 | yes |
| GO:0015031 | protein transport | 15.2778 | 4 | yes |
| GO:0006886 | intracellular protein transport | 13.8889 | 4 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 13.8889 | 6 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 13.8889 | 5 | yes |
| GO:0033365 | protein localization to organelle | 11.1111 | 5 | yes |
| GO:0072594 | establishment of protein localization to organelle | 9.7222 | 4 | yes |
| GO:0006839 | mitochondrial transport | 6.9444 | 4 | yes |
| GO:0065002 | intracellular protein transmembrane transport | 6.9444 | 4 | yes |
| GO:0070585 | protein localization to mitochondrion | 6.9444 | 6 | yes |
| GO:0072655 | establishment of protein localization to mitochondrion | 6.9444 | 5 | yes |
| GO:0019216 | regulation of lipid metabolic process | 5.5556 | 5 | yes |
| GO:0044743 | protein transmembrane import into intracellular organelle | 5.5556 | 4 | yes |
| GO:0030150 | protein import into mitochondrial matrix | 4.1667 | 4 | yes |
| GO:1900208 | regulation of cardiolipin metabolic process | 4.1667 | 7 | yes |
| GO:1903725 | regulation of phospholipid metabolic process | 4.1667 | 6 | yes |
| GO:0007600 | sensory perception | 2.7778 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in TIM14_HUMAN |
|---|---|---|---|---|
| DOID:700 | mitochondrial metabolism disease | 2.7778 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GRP75_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TIM16_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FPR1_HUMAN | [view interactions] | High throughput | no | no |
| PTH2R_HUMAN | [view interactions] | High throughput | no | no |
| AQP3_HUMAN | [view interactions] | High throughput | no | no |
| UD15_HUMAN | [view interactions] | High throughput | no | no |
| AVR2B_HUMAN | [view interactions] | High throughput | no | no |
| MAGA8_HUMAN | [view interactions] | High throughput | no | no |
| OX2R_HUMAN | [view interactions] | High throughput | no | no |
| RAMP2_HUMAN | [view interactions] | High throughput | no | no |
| GHRL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TSN15_HUMAN | [view interactions] | High throughput | no | yes |
| DOXA2_HUMAN | [view interactions] | High throughput | no | no |
| AFG32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRBP2_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SFPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SLTM_HUMAN | [view interactions] | High throughput | no | yes |
| ABCB7_HUMAN | [view interactions] | High throughput | no | yes |
| RM49_HUMAN | [view interactions] | High throughput | no | yes |
| COX5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| ETFA_HUMAN | [view interactions] | High throughput | no | yes |
| ETFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LETM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LG3BP_HUMAN | [view interactions] | High throughput | no | no |
| NDUA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDUS2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS4_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS8_HUMAN | [view interactions] | High throughput | no | yes |
| NDUV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL34_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS29_HUMAN | [view interactions] | High throughput | no | yes |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRP14_HUMAN | [view interactions] | High throughput | no | no |
| SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RT29_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1A_HUMAN | [view interactions] | High throughput | no | yes |
| IDD_HUMAN | [view interactions] | High throughput | no | no |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RT31_HUMAN | [view interactions] | High throughput | no | yes |
| ZNT9_HUMAN | [view interactions] | High throughput | no | yes |
| TIM44_HUMAN | [view interactions] | High throughput | no | yes |
| RT27_HUMAN | [view interactions] | High throughput | no | yes |
| NDUF3_HUMAN | [view interactions] | High throughput | no | yes |
| RT28_HUMAN | [view interactions] | High throughput | no | yes |
| RT18B_HUMAN | [view interactions] | High throughput | no | yes |
| ACAD9_HUMAN | [view interactions] | High throughput | no | yes |
| NDUF4_HUMAN | [view interactions] | High throughput | no | yes |
| RM22_HUMAN | [view interactions] | High throughput | no | yes |
| P5CR2_HUMAN | [view interactions] | High throughput | no | yes |
| STML2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RT16_HUMAN | [view interactions] | High throughput | no | yes |
| RM04_HUMAN | [view interactions] | High throughput | no | yes |
| RT07_HUMAN | [view interactions] | High throughput | no | yes |
| RT02_HUMAN | [view interactions] | High throughput | no | no |
| CHCH2_HUMAN | [view interactions] | High throughput | no | yes |
| RT23_HUMAN | [view interactions] | High throughput | no | yes |
| RM50_HUMAN | [view interactions] | High throughput | no | yes |
| TM10C_HUMAN | [view interactions] | High throughput | no | yes |
| PTCD3_HUMAN | [view interactions] | High throughput | no | yes |
| RT10_HUMAN | [view interactions] | High throughput | no | yes |
| NDUAC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RT22_HUMAN | [view interactions] | High throughput | no | yes |
| RT35_HUMAN | [view interactions] | High throughput | no | yes |
| GUF1_HUMAN | [view interactions] | High throughput | no | yes |
| RT14_HUMAN | [view interactions] | High throughput | no | yes |
| RT25_HUMAN | [view interactions] | High throughput | no | yes |
| RT26_HUMAN | [view interactions] | High throughput | no | yes |
| RT24_HUMAN | [view interactions] | High throughput | no | yes |
| RT09_HUMAN | [view interactions] | High throughput | no | yes |
| RT05_HUMAN | [view interactions] | High throughput | no | yes |
| RM44_HUMAN | [view interactions] | High throughput | no | yes |
| RT34_HUMAN | [view interactions] | High throughput | no | yes |
| RM43_HUMAN | [view interactions] | High throughput | no | no |
| NDUF2_HUMAN | [view interactions] | High throughput | no | yes |
| PTPM1_HUMAN | [view interactions] | High throughput | no | yes |
