Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

COX5B_HUMAN

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. [View more on UniProt]

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No data found.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in COX5B_HUMAN
GO:0015399 primary active transmembrane transporter activity 42.4658 4 yes
GO:0015453 oxidoreduction-driven active transmembrane transporter activity 41.0959 5 yes
GO:0003954 NADH dehydrogenase activity 30.1370 4 no
GO:0003955 NAD(P)H dehydrogenase (quinone) activity 28.7671 5 no
GO:0008137 NADH dehydrogenase (ubiquinone) activity 28.7671 4 no
GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 28.7671 4 no
GO:0050136 NADH dehydrogenase (quinone) activity 28.7671 5 no
GO:0046872 metal ion binding 26.0274 4 yes
GO:0008324 cation transmembrane transporter activity 15.0685 4 yes
GO:0022853 active ion transmembrane transporter activity 15.0685 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 15.0685 4 yes
GO:0015078 proton transmembrane transporter activity 13.6986 5 yes
GO:0004129 cytochrome-c oxidase activity 8.2192 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in COX5B_HUMAN
GO:0009060 aerobic respiration 43.8356 6 yes
GO:0015980 energy derivation by oxidation of organic compounds 43.8356 4 yes
GO:0022900 electron transport chain 43.8356 4 yes
GO:0022904 respiratory electron transport chain 43.8356 5 yes
GO:0045333 cellular respiration 43.8356 5 yes
GO:0022607 cellular component assembly 42.4658 4 no
GO:0019646 aerobic electron transport chain 41.0959 6 yes
GO:0043933 protein-containing complex organization 36.9863 4 no
GO:0065003 protein-containing complex assembly 36.9863 5 no
GO:0080090 regulation of primary metabolic process 32.8767 4 no
GO:0031323 regulation of cellular metabolic process 31.5068 4 no
GO:0048522 positive regulation of cellular process 31.5068 4 no
GO:0051171 regulation of nitrogen compound metabolic process 31.5068 4 no
GO:0060255 regulation of macromolecule metabolic process 30.1370 4 no
GO:0009893 positive regulation of metabolic process 28.7671 4 no
GO:0048523 negative regulation of cellular process 27.3973 4 no
GO:0051246 regulation of protein metabolic process 27.3973 5 no
GO:0006120 mitochondrial electron transport, NADH to ubiquinone 26.0274 7 no
GO:0006996 organelle organization 24.6575 4 no
GO:0010604 positive regulation of macromolecule metabolic process 24.6575 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 24.6575 5 no
GO:0033108 mitochondrial respiratory chain complex assembly 24.6575 6 no
GO:0009892 negative regulation of metabolic process 23.2877 4 no
GO:0010646 regulation of cell communication 23.2877 4 no
GO:0010257 NADH dehydrogenase complex assembly 23.2877 6 no
GO:0032981 mitochondrial respiratory chain complex I assembly 23.2877 7 no
GO:0009889 regulation of biosynthetic process 21.9178 4 no
GO:0009966 regulation of signal transduction 21.9178 4 no
GO:0010468 regulation of gene expression 21.9178 5 no
GO:0031326 regulation of cellular biosynthetic process 21.9178 5 no
GO:0008104 protein localization 20.5479 4 no
GO:0071702 organic substance transport 20.5479 4 no
GO:0010941 regulation of cell death 20.5479 4 no
GO:0051247 positive regulation of protein metabolic process 20.5479 6 no
GO:1902531 regulation of intracellular signal transduction 20.5479 5 no
GO:0051049 regulation of transport 20.5479 4 no
GO:0006123 mitochondrial electron transport, cytochrome c to oxygen 9.5890 7 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
COX8A_HUMAN [view interactions] Low throughput no yes
COX3_HUMAN [view interactions] Low throughput no yes
COX6C_HUMAN [view entry] [view interactions] Low throughput yes yes
COX7B_HUMAN [view interactions] Low throughput no yes
CX7A2_HUMAN [view interactions] Low throughput no no
NDUA4_HUMAN [view entry] [view interactions] Low throughput yes yes
COX2_HUMAN [view entry] [view interactions] Low throughput yes yes
