COX5B_HUMAN
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in COX5B_HUMAN |
---|---|---|---|---|
GO:0015399 | primary active transmembrane transporter activity | 42.4658 | 4 | yes |
GO:0015453 | oxidoreduction-driven active transmembrane transporter activity | 41.0959 | 5 | yes |
GO:0003954 | NADH dehydrogenase activity | 30.1370 | 4 | no |
GO:0003955 | NAD(P)H dehydrogenase (quinone) activity | 28.7671 | 5 | no |
GO:0008137 | NADH dehydrogenase (ubiquinone) activity | 28.7671 | 4 | no |
GO:0016655 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | 28.7671 | 4 | no |
GO:0050136 | NADH dehydrogenase (quinone) activity | 28.7671 | 5 | no |
GO:0046872 | metal ion binding | 26.0274 | 4 | yes |
GO:0008324 | cation transmembrane transporter activity | 15.0685 | 4 | yes |
GO:0022853 | active ion transmembrane transporter activity | 15.0685 | 4 | yes |
GO:0022890 | inorganic cation transmembrane transporter activity | 15.0685 | 4 | yes |
GO:0015078 | proton transmembrane transporter activity | 13.6986 | 5 | yes |
GO:0004129 | cytochrome-c oxidase activity | 8.2192 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in COX5B_HUMAN |
---|---|---|---|---|
GO:0009060 | aerobic respiration | 43.8356 | 6 | yes |
GO:0015980 | energy derivation by oxidation of organic compounds | 43.8356 | 4 | yes |
GO:0022900 | electron transport chain | 43.8356 | 4 | yes |
GO:0022904 | respiratory electron transport chain | 43.8356 | 5 | yes |
GO:0045333 | cellular respiration | 43.8356 | 5 | yes |
GO:0022607 | cellular component assembly | 42.4658 | 4 | no |
GO:0019646 | aerobic electron transport chain | 41.0959 | 6 | yes |
GO:0043933 | protein-containing complex organization | 36.9863 | 4 | no |
GO:0065003 | protein-containing complex assembly | 36.9863 | 5 | no |
GO:0080090 | regulation of primary metabolic process | 32.8767 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 31.5068 | 4 | no |
GO:0048522 | positive regulation of cellular process | 31.5068 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 31.5068 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 30.1370 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 28.7671 | 4 | no |
GO:0048523 | negative regulation of cellular process | 27.3973 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 27.3973 | 5 | no |
GO:0006120 | mitochondrial electron transport, NADH to ubiquinone | 26.0274 | 7 | no |
GO:0006996 | organelle organization | 24.6575 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 24.6575 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 24.6575 | 5 | no |
GO:0033108 | mitochondrial respiratory chain complex assembly | 24.6575 | 6 | no |
GO:0009892 | negative regulation of metabolic process | 23.2877 | 4 | no |
GO:0010646 | regulation of cell communication | 23.2877 | 4 | no |
GO:0010257 | NADH dehydrogenase complex assembly | 23.2877 | 6 | no |
GO:0032981 | mitochondrial respiratory chain complex I assembly | 23.2877 | 7 | no |
GO:0009889 | regulation of biosynthetic process | 21.9178 | 4 | no |
GO:0009966 | regulation of signal transduction | 21.9178 | 4 | no |
GO:0010468 | regulation of gene expression | 21.9178 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 21.9178 | 5 | no |
GO:0008104 | protein localization | 20.5479 | 4 | no |
GO:0071702 | organic substance transport | 20.5479 | 4 | no |
GO:0010941 | regulation of cell death | 20.5479 | 4 | no |
GO:0051247 | positive regulation of protein metabolic process | 20.5479 | 6 | no |
GO:1902531 | regulation of intracellular signal transduction | 20.5479 | 5 | no |
GO:0051049 | regulation of transport | 20.5479 | 4 | no |
GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen | 9.5890 | 7 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
COX8A_HUMAN | [view interactions] | Low throughput | no | yes |
COX3_HUMAN | [view interactions] | Low throughput | no | yes |
COX6C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
COX7B_HUMAN | [view interactions] | Low throughput | no | yes |
CX7A2_HUMAN | [view interactions] | Low throughput | no | no |
NDUA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
COX2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
COX41_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ANDR_HUMAN | [view interactions] | Low throughput | no | no |
COX7C_HUMAN | [view interactions] | Low throughput | no | yes |
CX6B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CX6A1_HUMAN | [view interactions] | Low throughput | no | yes |
COX5A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
COX1_HUMAN | [view interactions] | Low throughput | no | yes |
TRIM1_HUMAN | [view interactions] | High throughput | no | no |
TRI23_HUMAN | [view interactions] | High throughput | no | yes |
TASO2_HUMAN | [view interactions] | High throughput | no | yes |
IHO1_HUMAN | [view interactions] | High throughput | no | no |
SAV1_HUMAN | [view interactions] | High throughput | no | yes |
OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
NDUAB_HUMAN | [view interactions] | High throughput | no | no |
TIDC1_HUMAN | [view interactions] | High throughput | no | yes |
RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TMED2_HUMAN | [view interactions] | High throughput | no | yes |
VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
YIPF5_HUMAN | [view interactions] | High throughput | no | yes |
SHLD3_HUMAN | [view interactions] | High throughput | no | yes |
NMES1_HUMAN | [view interactions] | High throughput | no | no |
