COX5B_HUMAN
Evidence for PS localization
Functions
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in COX5B_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 24.0741 | 4 | yes |
| GO:0046872 | metal ion binding | 24.0741 | 5 | yes |
| GO:0019900 | kinase binding | 24.0741 | 4 | no |
| GO:0019901 | protein kinase binding | 22.2222 | 5 | no |
| GO:0003723 | RNA binding | 22.2222 | 4 | no |
| GO:0043168 | anion binding | 22.2222 | 4 | no |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 20.3704 | 4 | yes |
| GO:0022853 | active monoatomic ion transmembrane transporter activity | 20.3704 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 20.3704 | 4 | yes |
| GO:0000166 | nucleotide binding | 20.3704 | 4 | no |
| GO:0015078 | proton transmembrane transporter activity | 18.5185 | 5 | yes |
| GO:0015399 | primary active transmembrane transporter activity | 18.5185 | 4 | yes |
| GO:0015453 | oxidoreduction-driven active transmembrane transporter activity | 16.6667 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in COX5B_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 48.1481 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 46.2963 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 44.4444 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 44.4444 | 4 | no |
| GO:0006996 | organelle organization | 38.8889 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 38.8889 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 37.0370 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 37.0370 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 37.0370 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 37.0370 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 37.0370 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 35.1852 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 35.1852 | 5 | no |
| GO:0010468 | regulation of gene expression | 35.1852 | 6 | no |
| GO:0010646 | regulation of cell communication | 35.1852 | 4 | no |
| GO:0022607 | cellular component assembly | 33.3333 | 4 | no |
| GO:0009966 | regulation of signal transduction | 33.3333 | 4 | no |
| GO:0008104 | protein localization | 31.4815 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 31.4815 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 31.4815 | 5 | no |
| GO:0071702 | organic substance transport | 29.6296 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 29.6296 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 29.6296 | 5 | no |
| GO:0031399 | regulation of protein modification process | 27.7778 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 27.7778 | 6 | no |
| GO:0009890 | negative regulation of biosynthetic process | 27.7778 | 5 | no |
| GO:0071705 | nitrogen compound transport | 25.9259 | 4 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 25.9259 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 25.9259 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 25.9259 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 25.9259 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.9259 | 4 | no |
| GO:0051049 | regulation of transport | 25.9259 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 25.9259 | 4 | no |
| GO:0043933 | protein-containing complex organization | 24.0741 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 24.0741 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 24.0741 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 24.0741 | 5 | no |
| GO:0023056 | positive regulation of signaling | 24.0741 | 4 | no |
| GO:0022900 | electron transport chain | 22.2222 | 4 | yes |
| GO:0022904 | respiratory electron transport chain | 22.2222 | 5 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 22.2222 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 22.2222 | 6 | no |
| GO:0080134 | regulation of response to stress | 22.2222 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 22.2222 | 5 | no |
| GO:0071310 | cellular response to organic substance | 22.2222 | 4 | no |
| GO:0009060 | aerobic respiration | 20.3704 | 6 | yes |
| GO:0015980 | energy derivation by oxidation of organic compounds | 20.3704 | 4 | yes |
| GO:0019646 | aerobic electron transport chain | 20.3704 | 6 | yes |
| GO:0045333 | cellular respiration | 20.3704 | 5 | yes |
| GO:0009894 | regulation of catabolic process | 20.3704 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 20.3704 | 6 | no |
| GO:0036211 | protein modification process | 20.3704 | 4 | no |
| GO:0043412 | macromolecule modification | 20.3704 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 20.3704 | 5 | no |
| GO:0019752 | carboxylic acid metabolic process | 20.3704 | 5 | no |
| GO:0043436 | oxoacid metabolic process | 20.3704 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 20.3704 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 20.3704 | 7 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 20.3704 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 20.3704 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 20.3704 | 4 | no |
| GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen | 14.8148 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ITM2B_HUMAN | [view interactions] | Low throughput | no | yes |
| COX2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| COX41_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ANDR_HUMAN | [view interactions] | Low throughput | no | no |
| COX7C_HUMAN | [view interactions] | Low throughput | no | yes |
| CX6B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CX6A1_HUMAN | [view interactions] | Low throughput | no | yes |
| COX5A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| COX1_HUMAN | [view interactions] | Low throughput | no | yes |
| CX7A2_HUMAN | [view interactions] | Low throughput | no | no |
| COX3_HUMAN | [view interactions] | Low throughput | no | yes |
| COX7B_HUMAN | [view interactions] | Low throughput | no | yes |
| COX6C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| COX8A_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| OPA3_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIM43_HUMAN | [view interactions] | High throughput | no | no |
| AT2B4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FANCM_HUMAN | [view interactions] | High throughput | no | no |
| QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SP7_HUMAN | [view interactions] | High throughput | no | no |
| KLF16_HUMAN | [view interactions] | High throughput | no | yes |
| EPB41_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTBP3_HUMAN | [view interactions] | High throughput | no | no |
| TX101_HUMAN | [view interactions] | High throughput | no | no |