COX41_HUMAN [view entry] [view interactions] Low throughput yes yes
ANDR_HUMAN [view interactions] Low throughput no no
COX7C_HUMAN [view interactions] Low throughput no yes
CX6B1_HUMAN [view entry] [view interactions] Low throughput yes yes
CX6A1_HUMAN [view interactions] Low throughput no yes
COX5A_HUMAN [view entry] [view interactions] Low throughput yes yes
COX1_HUMAN [view interactions] Low throughput no yes
TRIM1_HUMAN [view interactions] High throughput no no
TRI23_HUMAN [view interactions] High throughput no yes
TASO2_HUMAN [view interactions] High throughput no yes
IHO1_HUMAN [view interactions] High throughput no no
SAV1_HUMAN [view interactions] High throughput no yes
OTUB1_HUMAN [view interactions] High throughput no yes
NDUAB_HUMAN [view interactions] High throughput no no
TIDC1_HUMAN [view interactions] High throughput no yes
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
TMED2_HUMAN [view interactions] High throughput no yes
VAPA_HUMAN [view entry] [view interactions] High throughput yes yes
YIPF5_HUMAN [view interactions] High throughput no yes
SHLD3_HUMAN [view interactions] High throughput no yes
NMES1_HUMAN [view interactions] High throughput no no
OPA3_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
AT2B4_HUMAN [view entry] [view interactions] High throughput yes yes
FANCM_HUMAN [view interactions] High throughput no no
QCR2_HUMAN [view entry] [view interactions] High throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
SP7_HUMAN [view interactions] High throughput no no
KLF16_HUMAN [view interactions] High throughput no yes
EPB41_HUMAN [view entry] [view interactions] High throughput yes no
PTBP3_HUMAN [view interactions] High throughput no no
TX101_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
CNDD3_HUMAN [view interactions] High throughput no no
BHE40_HUMAN [view interactions] High throughput no yes
K1C15_HUMAN [view interactions] High throughput no no
CDR2_HUMAN [view interactions] High throughput no yes
TRAF1_HUMAN [view interactions] High throughput no no
K1H1_HUMAN [view interactions] High throughput no no
PNMA1_HUMAN [view interactions] High throughput no yes
TFP11_HUMAN [view interactions] High throughput no no
PRDM6_HUMAN [view interactions] High throughput no no
CDR2L_HUMAN [view interactions] High throughput no yes
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
TRI27_HUMAN [view interactions] High throughput no yes
KAP1_HUMAN [view entry] [view interactions] High throughput yes yes
K1C27_HUMAN [view interactions] High throughput no no
ARI5A_HUMAN [view interactions] High throughput no yes
NUDT5_HUMAN [view interactions] High throughput no no
BORG1_HUMAN [view interactions] High throughput no yes
KT33B_HUMAN [view interactions] High throughput no no
MS18B_HUMAN [view interactions] High throughput no no
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
PKHF2_HUMAN [view interactions] High throughput no yes
RBM48_HUMAN [view interactions] High throughput no yes
TEX12_HUMAN [view interactions] High throughput no no
SLAI1_HUMAN [view interactions] High throughput no no
F228A_HUMAN [view interactions] High throughput no no
MCCD1_HUMAN [view interactions] High throughput no no
ESR1_HUMAN [view interactions] High throughput no no
CLPP_HUMAN [view interactions] High throughput no yes
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
CH60_HUMAN [view entry] [view interactions] High throughput yes yes
COX14_HUMAN [view interactions] High throughput no yes
MGST3_HUMAN [view entry] [view interactions] High throughput yes yes
PDK1_HUMAN [view interactions] High throughput no yes
SCO1_HUMAN [view interactions] High throughput no yes
IMP2L_HUMAN [view interactions] High throughput no yes
HTRA2_HUMAN [view interactions] High throughput no yes
IMP1L_HUMAN [view interactions] High throughput no yes
LACTB_HUMAN [view interactions] High throughput no yes
OMA1_HUMAN [view interactions] High throughput no no