| RM53_HUMAN | [view interactions] | High throughput | no | yes |
| CAF17_HUMAN | [view interactions] | High throughput | no | no |
| RM21_HUMAN | [view interactions] | High throughput | no | no |
| NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PDE12_HUMAN | [view interactions] | High throughput | no | yes |
| RM13_HUMAN | [view interactions] | High throughput | no | yes |
| MMAB_HUMAN | [view interactions] | High throughput | no | yes |
| ICT1_HUMAN | [view interactions] | High throughput | no | yes |
| NDUV3_HUMAN | [view interactions] | High throughput | no | yes |
| NDKM_HUMAN | [view interactions] | High throughput | no | yes |
| TACO1_HUMAN | [view interactions] | High throughput | no | yes |
| ECSIT_HUMAN | [view interactions] | High throughput | no | yes |
| RT17_HUMAN | [view interactions] | High throughput | no | yes |
| CQ080_HUMAN | [view interactions] | High throughput | no | yes |
| RM20_HUMAN | [view interactions] | High throughput | no | yes |
| PEO1_HUMAN | [view interactions] | High throughput | no | yes |
| RM12_HUMAN | [view interactions] | High throughput | no | yes |
| ACOT1_HUMAN | [view interactions] | High throughput | no | yes |
| MIC60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPF1_HUMAN | [view interactions] | High throughput | no | yes |
| RT06_HUMAN | [view interactions] | High throughput | no | yes |
| TM231_HUMAN | [view interactions] | High throughput | no | yes |
| COQ5_HUMAN | [view interactions] | High throughput | no | yes |
| AP2A_HUMAN | [view interactions] | High throughput | no | no |
| TCPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX31_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LPAR4_HUMAN | [view interactions] | High throughput | no | no |
| S15A1_HUMAN | [view interactions] | High throughput | no | no |
| GTR12_HUMAN | [view interactions] | High throughput | no | yes |
| TSN5_HUMAN | [view interactions] | High throughput | no | no |
| EAA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SACA1_HUMAN | [view interactions] | High throughput | no | no |
| RNBP6_HUMAN | [view interactions] | High throughput | no | yes |
| VNN2_HUMAN | [view interactions] | High throughput | no | no |
| P2RX4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MFSD8_HUMAN | [view interactions] | High throughput | no | yes |
| MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
| MIX23_HUMAN | [view interactions] | High throughput | no | yes |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| MAIP1_HUMAN | [view interactions] | High throughput | no | yes |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| MCPH1_HUMAN | [view interactions] | High throughput | no | yes |
| TI17A_HUMAN | [view interactions] | High throughput | no | yes |
| MAGA1_HUMAN | [view interactions] | High throughput | no | no |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S39AC_HUMAN | [view interactions] | High throughput | no | no |
| SPX3_HUMAN | [view interactions] | High throughput | no | no |
| PCDGD_HUMAN | [view interactions] | High throughput | no | no |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| IPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AN32B_HUMAN | [view interactions] | High throughput | no | yes |
| YMEL1_HUMAN | [view interactions] | High throughput | no | yes |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OSBL8_HUMAN | [view interactions] | High throughput | no | yes |
| PP6R1_HUMAN | [view interactions] | High throughput | no | no |
| DICER_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUCL_HUMAN | [view interactions] | High throughput | no | yes |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPM1G_HUMAN | [view interactions] | High throughput | no | no |
| LSG1_HUMAN | [view interactions] | High throughput | no | yes |
| SYIM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEUA_HUMAN | [view interactions] | High throughput | no | yes |
| CCD47_HUMAN | [view interactions] | High throughput | no | yes |
| RCN2_HUMAN | [view interactions] | High throughput | no | yes |
| RL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL7A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL15_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL27_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RLA0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RRP1_HUMAN | [view interactions] | High throughput | no | yes |
| DCAF7_HUMAN | [view interactions] | High throughput | no | yes |
| DNMT1_HUMAN | [view interactions] | High throughput | no | no |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROA0_HUMAN | [view interactions] | High throughput | no | yes |
| RLA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| SC5A6_HUMAN | [view interactions] | High throughput | no | no |
| ABTB2_HUMAN | [view interactions] | High throughput | no | yes |
| CORO7_HUMAN | [view interactions] | High throughput | no | no |
| S22A4_HUMAN | [view interactions] | High throughput | no | yes |
| CD53_HUMAN | [view interactions] | High throughput | no | yes |
| STK36_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | Computational | no | yes |
| MPPA_HUMAN | [view interactions] | Computational | no | yes |
| TIM50_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TIM23_HUMAN | [view interactions] | Computational | no | yes |
| CH60_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GRPE1_HUMAN | [view interactions] | Computational | no | yes |
| HSP74_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TIM9_HUMAN | [view interactions] | Computational | no | yes |
| AT11B_HUMAN | [view interactions] | Computational | no | no |
| TI17B_HUMAN | [view interactions] | Computational | no | no |
| TIM10_HUMAN | [view interactions] | Computational | no | yes |
| ROMO1_HUMAN | [view interactions] | Computational | no | yes |
| GRPE2_HUMAN | [view interactions] | Computational | no | yes |
| AUHM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TOM22_HUMAN | [view interactions] | Computational | no | yes |
| TIM21_HUMAN | [view interactions] | Computational | no | yes |
| MPPB_HUMAN | [view interactions] | Computational | no | yes |