| CNDD3_HUMAN | [view interactions] | High throughput | no | no |
| BHE40_HUMAN | [view interactions] | High throughput | no | yes |
| K1C15_HUMAN | [view interactions] | High throughput | no | no |
| CDR2_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF1_HUMAN | [view interactions] | High throughput | no | no |
| K1H1_HUMAN | [view interactions] | High throughput | no | no |
| PNMA1_HUMAN | [view interactions] | High throughput | no | yes |
| TFP11_HUMAN | [view interactions] | High throughput | no | no |
| PRDM6_HUMAN | [view interactions] | High throughput | no | no |
| CDR2L_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI27_HUMAN | [view interactions] | High throughput | no | yes |
| KAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1C27_HUMAN | [view interactions] | High throughput | no | no |
| ARI5A_HUMAN | [view interactions] | High throughput | no | yes |
| NUDT5_HUMAN | [view interactions] | High throughput | no | no |
| BORG1_HUMAN | [view interactions] | High throughput | no | yes |
| KT33B_HUMAN | [view interactions] | High throughput | no | no |
| MS18B_HUMAN | [view interactions] | High throughput | no | no |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHF2_HUMAN | [view interactions] | High throughput | no | yes |
| RBM48_HUMAN | [view interactions] | High throughput | no | yes |
| TEX12_HUMAN | [view interactions] | High throughput | no | no |
| SLAI1_HUMAN | [view interactions] | High throughput | no | no |
| F228A_HUMAN | [view interactions] | High throughput | no | no |
| MCCD1_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX14_HUMAN | [view interactions] | High throughput | no | yes |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDK1_HUMAN | [view interactions] | High throughput | no | yes |
| SCO1_HUMAN | [view interactions] | High throughput | no | yes |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| HTRA2_HUMAN | [view interactions] | High throughput | no | yes |
| IMP1L_HUMAN | [view interactions] | High throughput | no | yes |
| LACTB_HUMAN | [view interactions] | High throughput | no | yes |
| OMA1_HUMAN | [view interactions] | High throughput | no | no |
| PARL_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
| LSM4_HUMAN | [view interactions] | High throughput | no | yes |
| DOK3_HUMAN | [view interactions] | High throughput | no | no |
| VPS28_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAXO4_HUMAN | [view interactions] | High throughput | no | no |
| PRR22_HUMAN | [view interactions] | High throughput | no | no |
| NELFD_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STB5L_HUMAN | [view interactions] | High throughput | no | no |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| EMC5_HUMAN | [view interactions] | High throughput | no | yes |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| DPS1_HUMAN | [view interactions] | High throughput | no | yes |
| 2ABD_HUMAN | [view interactions] | High throughput | no | yes |
| ATPF2_HUMAN | [view interactions] | High throughput | no | yes |
| DPP9_HUMAN | [view interactions] | High throughput | no | yes |
| TOP3A_HUMAN | [view interactions] | High throughput | no | yes |
| DLP1_HUMAN | [view interactions] | High throughput | no | no |
| COX7R_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HEM1_HUMAN | [view interactions] | High throughput | no | yes |
| CF062_HUMAN | [view interactions] | High throughput | no | yes |
| MMSA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDUF5_HUMAN | [view interactions] | High throughput | no | yes |
| SPT20_HUMAN | [view interactions] | High throughput | no | yes |
| EPDR1_HUMAN | [view interactions] | High throughput | no | yes |
| COXM2_HUMAN | [view interactions] | High throughput | no | yes |
| COA3_HUMAN | [view interactions] | High throughput | no | yes |
| AUHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPOG1_HUMAN | [view interactions] | High throughput | no | yes |
| CX7A1_HUMAN | [view interactions] | High throughput | no | no |
| ODB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CX7B2_HUMAN | [view interactions] | High throughput | no | no |
| FFAR1_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AURKA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYCN_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYTN_HUMAN | [view interactions] | High throughput | no | no |
| UBP11_HUMAN | [view interactions] | High throughput | no | yes |
| CL16A_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHCH2_HUMAN | [view interactions] | High throughput | no | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD7_HUMAN | [view interactions] | High throughput | no | yes |
| TOM40_HUMAN | [view interactions] | High throughput | no | yes |
| VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDFY1_HUMAN | [view interactions] | High throughput | no | yes |
| PPIL3_HUMAN | [view interactions] | High throughput | no | yes |
| RLA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPB_HUMAN | [view interactions] | High throughput | no | yes |
| PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPA_HUMAN | [view interactions] | High throughput | no | yes |
| ECHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| MRM1_HUMAN | [view interactions] | High throughput | no | no |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | no |
| CC90B_HUMAN | [view interactions] | High throughput | no | yes |
| MET17_HUMAN | [view interactions] | High throughput | no | yes |
| MIC26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RMND1_HUMAN | [view interactions] | High throughput | no | yes |
| S2512_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SURF1_HUMAN | [view interactions] | High throughput | no | yes |
| TMM70_HUMAN | [view interactions] | High throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIM14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRIM1_HUMAN | [view interactions] | High throughput | no | no |
| TRI23_HUMAN | [view interactions] | High throughput | no | yes |
| TASO2_HUMAN | [view interactions] | High throughput | no | yes |
| IHO1_HUMAN | [view interactions] | High throughput | no | no |
| SAV1_HUMAN | [view interactions] | High throughput | no | yes |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| NDUAB_HUMAN | [view interactions] | High throughput | no | no |
| TIDC1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMED2_HUMAN | [view interactions] | High throughput | no | yes |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YIPF5_HUMAN | [view interactions] | High throughput | no | yes |
| SHLD3_HUMAN | [view interactions] | High throughput | no | yes |
| NMES1_HUMAN | [view interactions] | High throughput | no | no |