PARL_HUMAN [view interactions] High throughput no yes
FHI2B_HUMAN [view interactions] High throughput no yes
LSM4_HUMAN [view interactions] High throughput no yes
DOK3_HUMAN [view interactions] High throughput no no
VPS28_HUMAN [view entry] [view interactions] High throughput yes yes
PPR32_HUMAN [view interactions] High throughput no no
PRR22_HUMAN [view interactions] High throughput no no
NELFD_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
STB5L_HUMAN [view interactions] High throughput no no
GLYM_HUMAN [view entry] [view interactions] High throughput yes yes
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA4_HUMAN [view interactions] High throughput no yes
EMC1_HUMAN [view interactions] High throughput no yes
EMC5_HUMAN [view interactions] High throughput no yes
KI20A_HUMAN [view interactions] High throughput no yes
PRC1_HUMAN [view interactions] High throughput no yes
DPS1_HUMAN [view interactions] High throughput no yes
2ABD_HUMAN [view interactions] High throughput no yes
ATPF2_HUMAN [view interactions] High throughput no yes
DPP9_HUMAN [view interactions] High throughput no yes
TOP3A_HUMAN [view interactions] High throughput no yes
DLP1_HUMAN [view interactions] High throughput no no
COX7R_HUMAN [view entry] [view interactions] High throughput yes no
HEM1_HUMAN [view interactions] High throughput no yes
CF062_HUMAN [view interactions] High throughput no yes
MMSA_HUMAN [view entry] [view interactions] High throughput yes no
NDUF5_HUMAN [view interactions] High throughput no yes
SPT20_HUMAN [view interactions] High throughput no yes
EPDR1_HUMAN [view interactions] High throughput no yes
COXM2_HUMAN [view interactions] High throughput no yes
COA3_HUMAN [view interactions] High throughput no yes
AUHM_HUMAN [view entry] [view interactions] High throughput yes yes
DPOG1_HUMAN [view interactions] High throughput no yes
CX7A1_HUMAN [view interactions] High throughput no no
ODB2_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS6_HUMAN [view entry] [view interactions] High throughput yes yes
CX7B2_HUMAN [view interactions] High throughput no no
FFAR1_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RTN4_HUMAN [view entry] [view interactions] High throughput yes yes
ODP2_HUMAN [view entry] [view interactions] High throughput yes yes
CHCH2_HUMAN [view interactions] High throughput no yes
AP2B1_HUMAN [view entry] [view interactions] High throughput yes yes
NDUAA_HUMAN [view entry] [view interactions] High throughput yes yes
PSMD7_HUMAN [view interactions] High throughput no yes
TOM40_HUMAN [view interactions] High throughput no yes
VAPB_HUMAN [view entry] [view interactions] High throughput yes yes
WDFY1_HUMAN [view interactions] High throughput no yes
PPIL3_HUMAN [view interactions] High throughput no yes
RLA2_HUMAN [view entry] [view interactions] High throughput yes yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
ATPB_HUMAN [view interactions] High throughput no yes
PHB2_HUMAN [view entry] [view interactions] High throughput yes yes
ATPA_HUMAN [view interactions] High throughput no yes
ECHB_HUMAN [view entry] [view interactions] High throughput yes yes
TRI14_HUMAN [view interactions] High throughput no yes
MRM1_HUMAN [view interactions] High throughput no no
GAL3A_HUMAN [view interactions] High throughput no yes
GAL3B_HUMAN [view interactions] High throughput no yes
CC90B_HUMAN [view interactions] High throughput no yes
MET17_HUMAN [view interactions] High throughput no yes
MIC26_HUMAN [view entry] [view interactions] High throughput yes yes
RMND1_HUMAN [view interactions] High throughput no yes
CMC1_HUMAN [view entry] [view interactions] High throughput yes yes
SURF1_HUMAN [view interactions] High throughput no yes
TMM70_HUMAN [view interactions] High throughput no yes
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
DNJA3_HUMAN [view entry] [view interactions] High throughput yes yes
TIM14_HUMAN [view entry] [view interactions] High throughput yes yes