OPA3_HUMAN | [view interactions] | High throughput | no | yes |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AT2B4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FANCM_HUMAN | [view interactions] | High throughput | no | no |
QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SP7_HUMAN | [view interactions] | High throughput | no | no |
KLF16_HUMAN | [view interactions] | High throughput | no | yes |
EPB41_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PTBP3_HUMAN | [view interactions] | High throughput | no | no |
TX101_HUMAN | [view interactions] | High throughput | no | no |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
CNDD3_HUMAN | [view interactions] | High throughput | no | no |
BHE40_HUMAN | [view interactions] | High throughput | no | yes |
K1C15_HUMAN | [view interactions] | High throughput | no | no |
CDR2_HUMAN | [view interactions] | High throughput | no | yes |
TRAF1_HUMAN | [view interactions] | High throughput | no | no |
K1H1_HUMAN | [view interactions] | High throughput | no | no |
PNMA1_HUMAN | [view interactions] | High throughput | no | yes |
TFP11_HUMAN | [view interactions] | High throughput | no | no |
PRDM6_HUMAN | [view interactions] | High throughput | no | no |
CDR2L_HUMAN | [view interactions] | High throughput | no | yes |
GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRI27_HUMAN | [view interactions] | High throughput | no | yes |
KAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
K1C27_HUMAN | [view interactions] | High throughput | no | no |
ARI5A_HUMAN | [view interactions] | High throughput | no | yes |
NUDT5_HUMAN | [view interactions] | High throughput | no | no |
BORG1_HUMAN | [view interactions] | High throughput | no | yes |
KT33B_HUMAN | [view interactions] | High throughput | no | no |
MS18B_HUMAN | [view interactions] | High throughput | no | no |
FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PKHF2_HUMAN | [view interactions] | High throughput | no | yes |
RBM48_HUMAN | [view interactions] | High throughput | no | yes |
TEX12_HUMAN | [view interactions] | High throughput | no | no |
SLAI1_HUMAN | [view interactions] | High throughput | no | no |
F228A_HUMAN | [view interactions] | High throughput | no | no |
MCCD1_HUMAN | [view interactions] | High throughput | no | no |
ESR1_HUMAN | [view interactions] | High throughput | no | no |
CLPP_HUMAN | [view interactions] | High throughput | no | yes |
AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COX14_HUMAN | [view interactions] | High throughput | no | yes |
MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PDK1_HUMAN | [view interactions] | High throughput | no | yes |
SCO1_HUMAN | [view interactions] | High throughput | no | yes |
IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
HTRA2_HUMAN | [view interactions] | High throughput | no | yes |
IMP1L_HUMAN | [view interactions] | High throughput | no | yes |
LACTB_HUMAN | [view interactions] | High throughput | no | yes |
OMA1_HUMAN | [view interactions] | High throughput | no | no |
PARL_HUMAN | [view interactions] | High throughput | no | yes |
FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
LSM4_HUMAN | [view interactions] | High throughput | no | yes |
DOK3_HUMAN | [view interactions] | High throughput | no | no |
VPS28_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PPR32_HUMAN | [view interactions] | High throughput | no | no |
PRR22_HUMAN | [view interactions] | High throughput | no | no |
NELFD_HUMAN | [view interactions] | High throughput | no | yes |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STB5L_HUMAN | [view interactions] | High throughput | no | no |
GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MOV10_HUMAN | [view interactions] | High throughput | no | no |
NXF1_HUMAN | [view interactions] | High throughput | no | yes |
CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
EMC1_HUMAN | [view interactions] | High throughput | no | yes |
EMC5_HUMAN | [view interactions] | High throughput | no | yes |
KI20A_HUMAN | [view interactions] | High throughput | no | yes |
PRC1_HUMAN | [view interactions] | High throughput | no | yes |
DPS1_HUMAN | [view interactions] | High throughput | no | yes |
2ABD_HUMAN | [view interactions] | High throughput | no | yes |
ATPF2_HUMAN | [view interactions] | High throughput | no | yes |
DPP9_HUMAN | [view interactions] | High throughput | no | yes |
TOP3A_HUMAN | [view interactions] | High throughput | no | yes |
DLP1_HUMAN | [view interactions] | High throughput | no | no |
COX7R_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HEM1_HUMAN | [view interactions] | High throughput | no | yes |
CF062_HUMAN | [view interactions] | High throughput | no | yes |
MMSA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NDUF5_HUMAN | [view interactions] | High throughput | no | yes |
SPT20_HUMAN | [view interactions] | High throughput | no | yes |
EPDR1_HUMAN | [view interactions] | High throughput | no | yes |
COXM2_HUMAN | [view interactions] | High throughput | no | yes |
COA3_HUMAN | [view interactions] | High throughput | no | yes |
AUHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DPOG1_HUMAN | [view interactions] | High throughput | no | yes |
CX7A1_HUMAN | [view interactions] | High throughput | no | no |
ODB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CX7B2_HUMAN | [view interactions] | High throughput | no | no |
FFAR1_HUMAN | [view interactions] | High throughput | no | no |
RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ODP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CHCH2_HUMAN | [view interactions] | High throughput | no | yes |
AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSMD7_HUMAN | [view interactions] | High throughput | no | yes |
TOM40_HUMAN | [view interactions] | High throughput | no | yes |
VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
WDFY1_HUMAN | [view interactions] | High throughput | no | yes |
PPIL3_HUMAN | [view interactions] | High throughput | no | yes |
RLA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATPB_HUMAN | [view interactions] | High throughput | no | yes |
PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATPA_HUMAN | [view interactions] | High throughput | no | yes |
ECHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRI14_HUMAN | [view interactions] | High throughput | no | yes |
MRM1_HUMAN | [view interactions] | High throughput | no | no |
GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
GAL3B_HUMAN | [view interactions] | High throughput | no | yes |
CC90B_HUMAN | [view interactions] | High throughput | no | yes |
MET17_HUMAN | [view interactions] | High throughput | no | yes |
MIC26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RMND1_HUMAN | [view interactions] | High throughput | no | yes |
CMC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SURF1_HUMAN | [view interactions] | High throughput | no | yes |
TMM70_HUMAN | [view interactions] | High throughput | no | yes |
GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DNJA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TIM14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DPP4_HUMAN | [view interactions] | High throughput | no | no |
QCR9_HUMAN | [view interactions] | Computational | no | no |
NDUA9_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
QCR6_HUMAN | [view interactions] | Computational | no | yes |
NDUS3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NDUB7_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
C560_HUMAN | [view interactions] | Computational | no | no |
AT5G3_HUMAN | [view interactions] | Computational | no | no |
NDUAC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NDUV2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AT5L2_HUMAN | [view interactions] | Computational | no | no |
ATP5E_HUMAN | [view interactions] | Computational | no | no |
SDHB_HUMAN | [view interactions] | Computational | no | yes |
NDUB4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NDUC2_HUMAN | [view interactions] | Computational | no | yes |
ATPD_HUMAN | [view interactions] | Computational | no | yes |
NDUS4_HUMAN | [view interactions] | Computational | no | yes |
QCR7_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
COA5_HUMAN | [view interactions] | Computational | no | yes |
ATPO_HUMAN | [view interactions] | Computational | no | yes |
NDUBB_HUMAN | [view interactions] | Computational | no | yes |
MPC1_HUMAN | [view interactions] | Computational | no | yes |
NDUCR_HUMAN | [view interactions] | Computational | no | yes |
NDUB2_HUMAN | [view interactions] | Computational | no | yes |
NDUB9_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CYC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ACPM_HUMAN | [view interactions] | Computational | no | yes |
NDUS7_HUMAN | [view entry] [view interactions] | Computational | yes | no |
NDUS5_HUMAN | [view interactions] | Computational | no | yes |
CX6A2_HUMAN | [view interactions] | Computational | no | no |
MAVS_HUMAN | [view interactions] | Computational | no | yes |
NDUB5_HUMAN | [view interactions] | Computational | no | yes |
NDUAD_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ATP5J_HUMAN | [view interactions] | Computational | no | yes |
CY1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AT5F1_HUMAN | [view interactions] | Computational | no | yes |
NDUV1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
QCR1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NDUA7_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NDUA5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
UCRI_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MPCP_HUMAN | [view entry] [view interactions] | Computational | yes | no |
NDUB6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NDUBA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ATPK_HUMAN | [view interactions] | Computational | no | yes |
ATP5H_HUMAN | [view interactions] | Computational | no | yes |
ATPG_HUMAN | [view interactions] | Computational | no | yes |
QCR6L_HUMAN | [view interactions] | Computational | no | yes |
ATP5I_HUMAN | [view interactions] | Computational | no | yes |
RM27_HUMAN | [view interactions] | Computational | no | yes |
NDUS8_HUMAN | [view interactions] | Computational | no | yes |
CX6B2_HUMAN | [view interactions] | Computational | no | no |
COX42_HUMAN | [view interactions] | Computational | no | no |
NDUA6_HUMAN | [view interactions] | Computational | no | no |
NDUA2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
QCR8_HUMAN | [view interactions] | Computational | no | yes |
COA6_HUMAN | [view interactions] | Computational | no | yes |
NDUA8_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MPPB_HUMAN | [view interactions] | Computational | no | yes |
NDUB8_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AT5G1_HUMAN | [view interactions] | Computational | no | no |
CYB_HUMAN | [view interactions] | Computational | no | yes |
QCR10_HUMAN | [view interactions] | Computational | no | no |
NDUS2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ATP5L_HUMAN | [view interactions] | Computational | no | yes |