CISY_HUMAN [view entry] [view interactions] High throughput yes yes
ODPA_HUMAN [view entry] [view interactions] High throughput yes yes
TRAP1_HUMAN [view entry] [view interactions] High throughput yes yes
DPP4_HUMAN [view interactions] High throughput no no
QCR9_HUMAN [view interactions] Computational no no
NDUA9_HUMAN [view entry] [view interactions] Computational yes yes
QCR6_HUMAN [view interactions] Computational no yes
NDUS3_HUMAN [view entry] [view interactions] Computational yes yes
NDUB7_HUMAN [view entry] [view interactions] Computational yes yes
C560_HUMAN [view interactions] Computational no no
AT5G3_HUMAN [view interactions] Computational no no
NDUAC_HUMAN [view entry] [view interactions] Computational yes yes
NDUV2_HUMAN [view entry] [view interactions] Computational yes yes
AT5L2_HUMAN [view interactions] Computational no no
ATP5E_HUMAN [view interactions] Computational no no
SDHB_HUMAN [view interactions] Computational no yes
NDUB4_HUMAN [view entry] [view interactions] Computational yes yes
NDUC2_HUMAN [view interactions] Computational no yes
ATPD_HUMAN [view interactions] Computational no yes
NDUS4_HUMAN [view interactions] Computational no yes
QCR7_HUMAN [view entry] [view interactions] Computational yes yes
COA5_HUMAN [view interactions] Computational no yes
ATPO_HUMAN [view interactions] Computational no yes
NDUBB_HUMAN [view interactions] Computational no yes
MPC1_HUMAN [view interactions] Computational no yes
NDUCR_HUMAN [view interactions] Computational no yes
NDUB2_HUMAN [view interactions] Computational no yes
NDUB9_HUMAN [view entry] [view interactions] Computational yes yes
CYC_HUMAN [view entry] [view interactions] Computational yes yes
ACPM_HUMAN [view interactions] Computational no yes
NDUS7_HUMAN [view entry] [view interactions] Computational yes no
NDUS5_HUMAN [view interactions] Computational no yes
CX6A2_HUMAN [view interactions] Computational no no
MAVS_HUMAN [view interactions] Computational no yes
NDUB5_HUMAN [view interactions] Computational no yes
NDUAD_HUMAN [view entry] [view interactions] Computational yes yes
ATP5J_HUMAN [view interactions] Computational no yes
CY1_HUMAN [view entry] [view interactions] Computational yes yes
AT5F1_HUMAN [view interactions] Computational no yes
NDUV1_HUMAN [view entry] [view interactions] Computational yes yes
QCR1_HUMAN [view entry] [view interactions] Computational yes yes
NDUA7_HUMAN [view entry] [view interactions] Computational yes yes
NDUA5_HUMAN [view entry] [view interactions] Computational yes yes
UCRI_HUMAN [view entry] [view interactions] Computational yes yes
MPCP_HUMAN [view entry] [view interactions] Computational yes no
NDUB6_HUMAN [view entry] [view interactions] Computational yes yes
NDUBA_HUMAN [view entry] [view interactions] Computational yes yes
ATPK_HUMAN [view interactions] Computational no yes
ATP5H_HUMAN [view interactions] Computational no yes
ATPG_HUMAN [view interactions] Computational no yes
QCR6L_HUMAN [view interactions] Computational no yes
ATP5I_HUMAN [view interactions] Computational no yes
RM27_HUMAN [view interactions] Computational no yes
NDUS8_HUMAN [view interactions] Computational no yes
CX6B2_HUMAN [view interactions] Computational no no
COX42_HUMAN [view interactions] Computational no no
NDUA6_HUMAN [view interactions] Computational no no
NDUA2_HUMAN [view entry] [view interactions] Computational yes yes
QCR8_HUMAN [view interactions] Computational no yes
COA6_HUMAN [view interactions] Computational no yes
NDUA8_HUMAN [view entry] [view interactions] Computational yes yes
MPPB_HUMAN [view interactions] Computational no yes
NDUB8_HUMAN [view entry] [view interactions] Computational yes yes
AT5G1_HUMAN [view interactions] Computational no no
CYB_HUMAN [view interactions] Computational no yes
QCR10_HUMAN [view interactions] Computational no no
NDUS2_HUMAN [view entry] [view interactions] Computational yes yes
ATP5L_HUMAN [view interactions] Computational no yes